JP2004135824A - High order brain disfunction diagnostic apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a high order brain disfunction diagnostic apparatus diagnosing the high order brain disfunction such as Alzheimer disease in an early stage where neither the memory disorder nor the memorization disturbance appears yet. <P>SOLUTION: This high order brain disfunction diagnostic apparatus 1 is provided with, at least, operation input means 11 and 12 disposed in a plurality of positions in a space and receiving an operation by a subject, an instruction means instructing to the subject to operate either one of the operation input means 11 and 12 and a reaction time measuring means measuring a reaction time, or a time difference from a time when the instruction means instructs the subject till a time when the operation input means 11 or 12 receives the operation by the subject. This apparatus can measure the reaction time under such conditions that the relative disposition of the operation input means 11 or 12 operated by the subject to the body center and the relative disposition of the body position used when the subject operates the operation input means 11 or 12 to the body center are nonconforming. <P>COPYRIGHT: (C)2004,JPO

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to an apparatus for diagnosing higher brain dysfunction represented by Alzheimer's disease.
[0002]
[Prior art]
Alzheimer's disease, one of the higher brain dysfunctions, has short-term and long-term memory deficits as basic symptoms, as well as higher cerebral cortical functions such as disability in abstract thinking and judgment, aphasia, apraxia, agnosia, and structural disorders Causes abnormalities and personality changes. In clinical practice, a so-called Hasegawa-type simple intelligence evaluation scale is often used when diagnosing the presence or absence of Alzheimer's disease. This is a simple intelligence test method created for the purpose of screening elderly people with dementia or the like (see Non-Patent Document 1). The questions on the Hasegawa-style simplified intelligence evaluation scale consist of orientation, memory, memorization, calculation, and recall, and by having the subjects answer verbally, it is possible to determine the presence or absence and approximate degree of general intelligence disorders. In addition to the screening described above, a detailed neuropsychological test, blood test, and various tests such as CT and MRI are performed, and Alzheimer's disease is diagnosed.
[0003]
In recent years, PET (positron CT) and SPECT (single photon emission CT) can be used to measure glucose metabolism, oxygen consumption rate, cerebral blood flow, and the like in the brain, which cannot be obtained by CT or MRI. Alzheimer's disease is becoming evident. For example, in young Alzheimer's disease, glucose metabolism in the parietal lobe is significantly reduced (see Non-Patent Document 2). Although these are promising means that can capture the early symptoms of Alzheimer's disease, radioactive substances need to be administered to the body of the subject, and at present, they are not widely used for research purposes.
[0004]
[Non-Patent Document 1] Kazuo Hasegawa, "Revised Hasegawa-type simple intelligence evaluation scale", [online], searched on September 9, 2002, Internet <URL http: // www. noge. or. jp / gaiyou / kango-bu / byoutou / suke-ru / hasegawa. htm>
[Non-Patent Document 2] Sakamoto S, Ishii K, Sasaki M, Hosaka K, Mori T, Matsui M, Hirono N, Mori E, "Differences in cerebral metabolic impairment between early and late onset types of Alzheimer's disease" J Neurol Sci
2002 Aug 15; 200 (1-2): 27-32.
[0005]
[Problems to be solved by the invention]
In diagnosing Alzheimer's disease, it is fundamental to investigate the presence and degree of memory impairment and memory impairment. However, in the early stages of Alzheimer's disease, they often give a vague impression that they are somewhat different from the past, such as reduced interest, reduced concentration, etc. Is not always apparent. Especially in the early stage of juvenile Alzheimer's disease, memory impairment and memory impairment are rare. For this reason, doctors, patients, and those around them often do not notice the onset of Alzheimer's disease, and the disease is diagnosed only after the disease progresses to a considerable extent.
[0006]
In view of the above problems, an object of the present invention is to enable early diagnosis of higher brain dysfunction such as Alzheimer's disease, and to provide an effective means for that purpose.
