JP2003322610A - Optical device, specimen mounting component, light- emission-position controller, analytical system, person collation method and allergy and side-effect inspection method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an optical device which is miniaturized and which is made high-speed and low-cost and to provide a specimen mounting component, a light-emission-position controller, an analytical system, a person collation method and an allergy and side-effect inspection method. <P>SOLUTION: When light emitted from a light source 201a is guided to the y-direction, a polarization state of the light is modulated by a modulation part 201d using a liquid crystal so as to be emitted in a prescribed position in the y-direction, the light guided to the x-direction is modulated by a modulation part 202 using a liquid crystal so as to be emitted in a prescribed position in the x-direction, a specimen in a prescribed position on a specimen mounting part 204 is irradiated with the light, and signal light from the specimen is detected by a photodetector 206. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an optical device suitable for measuring an object to be measured, an object-to-be-measured object placement component, a light emission position control device, an analysis system, a person verification method, and allergy / side effects. It relates to the inspection method.

[0002]

2. Description of the Related Art Heretofore, various devices have been proposed for detecting the signal light emitted when a measured object is irradiated with light and measuring the property of the measured object.

As an object to be measured by such a device, for example, DNA can be mentioned. The technology for measuring DNA is part of genetic engineering, and this genetic engineering is used in the fields of agricultural and livestock such as genetically modified foods and cloned livestock,
It is used in environmental fields such as environmental restoration and waste processing using biotechnology, CO ₂ processing systems using biotechnology, and energy fields such as energy production using biomass. Of course, genetic engineering is used in fields other than the above.

For example, as a conventional method for analyzing a DNA chip, "a reading method and a reading device for a microarray chip" described in JP-A-2000-131237 and "Molecular organisms" described in JP-A-9-504910. Self-addressable, self-assembling small electronic systems and devices for biological analysis and diagnostics "and Tokkaihei 10-5127.
45, "DNA sequencing and D
NA identification method and apparatus ”.

[0005]

However, in the case of the prior art as described above, since the object to be measured is mechanically scanned, the driving unit for scanning is large and the entire apparatus becomes large. There is a problem that it ends up.

In addition, the conventional technique has a problem that it is difficult to reduce the scan time because the scan of the object to be measured is a mechanical scan.

Further, the conventional technique has a problem that the cost is increased due to the enlargement of the device and the increase in the number of parts.

The present invention has been made to solve the above-mentioned problems of the prior art. The object of the present invention is to reduce the size, increase the speed, and reduce the cost of an optical device and an object to be measured. An object of the present invention is to provide a mounting component, a light emission position control device, an analysis system, a personal identification method, and an allergy / side effect inspection method.

[0009]

In order to achieve the above object, an optical device according to the present invention comprises a light source means for emitting light,
Polarization conversion means for converting the polarization state of the light from the light source means, first light guide means for guiding the light emitted from the polarization conversion means in a first direction, and the first light guide means. A first modulation means for modulating the polarization state of the light guiding the light at a predetermined position in the first direction, and a polarization state of the light formed on the surface of the first light guiding means. First transmission / reflection control means for controlling transmission and reflection of light according to the first transmission means; second light guide means for guiding the light transmitted through the first reflection / transmission control means in a second direction; Second modulation means for modulating the polarization state of the light guided through the second light guiding means at a predetermined position in the second direction, and formed on the surface of the second light guiding means. Second transmission / reflection control means for controlling transmission and reflection of light according to the polarization state of the light; and the second reflection / transmission control means. And the measured body mounting means for mounting the object to be measured to light transmitted through the device is irradiated, characterized in that it comprises a light receiving means for receiving light emitted from said object to be measured.

Further, the optical device according to the present invention comprises the first
Of the first liquid crystal layer and a surface of the first liquid crystal layer, wherein the first light guide means is formed. A first reflecting means formed on a surface opposite to the side surface, and by applying a voltage to the liquid crystal cell at a predetermined position in the first direction, the polarization state of the light is changed to the first surface. It is characterized by modulating at a predetermined position in the direction.

The optical device according to the present invention is the optical device according to the second aspect.
Is a second liquid crystal layer formed of liquid crystal cells arranged in the second direction, and the surface of the second liquid crystal layer, and the second light guide means is formed. A second reflection means formed on a surface opposite to the side surface, and applying a voltage to the liquid crystal cell at a predetermined position in the second direction changes the polarization state of the light to the second surface. It is characterized by modulating at a predetermined position in the direction.

Further, the optical device according to the present invention comprises the first
At least one of the liquid crystal of the first liquid crystal layer forming the modulating means or the liquid crystal of the second liquid crystal layer forming the second modulating means is formed into a first alignment film and a second alignment film. Sandwiched between
The twist angle between the first alignment film and the second alignment film is 45 °.

The optical device according to the present invention includes a light source means for emitting light, a first light guide means for guiding the light emitted from the light source means in a first direction, and the first direction. A surface of the first modulating means for allowing the light guided through the first light guiding means to enter by modulating the refractive index at a predetermined position of First
Formed on the surface opposite to the side on which the light guide means is formed,
First reflecting means for reflecting the light incident on the first modulating means to the first light guiding means side, and guiding the light emitted from the first light guiding means in the second direction. A second light guide means, and a second modulator means for allowing the light guided through the second light guide means to enter by modulating the refractive index at a predetermined position in the second direction. The light incident on the second modulation means, which is formed on the surface of the second modulation means opposite to the side on which the second light guide means is formed, receives the light incident on the second modulation means. Second reflecting means for reflecting to the light guide means side, object-to-be-measured placing means for placing the object to be measured irradiated with the light emitted from the second light guide means, and emitting from the object to be measured. And a light receiving means for receiving the received light.

Further, the optical device according to the present invention comprises the first
The modulating means includes a first liquid crystal layer composed of a plurality of liquid crystal cells arranged in the first direction, and by applying a voltage to the liquid crystal cells at a predetermined position in the first direction,
The refractive index of the liquid crystal cell is modulated at a predetermined position in the first direction.

The optical device according to the present invention is the optical device according to the second aspect.
The modulating means includes a second liquid crystal layer composed of a plurality of liquid crystal cells arranged in the second direction, and by applying a voltage to the liquid crystal cells at a predetermined position in the second direction,
It is characterized in that the refractive index of the liquid crystal cell is modulated at a predetermined position in the second direction.

Further, the optical device according to the present invention is characterized in that the light source means for emitting light, the polarization conversion means for converting the polarization state of the light from the light source means, and the light emitted from the polarization conversion means are the first. First light guiding means for guiding light in a direction, and the first
First modulating means for modulating the polarization state of light guided through the light guiding means at a predetermined position in the first direction, and light formed on the surface of the first light guiding means. First transmission / reflection control means for controlling the transmission and reflection of light in accordance with the polarization state of the second light guide means, and second light guiding means for guiding the light transmitted through the first reflection / transmission control means in the second direction. And the second
Planes of the second modulating means and the second modulating means for allowing the light guided through the second light guiding means to enter by modulating the refractive index at a predetermined position in the direction of. , A second reflection formed on a surface opposite to the side where the second light guide means is formed, for reflecting the light incident on the second modulator means to the second light guide means side. Means and said second
The object-to-be-measured mounting means for mounting the object-to-be-measured on which the light emitted from the light guide means is irradiated, and the light-receiving means for receiving the light emitted from the object-to-be-measured.

The optical device according to the present invention includes a light source means for emitting light, a first light guide means for guiding the light emitted from the light source means in a first direction, and the first direction. A surface of the first modulating means for allowing the light guided through the first light guiding means to enter by modulating the refractive index at a predetermined position of First
Formed on the surface opposite to the side on which the light guide means is formed,
First reflecting means for reflecting the light incident on the first modulating means to the first light guiding means side, and guiding the light emitted from the first light guiding means in the second direction. A second light guide means, a polarization conversion means for converting a polarization state of light arranged at any position of a light path from the light source means to the second light guide means, and the second light guide means. Second modulation means for modulating the polarization state of the light guided through the light means at a predetermined position in the second direction, and polarization of the light formed on the surface of the second light guide means. Second transmission / reflection control means for controlling transmission and reflection of light in accordance with the state, and measurement object mounting means for mounting the measurement object irradiated with the light transmitted through the second reflection / transmission control means. And a light receiving means for receiving the light emitted from the object to be measured.

Further, the optical device according to the present invention comprises the same number of light source means arranged in the first direction as the number of the measured object placement portions in the first direction of the measured object placement means. A polarization conversion unit that converts the polarization state of light from the light source unit, a second light guide unit that guides the light from the polarization conversion unit in a second direction, and a second light guide unit. Depending on the polarization state of light formed on the surface of the second modulation means and the second light guide means for modulating the polarization state of the radiated light at a predetermined position in the second direction. Second transmission / reflection control means for controlling the transmission and reflection of light; and an object-to-be-measured mounting means for mounting an object to be measured irradiated with the light transmitted through the second reflection / transmission control means; And a light receiving means for receiving the light emitted from the measuring object.

The optical device according to the present invention is the optical device according to the second aspect.
Is a second liquid crystal layer formed of liquid crystal cells arranged in the second direction, and the surface of the second liquid crystal layer, and the second light guide means is formed. A second reflection means formed on a surface opposite to the side surface, and applying a voltage to the liquid crystal cell at a predetermined position in the second direction changes the polarization state of the light to the second surface. It is characterized by modulating at a predetermined position in the direction.

The optical device according to the present invention is the optical device according to the second aspect.
The liquid crystal of the second liquid crystal layer constituting the modulation means is sandwiched between the first alignment film and the second alignment film, and the twist angle between the first alignment film and the second alignment film is 45 °. It is characterized by being.

Further, the optical device according to the present invention comprises light source means arranged in the first direction, the number of which is the same as the number of the measured object placement portions in the first direction of the measured object placing means. A second light guide for guiding light emitted from the light source means in a second direction;
Light guide means, a second modulator means for causing the light guided through the second light guide means to enter by modulating the refractive index at a predetermined position in the second direction, and Two
The second light guide means formed on the surface of the modulation means of the second light guide means opposite to the side on which the second light guide means is formed and which reflects the incident light toward the second light guide means. Reflection means and the second
The object-to-be-measured mounting means for mounting the object-to-be-measured on which the light emitted from the light guide means is irradiated, and the light-receiving means for receiving the light emitted from the object-to-be-measured.

Further, the optical device according to the present invention comprises the second
The modulating means includes a second liquid crystal layer composed of a plurality of liquid crystal cells arranged in the second direction, and by applying a voltage to the liquid crystal cells at a predetermined position in the second direction,
It is characterized in that the refractive index of the liquid crystal cell is modulated at a predetermined position in the second direction.

Further, in the optical device according to the present invention, the light receiving means may guide the light emitted from the object to be measured.
The light guide means and the light detection means for detecting the light guided through the third light guide means.

