JP2004129518A - Feedstuff additive and feedstuff - Google Patents
Feedstuff additive and feedstuff Download PDFInfo
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- JP2004129518A JP2004129518A JP2002295252A JP2002295252A JP2004129518A JP 2004129518 A JP2004129518 A JP 2004129518A JP 2002295252 A JP2002295252 A JP 2002295252A JP 2002295252 A JP2002295252 A JP 2002295252A JP 2004129518 A JP2004129518 A JP 2004129518A
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- mcg
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- glucan
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
Description
【０００１】
【発明の属する技術分野】
本発明は、甘草（Ｇｌｙｃｙｒｒｈｉｚａ Ｒａｄｉｘ ）の粉末とβ−グルカンの粉末とからなる家畜飼料用添加物及び該添加物を添加した家畜用飼料に関するものである。
【０００２】
【従来の技術】
周知の通り、家畜の生産性はウィルスや細菌による感染症により著しく低下するので、畜産業界では、生産効率を高め、生産コストを削減できる抗病性の高い家畜を飼育するために多大のコストをかけて感染対策に取り組んでおり、ウィルスや細菌に対するワクチンが多数開発されて実用化されたことにより、法定伝染病やこれに類する感染症による被害は激減した。
【０００３】
そして、今日では、免疫低下の状況下において惹起される日和見感染が生産障害として問題視されており、この感染メカニズムは、多種の病原因子が複雑に関係して未だ十分に解明されておらず、しかも、数種の微生物が関与する複合感染のため、特異性の高いワクチンでの対応には多大の労力とコストが要求されることから、この複合感染を簡単な方法で予防することができる対策が要望されている。
【０００４】
一方、医薬に使われる東北甘草や西北甘草にはグリチルリチンが含まれており、日本薬局方によれば、この成分がインターフェロンγの産生を促進させ、抗ウィルス活性を増強させるとされており、さらに、インターロイキン２の産生にも関与し、感染源に対して非特異、特異的な防御活性を促進させることが知られている。また、β−グルカンは、免疫担当細胞であるマクロファージの膜表面レセプターに親和性があり、吸着してこの細胞の持つ非特異免疫をより強く活性化することが知られている。
【０００５】
従来、甘草抽出物であるグリチルリチンを補助成分として用いた家畜・家禽等用の抗病性飼料および飼料用添加物は公知であり（例えば、特許文献１参照）、また、β−１，３−グルカンを用いた家畜用飼料添加剤も公知である（例えば、特許文献２参照）。
【０００６】
【特許文献１】
特公平６−５５１０７号公報（第３頁）
【特許文献２】
特開平７−５０９９９号公報（第２頁）
【０００７】
【発明が解決しようとする課題】
本発明者等は、グリチルリチンを含有する甘草（例えば、東北甘草や西北甘草）とβ−グルカンとを添加した飼料を家畜に与えて発育状態及び感染状況を多数観察した結果、前記甘草とβ−グルカンとを併用することにより、単独使用では得られない相乗効果が得られてより安全で高い有効性を奏し、抗病性の高い家畜に飼育することができるという刮目すべき新知見を得て本発明を完成したものである。
【０００８】
【課題を解決するための手段】