[0007]
[Means for Solving the Problems]
In order to solve the above-described problem, an operation input unit that is arranged at a plurality of positions in a space and receives an operation by a subject, an instruction unit that instructs the subject which of the operation input units is to be operated, and the instruction A higher cerebral dysfunction diagnostic device is provided, which comprises at least a reaction time measuring means for measuring a reaction time, which is a time difference from when the means executes an instruction to the subject until the operation input means receives an operation by the subject.
[0008]
Alzheimer's disease suffers from spatial cognitive abilities and other brain functions, even though memory and memory deficits are not yet apparent. Then, for example, the ability to operate an object existing on the left side with respect to the affected patient using his / her right hand is reduced. According to the present invention, the relative arrangement with respect to the center of the body of the operation input means operated by the subject and the body center used when the subject operates the operation input means are incompatible with each other. By measuring the reaction time under the condition of `` center coordinate system mismatch '', it is possible to detect the loss of brain function and diagnose whether the subject is suffering from higher brain dysfunction .
[0009]
Alternatively, operation input means arranged at a plurality of positions in the space to receive an operation by the subject, instruction means for instructing the subject on which of the operation input means to operate, and an operation input receiving the operation by the subject Means for determining whether or not the instructing means has instructed the subject as an operation to be performed. By examining the correct answer rate or the incorrect answer rate below, it may be possible to diagnose the presence or absence of higher brain dysfunction.
[0010]
In addition, the instruction means outputs a stimulus in a form appealing to the subject's five senses at any of a plurality of positions in the space, and indicates the operation input means to be operated by the subject according to the output position. The correlation between the output position of the subject and the operation input means to be operated by the subject can be changed, and the relative arrangement of the operation input means operated by the subject with respect to the body center and the effect that the operation input means should be operated are described. It is preferable to be able to measure the response time under conditions where the relative position of the output position of the indicated stimulus with respect to the body center is compatible and incompatible, or to investigate the correct or incorrect rate. With such a configuration, it is possible to more clearly detect the wear of the function for coping with the incompatibility of the subject's body center coordinate system.
[0011]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, embodiments of the present invention will be described with reference to the drawings. As shown in FIG. 1, a higher cerebral dysfunction diagnostic device 1 according to the present embodiment includes operation input units 11 and 12 that are arranged at a plurality of positions in a space and receive an operation by a subject. An instructing means 13 for instructing the subject on which of them should be operated, and a reaction which is a time difference from when the instructing means 13 executes an instruction to the subject until the operation input means 11, 12 receives an operation by the subject. It comprises a reaction time measuring means 14 for measuring time, and a judging means 15 for judging whether or not the operation input means 11 and 12 which have received the operation by the subject are instructed to be operated. The subject operates the operation input units 11 and 12 to be operated based on the instruction from the instruction unit 13. Then, the reaction time is measured by the reaction time measuring means 14 and the correct answer rate or the incorrect answer rate is investigated by using the function of the judging means 15.
[0012]
Patients with higher brain dysfunction represented by Alzheimer's disease exhibit various symptoms, one of which is a decrease in the ability to cope with a state in which the body center coordinate system is incompatible. Here, it is described that the body center coordinate system conforms or the body center coordinate system does not conform.Based on the subject's body center or body axis, the extracorporeal space and the subject's body are divided into a plurality of space divisions and body parts. In the case, the element to be compared is in the corresponding section, that is, the space section to which one of the operation input means 11 and 12 arranged in the space belongs and the body used when operating the operation input means 11 and 12 Correspondence between the parts is called body center coordinate system adaptation, and incompatibility is called body center coordinate system incompatibility. As a typical example, when the extracorporeal space is viewed from the subject, it is divided into left and right space, left space and right space, and when the subject's body is divided into left half and right half, the operation existing in the left space Operating the input means 11 using the required part of the left body corresponds to body center coordinate system adaptation, and operating the input means 11 using the required part of the right body corresponds to body center coordinate system mismatch. By measuring the reaction time and / or examining the correct answer rate or incorrect answer rate using the higher brain dysfunction diagnostic apparatus 1 according to the present invention, the ability to cope with the state of incompatibility with the body center coordinate system can be quantitatively determined. It is possible to evaluate and, in turn, to diagnose the presence or absence of higher brain dysfunction.