Further, in the optical device according to the present invention, the light receiving means can independently measure light emitted from a plurality of measured objects on the measured object placing means.
It is characterized by being configured by a D (charge-coupled device).

In the optical device according to the present invention, the first device for condensing the light irradiated to the object to be measured on the object to be measured placing means is provided below the object to be measured placing means. It is characterized in that it is provided with a light collecting means.

In the optical device according to the present invention, the second device for condensing the light emitted from the object to be measured on the object to be measured placing means on the upper part of the object to be measured placing means. It is characterized in that it is provided with a light collecting means.

Further, in the optical device according to the present invention, the surface of the object-to-be-measured mounting means opposite to the surface on which the object-to-be-measured is placed is irradiated with the light irradiated to the object-to-be-measured. It is characterized in that a third light collecting means for collecting light is formed.

Further, the optical device according to the present invention is provided with a cover portion for covering the surface of the object-to-be-measured mounting means opposite to the surface on which the object to be measured is mounted, and the material of the cover part. Is different from the refractive index of the material of the portion where the third condensing means is formed.

Further, in the optical device according to the present invention, the measured object placing means is provided in at least one of the measured object placing means and the second light guiding means and the second modulating means. A first positioning means for positioning in the plane direction of is formed.

Further, the optical device according to the present invention is for positioning between the measured object placing means and the second light guide means in a direction perpendicular to the surface of the measured object placing means. The second positioning means is formed.

Further, the optical device according to the present invention comprises the second
The light guiding means, the second modulating means, and the object-to-be-measured placing means are fixed to each other by fixing means formed between them.

The optical device according to the present invention is the optical device according to the second aspect.
At least one of a fixing means formed between the light guiding means and the second modulating means and a fixing means formed between the second light guiding means and the measured object placing means. It is characterized by being formed of a material that releases the fixation of the upper and lower parts when heat is applied.

Further, in the optical device according to the present invention, the measuring object placing means is a glass substrate, and the measuring object is DN.
It is characterized by being an A probe.

Furthermore, the object-to-be-measured mounting part according to the present invention is characterized in that it is used in the above-described optical device which functions as a device-to-be-measured object mounting means on which a material to be measured is mounted.

Further, the light emission position control device according to the present invention includes a polarization conversion means for converting the polarization state of the light from the light source means, and a guide for guiding the light emitted from the polarization conversion means in a predetermined direction. Formed on the surface of the light guide means, a modulator for modulating the polarization state of the light guided through the light guide means at a predetermined position in the predetermined direction,
A transmission / reflection control unit that controls transmission and reflection of light according to a polarization state of light, wherein the modulation unit includes a liquid crystal layer including a plurality of liquid crystal cells arranged in the predetermined direction, and a surface of the liquid crystal layer. And a reflection means formed on a surface opposite to the surface on which the light guide means is formed, and by applying a voltage to the liquid crystal cell at the predetermined position,
The polarization state of the light is modulated at a predetermined position in the predetermined direction.

Further, the light emission position control device according to the present invention, the light guide means for guiding the light emitted from the light source means in a predetermined direction, and the refractive index is modulated at a predetermined position in the predetermined direction. Thereby, the modulation means for allowing the light guiding the light guiding means to enter, and the surface of the modulation means, which is formed on the surface opposite to the side on which the light guiding means is formed, A reflecting means for reflecting the light incident on the modulating means to the light guide means side, wherein the modulating means comprises a liquid crystal layer composed of a plurality of liquid crystal cells arranged in the predetermined direction,
The refractive index of the liquid crystal cell is modulated at a predetermined position in the predetermined direction by applying a voltage to the liquid crystal cell at a predetermined position in the predetermined direction.

Furthermore, the analysis system according to the present invention comprises the above-mentioned optical device, and storage means for storing comparison information for comparison with the measurement information output from the optical device.
It is characterized by comprising an analysis device for analyzing the object to be measured based on the measurement information output from the optical device and the comparison information stored in the storage means.

Further, the personal identification method according to the present invention is the personal identification method using the above-mentioned analysis system, wherein the optical device measures the gene information of the user to obtain measurement information, and the storage means stores the personal information. Is stored as comparison information, the analysis device performs matching of the person based on the gene information measured by the optical device and the gene information indicating the person stored in the storage means. Characterize.

Furthermore, the allergy / side effect test method according to the present invention uses the above-mentioned analysis system.
A side effect inspection method, wherein the optical device measures genetic information of a user to obtain measurement information, and group information that causes allergies / side effects is stored as comparison information in the storage means, It is characterized in that the allergy / side effect is tested based on the gene information measured by the device and the group information storing the allergy / side effect stored in the storage means.

[0040]

BEST MODE FOR CARRYING OUT THE INVENTION Preferred embodiments of the present invention will be illustratively described in detail below with reference to the drawings. However, the dimensions of the components described in this embodiment,
Unless otherwise specified, the material, the shape, the relative arrangement, and the like are not intended to limit the scope of the present invention thereto.

Further, in the following drawings, the same parts as those described in the above drawings are designated by the same reference numerals.

(Outline of Embodiment of Optical Device According to the Present Invention) Before explaining each embodiment of the optical device according to the present invention, an outline of the embodiment of the optical device according to the present invention will be described with reference to FIG. Explain. FIG. 1 is a schematic diagram for explaining an outline of an embodiment of an optical device according to the present invention.

As shown in FIG. 1, the optical device according to the present invention includes an incident section 101, a modulation section 102, a light guide section 103,
The measured object placement unit 104 and the light receiving unit 105 are configured as main components. Of course, in each embodiment, parts other than the parts shown in FIG. 1 may be added.

Further, in the example shown in FIG. 1, a state in which the respective parts are widely separated is shown, but this is for convenience of description, and in the optical device according to the present invention, the respective parts are widely separated. It is not necessary that each component be in close contact with the upper and lower components or be arranged with a proper distance. This point is the same in each embodiment described below.

The incident section 101 is a component that emits light incident on the light guide section 103, and is composed of an LED, a modulation section for selecting a position where the light is emitted in the direction 2, and the like.

The modulator 102 is a component for selecting the emission position of the light guided in the light guide 103 in the direction 1.

The light guide section 103 is a component for guiding the light emitted from the incident section 101 in a direction parallel to the direction 1.

The object-to-be-measured mounting portion 104 is a component for mounting the object-to-be-measured, which is irradiated with the light emitted from the light guide portion 103.

The light receiving section 105 is a part for receiving the light emitted from the object to be measured which is irradiated with light. For example, a part combining a light guide part and a photodetector or a CCD (char
ge-coupled device).

In FIG. 1, direction 1 and direction 2 are defined. In the following embodiments, the direction 1 and the direction 2 may correspond to the orthogonal x direction and y direction, respectively. However, these directions correspond to the position of the measured object on the measured object placing portion 104 by two. Since it is a direction for dimensionally specifying, the directions 1 and 2 are not limited to the cases corresponding to the orthogonal x direction and y direction, and may be directions non-parallel to each other.

Further, the following embodiments are embodiments in which the above-mentioned respective parts are modified and combined, and embodiments in which the above-mentioned respective parts are further combined with other parts.

For example, in the first embodiment of the optical device according to the present invention described below, the incident section 101 and the modulation section 10 are provided.
In the second embodiment of the optical device according to the present invention, the polarization state of light is modulated by using a liquid crystal layer 2 to control the emission position of the light irradiated to the measured object. Part 10
The liquid crystal layer 2 is used to modulate the reflection (refraction) state of the light guided through the light guide unit 103 to control the emission position of the light with which the measured object is irradiated.

However, the present invention is not limited to the optical device as in the first and second embodiments, and for example, the polarization state of light is changed by the liquid crystal in the incident section 101. The light emission position is controlled by changing the light emission position of the light to be measured by modulating the reflection (refraction) state of the light guided through the light guide unit 103 by the liquid crystal in the modulation unit 102. When controlling, or vice versa, both the modulation of the polarization state of light and the modulation of the reflection (refraction) state of light are used in an arbitrary combination to control the emission position of light. Is also good.

In the following description of each embodiment of the optical device according to the present invention, the description of the incident portion 101 or the portion corresponding to the modulation portion 102 and the light guide portion 103 is related to the present invention. It also serves as a description of each embodiment of the light emission position control device.

In the description of each embodiment of the optical device according to the present invention, which will be described below, the object-to-be-measured part 10 is placed.
The description of the part corresponding to 4 also serves as the description of each embodiment of the measured object placement component according to the present invention.

(First Embodiment of Optical Device) Next, a first embodiment of the optical device according to the present invention will be described with reference to FIGS. FIG. 2 is an overall schematic view of the first embodiment of the optical device according to the present invention.

As shown in FIG. 2, the first embodiment of the optical device according to the present invention comprises a light source 201a which emits light,
A polarization conversion element 201b that converts the polarization state of the light emitted from the light source 201a.

In the first embodiment of the optical device according to the present invention, the light guide section 201c for guiding the light emitted from the polarization conversion element 201b and the light guide section 201c for guiding the light. And a modulator 201d for modulating the polarization state.

The first embodiment of the optical device according to the present invention shown in FIG. 2 includes a modulator 202 for modulating the polarization state of light guided through the light guide 203, and a light guide. Part 2
Light guide part 203 for guiding the light emitted from 01c.
With.

In the first embodiment of the optical device according to the present invention shown in FIG. 2, the measured object placing portion on which the measured object irradiated with the light emitted from the light guide section 203 is placed. 204
Equipped with.

In the first embodiment of the optical device according to the present invention shown in FIG. 2, the light guide section 205 for guiding the light emitted from the object to be measured and the light guide section 205 are guided. And a photodetector 206 for receiving the emitted light.

The light source 201a is, for example, a semiconductor laser, L
It is composed of an ED or the like and emits predetermined light.

The polarization conversion element 201b converts the polarization state of the light emitted from the light source 201a into, for example, P wave or S wave.

The light guide portion 201c and the modulation portion 201d are y
The emission position in the y direction of the light directed in the direction is controlled. This control operation will be described later.

The light guide section 201c includes the light guide section 201c.
An angle imparting portion 201c-1 for forming an angle on the light guided inside the c is formed.

The light emitted from the light source 201a is guided inside the light guide portion 201c by the angle imparting portion 201c-1 with a reflection pattern as shown in FIG. 3, for example.

Therefore, the reflection pattern of light inside the light guide portion 201c can be controlled by the angle imparting portion 201c-1.

Of course, the light guide portion 201 is formed by inclining the light source 201a without forming the angle imparting portion 201c-1.
You may control the reflection pattern of the light inside c.

The modulator 202 and the light guide 203 control the emission position in the x direction of the light traveling in the x direction. This control operation will be described later.

The light guide section 203 has an angle giving section 20 for making an angle to the light guided inside the light guide section 203.
3-1 is formed.

