JP2003334504A - Allergen removing agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an allergen removing agent capable of efficiently removing an allergen substance in an organism such as a mite, or the like, or remains or excrement thereof by simple cleaning operation without changing the touch of an object, and an allergen removing method. <P>SOLUTION: The allergen removing agent contains (a) an organic compound forming an azeotropic mixture along with water and becoming <100°C in the azeotropic temperature with water under 1013.25 hPa, (b) an organic compound with a melting point of 25°C or higher (excepting a surfactant and an organic acid), (c) an organic compound other than the organic compounds (a) and (b), and (c) water in a specific ratio. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an agent and method for effectively removing allergens that are difficult to remove by ordinary cleaning, and more particularly to carcasses and feces of mite, mold spores, TECHNICAL FIELD The present invention relates to an agent and a method for efficiently removing allergen, which is a substance that becomes an allergic antigen such as pollen.

[0002]

2. Description of the Related Art In recent years,
As the living environment changes, the breeding of house mites is promoted, and the presence of causative agents of allergic diseases such as asthma, atopic dermatitis or allergic rhinitis is becoming apparent. In particular, mite species such as mosquito leopard mite, Dermatophagoides farinae or Dermatophagoides farinae inhabit rugs such as tatami mats and carpets, blankets, beddings such as duvets, and multiply.
Such control of mites is of great interest not only to people with allergic diseases but also to ordinary households. Many techniques have been proposed for anti-mitic agents and acaricides. For example, in JP-A-9-157116, phenylisothiocyanate is contained as an anti-mite component, and a fragrance selected from a sesquiterpene compound, an alicyclic compound or an aromatic compound is contained as a pungent odor reducing component of phenylisothiocyanate. Anti-mitic agents are described. However, carcasses and feces are also known to be allergens, and detoxification of these allergens is being studied.

Japanese Unexamined Patent Publication (Kokai) No. 6-279273 discloses a method for removing allergens using a specific compound such as gallic acid or its lower alcohol ester. JP-A-6
Japanese Unexamined Patent Publication No. 1-48421 discloses an allergen remover containing tannic acid and a specific solvent. Further, JP-A-2000-63207 discloses that a specific solvent is effective for detoxifying allergen. However, in these techniques, Ig which causes the allergen to develop by denaturing allergen protein.
The purpose is to reduce the binding ability with the E antibody. However, the allergen or its precursor still remains and does not have a satisfactory allergen removal effect. When repeatedly exposed to allergens modified by these techniques, the modified allergen itself becomes a new allergen substance, which may be a factor of allergic onset. Further, when such a composition is repeatedly used by spraying a target object such as a carpet or tatami mat, the target object causes a change such as sticky feeling, and this improvement is required.

On the other hand, it is known that it is effective to carefully clean mites and allergens derived from organisms such as mite feces, pollen and mold spores by using a cleaning tool such as a vacuum cleaner. However, rugs such as tatami mats and carpets, and bedding such as blankets and duvets cannot be easily removed because the allergen substances are present deep inside them. For example, cleaning the floor with a vacuum cleaner for more than 20 seconds per 1 m ² and with bedclothes carefully once a week are effective methods to effectively remove mite allergen from the indoor environment. However, it is very difficult to carry out on a daily basis. Therefore, a method for efficiently removing the allergen with a simple cleaning operation is required.

By the way, as a cleaning agent for carpets in which mites live, after spraying a powder impregnated with a cleaning liquid on the carpet, rubbing the powder with the carpet using a brush, and then sucking the powder with a vacuum cleaner. Methods of cleaning carpets are known. As another carpet cleaning agent, JP-A-53-130704 discloses a lithium salt of a sulfuric acid ester of a mixed alcohol obtained by blending 80 to 95 parts of lauryl alcohol and 5 to 20 parts of decyl alcohol. 70 to the P ₂ O ₅ as a builder
A liquid carpet shampoo composition containing water such that the total solid content of the composition comprising lithium salt of polyphosphoric acid of 85% is 10 to 40% is described, and further, the carpet shampoo is treated with water. It is described that the diluted product is sprayed onto a carpet, spread on the carpet surface, rubbed by brushing, and vacuumed to remove powdered washing liquid residue after drying. In addition, JP-A-46-
Japanese Patent No. 2934 describes a cleaning composition used for a carpet or the like made of a water-soluble organic surfactant, a higher swelling fatty alcohol and a water-insoluble silicic acid compound, and foams made of the composition on the carpet. It is described that it is allowed to form, the bubbles disappear and it is dried before being treated with a vacuum cleaner. Also,
As a commercial carpet cleaner, a product is commercially available that is cleaned by spraying a liquid detergent, polishing with a polisher, and then sucking powder after drying. As described above, a method of applying a powder or liquid for cleaning a carpet and sucking the dried powder with a vacuum cleaner or the like is already known. However, these carpet washings are not intended to remove allergens, but are detergents intended to remove carpet stains, and therefore use a surfactant or a powdery adsorbent as a main base material. . However, for the purpose of removing allergens, it is desirable that the concentration of such a solid source be small and a sufficient effect can be obtained. Carbon number 1
A surfactant of 2 or less has a problem that it tends to remain on the treated surface.

