JP2004237051A - Blood vessel visualizing method and apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To solve a problem of an unavoidable physical pain of a person to be taken blood who is compelled to put on a tourniquet and distend the blood vessel for confirming the position of the blood vessel in collecting the blood from the person. <P>SOLUTION: At least, a light containing wavelength components of at least 600-1,200 nm is applied on the skin surface for obtaining am image of the blood vessel right under the skin of the person and confirming the puncture position of a blood collecting needle. The spatial distribution of the intensity of the reflected light of the light once entering into the body and intruding deeper than the blood vessel is observed. This method can reduce the effects of the light directly reflected on the skin surface and the light entering into the body but reflected to the outside from the body before reaching the blood vessel. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a method and an apparatus for visualizing a blood vessel when blood is collected from a blood vessel under the human skin through a hollow needle to the outside of the body.
[0002]
[Prior art]
Conventionally, venous blood is collected by the injection method by wrapping an elastic rubber-like cord called a tourniquet around an arm and aiming at a vein that has emerged on the skin when blood flow was temporarily restricted. A needle was punctured into the vein, and then the blood was drawn into the syringe by vacuum suction.
[0003]
In recent years, a chip-shaped blood analyzer having a size of several mm to several cm square, which is provided with a fine needle for collecting blood and has a fine groove channel, various analyzers, and analyzers, has been developed. (Japanese Patent Application Laid-Open No. 2001-258868) The needle of such a chip-shaped blood analyzer is punctured into the skin of a subject, blood is collected from a subcutaneous blood vessel, and the blood is drawn onto the chip. Analyze the concentration of substances (sodium, potassium ions, glucose, urea nitrogen, creatinine, etc.). The chip has been developed for people to use at home and for health management.
[0004]
[Problems to be solved by the invention]
The tourniquet used at the time of ordinary blood collection is used to raise a blood vessel above the skin and to specify a site where a person who collects blood punctures the injection needle as described above. Wrapping and squeezing the tourniquet around the arm is one of the pains to be given to a blood recipient together with the pain when puncturing the injection needle.
[0005]
Further, in the chip-shaped blood analyzer, first, the diameter of the needle is reduced (for example, outer diameter 100 μm, inner diameter 50 μm) in order to suppress pain at the time of puncturing as much as possible, so that rigidity (buckling strength) is reduced. It is very low. In order to effectively mitigate such a decrease in strength, it is desirable to shorten the entire length of the needle, and such a demand is that the amount of blood that remains in the needle at the time of collection and is not used for analysis is reduced. It is important from a viewpoint. When the length of the needle is shortened in this manner, the tip itself comes close to the skin at the time of blood collection, and it is difficult to see blood vessels with the naked eye because the chip assumes that the subject himself collects blood. There was a problem of becoming.
[0006]
Further, as shown in Japanese Patent Application No. 2001-319992, when a needle is punctured into the skin, the skin is raised by reducing the atmosphere of the skin near the needle for the purpose of relieving pain, and the needle is automatically placed on the skin at that time. In particular, it is difficult to see a blood vessel, and in some cases, there is a problem that a needle cannot be guided to the blood vessel and blood cannot be collected.
[0007]
As described above, to suppress discomfort due to the tourniquet at the time of blood collection by normal injection, and to ensure that the subject who is a blood collector when using the chip-shaped blood analyzer confirms the blood vessel position while collecting blood. Therefore, the position of the blood vessel must be monitored in some way when the needle is punctured into the skin.
[0008]
For this purpose, several techniques for visualizing blood vessels have been known. In many of these known examples, light is guided from outside the body to the body, and blood vessel information is obtained from reflected light or transmitted light. For example, near-infrared light having a wavelength of 700 to 1200 nm is applied to a finger or a back of a hand having a relatively small thickness, and an image pickup device such as a CCD (Charge Coupled Device) is arranged on the back side of the light to pass through the body. Observe the spatial distribution of light intensity. (Japanese Patent Application Laid-Open No. 8-164124) Such near-infrared light is often used because it has a relatively small absorption coefficient due to water and hemoglobin in blood constituting the human body and is easily transmitted. The light transmitted through the blood vessels is higher in water and hemoglobin concentration in blood than other parts, and the transmitted light is weakened by absorption, so the image becomes darker. Light transmitted through the portion is relatively not absorbed and has a high intensity, so that a bright image can be obtained. Therefore, a blood vessel image is obtained.
