JP2004001898A - Press-through package - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a press-through package which is transparent and has no failure such as void, fish eye, curl, twist, waviness and unevenness of thickness, can sufficiently protect an article to be packaged from moisture even under high temperature and high humidity, and exhibits good adhesion of a metal foil at a pocket part, and from which the article to be packaged can easily be taken out. <P>SOLUTION: The press-through package is provided by storing the article to be packaged in a storing pocket of a sheet provided with the storing pocket with a thickness of 50-500 μm by a vacuum forming process, comprising a thermoplastic norbornene resin, especially preferably a hydrogenated dicyclopentadiene ring-opened polymer, and with a thickness of 100-500 μm except the storing pocket, and closing the opening part of the pocket with a metal foil with a thickness of 10-60 μm to package the article to be packaged. <P>COPYRIGHT: (C)2004,JPO

Description

The present invention relates to a press-through package, and more particularly, it is colorless and transparent, has no defects such as voids, fish eyes, curls, twists, wavy waves, uneven thickness, etc. The present invention relates to a press-through package which can be moisture-proof, has good adhesion of a metal foil in a pocket portion, and can easily take out an object to be packaged.

The synthetic resin sheet, which is the base material of the press-through package (hereinafter referred to as PTP), is preferably transparent so that the package can be easily seen from the pocket portion, and prevents deterioration of the package due to moisture. Therefore, a material having a small moisture permeability is preferable. Conventionally, a product made of polyvinyl chloride or polypropylene, and in particular, a PTP that requires moisture-proof properties, a laminated sheet of polypropylene and polyvinylidene fluoride has been used. Was.

However, polyvinyl chloride has a problem that the moisture permeability is not small enough to package chemicals that are easily degraded by moisture, and it is difficult to incinerate after use. On the other hand, polypropylene is not good in vacuum formability, and when providing a pocket opening in a sheet by vacuum forming, the thickness of the pocket tends to be uneven, and the molded sheet is easily curled, and workability is poor. There was a problem. In addition, in the case of a laminated sheet of polypropylene and polyvinylidene fluoride, there is a problem that in addition to vacuum formability and workability, incineration is difficult.

The present inventors use a thermoplastic norbornene-based resin sheet as the base material of the PTP, make the pocket portion and the like have a specific thickness, and make the closing sheet a metal foil of a specific thickness, so that the moisture permeability is small and the incineration is small. It has been found that a PTP that is easy to process, has no defects such as voids, fish eyes, and curls when a pocket opening is formed by vacuum forming, and that allows easy removal of a packaged object is obtained. Was.

Thus, according to the present invention, after storing an article to be packaged in a storage pocket provided in a sheet made of a thermoplastic norbornene resin having the following thickness, the pocket opening of the sheet is made of a metal foil having a thickness of 10 to 60 μm. To provide a press-through package in which an object to be packaged is closed.
The thickness of the storage pocket portion is 50 to 500 μm, and the thickness other than the storage pocket portion is 100 to 500 μm.

The PTP of the present invention is colorless and transparent, free from defects such as voids, fish eyes, curls, twists, wavy waves, and uneven thickness, and can sufficiently protect the packaged object even under high temperature and high humidity. Good adhesion of foil and easy removal of packaged items.

(Thermoplastic norbornene resin)
The thermoplastic norbornene resins of the present invention are disclosed in JP-A-51-80400, JP-A-60-26024, JP-A-1-168725, JP-A-1-190726, and JP-A-3-14882. JP-A-3-122137, JP-A-4-63807, and the like. Specific examples thereof include a ring-opened polymer of a norbornene-based monomer, a hydrogenated product thereof, and a norbornene-based monomer. Addition polymers, addition polymers of norbornene monomers and olefins, and the like.