Therefore, an object of the present invention is to provide an allergen removing agent and an allergen removing method which can efficiently remove allergen substances such as organisms such as mites and their carcasses or feces by a simple cleaning operation, and do not change the feel of the object. To provide.

[0007]

The present invention relates to (a) an organic compound which forms an azeotropic mixture with water and has an azeotropic temperature with water at 1013.25 hPa of less than 100 ° C. [hereinafter,
1 to 70% by mass, (b) melting point is 2)
Organic compounds at 5 ° C. or higher (excluding surfactants and organic acids) [hereinafter referred to as component (b)] 0.001 to 5% by mass, organic compounds other than (c), (a) and (b) [below ,
0 to 5 mass% of component (c)], and (d) water [hereinafter referred to as component (d)], and (b) / [(b) +
(C)] relates to an allergen remover having a mass ratio of 0.15 or more.

Further, the present invention is an allergen-removing method for removing an organic compound containing an allergen deposited by applying or spraying an aqueous solution containing an organic compound having a melting point of 25 ° C. or higher onto a target surface on which the allergen is present. Regarding the method.

According to the present invention, the above-mentioned component (a), (b)
Component, component (c) and component (d), and (b) /
[(B) + (c)] is an allergen remover having a mass ratio of 0.15 or more, and includes the allergen deposited after being applied to a target surface on which the allergen is present by application, spraying, or the like. ) An allergen removing agent for use in an allergen removing method for removing a component is provided.

Further, according to the present invention, the above-mentioned component (a) 1
~ 70 mass%, 0.001 to 5 mass% of the component (b),
(C) component 0 to 5 mass% and (d) water are contained,
An aqueous solution in which (b) / [(b) + (c)] is 0.15 or more in a mass ratio is applied to the target surface on which the allergen is present, and the allergen is deposited together with the solid deposited by drying on the target surface. There is provided a method for removing an allergen to be removed from a.

In the present invention, the allergen is usually
Broadly refers to the causative agent of allergies, in the present invention, especially mite, chironomid, cockroaches and those carcasses or those feces dusted, broken pet hair, dried products of proteins in saliva of pets, Refers to pollen and mold spores. The allergen remover of the present invention is difficult to clean and remove among these allergens.
It is effective for removing those having a thickness of μm or less.

In the present invention, the allergen remover is
Treatment with the agent facilitates removal of the allergen from the target surface.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION <Component (a)> The component (a) of the present invention forms an azeotrope with water to form 1013.25 hPa.
Azeotropic temperature with water at (760mmHg) is 100 ℃
It is an organic compound that is less than less than 4
Edition The Chemical Society of Japan Maruzen Co., Ltd. II-147 Table 8
From the compounds described in 43, which form an azeotropic mixture with water, compounds having an azeotropic temperature of less than 100 ° C, preferably 60 to 90 ° C can be used. Preferred specific examples are ethanol, cyclohexane, 2-butanol, cyclohexanol, cyclohexanone, cyclohexane, toluene, 1-butanol, 2-butanol, 1-propanol, 2-propanol, 1-hexanol, hexane,
1-heptanol, 1-pentanol, and 2-pentanol can be mentioned, and an alcohol compound having 2 to 7 carbon atoms is preferable. Especially ethanol, 1-propanol,
2-Propanol is most preferable from the viewpoint of the allergen removing effect.

<Component (b)> The melting point of component (b) is an important factor in the method of removing allergen. From the nature of the present invention, the melting point of the component (b) may be higher than the temperature of the surface from which the allergen is desired to be removed.
The melting point of the component (b) is specified as 25 ° C or higher. However, in consideration of hot seasons such as summer, those having a melting point of 35 ° C. or higher are preferable.

The component (b) is the most important component in the present invention. The component (b) has the property of being dissolved in the component (a) and / or the component (d) and forming a solid resulting from the component (b) itself or the component (b) after drying the solution.
The component (b) is at least (a) in the allergen remover.
It is a solid source substance which is present in a dissolved state in the component and / or the component (d), and produces a solid by evaporation of the liquid component in the removing agent. Here, the evaporation of the liquid component does not mean that all of the liquid component evaporates, but means the amount of evaporation of the liquid component sufficient for producing a solid. That is, the liquid components in the allergen remover of the present invention are mainly the components (a) and (d), but when a small amount of liquid components having low volatility such as a fragrance described later are included, they do not necessarily have to be evaporated. There is no. By containing the component (b) exhibiting such properties, the allergen remover of the present invention is sprayed or applied onto the target surface (object to be treated) where the allergen is present, and then the treated portion is dried. This produces a solid. At that time, the solid is considered to improve the allergen removal efficiency by cleaning, for the reason that the solid is generated by supporting the allergen, or the allergen is easily separated from the surface of the target surface.

Since the allergen remover of the present invention applied by spraying or the like has a high drying rate due to the component (a),
The organic compound as the component (b) is solidified on the surface to be an allergen removal target and captures the allergen, so that the removal by cleaning is facilitated.