[0009]
Derivation of a blood vessel image by transmission of near-infrared light as described above can be actually used only in a relatively thin portion such as a finger or the back of a hand due to the limitation of the intensity of a light source. In particular, it is difficult to transmit light of sufficient intensity in the upper arm or forearm portion often used for blood collection. Therefore, a method of irradiating a human body with light, invading the human body once, and then capturing light reflected from the irradiated surface again by an image sensor to obtain a blood vessel image is also known. When such reflected light is used, the intensity of the light directly reflected on the skin surface is strong, and the light intensity which enters the human body once and is reflected again from the human body is compared. In order to catch only light containing blood vessel information (light that has once entered the human body and reflected), in the case of this known example, a liquid is applied to the surface of the skin to be irradiated with light to reduce directly reflected light. Like that. In addition, the skin is irradiated with two types of light having different wavelengths from 400 to 600 nm and from 600 to 800 nm, and the former uses less light components that once enter the body and then reflect again compared to the latter. A method of obtaining a blood vessel image by subtracting the images obtained by both methods is also known. (JP-A-8-164123)
[0010]
As described above, when a blood vessel image is obtained using light, there is a problem in that the applicable portion is limited in the transmission method. In addition, when the reflection method is used, complicated work such as applying a liquid to the skin surface is required to suppress light directly reflected from the skin surface, and two types of light sources, a filter, and a dichroic are required. There is a problem that an expensive and complicated device including a mirror and an image analysis mechanism is required.
[0011]
The problem to be solved by the present invention is to provide a means for accurately grasping the position of a subcutaneous blood vessel by using an inexpensive apparatus without imposing a physical load on a blood sampling subject.
[0012]
[Means for Solving the Problems]
As described above, when light is guided into the body to obtain a blood vessel image, it is preferable to use a reflection method that does not select a site where the image is obtained. In FIG. 1, a human forearm 101 is irradiated with an LED (Light Emitting Diode) 102 as a light source, and light reflected at that time is captured by an image sensor such as a CCD (Charge Coupled Device) 104, and the image thereof is displayed on a monitor 105. Shows the system to be displayed. The wavelength of the light used at this time is 600 to 1200 nm, which has a relatively low absorption coefficient derived from compounds constituting skin and blood vessels, such as skin pigment, blood hemoglobin, and water. FIG. 2 schematically shows how light propagates in the body at this time. Here, the same reference numerals are used for the same components as those described above. Light emitted in this manner includes light 204 reflected on the skin surface and light 205 that once enters the body, diffuses, reflects, and then reflects out of the body again. Caught by The light that once penetrates under blood vessels (mostly veins) near the surface of the skin like the light 205 and then reflects out of the skin again contains blood vessel information, and the blood vessel portion is derived from water and hemoglobin Since the light absorption is larger than that of the other portions, the blood vessel image appears black on the monitor. However, actually, since the intensity of the directly reflected light 204 is large, light information such as 205 is superimposed and hidden on this, and a blood vessel image does not appear on the monitor.
[0013]
In order to reduce the influence of the direct light easily and inexpensively, the present inventors have tried to suppress the direct reflected light by using a direct reflected light shielding device 301 as shown in FIG. In this device, the LED 102 is inserted into the through hole 302, and is pressed against the skin surface near the blood vessel observation site as shown in FIG. At this time, it is desirable that at least the surface of the direct reflection light shielding device 301 be made of a material that does not have transparency to the wavelength of light emitted by the LED 102. When the LED 102 is illuminated in FIG. 4, the light is separated into a component that once penetrates into the body and a component that is directly reflected on the skin surface, as in the case of FIG. 2. However, since the reflected light 204 is directly shielded, it is not captured by the CCD 104. In addition, the light 401 that once penetrates into the body but is reflected without reaching below the blood vessel just below the skin surface is similarly blocked by the device itself and does not go out of the body. Eventually, the light emitted outside the body once penetrates into the body, reaches below the blood vessel just below the skin surface, and then comes out of the body again, and this light is captured by the CCD camera 104, The blood vessel part has a low light intensity due to absorption derived from water, hemoglobin, and the like, and the other parts have a relatively high light intensity, so that a blood vessel image appears dark on the monitor 105. Then, by guiding the injection needle to the blood vessel portion while viewing the blood vessel image, puncturing and blood collection can be easily performed.
