JP2004255053A - Medical fluid injection method and apparatus therefor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To enable infusional administration of a medical fluid directly into an intended position of a specified injection object such as an affected area of the human body without using an injection needle or the like. <P>SOLUTION: The medical fluid of a therapeutic agent or the like is dissolved into a physiological saline solution and is frozen and solidified by freezing. The medical fluid in the solidified state can be rapidly injected into the predetermined position of the predetermined injection object such as the affected area of the human body. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a method and an apparatus for injecting a drug such as a therapeutic drug into a predetermined injection target such as an affected part.
[0002]
[Prior art]
2. Description of the Related Art Conventionally, in order to administer a therapeutic agent to an affected part, for example, in treating a disease or the like, a method of oral administration or a method of using a syringe has been generally adopted (for example, see Patent Document 1).
[0003]
[Patent Document 1]
WO 98/48871 (pages 1-16, FIGS. 1 and 2)
[0004]
[Problems to be solved by the invention]
However, a problem with the oral administration method is that side effects are strong. In particular, since the drug passes through the digestive organs such as the stomach, it is necessary to enhance safety, and therefore, components that are unnecessary for treatment are included.
[0005]
On the other hand, the administration method by injection involves pain and is not suitable for frequent administration. Further, after the injection, the medicinal solution component is distributed throughout the body by the blood flow, so that the amount to be administered to the affected area requiring treatment is reduced, and the treatment efficiency is low.
[0006]
In addition, in the case of these conventional methods, it is necessary to simultaneously take another drug for suppressing the above-mentioned side effects, depending on the kind of the drug.
[0007]
The present invention has been made in order to solve these problems. A medical solution (liquid or solid) such as a therapeutic agent is dissolved in physiological saline, then frozen and solidified, and a predetermined amount of a target to be pressed into an affected part or the like is injected. It is an object of the present invention to provide a method and an apparatus for injecting a drug solution, in which a medicine can be effectively administered to a predetermined site such as an affected area by press-fitting the site at a high speed.
[0008]
[Means for Solving the Problems]
The present invention has the following problem solving means in order to achieve the above object.
[0009]
(1) First Problem-Solving Means A first problem-solving means of the present invention is to dissolve a drug solution such as a therapeutic agent in physiological saline, and then freeze and solidify the solution by freezing. It is characterized in that it is press-fitted at a high speed into a predetermined part to be press-fitted such as an affected part.
[0010]
In general, most drug solutions such as therapeutic agents are water-soluble, so that they can be frozen and frozen by including water.
[0011]
Therefore, according to the above-described method for injecting a drug, a drug such as a therapeutic drug can be directly injected into a required part of a predetermined press-fit target such as an affected part requiring treatment without using an injection needle.
[0012]
(2) Second Problem-Solving Means A second problem-solving means according to the present invention is that, in the structure of the first problem-solving means, the surface of the solidified chemical solution is heated and melted immediately before press-fitting. Features.
[0013]
When the frozen and solidified drug solution is press-fitted in this way, for example, when used for human treatment, friction with the skin or muscle at the time of press-fitting can be reduced as much as possible, and pain is almost eliminated. Becomes possible.
[0014]
(3) Third Problem-Solving Means The third problem-solving means of the present invention, in the configuration of the first or second problem-solving means, adjusts the press-fitting speed at the time of press-fitting to thereby apply a target such as an affected part. It is characterized in that it can be pressed into a desired depth position.
[0015]
According to such a configuration, it is possible to reliably administer to an affected part at an arbitrary position in the body, such as an affected part of the human body, by using the affected part position specifying means such as CT and MRI together.
[0016]
(4) Fourth Problem Solving Means A fourth problem solving means of the present invention is a freezing / freezing means for freezing and solidifying a drug solution such as a therapeutic drug dissolved in physiological saline, and a freezing / solidifying means by the freezing / freezing means. It is characterized by comprising a liquid medicine press-fitting means for press-fitting a given liquid medicine at a high speed into a predetermined portion to be press-fitted such as an affected part.
[0017]
Generally, most of the therapeutic agents are water-soluble, and can be frozen and frozen by including water.
[0018]
Therefore, according to the above-described method for injecting a drug, a drug such as a therapeutic drug can be directly injected into a necessary part such as an affected part requiring treatment without using an injection needle.
[0019]
(5) Fifth Problem Solving Means A fifth problem solving means of the present invention is the fourth problem solving means, wherein a heating means for heating and melting the surface of the solidified chemical solution immediately before press-fitting is provided. It is characterized by.