Norbornene-based monomers are also monomers known in the above publications, JP-A-2-227424, JP-A-2-276842 and the like, and include, for example, norbornene, its alkyl, alkylidene, aromatic-substituted derivatives and Polar groups such as halogen, hydroxyl, ester, alkoxy, cyano, amide, imide, and silyl of these substituted or unsubstituted olefins, for example, 2-norbornene, 5-methyl-2-norbornene, 5,5-dimethyl-2-norbornene, 5-ethyl-2-norbornene, 5-butyl-2-norbornene, 5-ethylidene-2-norbornene, 5-methoxycarbonyl-2-norbornene, 5-cyano-2-norbornene , 5-methyl-5-methoxycarbonyl-2-norbornene, 5-phenyl-2-norbo Nene, 5-phenyl-5-methyl-2-norbornene, 5-hexyl-2-norbornene, 5-octyl-2-norbornene, 5-octadecyl-2-norbornene and the like; a unit obtained by adding one or more cyclopentadiene to norbornene , Its derivatives and substituents as described above, for example, 1,4: 5,8-dimethano-1,2,3,4,4a, 5,8,8a-2,3-cyclopentadienoocta Hydronaphthalene, 6-methyl-1,4: 5,8-dimethano-1,4,4a, 5,6,7,8,8a-octahydronaphthalene, 1,4: 5,10: 6,9-trimethano -1,2,3,4,4a, 5,5a, 6,9,9a, 10,10a-dodecahydro-2,3-cyclopentadienoanthracene; etc .; a monocyclic compound having a polycyclic structure which is a multimer of cyclopentadiene Mers, Derivatives and substituents similar to the above, for example, dicyclopentadiene (hereinafter, referred to as DCP), 2,3-dihydrodicyclopentadiene and the like; adducts of cyclopentadiene with tetrahydroindene, etc .; Substitutes, for example, 1,4-methano-1,4,4a, 4b, 5,8,8a, 9a-octahydrofluorene, 5,8-methano-1,2,3,4,4a, 5,8 , 8a-octahydro-2,3-cyclopentadienonaphthalene and the like.

In the present invention, when a norbornene-based monomer is polymerized, other copolymerizable cycloolefins or the like may be used in combination within a range that does not substantially hinder the effects of the present invention to form a copolymer. Can be. Specific examples of the copolymerizable cycloolefin in the case of ring-opening polymerization include, for example, compounds having at least one reactive double bond such as cyclopentene and cyclooctene.

The polymerization of the norbornene-based monomer may be performed by a known method. Generally, a transition metal compound such as TiCl ₄ , WCl ₆ , MoCl ₅ , VCl ₅ , NiCl ₂ , or PdCl ₂ is used as a polymerization catalyst, and Al, Li, Na, Polymerization is performed by combining an alkyl compound of a typical metal such as Mg. Further, if necessary, a hydrogenated thermoplastic norbornene resin can be obtained by hydrogenation using a known method, for example, using Ni, Pd or the like as a catalyst.

In addition, in the conventionally well-known polymerization method, the transition metal derived from the polymerization catalyst remains in the polymer. When the PTP package is a medicine or food, it is not preferable that the transition metal remaining in the resin elutes, and it is preferable that the transition metal does not substantially remain in the resin. To that end, pore volume 0.5 cm ³ / g or more, preferably 0.7 cm ³ / g or more, preferably in the adsorbent such as a specific surface area of 250 meters ² / g or more alumina, a hydrogenation catalyst metal such as nickel Hydrogenation of the polymer using a supported heterogeneous catalyst, treatment of the resin solution with such an adsorbent to adsorb metal atoms, washing of the resin solution repeatedly with acidic water and pure water, etc. For example, the transition atom derived from the polymerization catalyst is reduced to 1 ppm or less.

The method for producing the heterogeneous catalyst may be in accordance with a known method, and is known in JP-B-50-15474, JP-B-49-32187, JP-B-49-111212, JP-B-51-48479, and the like. According to the method described above, the adsorption capacity of the carrier may be controlled by the conditions of drying and baking. For example, in the case of a heterogeneous catalyst in which nickel is supported on activated alumina, aluminum hydroxide powder is suspended in an aqueous solution of nickel sulfate or nickel nitrate at a concentration of 10 to 20% at a concentration of 10 to 20%, and hydrolyzed with sodium hydroxide. Thereby, nickel hydroxide is supported on the surface of the aluminum hydroxide. The powder is collected by filtration, solidified by extrusion, calcined at 350-450 ° C., contacted with hydrogen at 100-200 ° C. to reduce the surface, and further heated to 80-120 ° C. in the presence of oxygen. By oxidizing the metal surface to form an oxide film, a nickel catalyst supported on activated alumina can be obtained. Although the surface of nickel is covered with nickel oxide, nickel oxide becomes nickel by reduction in a hydrogenation reaction system and functions as a catalyst.

