JP2004290977A - Production method for microcapsule and apparatus therefor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a production method for a microcapsule and an apparatus therefor capable of simply and quickly forming the microcapsule by making a continuous phase act additionally upon a dispersed phase which was made to act in two stages. <P>SOLUTION: In the production method for the microcapsule, the microcapsule 20 is produced by feeding a phase 18 to be used as a shell and an internally contained phase 19 to a continuous phase 17 running in a microchannel 12 in the crossing direction of the continuous phase 17, and by feeding the phase 18 to the phase 19 from the upstream so as to form a thin layer. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a method and apparatus for producing microscopic microcapsules in water, oil, and a chemically inert liquid.

2. Description of the Related Art Conventionally, an apparatus for manufacturing microscopic microcapsules has been used in a manufacturing process of chemicals, and several manufacturing methods have been proposed. For example, there are various methods such as a method in which the second solution is dropped into the first solution, a method in which the first solution is dropped from the inside of the double tube toward the air, and a method in which the second solution is dropped from the outside (for example, Japanese Patent Application Publication No. JP-A-8-508933). As a method of dispersing droplets in the air, there is a method of ejecting droplets by piezoelectricity used in an ink jet printer or the like.
None

  On the other hand, as a technique for producing monodispersed microdroplets as laboratory equipment, there is JP-A-2000-84384. However, this method has a problem that the speed at which the microdroplets are formed is slow, and the microdroplets cannot be wrapped in the surfactant or the microcapsule. Further, only a microdroplet having a diameter of three times or more the microchannel width could be formed.

  In view of the above circumstances, the present invention provides a method for producing microcapsules and a device for producing microcapsules, which can easily and quickly produce microcapsules by further applying a continuous phase to the dispersed phase that has been made to act in two stages. The purpose is to provide.

The present invention, in order to achieve the above object,
[1] In the method for producing a microcapsule, a phase serving as a shell and a phase contained therein are supplied in a direction intersecting the flow of the continuous phase to the continuous phase flowing in the microchannel, thereby forming the shell. The phase is supplied so as to form a thin layer from the upstream side with respect to the phase contained therein to obtain microcapsules.

  [2] In the method for manufacturing microcapsules, the first and second continuous phases flowing in the first and second microchannels formed on both sides are separated from the first and second continuous phases by the first and second continuous phases. The second and third continuous phases are fed in a direction intersecting the flow of the two continuous phases to form microdroplets encapsulated therein, and then the shells for the third and fourth continuous phases flowing in the third and fourth microchannels Is supplied to a junction point with the third and fourth continuous phases in a direction crossing the flow, and microdroplets serving as shells are formed to obtain microcapsules.

  [3] In the method for producing microcapsules, the first continuous phase and the dispersed phase merge at the first junction to generate microdroplets, and the first continuous phase including the microdroplets is further converted to the second continuous phase. A microcapsule containing the microdroplets in the first continuous phase by merging with the continuous phase at a second junction.

  [4] In the microcapsule manufacturing apparatus, means for generating a continuous phase flowing through the microchannel, and means for supplying a shell phase and a phase contained therein in a direction intersecting the flow of the continuous phase. Means for supplying the phase to be the shell so as to form a thin layer from the upstream side with respect to the phase contained therein.

  [5] In the microcapsule manufacturing apparatus, the first and second continuous phases flowing in the first and second microchannels formed on both sides are separated from the first and second continuous phases by the first and second continuous phases. The second and third continuous phases flow in a direction intersecting to form microdroplets encapsulated therein, and then flow through the third and fourth microchannels to form a shell. A means for supplying micro-capsules by supplying a phase to the junction with the third and fourth continuous phases in a direction crossing the flow, and forming a shell coating. I do.

  [6] In the microcapsule manufacturing apparatus according to the above [4] or [5], as a means for supplying a plurality of shell phases and a phase contained therein, the substrate, the driven plate, the substrate and the driven An elastic member disposed between the plates and an actuator for driving the driven plate are provided, and the plurality of shell phases and the phases contained therein are simultaneously supplied.

  [7] In the microcapsule manufacturing apparatus according to the above [4] or [5], the microcapsules are formed on the respective inner wall surfaces of the microchannel through which the continuous phase flows and the dispersed phase supply channel near where the continuous phase and the dispersed phase merge. It is characterized in that a film is formed so as to easily generate droplets.