[0013]
The higher cerebral dysfunction diagnosis device 1 includes, for example, hardware resources such as a processor 1a, a main memory 1b, an auxiliary storage device 1c, a display control device 1d, a display 1e, and an input device 1f, as shown in FIG. I do. The auxiliary storage device 1c is a hard disk drive, a flash memory, an optical disk drive such as a DVD-ROM, or the like, but may be a detachable one, that is, a cartridge type memory card, an external type disk drive, or the like. . The display control device 1d generates a video chip (or graphics chip) 1d1 having a function of generating image data to be displayed based on a drawing instruction received from the processor 1a and transmitting the generated image data to the display 1e, an image data and the like. It can be configured using a known device such as a video memory (Video RAM) 1d2 that plays a role of temporarily storing. The input device 1f generally includes a push button, a keyboard, a mouse, a trackpad, a touch panel, and the like that can be operated by the fingers of the subject.
[0014]
Usually, a program to be executed by the processor 1a is stored in the auxiliary storage device 1c. When the program is executed, the program is read from the auxiliary storage device 1c into the main memory 1b and decoded by the processor 1a. Then, the above-mentioned hardware resources are operated according to the program, so that the functions as the operation input means 11 and 12, the instruction means 13, the reaction time measurement means 14 and the determination means 15 shown in FIG.
[0015]
As described above, the operation input means 11 and 12 receive an operation by a subject. The operation input means 11 and 12 are configured using the input device 1f and its device driver. As shown in FIGS. 4A and 4B, two operation input means 11 and 12 are arranged at left and right positions in the space, one of which is operated by the subject's left hand (or right hand), and the other is operated. Is preferably operated by the right hand (left hand). In this embodiment, the operation input means 11 and 12 are arranged by pressing two push buttons and the like which can be operated with the fingers of the subject on the left and right sides from the front of the median of the subject. However, various forms of the operation input means 11 and 12 are conceivable. For example, the operation input means 11 and 12 are provided with two separated keys ("z" key and "/" key, etc.) on a general-purpose keyboard. It may be set to 12.
[0016]
The instruction means 13 instructs the operation input means 11 and 12 to be operated by the subject in a manner appealing to the subject's five senses. In the present embodiment, a stimulus in a manner that appeals to the subject's five senses, particularly to the visual sense, is output at any one of a plurality of positions L1 and L2 in the space, and the output position instructs operation input means 11 and 12 to be operated. And In the present embodiment, the instruction unit 13 is configured using the functions of the display control device 1d and the display 1e. Then, as shown in FIGS. 5 (a) and 5 (b), a sign SN to be stimulated is displayed at one of left and right predetermined positions L1 and L2 on the screen 1e1 of the display 1e, so that either left or right operation input is performed. An instruction to operate the means 11 and 12 is given to the subject. The display of the sign SN at the left position L1 on the screen 1e1 may indicate that the operation input unit 11 on the left side should be operated when viewed from the subject, or the right side when viewed from the subject. The operation input means 12 may be instructed to be operated. This will be described later.
[0017]
The reaction time measuring unit 14 measures a reaction time, which is a time difference from when the instruction unit 13 executes an instruction to the subject to when the operation input units 11 and 12 accept the operation by the subject. Data relating to the measured reaction time is stored in a required storage area of the main memory 1b or the auxiliary storage device 1c.
[0018]
The judging means 15 judges whether or not the operation input means 11 and 12 which have received the operation by the subject are what the instructing means 13 has instructed the subject to perform. Data relating to the determination result is stored in a required storage area of the main memory 1b or the auxiliary storage device 1c.
[0019]
Incidentally, the functions of the above-described units are shared by a plurality of information processing devices communicably connected via an electric communication line, and are realized as a higher cerebral dysfunction diagnosis device 1 by cooperating with each other. Is also good.