Extrusion conditions, the temperature and pressure, etc. of the firing, since the fine structure of the activated alumina is changed, the pore volume of 0.5 cm ³ / g or more, preferably 0.7 cm ³ / g or more, and preferably a specific surface area 250m Select the condition so that it is ² / g or more. Furthermore, when hydrogenation is performed at a high temperature, the thicker the oxide film, the higher the heat resistance. Therefore, the preferable conditions may be selected by adjusting the oxidation temperature, time, oxygen concentration, and the like. The thus obtained calcined product can be pulverized to obtain a heterogeneous catalyst.

(4) When a transition metal chloride is used as a transition metal compound of a general polymerization catalyst, 2 ppm or more of chlorine atoms usually remain. It is preferable that the chlorine atom does not remain in the medical device like the transition metal atom, and it is preferable that the chlorine atom is removed. The removal method can be performed by the same treatment as that for the transition metal atoms, and the residual amount can be reduced to 1 ppm or less.

The number average molecular weight of the thermoplastic norbornene resin used in the present invention is 10,000 to 200,000, preferably 15,000, in terms of polystyrene measured by GPC (gel permeation chromatography) using a toluene solvent. １００100,000, more preferably 20,000２０50,000. Further, when the thermoplastic norbornene-based resin has an unsaturated bond in the molecular structure, it can be converted into a thermoplastic saturated norbornene-based resin by hydrogenation. In the case of hydrogenation, the hydrogenation rate is 90% or more, preferably 95% or more, more preferably 99% or more, from the viewpoint of heat deterioration resistance and light deterioration resistance.

Among the thermoplastic norbornene-based resins, a thermoplastic saturated norbornene-based resin having excellent heat deterioration resistance and light deterioration resistance is preferable, and a norbornene-based ring-opening polymer hydrogenated product having excellent moldability is more preferable, and has excellent moisture resistance. Further, a hydrogenated DCP-based ring-opening polymer is more preferable. DCP ring-opening polymer hydrogenated products include DCP, its alkyl, alkylidene, aromatic-substituted derivatives and their polar groups such as halogen, hydroxyl, ester, alkoxy, cyano, amide, imide, and silyl groups. It is obtained by hydrogenating a polymer containing 50% by weight or more, preferably 60% by weight or more of a ring-opening repeating structural unit derived from a DCP-based monomer such as a substituted product. The greater the number of ring-opening repeating structural units derived from the DCP monomer, the better the moisture resistance. Further, from the viewpoint of moisture resistance, among the hydrogenated DCP-based ring-opening polymers, those containing no polar group are particularly preferable, and the DCP-based monomer-opened homopolymer hydrogenated product having no polar group, or Group-free DCP monomer and norbornene, 1,4: 5,8-dimethano-1,2,3,4,4a, 5,8,8a-octahydronaphthalene or their alkyl, alkylidene, aromatic Most preferred are ring-opened copolymer hydrogenated substituted derivatives.

{Circle around (5)} In terms of moisture resistance and vacuum moldability, the glass transition temperature (hereinafter, referred to as Tg) is 50 to 160 ° C, preferably 60 to 140 ° C, and more preferably 70 to 110 ° C. If the Tg is too low, the moisture permeability becomes high, and if the Tg is too high, the vacuum forming temperature becomes high, so that vacuum forming becomes difficult, and the formed sheet tends to be curled or wavy.