  According to the present invention, a continuous phase can further act on the dispersed phase that has acted in two stages, and microcapsules can be easily and quickly generated.

  Hereinafter, embodiments of the present invention will be described in detail.

  FIG. 1 is a plan view of an apparatus for producing microdroplets according to a first embodiment of the present invention, and FIG. 2 is an explanatory diagram of a method for producing the microdroplets. Here, FIG. 2A is an explanatory diagram of a method for manufacturing the microdroplet (No. 1), and FIG. 2B is an explanatory diagram of a method for manufacturing the microdroplet (No. 2). b-1) is a partial sectional view thereof, and FIG. 2B-2 is a sectional view taken along line AA of FIG. 2B-1.

  In these figures, 1 is a main body of a device for producing microdroplets, 2 is a microchannel formed in the main body 1 and through which a continuous phase flows, and 3 is a dispersed phase supply formed in a direction crossing the microchannel 2. The channel 4 is a dispersed phase supply port, 5 is a continuous phase (eg, oil), 6 is a dispersed phase (eg, water), 7 is microdroplets, and 8 is a hydrophobic film.

  Therefore, the dispersed phase 6 is supplied to the continuous phase 5 flowing in the microchannel 2 in a direction crossing the flow of the continuous phase 5 as shown in FIG. By entering, the microdroplets 7 smaller in diameter than the width of the dispersed phase supply channel 3 can be manufactured.

  For example, when the pressure of the dispersed phase (water) 6 is fixed at 2.45 kPa, and when the pressure of the continuous phase (oil: 70% oleic acid) 5 is 4.85 kPa, the size of the microchannels 2 and 3 is changed to the width. When the height is 100 μm and the width is 100 μm, the diameter of the fine droplet is about 25 μm. When the pressure of the continuous phase is 5.03 kPa, the diameter of the fine droplet is about 5 μm.

  As shown in FIGS. 2 (b-1) and 2 (b-2), a microchannel through which a continuous phase 5 near a confluence of a continuous phase (eg, oil) 5 and a dispersed phase (eg, water) 6 flows. It is preferable to form a hydrophobic film 8 on the inner wall surfaces of the dispersion phase supply channel 3 and the dispersed phase supply channel 3 so that the microdroplets 7 are easily generated (the microdroplets are easily repelled).

  In the above embodiment, since the continuous phase 5 is oil and the dispersed phase 6 is water, the hydrophobic film 8 is preferable. However, when the continuous phase is water and the dispersed phase is oil, It is preferable to provide a hydrophilic film.

  FIG. 3 is a plan view of an apparatus for manufacturing microcapsules according to a second embodiment of the present invention, and FIG. 4 is an explanatory diagram of a method for manufacturing the microcapsules.

  In these figures, 11 is a main body of the microcapsule manufacturing apparatus, 12 is a microchannel formed in the main body 11 through which a continuous phase flows, and 13 is a shell formed in a direction crossing the microchannel 12. A phase supply channel, 14 is formed in a direction crossing the microchannel 12, and is a phase supply channel contained therein, 15 is a phase supply port serving as a shell, 16 is a phase supply port contained, and 17 is a continuous phase ( For example, water), 18 is a shell phase, 19 is a phase contained therein, and 20 is a microcapsule.

  Therefore, a phase 18 serving as a shell and a phase 19 contained therein are supplied to the continuous phase 17 flowing in the microchannel 12 in a direction crossing the flow of the continuous phase 17 as shown in FIG. The phase 18 is supplied in a thin layer from the upstream side to the phase 19 contained therein.

  FIG. 5 is a plan view of an apparatus for producing microdroplets according to a third embodiment of the present invention, and FIG. 6 is an explanatory view of a method for producing the microdroplets.

  In these figures, 21 is the main body of the apparatus for producing microdroplets, 22 is the first microchannel, 23 is the second microchannel, 24 is the first continuous phase, 25 is the second continuous phase, and 26 is A point where the first continuous phase 24 and the second continuous phase 25 meet, 27 is a dispersed phase supply channel, 28 is a dispersed phase, and 29 is a microdroplet.

