JP2004248949A - Wound covering material - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a wound covering material made by drying into a film form a consistent liquid containing one kind or two kinds or more selected from the group consisting of (A) glucomannan, (B) pullulan, carrageenan or chitosan, and (C) polyhydric alcohol, sugar alcohol, monosaccharide, disaccharide and oligosaccharide by a method for easily industrially manufacturing and handling. <P>SOLUTION: A laminated sheet is made by sticking a holding layer made of a cotton mesh type nonwoven fabric to the polyolefin side of the film made by laminating a nondrawn polyolefin onto a base material layer composed of polyester or nylon, the holding layer of the laminated sheet is impregnated with a viscous liquid containing one or two or more kinds selected from the group consisting of (A) the glucomannan, (B) the pullulan, the carrageenan or the chitosan and (C) the polyhydric alcohol, the sugar alcohol, the monosaccahride, the disaccharide and the oligosaccahride at a rate of 3 to 15 g/m<SP>2</SP>in dry weight. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention contains one or more selected from the group consisting of A) glucomannan, B) pullulan, carrageenan or chitosan and C) polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides. The present invention relates to a wound dressing which is formed by drying a viscous liquid into a film, and which can be provided by an industrially easy and easy-to-handle method.
[0002]
[Prior art]
Japanese Patent Publication No. 2-34618 discloses that A) glucomannan, B) pullulan, carrageenan or chitosan and C) one or more selected from the group consisting of polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides. A film-shaped wound dressing obtained by drying a viscous liquid containing two or more types is disclosed. When this wound dressing was actually applied to the affected area, the exudate from the affected area effectively acted on the affected area, the formation of the dermis was promoted, and excess water was released, which proved to be an ideal wound dressing.
However, a viscous composition containing A) glucomannan, B) pullulan, carrageenan or chitosan and C) one or more selected from the group consisting of polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides The liquor contains about 95% water and it is difficult to dry this large amount of water. Even if it is dried, it is brittle and has problems in distribution, storage and use thereafter.
[0003]
[Problems to be solved by the invention]
Therefore, an attempt was made to apply and dry a holding material such as a gauze or a nonwoven fabric made of natural fibers, but it was still difficult to dry and handle. It is preferable to adhere a holding layer such as a gauze or a nonwoven fabric to the polyester base material because of the film tension. However, the compatibility between the polyester base material and the nonwoven fabric is poor, and the product has not been manufactured industrially. An object of the present invention is to provide and provide a wound dressing containing glucomannan, pullulan or chitosan and a polyhydric alcohol in a form which can be industrially handled.
[0004]
[Means for Solving the Problems]
The structure of the present invention is a laminated sheet obtained by bonding a woven fabric, a nonwoven fabric or a knitted fabric made of natural fibers as a holding layer to a polyolefin surface of a film obtained by laminating an unstretched polyolefin on a base layer made of polyester or nylon. And wherein in the holding layer of the laminated sheet, one or more selected from the group consisting of A) glucomannan, B) pullulan, carrageenan or chitosan and C) polyhydric alcohol, sugar alcohol, monosaccharide, disaccharide and oligosaccharide A viscous liquid containing two or more kinds is impregnated and dried, and the holding layer is a mesh-type nonwoven fabric made of cotton, and the viscous liquid is impregnated with 3 to 15 g / m ² by dry weight. It is characterized in that, when bonding the holding layer to the polyolefin surface with an adhesive, the holding layer and the polyolefin layer can be peeled after applying a viscous liquid and drying It is characterized by being adhered to.
[0005]
That is, the present invention is selected from the group consisting of A) glucomannan, B) pullulan, carrageenan or chitosan and C) polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides. A protective layer impregnated with a viscous liquid containing one or more of the above is formed on a laminate of a polyolefin and a substrate made of a polyester or nylon film with tension, and held with the polyolefin layer when necessary. The layer is peeled off and used. In order to maintain the film forming property and strength of the viscous liquid, absorb the viscous liquid into a holding layer such as a woven fabric, nonwoven fabric or knitted fabric made of natural fiber, and protect it with a polyester or nylon base material with tension. It is provided for production, distribution, and storage.
[0006]
The membrane composed of the natural fiber holding layer that has absorbed the viscous liquid is soft and has a mushy feel, so that it has a poor affinity for the base film with tension and is difficult to handle as a single unit during production. In the present invention, a film obtained by laminating a polyolefin, preferably unstretched polypropylene on a base film such as polyester is used as an intermediate layer, and a layer of natural fibers is bonded to the intermediate layer with an adhesive. The viscous liquid is absorbed and held in the holding layer, and is passed through a heating device and dried industrially. The holding layer made of natural fibers is primarily bonded to the polyolefin layer with an adhesive, but the affinity for the polyolefin layer is not sufficient, so that the natural fiber layer and the polyolefin layer can be easily peeled off before use. The component of the viscous liquid is integrated with the natural fiber layer to form a film, and can be used as it is by attaching it to a wound.