The component (b) preferably has low hygroscopicity so that the treated allergen can be easily removed from the target surface. Regarding the hygroscopicity, the hygroscopicity measured by the following hygroscopicity test is 0 to 2, preferably 0 to 1, and particularly 0 to
A compound of 0.5 is preferred.

(Hygroscopicity test) The component (b) is pulverized and classified to 500 to 1000 μm by a sieve. 1 g (Wa) of this classified material is put into a cylindrical glass dish having a diameter of 7 cm and a depth of 1.5 cm, and the total mass is measured (W
b). Next, after leaving it in a thermostatic chamber at a humidity of 80% and a temperature of 20 ° C. for 24 hours, the total mass is measured (Wc), and the moisture absorption is calculated by the following formula. Moisture absorption = (Wc-Wb) / Wa

Further, it is preferable that the component (b) has poor solubility in water. Specifically, the solubility in water at 20 ° C. is preferably 0.02 g / 100 g or less, more preferably 0.01 g / 100 g or less, but (b)
The component is preferably in a dissolved state in the allergen remover, and therefore the solubility in the component (a) is preferably 0.05 g / 100 g or more, more preferably 0.1 g /
It is 100 g or more. Here, the solubility can be determined by the method described in Chemistry Dictionary 9 (Kyoritsu Publishing Co.), page 399, solubility test.

As the specifically preferred compound of the component (b), compounds selected from the following (1) to (3) are suitable. (1) Melting point is 40 to 250 ° C., preferably 60 to 210
C, 10 to 25 carbon atoms, preferably 10 to 20 alicyclic compound (2) melting point is 35 ℃ or more, preferably 35 to 200 ℃,
Specific examples of aromatic compounds (1) having 8 to 36 carbon atoms, preferably 12 to 20 aliphatic compounds (3) having a melting point of 40 to 200 ° C. and 7 to 24 carbon atoms, and preferably 7 to 20 Is camphene,
1-menthol, borneol, cedrol, t-butylcyclohexanol, camphor, p-t-butylcyclohexanone, maltol, cyclopentadecanone,
Examples thereof include hinokitiol, caryophyllene oxide, and buccoxime (manufactured by Dragoca).
Specific preferred compounds of (2) include myristyl alcohol, palmityl alcohol, stearyl alcohol, and n-tetradecyl aldehyde. Specific preferred compounds of (3) include dimethylphenylcarbinol, phenylglycol, vanillin, ethylvanillin, benzophenone, methylnaphthylketone, coumarin, musk xylene, musk ketone, musk ambrette, musk tibetan, musk moskene (manufactured by Givaudan), Celestolide (manufactured by IFF), Versalide (manufactured by Givaudan), Tonalide (manufactured by PFW Aroma Chemical), dimethylhydroquinone, thymol, trans-benzylisoeugenol, β-naphthol methyl ether, benzoic acid, cinnamic acid, phenylacetic acid, hydro. Cinnamic acid, isoeugenol acetate, cinnamyl cinnamate, phenylethyl salicylate, methyl anisate, indole, skatole, rosephenone, methyl atralate, raspberry ketone, helio. Ropiruaseton, 3-
Methyl-4-isopropylphenol, p-chloro-m
Mention may be made of xylenol. These compounds (3) have a solubility in water at 20 ° C. of 0.02 g / 1.
The solubility in component (a) at 20 ° C. is 0.05 g / 100 g or more.

In the present invention, it is particularly preferable to use one or more compounds selected from (1) and (2) from the viewpoint of the effect of removing allergen, and especially cedrol, 1-menthol, myristyl alcohol, palmityl alcohol, stearyl alcohol. , Camphene and thymol are preferred.

Although the surfactant is excluded from the component (b) of the present invention, the surfactant of the present application is c. m. A compound having c (critical micelle concentration), or having an HLB of 6 or more as determined by the method described in Surfactant Handbook (Sangyo Tosho Co., Ltd., published in 1960), page 319, or both. Therefore, a compound that does not have these properties and has a melting point of 25 ° C. or higher is treated as the component (b). Further, in the present invention, the organic acid is not included in the component (b).

<Component (c)> The component (c) of the present invention is
It is an organic compound other than the components (a) and (b) and is an optional component in the present invention. Specific examples include fragrance components other than the components (a) and (b), surfactants, organic acids, and other organic solvents.

As the fragrance component (hereinafter referred to as the component (c-1)), "chemistry of fragrance" (edited by Ryoichi Akahoshi, edited by The Chemical Society of Japan)
Industrial chemistry series, published on September 16, 1983), "Synthetic fragrance chemistry and product knowledge" (Genichi Indo, Kagaku Kogyo Nipposha, published March 6, 1996) and "Actual knowledge of fragrances and perfumes" The materials described in Motoki Nakajima, Sangyo Tosho Co., Ltd., published June 21, 1995 can be used. Further, in the present invention, for the purpose of improving the allergen reducing effect, "well-known / common technique collection (fragrance) Part 1 general fragrance" 2.
`` Attractants, repellents, pheromones '' described in section 6.4 and 2.
"Insecticide" described in Section 6.5 and Japanese Patent Application No. 2001-94696
It is preferable to use at least one selected from those described in the publication.