[0020]
When the frozen and solidified drug solution is press-fitted in this way, for example, when used for human treatment, friction with the skin or muscle at the time of press-fitting can be reduced as much as possible, and pain is almost eliminated. Becomes possible.
[0021]
(6) Sixth Problem Solving Means A sixth problem solving means of the present invention is the above-described fourth or fifth problem solving means, wherein a press-fit speed adjusting means for adjusting a press-fitting speed at the time of press-fitting is provided. It is characterized in that it can be press-fitted to a desired depth position of a press-fit target such as an affected part.
[0022]
According to such a configuration, it is possible to reliably administer to an affected part at an arbitrary position in the body, such as an affected part of the human body, by using the affected part position specifying means such as CT and MRI together.
[0023]
【The invention's effect】
According to the chemical solution injection method and apparatus as described above, the following advantages can be obtained.
[0024]
{Circle around (1)} In oral administration, drugs with strong side effects can be directly administered to the affected area. Therefore, it becomes safe and does not require a drug for separately suppressing side effects.
[0025]
(2) It is also possible to administer to a very small affected area (the advantage of a very small size).
[0026]
(3) It is possible to administer to moving parts such as muscles (the advantage of high speed).
[0027]
(4) It is possible to administer a drug with low stability (advantage of high speed).
[0028]
{Circle around (5)} It is also possible to administer to hard objects such as trees and animals with hard skin (the advantages of needlelessness, micro size and bottom friction).
[0029]
BEST MODE FOR CARRYING OUT THE INVENTION
(Embodiment 1)
FIGS. 1 to 5 also show the configuration of a drug solution injection method according to Embodiment 1 of the present invention and a drug solution injection device that performs the drug solution injection method.
[0030]
FIG. 1 shows the entire configuration thereof, and reference numeral 1 denotes a drug solution storage layer for a therapeutic drug or the like. In the drug solution storage layer 1, a drug solution C is stored in a state dissolved in physiological saline. ing.
[0031]
The chemical solution (therapeutic drug and the like) C is pumped by the metering pump 3 as needed, and supplied to the chemical solution freezing units 51a to 51d of the chemical solution press-fitting means 5 via the chemical solution supply line 2. ing. Each of the chemical liquid freezing units 51a, 51b, 51c, 51d of the chemical liquid press-in means 5 forms frozen liquids (chemical liquid frozen bodies) 52a, 52b, 52c, 52d of a shape and a dimension order as shown in FIG. And a cooling element 53, 53, 53, 53 for freezing the chemical solution, and a cooling element 53, 53, 53, 53 for freezing the chemical solution. Heating elements 54, 54, 54, 54 are provided for heating and melting the surfaces of the frozen drug solution frozen bodies 52a, 52b, 52c, 52d immediately before press-fitting.
[0032]
On the other hand, reference numeral 10 denotes high-pressure air generating means such as a high-pressure pump. The high-pressure air generated by the high-pressure air generating means 10 is supplied to high-pressure air supply lines 11, 11 a, 11 b, 11 c having an electromagnetic valve 12. , 11d are supplied to the rear end side of the chemical liquid freezing units 51a, 51b, 51c, 51d. The supply / stop is performed by, for example, opening and closing the electromagnetic on-off valve 12 controlled via a control unit such as a microcomputer.
[0033]
(Chemical solution injection method)
Next, a description will be given of a drug solution injection method performed using the drug solution injector configured as described above.
[0034]
That is, first, the drug solution C dissolved in physiological saline is supplied from the drug solution storage layer 1 to the respective drug solution freezing units 51a, 51b, 51c, 51d by the metering pump 6 in predetermined amounts. Next, they are frozen by the cooling elements 53, 53, 53, 53 into frozen chemicals 52a, 52b, 52c, 52d having the size and shape as shown in FIG.
[0035]
Next, in this state, the high-pressure air generating means 10 is operated as needed, and the above-mentioned electromagnetic on-off valve 12 is opened. At a slightly earlier timing, the heating elements 54, 54, 54, 54 are operated to melt the surfaces of the frozen chemicals 52a, 52b, 52c, 52d as shown in FIG. Then, high-pressure air is instantaneously supplied to the rear of each of the chemical liquid freezing units 51a, 51b, 51c, 51d, and the chemical liquid frozen bodies 52a, 52b, 52c, 52d in the chemical liquid freezing units 51a, 51b, 51c, 51d. At the same time, the drug solution freezing units 51a, 51b, 51c, and 51d jump out of the tips 55, 55, 55, and 55 of the same body at high speed, and for example, are pressed into the corresponding affected part 7 of the body 6b of the human body 6 through the skin 6a.