  Therefore, at the confluence point 26 of the continuous phases 24 and 25 flowing in the microchannels 22 and 23, the dispersed phase 28 is sent out so as to intersect the flow of the continuous phases 24 and 25 as shown in FIG. Can be manufactured.

  FIG. 7 is a plan view of an apparatus for manufacturing a microcapsule according to a fourth embodiment of the present invention, and FIG. 8 is an explanatory view of a method for manufacturing the microcapsule.

  In these figures, 31 is the main body of the microcapsule manufacturing apparatus, 32 is the first microchannel formed in the main body 31 and the continuous phase flows, 33 is the second microchannel formed in the main body 31 and the continuous phase flows. Microchannel, 34 is a first continuous phase (eg, oil), 35 is a second continuous phase (eg, oil), 36 is a junction point of the first continuous phase 34 and the second continuous phase 35, 37 Is a phase supply channel contained therein, 38 is a phase contained therein (for example, water), 39 is a microdroplet (for example, water ball), 40 is formed in the main body 31, and a third phase in which a continuous phase flows Microchannels, 41, are formed in the body 31 and are fourth microchannels through which a continuous phase flows, 42 is a third continuous phase (eg, water), 43 is a fourth continuous phase (eg, water), and 44 is a fourth continuous phase. 3 continuous phases 42 and 4 Confluence point of the continuous phase, 45 is a shell phase, 46 minute droplets comprising a shell, 47 a microcapsule.

  Therefore, as shown in FIG. 8, the continuous phase 34, 35 flowing in the first and second microchannels 32, 33 is replaced with a phase 38 contained therein, as shown in FIG. The liquid is supplied in a direction intersecting with the flow of 35 to form microdroplets 39 included therein.

  Next, a continuous phase 42, 43 flowing through the third and fourth microchannels 40, 41 is combined with a combined phase 45, which is a shell composed of the first and second continuous phases 34, 35, to form a third continuous phase. The microcapsules 47 are produced by feeding in a direction crossing the flow at the junction point 44 of the phase 42 and the fourth continuous phase 43 to form a shell coating on the outside of the encapsulated microdroplets 39. be able to.

  In this embodiment, one microdroplet 39 is included in the microcapsule 47, but a plurality of microdroplets 39 may be included.

  Incidentally, the size of the first and second micro channels 32 and 33 and the dispersed phase supply channel 37 is 100 μm in width and 100 μm in height, and the third micro channel (the channel in which the microdroplets 39 are present) is 500 μm in width. FIG. 9 shows the particle diameter when the height (converted to pressure) of the continuous phase and the dispersed phase was changed with the height and width being 100 μm. It is apparent from this that the particle diameter can be controlled by changing the height (converted to pressure) of the continuous phase and the dispersed phase.

  FIG. 10 is an explanatory view of a mechanism for sending out a dispersed phase or a phase contained in a shell or inside of a device for producing microdroplets according to a fifth embodiment of the present invention. FIG. FIG. 10B shows a state before the phase is sent out, and FIG. 10B shows a state in which the piezo actuator expands and contracts and sends out the phase.

  In these figures, 51 is a substrate, 52 is a driven plate, 53 is a rubber, 54 is a piezo actuator disposed at both ends of the driven plate 52, 55a to 55d are a plurality of supply ports, and 56a to 56d are one. It is a plurality of paths formed in the dispersed phase. Back pressure is applied to the lower part of the dispersed phase.

  As shown in FIG. 10 (a), a plurality of paths 56a to 56d are formed, which can simultaneously send out the dispersed phase by the reduction of the piezoelectric actuator 54 as shown in FIG. 10 (b). it can.

  Note that various actuators may be used instead of the above-described piezo actuator.

  FIG. 11 is an explanatory view of a mechanism for sending out a dispersed phase or a shell or a phase contained in the inside of a device for producing microdroplets according to a sixth embodiment of the present invention. FIG. FIG. 11B shows a state before the bimorph actuator is bent and sends out a phase.

  In these figures, 61 is a bimorph actuator, 62 is a fixed plate, 63 is rubber, 64a to 64d are a plurality of supply ports, and 65a to 65d are a plurality of paths formed in one dispersed phase. Back pressure is applied to the lower part of the dispersed phase.