The light emitted from the light guide portion 201c is guided by the angle imparting portion 203-1 through the inside of the light guide portion 203 with a reflection pattern as shown in FIG.

Therefore, the reflection pattern of light inside the light guide portion 203 can be controlled by the angle imparting portion 203-1.

Of course, the light guide portion 203c is formed by inclining the light guide portion 201c without forming the angle imparting portion 203-1.
You may control the reflection pattern of the light inside.

The object-to-be-measured mounting portion 104 mounts the object-to-be-measured.

The light guide section 205 is a photodetector 20 configured by a photodiode or the like for the light emitted from the object to be measured.
Guide light to 6. In the example shown in FIG. 2, the light guide unit 205
Is a light guide section in which two wedge-shaped light guide sections are combined, but the light guide section applied to the present embodiment is not limited to such a wedge-shaped light guide section. ,
For example, it is possible to use a suitable light guide part such as a light guide part in which a pattern for guiding light is formed on the surface.

(Ejection Position Control Operation) Next, with reference to FIGS. 3 and 4, the light emission position control operation in the light guide section 201c and the modulation section 201d, and the light in the modulation section 202 and the light guide section 203 will be described. Each of the control operations of the emission position of is described.

FIG. 3 is an enlarged sectional view of the portion A shown in FIG. 2, and FIG. 4 is an enlarged sectional view of the portion B shown in FIG.

First, the portion A shown in FIG. 2 is shown in FIG.
Will be described with reference to. As shown in FIG. 3, the light guide unit 2
01c and the modulation unit 201d are composed of a reflection plate 301 formed of a mirror, a liquid crystal layer 302, a light guide unit 303, and a Bragg grating pattern 304 formed on the surface of the light guide unit 303.

The liquid crystal layer 302 has a plurality of liquid crystal cells 305 divided in the y direction, and ON / OFF of the liquid crystal cells 305 can be controlled independently.

Here, turning on and off the liquid crystal cell means changing the molecular alignment and changing the light alignment surface by applying a voltage to the liquid crystal cell.

Bragg grating pattern 3
04 has a property of transmitting only one of S-wave and P-wave polarization and reflecting the other. In the case of this embodiment, the Bragg grating pattern 304 that transmits P waves is used. However, if matching is achieved in the entire embodiment, a Bragg grating pattern that transmits S waves may be used.

In the laminated structure shown in FIG. 3,
The direction in which the Bragg grating pattern 304 is formed is the direction toward the light guide portion 203 in FIG.

Next, the operation until the light emitted from the light source 201a is emitted from the Bragg grating pattern 304 shown in FIG. 3 will be described with reference to FIGS.

First, light is emitted from the light source 201a.
In this case, the polarization directions of the emitted light are not uniform.

Next, the light source 2 is converted by the polarization conversion element 201b.
The polarization directions of the light emitted from 01a are aligned (here, they are aligned with the S wave).

Next, the light that has passed through the polarization conversion element 201b enters the light guide portion 201c as it is.

As shown in FIG. 3, the light incident on the light guide portion 303 is guided while being repeatedly reflected between the reflection plate 301 and the Bragg grating pattern 304 formed on the opposite surface of the light guide portion 303. To go.

Specifically, when the liquid crystal cell is in the ON state,
The polarization direction does not change even after passing through the liquid crystal layer 302, and the S wave remains.

Therefore, the light traveling through the light guide section 303 is
The light is reflected by the reflection plate 301, returns to the light guide portion 303, and reaches the Bragg grating pattern 304.

On the other hand, when the liquid crystal cell is in the OFF state, the polarization state of the light that has entered the liquid crystal cell from the light guide section 303, is reflected by the reflection plate 301, and is emitted to the light guide section 303 again is determined by the liquid crystal layer 302. It is converted into P waves by the polarization effect.

Therefore, if the Bragg grating pattern 304 is formed so as to reflect in the case of the S wave and transmit in the case of the P wave, the light having the polarization state of the S wave is guided while being repeatedly reflected as it is. The P-wave light can be emitted from a desired position in the y direction of the Bragg grating pattern 304 by turning on the liquid crystal cell at the desired position.

Further, if the light guide section 303 and the liquid crystal layer 302 have the same refractive index, Fresnel loss and the like can be reduced.

Here, the liquid crystal layer 302 is sandwiched between the first alignment film and the second alignment film, and the twist angle between the first alignment film and the second alignment film is 45 °. desirable.

Next, regarding the part B shown in FIG.
Will be described with reference to. As shown in FIG. 4, the modulator 2
02 and the light guide portion 203 are a reflection plate 401 formed of a mirror or the like, a liquid crystal layer 402 formed of liquid crystal cells 405, a light guide portion 403, and a Bragg grating pattern 404 formed on the surface of the light guide portion 403. Composed of. Also, the Bragg grating pattern 40
4, the object-to-be-measured placement part 4 on which the object-to-be-measured 407 is placed.
06 is provided.

That is, the structure of the part B is substantially the same as the structure of the part A described with reference to FIG. 3, and the operation thereof is also substantially the same. Therefore, in the following description, a part different from the above description of FIG. 3 will be mainly described.

In the portion B, the light emitted from the Bragg grating pattern 304 shown in FIG.
Since the light is polarized into waves, the Bragg grating pattern 404 is a Bragg grating pattern 404 that transmits S waves and reflects P waves. However, if matching is achieved in the entire embodiment, a Bragg grating pattern that transmits P waves may be used.

Then, similarly to the operation of the portion A, the operation of the portion B controls ON / OFF of the liquid crystal layer 402 to control the position of the light emitted in the x direction.

Further, the liquid crystal layer 402 is sandwiched between the first alignment film and the second alignment film, and the twist angle between the first alignment film and the second alignment film is preferably 45 °. .

Then, the light emitted from the Bragg grating pattern 404 is applied to the measured object 407 on the measured object placing portion 406.

Here, the relationship between the emission position of the light selected by the modulator and the position of the measured object on the measured object placing section will be described with reference to FIG. FIG. 5 is a schematic diagram of the relationship between the emission position of the light selected by the modulator and the position of the measured object on the measured object placing section in the optical device shown in FIG.

As shown in FIG. 5, the object mounting plate portion 505 is divided into a plurality of measured cells 503 for mounting the object to be measured. The position of the measured cell 503 can be uniquely specified by designating the respective positions in the x direction and the y direction.

The modulation section 501 and the modulation section 502 are each divided into a plurality of positions, and the position corresponding to this position can be the light emission position.

Therefore, when the structure shown in FIGS. 3 and 4 is taken as an example, when it is desired to irradiate light to the object to be measured at the position (m, n) as shown in FIG. Of only the n-th liquid crystal cell 501a of the liquid crystal layer
Let it be F.

Also in the x direction, similarly, only the m-th liquid crystal cell 502a is turned off.

Therefore, the light is emitted only to the object to be measured in the cell to be measured at the position (m, n).

Next, the irradiated object to be measured emits signal light with the irradiation light as reference light. Examples of such an object to be measured include fluorescent molecules in a DNA chip.

Then, as shown in FIG. 2, the radiated signal light is transmitted through the light guide section 205 provided on the upper part of the object to be measured.
The light is guided through the inside and finally reaches the photodetector 206 such as a photodiode.

As described above, since mechanical scanning has been conventionally performed, each component for driving is required and the entire apparatus is enlarged. However, in the present embodiment, since the scanning is electrically performed, it is significantly large. It is possible to realize compact size.

Further, in this embodiment, the cost can be reduced as the number of parts is reduced and the size is reduced.

Further, in the present embodiment, the mechanical scanning is changed to the electrical scanning, so that the time required for the measurement can be significantly reduced.

(Second Embodiment of Optical Device) Next, a second embodiment of the optical device according to the present invention will be described with reference to FIGS.
2 will be described.

FIG. 6 is an overall schematic view of a second embodiment of the optical device according to the present invention. As shown in FIG. 6, the second embodiment of the optical device according to the present invention includes a light source 601a that emits light. In addition, in this embodiment, the polarization conversion element 201b is not required as in the above-described first embodiment.

In the second embodiment of the optical device according to the present invention, the light guide section 601c for guiding the light emitted from the light source 601a and the light guide section 60 by modulating the refractive index.
And a modulator 601b for controlling the emission position of the light guided through 1c.

In the second embodiment of the optical device according to the present invention shown in FIG. 6, the light guide section 603 for guiding the light emitted from the light guide section 201c and the refractive index are modulated. Accordingly, a modulator 602 for controlling the emission position of the light guided through the light guide 603 is provided.

In the second embodiment of the optical device according to the present invention shown in FIG. 6, the measured object placing part on which the measured object irradiated with the light emitted from the light guide section 603 is placed. 604
Equipped with.

In the second embodiment of the optical device according to the present invention shown in FIG. 6, the light guide section 605 for guiding the light emitted from the object to be measured and the light guide section 605 are guided. And a photodetector 606 including a photodiode or the like for receiving the emitted light.

The light source 601a is, for example, a semiconductor laser, L
It is composed of an ED or the like and emits predetermined light.

The light guide 601c and the modulator 601b are y
The emission position in the y direction of the light directed in the direction is controlled. This control operation will be described later.

The light guide section 601c includes a light guide section 601.
An angle imparting portion 601c-1 for forming an angle on the light guided inside the c is formed.

The light emitted from the light source 601a is guided by the angle imparting section 601c-1 inside the light guide section 601c with a reflection pattern as shown in FIG. 7, for example.

Therefore, the reflection pattern of light inside the light guide section 601c can be controlled by the angle giving section 601c-1.

Of course, the light guide section 601 can be formed by tilting the light source 601a without forming the angle imparting section 601c-1.
You may control the reflection pattern of the light inside c.

The modulation section 602 and the light guide section 603 control the emission position in the x direction of light traveling in the x direction. This control operation will be described later.

The light guide section 603 has an angle imparting section 60 for making an angle to the light guided inside the light guide section 603.
3-1 is formed.

The light emitted from the light guide portion 601c is guided by the angle imparting portion 603-1 through the light guide portion 603 with a reflection pattern as shown in FIG. 9, for example.

Therefore, the reflection pattern of light inside the light guide portion 603 can be controlled by the angle imparting portion 603-1.

Of course, the light guide portion 603 is formed by inclining the light guide portion 601c without forming the angle imparting portion 603-1.
You may control the reflection pattern of the light inside.

The object-to-be-measured mounting portion 604 mounts the object-to-be-measured.

The light guide section 605 guides the light emitted from the object to be measured to the photodetector 606. In the example shown in FIG. 6, the light guide section 605 is a light guide section in which two wedge-shaped light guide sections are combined, but such a wedge shape is used as the light guide section applied to the present embodiment. The light guide unit is not limited to the mold, and other suitable light guide units may be used.

(Exiting Position Control Operation) Next, FIGS.
9 and FIG. 9, the modulation unit 601b and the light guide unit 601.
Each of the control operation of the light emission position in c and the control operation of the light emission position in the modulation unit 602 and the light guide unit 603 will be described.

