JP2004089724A - Organism magnetic field measuring apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an organism magnetic field measuring apparatus having proper operability. <P>SOLUTION: This organism magnetic field measuring apparatus includes a plurality of magnetic sensors each for measuring a magnetic field generated from the heart of an organism, a computer for processing the measured magnetic field waveform, and a display means for displaying the processing of the computer. The computer adopts a time point when a rise of a QRS wave of a systole of the heart of the measured magnetic field waveform coincides with a threshold value, a time point when a fall of the QRS coincides with a threshold value, or a peak position time point of the QRS wave as a reference, traces back to a predetermined time (t<SB>off</SB>) from this time point, obtains the magnetic field waveform measured from a time point t<SB>1</SB>over the QRS wave up to a predetermined time point t<SB>2</SB>at a channel corresponding to each magnetic sensor, obtains an equal propagation time diagram for connecting from the time point t<SB>1</SB>at the propagating time to the peak position time point of the QRS wave for the channel corresponding to each magnetic sensor, and displays the equal propagation time diagram on a display means. Thus, the time point of the reference of the magnetic field waveform can be automatically set. <P>COPYRIGHT: (C)2004,JPO

Description

The present invention relates to a biomagnetic field measuring method and a biomagnetic field measuring apparatus suitable for measuring a biomagnetic field generated by a current in a living body such as a brain activity of a living body or a myocardial activity of a heart.

The distribution of a weak magnetic field generated from a living body is measured using a superconducting quantum interference device (SQUID), which is a conventional magnetic sensor, and the position of the active current inside the living body is estimated from the measurement result. A multi-channel biomagnetic imaging apparatus for imaging is known. Such a conventional example is disclosed in, for example, JP-A-4-319334 or JP-A-5-146416.

JP-A-4-319334

JP-A-5-146416

The above-mentioned conventional example relates to the operation principle of a biomagnetic imaging apparatus, and does not disclose a technical problem or a solution for implementing the invention in its disclosure contents. Further, the above-mentioned conventional example relates to a biological activity current generated inside the brain, and does not specifically disclose other parts. An object of the present invention is to provide a biomagnetic field measuring method and a biomagnetic field measuring apparatus which can easily measure magnetic field strengths at a plurality of measurement positions and have good operation. SUMMARY OF THE INVENTION An object of the present invention is to provide a biomagnetic field measuring apparatus that can easily display a magnetic field diagram of a living body from the magnetic field strengths at a plurality of measurement positions and that is easy to operate. It is an object of the present invention to provide a biomagnetic field measurement apparatus including a biomagnetic field map display device that can be executed.

Another object of the present invention is to provide a biomagnetic field measurement apparatus capable of performing averaging processing by a quick operation while confirming whether or not an intended waveform appears in one or a plurality of measured magnetic field waveforms and averaging processing is possible. In particular, it is an object of the present invention to provide a biomagnetic field measuring device that improves the efficiency of peak detection. Another object of the present invention is to provide a display capable of reconfirming the result of the peak position used in the averaging process during or after the averaging process on a magnetic field waveform, and to perform a biomagnetic measurement capable of accurately analyzing the biomagnetic field. It is to provide a device. It is another object of the present invention to provide a biomagnetic field measuring apparatus capable of measuring a magnetic field emitted from a living body simultaneously with an electrocardiogram.

The present invention provides a method of measuring a magnetic field generated from a living body of a subject at a plurality of positions, a procedure of displaying a plurality of measurement positions on a display screen, and selecting a position to be displayed from the displayed measurement positions. And displaying the information on the magnetic field strength at the selected position, and displaying the plurality of measurement positions together with the presence or absence of the selection in a display state of the information on the magnetic field strength. . The present invention is characterized in that a channel item corresponding to the channel displayed on the analysis data display section is provided on the operation area display section. Another feature is that other measurement items are provided. The present invention specifically provides the following biomagnetic field measuring apparatus.

The present invention relates to a biomagnetic field measuring apparatus including a biological magnetic field map display device that displays a magnetic field map by measuring a biomagnetic field at a plurality of positions, wherein the magnetic field map display device displays a processing function item indicating a processing function item including measurement. Unit, an analysis data display unit that displays a measured biomagnetic field and a processing magnetic field obtained by processing the same, and an operation area display unit that displays operation items corresponding to the processing magnetic field. A channel corresponding to each magnetic sensor is displayed on the analysis data display section, a selected channel item is displayed on the operation area display section, and the selected channel item is displayed on the analysis data display section. And means for selecting a channel item from the displayed selected channel items, the channel item being associated with a channel displayed in Selecting measurement items of management function display portion, the channel on the analysis data display unit, and the selected channel item provides biomagnetic field measuring device with a means for displaying the channel item.

Preferably, the channel and the channel item are composed of correlated rows and columns. Preferably, there is provided means for identifying a channel item consisting of a row or a column selected from the selected channel items or one channel item from another. Preferably, the pull-down menu of the measurement item includes “adjustment value file”, “fully automatic adjustment”, “offset voltage _Voff adjustment”, “manual adjustment”, “adjustment value file”, “measurement panel”, “automatic waveform diagnosis”. , And "AFA offset adjustment". Preferably, a measurement item for instructing start and stop is displayed on the operation area display unit, and the measurement is started by the start instruction, and the measurement is stopped by the stop instruction. Preferably, the analysis data display unit includes an automatic waveform diagnostic means for issuing an identification signal when the display screen is out of the specified range, as an inappropriate channel for the measurement.

The present invention relates to a biomagnetic field measuring apparatus having a biomagnetic field map display device for measuring a biomagnetic field at a plurality of positions and displaying a magnetic field map as a processing result, wherein the magnetic field map display device has a processing function including measurement. It consists of a processing function display unit that shows items, and an analysis data display unit that displays the measured biomagnetic field and the processing magnetic field obtained by processing the biomagnetic field. Select and execute the submenu, and select “Single waveform display” in the “Data analysis” menu in the analysis data display section.
, A "grid map display", a "isomagnetic map", and a "propagation time diagram" are provided.

In the present invention, before performing the averaging process, the digital filter or the analog filter is used to perform a filtering process to remove the fluctuation of the magnetic field waveform due to the respiration and the fluctuation of the magnetic field waveform due to the frequency of the commercial power supply (for example, 50 Hz). And the accuracy of the averaging process can be improved. Further, in the present invention, as a method of peak detection, a point where the peak is maximum in a certain time range (maximum peak detection), a point where the peak is minimum (minimum peak detection), and a positive cross point with the threshold (from the threshold By adopting four types of peak detection methods that detect a point of change from a small value to a large value) and a negative cross point with a threshold value (a point of change from a value larger than the threshold value to a smaller value), the peak detection rate can be reduced. Improve. In the present invention, a mark is turned on at the peak or cross point of the magnetic field waveform used for the averaging process, and the appropriateness of the result of the process can be confirmed again on the display screen. Further, in the present invention, the measurement circuit body of the electrocardiogram is arranged outside the shield room, and only the electrodes and wiring portions made of a nonmagnetic material for detecting the electric potential of the living body are arranged inside the shield. It is possible to measure the biomagnetic field generated from the living body simultaneously with the electrocardiogram.

Further, the biomagnetic field measuring apparatus according to the present invention is a biomagnetic field measuring apparatus comprising: a plurality of magnetic sensors for measuring a magnetic field emitted from a living body; and display means for displaying a magnetic field measured by the plurality of magnetic sensors. The magnetic field waveform obtained by averaging the measured magnetic field waveform and the measured magnetic field waveform are displayed on the same screen of the display means in a time range including the peak position of the measured magnetic field waveform. Having a means for storing the measured magnetic field waveform and the magnetic field waveform after the averaging process, and determining the peak position of the magnetic field waveform after the averaging process. And the second mark indicating the peak position of the measured magnetic field waveform not used in the averaging process is displayed. A time range including the peak position is superimposed on the measured magnetic field waveform, and the time range including the peak position indicates a start time and an end time of the averaging process, respectively. The measured magnetic field waveform as a line substantially parallel to the time axis indicating a time range between the start point and the end point, together with first and second lines intersecting the time axis of the measured magnetic field waveform. The averaging process is performed after filtering the measured magnetic field waveform. Further, the biomagnetic field measuring apparatus of the present invention repeatedly measures a magnetic field generated from a living body. A biomagnetic field measuring apparatus, comprising: a plurality of magnetic sensors for performing measurement; and display means for displaying a magnetic field measured by the plurality of magnetic sensors. By specifying a time range including a peak position appearing in a magnetic field waveform repeatedly measured by a predetermined magnetic sensor in the sensor, the time range appearing in the magnetic field waveform repeatedly measured by each magnetic sensor of the plurality of magnetic sensors is designated. An averaging process is performed for each magnetic field waveform repeatedly measured by each of the magnetic sensors over the time range including the peak position, and the averaging process is repeatedly performed by any one or a plurality of magnetic sensors among the plurality of magnetic sensors. A magnetic field waveform obtained by the averaging process on the magnetic field waveform and a magnetic field waveform repeatedly measured by the arbitrary one or more magnetic sensors are displayed on the same screen of the display means; A first mark indicating a peak position appearing in the magnetic field waveform after the averaging process is displayed. A second mark indicating a peak position appearing in the measured magnetic field waveform not used for the averaging process is displayed, and the time range including the peak position is determined by the measured magnetic field. It is also characterized in that it is superimposed on the waveform and that the averaging process is performed after filtering is performed for each magnetic field waveform repeatedly measured by the magnetic sensors.

Further, the biomagnetic field measuring apparatus of the present invention is a biomagnetic field measuring apparatus comprising: a plurality of magnetic sensors for repeatedly measuring a magnetic field generated from a living body; and display means for displaying a magnetic field measured by the plurality of magnetic sensors. And specifying a time range including a peak position appearing in a magnetic field waveform measured by a predetermined magnetic sensor among the plurality of magnetic sensors to thereby obtain a magnetic field waveform measured by each magnetic sensor of the plurality of magnetic sensors. Averaging processing is performed for each magnetic field waveform measured by each of the magnetic sensors over the time range including the peak position appearing at the position, and measurement is performed by any one or a plurality of magnetic sensors among the plurality of magnetic sensors A magnetic field waveform obtained by performing the averaging process on the obtained magnetic field waveform and the arbitrary one or more magnetic sensors Characterized in that the further measured magnetic field waveform is displayed on the same screen of the display unit.

Further, a biomagnetic field measuring apparatus according to the present invention includes a plurality of magnetic sensors for measuring a magnetic field generated from the heart of a living body, and a display unit for displaying a magnetic field waveform measured by the plurality of magnetic sensors. In the above, the display means includes an analysis data display unit for displaying a magnetic field waveform obtained by processing the measured magnetic field waveform and the measured magnetic field waveform, and an analysis data display unit for analyzing the data of the measured magnetic field waveform. An operation area display section for displaying operation items indicating items, displaying the measured magnetic field waveform on the analysis data display section as rows or columns of a plurality of channels, and selecting a desired one of the plurality of channels from the plurality of channels. A channel is designated as a channel to be used as a reference for the averaging process. And executes the averaging process Te. With reference to FIG. 38, the biomagnetic field measuring apparatus of the present invention is summarized as follows. A numerical value is entered in the text box 103a of the averaging object 103 to set a peak detection threshold 180, and a peak detection method is set by a toggle button 103b. The averaging time width is set by inputting a number into the text box 103c, and inputting a number into the text box 103d to set the time width before peak detection. Press the button 103e to perform the calculation. After the end of the peak detection, the values of 103c and 103d are displayed in the waveform 106a displayed in the waveform display area 106 according to the averaging range B1, the maximum time B2, and the minimum time B3. Marks C1 to C4 are displayed. The averaging process is executed by pressing the button 103f. An averaging waveform 107a is displayed in the averaging display area 107. The averaging process is also performed on all the waveforms of the channels not displayed in the region 106 or the region 107 at the same time. As a result, an averaging process can be performed while confirming the measured magnetic field waveform, and a biomagnetic field measuring device that can accurately analyze the biomagnetic field with a quick operation can be realized.