[0020]
As shown in FIG. 4, the operation input means 11 arranged on the left side is operated with the left hand of the subject, and the operation input means 12 arranged on the right side of the subject is And the operation input means 11 arranged on the left side is operated by the right hand of the subject, and the operation input means 12 arranged on the right side is operated by the left hand of the subject. The test is performed on the subject under the condition of the body center coordinate system mismatch (shown in FIG. 4B).
[0021]
In addition, in order to more accurately evaluate the ability to cope with the state of incompatibility with the body center coordinate system, the relative arrangement of the operation input means 11 and 12 operated by the subject with respect to the body center and the stimulus output by the instruction means 13 are described. It is desirable to measure the reaction time under conditions where the relative positions of the output positions L1 and L2 with respect to the body center are compatible and incompatible, or to investigate the correct answer rate or the incorrect answer rate. More specifically, based on the body center or body axis of the subject, a region of the extracorporeal space in which the stimulus is output by the instruction means 13 (so-called stimulation space) and the extracorporeal space in which the operation input means 11 and 12 are arranged and the subject operates. Is divided into a plurality of space sections, the element to be compared is in the corresponding section, that is, the space section to which the stimulus output positions L1 and L2 in the stimulus space belong and the reaction The correspondence here corresponds to the space section to which one of the operation input means 11 and 12 arranged in the space belongs, and the non-compliance here means that they do not correspond. In particular, in the present embodiment, the sign SN that is a stimulus in a form that appeals to the subject's vision via the display 1e is output on the screen 1e1 that is a stimulus space. The above “mismatch” can be referred to as “retinal center coordinate system mismatch”. As a typical example, as shown in FIG. 5, when the stimulus space and the reaction space are each divided into left and right space divisions as viewed from the subject, the stimulus is output in the left (right) division of the stimulus space. On the other hand, causing the subject to operate the operation input means 11 and 12 existing in the left (right) section of the reaction space corresponds to the retinal center coordinate system adaptation (shown in FIG. 5A), and the right (left) of the reaction space. The operation of the operation input means 11 and 12 existing in the section (1) by the subject corresponds to the retinal center coordinate system mismatch (shown in FIG. 5B). If the condition of conformity / non-conformity of the body center coordinate system is further matched with the condition of conformity / non-conformity of the retinal center coordinate system, 2 × 2 = 4 test conditions are generated. Under these conditions, an instruction is given to the subject by the instruction means 13 and an attempt is made to operate the operation input means 11, 12 to be operated based on the instruction, the reaction time is measured, and the correct answer rate or incorrect answer is measured. Investigate rates. Usually, the trial is performed a plurality of times under each condition.
[0022]
Further, it is preferable that the instruction means 13 can change the correlation between the stimulus output positions L1 and L2 and the operation input means 11 and 12 to be operated by the subject at random or according to a preset pattern. In other words, it is preferable that the condition of conformity / non-conformity of the retinal center coordinate system can be changed at random or for each trial according to a preset pattern. At this time, if the instruction means 13 teaches the correlation between the stimulus output positions L1 and L2 and the operation input means 11 and 12 to be operated by the subject prior to the output of the stimulus which is an instruction to the subject, More preferred. For example, as shown in FIG. 6, a display T1 (shown in FIG. 6A) or a retinal center coordinate system for instructing the subject that the next and subsequent trials are performed under the conditions of the retinal center coordinate system adaptation. The indication means 13 is configured to appropriately output a display T2 (shown in FIG. 6B) for instructing the subject to be performed under the non-conforming condition on the screen 1e1.