  In this way, as shown in FIG. 11A, a plurality of paths 65a to 65d are formed, and as shown in FIG. 11B, by driving the bimorph actuator 61 (curving upward), the paths 65a to 65d are simultaneously formed. The disperse phase can be sent out.

  FIG. 12 is an explanatory view of a mechanism for sending out a dispersed phase or a shell or a phase contained in the inside of a device for producing microdroplets according to a seventh embodiment of the present invention, and FIG. 12 (a) shows an electrostrictive polymer. FIG. 12B is a diagram illustrating a state in which the body is not driven and before the phase is sent out, and FIG. 12B illustrates a state in which the electrostrictive polymer is driven (expanded and contracted) to send out the phase.

  In these figures, 71 is a substrate, 72 is a driven plate, 73 is an electrostrictive polymer, 74a to 74d are a plurality of supply ports, and 75a to 75d are a plurality of paths formed in one dispersed phase. . Back pressure is applied to the lower part of the dispersed phase.

  As shown in FIG. 12A, a plurality of paths 75a to 75d are formed. As shown in FIG. 12B, by driving (reducing) the electrostrictive polymer 73, the dispersed phase is simultaneously formed. Can be sent out.

  FIG. 13 is a configuration diagram of the opening / closing mechanism of the dispersed phase supply port of the apparatus for manufacturing microdroplets according to the eighth embodiment of the present invention. FIG. 13 (a) shows that the piezo actuator is not driven (reduced state). FIG. 13B is a diagram illustrating a state in which the phase gate is opened, and FIG. 13B is a diagram illustrating a state in which the piezo actuator is driven (expanded and contracted) and the phase gate is closed.

  In these figures, 81 is a substrate, 82 is a rubber, 83 is a driven plate, 84 is a piezo actuator arranged on both sides, 85 is a fixed plate, and 86a to 86d are a plurality of gates.

  As shown in this figure, a plurality of gates 86a to 86d are formed, and by driving two piezo actuators 84 arranged on both sides, the gates of all the phases can be closed.

  Note that various actuators may be used instead of the above-described piezo actuator.

  FIG. 14 is a diagram showing the configuration of the opening / closing mechanism of the dispersed phase supply port of the apparatus for manufacturing microdroplets according to the ninth embodiment of the present invention. FIG. FIG. 14B is a diagram illustrating a state in which the phase gate is open, and FIG. 14B is a diagram illustrating a state in which the bimorph actuator is driven (curved downward) and the phase gate is closed.

  In these figures, 91 is a substrate, 92 is a rubber, 93 is a bimorph actuator, and 94a to 94d are a plurality of gates.

  As shown in these figures, a plurality of gates 94a to 94d are formed, and by driving the bimorph actuator 93, the plurality of gates 94a to 94d can be closed at the same time.

  FIG. 15 is a configuration diagram of the opening / closing mechanism of the dispersed phase supply port of the apparatus for manufacturing microdroplets according to the tenth embodiment of the present invention, and FIG. 15A shows that the electrostrictive polymer is not driven. FIG. 15B is a diagram illustrating a state in which the phase gate is open, and FIG. 15B is a diagram illustrating a state in which the electrostrictive polymer is driven (reduced) to close the phase gate.

  In these figures, 101 is a substrate, 102 is a driven plate, 103 is an electrostrictive polymer, and 104a to 104d are a plurality of gates.

  As shown in FIG. 15A, in a state in which the electrostrictive polymer 103 is not driven (extended), a plurality of gates 104a to 104d are opened, and as shown in FIG. By driving (reducing) the electrostrictive polymer 103, a plurality of gates 104a to 104d can be closed at the same time.

  FIG. 16 is a plan view of an emulsion manufacturing apparatus showing an eleventh embodiment of the present invention, and FIG. 16 (a) is a plan view showing a state before a dispersed phase is introduced into the emulsion manufacturing apparatus. FIG. 16B is a plan view showing a state in which the liquid is filled in the emulsion manufacturing apparatus. FIG. 16C is a view in which a large droplet is set in the emulsion manufacturing apparatus, and a minute liquid droplet ( FIG. 3 is a diagram illustrating a state in which an emulsion is being generated.

