JP2004203757A5 - - Google Patents

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Publication number
JP2004203757A5
JP2004203757A5 JP2002371866A JP2002371866A JP2004203757A5 JP 2004203757 A5 JP2004203757 A5 JP 2004203757A5 JP 2002371866 A JP2002371866 A JP 2002371866A JP 2002371866 A JP2002371866 A JP 2002371866A JP 2004203757 A5 JP2004203757 A5 JP 2004203757A5
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JP
Japan
Prior art keywords
milbemycin
milbemycins
purification method
base
fermentation culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002371866A
Other languages
Japanese (ja)
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JP4373080B2 (en
JP2004203757A (en
Filing date
Publication date
Application filed filed Critical
Priority claimed from JP2002371866A external-priority patent/JP4373080B2/en
Priority to JP2002371866A priority Critical patent/JP4373080B2/en
Priority to KR1020057011825A priority patent/KR101090047B1/en
Priority to PCT/JP2003/016438 priority patent/WO2004058771A1/en
Priority to AU2003296180A priority patent/AU2003296180A1/en
Priority to CN200380107520.2A priority patent/CN1732174B/en
Publication of JP2004203757A publication Critical patent/JP2004203757A/en
Publication of JP2004203757A5 publication Critical patent/JP2004203757A5/ja
Publication of JP4373080B2 publication Critical patent/JP4373080B2/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Description

【特許請求の範囲】
【請求項１】 発酵培養物由来のミルベマイシン類を塩基で洗浄することによるミルベマイシン類の精製法。
【請求項２】 発酵培養物由来のミルベマイシン類が、ミルベマイシンＡ３、ミルベマイシンＡ４、ミルベマイシンＤ、ミルベマイシンα１１又はミルベマイシンα１４から選択される物質の一つ又は二つ以上の混合物である、請求項１記載の精製法。
【請求項３】 発酵培養物由来のミルベマイシン類が、ミルベマイシンＡ３、ミルベマイシンＡ４又はこれらの混合物である、請求項１又は２記載の精製法。
【請求項４】 洗浄すること溶媒中で行う、請求項１〜３のいずれか１項記載の精製法。
【請求項５】 発酵培養物由来のミルベマイシン類の酢酸エチル溶液を塩基で洗浄する、請求項１〜４のいずれか１項記載の精製法。
【請求項６】 塩基が、アミン類の溶液である、請求項１〜５のいずれか１項記載の精製法。
【請求項７】 塩基が、アンモニア水溶液である、請求項１〜６のいずれか１項記載の精製法。
【請求項８】 さらに、再結晶化法、液−液分配法又は誘導化法を組み合わせ精製する、請求項１〜７のいずれか１項記載の精製法。 [Claims]
1. A method for purifying milbemycins by washing milbemycins derived from a fermentation culture with a base.
2. A fermentation culture milbemycins from the milbemycin A 3, milbemycin A 4, a milbemycin D, one or a mixture of two or more materials selected from milbemycin alpha 11 or milbemycin alpha 14, wherein Item 7. The purification method according to Item 1.
3. The method according to claim 1, wherein the milbemycins derived from the fermentation culture are milbemycin A 3 , milbemycin A 4 or a mixture thereof.
4. The purification method according to claim 1, wherein the washing is performed in a solvent.
5. The purification method according to claim 1, wherein the ethyl acetate solution of the milbemycins derived from the fermentation culture is washed with a base.
6. The purification method according to claim 1, wherein the base is a solution of amines.
7. The method according to claim 1, wherein the base is an aqueous ammonia solution.
8. The purification method according to claim 1, further comprising a combination of recrystallization, liquid-liquid partitioning or derivatization.

JP2002371866A 2002-12-24 2002-12-24 Purification of milbemycins Expired - Lifetime JP4373080B2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002371866A JP4373080B2 (en) 2002-12-24 2002-12-24 Purification of milbemycins
CN200380107520.2A CN1732174B (en) 2002-12-24 2003-12-22 Method for purification of milbemycins
PCT/JP2003/016438 WO2004058771A1 (en) 2002-12-24 2003-12-22 Method for purification of milbemycins
AU2003296180A AU2003296180A1 (en) 2002-12-24 2003-12-22 Method for purification of milbemycins
KR1020057011825A KR101090047B1 (en) 2002-12-24 2003-12-22 Method for purification of milbemycins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002371866A JP4373080B2 (en) 2002-12-24 2002-12-24 Purification of milbemycins

Publications (3)

Publication Number Publication Date
JP2004203757A JP2004203757A (en) 2004-07-22
JP2004203757A5 true JP2004203757A5 (en) 2006-02-16
JP4373080B2 JP4373080B2 (en) 2009-11-25

Family

ID=32677215

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002371866A Expired - Lifetime JP4373080B2 (en) 2002-12-24 2002-12-24 Purification of milbemycins

Country Status (5)

Country Link
JP (1) JP4373080B2 (en)
KR (1) KR101090047B1 (en)
CN (1) CN1732174B (en)
AU (1) AU2003296180A1 (en)
WO (1) WO2004058771A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2886640A1 (en) 2013-12-18 2015-06-24 Riga Technical University Process for isolation of milbemycins A3 and A4
CN110437248B (en) * 2017-04-19 2020-09-01 丽珠集团福州福兴医药有限公司 Production method of milbemycins capable of shortening production cycle

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582852A (en) * 1983-11-02 1986-04-15 Ciba-Geigy Corporation 14- and 15-hydroxy milbemycin derivatives for controlling plant and animal parasites
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
US4857509A (en) * 1985-01-22 1989-08-15 Ciba-Geigy Corporation 13β-alkylmilbemycin derivatives for controlling parasites of animals and plants
JPH0678342B2 (en) * 1986-01-07 1994-10-05 三共株式会社 New macrolide compound
AR243528A1 (en) * 1986-12-11 1993-08-31 Sankyo Co A procedure for preparing macrolide compounds, and a procedure producing a pesticide compound with them.
US4855317A (en) * 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
JP2849389B2 (en) * 1988-07-05 1999-01-20 三共株式会社 New macrolide compound
NZ233680A (en) * 1989-05-17 1995-02-24 Beecham Group Plc Avermectins and milbemycins and compositions thereof
NZ242592A (en) * 1991-05-13 1993-12-23 Merck & Co Inc PROCESS FOR CONVERTING 13#a# HYDROXY AVERMECTIN AGLYCONES TO THE 13#B#
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
JPH0717979A (en) * 1993-06-30 1995-01-20 Takeda Chem Ind Ltd Physiologically active substance ad-24-1b
DE69415675T2 (en) * 1993-07-23 1999-05-20 Pfizer Process for the precipitation of natural avermectins and fermentation process for the production of the same
JPH08134071A (en) * 1994-11-04 1996-05-28 Sankyo Co Ltd New 13-site-substituted milbemycin derivative
JP3499097B2 (en) * 1995-09-22 2004-02-23 三共アグロ株式会社 Insecticidal milbemycin derivatives having a substituent containing an oxime group at position 13
NO317090B1 (en) * 1995-09-29 2004-08-02 13-substituted milbemycin-5-oxime derivatives, anthelmistic, mite-killing and insecticidal preparations comprising such a compound, methods for protecting plants against parasite damage and using the compounds to prepare

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