The thermoplastic norbornene-based resin used in the present invention may optionally include a phenol-based or phosphorus-based antioxidant; a phenol-based thermal degradation inhibitor; a benzophenone-based ultraviolet absorber; an amine-based antistatic agent. Lubricants such as esters of aliphatic alcohols, partial ester portions of polyhydric alcohols and partial ethers, and the like. As long as the object of the present invention is not impaired, other resins, rubbery polymers and the like can be mixed and used. Further, the thermoplastic norbornene-based resin sheet used in the present invention is generally preferable to have higher transparency so that the packaged object can be seen from the outside, but the packaged object is deteriorated by visible light. In this case, it is preferable to add a dye, a dye, a pigment, or the like as a light-shielding agent to shield visible light, particularly light having a wavelength of 600 nm or less, in order to protect the packaged object.

(Sheet made of thermoplastic norbornene resin)
The method for forming the thermoplastic norbornene-based resin sheet having pockets used in the present invention is not particularly limited. General molding methods for thermoplastic resins, such as injection molding, melt extrusion, hot pressing, solvent casting, and inflation, can be used alone or in combination. For example, after a sheet having no pocket is formed by a method such as solvent casting, melt extrusion, or inflation, the pocket is formed by a vacuum forming method, a pressure forming method, or the like.

The moisture permeability of the sheet without the pocket, when measured in an environment of 40 ° C. and 90 RH%, is converted to a sheet thickness of 300 μm, and is generally 1.0 g / m ² · 24 hours or less for a thermoplastic norbornene resin. The hydrogenated DCP-based ring-opening polymer is 0.6 g / m ² · 24 hours or less, and among the hydrogenated DCP-based ring-opening polymers, among the DCP-based monomer-opened homopolymer hydrogens having no polar group, Additives or DCP monomers having no polar group and norbornene, 1,4: 5,8-dimethano-1,2,3,4,4a, 5,8,8a-octahydronaphthalene or alkyls thereof , Alkylidene and a hydrogenated ring-opened copolymer of an aromatic-substituted derivative can be obtained in an amount of 0.4 g / m ² · 24 hours or less. The hydrogenated DCP-based ring-opening polymer preferably contains at least 50% by weight, more preferably at least 65% by weight, even more preferably at least 80% by weight of a ring-opening repeating structural unit derived from a DCP-based monomer having no polar group. By weight of a ring-opening polymer containing at least 70% by weight, particularly preferably at least 90% by weight, to a hydrogenation rate of at least 70%, preferably at least 90%, more preferably at least 95%, particularly preferably at least 99%. is there. The more the ring-opening repeating structural units derived from the DCP-based monomer are contained, the better the moisture resistance and the lower the moisture permeability.

場合 When forming a pocket by a vacuum forming method after forming a sheet without a pocket, it is preferable to stretch the sheet. As long as the sheets are formed of the same resin and have the same thickness, the stretched sheet has a lower moisture permeability than the unstretched sheet. The stretching is preferably uniaxial stretching. Biaxial stretching complicates the working process, and the reduction in moisture permeability does not differ significantly from a uniaxially stretched sheet. On the other hand, the uniaxial stretching may be a known method.For example, in the case of extrusion molding or inflation molding, it may be performed in a simple process, such as winding while continuously stretching in the extrusion direction with a take-up roll. It is excellent in productivity and has a great effect of improving moisture permeability.

Stretching is performed at Tg to Tg + 100 ° C., preferably Tg + 10 ° C. to Tg + 80 ° C., and the stretching ratio is 110 to 500%, preferably 120 to 400%, more preferably 130 to 250%. If the temperature at the time of stretching is too low, the sheet tends to break during stretching, resulting in poor workability, and when not breaking, the strength of the sheet after stretching may decrease. If the stretching temperature is too high, the workability decreases. If the stretching ratio is too small, the reduction in moisture permeability is small, and if it is too large, the strength of the sheet after stretching is reduced, and pinholes are liable to occur.