[0023]
The procedure of the process executed by the higher brain dysfunction diagnostic device 1 in the present embodiment will be described with reference to the flowchart of FIG. First, it is determined at random or according to a preset pattern whether the next and subsequent trials are performed under the condition of conformity with the retinal central coordinate system or under the condition of non-conformity of the retinal central coordinate system (step S1). The instruction means 13 outputs the conditions of conformity / non-conformity of the retinal center coordinate system determined in step S1 (displaying the display T1, T2 illustrated in FIG. 6A or FIG. 6B on the screen 1e1). Instruct the subject (step S2). Then, the instruction means 13 selects any one of the positions L1 and L2 on the screen 1e1 as the stimulus space (Step S3) and outputs the stimulus signature SN (Step S4). Subsequently, each of the operation input units 11 and 12 waits for an operation input by the subject (step S6), and the reaction time measurement unit 14 measures the elapsed time until one of the operation input units 11 and 12 receives the operation. Is started (step S5). When one of the operation input units 11 and 12 receives an operation (step S6), the measurement of the elapsed time by the reaction time measurement unit 14 is completed (step S7). The determining means 15 determines whether or not the subject has operated the correct operation input means 11 and 12 that match the instruction from the instruction means 13 (step S8). At this time, it is determined whether or not the operation input means 11 and 12 that have received the operation have instructed that the operation should be performed, based on the conditions for conformity / non-conformity of the retinal center coordinate system determined in step S1. To give a specific example, when the operation input means 11 on the left side as viewed from the subject is operated when the sign SN is output at the left position L1 on the screen 1e1, under the condition of conformity with the retinal center coordinate system, The answer is determined to be correct, and is determined to be incorrect under conditions where the retinal center coordinate system is incompatible. The steps S1 to S8 or the steps S3 to S8 are repeated as necessary. The measurement data of the reaction time obtained by the trial or the data of the judgment result of the correct answer / wrong answer is transmitted to an external information processing device via a telecommunication line, displayed on the screen 1e1 of the display 1e, and hard disk, flexible disk, or the like. The data is output in a form such as writing to a storage medium, printing out, and the like.
[0024]
Hereinafter, results of a test performed using the higher brain dysfunction diagnostic device 1 according to the present invention will be described. FIG. 8 shows the measurement results of the reaction times of healthy persons (20 persons, average age 23.5 years) not suffering from Alzheimer's disease. UU is suitable for the body center coordinate system and the retinal center coordinate system, uI is suitable for the body center coordinate system and the retinal center coordinate system is not suitable, cC is not suitable for the body center coordinate system and the retinal center coordinate system is suitable, and cI is the body center coordinate system. It shows the reaction time in the trial under the conditions of non-conformity / fitness to the central retinal coordinate system. As shown in FIG. 9, the reaction time under the condition that the body center coordinate system is not suitable tends to be later than the reaction time under the condition that the body center coordinate system is suitable. However, there is no significant difference between the reaction time under uI conditions and the reaction time under cC conditions. On the other hand, what is shown in FIG. 9 is the measurement result of the reaction time of the early-stage juvenile Alzheimer's disease sufferer (50's). As a general tendency, the reaction time is delayed (the reaction time is also affected by aging and the like), but is apparent even when the reaction time under the uI condition and the reaction time under the cC condition are compared. As described above, the delay of the reaction time becomes remarkable especially under the condition that the body center coordinate system is incompatible. Further, the correct answer rate of this subject was as shown in FIG. The correct answer rate under the condition that the body center coordinate system is incompatible is clearly reduced. In addition, when a healthy person is used as a subject, a large change in the correct answer rate depending on the test condition is not observed.
[0025]
In the test, the subject integrates the visual information input from the outside with the information on the body position and posture in the space of his / her body part input via the proprioceptive, It is necessary to perform spatial coding for performing the operation (ie, operating the operation input means 11, 12). At this time, especially the frontal-parietal and superior temporal gyrus (STG) of the brain are functioning. However, if the frontal-parietal or superior temporal gyrus is damaged due to Alzheimer's disease or the like, spatial coding ability is reduced, and as a result, it is difficult to cope with a state in which the body center coordinate system is incompatible. The present invention has been made with a focus on this point, and the presence or absence of a higher cerebral dysfunction such as Alzheimer's disease can be determined at an early stage by quantitatively evaluating the test subject's ability to cope with a state of incompatibility with the body center coordinate system. It is possible to make a diagnosis.