[0036]
At the time of this press-fitting, the press-fitting speed can be arbitrarily adjusted and set, for example, by changing the pressure value of the supplied high-pressure air, whereby the affected portion at a desired depth in the human body 6 can be set. The liquid medicine frozen bodies 52a, 52b, 52c and 52d are appropriately injected and injected so as to reach and stay there.
[0037]
The frozen drug solutions 52a, 52b, 52c, 52d thus administered to the diseased part 7 are quickly melted by body temperature, as shown in FIG. 5, for example, and act on the diseased part very effectively.
[0038]
In the configuration of FIG. 1 described above, only four sets of chemical solution freezing units 51a to 51d of the chemical solution holding unit 5 are provided, but these are actually, for example, as shown in FIG. The number of units that can hold 2500 chemical liquid frozen bodies 52a, 52b,... Having a chemical liquid amount of 2 μg as shown in FIG. 2 is set in the chemical liquid holding section 5 (total chemical liquid amount 5 mg).
[0039]
Of course, these numbers and amounts are arbitrary.
[0040]
As described above, in the method for injecting a drug solution according to Embodiment 1 of the present invention, a drug solution such as a therapeutic agent is dissolved in physiological saline, and then frozen and solidified by freezing. It is characterized in that it is press-fitted at a high speed into a predetermined portion to be press-fitted at a high speed.
[0041]
In general, most drug solutions such as therapeutic agents are water-soluble, so that they can be frozen and frozen by including water.
[0042]
Therefore, according to the above-described method for injecting a drug, a drug such as a therapeutic drug can be directly injected into a required part of a predetermined press-fit target such as an affected part requiring treatment without using an injection needle.
[0043]
Further, the method is characterized in that, in the above configuration, the surface of the solidified chemical solution is heated and melted immediately before press-fitting.
[0044]
When the frozen and solidified drug solution is press-fitted in this way, for example, when used for human treatment, friction with the skin and muscles can be reduced as much as possible, and almost pain can be eliminated. Become.
[0045]
Further, this method is characterized in that, in the above configuration, the press-fitting speed at the time of press-fitting is adjusted so that the press-fitting can be performed at a desired depth position of the press-fitting target such as an affected part.
[0046]
According to such a configuration, it is possible to reliably administer to an affected part at an arbitrary position in the body, such as an affected part of the human body, by using the affected part position specifying means such as CT and MRI together.
[0047]
In addition, the drug solution injection device according to Embodiment 1 of the present invention includes a freezing / freezing means for freezing and solidifying a drug solution such as a therapeutic drug dissolved in physiological saline as described above, and a freezing / solidifying means using the freezing / freezing means. It is characterized by comprising a liquid medicine press-fitting means for press-fitting a given liquid medicine at a high speed into a predetermined portion to be press-fitted such as an affected part.
[0048]
Generally, most of the therapeutic agents are water-soluble, and can be frozen and frozen by including water.
[0049]
Therefore, according to the above-described method for injecting a drug, a drug such as a therapeutic drug can be directly injected into a necessary part such as an affected part requiring treatment without using an injection needle.
[0050]
Further, the apparatus is characterized in that, in the above configuration, heating means for heating and melting the surface of the solidified chemical solution immediately before press-fitting is provided.
[0051]
When the frozen and solidified drug solution is press-fitted in this way, for example, when used for human treatment, friction with the skin or muscle at the time of press-fitting can be reduced as much as possible, and pain is almost eliminated. Becomes possible.
[0052]
Further, the apparatus is characterized in that, in the above configuration, a press-fitting speed adjusting means for adjusting the press-fitting speed at the time of press-fitting is provided so that the press-fitting can be performed at a desired depth position of the press-fitting target such as an affected part.
[0053]
According to such a configuration, it is possible to reliably administer to an affected part at an arbitrary position in the body, such as an affected part of the human body, by using an affected part position specifying means such as CT and MRI.
[0054]
Therefore, according to the above-described method and apparatus for injecting a chemical solution, the following advantages can be obtained.
[0055]
{Circle around (1)} In oral administration, drugs with strong side effects can be directly administered to the affected area. Therefore, while being safe, a drug for separately suppressing side effects is not required.