FIG. 7 is an enlarged cross-sectional view of the portion C shown in FIG. 6, FIG. 8 is a schematic view of a birefringence structure of liquid crystal molecules used for the liquid crystal layer of this embodiment, and FIG. [Fig. 7] is an enlarged cross-sectional view of a portion D shown in Fig. 6.

First, the portion C shown in FIG. 6 is shown in FIG.
Will be described with reference to. As shown in FIG. 7, the modulator 6
01 b and the light guide portion 601 c are composed of a reflection film 701 formed by a mirror or the like, a liquid crystal layer 702, and a light guide portion 703.

The liquid crystal layer 702 has a plurality of liquid crystal cells 705 divided in the y direction.
ON and OFF can be controlled independently.

Here, turning on and off of the liquid crystal cell is the same as in the case of the first embodiment of the optical device according to the present invention described above.

In the laminated structure shown in FIG. 7,
The direction in which the light guide portion 703 is formed is the direction toward the light guide portion 603 in FIG.

Next, the operation until the light emitted from the light source 601a is emitted from the light guide portion 703 shown in FIG. 7 will be described with reference to FIGS. 6 and 7.

First, light is emitted from the light source 601a.
In this case, the polarization directions of the emitted light are not uniform. The light from the light source 601a directly enters the light guide unit 601c.

As shown in FIG. 7, the light incident on the light guide portion 703 is guided while being repeatedly reflected between the surface of the liquid crystal layer 702 and the surface of the light guide portion 703 on the light guide portion 603 side. Go.

On the other hand, the liquid crystal molecules constituting the liquid crystal layer 702 have a birefringence structure, and by turning on the liquid crystal, the refractive index of the liquid crystal cell 705 at that portion should be made larger than that when it is off. You can

As shown in FIG. 8, assuming that the refractive index of liquid crystal molecules is ne and no, Δn = ne-no.
In some cases, ≈0.13. Of course, Δn is an example, and other values can be taken.

Therefore, the refractive index of the light guide portion 703 and the incident angle of the light to be guided are determined so that the light is changed from reflected to transmitted at the boundary between the light guide portion 703 and the liquid crystal layer 702 due to the change of the refractive index. In other words, light is transmitted through only the portion where the liquid crystal cell is turned on and enters the liquid crystal layer 702.

The light incident on the liquid crystal layer 702 is converted into the liquid crystal layer 702.
It is incident on the reflection film 701 formed on the substrate.

An uneven pattern is formed on the reflection film 701.

Next, the light reflected by the reflection film 701 is re-incident on the light guide portion 703, and the light guide portion 6 of the light guide portion 703.
It is transmitted without being reflected by the surface on the 03 side.

This is because the concave-convex pattern of the reflection film 701 limits the angle of incidence of light on the surface of the light guide portion 703 on the light guide portion 603 side so as not to be reflected.

Therefore, by controlling ON / OFF of the desired liquid crystal cell 705 of the liquid crystal layer 702, the light emission position in the y direction can be controlled.

Next, regarding the part D shown in FIG. 6, FIG.
Will be described with reference to. As shown in FIG. 9, the liquid crystal layer 7
02 and the light guide portion 703 are the reflection film 901.
And a liquid crystal layer 902 including a liquid crystal cell 905, and a light guide section 9
And 03. Further, on the light guide section 903, a measured object placement section 904 on which the measured object 906 is placed is provided.

That is, the structure of the portion D is substantially the same as the structure of the portion C described with reference to FIG. 7, and the operation thereof is also substantially the same.

Similarly to the operation of the portion C, the operation of the portion D controls ON / OFF of the liquid crystal layer 902 to control the position of the light emitted in the x direction.

Then, the light emitted from the light guide section 903 is applied to the measured object 906 on the measured object placing section 904.

Then, the light emitted from the object to be measured is guided through the light guide section 605 as shown in FIG.
It is detected by the photodetector 606.

Therefore, also in this embodiment, as in the first embodiment of the optical device according to the present invention, the object to be measured located at (m, n) on the object mounting portion can be easily measured. Light can be emitted and the detection can be performed.

Next, the reflection film 701 shown in FIG. 7 and FIG.
Alternatively, the manufacturing method of the uneven shape of the reflection film 901 will be described with reference to FIG.
From now on, description will be made with reference to FIG.

Since the reflection film 701 or the reflection film 901 shown in FIGS. 7 and 9 is formed as a film on the reflection plate, a method for manufacturing the reflection plate will be described below.

The uneven shape of the reflection plate can be reproduced in a large amount by using a die called a stamper. The 2P method, which is the manufacturing method thereof, will be described with reference to FIGS. 10 and 11.
10 and 11 are process diagrams of a method for manufacturing the uneven shape of the reflection plate including the reflection film used in the second embodiment of the optical device according to the present invention by the 2P method.

In the case of manufacturing a reflection plate, as shown in FIG. 10, (a) a substrate 1001 is prepared, and an electron beam resist 1002 is applied thereon.

Next, (b) in order to form a convex shape, the resist 1002 is finely processed by an electron beam to manufacture an uneven master disk 1003.

Next, (c) a stamper material such as nickel is deposited on the master 1003 by the electroforming method to form the stamper 1
004 is produced.

Next, (d) stamper 1004 and master 10
Separate from 03. The stamper 1004 has a concave shape corresponding to the convex shape, and is a concave-convex mold.

Next, as shown in FIG. 11E,
After the master 1003, which is a model of the reflector, is created, the stamper 1004 is manufactured by the electroforming method.
4 has an inverted pattern 1004a of the surface shape of the reflector.

Then, an ultraviolet curable resin 1005 is dropped on a transparent substrate 1001 such as a glass substrate or a transparent resin film (however, the substrate 1001 need not be transparent when the stamper transmits ultraviolet rays). After that, the stamper 1004 is lowered onto the substrate 1001 from above the ultraviolet curable resin 1005, and the substrate 1001 and the stamper 100
Substrate 1
Between the 001 and the stamper 1004, the UV curable resin 10
Fill with 05.

Then, as shown in FIG.
The ultraviolet curable resin 1005 is irradiated with ultraviolet rays from one side, and the ultraviolet curable resin 1005 is cured by a photocuring reaction.
After the UV curable resin 1005 is cured, the stamper 1004 is peeled off from the UV curable resin 1005.
The surface of the UV curable resin 1005 is
Inversion pattern 1004a of 004 is inverted to form pattern 1
It is transferred as 005a.

Thereafter, a metal thin film of Ag, Al or the like is deposited on the pattern 1005a of the ultraviolet curable resin 1005 by sputtering or the like, and as shown in FIG.
006 is formed, and thereby the reflector 1008 is completed.

Next, as another method for manufacturing the above-mentioned reflector, a manufacturing method by the embossing method will be described with reference to FIG. FIG. 12 is a process diagram of a method for manufacturing an uneven shape of a reflection plate including a reflection film used in the second embodiment of the optical device according to the present invention by an embossing method.

As shown in FIG. 10D, a master 1003, which is a model of a reflector, is prepared, and then a stamper 1004 is prepared by electroforming. The stamper 1004 has an inverted pattern of the reflector surface shape. 1004a is formed

Then, after resin 1009 such as acrylic resin is spin-coated on the substrate 1001 shown in FIG. 12 (i), the resin 1009 is formed as described in (j).
The stamper 1004 is lowered from above and the resin 1009 is pressed.

By this pressing, the resin 10 as shown in FIG.
The reverse pattern 100 of the stamper 1004 on the surface of 09
4a is inverted and transferred as a pattern 1009a.

Thereafter, the pattern 1009 of the resin 1009 is formed.
A thin metal film of Ag, Al, or the like is deposited on a by sputtering, and a reflection film 1006 is formed as shown in (l), whereby the reflection plate 1008 is completed.

The above is the description of the method of manufacturing the reflective film in the second embodiment of the optical device according to the present invention. However, the reflective film of the optical device according to the present invention is not limited to the case of being manufactured by the manufacturing method as described above, and can be manufactured by other appropriate methods.

Thus, the second optical device according to the present invention is
In the embodiment, the same effects as those of the first embodiment of the optical device according to the present invention described above can be obtained, and since the polarization direction of light does not matter, an optical element such as a change conversion element or a Bragg grating is used. It becomes unnecessary and further cost reduction is possible.

Here, as described above, in the optical device according to the present invention, the method for controlling the emission position by utilizing the modulation of the polarization state of the light used in the first embodiment, and the second embodiment. It is also possible to combine the method of controlling the emission position using the modulation of the reflection (refraction) state of the light used in (3) with each of the x direction and the y direction.

For example, the control of the emission position using the modulation of the reflection (refraction) state of light is used for the control of the emission position in the y direction,
When the control of the emission position using the modulation of the polarization state of light is used for the control of the emission position in the x direction, the polarization conversion element may change the path of the light from the light source 601a to the light guide unit 603 in the case of FIG. 6, for example. It will be arranged at any position.

Even in this case, the effects of the above-described first and second embodiments of the optical device according to the present invention can be obtained.

(Third Embodiment of Optical Device) Next, a third embodiment of the optical device according to the present invention will be described with reference to FIG. FIG. 13 is an overall schematic view of a third embodiment of the optical device according to the present invention.

In this embodiment, the light source 201a and the polarization conversion element 2 are added to the optical device having the structure of the first embodiment.
01b, the light guide section 201c and the modulation section 201d, a plurality of light emitting elements 1301-1, 1301-2 ,.
, 1301-n are provided, and a plurality of light emitting elements are arranged in a direction parallel to the light incident surface of the light guide section 1303.

Although the number of light emitting elements is 10 in the example shown in FIG. 13, the number of light emitting elements is not limited to 10 in the present embodiment, and the object mounting portion in the y direction is not limited. The number of light emitting elements is determined according to the number of divided cells of 1304.

Next, the configuration of this embodiment will be described. In the present embodiment, as shown in FIG. 13, a plurality of light emitting elements 1301-1, 1301-2, ..., 1301-
n, and a polarization conversion element 1301b for converting the polarization state of light emitted from these light emitting elements. The polarization conversion element 1301b has the same function as that of the polarization conversion element 201b in the first embodiment described above.

In addition, the optical device of this embodiment has the modulator 1
302, a light guide section 1303, and a measured object placing section 1304
And a light guide portion 1305 and a photodetector 1306.

Here, the modulation section 1302 and the light guide section 130.
3, the structure and operation of the measured object placement unit 1304, the light guide unit 1305, and the photodetector 1306 are the same as those of the modulation unit 202, the light guide unit 203, and the measured object mount described in the first embodiment. Table 204, light guide 205, and photodetector 206
Since the structure and the operation are the same, detailed description thereof will be omitted.