[0014]
In the actual blood vessel image, the length of the direct light shielding area 501 of the direct reflection light shielding device 301 shown in FIG. 5 is appropriately set in addition to the intensity of the emitted light of the LED, the aperture of the CCD camera lens, the sensitivity and the gain of the CCD. By doing so, a good product can be obtained. In particular, as described above, the length of the direct light-shielding region is, as described above, light directly reflected on the skin surface and once penetrates into the body, but is reflected without reaching below the blood vessel immediately below the skin surface and radiated outside the body again. It may be set so that light is shielded and light coming out of the body after reaching the blood vessel directly below the skin surface is not blocked again. The light to be shielded such as the directly reflected light is filtered by a filter that absorbs the light emitted by the LED on the surface (excluding the through hole of the LED) including the direct light shielding region 501 in the direct reflected light shielding device. If a film is attached, it can be more reliably removed.
[0015]
BEST MODE FOR CARRYING OUT THE INVENTION
FIG. 6 shows an example of the embodiment of the present invention. As in FIG. 4, the direct-reflection light shielding device 301 to which the LED 102 is attached is attached to the human forearm 101 with the fixing band 601, and a blood vessel image captured by the CCD camera 104 when the LED is irradiated is displayed on the monitor 105. Although not shown, the image obtained by the CCD camera 104 may be processed by software or hardware to obtain a clearer blood vessel image, and then displayed on the monitor 105. Thus, the blood collection syringe 602 is guided near the blood vessel while confirming the blood vessel position, and the injection needle 603 is pierced into the skin to reach the inside of the blood vessel to collect blood.
[0016]
【Example】
[First embodiment]
While observing the vein blood vessel inside the human forearm using the blood vessel observation device using the direct reflection light blocking device shown in FIG. 6, an attempt was made to guide the injection needle to the blood vessel and collect blood. First, as the LED, an LED that emits near-infrared light having an emission center wavelength of 850 nm and a half-value width of 40 nm is used. Also, although not shown, light having a wavelength of 800 nm or less is cut in front of the lens of the CCD camera. The filter which transmits light of the wavelength of was attached. The reason for choosing an LED with such a wavelength is that, as described above, light with a wavelength of about 700 to 1200 nm is easily transmitted through the body, and ordinary inexpensive CCD elements have the most wavelengths of about 500 to 600 nm. This is because it has high sensitivity, and the sensitivity decreases as the wavelength increases. Further, by attaching a filter to the camera, it is possible to observe blood vessels without being affected by visible light even under a fluorescent lamp in a room, and it is not necessary to particularly darken the periphery of the observation site.
[0017]
In this way, the blood vessel image is projected on the monitor 105 as shown in FIG. 6, and the injection needle 603 of the syringe 602 is guided to the appropriate blood vessel by puncturing the skin into the blood vessel. The size of the needle used at this time was 23 gauge, and after introducing the needle into the blood vessel in this way, about 5 cc of venous blood could be collected into the cylinder by applying a negative pressure to the cylinder of the syringe.
[0018]
In addition, an attempt was made to collect blood while observing blood vessels using an apparatus in which a direct-reflection light shielding device 301 equipped with a syringe and an LED as shown in FIG. 7 was integrated. In the same figure, a chip LED 701 (radiation center wavelength: 860 nm, half width: 40 nm) is used for the direct reflection light shielding device 301 in order to reduce the size of the device, and via a syringe barrel 702 and a guide rail 704. The syringe barrel is connected, and can move along the guide rail (in the direction of the arrow in the figure) when the reflected light shielding device is directly fixed. The injection needle 603 used here had a gauge of 23.
[0019]
As shown in the cross-sectional view of FIG. 8A, a device in which the syringe shown in FIG. 7 and the direct-reflection light shielding device to which the LED is attached is integrated is placed on the skin surface 801 of the human forearm. At this time, the needle 603 at the tip of the syringe is set at a position where it does not touch the skin yet, and in this state, the LED 701 is turned on, and the image of the blood vessel 203 and the image of the needle 603 are captured by the CCD camera 104. Although not shown, these are shown on the monitor, and the device that integrates the direct-reflection light shielding device with the syringe and the LED is moved on the skin 801 to a position where the needle can puncture the blood vessel based on the positional relationship between them. After that, as shown in FIG. 13B, the syringe is pushed out to the skin side along the guide rail 704, the needle 603 is punctured into the target blood vessel, and the syringe 703 is introduced after being guided into the blood vessel. By pulling, the blood was able to be sucked and collected in the syringe 702.