According to the present invention, there is provided a method for easily measuring the magnetic field strength at a plurality of measurement positions and having good operability. According to the present invention, since the channel items corresponding to the channels displayed on the analysis data display section are provided, the measurement and display operation can be easily performed by the correspondence between the channels and the channel items. Further, according to the present invention, it is possible to improve the efficiency of peak detection and the accuracy of peak detection, and it is possible to reconfirm whether the result of peak detection processing and the result of averaging processing are appropriate. Further, according to the present invention, an electrocardiogram and a biomagnetic field can be simultaneously measured.

FIG. 1 shows a schematic configuration of an embodiment of a biomagnetism measuring apparatus according to the present invention. In order to remove the influence of environmental magnetic noise, the biomagnetic measurement device is installed in the magnetic shield room 1. A subject (a subject composed of a living body) 2 is measured while lying on the bed 3. The body surface of the subject (in the case of the chest, generally parallel to the chest wall) is assumed to be substantially parallel to the surface of the bed 3, and this surface is defined by the xy plane of a rectangular coordinate system (x, y, z). It is assumed that they are parallel. Although the subject's chest is curved and inclined, it is assumed to be substantially parallel for ease of explanation. Above the chest of the subject 2, a dewar 4 filled with a liquid He as a refrigerant is arranged, and the dewar is a superconducting quantum interference device (
A plurality of magnetic sensors including a SQUID (Superconducting Quantum Interference Device) and a detection coil connected to the SQUID are accommodated. The liquid He is continuously replenished from the automatic replenishing device 5 outside the magnetic shield 1.

The output of the magnetic sensor outputs a voltage having a specific relationship with the strength of the biomagnetic field (which can also be considered as a magnetic flux density) generated from the subject 2 and detected by the detection coil, and the output is FLL (Flux). (Locked loop) circuit 6. The FLL circuit 6 cancels a change in the biomagnetic field (biomagnetism) input to the SQUID via a feedback coil so as to keep the output of the SQUID constant (this is called a magnetic field lock). By converting the current flowing through the feedback coil into a voltage, a voltage output having a specific relationship with a change in the biomagnetic signal can be obtained. Since the detection is performed via the feedback coil as described above, a weak magnetic field can be detected with high sensitivity. The output voltage is input to an amplifier / filter / amplifier (AFA) 7, the output of which is sampled, A / D converted, and taken into a computer 8.

The computer 8 is composed of a personal computer, 8-1 is a display unit, 8-2 is a keyboard, and 8-3 is a mouse. The mouse 8-3 is used to select a processing target by moving a cursor on the screen. This operation can also be performed by operating the keyboard. AFA7 input gain (I _gain ) and output gain (O _gain )
_gain ) is adjustable, and the AFA 7 is a low-pass filter (LPF) that passes frequency signals below the first reference frequency, and passes frequency signals above the second reference frequency that is lower than the first reference frequency. Includes a high-pass filter (HPF) and a notch filter (BEF) that cuts off the commercial power frequency. The computer 8 can perform various types of processing, and the processing results can be displayed on the display unit 8-1. Note that the computer 8 shown in FIG. 1 shows one embodiment, and the present invention is not limited to this. For example, a device having a display having a touch panel, or a device using another coordinate pointing device, such as a trackball or a joystick, instead of a mouse may be used. In some cases, a computer connected via a public telephone line may be used.

As the SQUID, for example, a DC SQUID is used as an example. When an external magnetic field is applied to the SQUID, a DC bias current ( _Ibias ) is supplied to the SQUID so that a voltage (V) corresponding to the external magnetic field is generated. When the external magnetic field is represented by a magnetic flux Φ, a characteristic curve of V with respect to Φ, that is, a Φ-V characteristic curve is given by a periodic function. Prior to the measurement, the offset voltage (V _OF
An operation of adjusting _F ) to make the DC voltage of the Φ-V characteristic curve zero level is performed.
Further, the offset voltage (A _OFF ) of the AFA 7 is adjusted so that when the input of the AFA 7 is zero, the output becomes zero. When a large magnetic field is applied to the SQUID from the outside, the magnetic field is trapped on the device of the SQUID and its normal operation is not performed. In that case, the SQUID can be heated to a normal state once, and then the heating can be stopped to remove the trapped magnetic field. In this case, the SQUID heating operation is called a heat flash.

FIG. 2 shows the arrangement of the magnetic sensors. The detection coil of the magnetic sensor has a coil for detecting a tangential component of the biomagnetic field (a component substantially parallel to the xy plane) and a normal component of the biomagnetic field (perpendicular to the xy plane). Component). As the coil for detecting the tangential component of the biomagnetic field, two coils whose coil surfaces are oriented in the x direction and the y direction are used, and as the coil for detecting the normal component of the biomagnetic field, the coil surface is in the z direction. Are used. A plurality of magnetic sensors 20-1 to 20-8, 21-1 to 21-8, 22-1 to 22-8, 23-1 to 23-8, 24-1 to 24-8, 25-1 to 25 As shown in FIG. 2, -8, 26-1 to 26-8 and 27-1 to 27-9 are arranged in a matrix on the body surface, that is, a surface substantially parallel to the xy plane. The number of magnetic sensors may be arbitrary, but in FIG. 2, since the matrix of magnetic sensors is composed of 8 rows and 8 columns, the number of magnetic sensors is 8 × 8 = 64. As shown in FIG. 2, each magnetic sensor is arranged so that its longitudinal direction coincides with the body surface, that is, the direction (z direction) perpendicular to the xy plane. In this embodiment, the bed surface and the XY surface of the sensor are parallel to each other. However, in order to increase the measurement accuracy, it is better to approach the body, and the bed can be inclined. However, since the human body, which is the subject, is always moving, if the human body is brought into close contact with the human body, this movement will move the detection unit, and it will be difficult to perform highly accurate detection.

Figure 3 shows the structure of a sensor for detecting the respective magnetic sensors, a normal component B _z of the biomagnetic field. In the figure, a coil made of a superconducting wire (Ni-Ti wire) is arranged so that its coil surface faces the z direction. This coil is composed of a combination of two coils 10 and 11 having opposite directions. The coil 10 closer to the subject 2 is a detection coil, and the coil 11 farther away is a reference coil for detecting external magnetic field noise. You. The external magnetic field noise originates from a signal source farther than the subject, so that the noise signal is detected by both the detection coil 10 and the reference coil 11. On the other hand, the magnetic field signal from the subject is weak. Therefore, the biomagnetic signal is detected by the detection coil 10, but the reference coil 11 is hardly sensitive to the biomagnetic signal. For this reason, since the detection coil 10 detects the biomagnetic field signal and the external magnetic field noise signal, and the reference coil 11 detects the external magnetic field noise signal, the difference between the signals detected by both coils is used to obtain the S / N ratio. Measurement of a high biomagnetic field becomes possible. These coils are connected to the SQUID input coil through the superconducting wire of the mounting board mounted with SQUID12, whereby the normal direction component B _z of the detected biomagnetic field signal is transmitted to the SQUID.

Figure 4 shows the structure of a sensor for detecting the respective magnetic sensors, the tangential components B _x and B _y of the biomagnetic field. In the figure, a planar coil is used in a sensor for detecting a biomagnetic component in a tangential direction. That is, the detection coils 10 'and 10 "and the reference coil 11
'And 11 "consist of planar coils which are respectively arranged in first and second planes which are spaced apart in the z-direction. These coils have SQUIDs 12' and 12" as well as for the normal component. Connected to the input coil of the mounting board. 4 two surfaces perpendicular to each other prism, these B _x component sensor 13 and By sensor 14 for component detection for detection affixed, thereby capable of detecting B _x component and the B _y component sensor is formed . Tangential components Bx, for By, besides detected using a magnetic sensor shown in figure 4, the normal component B _z obtained by the magnetic sensor of FIG. 3 x
, Y may be obtained by partial differentiation. In this case it can be detected by measuring both a single magnetic sensor tangential components B _x, and B _y and the normal component B _z is.

FIG. 5 shows the positional relationship between the magnetic sensor and the chest 30 which is the measurement section of the subject 2. The points shown represent the intersections of the rows and columns on the matrix shown in FIG. 2, that is, the measurement points of the subject 2, that is, the measurement positions. Each of these measurement positions is also called a channel. As can be seen from the figure, in this embodiment, the height direction of the subject 2 is defined as the y direction, and the lateral direction of the subject 2 is defined as the x direction.

FIG. 6 shows a measurement result of the biomagnetic field at each measurement position shown in FIG. This measurement result shows the time-varying biomagnetic field waveform obtained by performing the above processing based on the signals detected by the magnetic sensors corresponding to each measurement position for each corresponding channel in the matrix. Things. In this embodiment, since each channel is provided at a position where the magnetic field generated by the heart muscle can be detected, the waveform in FIG. 6 shows the magnetocardiogram waveform. The waveform obtained by measuring the magnetic field generated from the heart muscle is called a magnetocardiogram waveform. As shown in FIG. 6, when the measurement data measured for each channel is displayed corresponding to the position for each channel, this is called a grid map display. FIG. 6 shows the waveform of the measurement result of the magnetocardiogram for a certain healthy person. Here (a) shows a magnetocardiogram of tangential components B _x, (b) is a magnetocardiogram waveform of the tangential component B _y, and (c) is a normal component B _z magnetocardiogram waveform respectively.

Figure 7 shows a magnetocardiogram particular 2 channels squeezed measured tangential components B _x for a healthy person. The solid line shows the magnetocardiogram waveform of one channel, and the dotted line shows the magnetocardiogram waveform of another channel. The time zone T1 during which the ventricle of the heart is depolarized, that is, the time of each waveform peak in the systolic QRS wave is shown as t _Q , t _R , and t _S , respectively. The time zone of the T wave, which is the heart repolarization process (diastole), is indicated as T2. When displaying the measured data, in addition to the grid map display, single-channel data may be displayed for each row or column, or data for all channels or multiple channels may be displayed in an overlapping manner. You may do it. The former is called a single waveform display, and the latter is called a superimposed waveform display.

With respect to the obtained magnetocardiogram waveform data, the result can be displayed by performing averaging (averaging) processing, creating an isomagnetic map, a time integral map, and the like based on the biomagnetic field. For example, referring to FIG. 7, a predetermined time (t _OFF ) goes back from the time when the rising part of the QRS wave coincides with the threshold value SL, and a predetermined time T3 elapses from the time t1 when the time goes back. The data up to the time t2 is added a predetermined number of times. This is averaging, and a predetermined time T3 is called an averaging time, and t _OFF is called an offset time. The magnetocardiogram waveform data may be integrated over a predetermined time range. A map formed by connecting points (channels) having the same time integration value is called an isochronous integration diagram. A map formed by connecting points having the same magnetocardiogram waveform signal value is called an isomagnetic diagram. Since each channel is set roughly, the interval between the isomagnetic lines, that is, the magnetic field intensity difference is set in advance, and linear interpolation is performed between the channels to draw isomagnetic lines, thereby creating a diagram more suitable for diagnosis. be able to. Referring to the magnetocardiogram waveform shown in FIG. 7, the time from time t1 to the peak position of the QRS wave (time t _R ) is called a propagation time, and a map formed by connecting points having the same propagation time is equal propagation. Call it a time diagram. The setting level of the threshold value SL can be changed. The time t1 is determined based on the time when the rising part of the QRS wave matches the threshold SL, but based on the time when the falling part of the QRS wave matches the threshold SL. You may decide. The time point t1 may be further determined by detecting a peak position time point (t _R time point) of the QRS wave and using this time point as a reference. The measured biomagnetic signal is generated by an electrophysiological phenomenon in a living body, and its source is approximated by a current dipole model. The current dipole of the magnetic field generation source is synthesized and displayed on the isomagnetic diagram, which is called a magnetic field source display.