[0007]
BEST MODE FOR CARRYING OUT THE INVENTION
The component A) glucomannan used in the present invention is a heteroglucan in which D-glucose and D-mannose obtained from the rhizome of konjac potato are linked by β-1,4 bonds at a molar ratio of about 2: 3 by β-1,4 bonds. .
The pullulan belonging to the component (B) is a linear glucan generally produced by an incomplete bacterium called black yeast, and commercially available pullulan having a molecular weight of about 200,000 is preferably used. Carrageenan is a sulfate of a polysaccharide obtained from seaweed and has three known structures, κ, λ, and ι. Carrageenan used in the present invention contains some κ-type carrageenan. Chitosan is obtained by deacetylation of chitin.
The ratio of glucomannan to the component B), pullulan, carrageenan or chitosan is 0.2 to 1 part by weight, preferably 0.5 to 0.8 part by weight of pullulan, carrageenan or chitosan per 1 part by weight of glucomannan. . If the amount of pullulan, carrageenan or chitosan exceeds 1 part by weight with respect to 1 part by weight of glucomannan, the obtained wound dressing becomes easily soluble in water, and the exudate tends to disintegrate the membrane layer of the wound dressing at the wound site. . On the other hand, if the amount of pullulan, carrageenan or chitosan is less than 0.2 parts by weight, the gel will have a high viscosity, and the film will not have the required elasticity, flexibility and adhesiveness as a wound dressing material.
[0009]
Examples of the component (C) include polyhydric alcohols such as propylene glycol, glycerin, ethylene glycol, diethylene glycol, and dipropylene glycol. Sugar alcohols include sorbitol, mannitol, maltitol, xylitol and the like. Monosaccharides include glucose, fructose, maltose, lactose and the like, and disaccharides include saccharose, maltose, lactose and the like. Examples of the oligosaccharides include starches such as sweet potatoes, potatoes, and corns, which are decomposed by enzymes or acids. One or more of these components C) are used.
The amount of the component C is 0.2 to 20 parts by weight, preferably 0.5 to 15 parts by weight, based on 1 part by weight of glucomannan. If the amount is less than 0.2 parts by weight, sufficient flexibility and elasticity to adhere to the skin cannot be obtained, and if it exceeds 20 parts by weight, the water solubility of the wound dressing increases, and the wound site exudes swelling and impairs the functionality. .
[0010]
The above are essential components, but a rubber-based adhesive and an acrylic-based adhesive are used as necessary. As the rubber-based pressure-sensitive adhesive, polybutene and polyisobutylene having an average molecular weight of 100,000 or less are particularly preferable. In the acrylic pressure-sensitive adhesive, a homo- or copolymer of alkyl acrylate is preferably used, and as the alkyl group, methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, 2-ethylhexyl, nonyl, isononyl, etc. Acrylic esters of alkyl groups having a straight or branched chain can be mentioned.
The amount of the rubber-based pressure-sensitive adhesive and the acrylic-based pressure-sensitive adhesive to be used is 0.1 to 12 parts by weight, preferably 0.3 to 6 parts by weight, per 1 part by weight of glucomannan.
[0011]
The viscous liquid of the present invention contains about 95% of water because it contains glucomannan and other polysaccharides, and it is difficult to vaporize the water to industrially dry the film uniformly. Therefore, a film was formed by absorbing a natural fiber such as a woven fabric, a nonwoven fabric, or a knitted fabric into a holding layer. As the natural fiber, cotton is preferable, but hemp, silk and the like can also be used. Since the material is applied to a wound site, a fiber derived from a natural product having an affinity for a living body is preferable. Since the woven fabric and the knitted fabric are formed into a sheet after being formed into a thread, the thread is generally dense in fibers, and there is a portion where the fibers are sparse in a wide range between the threads. Commercially available gauze and the like have a limit in the amount of viscous liquid that can be retained in this sparse site. In particular, a gauze in which fine threads are densely woven can be used, but a nonwoven fabric is generally preferred.
[0012]
Since the nonwoven fabric is not twisted, the fibers are evenly scattered. Therefore, it absorbs more water per unit area than a woven fabric, and can absorb many viscous liquids. On the other hand, in order to treat a wound, a layer consisting of a dried viscous liquid alone is preferred. When a mesh-type nonwoven fabric is used, portions where no or few fibers are present are scattered, and these portions positively contribute to wound treatment. If the pores of the mesh are too large, the viscous liquid cannot be retained in a portion where no fiber exists, and a blank portion may be generated. Therefore, it is important to properly maintain the size and density of the holes in the mesh.