前記技術的課題は、次の通りの本発明によって解決できる。
【０００９】
即ち、本発明に係る家畜飼料用添加物は、甘草の粉末とβ−グルカンの粉末とが配合されているものである。
【００１０】
また、本発明は、前記家畜飼料用添加物において、甘草の粉末５０ｍｃｇ 〜５００ｍｃｇに対してβ−グルカンの粉末を１００ｍｃｇ〜５００ｍｃｇとしたものである。
【００１１】
また、本発明に係る家畜用飼料は、甘草の粉末とβ−グルカンの粉末とからなる家畜飼料用添加物が添加されているものである。
【００１２】
さらに、本発明は、前記家畜用飼料において、甘草の粉末を基飼料１ｇ に対して５０ｍｃｇ 〜５００ｍｃｇ添加し、β−グルカンの粉末を基飼料１ｇ に対して１００ｍｃｇ〜５００ｍｃｇ添加したものである。
【００１３】
【発明の実施の形態】
以下、本発明の実施の形態について説明する。
【００１４】
実施の形態１．
【００１５】
本実施の形態に係る家畜飼料用添加物は、甘草の粉末（グリチルリチン含有量３〜５％）とβ−グルカンの粉末とを配合してなるものである。
【００１６】
前記甘草の粉末とβ−グルカンの粉末との配合割合は甘草の粉末５０ｍｃｇ 〜５００ｍｃｇに対してβ−グルカンの粉末を１００ｍｃｇ〜５００ｍｃｇとするのが好ましい。甘草の粉末割合が５０ｍｃｇ 未満では有効性が減となり、５００ｍｃｇを越えれば免疫系への刺激が強くなり、免疫寛容が懸念され、また安全性も懸念されるので、好ましくない。また、β−グルカンの粉末割合が１００ｍｃｇ未満では有効性が減となり、５００ｍｃｇを越えれば免疫系への刺激が強くなり、免疫寛容が懸念され、また安全性も懸念されるので、好ましくない。より好ましいのは甘草の粉末５０ｍｃｇ 〜２００ｍｃｇに対してβ−グルカンの粉末を１００ｍｃｇ〜２００ｍｃｇである。
【００１７】
甘草としては、西北甘草（Ｇｌｙｃｙｒｒｈｉｚａ ｇｌａｂｒａ）又は東北甘草（Ｇｌｙｃｙｒｒｈｉｚａ ｕｒａｌｅｎｓｉｓ ）を使用するのが好ましい。
【００１８】
本実施の形態に係る家畜飼料用添加物を家畜の基飼料に添加して家畜に与えれば、抗病性の高い家畜を飼育することができる。
【００１９】
実施の形態２．
【００２０】
本実施の形態に係る家畜用飼料は、前記実施の形態１における家畜飼料用添加物を家畜の基飼料に添加したものである。
【００２１】
甘草の粉末（グリチルリチン含有量３〜５％）の添加量は基飼料１ｇ に対して５０ｍｃｇ 〜５００ｍｃｇ、より好ましくは５０ｍｃｇ 〜２００ｍｃｇとすればよく、β−グルカンの粉末の添加量は基飼料１ｇ に対して１００ｍｃｇ〜５００ｍｃｇ、より好ましくは１００ｍｃｇ〜２００ｍｃｇとすればよい。
【００２２】
本実施の形態に係る家畜用飼料を家畜に与えれば、抗病性の高い家畜を飼育することができる。
【００２３】
【実施例】
実施例１〜７，比較例１〜５．
【００２４】
本実施例，比較例として試験を実施した農場の子豚では、４０日齢より豚インフルエンザウィルスに対する抗体が上昇し、７０日齢で全頭において抗体陽性となり、移行抗体が切れた時点よりインフルエンザＨ３Ｎ２の感染を受けることが確認されている。ここの子豚５頭を一つの群とした１１群（実施例１〜７，比較例１〜４）と子豚９頭を一つの群とした１群（比較例５）との１２群に子豚をグループ分けした。
【００２５】
各豚群において、２５日齢の各豚の体重を測定した後、基飼料１ｇ に対して表１（実施例１〜７）及び表２（比較例１〜５）に示す量のβ−グルカン粉末（マクロガード：商品名：ＢＩＯ ＴＥＣ 株式会社・製）と東北甘草粉末（小城製薬株式会社・製：グリチルリチン含有量３〜５％）とからなる家畜飼料用添加物を添加した家畜用飼料を各豚群毎に子豚２５日齢より５０日齢までそれぞれ給餌し、５０日齢における各豚の体重を測定した。そして、７０日齢において採血してインフルエンザＨ３Ｎ２ウィルスに対する抗体を測定した（血清抗体検査）。結果を表１，表２と各豚群の各平均値を表した表３に示す。