  In these figures, 111 is a substrate, 112 is an electrode formed on the substrate 111, 113 is a microchannel formed on the substrate 111 on which the electrode 112 is formed, 114 is a dispersed phase, and 115 is a microchannel 113. 3 shows an emulsion formed by passing through the emulsion.

  In this embodiment, the electrode 112 is formed so as to be orthogonal to the microchannel 113, and an emulsion 115 is generated by a moving electric field applied to the electrode 112, and the emulsion 115 is moved by static electricity applied to the electrode 112. The electric field guides the electrode in a direction perpendicular to the electrodes (here, downward).

  Also, by changing the moving speed of the moving electric field, it is possible to change the generation speed of the minute droplet.

  FIG. 17 is a plan view of an emulsion manufacturing apparatus showing a twelfth embodiment of the present invention, and FIG. 17 (a) is a plan view showing a state before a dispersed phase is introduced into the emulsion manufacturing apparatus. (B) is a diagram showing a state in which a dispersed phase is introduced into the emulsion manufacturing apparatus and an emulsion is being generated.

  In these figures, 121 is a substrate, 122 is an electrode formed on the substrate 121, 123 is a microchannel formed on the substrate 121 on which the electrode is formed, 124 is a dispersed phase, and 125 is a microchannel 123. 3 shows an emulsion produced by passing through.

  In this embodiment, the electrode 122 is formed in the vertical direction on the exit side of the microchannel 123, and the generated emulsion 125 is guided in the horizontal direction by the static electricity applied to the electrode 122.

  FIG. 18 is an explanatory diagram of an emulsion generating apparatus showing a thirteenth embodiment of the present invention, and FIG. 18 (a) is a schematic diagram showing an entire configuration of the monodisperse emulsion generating apparatus, and FIG. Is a left side view, FIG. 18 (a-2) is a schematic plan view thereof, and FIG. 18 (a-3) is a right side view thereof. FIG. 18B is an explanatory diagram of the first junction, and FIG. 18C is an explanatory diagram of the second junction.

  In these figures, 131 is the main body of the apparatus for producing microdroplets, 132 is a microchannel through which a dispersed phase flows, 133 is a microchannel through which a first continuous phase flows, and 134 is a microchannel through which a second continuous phase flows, 135 Is a first junction where the dispersed phase and the first continuous phase join, 136 is a second junction where the dispersed phase joins the first continuous phase and the second continuous phase, and 137 is a first continuous phase. 138 is the dispersed phase, 139 is the second continuous phase and 140 is the emulsion produced.

  In this embodiment, at the first junction 135, the dispersed phase 138 and the first continuous phase 137 join to form a two-phase flow of the first continuous phase 137 and the dispersed phase 138. Further, at the second junction 136, the two-phase flow of the first continuous phase 137 and the dispersed phase 138 and the second continuous phase 139 merge. At this time, an emulsion 140 is generated from the dispersed phase 138.

  According to this embodiment, there is an advantage that an emulsion having a small particle size with respect to the channel width can be easily generated.

  FIG. 19 is an explanatory diagram of a microcapsule generation device showing a fourteenth embodiment of the present invention, and FIG. 19 (a) is a schematic diagram showing the entire configuration of the microcapsule generation device, and FIG. 19 (a-1). Is a left side view, FIG. 19 (a-2) is a schematic plan view thereof, and FIG. 19 (a-3) is a right side view thereof. FIG. 19B is an explanatory diagram of the first junction, and FIG. 19C is an explanatory diagram of the second junction.

  In these figures, 141 is a main body of the microcapsule manufacturing apparatus, 142 is a microchannel through which a dispersed phase (for example, water) flows, 143 is a microchannel through which a first continuous phase (for example, oil) flows, and 144 is a second channel. 145 is a first junction where the dispersed phase and the first continuous phase merge, and 146 is a microchannel where the dispersed phase and the first continuous phase and the second continuous phase are merged. 147 is the first continuous phase, 148 is the dispersed phase, 149 is the emulsion (eg, water), 150 is the second continuous phase, 151 is the microcapsules produced, and More than one emulsion 149 can be included in microcapsules 151.

  FIG. 20 is a block diagram of an apparatus for producing a large amount of microdroplets (emulsion / microcapsule) using rubber elastic deformation of the present invention, and FIG. 21 is an explanatory diagram of the operation of the first generator.