A series of operations from registration of the subject to measurement of the data of the registered subject and analysis of the measured data are performed while looking at the display screen displayed on the display 8-1. Is Therefore, prior to the description of the series of operations, the layout of the display screen will be described first.

FIG. 8 shows a basic layout of a display screen displayed on the display 8-1 in FIG. The upper part of the display screen is occupied by a title bar part 801, a menu bar part 802, and a toolbar part 803 in which icons are arranged in order from the top. Each of the above units can be considered as a display area or area. These arrangements are commonly displayed on the display screen for other processing purposes, for example, registration and readout of a subject, measurement of a magnetic field, analysis of measurement data, and the like. This increases ease of use and reduces the time for measurement and processing. The central portion of the display screen is occupied by a subject information section 804, an analysis data section 805 for displaying analysis data such as diagrams and waveforms, and an operation area section 806 arranged in order from left to right. The lower portion is occupied by a status bar 807, which comprises a message bar portion 807-1 arranged on the left side for displaying a guide message relating to the next operation and a date / time display portion 807-2 arranged on the right side thereof. . Note that the message bar section 807-1 and the date and time display 807-2 may be one display area.

On the display screen in this embodiment, a title bar 801 that always displays the name of this system at the top, a menu bar 802 for performing basic operations of the system, and a frequency of use of the menu bar 802 are displayed. Since the toolbar 803, which allows high-level operations, is provided, the user does not need to search for an operation area every time the display screen changes, and can always know the currently operating system by looking at the top of the display screen. . Moreover, since the upper part of the display screen is the first place to look, assuming that a person reads a sentence, it is necessary to provide basic items in the operation of this system at the top. ， Improved usability in a natural way. In the center of the display screen, an analysis data display section 805, which is the main body of the display screen, is provided in the center to improve the visibility, and on the right side, an operation area specific to the display screen is provided. By providing 806, the arrangement is the same as the arrangement of the display screen and the operation area in the right-hand operation, so that the operation can be performed without discomfort. Therefore, even if this display screen is adopted as a display screen with a touch panel, the right hand operating the operation area unit 806 does not disturb the analysis data display unit 805. Similarly, since the subject information section 804 having only a confirmation function is provided on the left side of the analysis data display section 805, the operation can be executed while always confirming the patient. In addition, since the left position is the farthest position in the right hand operation, even if adopted for a display screen with a touch panel, the visibility of the display is not affected.

Further, the analysis data display unit 805 and the operation area unit 806 are replaced by the subject list and the data list of the subject only when the subject list is displayed (FIG. 24). When the subject list screen (FIG. 24) is displayed, the subject information section 804 always displays information on the subject on which the cursor is placed in the subject list in the screen. When analysis data such as a diagram or a waveform is displayed in the analysis data section (FIGS. 25 to 34), information on the subject who obtained the displayed analysis data is always displayed. Thus, the relationship between the displayed analysis data and the subject from which the analysis data has been obtained can be clearly known. As described above, on the display screen of this system, the subject information section 804 is always displayed at the fixed position (left side) of the display screen, similar to the menu bar section 802. There is no need to search for the subject information area every time it changes, and it can be known by always looking at the predetermined position (left side) on the display screen.

The title bar portion displays the name of the frame, specifically, the name “Multichannel MCG System” (FIGS. 24 to 34). Operation area 8
At 06, operation elements such as buttons and text boxes are arranged. The menu bar part is a part for selecting the operation menu, and the menu is “File (F)”, “
Edit (E) ”,“ List (L) ”,“ Data measurement (Q) ”,“ Data analysis (A)
And "Help (H)", and are arranged in the order of operation.

FIG. 9 shows the contents of each operation menu in the menu section on the display screen. The contents of these menus are displayed as pull-down menus by clicking the corresponding menu buttons. For this reason, when the operation menu is not required, only the keywords for calling the respective menus are compactly displayed in the menu bar section, so that the display area necessary for each operation such as the analysis data section and the operation area section is provided. Can be set widely. When an operation menu is required, the keywords arranged in accordance with the operation procedure can be selected and displayed from a menu bar, and the operation can be instructed. At this time, since the keywords are arranged according to an arrangement of characters (from left to right), the operation can be instructed in a natural manner.

The “File (F)” pull-down menu opens a page layout dialog box (not shown) and sets “Page layout (U)” for page layout, and “Preview (V)” for preview before printing. , "Print (P)" for data printing and Multichannel MCG System
Is terminated (“End of magnetocardiographic system (X)”). The “edit (E)” pull-down menu includes an item “delete (D)”. The measurement data of the subject in the subject list on the subject list screen (FIG. 24) is displayed in the data list on the same screen, but the item "Delete (D)" is displayed in the cursor in the data list. This is for deleting the data in which is placed, and the data must be selected in advance. Clicking this menu opens a confirmation dialog box asking if you want to delete it. If deletion is required, the "OK" button in the dialog box is clicked, and if the user wants to cancel the deletion, the "Cancel" button is clicked. The display and operation of the confirmation dialog box can reduce erroneous operations of deleting measurement data of the subject by mistake.

"List (L)" pull-down menu is "Registration (R)", "List (L)"
, “Delete (D)”, “Search (S)”, and “Cancel (X)”. When the “Register (R)” button in the pull-down menu is clicked, a subject registration dialog box shown in FIG. 10 is opened. This is used when registering data on the subject. Items that can be registered are the registration date, the subject's ID number up to a specified digit, name, date of birth, height, weight, gender, and disease. And the subject's comment indicating the classification information of the subject. When the "Register" button in the dialog box is clicked, the data entered for registration is registered, and all the input boxes are cleared so that re-entry is possible, and the "Cancel" button is clicked. Then, all the input boxes are cleared, and if the "end" button is clicked, the subject registration dialog box is closed. In the pull-down menu,
When "List (L)" is clicked, a subject list screen (FIG. 24) is displayed. “Delete (D)” in the pull-down menu is for deleting the subject on which the cursor is placed in the subject list on the subject list screen (FIG. 24), and is clicked. Before the deletion, a confirmation dialog box is displayed to confirm whether the file can be deleted in the same way as when "Delete (D)" in the pull-down menu is clicked. If deletion is required, the dialog box appears. The “OK” button is clicked, and the “Cancel” button is clicked to cancel the deletion. When the subject is deleted, all data in the data list for the subject is also deleted.

When "Search (S)" in the pull-down menu is clicked, a search dialog box shown in FIG. 11 is displayed. The subject and the data are searched, and only the searched subject and the data are displayed on the subject list screen. The subjects to be searched for the subject and the data are all subjects and all data. Data is retrieved by giving the subject name, registration date, gender, data type, measurement date, diagnosis result, comment, laboratory technician, body position, and the like as keywords. A compound search combining a plurality of the above keywords can be executed. "Release (X)" in the pull-down menu is used to release the display of only the retrieved subjects and data and display all subjects and all data. The pull-down menu of “Data measurement (Q)” is “Adjustment value file (F)”, “Fully automatic adjustment (
A), “V _OFF adjustment (V)”, “manual adjustment (M)”, “adjustment value file (F)”, “measurement panel (P)”, “automatic waveform diagnosis (D)”, and “AFA offset” Adjustment (O) ". When "Adjustment File (F)" is clicked,
A sub-pull-down menu containing "Open (O)", "Overwrite save (S)", and "Save as (A)" is displayed. “Open (O)” in the sub pull-down menu displays the system adjustment screen (FIG. 34), opens the specified adjustment value file, and sets the system adjustment values, that is, _Ibias and _VOFF , in the system. Used for "Save (S)" is used to open a confirmation dialog box and overwrite the current adjustment value to the currently opened adjustment value file. "
"Save as" (A) "is used to save the current adjustment value data to another adjustment value file by changing the name.

When the "fully automatic adjustment (A)" in the pull-down menu is selected, displays the system adjustment screen (FIG. 34), the offset voltage V _OFF of the bias current I _bias and FLL circuit 6 in accordance with the flow of FIG 22 described later automatic Is adjusted. "V _OFF adjustment (V)"
Is selected, the system adjustment screen (FIG. 34) is displayed, and the offset voltage V _OFF of the FLL circuit 6 is automatically adjusted according to the flow of FIG. 23 described later. When "manual adjustment (M)" is selected, a manual adjustment dialog box shown in FIG. 12 is opened. The operator selects the channel using the scroll bar and mouse, to change the bias current I _bias and offset voltage V _OFF. If there is no problem with the input value, click the "OK" button to set the value. "
If you click the Cancel button, your changes are invalidated and the dialog box closes.

When the "measurement panel (P)" is clicked, a data measurement screen including the grid map (FIG. 25) is displayed. When "automatic waveform diagnosis (D)" is clicked, an automatic diagnosis dialog box shown in FIG. 13 is opened. The automatic waveform diagnosis automatically checks the amplitude, median value, and period of the Φ-V characteristic curve in the display screen of FIG. 34, and displays the Φ-V characteristic curve when displaying or displaying the same curve in the latest state. At the time of updating, the channel outside the specified range is notified to the operator as a state unsuitable for measurement. If a channel in an inappropriate state for measurement is detected, an error dialog box is opened and an error message is displayed to notify the operator. However, the Φ-V characteristic curve of the channel is displayed in a different color and the The status may be indicated. When the minimum amplitude value is checked, when the difference between the maximum value and the minimum value in the Φ-V characteristic curve is smaller than the minimum amplitude value, it is determined that the state is inappropriate for measurement. When the median value is specified, the case where the absolute value of the average value of the maximum value and the minimum value is larger than the specified median value is regarded as an inappropriate state for measurement. When the period is specified, the measurement is not performed when the period of Φ in the Φ-V characteristic curve is out of the range specified by the first text box (lower limit) and the second text box (upper limit). It is assumed that it is in an appropriate state. To enable automatic diagnosis of the minimum amplitude, median and period, click the check box to the left of each item with the mouse so that the X mark is displayed, and enter the desired value in the corresponding text box. Enter The parameters of the automatic diagnosis input in this manner are enabled by pressing the “OK” button, and the dialog box is closed. When the "Cancel" button is pressed, the entered parameters are invalidated and the dialog box is closed. "AFA offset adjustment (O)" is used when adjusting the offset voltage AOFF of the AFA 7, and "AFA offset adjustment (O)" is used.
Is clicked, a data measurement screen (FIG. 25) belonging to the single waveform display is displayed. The pull-down menu of “Data Analysis (A)” is “Averaging (A)
)), "Single waveform display (W)", "Overlap waveform display (M)", "Grid map display (G)", "Equimagnetic field diagram (B)", "Time integration diagram (T)", "Propagation time diagram (P)
, "Magnetic field source display (S)", "Line mode (L)", and "Fill mode (F
)"including.

When "Averaging (A)" is clicked, the averaging screen (Fig. 27)
However, when "Single waveform display (W)" is clicked, a single waveform display character screen (Fig. 28)
However, when the “overlay waveform display (M)” is clicked, the overlay waveform display screen (FIG. 29) is displayed, and when the “grid map display (G)” is clicked, the grid map display screen (FIG. 29) is displayed.
30) are displayed, and a check mark (x) is displayed on the left side of the menu to indicate that the selection has been made. Clicking on “Equimagnetic field diagram (B)” displays the isomagnetic diagram screen (FIG. 31), and clicking on “Time integral diagram (T)” displays the isochronous diagram screen (FIG. 32). , "Propagation time diagram (P)" is clicked, an equal propagation time diagram screen (FIG. 33) is displayed, and a check mark (x) indicating that the selection is made is displayed on the left side of the menu. Also, when "magnetic field source display (S)" is clicked, an inverted triangle mark is displayed on the left side of the menu, and when displaying the isomagnetic map, the magnetic field source approximated by the current dipole is superimposed and displayed (Fig. None). When “Line mode (L)” is selected, the screen of the isomagnetic diagram, isochronous integration diagram, isopropagation time diagram, and magnetic field source display is displayed without filling in the lines, and the “filling mode (F )] Is selected, the line is displayed in a filled state. A check mark is displayed on the left side of the menu to indicate the current mode.