【００２６】
【表１】
【表２】
【表３】
なお、インフルエンザＨ３Ｎ２に対する血清抗体検査は、ＥＬＩＳＡ 法を準用し、ウィルス抗原をＥＬＩＳＡ 用マイクロプレートに吸着させて固定化した後、供試血清を１次抗体、ＰＯＤ 標識抗豚ＩｇＧ 抗体を２次抗体として反応させ、酵素抗体法で発色させて判定した。目視により発色の度合いを判別して準定量的に抗体価を−（陰性）、±（擬陽性）、＋（弱陽性）、＋２（強陽性）とした。ＥＬＩＳＡ 抗体が低い価である場合、検出されない場合は豚体内でウィルスが増殖していないことを現している。
【００３０】
安全性は２５日齢と５０日齢との体重差により判断し、有効性は前記抗体価で判断した。
【００３１】
表３より、比較例１〜４の単独添加及び比較例５の無添加に比べて、東北甘草粉末を５０ｍｃｇ 〜５００ｍｃｇ及びβ−グルカン粉末を１００ｍｃｇ〜５００ｍｃｇ配合した家畜飼料用添加物の添加が安全性と有効性とにおいて総合的に好ましい結果が得られたことが確認でき、さらに、東北甘草粉末５０ｍｃｇ 〜２００ｍｃｇとβ−グルカン粉末１００ｍｃｇ〜２００ｍｃｇとの家畜飼料用添加物において最も好ましい結果が得られたことが確認できる。
【００３２】
実施例８〜１４，比較例６〜１０．
【００３３】
採卵鶏雛（イサブラウン）３０〜５０日齢の間に鶏伝染性喉頭気管支炎ウィルス（ＩＢＶ ）Ｍ株，Ｙ株の感染が認められ、全群において抗体価の上昇が確認されている養鶏場にて、鶏雛１０羽を一つの群とした１１群（実施例８〜１４，比較例６〜９）と鶏雛２０羽を一つの群とした１群（比較例１０）との１２群に鶏雛をグループ分けした。
【００３４】
各鶏群において、基飼料１ｇ に対して表４（実施例８〜１４及び比較例６〜１０）に示す量のβ−グルカン粉末（マクロガード：商品名：ＢＩＯ ＴＥＣ 株式会社・製）と東北甘草粉末（小城製薬株式会社・製：グリチルリチン含有量３〜５％）とからなる家畜飼料用添加物を添加した家畜用飼料を各鶏群毎に鶏雛２０日齢より５０日齢までそれぞれ給餌し、６０日齢で採血してＩＢＶ に対する抗体を測定した。結果を表４に示す。
【００３５】
【表４】
なお、ＩＢＶ に対する抗体測定は、ＩＢＶ ＥＬＩＳＡ キット（株式会社ゲンコーポレーション・販売）を使用し、準用した。ＩＢＶ に対する抗体はＥＬＩＳＡ で測定したが、２波長法で測定した吸光度での値は０．２ 以下が陰性（−）、０．２１〜１．０ が陽性（＋）、１．０ 以上が強陽性（＋２）と判定される。安全性は産卵成績により判断し、有効性は抗体価で判断した。
【００３７】
表４より、比較例６〜９の単独添加及び比較例１０の無添加に比べて、東北甘草粉末を５０ｍｃｇ 〜５００ｍｃｇ及びβ−グルカン粉末を１００ｍｃｇ〜５００ｍｃｇ配合した家畜飼料用添加物の添加が有効性において好ましい結果が得られたことが確認でき、さらに、東北甘草粉末５０ｍｃｇ 〜２００ｍｃｇとβ−グルカン粉末１００ｍｃｇ〜２００ｍｃｇとの家畜飼料用添加物において顕著な差異が見られ、最も好ましい結果が得られたことが確認できる。なお、産卵成績による差異は無かった。即ち、安全性に問題はなかった。
【００３８】
【発明の効果】
本発明によれば、より安全で高い有効性を奏し、抗病性の高い家畜を飼育することができる家畜飼料用添加物及び該添加物を添加してなる家畜用飼料を提供することができる。
【００３９】
従って、本発明の産業上利用性は非常に高いといえる。[0001]
TECHNICAL FIELD OF THE INVENTION
TECHNICAL FIELD The present invention relates to a livestock feed additive comprising a powder of licorice (Glycyrrhiza Radix) and a powder of β-glucan, and a livestock feed to which the additive is added.