  In these figures, 160 is a linear motor, 161 is a liquid tank, 162 is a lid, 163 is a dispersed phase, 164 is an upper stainless plate, 165 is a rubber member, 166 is a lower stainless plate, 167 is a microchannel, and 168 is a continuous phase. , 169 are the produced emulsions (microdroplets). Note that a piezo or other actuator may be used instead of the linear motor 160 as an actuator.

  Then, when the linear motor 160 is driven from above to the liquid tank 161 (see FIG. 21A) to which the back pressure is applied, and pressure is applied, the liquid tank 161 is sandwiched between the upper stainless plate 164 and the lower stainless plate 166. The rubber member 165 is pressed (see FIG. 21B), the dispersed phase 163 is torn off from the microchannel 167 and discharged, and a microdroplet 169 is generated. In this case, by forming many microchannels 167 on the upper stainless plate 164, the rubber member 165, and the lower stainless plate 166, a large amount of microdroplets 169 can be easily generated by driving the linear motor 160 once. Can be done.

  FIG. 22 is an explanatory diagram of the operation of the second apparatus for generating a large amount of micro droplets shown in FIG.

  In this embodiment, a constriction 167B is provided in which a taper 167A is formed in which the lower part of the diameter of the flow path of the plurality of microchannels 167 is narrowed.

  Then, when the linear motor 160 is driven from above into the liquid tank 161 (see FIG. 22A) to which the back pressure is applied and pressure is applied, the liquid tank 161 is sandwiched between the upper stainless plate 164 and the lower stainless plate 166. The rubber member 165 is pressed from above (see FIG. 22B), the dispersed phase 163 is torn off from the microchannel 167 and discharged, and a microdroplet 169 is generated. In this case, since the lower portion of the diameter of the flow channel of the microchannel 167 is narrowed by the taper 167A, there is an effect that the microdroplets 169 are efficiently discharged downward.

  FIG. 23 is an explanatory diagram of the operation of the third apparatus for generating a large amount of microdroplets shown in FIG.

  In this embodiment, a constriction 167E in which a first taper 167C in which the lower part of the diameter of the flow path of the plurality of microchannels 167 is narrowed and a second taper 167D in which the lower part of the diameter of the flow path is further expanded is formed. Is provided.

  Accordingly, when the linear motor 160 is driven from above to apply pressure to the liquid tank 161 (see FIG. 23A) to which the back pressure is applied, the liquid tank 161 is sandwiched between the upper stainless plate 164 and the lower stainless plate 166. The rubber member 165 is pressed from above (see FIG. 23B), the dispersed phase 163 is torn off from the microchannel 167 and discharged, and a microdroplet 169 'is generated. In that case, the microdroplet 169 'is torn off from the microchannel 167 by the first taper 167C, and the microdroplet 169' of the disperse phase is guided downward by the second taper 167D. It has the effect of being more efficiently discharged.

  It should be noted that the present invention is not limited to the above embodiment, and various modifications are possible based on the spirit of the present invention, and these are not excluded from the scope of the present invention.

  ADVANTAGE OF THE INVENTION According to the manufacturing method and the apparatus of the microcapsule of this invention, a microcapsule can be produced | generated easily and quickly, and it is suitable for the manufacturing field of a medicine, and the field of biotechnology.