The “Help (H)” pull-down menu includes “Contents (C)”, “Search by keyword (S)” and “Version information (A)”. Used to search for and to open the version dialog box. In the toolbar 803, “subject registration” (808), “subject list” (809), “print” (810), “preview” (811), “system adjustment” (812), and “data measurement” (813)
, “Data analysis” (814) icon is arranged. Although these are not shown, they are linked to the functions of the menu, and the frequently used items from the pull-down menu can be selected. That is, “subject registration” (808) is “registration (R)” of “list (L)”, and “subject list” (809) is “list (L)” of “list (L)”. And "Print" (810) are the same as "File (F)"
“Print (P)”, “Preview” (811) are “Preview (V)” of “File (F)”, and “System adjustment” (812) is “Manual adjustment (M) of“ Data measurement (Q) ”. ) "," Data measurement "(813) is" Measurement panel (P) "of" Data measurement (Q) ", and" Data analysis "(814) is" Data analysis (A) ".
"Grid map display (G)" respectively. As described above, the menu linked to the icon can be selected by simply clicking the icon. Therefore, operations that are frequently used can be easily operated simply by clicking on the icon adjacent to the analysis data display section, and can be operated with icons that are easy to recognize in a shorter time than the operation of the menu bar section. The icon may be selected by the user, and the frequency of use (
The number of times may be automatically displayed on the toolbar 803.

Next, a series of operations from the registration of the subject to the measurement of the data of the registered subject and the analysis of the measured data, including the adjustment operation of the system, are shown in FIGS. This will be described with reference to FIG.

FIG. 16 shows a flow of the entire operation. When the power of the computer 8 is turned on (S-1), the operating system is started up and a program start icon is displayed on the display unit 8-1. (S-2). Mu from the icon
When the program icon of the ltichannel MCG System is selected (S-3), the subject list screen shown in FIG. 24 is displayed instead (S-).
4). In the system according to this embodiment, a subject list screen shown in FIG. 24 is displayed as an initial screen at the start of the system. The reason for this is that the relationship between the subject and the measurement or analysis data of the subject is extremely important, and thus this system manages the subject information as keywords. That is, measurement data and analysis data cannot be managed without subject information. For this reason, in this system, the subject is first registered on the subject list screen, or the subject is specified when the subject is registered, and then, when a new measurement is performed, the process shifts to measurement, and the measurement data is already stored. If there is, specify the target data. It is to be noted that a display screen for waiting time at system startup may be provided prior to the subject list screen, and a display screen serving as a table of contents of the system may be provided.

Explaining the subject list screen shown in FIG. 24, the subject information section is occupied on the left side. The subject list is displayed at the top of the entire right side, and the data list is displayed at the bottom. Items displayed in the subject information section are the same as those described with reference to FIG. Items in the subject list include ID (subject ID number), name, registration date (date of data registration), number of measurements (number of times data was measured), date of birth, age, and height , Weight, comments (comments on the subject), etc. The subject list can be scrolled with a vertical scroll bar, and the subject list items can be scrolled with a horizontal (horizontal) scroll bar. The row of the selected subject is highlighted. The items in the data list relating to the selected subject include ID, data type (raw (raw) data or averaging (averaging)), and sampling interval (in milliseconds of the signal when data measurement was performed). , Sampling time (seconds), classification (disease classification information), Date and Time (date and time when data measurement was performed), comments (data comments), and the like. The data list can be scrolled with a vertical scroll bar, and the data list items can be scrolled with a horizontal (horizontal) scroll bar. The row of the selected data is highlighted.

According to the subject list screen, information of each subject is displayed on the subject list in one line. As a result, the information of the subjects arranged vertically can be clearly separated, so that the discriminability can be improved. For example, an erroneous operation of selecting another subject by mistake can be reduced. The information of each subject can be scrolled with a horizontal (horizontal) scroll bar, and the information of the selected subject is arranged vertically in the vertically long subject information section for each item, so that visibility is impaired. There is no. In this case, the visibility of the subject may be further improved by moving the items of the data list of each subject back and forth (left and right). Further, by displaying information of each subject on one line, many subjects can be seen at a time, so that the number of times of scrolling with the vertical scroll bar can be reduced. In addition, the data can be displayed in the lower data list by a simple operation of simply placing the cursor on the subject list from which the user wants to select data on the desired subject from the subject list and clicking. Moreover, since the subject list and the data list are arranged vertically, movement of the line of sight can be reduced, so that the relevance can be easily recognized. Also, the size of the data list can be freely changed by a simple operation of moving the cursor to the upper part of the area and dragging, so that the size can be freely set according to the number of data lists. it can.

In step S-5, a desired subject line is selected from the subject list on the subject list screen. In the case of averaging processing described later, a row of raw data in the data list is always selected. Thereafter, the flow is branched into four by the menu (S-6). According to one of the branches, the submenu "End of magnetocardiography (X)" of the menu of "File (F)" is selected, and in this case, end processing such as closing the window is performed (S-7). ), Whereby the system is shut down (S-8). Thereafter, the power of the computer 18 is turned off (S
-9), all ends. According to the rest of the branches, the averaging process (S-10
), Data analysis (S-11) and data measurement (S-12). The averaging process can be executed by selecting a submenu of “Averaging (A)” in the menu of “Data analysis (A)”. For data analysis, refer to “Data Analysis (A)
"Single waveform display (W)", "Superimposed waveform display (M)", "Grid map display (G)", "Equimagnetic field diagram (B)", "Time integration diagram (T)" , "Propagation time diagram (P)" and "magnetic field source display (S)" can be selected and executed. Further, data measurement can be executed by selecting a submenu of “measurement panel (P)” in the menu of “data measurement (Q)”. After the completion of steps 10, 11 and 12, the flow returns to step S-4. The details of the subject selection in step S-5, the averaging process in step S-10, the data analysis in step S-11, and the data analysis in step S-12 are described below with reference to FIGS. Will be described in more detail.

FIG. 17 shows a flow of subject selection in step S-5 in FIG. In the case of subject selection, the flow is branched into four according to menu selection or subject selection. One of the branches is a case where the subject selection is completed by designating and selecting the subject (S-5-1). According to another branch, a submenu of "Search (S)" of the menu of "List (L)" is selected. As a result, the search dialog box shown in FIG. 11 is opened (S-5-2), and the subject search condition is input using this dialog box (S-5-3). As a result, the subject is searched (S-
5-4) Based on this, the display contents of the subject list on the subject list screen shown in FIG. 24 are changed (S-5-5). According to yet another branch, a submenu "Release (X)" of the menu "List (L)" is selected. In this case, the selected subject is returned to the list of all subjects (S-5-6), and the display content of the subject list is changed (S-5-5). According to the remaining one of the branches, the "Registration (R)" submenu of the "List (L)" menu is selected. In this case, the subject registration dialog box shown in FIG. 10 is opened (S-5-7), and subject information is input (S-5-8). In these steps, the end of the input is determined until all the subjects have been input (S-5-9). When the input is completed, the subject list is updated (S-5). -5).

In this embodiment, a plurality of input data or operation instructions to be input are displayed by displaying a pull-down menu on the display screen, except for the character input such as the subject's name and address, and the selection target is selected from among the selection targets. An input operation is performed by pointing to the specific target with a mouse. As a result, most operations can be performed by mouse operation, so that a comfortable operation environment can be provided to an operator who is not accustomed to the keyboard, and the input / operation time can be reduced. As for the plurality of selection targets in the pull-down menu, selection targets that can be input / operated in this device or its input / operation state are set and displayed in advance, so that erroneous input / erroneous operation can be reduced. Further, in this embodiment, since the cursor can be put on the input area and input can be made via the keyboard, the degree of freedom of input by the operator is secured. Further, in this embodiment, it is assumed that characters are input using a keyboard, but it is also possible to display a dialog on the keyboard at the time of input and operate the mouse to input the dialog. Further, a handwriting input dialog may be displayed and handwriting input may be performed by operating the mouse. Further, a touch panel may be provided in the display unit, and input / operation may be performed on the screen via a fingertip or an input pen. Thus, the operability of input / operation can be remarkably improved.

FIG. 18 shows the flow of data measurement in step S-12 in FIG. First, a grid map of a magnetocardiogram waveform is displayed as an initial screen as shown in FIG. 25 (S-12-1). In the figure, in the operation area section, operations for channel selection, ON / OFF of the waveform monitor, lock / unlock of the FLL circuit 6, automatic adjustment of the offset voltage of the AFA 7, and heat flash can be respectively performed. , Signal sampling condition setting, waveform display scale setting, and AFA parameter setting. The channels consist of 64 8 × 8 channels, and you can select all channels by clicking the “Select All Channels” button or by dragging the channel matrix diagonally from end to end. Also, by selecting a channel matrix in row units or column units or dragging one of the items (hereinafter referred to as “channel items”), channels can be selected in row units or column units. In any case, based on the selected channel item, the magnetocardiogram waveform of the channel associated with the item is displayed on the analysis data display section. In the case of selection in units of rows or columns, the display is as shown in FIG. In this case, the selected waveform is enlarged and displayed on the full scale on the time axis. That is, when all 64 channels are selected, as shown in FIG. 25, the analysis data display section is divided into upper, lower, left, and right (cells) to give priority to the display of all the channels. In this case, as shown in FIG. 26, the analysis data portion is divided into upper and lower parts to form a familiar graph form in which the time axis is left and right, thereby giving a display form in which visibility is prioritized.

For waveform monitoring, when the "ON" button is pressed, for example, 0.5 sec.
The acquisition of the signal and the updating of the waveform are repeated at a specified time interval from c to 2 sec, and the magnetocardiographic signal of the subject is monitored. When the "OFF" button is pressed, the updating of the waveform is stopped. For FLL, use the “Lock” button or “Unlo
By clicking the "ck" button, the magnetic field lock can be performed on the 64 SQUID sensors, and the lock can be released. In this case, if one button is pressed, the state is maintained until the other button is pressed. As a result, a malfunction state that is not selected is avoided. Clicking the "AFA offset adjustment" button automatically adjusts the offset voltage. When the "heat flash" button is clicked, a heat flash operation dialog box shown in FIG. 14 is opened. Select the channel with the mouse or the arrow keys and click "OK".
When the button is clicked, a heat flash operation is executed for the SQUID of the selected channel. Clicking the “Cancel” button closes the dialog box and ends the process.

For the sampling time (measurement time) and interval, clicking a corresponding text box with an inverted triangle opens a pull-down menu of selectable numerical values, from which a desired number can be selected. The selectable numbers are, for example, 1 sec, 5 sec, 10 sec, 30 sec, 1 min and 2 min for time, and 0.1 msec, 0.5 msec, 1.0 msec, 2.0 msec, 4 for intervals. 0.0 msec, 5.0 msec and 10.0 msec. The time may be selected from about 1 sec to about 24 h as needed. "Time" in the "Scale" box is msec
The unit time scale, ie, the horizontal scale, and “signal” means the scale of the A / D converted signal, ie, the vertical scale. As for these, similarly to the selection of the sampling time and interval, a desired numerical value is selected from a pull-down menu opened by clicking the corresponding text box. The AFA parameters include an input gain I _gain , an output gain O _gain , a low-pass filter (LPF) frequency (reference frequency), a notch filter (BEF) frequency, and a high-pass filter frequency (reference frequency). Similarly, a desired number or character is selected from a pull-down menu opened by clicking the corresponding text box. The numbers or letters are, for example, 1, 2, 5, 5, 1 for I _gain
0, 20, 50, 100, 200, 500 and 1000, O _gain is, for example, 1, 10 and 100, and LPF is, for example, 30 Hz.
, 50 Hz, 80 Hz, 100 Hz, 200 Hz, 400 Hz and 1 kHz, Off for BEF, 50 Hz and 60 Hz, and for HPF, for example, 0.05 Hz, 0.1 Hz and Thru. It is. These may be input from the keyboard instead of selection.