[0002]
[Prior art]
As is well known, livestock productivity is significantly reduced due to viral and bacterial infections, and the livestock industry is spending a significant amount of money on raising highly disease-resistant livestock that can increase production efficiency and reduce production costs. With the development and commercialization of numerous vaccines against viruses and bacteria, the damage caused by statutory infectious diseases and similar infectious diseases has been drastically reduced.
[0003]
Nowadays, opportunistic infections caused by immunocompromised conditions are regarded as production disorders, and the mechanism of this infection has not yet been fully elucidated due to the complex involvement of various pathogenic factors. Moreover, since complex infections involving several types of microorganisms require a great deal of labor and cost to respond with highly specific vaccines, measures that can prevent this complex infection in a simple manner Is required.
[0004]
On the other hand, glycyrrhizin is contained in Tohoku licorice and Northeast licorice used in medicine, and according to the Japanese Pharmacopoeia, this component promotes the production of interferon γ and enhances antiviral activity. It is also known to be involved in the production of interleukin 2 and to promote non-specific and specific protective activity against the source of infection. It is known that β-glucan has an affinity for the membrane surface receptor of macrophages, which are immunocompetent cells, and adsorbs and activates the nonspecific immunity of the cells more strongly.
[0005]
BACKGROUND ART Conventionally, anti-disease feeds and feed additives for livestock and poultry using glycyrrhizin, which is a licorice extract, as an auxiliary component are known (for example, see Patent Document 1). Livestock feed additives using glucan are also known (for example, see Patent Document 2).
[0006]
[Patent Document 1]
Japanese Patent Publication No. 6-55107 (page 3)
[Patent Document 2]
JP-A-7-50999 (page 2)
[0007]
[Problems to be solved by the invention]
The present inventors have given livestock a feed containing glycyrrhizin-containing licorice (eg, Tohoku licorice or Northeast licorice) and β-glucan, and observed a large number of growth states and infection states. By using together with glucan, a synergistic effect that cannot be obtained by single use is obtained, more safe and high efficacy is achieved, and it is possible to breed in livestock with high disease resistance. The present invention has been completed.
[0008]
[Means for Solving the Problems]
The technical problem can be solved by the present invention as described below.
[0009]
That is, the additive for livestock feed according to the present invention is a mixture of licorice powder and β-glucan powder.
[0010]
Further, the present invention provides the additive for livestock feed, wherein the powder of β-glucan is 100 mcg to 500 mcg with respect to the powder of licorice 50 mcg to 500 mcg.
[0011]
The feed for livestock according to the present invention is one to which an additive for livestock feed consisting of licorice powder and β-glucan powder is added.
[0012]
Further, in the present invention, the livestock feed is obtained by adding 50 mcg to 500 mcg of licorice powder to 1 g of the base feed, and adding 100 mcg to 500 mcg of β-glucan powder to 1 g of the base feed.
[0013]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, embodiments of the present invention will be described.
[0014]
Embodiment 1 FIG.
[0015]
The additive for livestock feed according to the present embodiment is a mixture of licorice powder (glycyrrhizin content of 3 to 5%) and β-glucan powder.
[0016]
The mixing ratio of the licorice powder and the β-glucan powder is preferably 50 mcg to 500 mcg of the licorice powder and 100 mcg to 500 mcg of the β-glucan powder. When the licorice powder ratio is less than 50 mcg, the efficacy is reduced, and when it exceeds 500 mcg, the stimulation of the immune system is increased, and there is a concern about immune tolerance and safety. If the β-glucan powder ratio is less than 100 mcg, the efficacy is reduced, and if it exceeds 500 mcg, the stimulation of the immune system is increased, and there is a concern about immune tolerance and safety. More preferred is 100-200 mcg of β-glucan powder for 50-200 mcg of licorice powder.