In the optical device of this embodiment, the light emitted from each of the light emitting elements 1301-1, 1301-2, ..., 1301-n corresponding to the portion in the y direction of the object mounting portion 1304 is emitted. It is incident on the polarization conversion element 1301b.

The polarization conversion element 1301b converts the incident light into either S-wave or P-wave polarization, and guides the light.
Emit to 3.

The light guide section 1303 is provided with the angle imparting section 1303-1 as in the first embodiment. Then, the function of the angle imparting unit 1303-1 is
The angle imparting unit 20 described in the first embodiment.
Since the same function as that of 3-1 is performed, detailed description thereof will be omitted.

The modulating section 1302 and the light guiding section 1303 allow the light to be measured from a predetermined position in the x-direction and the y-direction among the incident light by the operation described in the first embodiment. It is emitted to 1304.

The object to be measured on the object mounting portion 1304 is
The signal light is emitted by being irradiated with the light emitted from the light guide section 1303.

This signal light enters the light guide portion 1305,
The light is guided inside the light guide portion 1305 and is incident on the photodetector 1306.

In the present embodiment, the light emitting element 13
Each of 01-1, 1301-2, ..., 1301-n may emit light simultaneously, may emit light separately, or may emit light sequentially according to some rule.

As described above, according to this embodiment, the same effect as that of the first embodiment can be obtained, and the light guide section and the modulation section in the y direction are unnecessary, which reduces the cost. It is possible to reduce loss and noise due to light guiding and modulation.

(Fourth Embodiment of Optical Device) Next, a fourth embodiment of the optical device according to the present invention will be described with reference to FIG. FIG. 14 is an overall schematic view of a fourth embodiment of the optical device according to the present invention.

In this embodiment, the light source 601a and the light guide portion 601c are included in the optical device having the structure of the second embodiment.
And a plurality of light emitting elements 140 instead of the modulator 601b.
, 1401-n, and plural light emitting elements are arranged in a direction parallel to the light incident surface of the light guide section 1403.

The number of light emitting elements is 10 in the example shown in FIG. 14, but the number of light emitting elements is not limited to 10 in the present embodiment, and the object mount portion in the y direction is not limited. The number of light emitting elements is determined according to the number of divided cells of 1404.

Next, the configuration of this embodiment will be described. In the present embodiment, as shown in FIG. 14, a plurality of light emitting elements 1401-1, 1401-2, ..., 1401-
n.

Further, the optical device of this embodiment has the modulator 1
402, a light guide section 1403, and an object mounting section 1404.
And a light guide unit 1405 and a photodetector 1406.

Here, the modulation section 1402 and the light guide section 140
3. The structure and operation of the measurement object placement unit 1404, the light guide unit 1405, and the photodetector 1406 are the modulation unit 602, the light guide unit 603, and the measurement object placement unit described in the second embodiment, respectively. Table 604, light guide 605, and photodetector 606
Since the structure and the operation are the same, detailed description thereof will be omitted.

In the optical device of this embodiment, the light emitted from each of the light emitting elements 1401-1, 1401-2, ..., 1401-n corresponding to the y-direction portion of the object mounting portion 1404 is emitted. Angle imparting section 1403 of light guide section 1403
Incident on -1.

The light guide section 1403 is provided with the angle imparting section 1403-1 as in the second embodiment.
The function of the angle imparting unit 1403-1 is the same as that of the angle imparting unit 603-1 described in the second embodiment.
Since the same function as is performed, the detailed description thereof will be omitted.

The modulating section 1402 and the light guiding section 1403 allow the light to be measured from a predetermined position in the x and y directions among the incident light by the operation described in the second embodiment. It is emitted to 1404.

The object to be measured on the object placing portion 1404 is
The signal light is emitted by being irradiated with the light emitted from the light guide 1403.

This signal light enters the light guide portion 1405,
The light is guided inside the light guide portion 1405 and is incident on the photodetector 1406.

In the present embodiment, the light emitting element 14
Each of 01-1, 1401-2, ..., 1401-n may emit light at the same time, may emit light separately, or may emit light sequentially according to some rule.

As described above, according to this embodiment, the same effect as that of the second embodiment can be obtained, and the light guide section and the modulation section in the y direction are not required, and the cost is reduced. Therefore, it is possible to reduce the loss and noise in light guiding and modulation.

(Fifth Embodiment of Optical Device) Next, a fifth embodiment of the optical device according to the present invention will be described with reference to FIG. FIG. 15 is an overall schematic view of a fifth embodiment of the optical device according to the present invention.

In this embodiment, in place of the light guide portion 1405 shown in FIG. 14 in the above-described fourth embodiment, C is used.
This is an embodiment in which a CD (charge-coupled device) 1505 is used as a light receiving unit.

That is, the configuration of this embodiment is the same as that of the above-described fourth embodiment except that a CCD 1505 is used as a light receiving section instead of the light guide section 1405 shown in FIG.

In the present embodiment, the modulator 1402 and the light guide 1403 are composed of the light emitting elements 1401-1, 1401-2,
.., 1401-n are individually selected at predetermined positions in the x direction and emitted to the measured object placement unit 1404.

In this case, the light emitting elements 1401-1 and 140
All of 1-2, ..., 1401-n may emit light at the same time, or one or a plurality of light emitting elements may emit light at the same time.

For example, when a plurality of objects to be measured on the object mounting portion 1404 are simultaneously irradiated with light, signal light is emitted from each of the objects to be measured at the same time. To be measured.

The CCD 1505 is the object mounting unit 140.
It is possible to measure the incident light by providing an independent light measuring section corresponding to each one of the objects to be measured on the one-to-one basis.

Thus, the fifth optical device according to the present invention is
According to this embodiment, the same effects as those of the above-described optical device according to the fourth embodiment of the present invention can be obtained, and
At the same time, the signal light can be read from a plurality of measured objects, and the measurement time can be shortened.

Here, in the above fifth embodiment, the case where the CCD is used for the light receiving portion in the structure of the fourth embodiment has been taken as an example, but in the above-described third embodiment shown in FIG. In the structure, the light guide portion 1305 and the photodetector 1306
Instead of this, a CCD may be used.

Even in this case, it is possible to obtain the same effect as that of the above-described third embodiment and shorten the measurement time.

Further, in the structure of the first embodiment shown in FIG. 2, a CCD is used instead of the light guide section 205 and the photodetector 206, or the second embodiment shown in FIG. 6 is used. In the structure of the embodiment, a CCD may be used instead of the light guide portion 605 and the photodetector 606.

(Sixth Embodiment of Optical Device) Next, a sixth embodiment of the optical device according to the present invention will be described with reference to FIG. 16A is a partial sectional view of a conventional optical device, and FIG. 16B is a partial sectional view of a sixth embodiment of the optical device according to the present invention.

The present embodiment is an embodiment in which the microlens array is arranged on at least one of the upper and lower sides of the object mounting portion in the above-described first to fifth embodiments. . The structure of this embodiment is the same as that of any of the first to fifth embodiments described above except that a microlens array is arranged. Therefore, detailed description of the same portions is omitted.

This embodiment is an embodiment for improving the detection accuracy of the optical device.

That is, as shown in FIG. 16 (a), in the case of no microlens array, the object 160 to be measured is
The reference light 1605 radiated to No. 2 has a large spread, and light may hit the portion other than the target cell, resulting in loss of the reference light 1606, which may reduce efficiency and cause noise. .

Since the signal light 1606 emitted from the device under test 1602 also has various directional components,
A part of it goes out of the light guide section, and the loss of signal light 16
It becomes 07, which causes a decrease in efficiency.

Therefore, in the present embodiment, (b) of FIG.
As shown in FIG. 7, a microlens array 1608 is provided below the object-to-be-measured mounting portion 1601, and a microlens array 1609 is provided above the object-to-be-measured mounting portion 1601.
Was set up.

Therefore, in the present embodiment, as shown in FIG. 16B, the light incident on the object 1602 to be measured is subjected to the condensing action by the microlens array 1608, and the object 1602 to be measured of the target cell is. The intensity of the light radiated on the object increases.

Further, the light emitted from the object 1602 to be measured also passes through the microlens array 1609, so that the scattered component is reduced and the intensity of the signal light guided to the photodetection section is increased.

Therefore, in this embodiment, the same effect as that of any one of the first to fifth embodiments of the optical device according to the present invention described above can be obtained, and the measured object 1602 is irradiated. As the light intensity of the light increases, the intensity of the signal light emitted from the measured object also increases and the detection sensitivity improves.

Further, in the present embodiment, it is possible to suppress irradiation to unnecessary portions, so that noise can be reduced and detection sensitivity is improved.

Furthermore, in the present embodiment, the device under test 160
The signal light emitted from the microlens array 160
As a result, the signal light intensity at the photodetector is increased and the detection sensitivity is improved.

In this embodiment, as shown in FIG. 16B, the microlens arrays are provided both above and below the object-to-be-measured mounting portion 1601, but the object-to-be-measured mounting portion 1601 is provided. The microlens array may be provided on either the upper side or the lower side.

(Seventh Embodiment of Optical Device) Next, a seventh embodiment of the optical device according to the present invention will be described with reference to FIG. FIG. 17 is a partial cross-sectional view of a seventh embodiment of the optical device according to the present invention, and FIG.
17B is a partial sectional view of a first example of the seventh embodiment of the optical device according to the present invention. FIG. 17B is a partial sectional view of the second example of the seventh embodiment of the optical device according to the present invention. It is a figure.

In this embodiment, in any one of the first to sixth embodiments described above, the lens portion is formed under the measured object placing portion or inside the measured object placing portion. It is an embodiment.

This embodiment is one of the first to sixth embodiments described above except that the lens portion is formed in the lower portion of the measured object placing portion or inside the measured object placing portion. Since the heels have the same structure, detailed description of the similar parts will be omitted.

This embodiment is, like the sixth embodiment, an embodiment for improving the detection accuracy of the optical device.

That is, in the sixth embodiment described above, the microlens array is used to improve the light intensity, but in the present embodiment, in order to improve the light intensity,
A lens portion was provided on the object mounting portion.

That is, for example, as shown in FIG. 17A, the object 17 to be measured is placed on the object mounting portion 1701.
02 is placed.

In this embodiment, each of the objects to be measured is placed on the lower part of the object to be measured placing portion 1701, that is, on the surface side where the reference light for irradiating the object to be measured 1702 is incident. A lens portion 1703 corresponding to the portion is formed.

Therefore, in the present embodiment, the device under test 17
The intensity of the reference light with which the light beam 02 is irradiated can be improved.

As shown in FIG. 17B,
As the structure of the object mounting portion 1701, the lens portion 170
3 may be divided into a portion having 3 and a portion 1704 covering this portion, and each portion may be formed as a portion having a different refractive index.

The embodiment shown in FIG. 17B is different from the embodiment shown in FIG.
It has the same structure as that covered with a material having a different refractive index from the portion having.