Specifically, α-pinene, β-pinene, cis-3-hexenyl benzoate, hexyl benzoate, benzyl benzoate, eugenol, caryophyllene, carvone, geraniol, cis-3-hexenyl salicylate,
Hexyl salicylate, Santalol, citral, citronellal, citronellol, phenylethyl alcohol, hexylcinnamic aldehyde, benzyl alcohol, menthone, linalool, jasmon, dihydrojasmon, methyl jasmonate, dihydrojasmonate methyl, farnesol, nerolidol, phenoxyethanol, cineol. , Linalyl formate, cinnamic aldecht, isophytol, phytol, cedolyl methyl ether, β-damascon, α-damascon, β-ionone, α-ionone, tetrahydrolinalool, linal (manufactured by IFF), benzaldecht, benzoic acid n -Amyl, isoamyl benzoate, heptyl benzoate, phenylethyl benzoate, n-butyl salicylate, isobutyl salicylate, salicyl Selected from n-amyl, isoamyl salicylate, methyl salicylate, benzyl salicylate, n-benzyl butyrate, benzyl isobutyrate, benzyl n-valerate, benzyl isovalerate, benzyl propionate, benzyl hexanoate, benzyl octanoate, phenylpropyl alcohol. Particularly preferred is one or more selected from jasmon, dihydrojasmon, methyl jasmonate, methyl dihydrojasmonate, farnesol and nerolidol. Further, in the present invention, such a fragrance component can be used alone, but can also be used as two or more kinds of fragrance compositions.

In the present invention, it is also preferable to use natural essential oil extracted from plants as the component (c-1). As the natural essential oil, peppermint oil, almond oil, columbus oil, peppermint oil, spearmint oil, cinnamon oil, allspice oil, clove oil, thyme oil, rosemary oil, lemongrass oil, lemon oil, yuzu oil, lime oil, Grapefruit oil, Mandarin oil, Ajowan oil, Bergamot oil, Laurel oil, Star anise oil, Marjoram oil, Mace oil, Boad rose oil, Palmarosa oil, Lemon verbena oil, Lemon balm oil, Lavender oil, Rose oil, Orange oil, Cassia oil, Cassie Oil, garlic oil, kayak oil, perilla oil, cinnamon oil, camphor oil, cedar wood oil, baturi oil, cypress oil, hiba oil, rice oil, beny royal oil, lycea cubeba oil, eucalyptus oil, tea tree oil, ylang ylang oil, Vetiver oil, cananga oil, citronella oil, na Meg oil, pepper oil, sandalwood oil,
Examples thereof include ginger oil, anise oil, mace oil, fennel oil and the like.

Among them, ylang-ylang oil, orange oil, clove oil, sandalwood oil, spearmint oil, cedarwood oil, thyme oil, tea tree oil, peppermint oil, palmarosa oil, cypress oil, hiba oil, peppermint oil, penny Royal oil, eucalyptus oil, lavender oil,
Lemongrass oil, lemon oil, rosemary oil, camphor oil,
One or more selected from Ajowan oil is preferable.

Although these essential oils include compounds having a melting point of 25 ° C. or higher, in the present invention, compounds having a melting point of 25 ° C. or higher in natural essential oil are treated as the component (b).

In the present invention, a surfactant can be used as the component (c-2), and particularly from the viewpoint of imparting a transparent appearance to the composition and / or from the viewpoint of storage stability, a nonionic surfactant or anionic surfactant is used. Formulation of ionic and cationic surfactants can be considered.

Examples of the nonionic surfactant include compounds represented by the following general formula (1) and / or general formula (2).

R ¹ —O— (R ² O) _a —H (1) [wherein R ¹ has 8 to 18 carbon atoms, preferably 10 to ¹ carbon atoms]
6 is an alkyl group or an alkenyl group, R ² is an alkylene group having 2 or 3 carbon atoms, and is preferably an ethylene group. a represents an average number of added moles of 3 to 20, preferably 4 to 15, and particularly preferably 5 to 10. ] _{^{R 3 - (OR 4) b}} G c (2) wherein, R ³ is 8 to 16 carbon atoms linear, preferably 10
To 16 and particularly preferably 10 to 14 alkyl groups, R ⁴
Is an alkylene group having 2 to 4 carbon atoms, preferably an ethylene group or a propylene group, especially an ethylene group, G is a residue derived from a reducing sugar, b is a number having an average value of 0 to 6, and c is an average value of 1.
-10, preferably 1-5, particularly preferably 1-2. ].

Among the compounds of the general formula (1), particularly preferred compounds include the compounds of the following general formula (1-1) or the compounds of the general formula (1-2).

R ⁵ —O (EO) _d —H (1-1) [wherein, R ⁵ has 10 to 18 carbon atoms, preferably 10 to 1 carbon atoms]
6 is a primary linear alkyl group, a branched alkyl group or a secondary alkyl group. EO is ethylene oxide, and d is 3 to 20 as the average number of added moles. ] R < ⁶ > -O [(EO) _e / (PO) _f ] -H (1-2) [In formula, R < ⁶ > has a carbon number of 10-18, Preferably it is 10-1.
6 primary alkyl group. EO is ethylene oxide and PO is propylene oxide. e is an average added mole number of 3 to 15, and f is an average added mole number of 1 to 5. E
Regarding O and PO, PO may be added after random addition or EO is added, and vice versa. ].