[0056]
(2) It is also possible to administer to a very small affected area (the advantage of a very small size).
[0057]
(3) It is possible to administer to moving parts such as muscles (the advantage of high speed).
[0058]
(4) It is possible to administer a drug with low stability (advantage of high speed).
[0059]
{Circle around (5)} It is also possible to administer to hard objects such as trees and animals with hard skin (the advantages of needlelessness, micro size and bottom friction).
[0060]
(Embodiment 2)
Next, FIG. 6 shows a configuration of a drug solution injection method and a drug solution injection device according to Embodiment 2 of the present invention.
[0061]
In this embodiment, a highly stable chemical solution A (reservoir 1A) and a highly stable chemical solution B (reservoir 1B) are supplied to the synthesizing device 8 via the respective chemical solution supply lines 2a and 2b. The synthetic device 8 is used to synthesize a therapeutic agent having high activity and low stability, and thereafter the affected part of the human body 6 in the body 6b of the human body 6 via the single chemical solution supply line 4 through the same chemical solution press-fitting means 5 as described above. It is characterized in that seven parts are sequentially injected and administered.
[0062]
According to such a drug solution injection method and device, for example, in an oral ingestion method or a blood vessel injection method, a highly active and low-stability therapeutic drug (A + B) that is decomposed by the time the drug solution reaches the affected area is applied to the affected area. To be administered quickly and directly.
[0063]
(Embodiment 3)
Further, FIG. 7 shows a configuration of a drug solution injection method and a drug solution injection device according to Embodiment 3 of the present invention.
[0064]
In this embodiment, when increasing the dose of the drug solution for one shot, without increasing the number of frozen drug solutions as described above, from one of the drug solution freezing units 50 of the drug solution press-fitting means 5 portion, It is characterized by the fact that it is injected continuously.
[Brief description of the drawings]
FIG. 1 is a diagram showing an entire configuration of a drug solution injection method and a drug solution injection device according to Embodiment 1 of the present invention.
FIG. 2 is an enlarged view showing a configuration of a frozen drug solution in the drug solution injection method and the drug solution injection device.
FIG. 3 is an enlarged view showing a configuration of a drug solution holding unit when adding a drug solution freezing unit in the drug solution injection method and the drug solution injection device.
FIG. 4 is a cross-sectional view showing the structure of the frozen liquid body in the surface-melted state in the liquid medicine injection method and the liquid medicine injection device.
FIG. 5 is an enlarged explanatory view showing a state in which the liquid medicine is melted after the frozen liquid body enters the body in the liquid medicine injection method and the liquid medicine injection device.
FIG. 6 is a diagram illustrating a configuration of a drug solution injection method and a drug solution injection device according to Embodiment 2 of the present invention.
FIG. 7 is a diagram showing a configuration of a chemical solution injection method and a chemical solution injection device according to Embodiment 3 of the present invention.
1 is a chemical storage layer, 5 is a chemical liquid injection means, 3 is a metering pump, 6 is a human body, 7 is an affected part, 10 is a high pressure air generating means, 12 is an electromagnetic on-off valve, 51a to 51d are chemical liquid freezing units, and 52a to 52d are A frozen drug solution, 53 is a cooling element for freezing the drug solution, and 54 is a heating element for melting the surface of the drug solution.

Claims (6)

After a drug solution such as a therapeutic drug is dissolved in physiological saline, it is frozen and solidified by freezing, and in the solidified state, it is press-fitted at a high speed to a predetermined site of a target such as an affected part. How to inject chemicals. 2. The method according to claim 1, wherein the surface of the solidified chemical solution is heated and melted immediately before press-fitting. 3. The method according to claim 1, wherein the press-fitting speed at the time of press-fitting is adjusted so that the press-fitting can be performed at a desired depth position of the press-fitting target such as an affected part. Freezing and freezing means for freezing and solidifying a drug solution such as a therapeutic drug dissolved in physiological saline, and a drug solution press-in means for press-fitting the drug solution frozen and solidified by the freezing / freezing means at a high speed into a predetermined site to be pressed into an affected part or the like. A chemical liquid injection device characterized by comprising: 5. The chemical injection device according to claim 4, further comprising a heating means for heating and melting the surface of the solidified chemical immediately before the press-fitting. 6. The liquid injector according to claim 4, wherein a press-in speed adjusting means for adjusting a press-in speed at the time of press-in is provided so that the press-in can be performed at a desired depth position of a target to be press-fitted such as an affected part.

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