For example, a hydrogenated product of a DCP-based ring-opening polymer, particularly a hydrogenated product of a ring-opened homopolymer of a DCP-based monomer having no polar group, or a DCP-based monomer having no polar group and norbornene, 1,4: 5 , 8-Dimethano-1,2,3,4,4a, 5,8,8a-octahydronaphthalene or their hydrogenated ring-opening copolymers of alkyl, alkylidene and aromatic substituted derivatives are 0.25 g / m ^2. 24 hours or less can also be obtained.

The sheet provided with the storage pocket has a thickness of 100 to 500 μm, preferably 150 to 400 μm, more preferably 200 to 350 μm, and the pocket portion has a thickness of 50 to 500 μm, preferably 70 to 350 μm, more preferably 100 to 500 μm except for the pocket portion. The opening and the storage pocket have a shape and a size corresponding to the shape and size of the article to be packaged. If the thickness of the sheet is too large, there is a problem that it is difficult to take out the packaged object because the sheet becomes too strong. If the thickness is too small, there is a problem that the strength is insufficient and the package is easily broken, and the moisture resistance is reduced. This sheet may be further laminated with another resin layer. In addition, this sheet generally has a light transmittance of preferably at least 70%, more preferably at least 80%, particularly preferably at least 90%, so that the packaged object can be easily seen from the pocket portion. .

(Package)
The items to be packaged with the PTP of the present invention are not particularly limited. Representative tablets include pharmaceutical tablets, capsules and the like.

(Pocket closure sheet)
The pocket closing sheet used in the present invention has moisture proof properties and usually has sufficient strength to maintain the packaging. When the pocket portion is pushed, the portion that closed the pocket is easily torn and covered. There is no particular limitation as long as the package can be taken out, but in general, a sheet in which resin layers are laminated on both surfaces of a metal foil is used.

(4) The metal foil has a thickness of preferably 10 to 60 μm, more preferably 15 to 50 μm, and particularly preferably 20 to 40 μm, and an aluminum foil is preferable from the viewpoints of moisture resistance and easy removal of the packaged object. If the thickness of the metal foil is too large, it is difficult to remove the metal foil.

樹脂 The resin to be laminated on both sides of the metal foil is not particularly limited, but when the object to be packaged is a food or a pharmaceutical, the resin should be such that harmful substances do not elute beyond an allowable limit. When the strength of the metal foil is insufficient, a resin that can be reinforced is preferable, and when the moisture resistance of the metal foil is insufficient, a resin having high moisture resistance is preferable.

(Adhesion method)
The method of bonding the sheet having the pocket and the sheet for closing when the object is packaged by closing the pocket opening with the metal foil is not particularly limited. There are a method of performing heat sealing, ultrasonic sealing, dry lamination, wet lamination, etc., and a method of thermocompression bonding using an adhesive. A general method is to form an adhesive layer on a sheet having a pocket or a sheet for closing, and to heat-seal after storing an article to be packaged in a pocket. Further, a pretreatment such as a corona discharge treatment or a plasma treatment may be performed on the sheet having pockets before bonding.

Adhesives include synthetic rubber-based hot melt adhesives, styrene / ethylene / butylene / styrene / block copolymers, styrene / isoprene / styrene / block copolymers, and hydrogenated styrene / isoprene / styrene / block copolymers Special synthetic rubber-based hot melt adhesives, polypropylene-based maleic anhydride graft resin, polyethylene-based maleic anhydride graft resin, modified olefins such as chlorinated polyolefin, ethylene / acrylic acid copolymer, ethylene / methacrylic acid Adhesive resins such as polymers, olefin copolymers such as ethylene / methyl acrylate / maleic anhydride copolymers; Solution-based adhesives such as acrylic, synthetic rubber, and urethane; acrylic, synthetic rubber, and urethane Emulsion type adhesive such as a system;

When used in an environment having a large range of temperature change, a flexible adhesive is used so that the PTP does not curl due to the difference in expansion and contraction between the resin and the metal foil. As described in the publication, a method of bonding only the periphery of the pocket opening is preferable.