As the channel, an auxiliary channel of, for example, 16 channels is prepared in addition to the 64 channels, and for example, an electrocardiographic waveform may be obtained in the auxiliary channel. The waveform of the tenth channel as a reference channel is displayed at the bottom of FIG. 25, which is the electrocardiographic waveform obtained on the tenth channel among the auxiliary channels. The magnetocardiogram waveform generally contains magnetic noise, while the electrocardiogram waveform does not contain such noise. Therefore, the displayed magnetocardiogram waveform is compared with the electrocardiogram waveform of the reference channel to obtain information as to whether the magnetocardiogram waveform contains magnetic noise. Of course, the electrocardiographic waveform may be obtained from any of the regular 64 channels instead of the auxiliary channel. Further, other than the electrocardiographic waveform, an electroencephalogram, a blood flow waveform, a blood pressure waveform, or the like may be used. Further, the electrocardiographic waveform of the pregnant woman may be compared with the magnetocardiographic waveform of the fetus. Further, as the reference waveform, not only a reference waveform of one channel but also a reference waveform of a plurality of channels may be displayed. Further, the reference channel may be used for inputting not only a signal from a living body but also various control signals for maintenance or the like.

Returning to the flow of FIG. 18, in step S-12-2, the monitor channel is selected in the manner described above (S-12-2), and when the lock button of the FLL is pressed, the magnetic fields of all SQUIDs are locked. (Step S-12-3). In that state,
The sampling time and the signal, which are the measurement parameters, are set, and the AFA parameters are set (step S-12-4). With respect to the setting, this setting can be omitted from the next time by using the set condition. As a result, it is not necessary to set the conditions every time, so that the setting time can be reduced. Note that the setting condition may be recorded by giving a name or the like so that the setting condition can be called. When the “start” button in the “measurement” box is pressed, measurement is started, “measurement in progress” is displayed, and a progress bar indicating the progress of measurement is displayed as shown in FIG. 15 (step S−). 12-5). In the progress bar of this embodiment, the bar extends from left to right in the form of a bar graph in accordance with the progress of the process. However, the entire process content (time) is set to, for example, 100, and the progress of the current process may be known. , A pie chart, etc. Further, the progress bar is displayed at a predetermined position on the measurement screen while leaving the measurement screen around. As a result, the contents of the display screen do not change significantly, and erroneous operations can be reduced.

When the measurement is started, the displayed signal waveform is fixed as it is, and a progress bar is displayed on the fixed display screen. Updating of the progress bar is repeated, for example, every second until the set time ends (S-12-6). "
Pressing the “Stop” button in the “Measure” box stops the measurement. When the measurement is completed, the screen shown in FIG. 26 is displayed, and the waveform is confirmed (S-12-7).
. Thereafter, the necessity of saving the data is determined (S-12-8), and if it is necessary, the menu "File (F)"-"Save (S)" is selected, and the signal is saved. The data is added to the data list of the subject (S-12-9). Thereafter, it is determined whether the measurement is necessary again, including the case where the storage is not necessary (S-12-10). If necessary, the above steps are repeated. If not, all the steps of the data measurement are completed. In this case, the menu is selected so that the screen is displayed as shown in FIG. FIG. 26 shows an example in which the channel in the second column is selected as the channel.

In FIG. 26, at the bottom of the analysis data section, there is a scroll bar 262 through which a scroll box 261 moves. The scroll box 261 is movable between the left and right ends of the scroll bar 262, and the width w of the scroll box represents a time scale. The time width between the left and right ends of the scroll bar 262 indicates the measurement time. Therefore, the displayed waveform is an enlarged waveform of a portion of the waveform generated during the measurement time corresponding to the time scale w of the scroll box 261. It is. This allows the operator to change the waveform currently displayed in the analysis data section to the measurement time (
The width of the scroll bar 262) indicates how long (the width of the scroll box 261), and the waveform can indicate the first half or the second half of the measurement time. , Visibility can be improved. Further, since the position of the scroll box 261 and the waveform of the analysis data section are linked, the cursor is moved to the scroll box 261 while being dragged, thereby moving the display area of the analysis data section for a predetermined time. May be viewed. By doing so, the scroll bar 262 can be treated as a table of contents, for example, the waveform of a predetermined time can be easily confirmed, and the measurement contents can be confirmed in detail.

FIG. 19 shows the flow of the averaging process in step S-10 in FIG. In the averaging process, in order to remove noise of each data measured in each channel, an addition is performed for each channel and an average value is calculated. The following processing is performed to set a reference time for the averaging processing of each channel, and the averaging processing of each channel is executed. First, raw data of the specified subject is read (S-10-1). This is performed by selecting a row in the list data of FIG. 24 in which "data type" is raw data. Thus, the magnetocardiogram waveform of the channel in the first column shown in FIG. 27 is displayed as an initial display (S-10-2). Next, a display channel is selected (S
-10-3). FIG. 27 shows an example in which the channel in the second column is selected. afterwards,
The setting channel is designated (S-10-4). This is performed by clicking the text box of “channel” in the “averaging condition” box in the operation area portion or by clicking the mouse on the area displaying the waveform of the desired channel. In this case, clicking the triangle button in the text box increases the channel number, and clicking the inverted triangle button decreases the channel number. FIG. 27 shows an example in which the specified channel is the channel in the second column and second row. By this channel designation, a channel serving as a reference time for the averaging process is specified. In specifying this channel, it is preferable to select a channel having the most typical or easy-to-understand waveform. If there is no channel having a good waveform in the selected row or column, it is possible to start over from the step (S-10-3) again.

When one channel in the analysis data display section is specified, a threshold cursor 271 is displayed at the position of the designated channel as shown in FIG. Thereby, the specified channel can be visually confirmed. In FIG. 27, three slider cursors 273 to 275 movable in the left and right directions are displayed above the analysis data display unit 805. These are automatically displayed at the same time when the display screen of FIG. 27 is displayed. Is done. In step S-10-5, a threshold value, an offset time, and an averaging time, which are averaging conditions, are set by clicking corresponding text boxes in the “averaging condition” box. Click the triangle button to increase the number, or click the inverted triangle button to decrease the number. The threshold is set by selecting a number representing the threshold in the "Threshold" text box. As a result, the threshold cursor 271 automatically moves to the position corresponding to the numeral. The moving position in that case can be clearly confirmed by the cursor line. The change (selection) of the number representing the threshold value in the “threshold value” text box and the movement of the threshold value cursor 271 are interlocked with each other. It is possible. The slider cursor 273 indicates the position (reference time) at which the rising portion of the waveform matches the threshold value set by the slider cursor 271, and the pointed position can be clearly confirmed by the cursor line. The slider cursor 273 moves following the reference point-in-time position so as to coincide with the reference point-in-time position that changes according to the change of the threshold value. When a number representing an offset time is selected in the “Offset” text box and a number representing the averaging time is selected in the “Time” text box, the slider cursors 274 and 275 move to the corresponding positions. The moving position in that case can be clearly confirmed by the cursor line of those slider cursors. The movement of the slider cursors 274 and 275 is linked to the selection of numbers in the “offset” and “time” text boxes. Therefore, the offset time and the averaging time can be set by moving the slider cursor.

In step S-10-6, whether the averaging should be performed automatically or manually as the averaging mode is set (S-10-7). Thereafter, when the "setting" button is clicked (S-10-8), the addition processing is performed. "
Click the "Cancel" button to cancel all averaging conditions. As addition processing, a time t (reference time) exceeding the threshold value is searched for in each channel (S-10-9), and a waveform is displayed centering on the time t (S-10-9).
That is, a waveform from t-50 msec to t + 50 msec is displayed so that the time point t is positioned at the center of the screen (S-10-10), and it is determined whether or not the cancel is selected in the manual mode (S-10). 10-11), unless cancellation is selected, waveform addition is executed (S-10-12).
Steps S-10-9 to S-10-12 are repeated for each channel by the number of additions, and the added data is divided by the number of additions (S-10-13), and averaged. The ending process ends. Thus, FIG.
In the display screen of the averaging process shown in FIG. 6, various conditions of the averaging process can be input / operated from both the operation area and the analysis data display unit 805. It is possible to provide the operator with various setting methods such as setting and setting detailed values in the operation area section, and to shorten the time for setting conditions. In particular, in this embodiment, a specific channel can be designated from a plurality of channels of the analysis data display unit 805 via a cursor and can be used as a reference channel for the averaging process, thereby reducing erroneous operations and improving operability. Is done. In addition, a threshold cursor or a slider cursor is displayed near the designated channel to enable visual recognition. Further, since the input / operation of various conditions of the averaging process can be performed with a threshold cursor or a slider cursor arranged near the channel, the movement of the operator's line of sight is reduced, and the visualization is performed in accordance with the waveform display. Since erroneous operations can be reduced, operability can be improved. These setting conditions, for example, the latest setting conditions may be stored and displayed as the next setting conditions, or each setting condition may be stored with a name and stored.

Another embodiment for performing the averaging process on the display screen of the averaging process shown in FIG. 27 will be described in detail with reference to FIGS. FIG. 35 shows a display screen of the averaging processing program. The display screens shown in FIGS. 35 to 42 show the analysis data section 805 and the operation area section 806 shown in FIG. 8 in detail. The screen is mainly divided into five object groups. When an object group is represented according to the procedure of the analysis process, the operation area portion includes a data read object 101, a graph display control object 102, an averaging object 103, an all channel summary display object 104, a file save and end object 105 And are arranged. An original waveform (a measured magnetic field waveform is referred to as an original waveform) display area 106 is arranged at an upper part of the display screen, and an averaging display area 107 is arranged at a lower part of the display screen. Hereinafter, embodiments of the operation method will be described according to the operation procedure.

An embodiment of file reading will be described with reference to FIG. When the button LOAD101a is pressed to read a file, a file selection dialog 108 is displayed, the icon is moved to the position of the file name to be selected, the file name is selected, and the file selection can be set. In this embodiment, the name is test1. The file with the dat name is selected, and is clearly displayed by the highlight 108a. To select all the files, select the Select All button 108b-1 of the selection buttons 108b, and all the files are highlighted and all the files can be selected. When a plurality of files are selected, a plurality of windows shown in FIG. 1 are displayed. After selecting one or more files as described above, the user presses the OK button 108b-2 to move to the next mode. If the file selection dialog 108 is opened by mistake, the user can select the Cancel button 108b-3 to return to the display screen shown in FIG. The number of data to be read in the selected file can be set by inputting a numerical value in the data point input window 101b. The sampling frequency of the data of the selected file is selected by the frequency toggle 101c. In this embodiment, a sampling frequency of 1 kHz is selected. If the method of manual selection as in the frequency toggle 101c is cumbersome, for example, information of the sampling frequency at the time of measurement may be recorded together with the measurement data in the selected file, and the sampling frequency may be automatically determined.

The graph display control will be described with reference to FIG. The waveform 106a displayed in the original waveform display area 106 in FIG. 37 is the test 1. dat file in Trig. The waveform of the channel selected by the ch button 102a (80 channels in this embodiment) is displayed. In this embodiment, in addition to the 64 magnetic sensors shown in FIG. 2, there are 16 channels of external inputs, and the second lead electrocardiogram measured simultaneously with the magnetocardiogram waveform on the 80th channel (see FIG. 43). (To be described later), and shows a display screen on which averaging processing has been performed using a waveform of an electrocardiogram. Of course, Trig. The channel selected by the channel button 102a is not limited to the electrocardiographic waveform of 80 channels, and any one of the magnetocardiogram waveforms shown in FIG. 6 can be selected. Dsp. The channel button 102b can select a channel (80 channels in this embodiment) displayed in the averaging display area 107. In the present embodiment, the channels selected in the original waveform display area 106 and the averaging display area 107 are the same, but need not necessarily be the same. The graph display area (time area width) of the original waveform display area 106 and the averaging display area 107 can be changed by inputting numerical values into the text box width 102c and the text box offset 102d.