[0020]
Conventionally, blood collection was performed by using a tourniquet to inflate blood vessels, but by using the blood vessel visualization apparatus of the present invention, blood can be collected without using a tourniquet. In the above example, the LED element is placed in the direct reflection light blocking device near the skin for irradiation. However, an illumination device such as an LED is placed in the remote location of the skin, and the reflected light is directly blocked by an optical fiber from there. Light may be applied to the skin surface by connecting to the inside of the device.
[0021]
[Second embodiment]
An attempt was made to introduce blood through a painless needle 901 (outside diameter: 100 μm, inside diameter: 60 μm) onto a chip-shaped blood analyzer as shown in FIG. The chip is configured by laminating two polycarbonate substrates, in which a flow path 902 for blood, a sensor electrode 903 for electrochemically sensing the concentration of sodium ion, potassium ion, glucose, and urea nitrogen in blood; And an electrode pad 904 that outputs an electric signal of a sensor output. The chip size is 2 cm square.
[0022]
Next, as shown in FIG. 10A, a tip 1002 is placed on a slider 1001 and fitted into a holder body 1003. A painless needle 901 at the tip of the tip is set in a cylinder 1004 integrated with the holder body. So that Further, similarly to the previous embodiments, the direct reflection light shielding device 301 is installed from the upper arm to the forearm of the human, and the positional relationship with the painless needle 901 at the tip of the tip set in the holder together with the blood vessel image just below the skin. Is captured by the CCD camera 104, and this is confirmed on a monitor, not shown in the figure. At this time, the same LED as that in FIG. 6 is used as a light source of light emitted to the skin. From the positional relationship between the two, the position of the blood collection holder on which the chip is mounted is adjusted, and the painless needle is guided just above the blood vessel to bring the cylinder 1004 into contact with the skin surface. After that, the air is exhausted through the in-cylinder exhaust hose 1005 to reduce the pressure in the cylinder 1004. Then, the painless needle 901 punctures the skin and automatically enters the body. At this time, if the painless needle has reached the blood vessel, it is possible to reduce the pressure in the flow path in the chip via the blood-collecting suction hose 1006 and to guide blood from the blood vessel into the chip. If the needle has not reached the blood vessel, the painless needle 901 is guided deeper into the body while reaching the blood vessel while pushing the slider 1001 toward the skin side and bending the sponge 1007 as shown in FIG. Blood is directed onto the chip as described above.
[0023]
When an attempt was made to collect blood by the above procedure, about 4 μl of blood could be introduced onto the chip. When blood is introduced from a blood vessel into such a chip-shaped blood analyzer, the size of the tip is relatively small and the length of the needle is shorter than that of a blood sampling needle in a normal injection method. There may not be enough room to observe painless needles and blood vessel images. In addition, since the blood vessel image projected on the monitor is dark, if a needle overlaps the blood vessel image, the needle cannot be clearly confirmed, and the positional relationship between the blood vessel image and the needle may not be confirmed. In such a case, a chip LED 701 is attached to the cylinder 104 as shown in FIG. 11 and is turned on to irradiate the painless needle 901 with light so that the needle can be clearly seen. Alternatively, an optical fiber may be used instead of such a chip LED to guide light and irradiate the needle. In order to observe the positional relationship between the blood vessel image and the needle, the CCD camera itself is installed remotely, and a fiberscope 1101 having a diameter of about several mm is taken from there to the vicinity of the skin to observe these images. May be.
[0024]
FIG. 12 shows a case where the direct reflected light shielding device 301 is attached to the holder main body 1003. In addition, the fiberscope 1101 is also attached to the holder main body so that the positional relationship between the blood vessel image and the needle can be observed. The needle LED 701 for needle illumination attached to the cylinder 1004 may adjust the radiation intensity based on the appearance of the needle. After setting the holder so that the needle is positioned on the blood vessel while observing the blood vessel image in this way, blood collection was performed by the above-described procedure, and approximately 4 μl of blood could be guided onto the chip. Was.