At least one of these portions having different refractive indexes may be made of resin. Even with the configuration shown in FIG. 17B, the same effect as that of the measured object placement portion 1701 shown in FIG. 17A can be obtained.

Therefore, in the present embodiment, the device under test 1
The light incident on 702 is condensed by the lens portion 1703, and the intensity of the light radiated to the measured object 1702 of the target cell increases.

Therefore, in this embodiment, the same effect as that of any one of the first to sixth embodiments of the optical device according to the present invention described above can be obtained, and the measured object 1702 is irradiated. The increase in the light intensity of the signal increases the intensity of the signal light emitted from the measured object and further improves the detection sensitivity.

Further, in the present embodiment, it is possible to suppress irradiation to unnecessary portions, so that noise can be reduced and detection sensitivity is improved.

(Structure of Lens Section) Here, the structure of the lens section used in the above-described sixth and seventh embodiments will be described with reference to FIG. FIG.
[Fig. 6] is a partially enlarged view of the structure of a lens unit used in the sixth embodiment and the seventh embodiment.

The lens portion used in the embodiment of the optical device according to the present invention has not only the lens shape as shown in FIG. 18A, but also the prism shape as shown in FIG. 18B. It may be.

Moreover, the lens portion used in the embodiment of the optical device according to the present invention may be convex or concave. Further, the refractive index of the lens portion can be appropriately selected depending on the material of the substrate and the like.

(Eighth Embodiment of Optical Device) Next, an eighth embodiment of the optical device according to the present invention will be described with reference to FIG. FIG. 19 is an overall schematic view of an eighth embodiment of the optical device according to the present invention.

This embodiment is the same as any one of the first to seventh embodiments of the optical device according to the present invention described above, but with a function for positioning the measurement position of the object to be measured. Is.

That is, in the present embodiment, the incident section 190
1, the light guide section 1903 and the modulation section 190 to which light is incident
2 and at least one of the measurement object mounting portions 1904,
An alignment mark 1905 is formed for positioning the measured object placement portion 1904 in the x and y directions.

Here, in the present embodiment, the incident section 190 is used.
1 is a light source 201 in the first embodiment shown in FIG.
a, polarization conversion element 201b, light guide section 201c, modulation section 2
It corresponds to 01d.

The modulating unit 1902 corresponds to the modulating unit 102 shown in FIG. 1, the light guiding unit 1903 corresponds to the light guiding unit 103 shown in FIG. 1, and the measured object placing unit 1904 is shown in FIG.
Corresponds to the measured object placement unit 104 shown in FIG.

Further, in the present embodiment, the light guide section 1903.
Between the object-to-be-measured object mounting portion 1904 and the object-to-be-measured object mounting part 1
A spacer 1906 for positioning the 904 in the z direction is provided.

In the present embodiment, the object mounting portion 1904 may have a replaceable structure. For example, the DNA chip or the like as the object mounting part is basically disposable at present.

In this embodiment, since it is necessary to install the object to be measured in the analyzer using the optical device according to the present invention before the measurement, the alignment marks are formed in the light guide section and the modulation section. A mark corresponding to the mark is formed in advance on the object to be measured so that the mark can be used for installation alignment in the x and y directions during installation.

In the present embodiment, the alignment mark may be used to perform alignment by image processing, or the mark itself may be formed into a corresponding uneven pattern for physical alignment. good.

Furthermore, by disposing a spacer 1906 for positioning the measured object placing section 1904 in the z direction between the light guide section 1903 and the measured object placing section 1904,
The height can be controlled to an arbitrary distance also in the z direction.

In the present embodiment, the positioning in the x and y directions using the alignment marks and the positioning in the z direction using the spacers are both performed at the same time. , Y direction or z direction using a spacer may be performed.

As described above, according to this embodiment, it is possible to obtain the effect of any one of the first to seventh embodiments of the optical device according to the present invention described above, and to measure the object to be measured. In order to ensure the accuracy of analysis, it is necessary to accurately irradiate the cell of the target measured object with light, but by providing the alignment mark 1905 and the spacer 1906, there is a positional shift when the measured object is installed. Noise and loss can be reduced and analysis accuracy can be improved.

(Ninth Embodiment of Optical Device) Next, a ninth embodiment of the optical device according to the present invention will be described with reference to FIG. FIG. 20 is a schematic configuration diagram of the ninth embodiment of the optical device according to the present invention.

In addition to the structure of any one of the first to seventh embodiments of the optical device according to the present invention described above, this embodiment is the same as the optical device of the structure shown in FIG.
Modulation section 102, light guide section 103, and measured object placement section 104
Are integrally fixed to each other in position.

That is, in the ninth embodiment of the optical device according to the present invention, the resin 2010 is inserted between the modulation section 2002 and the light guide section 2003, and further, the light guide section 2003 and the object mount section. Resin 2011 is inserted between 2004 and 2004.

Here, the modulation unit 2002 corresponds to the modulation unit 102 shown in FIG. 1, the light guide unit 2003 corresponds to the light guide unit 103 shown in FIG.
Corresponds to the measured object placement unit 104 shown in FIG.

In this embodiment, the resin 2010 is inserted between the modulation section 2002 and the light guide section 2003,
No. 03 and the object to be measured 2004 are inserted into the resin 2011, the modulator 2002 and the light guide 2003
Also, the measured object placement portion 2004 is positionally fixed and integrated with each other.

Here, the resin 2010 and the resin 2011
It is preferable to release the fixation between the upper and lower parts by applying energy such as heat.

As described above, in this embodiment, it is possible to obtain the effect of any one of the first to seventh embodiments of the above-described optical device according to the present invention, and in addition to the modulation unit 2002 in advance. Light guide section 2003, light guide section 2003
By integrating the measurement target placement unit 2004 and the object-to-be-measured portion 2004 and fixing them in position relative to each other, alignment at the time of analysis becomes unnecessary, cost reduction due to simplification of the device, improvement of analysis accuracy,
Higher speed is possible.

In addition, the modulation section 2002 and the light guide section 2003,
Integration of the light guide unit 2003 and the object placement unit 2004,
By making it possible to separate the positional fixations from each other, it is possible to dispose only the measured object placing portion 2004, and the modulating portion 2002 and the light guide portion 2003 can be easily recycled. . Cost reduction,
The effect of reducing waste is obtained.

However, in the present embodiment, the modulator 20
02 and the light guide portion 2003, and between the light guide portion 2003 and the measured object placement portion 2004 and fixing the upper and lower parts thereof are not limited to the resin.

That is, in this embodiment, the modulator 2
002 and the light guide part 2003, and between the light guide part 2003 and the to-be-measured object mounting part 2004, and what fixes the upper and lower parts of each are fixing the upper and lower parts. If it is suitable, further cost reduction,
In order to obtain the effect of reducing the amount of waste, it suffices that it is easy to release the fixation between the upper and lower parts by thermal energy or the like.

(Example of Measured Object Placement Part and Measured Object) Here, an example of the measured object mount and the measured object used in each embodiment of the optical apparatus according to the present invention will be described.

Various objects can be considered as the object mounting part and the object to be measured. As a first example, a DNA chip can be mentioned.

A DNA chip is for immobilizing a large number of different DNA probes on a glass substrate at a high density, hybridizing the DNA probes, detecting signals such as fluorescence, and performing a large-scale analysis by a computer. is there.

Therefore, in the DNA chip, the glass substrate constitutes the subject mounting portion, and the DNA probe constitutes the subject.

Further, the second part of the object mounting portion and the second object of the object is measured.
As an example, a DNA microarray can be mentioned.

A DNA microarray has the same structure and function as a DNA chip, but the manufacturing method uses a semiconductor process for a DNA chip, whereas a DNA microarray is a spotter that is manufactured by dropping a probe. To do. DNA probes are arranged at a higher density on the DNA chip.

Therefore, in the DNA microarray, the glass substrate constitutes the subject mounting portion and the DNA probe constitutes the subject.

[0270] Further, the measured object placing portion and the third object of the measured object
An example is an ECA chip.

The ECA chip has the same structure and function as the DNA chip, but uses electricity for detection. In some cases, both electricity and light are used.

Therefore, in the ECA chip, the glass substrate constitutes the subject mounting portion and the DNA probe constitutes the subject.

Also, the measured object placing portion and the fourth object of the measured object
A protein chip can be mentioned as an example.

The protein chip is used for analyzing a gene, whereas the DNA chip is used for analyzing a gene.

Therefore, in the ECA chip, the glass substrate constitutes the subject mounting portion and the DNA probe constitutes the subject.

However, the measurement object placing portion and the measurement object used in the embodiment of the optical device according to the present invention are not limited to the above examples, and various other things can be used.

(Embodiment of Analysis System) Next, an analysis system according to the present invention will be described with reference to FIGS. 21, 22 and 23.
Will be described with reference to. 21 is an overall configuration diagram of an embodiment of the analysis system according to the present invention, FIG. 22 is an internal block diagram of the analysis apparatus shown in FIG. 21, and FIG. 23 is an embodiment of the analysis system shown in FIG. 3 is a flowchart of the operation of FIG.

As shown in FIG. 21, the analysis system according to the present invention comprises an optical device 2101 and an analysis device 2102.
And an information database 2103.

As the optical device 2101, any one of the above-described first to ninth embodiments of the optical device according to the present invention is used.

The analysis device 2102 is a device for making comparison and determination based on the information input from the optical device 2101 and the information database 2103.

The information database 2103 is used by the analyzer 2.
Reference data necessary for analysis by 102 is stored. The information database 2103 is composed of a server having, for example, a hard disk.
As will be described later, this information database 2103 can be changed to a recording medium storing information such as a card or used together with such a card.

Optical device 2101 and analysis device 2102
And the information database 2103 may be connected to each other via a network, each device may be housed in one device (housing), or the analysis device 210.
Optical device 2101 and information database 210 inside
One of 3 may be stored.

Next, the analyzer 2102 shown in FIG.
The internal configuration of will be described with reference to FIG.

The analyzer 2102 shown in FIG. 21 includes a control unit 2201, a transmission / reception unit 2202, and a comparison / determination unit 22.
03 and a storage unit 2204, each of which is a bus 22.
It is connected by 05.

The control unit 2201 controls the operation of each unit. The transmission / reception unit 2202 exchanges information with the outside. The comparison / determination unit 2203 performs comparison and determination based on the input information.

The storage unit 2204 stores a program necessary for processing, and stores a comparison / determination result and input information.

The functions of the respective units shown in FIG. 22 are realized by the CPU provided in the analyzer alone or in cooperation with other members or with a program stored in the main memory or the auxiliary memory. .

Also, the storage unit 2204 stores, for example, RA
It is composed of an M, a ROM, a hard disk, and the like.

Next, the operation of the analysis system shown in FIG. 21 will be described with reference to FIG.

First, the optical device 2101 performs measurement (step 2301), and this measurement information is transmitted to the analysis device 2102.