A text box width 102c is a time width (unit: ms) displayed on the horizontal axes 106b and 107b of the original waveform display area 106 and the averaging display area 107.
) Can be set, and the text box offset 102d can set the time (in ms) to skip. For example, when reading the data width of 4000 ms by skipping 1000 ms from the data point at time 0 of the data, enter the numerical value of the text box offset102d as 1000 ms and the numerical value of the text box width102c as 4000 ms. In this embodiment, an example is shown in which the numerical value of the text box offset102d is input as 1 ms and the numerical value of the text box width 102c is input as 4000 ms. The ordinates of the original waveform display area 106 and the averaging display area 107 in the present embodiment are displayed with data values converted into digital data by the A / D converter. It may be displayed. Further, in this embodiment, the display width of the vertical axis is automatically scaled to a range in which the maximum value and the minimum value of the data within the time width selected in the display section can be displayed.

A method for setting the peak detection will be described with reference to FIG. The peak detection is performed by the averaging object 103. First, a numeral is input into the text box Threshold103a to set a peak detection threshold (180 in this embodiment). Next, a detection method is set by a toggle button Method 103b. The detection method is a method of detecting the maximum peak having a value exceeding the threshold (peak +, described in FIG. 38), and a method of detecting the minimum peak having a value smaller than the threshold (pe
ak-), a method of detecting a cross point with a threshold value when the value changes from a value smaller than the threshold value to a larger value (cross +), a method of detecting a cross point with the threshold value when the value changes from a value larger than the threshold value to a smaller value (Cross-) are prepared. In the present embodiment, the method (peak +) for detecting the maximum peak is selected. Further, the time width for averaging can be selected by entering a number in the text box FrameLength 103c. By inputting a number into the text box DataLength 103d, the time width before the detection peak can be set. Set contents (
103a, 103b, 103c, 103d), if you want to perform peak detection, press the button CALC. Press PEAK103e to perform calculation. As soon as the peak detection is completed, the values of the set FrameLength103c and DataLength103d are displayed on the original waveform 106a displayed on the original waveform display area 106 on the averaging display range display section B1, the averaging display range maximum time B2, and the averaging display range minimum. At time B3, the setting range is displayed on the original waveform 106a.

In addition, white circles C1, C2, C3, and C4 are all displayed at the peak points extracted in the waveform on the display screen. The number 1 is displayed on the circle C1 so that the number of the detected peak can be recognized. In this embodiment, the value of Frame Length 103c is set to 1400, and the value of Data Length 103d is set to 700. To perform averaging processing while confirming the original waveform 106a displayed on the original waveform display area 106, the averaging display range display section B1, the averaging display range maximum time B2, and the averaging display range minimum time B3 The averaging process is performed by pressing the button NEXT 103f, and the averaging result is displayed in the averaging display area 107 as an averaging waveform 107a. FIG. 38 shows an example in which the button NEXT 103f is pressed after observing the waveform of the circle C1 to perform the averaging process. The waveform is displayed. In the averaging process, the averaging process is performed on all the waveforms of the channels not displayed in the original waveform display area 106 or the averaging display area 107 being displayed. In FIG. 38, only one waveform is displayed in the original waveform display area 106 and only one waveform is displayed in the averaging display area 107. However, a plurality of waveforms are displayed in the original waveform display area 106 and the averaging display area 107, respectively. May be.

FIG. 39 shows a case where the second peak is not selected as the averaging data by pressing the button SKIP 103g. Further, FIG. 39 shows a case where the number in the text box width 102c for setting the waveform display time width, which was 4000 in FIG. 38, was changed to 8000 after pressing the button SKIP 103g. Accordingly, the averaging waveform 107a displayed in the averaging display area 107 is the same as the first waveform selected in FIG. If the user wants to interrupt the peak detection processing, by pressing the button CLEAR103h, the averaging waveform 107a displayed in the averaging display area 107 disappears, and nothing is displayed in the averaging display area 107. For the peak selected for the averaging process, the circle C1 is changed from a white circle to a black circle, and for the peak not selected for the averaging process, the mark is changed to a double circle. Of course, the shapes and colors of the circles are not limited to white, black, and circles. By leaving the averaging selection state of the peak point as a history as described above, it is possible to confirm again after the averaging process is completed. In addition, although not specified in the present embodiment, unnecessary after the entire process is completed. It is also possible to select and remove the peak averaging waveform.

FIG. 40 shows an embodiment in which the averaging process shown in FIG. 38 or 39 is continued and the same process is performed on the sixth detected peak. Since the text box Threshold103a is set to 180 and the toggle button Method103b is set to the method of detecting the maximum peak (peak +), the peaks beyond the sixth one are not detected because the peak value is below 180. Furthermore, when a peak is detected in the next time width, if the value of the text box offset102d is input as 8000, for example, the next 8000 ms to 16000 ms can be displayed and the same averaging process can be performed. Also, as described above, black circles C1, C3, C4, C5, and C6 among the circles C1 to C6 indicate peaks selected as the averaging process. C2 indicates one not selected for the averaging process.

FIG. 41 shows a waveform display 109 of the averaging processing result of all channels when the button View @ Average 104b in the all channel summary display object 104 is pressed. With this operation, the waveform 109a on which averaging processing has been performed for all channels can be displayed in accordance with the position of the sensor. Similarly, by pressing the button View @ Source 104a, the waveforms of all channels before processing can be displayed.

FIG. 42 illustrates the waveform file saving process after the averaging process. When saving the file after the averaging process, the user presses a button SAVE 105a to display a save dialog 110. After the display, if a new file name is to be created, the user can enter the file name in the text box 110a and press the OK button 110b to save the file under an arbitrary file name. When the user wants to overwrite the existing file, the user can highlight the file name to be used and press the button OK110b to save the averaging result as the same file. When the save dialog 110 is displayed by mistake or when the file is not saved, the user can return to the display screen shown in FIG. 41 without saving the file by pressing the button Cancel 110c. When all the processes have been completed, the averaging process application can be terminated by pressing the button QUIT 105b.

The above is the procedure and the screen display method when the averaging process is performed. When the above averaging process is performed, a suitable averaging process can be performed by performing the following preprocessing. If the waveform is fluctuating due to low-frequency magnetic field noise such as respiratory noise, the signal of one channel or the signals of all channels should be passed through a high-pass filter as preprocessing for averaging. . When only one channel has passed through the high-pass filter, it is also possible to perform peak detection from the signal that has passed through the high-pass filter, and apply the above-described averaging process to the signals of all channels from the peak detection result. As a type of filter used for the high-pass filter, for example, a digital filter such as an IIR (infinite impulse response) filter or an FIR (finite impulse response) filter may be used as the high-pass filter having a cutoff frequency in a range of 0.1 to 3 Hz. In the case where commercial power supply noise (for example, 50 Hz or 60 Hz) is a problem as noise and low frequency respiratory noise is a problem, a comb-shaped notch filter (removing an integer multiple of 50 Hz or 60 Hz) is removed. Filter). The comb-shaped notch filter refers to a notch filter having a bandwidth of about 1 Hz centered on a frequency such as 0 Hz, 50 Hz, 100 Hz, 150 Hz. When the above-described filter processing is used as preprocessing of the averaging processing, the averaging processing with less noise can be performed.

Next, a configuration for simultaneously measuring the magnetocardiogram and the electrocardiogram when the above averaging process is performed on the electrocardiogram will be described with reference to FIG. The electrocardiograph main body 121 is arranged outside the shield room to avoid magnetic noise. The wiring 122-1 of the electrocardiograph connected to the electrocardiograph main body 121 is inserted into the shield room, and a limb lead wire 122-2 is connected to the end of the electrocardiograph wiring 122-1. A carbon electrode 122-3 that does not easily generate magnetic noise is disposed at the end of the limb induction wire 122-2. In the present embodiment, the description has been made using the limb guide wire 122-2 and the carbon electrode 122-3, but the present invention is not limited to these. For example, a carbon electrode may be used for the chest guide wire (lead 12), The electrode portion may be formed using a magnetic material. Further, the electrocardiograph main body 121 may be arranged in a rack in which the FLL circuit 6 and the amplifier / filter / amplifier 7 are stored. The waveform of the electrocardiograph is stored as digital data on the computer 8 at the same time as the waveform of the magnetocardiogram, and an arbitrary number of magnetocardiogram or electrocardiogram waveforms can be displayed in real time simultaneously with the acquisition of the magnetocardiogram and electrocardiogram data. . The display part of the real-time waveform is not limited to the screen of one computer 8, but can be selectively displayed on a plurality of screens (such as a computer display or a television monitor) simultaneously inside and outside the shield room.

FIGS. 44A and 44B show two examples showing the relationship between the arrangement of the electrocardiograph main body 121 and the biomagnetic field measuring apparatus. FIG. 44 shows a positional relationship between the FLL circuit 6 and the amplifier / filter / amplifier 7 arranged outside the seal room 1 and the electrocardiograph main body 121 shown in the embodiment of the biomagnetic field measuring apparatus shown in FIG. . In the embodiment shown in FIG. 44A, the FLL circuit 6 and the amplifier / filter / amplifier 7 are built in the box 124 as one unit, and the FLL circuit 6 and the amplifier / filter / amplifier 7 Are turned on all at once. An electrocardiograph main body 121 is placed above the box 124, connected to the wiring 122-1 and introduced into the shield room. The wiring 122-1 and the wiring connected between the FLL circuit 6 and the cryostat 4 may be wired inside the shield room through the same hole provided in the wall of the shield room, or may be connected to the electrocardiograph. When magnetic noise due to electromagnetic waves or the like induced in the cable becomes a problem, the wiring connected to the wiring 122-1 and the wiring connected between the FLL circuit 6 and the cryostat 4 through different holes provided in the wall of the shield room. It may be wired separately inside the shield room. The electrocardiograph main body 121 is provided with a roll paper 123 for printing an electrocardiogram waveform. What is printed on the roll paper 123 is not limited to the waveform of the electrocardiogram, and the waveform of the electrocardiogram may be printed, or a roll paper unit dedicated to printing the electrocardiogram waveform may be installed in the box 124. In the embodiment of FIG. 44 (b), the FLL circuit 6, the amplifier / filter / amplifier 7, and the electrocardiograph main body 121 are built in the box 124 as one unit, and FIG. 4 shows a flow of data analysis. Data analysis is intended to display various types of waveforms and diagrams to obtain information necessary for diagnosis. Select the menu shown in Fig. 9 to select various types of waveforms and diagrams. Can be displayed. That is, "single waveform display (W)" of "data analysis (A)"
Is selected, the single waveform screen shown in FIG. 28 is displayed (S-11-2), and if "overlay waveform display (M)" of "data analysis (A)" is selected, the single waveform screen shown in FIG. The waveform screen is (
S-11-3) If "grid map display (G)" of "data analysis (A)" is selected, the grid map waveform screen shown in FIG. 30 is displayed (S-11-4) and "data analysis (A)". Is selected, the isomagnetic diagram screen shown in FIG. 31 is displayed (S-
11-5), if "Propagation time diagram (P)" of "Data analysis (A)" is selected, FIG.
Is shown in (S-11-6), and "Data analysis (A)"
When the "time integral diagram (T)" is selected, the isochronous integral diagram screen shown in FIG. 33 is displayed (S-11-
7) Each is displayed, and the “End of magnetocardiographic system (X
) "To end the system.

に お い て In each screen, if you click a radio button (circular button in the drawing) in the operation area, the screen of the waveform or diagram specified by the click is displayed instead. For this reason, in FIG. 20, the branch part is not "branch by menu" but "branch by menu or radio button". Therefore, according to this embodiment, various analysis data can be obtained only by clicking the radio button in the operation area without selecting the menu of FIG. 9, so that the operation time can be reduced, Erroneous operation can be reduced and operability can be improved.

28 to 30, the “magnetic flux density” in the “scale” box is a value of the full scale on the plus side and the minus side with reference to the zero level (the unit is picotesla (pT)), and the value thereof is Click the triangle button in the text box to open a pull-down menu. 28 to 33, the radio box in the "display component" box is clicked to select the waveform of the normal component or the waveform of the tangent component, and the screen can be displayed.