Hereinafter, the present invention will be specifically described with reference to Reference Examples, Examples, and Comparative Examples.
Reference Example 1
A DCP ring-opening polymer hydrogenated product (number average molecular weight 26,000, glass transition temperature 93 ° C., hydrogenation rate 99.7% or more, no transition metal was detected) was extruded with a resin extruder having a screw diameter of 65 mm. The sheet was extruded at a temperature of 200 ° C. from a T-die having a width of 400 mm and taken up by a roll at 85 ° C. to produce a sheet having a thickness of 300 μm.
The obtained sheet was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The moisture permeability of this sheet was measured by the method under condition B of JIS Z 0208, and as a result, it was 0.26 g / m ² · 24 hours under the environment of a temperature of 40 ° C. and a relative humidity of 90% RH.

Reference Example 2
70% by weight of DCP-derived ring-opening repeating structural unit and 6-methyl-1,4: 5,8-dimethano-1,4,4a, 5,6,7,8,8a-octahydronaphthalene-derived ring-opening repeating unit The screw diameter of the hydrogenated product of the ring-opening copolymer composed of 30% by weight of the structural unit (number average molecular weight: 28,000, glass transition temperature: 109 ° C., hydrogenation rate: 99.7% or more, and no transition metal was detected) Using a 65 mm extruder, the resin was extruded from a T-die having a width of 400 mm at a resin temperature of 215 ° C. and taken up by a roll at 95 ° C. to produce a sheet having a thickness of 300 μm.
The obtained sheet was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The moisture permeability measured in the same manner as in Reference Example 1 was 0.32 g / m ² · 24 hours.

Reference Example 3
6-methyl-1,4: 5,8-dimethano-1,4,4a, 5,6,7,8,8a-octahydronaphthalene ring-opening copolymer hydrogenated product (number average molecular weight 34,000, A glass transition temperature of 160 ° C., a hydrogenation rate of 99.7% or more, and no transition metal was detected) was extruded from a 400 mm wide T-die at a resin temperature of 260 ° C. using an extruder having a screw diameter of 65 mm. A sheet having a thickness of 300 μm was prepared with a roll.
The obtained sheet was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The moisture permeability measured in the same manner as in Reference Example 1 was 0.76 g / m ² · 24 hours.

Reference example 4
90% by weight of DCP-derived ring-opening repeating structural unit and 6-methyl-1,4,5,8-dimethano-1,4,4a, 5,6,7,8,8a-octahydroxynaphthalene-derived ring-opening repeating unit A hydrogenated product of a ring-opening polymer composed of 10% by weight of structural units (number-average molecular weight: about 35,000, glass transition temperature: 105 ° C, hydrogenation rate: 99.7% or more, and no transition metal was detected) Using a 65 mm extruder, the sheet was extruded from a T-die having a width of 400 mm at a resin temperature of 200 ° C. and rolled at 90 ° C. to produce a sheet having a thickness of 300 μm.
The obtained sheet was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The moisture permeability measured in the same manner as in Reference Example 1 was 0.32 g / m ² · 24 hours.

Reference example 5
A sheet was obtained in the same manner as in Reference Example 1 except that the thickness was changed to 450 μm. The sheet was colorless and transparent, had no defects such as voids and fish eyes, and no external defects such as curl, twist, and wavy. This sheet was uniaxially stretched 1.5 times in an environment of 130 ° C. using a crepe tenter to obtain a sheet having a thickness of 300 μm.
The obtained sheet was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The moisture permeability measured in the same manner as in Reference Example 1 was 0.19 g / m ² · 24 hours.

Reference Example 6
A sheet was obtained in the same manner as in Reference Example 2, except that the thickness was changed to 450 μm, and was colorless and transparent, free from defects such as voids and fish eyes, and from external defects such as curl, twist, and wavy, and having a good appearance. This sheet was uniaxially stretched 1.5 times in an environment of 140 ° C. using a crepe tenter to obtain a sheet having a thickness of 300 μm.
The obtained sheet was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The moisture permeability measured in the same manner as in Reference Example 1 was 0.23 g / m ² · 24 hours.