The measuring operation of the optical device in step 2301 is the same as the measuring operation in the first to ninth embodiments of the optical device according to the present invention described above.

Analyzing device 2102 to which the measurement information is transmitted
Receives comparison information from the information database 2103,
The measurement information and the comparison information are compared (step 230).
2).

Then, the analyzer 2102 makes a determination based on the comparison result (step 2303). This decision is
For example, as a result of comparison, the measurement information and the comparison information may or may not match.

Next, the analyzer 2102 outputs the judgment result (step 2304) and ends the operation.

As described above, in the embodiment of the analysis system according to the present invention, it is possible to output the determination result based on the result measured by the optical device 2101 by the analysis of the analysis device 2102.

Here, in the above embodiment, the analyzer 21 is used.
Although the comparison information stored in the information database 2103 is used as the information used by 02, the comparison information stored in a recording medium such as a card may be used as the information used by the analysis device 2102.

In this case, the information inside the recording medium such as a card may be read by a reading device such as a card reader connected to the analyzer and transmitted to the analyzer.

(Personal collation method using analysis system) Next, a case where one embodiment of the analysis system according to the present invention is applied to the principal collation method will be described with reference to FIG. This personal identification method is an embodiment of the personal identification method according to the present invention. FIG. 24 is a flowchart of an embodiment of the personal identification method according to the present invention.

An embodiment of the personal identification method according to the present invention is a method for personal identification using the embodiment of the analysis system according to the present invention described above.

By using an embodiment of the person verification method according to the present invention, for example, a security system is constructed by judging whether or not to allow a room to enter a room based on the verification result, Prevent unauthorized use of credit cards and other cards.

In the personal identification method of this embodiment, the analyzing apparatus 2102 shown in FIG. 21 uses the information obtained from the optical apparatus 2101 (step 2401) and known information such as information stored in a database or a card (step 24
02) to determine the identity of the person (step 2403).

These steps 2401 to 24
The operation up to 03 corresponds to the operation from step 2301 to step 2303 of the flowchart shown in FIG.

After the analyzer determines the identity, the analyzer permits the entry or the use of the card based on the determination result (step 2404), or the entry is not permitted or the card is not used. Is not permitted (Step 2
405).

Therefore, when an embodiment of the personal identification method according to the present invention is applied to a security system using genetic information, the following operation is performed.

(1) The analysis system of the above embodiment is installed at the entrance of a room or the like, and the embodiment of the analysis system according to the present invention reads the genetic information of the person who is about to enter the room.

(2) Gene information of a person who is allowed to enter the room is stored in advance as a database in the system, and one embodiment of the analysis system according to the present invention is to determine whether the person who wants to enter the room is permitted. A comparison judgment is made based on the information stored in this database.

(3) In one embodiment of the analysis system according to the present invention, the door is unlocked by a person who is permitted to enter the room, and is not unlocked by a person who is not permitted to enter the room.

When an embodiment of the personal identification method according to the present invention is applied to a card use permission method using genetic information, the following operation is performed.

(1) Record genetic information of a regular user in a credit card or the like.

(2) One embodiment of the analysis system according to the present invention analyzes a user's genetic information when using a credit card.

(3) In one embodiment of the analysis system according to the present invention, the stored information on the card is compared with the analysis result to determine whether the user is an authorized user.

(4) One embodiment of the analysis system according to the present invention permits the use of the card when the user is a regular user, and does not allow the use of the card when the user is not a regular user.

By the embodiment of the personal identification method according to the present invention as described above, the personal identification method with higher accuracy can be obtained as compared with the fingerprint identification, face recognition and the like.

(Allergy / side effect test method) Next, an allergy / side effect test method using an embodiment of the analysis system according to the present invention will be described with reference to FIG. An allergy / side effect inspection method using this embodiment of the analysis system according to the present invention is an embodiment of the allergy / side effect inspection method according to the present invention. Therefore, FIG. 25 is a flowchart of one embodiment of the allergy / side effect inspection method according to the present invention.

In the allergy / side effect test method of this embodiment, the analyzer shown in FIG. 21 uses the information obtained from the optical device (step 2501) and the group information stored in the database for generating allergies / side effects. The attribute of the gene of the user is determined based on (step 2502) (step 2503).

These steps 2501 to 25
The operation up to 03 corresponds to the operation from step 2301 to step 2303 of the flowchart shown in FIG.

After the attribute is judged by the analyzer, the analyzer gives an instruction to stop the use of food or medicine based on the judgment result (step 2504) or permits the use of food or medicine. (Step 2505).

As described above, in the allergy / side effect test method of this embodiment using one embodiment of the analysis system of the present invention, for example, in the case of making a judgment using genetic information,
The operation is as follows.

(1) The gene information of the group that causes allergies and side effects when providing the disclosed foods and medicines is stored in the database.

(2) One embodiment of the analysis system according to the present invention analyzes the genetic information of the user before the user uses the food or medicine.

(3) One embodiment of the analysis system according to the present invention determines whether or not the gene of the user belongs to the provided group information. In this determination, it is determined whether allergies or side effects do not occur even if the food or drug is used.

(4) One embodiment of the analysis system according to the present invention permits the use of foods and medicines when they do not belong to the group, and if they do belong, allergies and the like may occur, so do not use them. Give instructions.

Therefore, in the allergy / side effect inspection method according to the present embodiment, it was often impossible to know allergies or side effects until ingestion, but by using this system, the judgment can be made in advance.
The danger can be avoided.

[0324]

As described above, the present invention controls the emission position of light by modulating the polarization state or reflection (refraction) state of light to measure the object to be measured.
It is possible to reduce the size, increase the speed, and reduce the cost.

[Brief description of drawings]

FIG. 1 is a schematic diagram for explaining an outline of an embodiment of an optical device according to the present invention.

FIG. 2 is an overall schematic diagram of a first embodiment of an optical device according to the present invention.

FIG. 3 is an enlarged cross-sectional view of a portion A shown in FIG.

4 is an enlarged cross-sectional view of a portion B shown in FIG.

5 is a schematic diagram of the relationship between the emission position of the light selected by the modulator and the position of the measured object on the measured object mounting section in the optical device shown in FIG.

FIG. 6 is an overall schematic diagram of a second embodiment of an optical device according to the present invention.

7 is an enlarged cross-sectional view of a portion C shown in FIG.

FIG. 8 is a schematic view of a birefringence structure of liquid crystal molecules used in a liquid crystal layer of a second embodiment of an optical device according to the present invention.

9 is an enlarged cross-sectional view of a portion D shown in FIG.

FIG. 10 is a process drawing of the method of manufacturing the uneven shape of the reflection plate including the reflection film used in the second embodiment of the optical device according to the present invention by the 2P method.

FIG. 11 is a process drawing of the manufacturing method of the uneven shape of the reflection plate including the reflection film used in the second embodiment of the optical device according to the present invention by the 2P method.

FIG. 12 is a process drawing of a method for manufacturing an uneven shape of a reflection plate including a reflection film used in the second embodiment of the optical device according to the present invention by an embossing method.

FIG. 13 is an overall schematic diagram of a third embodiment of an optical device according to the present invention.

FIG. 14 is an overall schematic view of a fourth embodiment of the optical device according to the present invention.

FIG. 15 is an overall schematic view of a fifth embodiment of an optical device according to the present invention.

16A is a partial cross-sectional view of a conventional optical device, and FIG. 16B is a partial cross-sectional view of a sixth embodiment of the optical device according to the present invention.

FIG. 17 is a partial cross-sectional view of a seventh embodiment of the optical device according to the present invention.

FIG. 18 is a partially enlarged view of the structure of a lens unit used in the sixth embodiment and the seventh embodiment.

FIG. 19 is an overall schematic view of an eighth embodiment of an optical device according to the present invention.

FIG. 20 is a schematic configuration diagram of a ninth embodiment of an optical device according to the present invention.

FIG. 21 is an overall configuration diagram of an embodiment of an analysis system according to the present invention.

22 is an internal block diagram of the analyzer shown in FIG. 21. FIG.

FIG. 23 is a flowchart of the operation of the embodiment of the analysis system shown in FIG. 21.

FIG. 24 is a flowchart of an embodiment of the personal identification method according to the present invention.

FIG. 25 is a flowchart of one embodiment of the allergy / side effect test method according to the present invention.

[Explanation of symbols]

101 incident part 102 modulation part 103 light guide part 104 to-be-measured body mounting part 105 light receiving part 201a light source (light source means) 201b polarization conversion element (polarization conversion means) 201c light guide part (first light guide means) 201c-1 Angle imparting unit 201d Modulating unit (first modulating unit) 202 Modulating unit (second modulating unit) 203 Light guiding unit (second light guiding unit) 203-1 Angle imparting unit 204 Measured object placement unit (measured object) Measuring object mounting means) 205 Light guide part (light receiving means, third light guiding means) 206 Photodetector (light receiving means, light detecting means) 301 Reflecting plate (first reflecting means) 302 Liquid crystal layer (first Liquid crystal layer) 303 Light guide portion 304 Bragg grating pattern (first transmission / reflection control means) 305 Liquid crystal cell 401 Reflector plate (second reflection means) 402 Liquid crystal layer (second liquid crystal layer) 403 Light guide portion 404 Black Grating pattern (second transmission / reflection control means) 405 Liquid crystal cell 406 Measured object placement part 407 Measured object 501 Modulation part 501a Liquid crystal cell 502 Modulation part 502a Liquid crystal cell 503 Measured cell 504 Measured object 505 Measured object mount Mounting plate part 601a Light source (light source means) 601b Modulation part (first modulation means) 601c Light guide part (first light guide means) 601c-1 Angle imparting part 602 Modulation part (second modulation means) 603 Light guide Part (second light guide means) 603-1 Angle imparting part 604 Measured object placing part (measured object placing means) 605 Light guiding part (light receiving means, third light guiding means) 606 Photodetector ( (Light receiving means, light detecting means) 701 reflection film (first reflection means) 702 liquid crystal layer (first liquid crystal layer) 703 light guide 705 liquid crystal cell 901 reflection film (second reflection means) 902 liquid crystal layer ( Second liquid crystal layer) 903 Light guide part 904 Measured object mounting part 905 Liquid crystal cell 906 Measured object 1001 Substrate 1002 Resist 1003 Master 1004 Stamper 1004a Inversion pattern 1005 UV curable resin 1005a Pattern 1006 Reflective film 1008 Reflective plate 1009 Resin 1009a Patterns 1301-1, 1301-2, 1301-n Light emitting element (light source means) 1301b Polarization conversion element (polarization conversion means) 1302 Modulation section (second modulation means) 1303 Light guide section (second light guide means) 1303 -1 Angle imparting section 1304 Measured object placing section (measured object placing means) 1305 Light guide section (light receiving means, third light guiding means) 1306 Photodetector (light receiving means, light detecting means) 1401-1 , 1401-2, 1401-n light emitting element (light source means) 1402 modulator (second modulation) Means) 1403 Light guide unit (second light guide unit) 1403-1 Angle imparting unit 1404 Measured object placement unit (measured object placement unit) 1405 Light guide unit (light receiving unit, third light guide unit) 1406 Photodetector (light receiving means, photodetecting means) 1505 CCD 1601 Object to be measured placing section 1602 Object to be measured 1605 Reference light 1606 Reference light loss 1606 Signal light 1607 Loss of signal light 1608 Microlens array (first collection Light means) 1609 Microlens array (second light collecting means) 1701 Measured object placing part 1702 Measured object 1703 Lens part (third light collecting means) 1704 Covering part (cover part) 1901 Incident part 1902 Modulating part 1903 Light guide part 1904 Measured object mounting part 1905 Alignment mark (first positioning means) 1906 Spacer (second positioning hand) ) 2002 modulation unit 2003 light guide unit 2004 measured object placement unit 2010, 2011 resin (fixing unit) 2101 optical device 2102 analysis device 2103 information database (storage unit) 2201 control unit 2202 transmission / reception unit 2203 comparison determination unit 2204 storage unit 2205 bus