[0013]
The coating thickness of the viscous liquid is 3 to 15 g / m ² , preferably 4 to 12 g / m ² by dry weight. If it is less than 3 g / m ² , the therapeutic effect as a wound dressing material is not sufficient, and if it exceeds 15 g / m ² , the release of water is not sufficient. That is, although the wound dressing of the present invention is not moisture permeable, it absorbs excess water leached from the wound because it is a dried polysaccharide, and diffuses throughout the polysaccharide to be released from the other surface. If the film thickness is too thick, the diffusion of the absorbed water is not performed smoothly, and the wound contact surface becomes dull and a sufficient therapeutic effect cannot be obtained.
[0014]
In the present invention, in the case of industrial production, it is necessary to hold the material to a tight material, and a polyester or nylon base material is used. As the polyester or nylon substrate, a commercially available film can be used.
In the present invention, a laminate obtained by laminating a polyolefin layer on the substrate layer is used. Polyolefin is heat-sealable and has intermediate flexibility between the base layer and the holding layer. By interposing the polyolefin layer, the holding layer can be laminated to the base layer and adapted to mass production. Became. Lamination of the polyolefin layer is not particularly limited, and a lamination method of a film may be used, or an extrusion lamination method of a polyolefin may be used.
As the polyolefin, unstretched polypropylene is generally used, but low-density polyethylene is also preferably used.
[0015]
In bonding the polyolefin layer and the holding layer, all adhesives having an adhesive strength capable of easily separating the holding layer from the polyolefin layer during the application, drying, distribution and storage of the pressure-sensitive adhesive of the present invention are used. Can be used. Actually, a two-component reaction type polyurethane adhesive which reacts a polyester resin with a polyisocyanate is preferably used.
The laminated sheet obtained by laminating the polyester or nylon layer thus obtained, the polyolefin layer and the holding layer is wound around a roll and stored.
[0016]
In the viscous liquid of the present invention, other medicinal components such as a bactericide, a bacteriostatic agent, an active oxygen remover, a granulation formation promoter and the like can be previously blended. Specific examples include astaxanthin, fucocyanin, chlorophyll, riboflavin and the like.
[0017]
In impregnating the viscous liquid of the present invention into the holding layer, a viscous liquid adjusted to have a viscosity of 1200 cp to 3000 cp is charged into a viscous liquid tank. Then, the wound laminated sheet is unwound, passed through the viscous liquid, and pulled up in the vertical direction. Next, the sheet is turned in a horizontal direction via a roller so that the holding layer is on the upper side, and the viscous liquid is dried while the sheet is moving in the horizontal direction, and is wound up by a take-up roll.
A doctor blade is provided while the laminated sheet rises vertically to maintain the amount of the viscous liquid impregnated in the holding material constant and uniform. The viscous liquid is dried by passing through a drying device while the laminated sheet moves horizontally.
[0018]
Since the viscous liquid has a water content of about 95%, it is difficult to dry it all at once. In the present invention, three dryers are arranged horizontally in series and dried in three stages. After passing through the first dryer, once it comes into contact with the atmosphere, it enters the next dryer and is exposed to high heat. As a result of the experiment, when the first dryer was dried at 80 ± 5 ° C., the second dryer was dried at 90 ± 5 ° C., and the third dryer was dried at 100 ± 5 ° C., the drying efficiency and the finished state Both were found to be good.
[0019]
【Example】
Example 1
Unstretched polypropylene having a thickness of 40 μm was dry-laminated on a polyester film having a thickness of 12 μm. A nonwoven fabric of a mesh type with 100% cotton and a basis weight of 30 g / m ² was adhered to the laminate as a holding layer. In this nonwoven fabric, extremely sparse sites were scattered on the entire surface of the sheet, and the number was 40 to 60 / cm ² . In bonding, AD-502 manufactured by Toyo Morton Co., Ltd. was used as an adhesive. This uses 10 parts by weight of CAT-10L, a curing agent composed of polyisocyanate, mixed with 100 parts by weight of polyester resin AD-502. The three-layer laminated sheet thus obtained was wound around a roll.
[0020]
On the other hand, 2.1 parts by weight of glucomannan, 1.4 parts by weight of pullulan, 5 parts by weight of a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, 3 parts by weight of glycerin and 90 parts by weight of purified water are swollen at room temperature. And then occasionally stirred to obtain a viscous gel after 1 hour.