で は In FIG. 28, the waveform of each channel selected in the channel is displayed with the left end of the analysis data portion adjusted to the offset time. According to the analysis data, it is possible to compare the shapes and sizes of the waveforms of the respective channels arranged and displayed in the analysis data section in the vertical direction. Similarly, in FIG. 29, the waveforms arranged vertically in FIG. 28 are displayed in an overlapping manner, and the shapes and sizes of the waveforms can be compared. In FIG. 30, all the channels are displayed on the basis of the offset time as in FIGS. 28 and 29. Therefore, the operator can select and analyze the number of channels as needed.

In FIG. 31, a vertically elongated magnetic field strength index box 310 is arranged at the right end of the analysis data section. The magnetic field strength index box is divided into twelve sections having different colors. This is to improve the visual angle (color) recognizability by distinguishing the intensity range of the magnetic field indicated by each island pattern on the isomagnetic diagram screen shown in FIG. 31 by the type of color. That is, the center position 311 in the longitudinal direction of the magnetic field strength index box 310 is a position where the magnetic field strength is zero, and the sections above the center position are referred to as the first to sixth sections in order from the center position. Thus, for example, the first section has a magnetic field strength range of 0 to 2 pT, the second section has a magnetic field strength range of 2 to 4 pT, the third section has a magnetic field strength range of 4 to 6 pT, and the fourth section has a magnetic field strength range of 6 to 8 pT. The fifth section corresponds to a magnetic field strength range of 8 to 10 pT, and the sixth section corresponds to a magnetic field strength range of 10 to 12 pT. The same applies to the section below the center position. However, the section above the center position indicates the magnetic field strength in the plus direction, and the section below the center position indicates the magnetic field strength in the minus direction. The isomagnetic diagram shown in FIG. 31 is displayed in different colors according to the magnetic field strength in accordance with the definition of the correspondence between the magnetic field strength range and the color in the magnetic field strength index box 310. In addition, as a color, the plus side of the magnetic field strength may be a warm color system, the minus side may be a cool color system, and the center may be yellow. Thereby, the strength of the magnetic field can be recognized in color, so that the visibility can be improved. Moreover, according to this embodiment, since the magnetic field strength index box 310 is provided near the analysis data section, the color to be compared, that is, the color assigned to the map and the predetermined color of the magnetic field strength index box 310 are determined. Since it is possible to confirm the movement of the line of sight while comparing the movement without greatly moving the line of sight, it is possible to clearly determine the relationship between the level of the magnetic field and the color. In this embodiment, the magnetic field strength index box 310 is provided at the right end of the analysis data section, but may be located near the analysis data section, for example, at the upper, lower, or left side.

In FIG. 31, “number of maps” in the “reconstruction parameter” box indicates the number of displayed isomagnetic maps, “maximum value” indicates the magnetic field strength corresponding to both ends of the magnetic field strength index box 310, and “interval”. "Means a magnetic field range corresponding to the length of each section in the magnetic field strength index box 310. Its value can be selected by clicking the triangle or inverted triangle button in the corresponding text box. The ECG waveform of the reference channel and two map time selection cursors 311 and 312 are displayed at the bottom of the analysis data display section. A division line having the same interval is displayed between the two map time selection cursors 311 and 312, and the number of the lines matches the number of maps selected by the map number selection. Also, the two map time selection cursors 311 and 312 can move their positions independently in the left and right direction. When the movement changes the distance between the cursors, the space between the dividing lines also changes. Are always equally spaced. Of course, it is also possible to provide a cursor for each division line and to set them individually one by one. In FIG. 31, the number of displayed isomagnetic maps is 16, but these diagrams are the diagrams at the time when the dividing line on the electrocardiogram waveform is located. The time is also displayed so you can see when the map is up to date. Thus, as described with reference to FIG. 26, the operator can determine how much the map currently displayed on the analysis data display section (the width of the electrocardiographic waveform) (the two cursors 311 and 312), and it is possible to grasp at a glance where the range indicated by the map is within the analysis time, so that the visibility can be improved. Further, the range indicated by the map can be set by simply moving the two cursors with a mouse operation, so that the operation is easy. Furthermore, if the interval between the dividing lines is freely set, various analysis environments can be provided to the operator, for example, by denying a questionable part and sparsely setting other parts. Further, when a check mark is displayed by clicking a check box of “current direction” in the operation area, an arrow is displayed on the isomagnetic diagram. The isomagnetic map on which the arrow is displayed is called an arrow map (not shown). For the arrows, the position indicates the position of the channel (position of the magnetic sensor), the length indicates the strength of the magnetic field, and the direction indicates the direction of the current when the direction of the magnetic field is converted into the direction of the current.

FIG. 32 shows an equi-propagation time diagram. In this diagram, the starting position of the propagation time (time t1 in FIG. 7) can be changed by changing the position of the cursor 321 moving on the reference waveform. Yes, the position of the cursor 321 can be changed by dragging the cursor using a mouse.

FIG. 33 shows two time integration diagrams and one difference diagram. "Difference display" of the isochronous integration diagram can be easily displayed by clicking a check box and displaying a check mark. When “Difference display” is checked, four cursors 3 appear on the reference waveform.
31 to 334 appear, and two isochronous integration diagrams are displayed on the upper left and right sides, and a difference diagram is displayed on the lower left side, as shown. The two isochronous integration diagrams are based on the values obtained by integrating the magnetocardiogram waveform over the time ranges of 100 msec to 140 msec and 180 msec to 240 msec set using the cursors 331 and 332 and the cursors 333 and 334 on the reference waveform, respectively. The respective time ranges can be changed by dragging the cursors 331 and 332 and the cursors 333 and 334 with a mouse, respectively. The difference diagram represents the difference between the two time integral diagrams. If there is no check mark, only two cursors (for example, cursors 331 and 332) appear for the cursor, and only one isochronous integration diagram is displayed for the time integration diagram. Of course, the integration time can be changed by changing the position of the cursor. As described above, according to this embodiment, the user clicks the check box for "differential display" and displays two sets of cursors for prompting the next operation. Moreover, since the time range can be easily set by moving the two sets of cursors with a mouse, the operability can be improved.

FIG. 21 shows a flow of system adjustment. The menu selection causes the flow to branch into five (S-15). In this case, the currently displayed data is stored as it is (S-13), and the Φ-V characteristic curve shown in FIG. 34 is displayed (S-14).
. When “Fully automatic adjustment (A)” of “Data measurement (Q)” is selected, the adjustment values of I _bias and V _OFF are automatically calculated for the specified channel (S−
16) (The automatic calculation will be described later), the calculated adjustment value is set in the FLL circuit (S-17), and the flow returns to step S-14. "V" of "Data measurement (Q)"
_{If "OFF} adjustment (V)" is selected, V _OFF is calculated for the specified channel (S-18) (the calculation of V _OFF will be described later), and then the flow proceeds to step S-17 described above. . When "manual adjustment (M)" of "data measurement (Q)" is selected, a manual adjustment dialog box shown in FIG. 12 is opened (S-19). When the operator inputs the adjustment values of I _bias and V _OFF for each channel, the input adjustment values are accepted (S-20), and the adjustment values are inputted by pressing the “OK” button in the dialog box, and the FLL circuit is operated. (S-21). The dialog box is thereby closed (S-22), and the flow proceeds to step S-17. When "Adjustment value file (F)" of "Data measurement (Q)" is selected, the flow is further branched into two by a sub pull-down menu (S-22). That is, "Open (O)" is selected from the sub pull-down menu to inquire the file name to the operator, and the operator inputs the file name including the contents of FIG. 11 (S-23). The contents of the adjustment value file are set in the FLL circuit (S-24). Also, "Data measurement (Q)"-"Adjustment value file (F)"-"
"Overwrite save" or "Save as (A)" is selected to perform the same operation as in step S-23 (S-25), and the adjustment value can be written to the adjustment value file (S- 26).

FIG. 22 shows the flow of the automatic calculation in step S-15 in FIG.

$ S-15-1: In the case of fully automatic adjustment, the following processing is performed for all SQUID channels one by one. The channel being processed is assumed to be ch.

S-15-2: The calculated bias current and offset voltage are I _BIAS and V _OF
It shall be stored in a memory named _F. I _BIAS and V _OFF can hold the number of channel values, and all initial value 0. The temporarily stored amplitude of the Φ-V characteristic curve is ΔV.

S-15-3: For each channel ch, change the bias current _Ib from 0 to FIG.
"Scan parameters" changes in steps of [Delta] I _bias to the specified I _bias box (scanning) is, [Phi-V characteristic curve of the amplitude ΔV optimum channel ch most larger I _bias is the bias current I _BIAS (ch of ).

S-15-4~8: between the bias current 0 to I _b, the amplitude ΔV of [Phi-V characteristic curve can be determined by the following process. The external magnetic field Φ applied to the SQUID of the channel ch is changed (scanned) from 0 to Φext specified in the “scanning parameter” box in FIG. 34 in steps of ΔΦ, and the A / D converted signal is stored. determining the maximum value M _max and the minimum value V _min of the signal Te.

S-15-9~10: Here, the maximum value M if the difference between the _max and the minimum value V _min is greater than ΔV values of I _BIAS (ch) at I _bias, VOFF (ch) the maximum value M _max values of and the average of the minimum value V _min, respectively as the ΔV in the difference between the maximum value V _max and the minimum value V _min. If Trip ΔV holds the previous value is greater than the difference between the maximum value M _max and the minimum value V _min.

S-15-11: above processing bias current I _b is I _BIAS when repeated until the _{I bias (ch), V OFF} (ch) is the optimum bias current and offset voltage of the SQUID channel ch.

$ S-15-12: The above process is executed for all SQUID channels, and the full automatic adjustment ends.

FIG. 23 shows a VOFF adjustment flow in step 18 of FIG.

S-18-1: In the case of VOFF adjustment, the following processing is performed for all SQUID channels one by one.

S-18-2~6: by changing the external magnetic field [Phi given to the channel ch SQUID from 0 by "scanning parameters" ΔΦ steps until [Phi _ext specified in box 34 (scanned by) go, A / maximum value of D converted signal V _max and the minimum value V _m
Find the difference between in.

S-18-7: Optimal offset voltage VOFF of SQUID channel ch (
ch) is calculated as the difference between the maximum value V _max and the minimum value V _min.
S-18-8: The above processing is executed for all SQUID channels, and V _{OF
The F} adjustment ends. In the above description, “scanning of the external magnetic field Φ” can be realized by giving a signal obtained by D / A conversion of a value set inside the computer to the SQUID sensor.