In the compound of the general formula (2), G is a residue derived from a reducing sugar, and the reducing sugar as a raw material may be either aldose or ketose and has 3 to 6 carbon atoms. Mention may be made of triose, tetrose, pentose, hexose. Specific examples of aldoses include apiose, arabinose, galactose, glucose, lyxose, mannose, galose, aldose, idose, talose and xylose, and examples of ketose include fructose. In the present invention, of these, aldopentose or aldohexose having 5 or 6 carbon atoms is particularly preferable, and glucose is most preferable.

The anionic surfactant has 10 to 10 carbon atoms.
Alkyl or alkenyl benzene sulfonate, alkyl or alkenyl sulphate ester salt, α-olefin sulfonate, α-sulfo fatty acid salt, α-sulfo fatty acid lower alkyl having 24, especially 10 to 18 alkyl or alkenyl groups A surfactant selected from ester salts or fatty acid salts, alkenylsuccinic acid or salts thereof is suitable.

As the salt, sodium salt, potassium salt, magnesium salt, calcium salt, alkanolamine salt,
Ammonium salts are preferable, and sodium salts, potassium salts, and magnesium salts are preferable from the viewpoint of cleaning effect.

Examples of the cationic surfactant include compounds represented by the following general formulas (3) to (5).

[0038]

[Chemical 1]

[Wherein, R ⁷ and R ¹² are each an alkyl group or an alkenyl group having 5 to 16 carbon atoms, preferably 6 to 14 carbon atoms, preferably an alkyl group, and R ⁹ and R 12
Each of ¹⁰ is an alkyl group having 1 to 3 carbon atoms or a hydroxyalkyl group. T is -COO-, OCO-, -C
ONH-, -NHCO-,

[0040]

[Chemical 2]

It is g is a number of 0 or 1. R
⁸ is an alkylene group having 1 to 6 carbon atoms, or-(OR ¹⁷ ) _n
− Here, R ¹⁷ is an ethylene group or a propylene group, preferably an ethylene group, and n is a number having an average value of 1 to 10, preferably 1 to 5. R ¹¹ is an alkylene group having 1 to 5 carbon atoms, preferably 2 or 3. Two or more (preferably two) of R ¹³ , R ¹⁴ , R ¹⁵ , and R ¹⁶ are alkyl groups having 8 to 12 carbon atoms, and the rest are alkyl groups having 1 to 3 carbon atoms or hydroxy. It is an alkyl group. Z ⁻ is an anion group, preferably a halogen ion, or an alkylsulfate ion having 1 to 3 carbon atoms. The following are examples of the most preferable cationic surfactant of the present invention.

[0042]

[Chemical 3]

In the present invention, the component (b), the component (c-1) and the like are solubilized in the composition to enhance storage stability.
The component (c-2) surfactant, especially a nonionic surfactant, can be added. However, the surfactant is
It is considered that the precipitation of a solid containing the component (a) is hindered,
The blending amount is limited.

In the present invention, an organic acid can be used as the component (c-3). Specific examples thereof include organic acids such as citric acid, succinic acid, malic acid, fumaric acid, tartaric acid, malonic acid and maleic acid. These may be blended as a salt.

Further, in the present invention, other organic solvent can be used as the component (c-4). In particular,
Examples thereof include glycol-based compounds such as ethylene glycol and propylene glycol, glycol-based organic solvents such as diethylene glycol monoalkyl ether having an alkyl group having 2 to 4 carbon atoms, and (a) component and (b).
Although lower alcohols other than the components may be mentioned, methanol is not included in the component (c) in the present invention because of its high volatility.

<Allergen Remover> The allergen remover of the present invention is in the form of an aqueous solution in which the component (b) and, if necessary, the component (c) are dissolved in water and solvent which are the components (a) and (d). Is. The component (b) is particularly important in the present invention, and the component (b) has a function of collecting and exfoliating the allergen substance from the surface of the object. Specifically, when the allergen-removing agent of the present invention is sprayed or dipped into an object and dried, the solid of the component (b) is deposited on the surface of the object. At this time, the component (b) is deposited while embracing allergen substances such as organisms such as mites and their carcasses or feces, or the action of the allergen substance itself by some action accompanying the precipitation of the solid of component (b). It is considered to facilitate peeling from the target surface. The allergen can be easily removed by wiping it off with a cloth such as a towel or removing it with a cleaning tool such as a vacuum cleaner. The content of the component (b) is 0.001 to 5% by mass, preferably 0.005 to 5% by mass in the allergen-removing agent in order to suppress stickiness on the target surface and to exert the above-mentioned action.
3% by mass, more preferably 0.005 to 1% by mass, and particularly preferably 0.005 to 0.5% by mass.