[0025]
Next, FIG. 13 shows a case where the tip of the cylinder 1004 covering the periphery of the painless needle 901 is cut obliquely. In this case, unlike FIG. 10, there is a difference that the painless needle is not stabbed perpendicularly to the skin surface but is stabbed diagonally. Here, the cut angle was set to 45 °, the positional relationship between the blood vessel image and the needle was confirmed in the same procedure as before, the blood vessel was set at a position where the needle pierces the blood vessel, and blood was collected. As a result, about 4 μl of blood could be guided to the channel on the chip. Further, even when the needle is punctured obliquely to the skin surface in this way, the direct reflected light shielding device 301 may be attached to the holder main body 1003 as in the case of puncturing the skin vertically. In this case, the holder may be movable with respect to the direct reflection light blocking device as in the case where the syringe and the direct reflection light blocking device shown in FIG. 7 are integrated. Further, in FIG. 13, the blood vessel image and the needle may be observed with a fiber scope or the like instead of the CCD 104, and the fiber scope may be integrated with the holder body to make the apparatus compact.
[0026]
【The invention's effect】
As described above, when blood is collected by a normal injection method, the blood vessel visualization method and apparatus of the present invention are used to confirm the position of the blood vessel without using a tourniquet as in the past, and to surely use the blood collection needle. It led to blood vessels, and blood could be collected. As a result, blood can be collected without giving the blood-collected person physical pain when wearing the tourniquet. In addition, blood can be collected more reliably on a chip blood analyzer equipped with a painless needle by checking the position of the painless needle and the position of the blood vessel. Therefore, health care can be performed by each person easily collecting blood at home according to the present invention and analyzing the blood.
[Brief description of the drawings]
FIG. 1 is a diagram illustrating a blood vessel image visualization device using a light reflection method.
FIG. 2 is a diagram illustrating a state of light propagation in a body when light is projected on a human body.
FIG. 3 is a diagram illustrating an example of the direct reflection light blocking device of the present invention.
FIG. 4 is a diagram showing a state when a blood vessel image of a human is observed using the direct reflection light blocking device of the present invention.
FIG. 5 shows a side view of the direct reflection light shielding device of the present invention.
FIG. 6 is a diagram showing a state in which blood is collected by an injection method while observing a blood vessel image of a human using the direct reflection light shielding device of the present invention.
FIG. 7 is a view showing a device in which the direct reflection light shielding device of the present invention and a conventional syringe are integrated.
8 is a diagram showing a state in which blood is collected using the device shown in FIG. 7;
FIG. 9 is a view showing a chip-shaped blood analyzer. FIG. 10 is a view for explaining a procedure for introducing blood using the direct reflection light shielding device of the present invention on the chip-shaped blood analyzer shown in FIG. It is.
FIG. 11 is a diagram illustrating a state in which blood is introduced using the direct reflection light blocking device of the present invention on the chip-shaped blood analyzer shown in FIG. 9;
FIG. 12 is a diagram illustrating a state where blood is introduced using the direct reflection light blocking device of the present invention on the chip-shaped blood analyzer shown in FIG. 9;
FIG. 13 is a diagram illustrating a state in which blood is introduced using the direct reflection light blocking device of the present invention on the chip-shaped blood analyzer shown in FIG. 9;
[Explanation of symbols]
101 Human forearm 102 LED
103 Power supply 104 CCD camera 105 Monitor 106 Image of arm 201 Skin 202 Bone 203 Blood vessel 204 Direct reflected light 205 Light reflected after internal penetration 301 Direct reflected light blocking device 302 Through hole 401 Light 402 reflected without reaching below blood vessel Blood vessel Image 403 Image 501 of direct reflection light shielding device Direct light shielding area 601 Fixed band 602 Syringe 603 Injection needle 701 Chip LED
702 Syringe 703 Syringe 704 Guide rail 801 Skin surface 901 Painless needle 902 Channel 903 Sensor electrode 904 Electrode pad 1001 Slider 1002 Chip 1003 Holder body 1004 Cylinder 1005 Cylinder exhaust hose 1006 Blood sampling suction hose 1007 Sponge 1101 Fiberscope

Claims (18)

A blood vessel visualization method that includes a wavelength component of at least 600 to 1200 nm, and obtains a blood vessel image immediately below the skin in the vicinity of an irradiated area from reflected light when the human body is irradiated with light emitted from at least one light source, particularly Of the reflected light, the light directly reflected on the skin surface and enters the human body, but does not reach the blood vessels directly under the skin but is reflected and rejects the light that exits the body again. A blood vessel visualization method characterized in that a spatial distribution of the intensity of light that reaches deeper than a blood vessel immediately below, reflects, and emerges from the body again is captured by an image sensor and displayed on a display device. A direct component comprising at least one light source that emits light containing a wavelength component of at least 600 to 1200 nm, and at least part of the surface being made of a material that hardly transmits light of a wavelength emitted from the light source. A reflected light shielding device, in particular, one surface constituting the direct reflected light shielding device is brought into contact with the skin surface of a human