The gel was charged into a viscous liquid tank, the wound three-layer laminated sheet was unwound, passed through a viscous liquid tank, and the holding layer was impregnated with the viscous liquid. At this time, the viscosity of the viscous liquid was 2000 cp. The holding material impregnated with the viscous liquid was pulled vertically while adjusting the thickness with a doctor blade, and was conveyed horizontally via a roll with the holding layer face up.
[0021]
Three strong dryers are installed during horizontal transfer, the first one has an internal temperature of 80 ± 1 ° C, the second one has an internal temperature of 90 ± 1 ° C, and the third one has an internal temperature of 100 ± 1 ° C. It was adjusted. The product in which the viscous liquid was dried into a film, the wound dressing, could be wound on a roll at a speed of 3.5 m / min. The component derived from the viscous liquid of this wound dressing had a dry weight of 9.9 g / m ² and a moisture content of 5.9% as bound water.
There was no trouble that the unstretched polypropylene layer and the holding layer were peeled off throughout the viscous liquid coating, drying and winding steps. In addition, the cotton-made holding layer integrated with the dried viscous liquid, which is a substantial wound dressing, could be easily peeled off from the non-stretched polypropylene layer and used.
[0022]
Example 2
A 71-year-old patient who was MRSA-positive for 4 months, had a pressure sore about 6 cm in diameter in the middle of the back, and had a pocket of 2 to 2.5 cm around the hole, was given the wound dressing prepared in Example 1. used. First, the affected area was washed, and the affected area was covered with a wound dressing peeled off from the non-stretched polypropylene layer. Gauze was placed on the affected area and taped. Although the wound dressing of the present invention was initially taut, it immediately absorbed the exudate from the wound surface and adapted to the skin. Two weeks later, the gauze produced a putrefactive odor, but the putrefaction remained only in the gauze. No infection was observed on the skin surface from which the wound dressing of the present invention had been removed, and the transparent dermis was overhanging. After 4 weeks, the pockets had adhered and disappeared, and the skin on the surface had come out from both sides. In addition, MRSA was negative.
[0023]
【The invention's effect】
According to the present invention, it contains one or more selected from the group consisting of A) glucomannan, B) pullulan, carrageenan or chitosan and C) polyhydric alcohol, sugar alcohol, monosaccharide, disaccharide and oligosaccharide. The viscous liquid is dried in the form of a film, and a wound dressing having a remarkable effect on the treatment of a wound can be provided in a practically easy-to-use form, and can be manufactured industrially.

Claims (7)

On a base layer made of polyester or nylon, on a polyolefin surface of a film obtained by laminating an unstretched polyolefin, a woven fabric, a nonwoven fabric or a knitted fabric made of a natural fiber is bonded as a holding layer to form a laminated sheet,
One or two kinds selected from the group consisting of A) glucomannan, B) pullulan, carrageenan or chitosan and C) polyhydric alcohol, sugar alcohol, monosaccharide, disaccharide and oligosaccharide in the holding layer of the laminated sheet. A wound dressing characterized by being impregnated with a viscous liquid containing the above and dried. The wound covering material according to claim 1, wherein the woven fabric, nonwoven fabric or knitted fabric made of natural fibers is a mesh-type nonwoven fabric made of cotton. A viscous liquid containing A) glucomannan, B) pullulan, carrageenan or chitosan and C) one or more selected from the group consisting of polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides. The wound dressing according to claim 1, wherein the wound dressing is impregnated with a dry weight of 3 to 15 g / m ² . The adhesive layer according to any one of claims 1 to 3, wherein the adhesive layer is adhered to the polyolefin surface via an adhesive, the adhesive layer is applied and dried, and then the elastic layer and the polyolefin layer are peelably adhered to each other. The wound dressing described in the above. Viscous liquid containing A) glucomannan, B) pullulan, carrageenan or chitosan and C) one or more selected from the group consisting of polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides. The wound dressing according to any one of claims 1 to 4, wherein a medicinal component is previously blended. A viscous liquid containing A) glucomannan, B) pullulan, carrageenan or chitosan and C) one or more selected from the group consisting of polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides. The wound according to any one of claims 1 to 5, wherein after impregnating the holding layer of the laminated sheet, the wound is pulled vertically above the viscous liquid tank, and then pulled horizontally to dry. Coating material. A viscous liquid containing A) glucomannan, B) pullulan, carrageenan or chitosan and C) one or more selected from the group consisting of polyhydric alcohols, sugar alcohols, monosaccharides, disaccharides and oligosaccharides. In drying, the first, second, and third dryers are sequentially passed through, and the temperature in the first dryer is set to 80 ± 5 ° C., the temperature in the second dryer is set to 90 ± 5 ° C., The wound dressing according to any one of claims 1 to 6, wherein the temperature in the dryer is 100 ± 5 ° C.