The component (a) is used to promote the function of the component (b). That is, the component (a) is for the purpose of uniformly dissolving the component (b), which is insoluble or sparingly soluble in water, in the composition and for promoting the drying after spraying or coating, and to the target surface of the component (b). It is used for the purpose of promoting the precipitation of
In order to obtain such an effect, the content of the component (a) in the present invention is 1 to 70% by mass, preferably 5 to 60% by mass, and particularly preferably 15 to 60% by mass in the allergen removing agent.

Further, the component (c) of the present invention is used for assisting the dissolution of the component (b) in the agent, for imparting anti-mitic / miticidal and bactericidal properties depending on the base material, or for imparting a scent, It is added as an optional component for the antibacterial and antifungal properties of the agent itself and a part of the pH adjustment described later. However, since a large amount of the component (c) may interfere with the action and effect of the component (b) and the allergen, the amount of the component (c) blended should not impair the action of the component (b) of the present invention. Adjusted. Therefore, the content of the component (c) is 0 to 5 in the allergen remover.
%, Preferably 0.001 to 3% by mass, more preferably 0.001 to 1% by mass.

Since some of the components (c) inhibit the precipitation of the components (b), caution should be exercised in their blending. The content of the fragrance component as the component (c-1) is preferably 0.001 to 1% by mass, more preferably 0.001 to 0.5% by mass, and further preferably 0.001 to 0% in the allergen remover. It is 0.3% by mass. Further, the compounding of the surfactant as the component (c-2) may improve the stability of the component (b) or the component (c-1) in the liquid, while affecting solidification and adhesiveness. It is conceivable that it may be difficult to remove solids from the target surface, and since it is likely to remain on the target surface, when used in an allergen removal method in which the treatment of the present invention is routinely performed several times. However, the blending amount is limited. On the other hand, the component (c-2) can be expected to improve the appearance and storage stability of the liquid as described above. From these balances, the component (c-2) in the allergen removing agent is 1% by mass or less, further 0.7% by mass or less,
Particularly preferably, 0.001 to 0.5 mass% may be blended. The component (c-3) can be blended as a pH adjuster, and can be solidified after drying, and some organic acids or salts thereof having no tackiness precipitate solid together with the component (b). Therefore, it can be blended, but some substances are considered to inhibit solid precipitation like a surfactant, and some have adhesiveness, so be careful.
When the component (c-4) is blended, the proportion thereof is 0 to 5% by mass, further 0 to 2% by mass, and especially 0 to 0% by mass in the allergen remover.
1 mass% is preferable.

As described above, the allergen remover of the present invention is composed of components that do not inhibit the action of component (b). Particularly, when a large amount of the component (c) is blended, the same organic compound as that of the component (b) may possibly suppress the precipitation of the component (b) on the target surface. In the allergen remover of the present invention,
The mass ratio of (b) / [(b) + (c)] is 0.15 or more, preferably 0.2 or more, more preferably 0.5 or more, and most preferably 0.5 to 0.98, Especially when the component (c-2) is present, (b) / [(b) + (c-2)]
Is preferably 0.5 or more, more preferably 0.8 or more in terms of mass ratio.

In the present invention, the water as the component (d) is contained in the allergen-removing agent in an amount of 30 to 99% by mass, preferably 30 to 95%.
%, Particularly preferably 40 to 85% by mass, 20
It is suitable to adjust the pH at 3 to 9 and preferably 4 to 8. As the pH adjuster, inorganic acids such as hydrochloric acid and sulfuric acid, acid agents such as the organic acids exemplified as the component (c-3), sodium hydroxide, potassium hydroxide, ammonia and its derivatives, monoethanolamine and diethanolamine, Amine salts such as triethanolamine,
Alkaline agents such as sodium carbonate and potassium carbonate are preferably used alone or in combination, and especially hydrochloric acid,
It is preferable to use an acid selected from sulfuric acid and citric acid and an alkaline agent selected from sodium hydroxide and potassium hydroxide.

The allergen remover of the present invention preferably contains the component (a), the component (b), the component (c) and the component (d) in a total amount of 95 to 100% by mass, more preferably 98 to 10% by mass.
It is 0 mass%.

The allergen remover of the present invention has a viscosity of 20 m at 20 ° C. of the allergen remover for the purpose of facilitating treatment of an object and improving the allergen removing effect.
It is suitable to adjust to Pa · s or less, preferably 1 to 10 mPa · s. By adjusting to such a viscosity, the object can be uniformly treated, and further, the drying and the precipitation of the component (b) can be promoted.

<Method for removing allergen> In the present invention, a completely new method for removing allergen by spraying the above-mentioned allergen-removing agent on a target surface and then removing the allergen substance incorporated in the component (b) with a cleaning tool or the like. Is provided. That is, a method for removing allergen is provided, in which an aqueous solution containing an organic compound having a melting point of 25 ° C. or higher is applied or sprayed on a target surface on which an allergen is present, and the organic compound including the allergen deposited after drying is removed.

A trigger type sprayer or an aerosol type sprayer is preferably used as the sprayer.