[0026]
According to the present embodiment described in detail above, the operation input means 11 and 12 which are arranged at a plurality of positions in the space and receive an operation by the subject, and which of the operation input means 11 and 12 is to be operated, Instruction means 13 for instructing a subject, and a reaction time measuring means 14 for measuring a reaction time which is a time difference between when the instruction means 13 executes an instruction to the subject and when the operation input means 11 and 12 accept an operation by the subject. And the relative arrangement of the operation input means 11 and 12 operated by the subject with respect to the body center and the relative arrangement of the body part used when the subject operates the operation input means 11 and 12 with respect to the body center By using the higher cerebral dysfunction diagnosis device 1 configured to be able to measure the reaction time under the condition of the body center coordinate system incongruity with The ability to cope state of the central coordinate system incompatibility can be quantitatively evaluated, even sufferers characteristic symptoms is not always pronounced initial higher brain dysfunction is possible diagnose the diseased. The higher cerebral dysfunction diagnostic device 1 can be used at low cost because it does not require expensive test equipment or special chemicals. In addition, it is non-invasive and has a light mental and physical burden on the subject, and has very little risk of side effects even if the diagnosis is performed periodically.
[0027]
Similarly, operation input means 11 and 12 arranged at a plurality of positions in the space to receive an operation by the subject, instruction means 13 for instructing the subject which of the operation input means 11 and 12 should be operated, The operation input means 11 and 12 having received the operation by the subject are provided with a determination means 15 for determining whether or not the instruction means 13 has instructed the subject as an operation to be performed. Correct answer under the condition that the relative arrangement of the input means 11 and 12 with respect to the body center and the relative arrangement of the body part used when the subject operates the operation input means 11 and 12 with respect to the body center are incompatible. By using the higher cerebral dysfunction diagnosis device 1 configured to be able to investigate the rate or wrong answer rate, it is possible to quantitatively evaluate the ability to cope with a state in which the body center coordinate system is incompatible, Early diagnosis of the following brain dysfunction is possible.
[0028]
Further, the instructing means 13 outputs a stimulus SN in a mode of appealing to the subject's five senses at one of a plurality of positions L1 and L2 in the space, and the operation input means 11 to be operated by the subject according to the output positions L1 and L2. 12, if the correlation between the output positions L1, L2 of the stimulus SN and the operation input means 11, 12 to be operated by the subject can be changed, the operation input means 11, operated by the subject, Conditions in which the relative arrangement of the stimulus SN indicating that the operation input means 11 and 12 should be operated and the relative arrangement of the output positions L1 and L2 of the stimulus SN relative to the body center with respect to the body center are compatible and incompatible. Can be measured, or the rate of correct or incorrect answers can be investigated. That is, the reaction time under the conditions of uI (inappropriate body center coordinate system / conformity in retinal center coordinate system) and cI (inappropriate body center coordinate system / inappropriate retinal coordinate system) in the above example can be measured, or the correct answer rate Or you can investigate the wrong answer rate. Then, it becomes possible to more accurately detect the wear of the function for coping with the state of the subject's incompatibility with the body center coordinate system, which contributes to early diagnosis of higher brain dysfunction.
[0029]
Note that the present invention is not limited to the embodiment described in detail above. In particular, the stimulus by the instruction unit 13 is not limited to the one that appeals to the visual sense of displaying the sign SN on the screen 1e1 of the display 1e, and may be, for example, one that appeals to the sense of hearing or touch.
[0030]
In addition, the specific configuration of each unit, the procedure of the process shown in FIG. 7, and the like are not limited to the above embodiment, and various modifications can be made without departing from the spirit of the present invention. Of course, it is also possible to configure the higher brain dysfunction diagnosis device 1 according to the present invention by installing a program in a personal computer or other general-purpose information processing device, and it is essential to manufacture a dedicated device. Not necessarily.
[0031]
【The invention's effect】
According to the present invention described in detail above, higher brain dysfunction such as Alzheimer's disease can be diagnosed at an early stage.