FIG. 2 is a plan view of the apparatus for manufacturing microdroplets according to the first embodiment of the present invention. FIG. 3 is an explanatory diagram of a method for manufacturing a microdroplet according to the first embodiment of the present invention. It is a top view of the manufacturing device of the microcapsule which shows the 2nd Example of this invention. It is an explanatory view of a manufacturing method of a microcapsule showing a second embodiment of the present invention. It is a top view of the manufacturing device of the micro droplet which shows the 3rd Example of the present invention. It is an explanatory view of a manufacturing method of a microdroplet showing a third embodiment of the present invention. It is a top view of the manufacturing device of the microcapsule which shows the 4th Example of this invention. It is an explanatory view of a manufacturing method of a microcapsule showing a fourth embodiment of the present invention. It is a figure which shows the particle diameter at the time of changing a continuous phase and a dispersed phase height in 4th Example of this invention. It is explanatory drawing of the mechanism which sends out the dispersed phase or the phase enclosed in a shell or the inside of the manufacturing apparatus of the microcapsule which shows 5th Example of this invention. It is explanatory drawing of the mechanism which sends out the dispersed phase or the phase contained in a shell or the inside of the manufacturing apparatus of the microcapsule which shows the 6th Example of this invention. It is explanatory drawing of the mechanism which sends out the dispersed phase or the phase enclosed in a shell or the inside of the manufacturing apparatus of the microcapsule which shows 7th Example of this invention. It is a block diagram of the opening / closing mechanism of the dispersed phase supply port of the manufacturing apparatus of the microcapsule which shows the 8th Example of this invention. It is a block diagram of the opening / closing mechanism of the dispersed phase supply port of the microcapsule manufacturing apparatus showing the ninth embodiment of the present invention. It is a block diagram of the opening / closing mechanism of the dispersed phase supply port of the manufacturing apparatus of the microcapsule which shows the 10th Example of this invention. It is a top view of an emulsion manufacturing device showing an eleventh embodiment of the present invention. It is a top view of an emulsion manufacturing device showing a twelfth embodiment of the present invention. It is an explanatory view of an emulsion generating apparatus showing a thirteenth embodiment of the present invention. It is an explanatory view of a microcapsule generation device showing a fourteenth embodiment of the present invention. It is a block diagram of the mass production apparatus of the minute droplet using the rubber elastic deformation of the present invention. 21 is an explanatory diagram of the operation of the first large-volume microdroplet generation device shown in FIG. 20. FIG. 21 is an explanatory diagram of the operation of the second apparatus for generating a large amount of micro droplets shown in FIG. 20. FIG. 21 is an explanatory diagram of the operation of the third apparatus for generating large amounts of microdroplets shown in FIG.

Claims (7)

For the continuous phase flowing in the microchannel, a shell phase and a phase contained therein are supplied in a direction intersecting the flow of the continuous phase, and the shell phase becomes a phase contained in the interior. A method for producing microcapsules, characterized in that microcapsules are obtained by supplying a thin layer from the upstream side. With respect to the first and second continuous phases flowing in the first and second microchannels formed on both sides, the phase contained therein is oriented in a direction crossing the flow of the first and second continuous phases. To form microdroplets contained therein, and then, with respect to the third and fourth continuous phases flowing through the third and fourth microchannels, the shell phases are changed to the third and fourth phases. 4. A method for producing microcapsules, characterized in that microcapsules are obtained by supplying to a confluence point with the continuous phase of No. 4 in a direction intersecting the flow and forming microdroplets serving as shells. The first continuous phase and the dispersed phase merge at a first junction to generate microdroplets, and the first continuous phase including the microdroplets further forms a second continuous phase and a second junction at a second junction. A method for producing microcapsules, comprising forming microcapsules containing the microdroplets in the first continuous phase by merging. Means for generating a continuous phase flowing in the microchannel, means for supplying a shell phase and a phase contained therein in a direction intersecting the flow of the continuous phase, and the shell phase is provided in the interior. Means for supplying a thin layer from the upstream side to the phase contained therein. With respect to the first and second continuous phases flowing in the first and second microchannels formed on both sides, the phase contained therein is oriented in a direction crossing the flow of the first and second continuous phases. To form microdroplets contained therein, and then, with respect to the third and fourth continuous phases flowing in the third and fourth microchannels, the shell phases are replaced with the third and fourth phases. 4. An apparatus for producing microcapsules, comprising: means for supplying microcapsules to a junction point with the continuous phase of No. 4 in a direction intersecting the flow and forming a shell coating. 6. The microcapsule manufacturing apparatus according to claim 4, wherein the means for supplying a plurality of shell phases and a phase contained therein are disposed between a substrate, a driven plate, and the substrate and the driven plate. An apparatus for producing microcapsules, comprising: an elastic member and an actuator for driving the driven plate, wherein the plurality of shell phases and the phase contained therein are simultaneously supplied. 6. The microcapsule manufacturing apparatus according to claim 4, wherein microdroplets are easily generated on the inner wall surfaces of the microchannel and the dispersed phase supply channel near which the continuous phase and the dispersed phase merge. An apparatus for producing microcapsules, wherein such a film is formed.

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