body, and when light is emitted from a light source, most of the light reaches the skin surface. Sometimes at least part of the light directly reflected from the skin surface and the light that enters the human body but does not reach the blood vessels directly under the skin but is reflected and emitted outside the body again is in direct contact with the skin of the reflected light shielding device. Surface, or a direct-reflected light-shielding device and a space surrounded by the skin, so that it is not radiated outside the body again, while the skin surface is radiated from the light source. Te invade the human body, the reflected light shading device directly for causing emitted outside the body without the majority of the light coming emitted again outside reflected after reaching from deep vessel intercepts just below the skin. Light is guided from a light source that emits light containing a wavelength component of at least 600 to 1200 nm to a directly reflected light shielding device having at least a portion of a surface made of a material that hardly transmits light of a wavelength emitted from the light source. When one surface constituting the direct reflection light shielding device is brought into contact with the skin surface of a human body, most of the light emitted from the light source is made to reach the skin surface, and at this time, the light is directly reflected from the skin surface At least part of the light that enters the human body, but does not reach the blood vessels directly under the skin but reflects and exits the body again, at least a portion of the light-shielding device that is in direct contact with the skin, or the light-shielding device that directly reflects light It is blocked by the space surrounded by the device and the skin so that it does not radiate out of the body again, while it is radiated from the light source and invades the human body through the skin surface, and from the blood vessels just below the skin The directly reflected light shading device, characterized in that the majority of the light coming emitted again outside reflected from reach the parts are to be radiated to the outside without interrupting. 4. The direct reflection light shielding device according to claim 3, wherein an optical fiber is used to guide light from the light source directly to the reflection light shielding device. At least a part of the surface of the direct-reflection light-shielding device according to claim 2 or 3 that is in contact with the skin is covered with a material that absorbs light having a wavelength emitted from a light source. Direct light blocking device. The spatial distribution of the intensity of the light reflected and radiated out of the body is captured by an image sensor by the direct reflection light shielding device according to claim 2 or 3, and the image is displayed on a display device to obtain a subcutaneous blood vessel image. A blood vessel visualizing device, characterized in that: 7. A filter that transmits a wavelength range of light incident on the image sensor according to claim 6 and absorbs at least light on a shorter wavelength side than the wavelength range in front of a portion of the image sensor where light is incident. A blood vessel visualization device, which is disposed in a blood vessel. A filter that transmits a wavelength range of light incident on the image sensor according to claim 6 and absorbs light outside the wavelength range is disposed in front of a portion of the image sensor where light enters. Characteristic blood vessel visualization device. A blood collection method comprising: determining a puncture position of a blood collection needle integrated with a syringe while confirming a blood vessel position by the blood vessel visualization method according to claim 1, guiding the needle to a subcutaneous blood vessel, and performing blood collection. Method. A blood collection device, wherein the direct reflection light shielding device according to claim 2 or 3 and a syringe equipped with a blood collection needle are integrated. A blood collection device, wherein the syringe according to claim 10 is movable with respect to the direct reflection light blocking device when the direct reflection light blocking device is fixed. The puncturing position of the blood collection needle is determined while confirming the blood vessel position by the blood vessel visualization method according to claim 1, the needle is guided to a subcutaneous blood vessel, and the blood is collected on a blood analyzer integrated with the blood collection needle. A blood collection method characterized by guiding. 13. The blood collection method according to claim 9 or 12, wherein the blood collection needle is mainly irradiated with light to clarify the positional relationship between the blood vessel and the needle. A blood collection device comprising: the blood vessel visualization device according to claim 6; and a blood analysis device integrated with a blood collection needle as at least a component. 15. The blood collection device according to claim 14, further comprising a light source for irradiating the blood collection needle as a component. 16. The blood collection device according to claim 15, wherein a light source for irradiating the blood collection needle is integrated with a holder that supports a blood analyzer integrated with the blood collection needle. 15. The blood collection device according to claim 14, wherein the direct reflection light blocking device constituting the blood vessel visualization device is particularly integrated with a holder that supports the blood analyzer integrated with the blood collection needle. In the above-mentioned claim 14, one end of an image pickup device constituting the blood vessel visualization device or one end of an optical fiber for guiding light to the image pickup device is particularly integrated with a holder supporting a blood analyzer integrated with a blood collection needle. Characterized blood collection device.

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