FIG. 1 is a schematic configuration diagram of an embodiment of a biomagnetic field measurement apparatus according to the present invention. FIG. 2 is a perspective view showing an arrangement configuration of a magnetic sensor used in the biomagnetic field measurement device of FIG. 1. FIG. 2 is a perspective view of a single magnetic sensor that detects a normal component of a magnetic field and is used in the biomagnetic field measuring apparatus of FIG. 1. FIG. 2 is a perspective view of a single magnetic sensor that detects a normal component of a magnetic field and is used in the biomagnetic field measuring apparatus of FIG. 1. FIG. 2 is a diagram illustrating a positional relationship between a magnetic sensor and a chest of a subject in the biomagnetic field measuring apparatus in FIG. 1. FIG. 2 is a time waveform diagram of each component of a healthy person's biomagnetic field (cardiac magnetic field) measured by each magnetic sensor in the biomagnetic field measurement apparatus of FIG. 1. FIG. 2 is a diagram showing a time waveform of a tangential component of a magnetocardiogram of two specific channels measured on a healthy person in the biomagnetic field measuring apparatus of FIG. FIG. 2 is a diagram showing a basic layout of a display screen displayed on a display unit in the biomagnetic field measurement device of FIG. 1. FIG. 2 is a diagram showing an operation menu in a menu bar section of a display screen displayed on a display unit in the biomagnetic field measurement device of FIG. 1. In the biomagnetic field measuring apparatus of FIG. 1, a subject registration dialog box opened when "list (L)"-"registration (R)" is selected as an operation menu in a display screen displayed on the display unit. The figure which shows the content. In the biomagnetic field measuring apparatus of FIG. 1, the contents of a search dialog box opened when "list (L)"-"search (S)" is selected as an operation menu in a display screen displayed on the display unit. FIG. In the biomagnetic field measurement apparatus of FIG. 1, a manual adjustment dialog box is opened when "data measurement (Q)"-"manual adjustment (M)" is selected as an operation menu on a display screen displayed on the display unit. The figure which shows the content. In the biomagnetic field measurement apparatus shown in FIG. 1, an automatic diagnosis dialog box opened when "data measurement (Q)"-"measurement panel (P)" is selected as an operation menu on a display screen displayed on the display unit. The figure which shows the content. FIG. 2 is a diagram showing the contents of a heat flash operation dialog box that is opened when the “heat flash” button is pressed when the display screen of FIG. 25 or FIG. 26 is displayed on the display unit in the biomagnetic field measurement apparatus of FIG. . FIG. 2 is a diagram showing a measurement progress bar displayed on a display unit during measurement in the biomagnetic field measurement device of FIG. 1. FIG. 2 is a diagram showing a flow of an overall operation performed in the biomagnetic field measurement apparatus in FIG. 1. The figure which shows the flow of a subject selection in the subject selection step in the operation flow of FIG. FIG. 17 is a diagram showing a flow of data measurement in a data measurement step in the operation flow of FIG. 16. FIG. 17 is a diagram illustrating a flow of an averaging process in an averaging process step in the operation flow in FIG. 16. FIG. 17 is a diagram showing a flow of data analysis in a data analysis step in the operation flow of FIG. 16. FIG. 2 is a diagram showing a flow of system adjustment performed in the biomagnetic field measurement apparatus of FIG. 1. FIG. 22 is a diagram showing a flow of automatic calculation in an automatic calculation step in the system adjustment flow of FIG. 21. FIG. 22 is a diagram showing a VOFF adjustment flow in a VOFF adjustment step in the system adjustment flow of FIG. 21. FIG. 2 is a diagram showing a subject list screen displayed on a display unit of the biomagnetic field measurement device in FIG. 1. FIG. 2 is a diagram illustrating a data measurement screen displayed on a display unit of the biomagnetic field measurement device in FIG. 1. FIG. 2 is a diagram showing a waveform confirmation screen displayed when measurement is completed on a display unit of the biomagnetic field measurement device in FIG. 1. FIG. 2 is a diagram showing an averaging screen displayed on a display unit of the biomagnetic field measurement apparatus in FIG. 1. FIG. 2 is a diagram showing a single waveform display screen displayed on a display unit of the biomagnetic field measurement device in FIG. 1. FIG. 2 is a diagram showing a superimposed waveform display screen displayed on a display unit of the biomagnetic field measurement device in FIG. 1. FIG. 2 is a diagram showing a grid map display screen displayed on a display unit of the biomagnetic field measurement device in FIG. 1. FIG. 2 is a diagram showing an isomagnetic diagram display screen displayed on a display unit of the biomagnetic field measuring apparatus in FIG. 1. FIG. 2 is a diagram showing a propagation time diagram display screen displayed on a display unit of the biomagnetic field measurement apparatus in FIG. 1. FIG. 2 is a diagram showing a time integration diagram display screen displayed on a display unit of the biomagnetic field measurement apparatus in FIG. 1. FIG. 2 is a diagram showing a system adjustment screen displayed on a display unit of the biomagnetic field measurement device in FIG. 1. FIG. 2 is a diagram illustrating an initial screen of an averaging screen displayed on a display unit of the biomagnetic field measurement apparatus of FIG. 1. FIG. 2 is a view showing a file selection screen of an averaging screen displayed on a display unit of the biomagnetic field measurement apparatus of FIG. 1. FIG. 2 is a view showing a raw waveform display screen of an averaging screen displayed on a display unit of the biomagnetic field measurement apparatus of FIG. 1. FIG. 2 is a diagram showing an averaging process setting screen of an averaging screen displayed on a display unit of the biomagnetic field measurement apparatus in FIG. 1. FIG. 2 is a view showing a screen during an averaging process of an averaging screen displayed on a display unit of the biomagnetic field measurement apparatus in FIG. 1. FIG. 2 is a view showing a screen during an averaging process of an averaging screen displayed on a display unit of the biomagnetic field measurement apparatus in FIG. 1. FIG. 2 is a diagram illustrating an entire waveform display screen of an averaging screen displayed on a display unit of the biomagnetic field measurement apparatus of FIG. 1. FIG. 2 is a view showing a file saving processing screen of an averaging screen displayed on a display unit of the biomagnetic field measuring apparatus of FIG. 1. The figure which shows arrangement | positioning and connection of the electrocardiograph of the biomagnetic field measuring apparatus of FIG. The figure which shows the arrangement | positioning of the electrocardiograph of the biomagnetic field measuring apparatus of FIG.

Explanation of reference numerals

DESCRIPTION OF SYMBOLS 1 ... Magnetic shield room, 2 ... Examinee, 3 ... Bed, 4 ... Dewar, 5 ... Automatic replenishment apparatus, 6 ... FLL circuit, 7 ... Amplifier / filter / amplifier, 8 ... Computer, 8-1 ... Display part, 8-2: Keyboard, 8-3: Mouse, 20-1 to 20-8, 21-1 to 21-8, 22-1 to 22-8, 23-1 to 23-8, 24-1 to 24- 8, 25-1 to 25-8, 26-1 to 26-8 and 27-1 to 27-8 ... magnetic sensors, 10, 10 'and 10 "and 11, 11' and 11" ... coils, 12, 12 'And 12 "SQUID, 13 and 14 Sensor, 30 Chest, 261 Scroll Box, 262 Scroll Bar, 271 Threshold Cursor, 273 to 275 Slider Cursor, 311, 312 and 331 to 334 Cursor , 801 ... ta Tolbar section, 802 Menu bar section, 803 Toolbar section, 804 Subject information section, 805 Analysis data section, 806 Operation area section, 808 Status bar section, 807-1 Message bar section, 807- 2, date and time display section, 808 to 814, icon, 101, data read object, 101a, button LOAD, 101b, data point input window, 101c, frequency toggle, 102, graph display control object, 102a, Trig.ch button, 102b ... Dsp.ch button, 102c ... text box width, 102d ... text box offset, 103 ... averaging object, 103a ... text box Threshold
, 103b ... Toggle button Method, 103c ... text box FrameLength, 103d ... text box DataLength, 103e
Button Calc. Peak, 103f ... button NEXT, 103g ... button SKIP, 103h ... button CLEAR, 104 ... object for displaying an overview of all channels, 104a ... button View Source, 104b ... button View
Average, 105: File save and end object, 105a: Button SAVE, 105b: Button QUIT, 106: Original waveform display area, 106a: Original waveform, 106b: Horizontal axis, 107: Average display area, 107a: Average waveform, 107b horizontal axis, 108 file selection dialog, 108a highlight, 108b select button, 108b-1 Select All button, 108b-2 OK button, 108b-3 Cancel button, 109 waveform display, 109a ... Waveform, 110: Save dialog, 110a: Text box, 110b: Button OK, 110c: Button Cancel, 120: Gantry, 121: Electrocardiograph main body, 122-1: Electrocardiograph wiring, 122-2: Limb lead Electric wire, 122-3 ... Carbon electrode, 123 ... roll paper, 124 ... box, 125 ... power switch, B1 ... averaging range display section, B2 ... averaging display range maximum time, B3 ... averaging display range minimum time, C1, C2, C3, C4 , C5, C6 ... circles.

Claims (8)

A plurality of magnetic sensors for measuring a magnetic field emanating from the heart of a living body, a computer for processing a measured magnetic field waveform, and display means for displaying the processing by the computer; In the waveform, the time when the rising part of the QRS wave in the systole of the heart matches the threshold value, the time when the falling part of the QRS wave matches the threshold value, or the peak position time of the QRS wave is used as a reference. Then, the measured magnetic field waveforms are traced back from the time point by a predetermined time (t _off ), and from the time point t ₁ to the predetermined time point t ₂ beyond the QRS wave, are compared with the respective magnetic sensors. determined for the channel corresponding to, seek, etc. propagation time diagram connecting points are equal propagation time to the peak position point of the QRS wave from the time point t _1, to display the like propagation time diagram on said display means Biomagnetic field measuring apparatus characterized by. A plurality of magnetic sensors for measuring a magnetic field emanating from the heart of a living body, a computer for processing a measured magnetic field waveform, and display means for displaying the processing by the computer; In the waveform, the time when the rising part of the QRS wave in the systole of the heart matches the threshold value, the time when the falling part of the QRS wave matches the threshold value, or the peak position time of the QRS wave is used as a reference. Then, the measured magnetic field waveforms are traced back from the time point by a predetermined time (t _off ), and from the time point t ₁ to the predetermined time point t ₂ beyond the QRS wave, are compared with the respective magnetic sensors. , And for each channel, the measured magnetic field waveform is integrated over a predetermined time to obtain a time integrated value, and an isochronous product connecting points having the same time integrated value is obtained. Figure look, the equal time integral diagram biomagnetic field measuring apparatus and displaying to the display means. A plurality of magnetic sensors for measuring a magnetic field emanating from the heart of a living body, a computer for processing a measured magnetic field waveform, and display means for displaying the processing by the computer; In the waveform, the time when the rising part of the QRS wave in the systole of the heart matches the threshold value, the time when the falling part of the QRS wave matches the threshold value, or the peak position time of the QRS wave is used as a reference. Then, the measured magnetic field waveforms are traced back from the time point by a predetermined time (t _off ), and from the time point t ₁ traversed to the predetermined time point t ₂ beyond the QRS wave. And obtaining the isomagnetic map connecting the equal points of the measured magnetic field waveforms for each of the channels, and displaying the isomagnetic map on the display means. Measuring device. A plurality of magnetic sensors for measuring a magnetic field generated from the heart of a living body, a computer for processing the measured magnetic field waveform, and display means for displaying the processing by the computer; In the addition process in the averaging process of the measured magnetic field waveform of the corresponding channel, a process of searching for a time t exceeding a set threshold value is performed, and the measurement is performed around the time t. A biomagnetic field measuring device, wherein the displayed magnetic field waveform is displayed on the display means. A plurality of magnetic sensors for measuring a magnetic field generated from the heart of a living body, a computer for processing the measured magnetic field waveform, and display means for displaying the processing by the computer; In the addition in the averaging process of the measured magnetic field waveform of the corresponding channel, a process of searching for a time t exceeding a set threshold value is performed, and when the cancellation of addition is not selected by the operator. A biomagnetic field measuring apparatus, wherein the measured magnetic field waveforms are added, and the measured magnetic field waveforms are displayed on the display means around the time t. An electrocardiograph for measuring a current generated from the heart of a living body, a plurality of magnetic sensors for measuring a magnetic field generated from the heart, and an electrocardiographic waveform measured by the electrocardiograph and a magnetic field waveform measured by the electrocardiograph to perform processing A biomagnetic field measuring apparatus, comprising: a computer; and display means for displaying a processing result by the computer, wherein the magnetic field waveform and the electrocardiographic waveform measured simultaneously are displayed side by side on the display means. . A plurality of magnetic sensors for measuring a magnetic field generated from the heart of the living body inside the shielded room, a main body of an electrocardiograph arranged outside the shielded room, and the plurality of magnetic sensors arranged outside the shielded room. A driving circuit unit for driving, an electrode formed of a non-magnetic member disposed on the body surface of the living body, and a member for electrically connecting the main body of the electrocardiograph and the electrode. Characteristic biomagnetic field measurement device. 8. The biomagnetic field measuring apparatus according to claim 7, wherein a main body of the electrocardiograph is arranged above or inside the drive circuit unit.

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