Reference Example 7
A sheet having good appearance was obtained in the same manner as in Reference Example 3 except that the thickness was changed to 430 μm, and was colorless and transparent, free of defects such as voids and fish eyes, and without external defects such as curl, twist, and wavy. This sheet was uniaxially stretched 1.5 times in an environment of 220 ° C. using a crepe tenter to obtain a sheet having a thickness of 300 μm.
The obtained sheet was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The moisture permeability measured in the same manner as in Reference Example 1 was 0.60 g / m ² · 24 hours.

Reference Example 8
A sheet was obtained in the same manner as in Reference Example 4, except that the thickness was changed to 445 μm, and was colorless and transparent, free from defects such as voids and fish eyes, and from external defects such as curl, twist, and wavy, and having a good appearance. This sheet was uniaxially stretched 1.5 times in an environment of 130 ° C. using a crepe tenter to obtain a sheet having a thickness of 300 μm.
The obtained sheet was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The moisture permeability measured in the same manner as in Reference Example 1 was 0.22 g / m ² · 24 hours.

Example 1
A convex part with a bottom diameter of 12 mm, a top diameter of 10 mm, and a height of 4 mm that engages with a lower mold and a lower mold pocket in which 6 pockets each having a mouth diameter of 14 mm, a bottom diameter of 12 mm, and a depth of 5 mm are arranged at intervals of 3 mm in a length of 6 rows and 2 rows. The sheet obtained in Reference Example 1 was fixed with the lower mold and the upper mold open in a vacuum mold consisting of an upper mold having 6 pieces arranged vertically and 2 pieces arranged horizontally at an interval of 5 mm, and preheated at 140 ° C. for 1 minute. Then, the lower mold and the upper mold were closed, and at the same time, the pressure of the pocket portion was reduced to produce a sheet having pockets.
This sheet transferred the shape of the mold well, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, wavy, and uneven thickness, and had a good appearance. The thickness of the pocket bottom was 190 μm, and the thickness of the pocket side was 120 μm.

A polypropylene-based maleic anhydride graft resin adhesive (Modick M410F, manufactured by Mitsubishi Yuka Co., Ltd.) was applied to the adhesive surface of the sheet with the closing sheet, and dried to form an adhesive layer having a thickness of about 10 μm. After filling each pocket with 0.25 g of silica gel, a 22 μm-thick aluminum foil closing sheet was joined, and the adhesive surface was heated to 100 ° C. and pressed to produce PTP. The adhesion between the sheet having pockets and the sheet for closing was good.
After maintaining this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 10.4 mg.

Example 2
A sheet having pockets was prepared in the same manner as in Example 1 except that the sheet obtained in Reference Example 2 was used instead of the sheet obtained in Reference Example 1, and the residual heat temperature of the mold was set to 150 ° C. This sheet transferred the shape of the mold well, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, wavy, and uneven thickness, and had a good appearance. The thickness of the pocket bottom was 110 μm, and the thickness of the pocket side was 165 μm.
Using this sheet, a PTP was produced in the same manner as in Example 1, but the adhesion between the sheet having pockets and the closing sheet was good. After keeping this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 14.3 mg.

Example 3
A sheet having pockets was prepared in the same manner as in Example 1 except that the sheet obtained in Reference Example 3 was used instead of the sheet obtained in Reference Example 1, and the preheating temperature of the mold was set to 200 ° C. This sheet transferred the shape of the mold well, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, wavy, and uneven thickness, and had a good appearance. The thickness of the pocket bottom was 180 μm, and the thickness of the pocket side was 125 μm.
Using this sheet, a PTP was produced in the same manner as in Example 1, but the adhesion between the sheet having pockets and the closing sheet was good. After maintaining this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 29.8 mg.

Example 4
A sheet having pockets was produced in the same manner as in Example 1 except that the sheet obtained in Reference Example 4 was used instead of the sheet obtained in Reference Example 1. This sheet transferred the shape of the mold well, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, wavy, and uneven thickness, and had a good appearance. The thickness of the pocket bottom was 170 μm, and the thickness of the pocket side was 120 μm.
Using this sheet, a PTP was produced in the same manner as in Example 1, but the adhesion between the sheet having pockets and the closing sheet was good. After maintaining this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 12.7 mg.