When a trigger type sprayer is used, the sprayer has a stroke of 0.1 to 2.0 g, preferably 0.2 to 1.5 g, more preferably 0.3 to 1.0 g.
The thing that gushes out is good. Particularly preferred as the trigger type spray container used in the present invention is a practical spray container 4-
A pressure-accumulation trigger as disclosed in Japanese Patent No. 37554 is particularly good in terms of spray uniformity.

When an aerosol type sprayer is used, it is preferable that the sprayer sprays 0.5 to 5.0 g per second, preferably 1.0 to 3.0 g per second. As the aerosol propellant, liquefied propane gas, dimethyl ether, nitrogen, carbon dioxide, air and the like can be used, but from the viewpoint of injection characteristics, liquefied propane gas is preferable, and from the viewpoint of safety, nitrogen and carbon dioxide. , Air is preferred. Although it is considered that a part of the propellant corresponds to the component (c-4) of the present application, it is 0 ° C., 1013.25 hP.
The organic substance that is a gas in a is not included in the constituent components of the allergen remover of the present invention.

As for the spraying property, the area on which the liquid is applied is 100 to 800 cm ² , preferably 1 when sprayed from a position 15 cm away from an object placed vertically on the ground.
Trigger atomizers of 50 to 600 cm ² are preferred. Further, in the present invention, the component (b) is 1000 cm
^A high allergen-removing effect can be obtained by uniformly spraying the target substance at a dose of 1 to 10 mg, preferably ^{2 to 5} mg per ² and drying.

After spraying, the allergen can be efficiently removed by allowing the cloth to dry naturally and then removing the object with a cloth such as a towel or a cleaning tool such as a vacuum cleaner. The composition suitable for this method is as described above.

[0060]

Example The allergen remover shown in Table 1 was prepared. The allergen-removing effect and the feel when the object prepared by the following method was treated by the following method were measured. The results are shown in Table 1.

(1) Measurement of allergen removal rate 10 cm of a used carpet (Sansetsu Co., Ltd. "Sanseseal CL-1") used at home for 3 years
I cut it in all directions.

0.3 g of the sample was sprayed uniformly on the cut carpet (a smoother trigger container manufactured by Kao Corporation was used. The spray amount of one stroke was 0.3 g, and the spray was applied to a vertically placed target surface. When sprayed from a distance of 15 cm, the area to which the liquid was applied was 420 cm ² , and after drying at room temperature for 30 minutes, it was sucked for 1 second by a vacuum cleaner with a suction power of 250 W equipped with a new paper pack. .

[0063] Then, pH 7.4 ± 0.1 phosphate buffer solution _{(KH 2 PO 4, NaCl,} Na 2 HPO 4 · 7H 2 O , respectively 0.144 g / L,
The allergen collected in the paper pack was extracted with 50 mL of 9.00 g / L, 0.795 g / L dissolved in distilled water (hereinafter referred to as PBS) (this extract was removed to obtain an allergen extract). Call). Further, the allergen remaining on the carpet was extracted using 50 mL of PBS (this extract is referred to as a residual allergen extract).

For each extract, sandwich EL
The concentration of Der f II (allergen contained in the body of Dermatophagoides farinae) was quantified using the ISA method. The sandwich ELISA method was performed as follows. 1. Monoclonal antibody 15E11 (Seikagaku Corporation) was diluted with PBS to a concentration of 2 μg / ml and 50 μ was added to each well of a microplate (Sumitomo Bakelite ELISA PLATE H TYPE).
Dispense each l and let stand at room temperature for 2 hours. 2. Wash plate 3 times with PBS. Dispense 200 μl of PBS containing 1% BSA (Dainippon Pharmaceutical Block Ace) into each well, leave at room temperature for 1 hour, and perform blocking. 4. The plate is washed 3 times with PBS containing 0.05% by mass of Tween 20 (SIGMA) (hereinafter referred to as T-PBS). 5. RDer f II (Seikagaku Corporation) as a standard was diluted from 0.3 μg / ml with 9-tube T-PBS 2 ^n- fold, 50 μl of each was dispensed into each well, and rDer f II was used as a negative control instead of rDer f II. Prepare a well containing 50 μl of T-PBS. The sample to be measured is appropriately diluted with T-PBS, and then 50 μl is dispensed into each well. Let stand for 2 hours at room temperature. 6. The plate is washed 3 times with T-PBS. 7. An optimal concentration of HRP-labeled 13A4 (Seikagaku Corporation) was dispensed into each well in an amount of 50 μl and allowed to stand at room temperature for 2 hours. 8. The plate is washed 3 times with T-PBS. 9. Color is developed using a peroxidase coloring kit T (Sumitomo Bakelite). First, add 10 mL of substrate solution to 10 mL of color former.
Add 1 mL and mix to obtain a color-developing solution. 100 μl of this color-developing solution is dispensed into each well, and color is developed at room temperature. Then, 100 μl of the stop solution is dispensed into each well to stop the reaction, and the absorbance at 450 nm is measured with a plate reader. 10. The Der fII concentration of the sample to be measured is calculated using the calibration curve obtained from the absorbance of the standard.