[0017]
As the licorice, it is preferable to use Glycyrrhiza glabra or Tohoku licorice (Glycyrrhiza uralensis).
[0018]
If the additive for livestock feed according to the present embodiment is added to the base feed of livestock and given to livestock, livestock with high disease resistance can be bred.
[0019]
Embodiment 2 FIG.
[0020]
The feed for livestock according to the present embodiment is obtained by adding the additive for livestock feed in the first embodiment to a base feed of livestock.
[0021]
The addition amount of licorice powder (glycyrrhizin content 3 to 5%) may be 50 mcg to 500 mcg, more preferably 50 mcg to 200 mcg, based on 1 g of the base feed, and the addition amount of β-glucan powder may be 1 g of the base feed. On the other hand, it may be 100 mcg to 500 mcg, more preferably 100 mcg to 200 mcg.
[0022]
If the feed for livestock according to the present embodiment is given to livestock, livestock with high disease resistance can be bred.
[0023]
【Example】
Examples 1 to 7, Comparative Examples 1 to 5.
[0024]
In the piglets on the farm where the test was carried out as a present example and a comparative example, the antibodies against swine influenza virus rose from the age of 40 days, became positive in all animals at the age of 70 days, and influenza H3N2 from the time when the transfer antibody was cut off. Have been confirmed to be infected. There are 12 groups, 11 groups with 5 piglets here as one group (Examples 1 to 7 and Comparative Examples 1 to 4) and 1 group with 9 piglets as one group (Comparative Example 5). Piglets were grouped.
[0025]
In each pig group, after measuring the weight of each pig at the age of 25 days, the amount of β-glucan shown in Table 1 (Examples 1 to 7) and Table 2 (Comparative Examples 1 to 5) per 1 g of base feed A livestock feed to which a livestock feed additive consisting of powder (macroguard: trade name: BIO TEC Co., Ltd.) and Tohoku licorice powder (Ogi Pharmaceutical Co., Ltd., glycyrrhizin content: 3 to 5%) is added. Each pig group was fed from piglets 25 days old to 50 days old, and the body weight of each pig at 50 days of age was measured. Then, blood was collected at 70 days of age to measure antibodies against influenza H3N2 virus (serum antibody test). The results are shown in Tables 1 and 2 and Table 3 showing the average value of each pig group.
[0026]
[Table 1]
[Table 2]
[Table 3]
The serum antibody test for influenza H3N2 was carried out according to the ELISA method, and the virus antigen was adsorbed and immobilized on a microplate for ELISA. Then, the test serum was used as the primary antibody, and the POD-labeled anti-swine IgG antibody was used as the secondary antibody. And the color was determined by the enzyme antibody method. The degree of color development was visually determined, and the antibody titer was determined semi-quantitatively as-(negative), ± (false positive), + (weak positive), +2 (strong positive). If the ELISA antibody is low in titer, if not detected, it indicates that the virus has not grown in the pig.
[0030]
Safety was judged by the difference in body weight between the 25-day-old and the 50-day-old, and the efficacy was judged by the antibody titer.
[0031]
From Table 3, it is safer to add the additive for livestock feed in which Tohoku licorice powder is mixed with 50 mcg to 500 mcg and β-glucan powder is mixed with 100 mcg to 500 mcg, as compared with the case where Comparative Examples 1 to 4 are added alone and Comparative Example 5 is not added. It can be confirmed that comprehensively favorable results were obtained in terms of properties and efficacy, and furthermore, the most favorable results were obtained in livestock feed additives of 50 mcg to 200 mcg of Tohoku licorice powder and 100 mcg to 200 mcg of β-glucan powder. Can be confirmed.
[0032]
Examples 8 to 14, Comparative Examples 6 to 10.
[0033]
Poultry farms in which chicken infectious laryngeal bronchitis virus (IBV) M strain and Y strain have been infected between 30 and 50 days of age of laying chicks (Isa Brown), and an increase in antibody titer has been confirmed in all groups In the above, 12 groups of 11 groups of 10 chicken chicks as one group (Examples 8 to 14 and Comparative Examples 6 to 9) and 1 group of 20 chicken chicks as one group (Comparative Example 10) Chicken chicks were divided into groups.