Example 5
A sheet having pockets was produced in the same manner as in Example 1 except that the sheet obtained in Reference Example 5 was used instead of the sheet obtained in Reference Example 1. This sheet transferred the shape of the mold well, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, wavy, and uneven thickness, and had a good appearance. The thickness of the bottom of the pocket was 180 μm, and the thickness of the side of the pocket was 130 μm.
Using this sheet, a PTP was produced in the same manner as in Example 1, but the adhesion between the sheet having pockets and the closing sheet was good. After maintaining this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 7.9 mg.

Example 6
A sheet having pockets was produced in the same manner as in Example 1 except that the sheet obtained in Reference Example 6 was used instead of the sheet obtained in Reference Example 1. This sheet transferred the shape of the mold well, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, wavy, and uneven thickness, and had a good appearance. The thickness of the pocket bottom was 160 μm, and the thickness of the pocket side was 120 μm.
Using this sheet, a PTP was produced in the same manner as in Example 1, but the adhesion between the sheet having pockets and the closing sheet was good. After maintaining this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 10.6 mg.

Example 7
A sheet having pockets was produced in the same manner as in Example 1 except that the sheet obtained in Reference Example 7 was used instead of the sheet obtained in Reference Example 1. This sheet transferred the shape of the mold well, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, wavy, and uneven thickness, and had a good appearance. The thickness of the pocket bottom was 170 μm, and the thickness of the pocket side was 125 μm.
Using this sheet, a PTP was produced in the same manner as in Example 1, but the adhesion between the sheet having pockets and the closing sheet was good. After maintaining this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 23.7 mg.

Example 8
A sheet having pockets was produced in the same manner as in Example 1 except that the sheet obtained in Reference Example 8 was used instead of the sheet obtained in Reference Example 1. This sheet transferred the shape of the mold well, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, wavy, and uneven thickness, and had a good appearance. The thickness of the pocket bottom was 170 μm, and the thickness of the pocket side was 120 μm.
Using this sheet, a PTP was produced in the same manner as in Example 1, but the adhesion between the sheet having pockets and the closing sheet was good. After maintaining this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 9.3 mg.

Comparative Example 1
A sheet having pockets was produced in the same manner as in Example 1 except that a polyvinyl chloride sheet having a thickness of 300 μm was used instead of the sheet obtained in Reference Example 1, and the residual heat temperature of the mold was set to 125 ° C. This sheet had a good transfer of the mold shape, was colorless and transparent, had no defects such as voids and fish eyes, no external defects such as curl, twist, and wavy, and had a good appearance. The thickness of the bottom of the pocket was 160 μm, and the thickness of the side of the pocket was 135 μm.
Using this sheet, a PTP was produced in the same manner as in Example 1, but the adhesion between the sheet having pockets and the closing sheet was good. After maintaining this PTP in an environment of 40 ° C. and 90 RH% for 5 days, the weight increase was measured and found to be 137.2 mg.

Claims (5)

After storing an article to be packaged in a storage pocket provided in a sheet made of a thermoplastic norbornene-based resin and having the following thickness, the pocket opening of the sheet is closed with a metal foil having a thickness of 10 to 60 μm, and the article to be packaged is closed. Press-through package.
The thickness of the storage pocket portion is 50 to 500 μm, and the thickness other than the storage pocket portion is 100 to 500 μm. The thermoplastic norbornene-based resin, sheet thickness 300 [mu] m, 40 ° C., a press-through according to claim 1, wherein those having a moisture permeability of less 1.0 g ^{/ m} 2 · 24 hours when measured under the conditions of 90 RH% ·package. The press-through package according to claim 1, wherein the metal foil is an aluminum foil. 2. The press-through package according to claim 1, wherein the metal foil has a resin layer laminated on both surfaces thereof. 5. The press-through package according to claim 1, wherein the sheet made of a thermoplastic norbornene resin is provided with a storage pocket in a uniaxially stretched sheet.