With respect to the obtained Der f II concentration, assuming that the Der f II concentration of the removed allergen extract is a and the Der f II concentration of the residual allergen extract is b, the allergen removal rate R by vacuum suction is as follows: Is defined by R = a / (a + b) × 100 (%) The above test was performed 5 times for each sample, and the average value of the obtained allergen removal rates for 5 times was defined as the allergen removal rate of the sample.

(2) Feeling evaluation method Sangetsu Carpet "SANSESEAL CL-10"
1 "was cut into a 10 cm square and used as a test piece. Spray the prescription liquid on the test piece at 0.1 cc / 100 cm ² and dry it sufficiently.
A sample was repeated 0 times. Ten panelists conducted sensory evaluation on the basis of the test piece which had not been treated, and the average value was obtained. 4 ... Tactile feeling is better than the standard 3 ... Equal to the standard 2 ... Tactile feeling is slightly inferior to the standard 1 ... Tactile feeling is obviously inferior to the standard

[0067]

[Table 1]

In Table 1, nonion means alkyl polyglucoside (alkyl group: carbon number 10 / carbon number 12 = 4/6).
(Mass ratio), glucose average degree of condensation 1.3), and the anion is alkenylsuccinic acid having 12 carbon atoms in the alkenyl group. The solubility of cedrol, camphene, myristyl alcohol, and thymol in water is 0.02g.
/ 100 g or less, solubility in component (a) is all 0.05 g / 100 g or more, moisture absorption is 0 to
It is within the range of 0.5.

The carpet treated without the composition of Table 1 with only a vacuum cleaner had an allergen removal rate of 21% and a feel evaluation of 3.5.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Masahiro Suzuki             Kao Co., Ltd. 1334 Minato, Wakayama City, Wakayama Prefecture             Inside the laboratory (72) Takeshi Ban             Kao Co., Ltd. 1334 Minato, Wakayama City, Wakayama Prefecture             Inside the laboratory (72) Inventor Michio Yokosuka             Kao Co., Ltd. 1334 Minato, Wakayama City, Wakayama Prefecture             Inside the laboratory F term (reference) 3B116 AA04 AB51 BA08 BB21

Claims (9)

[Claims] 1. (a) forming an azeotropic mixture with water;
1 to 70 mass% of an organic compound whose azeotropic temperature with water at 3.25 hPa is less than 100 ° C., (b) melting point is 25
0.001 to 5% by mass of an organic compound (excluding a surfactant and an organic acid) having a temperature of 0 ° C or higher, 0 to 5% by mass of an organic compound other than (c), (a) and (b), and (d) water. An allergen remover containing (b) / [(b) + (c)] in a mass ratio of 0.15 or more. 2. The solubility of (b) in water at 20 ° C. is 0.02 g / 100 g or less, and (b) 20 ° C.
2. The allergen remover according to claim 1, wherein the solubility in (a) is 0.05 g / 100 g or more. 3. The allergen removing agent according to claim 1, wherein the total of (a), (b), (c) and (d) is 95 to 100% by mass. 4. A method for removing an allergen, which comprises applying or spraying an aqueous solution containing an organic compound having a melting point of 25 ° C. or higher onto a target surface on which the allergen is present, and removing the organic compound including the allergen deposited after drying. 5. (a) forming an azeotropic mixture with water,
1 to 70 mass% of an organic compound whose azeotropic temperature with water at 3.25 hPa is less than 100 ° C., (b) melting point is 25
0.001 to 5% by mass of an organic compound (excluding a surfactant and an organic acid) having a temperature of 0 ° C or higher, 0 to 5% by mass of an organic compound other than (c), (a) and (b), and (d) water. Contains,
The allergen remover for use in the method according to claim 4, wherein (b) / [(b) + (c)] is 0.15 or more by mass ratio. 6. The solubility of (b) in water at 20 ° C. is 0.02 g / 100 g or less, and (b) 20 ° C.
The allergen remover according to claim 5, wherein the solubility in (a) in the above is 0.05 g / 100 g or more. 7. The allergen removing agent according to claim 5, wherein the total of (a), (b), (c) and (d) is 95 to 100% by mass. 8. (a) forming an azeotropic mixture with water,
1 to 70 mass% of an organic compound whose azeotropic temperature with water at 3.25 hPa is less than 100 ° C., (b) melting point is 25
0.001 to 5% by mass of an organic compound (excluding a surfactant and an organic acid) having a temperature of 0 ° C or higher, 0 to 5% by mass of an organic compound other than (c), (a) and (b), and (d) water. Contains, mites, chironomids, cockroaches and those carcasses or those feces that have become dust, broken pet hair,
An agent for removing pollen and at least one selected from mold spores. 9. (a) forming an azeotrope with water,
1 to 70 mass% of an organic compound whose azeotropic temperature with water at 3.25 hPa is less than 100 ° C., (b) melting point is 25 ° C.
Above organic compounds (excluding surfactants and organic acids)
0.001 to 5% by mass, (c) containing 0 to 5% by mass of an organic compound other than (a) and (b), and (d) water,
An aqueous solution in which (b) / [(b) + (c)] is 0.15 or more in a mass ratio is applied to the target surface on which the allergen is present, and the allergen is deposited together with the solid deposited by drying on the target surface. Of removing allergens from plants.