[0034]
In each group of chickens, β-glucan powder (macroguard: trade name: manufactured by BIO TEC Co., Ltd.) in the amount shown in Table 4 (Examples 8 to 14 and Comparative Examples 6 to 10) per 1 g of base feed and Tohoku Livestock feed supplemented with livestock feed additives consisting of licorice powder (Ogi Pharmaceutical Co., Ltd., product: glycyrrhizin content 3-5%) is fed for each chicken group from 20 days old to 50 days old. Then, blood was collected at 60 days of age to measure antibodies to IBV. Table 4 shows the results.
[0035]
[Table 4]
The measurement of antibodies to IBV was carried out using an IBV ELISA kit (Gen Corporation). The antibody against IBV was measured by ELISA, and the absorbance measured by the two-wavelength method was negative (-) for 0.2 or less, positive (+) for 0.21 to 1.0, and strong for 1.0 or more. It is determined as positive (+2). The safety was judged by the egg laying results, and the efficacy was judged by the antibody titer.
[0037]
From Table 4, the addition of the additive for livestock feed in which the Tohoku licorice powder was added in an amount of 50 mcg to 500 mcg and the β-glucan powder was added in an amount of 100 mcg to 500 mcg, as compared with the case where Comparative Examples 6 to 9 were added alone and Comparative Example 10 was not added It can be confirmed that favorable results were obtained in terms of sex, and furthermore, a remarkable difference was observed in additives for livestock feed between 50 mcg to 200 mcg of Tohoku licorice powder and 100 mcg to 200 mcg of β-glucan powder, and the most favorable results were obtained. Can be confirmed. There was no difference according to the egg laying results. That is, there was no problem in safety.
[0038]
【The invention's effect】
Advantageous Effects of Invention According to the present invention, it is possible to provide an additive for livestock feed capable of raising safer and highly effective livestock with high disease resistance and a livestock feed obtained by adding the additive. .
[0039]
Therefore, it can be said that the industrial applicability of the present invention is very high.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002295252A JP2004129518A (en) | 2002-10-08 | 2002-10-08 | Feedstuff additive and feedstuff |
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| JP2002295252A JP2004129518A (en) | 2002-10-08 | 2002-10-08 | Feedstuff additive and feedstuff |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008536508A (en) * | 2005-04-21 | 2008-09-11 | デソル ベスローテン フェンノートシャップ | Methods for improving animal fertility |
| WO2009144467A1 (en) * | 2008-05-29 | 2009-12-03 | Med-Eq As | Composition comprising 1, 3 /1, 6 beta glucan for reducing weight |
| JP2011050273A (en) * | 2009-08-31 | 2011-03-17 | Japan Health Science Foundation | New urals glycyrrhiza, and stolon for cultivating the same |
-
2002
- 2002-10-08 JP JP2002295252A patent/JP2004129518A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008536508A (en) * | 2005-04-21 | 2008-09-11 | デソル ベスローテン フェンノートシャップ | Methods for improving animal fertility |
| WO2009144467A1 (en) * | 2008-05-29 | 2009-12-03 | Med-Eq As | Composition comprising 1, 3 /1, 6 beta glucan for reducing weight |
| US8318218B2 (en) | 2008-05-29 | 2012-11-27 | Medeq As | Composition comprising 1,3/1, 6 beta glucan for reducing weight |
| AU2009252911B2 (en) * | 2008-05-29 | 2014-09-04 | Med-Eq As | Composition comprising 1, 3 /1, 6 beta glucan for reducing weight |
| AU2009252911C1 (en) * | 2008-05-29 | 2015-01-22 | Med-Eq As | Composition comprising 1, 3 /1, 6 beta glucan for reducing weight |
| JP2011050273A (en) * | 2009-08-31 | 2011-03-17 | Japan Health Science Foundation | New urals glycyrrhiza, and stolon for cultivating the same |
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