[Brief description of the drawings]
FIG. 1 is a diagram showing an entire configuration of a higher brain dysfunction diagnosis apparatus according to an embodiment of the present invention.
FIG. 2 is a diagram showing hardware resources included in the higher brain dysfunction diagnosis apparatus.
FIG. 3 is a functional block diagram of the higher brain dysfunction diagnosis apparatus.
FIG. 4 is a view schematically showing a test method using the higher brain dysfunction diagnosis apparatus.
FIG. 5 is a diagram schematically showing a test method using the higher brain dysfunction diagnostic device.
FIG. 6 is a diagram illustrating an embodiment of teaching of test conditions.
FIG. 7 is a flowchart showing a procedure of processing executed by the higher brain dysfunction diagnosis device.
FIG. 8 is a view showing a result of measuring a reaction time of a healthy person.
FIG. 9 is a graph showing the results of measuring the reaction time of Alzheimer's disease patients.
FIG. 10 is a diagram showing the results of a survey on the correct answer rate of Alzheimer's disease patients.
[Explanation of symbols]
1. Higher brain dysfunction diagnostic device
11, 12 ... operation input means
13 Instruction means
14 ... Reaction time measuring means
15. Judging means

Claims (6)

Operation input means arranged at a plurality of positions in the space to receive an operation by a subject;
Instruction means for instructing the subject which of the operation input means to operate,
At least a reaction time measuring unit that measures a reaction time that is a time difference from when the instruction unit executes an instruction to the subject until the operation input unit receives an operation by the subject,
Reaction time under conditions where the relative arrangement of the operation input means operated by the subject with respect to the body center and the relative arrangement of the body part used when the subject operates the operation input means with respect to the body center are incompatible. A higher-order brain dysfunction diagnostic device configured to be able to measure the blood pressure. Operation input means arranged at a plurality of positions in the space to receive an operation by a subject;
Instruction means for instructing the subject which of the operation input means to operate,
The operation input unit that has received the operation by the subject, at least comprises a determination unit that determines whether or not the instruction unit has instructed the subject as an operation to be performed,
Correct answer rate under the condition that the relative arrangement of the operation input means operated by the subject with respect to the body center and the relative arrangement of the body part used when the subject operates the operation input means with respect to the body center are incompatible. Alternatively, a higher brain dysfunction diagnostic device configured to investigate a wrong answer rate. The instruction means outputs a stimulus in a manner appealing to the senses of the subject at any of a plurality of positions in the space, and indicates the operation input means to be operated by the subject according to the output position, and the output position of the stimulus And the correlation between the operation input means to be operated by the subject and
Under the condition that the relative arrangement of the operation input means operated by the subject with respect to the body center and the relative arrangement of the stimulus output position indicating that the operation input means should be operated with respect to the body center are compatible and incompatible. 3. The apparatus for diagnosing higher brain dysfunction according to claim 1, wherein the reaction time can be measured or the correct answer rate or incorrect answer rate can be investigated. An operation input unit that is used to configure the higher brain dysfunction diagnosis device according to claim 1, wherein the information processing device is disposed at least at a plurality of positions in a space and receives an operation by a subject.
Instruction means for instructing the subject which of the operation input means to operate, and
A program functioning as reaction time measuring means for measuring a reaction time, which is a time difference from when the instruction means executes an instruction to a subject until the operation input means receives an operation by the subject. An operation input unit that is used to configure the higher cerebral dysfunction diagnosis device according to claim 2, wherein the information processing device is arranged at least at a plurality of positions in a space and receives an operation by a subject.
Instruction means for instructing the subject on which of the operation input means to operate, and whether the operation input means that has accepted the operation by the subject is what the instruction means has instructed the subject to operate. A program that functions as a determination unit for determining whether or not the determination is made. The instruction means outputs a stimulus in a form appealing to the senses of the subject at any of a plurality of positions in the space, and indicates the operation input means to be operated by the subject according to the output position, and the output position of the stimulus 6. The program according to claim 4, wherein a correlation between the operation input means to be operated by the subject and the operation input means can be changed.

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