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) // G01N 33/483 G01N 33/53 M 4C038 33/53 37/00 102 37/00 102 A61B 5/10 320Z (72) Tomohiko Matsushita Tomohiko Matsushita, No. 801, Fudogawa-cho, Horikawa Higashiiriminami Fudodo-cho, Shiojiji-dori, Shimogyo-ku, Kyoto Omron Co., Ltd. F-term (reference) 2G043 AA03 BA16 DA06 EA01 FA01 GA06 GA07 GB01 GB18 GB21 HA01 HA05 HA07 JA04 KA09 LA01 LA03 2G045 AA35 DA13 FA11 FB02 GC15 JA07 2G059 AA05 AA06 BB12 DD13 EE01 EE02 EE07 GG01 GG02 GG03 GG04 GG06 JJ05 JJ11 JJ12 JJ13 JJ18 JJ18 QC01 QC01 QC01 KK04 QC05 BBQ29 QAQQA QAQQA QAQA

Claims (31)

[Claims] 1. A light source unit that emits light, a polarization conversion unit that converts the polarization state of the light from the light source unit, and a first light guide unit that guides the light emitted from the polarization conversion unit in a first direction. A light guide means, a first modulator means for modulating a polarization state of light guided through the first light guide means at a predetermined position in the first direction, and the first light guide means A first transmission / reflection control unit formed on the surface of the control unit for controlling transmission and reflection of light according to a polarization state of the light; and guiding light transmitted through the first reflection / transmission control unit in a second direction. Second light guide means for emitting light; second modulator means for modulating the polarization state of the light guided through the second light guide means at a predetermined position in the second direction; A second light guide formed on the surface of the second light guide means for controlling transmission and reflection of light according to the polarization state of light. Hyper-reflection control means, measurement object mounting means for mounting a measurement object irradiated with light transmitted through the second reflection / transmission control means, and light reception for receiving light emitted from the measurement object An optical device comprising: 2. The first modulation means comprises a plurality of liquid crystal cells arranged in the first direction.
And a first reflection means formed on the surface of the first liquid crystal layer, the surface being opposite to the surface on which the first light guide means is formed. 2. The optical device according to claim 1, wherein the polarization state of the light is modulated at a predetermined position in the first direction by applying a voltage to the liquid crystal cell at the predetermined position in the first direction. . 3. The second modulation means comprises a plurality of liquid crystal cells arranged in the second direction.
Liquid crystal layer and a second reflecting means formed on the surface of the second liquid crystal layer opposite to the surface on which the second light guide means is formed. 3. The polarization state of the light is modulated at a predetermined position in the second direction by applying a voltage to the liquid crystal cell at the predetermined position in the second direction. Optical device. 4. A liquid crystal of a first liquid crystal layer which constitutes the first modulating means, or a second liquid crystal which constitutes the second modulating means.
At least one of the liquid crystals of the liquid crystal layer is sandwiched between the first alignment film and the second alignment film, and the twist angle between the first alignment film and the second alignment film is 45 °. The optical device according to claim 3. 5. A light source unit that emits light, a first light guide unit that guides the light emitted from the light source unit in a first direction, and a refractive index at a predetermined position in the first direction. First modulation means for allowing the light guided through the first light guide means to enter by being modulated, and the surface of the first modulation means, which is the formation of the first light guide means. And a first light guide means formed on a surface opposite to a side where the light is incident, the first light guide means reflecting the light entering the first modulator to the first light guide means. Second light guiding means for guiding the light emitted from the second direction in the second direction, and guiding the second light guiding means by modulating the refractive index at a predetermined position in the second direction. Second modulating means for allowing incident light to enter, and a surface of the second modulating means, wherein the second light guiding means is formed. A second reflecting means for reflecting the light incident on the second modulating means to the second light guiding means side, the second reflecting means being formed on a surface opposite to the second light guiding means. An optical device comprising: an object-to-be-measured mounting means for mounting an object-to-be-measured on which the emitted light is irradiated; and a light-receiving means for receiving light emitted from the object-to-be-measured. 6. The first modulation means comprises a plurality of liquid crystal cells arranged in the first direction.
The liquid crystal layer is provided, and the refractive index of the liquid crystal cell is modulated at a predetermined position in the first direction by applying a voltage to the liquid crystal cell at the predetermined position in the first direction. Item 5. The optical device according to item 5. 7. The second modulation means comprises a plurality of liquid crystal cells arranged in the second direction.
The liquid crystal layer is provided, and the refractive index of the liquid crystal cell is modulated at a predetermined position in the second direction by applying a voltage to the liquid crystal cell at the predetermined position in the second direction. Item 7. The optical device according to Item 5 or 6. 8. A light source unit that emits light, a polarization conversion unit that converts the polarization state of the light from the light source unit, and a first light guide unit that guides the light emitted from the polarization conversion unit in a first direction. A light guide means, a first modulator means for modulating a polarization state of light guided through the first light guide means at a predetermined position in the first direction, and the first light guide means A first transmission / reflection control unit formed on the surface of the control unit for controlling transmission and reflection of light according to a polarization state of the light; and guiding light transmitted through the first reflection / transmission control unit in a second direction. Second light guide means for illuminating light, and second modulator means for making light guided through the second light guide means incident by modulating the refractive index at a predetermined position in the second direction. And a surface of the second modulation means, which is opposite to the side on which the second light guide means is formed. Second reflecting means formed on a surface for reflecting the light incident on the second modulating means to the second light guiding means side, and light emitted from the second light guiding means are irradiated. An optical device comprising: a measured object placing means for placing an measured object; and a light receiving means for receiving light emitted from the measured object. 9. A light source means for emitting light, a first light guide means for guiding the light emitted from the light source means in a first direction, and a refractive index at a predetermined position in the first direction. First modulation means for allowing the light guided through the first light guide means to enter by being modulated, and the surface of the first modulation means, which is the formation of the first light guide means. And a first light guide means formed on a surface opposite to a side where the light is incident, the first light guide means reflecting the light entering the first modulator to the first light guide means. Second light guide means for guiding the light emitted from the light source in the second direction, and polarization of the light arranged at any position of the light path from the light source means to the second light guide means. A polarization conversion means for converting the state, and a polarization state of light guided through the second light guide means at a predetermined position in the second direction. A second modulation means for modulating the light in the second light guide means, a second transmission / reflection control means formed on the surface of the second light guide means for controlling light transmission and reflection according to a polarization state of the light, 2. The object-to-be-measured mounting means for mounting the object-to-be-measured on which the light transmitted through the reflection / transmission control means 2 is irradiated, and the light-receiving means for receiving the light emitted from the object-to-be-measured. Optical device. 10. Light source means arranged in the first direction, the number of which is the same as the number of the measured object mounting portions in the first direction of the measured object mounting means, and polarization of light from the light source means. A polarization conversion means for converting the state, and a second light guide for guiding the light from the polarization conversion means in a second direction.
The second light guiding means, the second light guiding means for modulating the polarization state of the light guided through the second light guiding means at a predetermined position in the second direction, and the second light guiding means. Second transmission / reflection control means formed on the surface of the means for controlling the transmission and reflection of the light according to the polarization state of the light, and the light under measurement irradiated with the light transmitted through the second reflection / transmission control means. An optical device comprising: a measured object placing means for placing a body; and a light receiving means for receiving light emitted from the measured object. 11. The second modulation means comprises a plurality of liquid crystal cells arranged in the second direction.
Liquid crystal layer and a second reflecting means formed on the surface of the second liquid crystal layer opposite to the surface on which the second light guide means is formed. 11. The optical device according to claim 10, wherein the polarization state of the light is modulated at a predetermined position in the second direction by applying a voltage to the liquid crystal cell at the predetermined position in the second direction. . 12. The liquid crystal of the second liquid crystal layer which constitutes the second modulation means is sandwiched between a first alignment film and a second alignment film, and the first alignment film and the second alignment film. The optical device according to claim 11, wherein a twist angle with respect to is 45 °. 13. Light source means arranged in the first direction, the light source means being arranged in the first direction by the same number as the number of parts to be measured placed in the first direction of the means to be measured means, and the light emitted from the light source means. And a second light guide means for guiding the light in a second direction, and a light guided through the second light guide means by modulating a refractive index at a predetermined position in the second direction. The second modulating means for making incident light, and the incident light formed on the surface of the second modulating means opposite to the side on which the second light guiding means is formed, Second reflection means for reflecting the light to the light guide means side of the second object; object-to-be-measured means for mounting the object to be measured irradiated with the light emitted from the second light guide means; and the object to be measured. An optical device comprising: a light receiving unit that receives the light emitted from the optical device. 14. The second modulation means comprises a plurality of liquid crystal cells arranged in the second direction.
The liquid crystal layer is provided, and the refractive index of the liquid crystal cell is modulated at a predetermined position in the second direction by applying a voltage to the liquid crystal cell at the predetermined position in the second direction. Item 14. The optical device according to item 13. 15. The light receiving means comprises: a third light guiding means for guiding the light emitted from the object to be measured; and a light detecting means for detecting the light guided by the third light guiding means. The optical device according to any one of claims 1 to 14, further comprising: 16. The plurality of CCDs (char) capable of independently measuring the light emitted from the plurality of measured objects on the measured object placing means by the light receiving means.
15. The optical device according to claim 1, which is configured by a ge-coupled device. 17. The first condensing means for condensing light to be radiated to the object to be measured on the object to be measured placing means is provided below the object to be measured placing means. The optical device according to any one of claims 1 to 16. 18. A second condensing means for condensing light emitted from the measured object on the measured object mounting means is provided above the measured object mounting means. The optical device according to any one of claims 1 to 17. 19. A third surface for condensing the light radiated to the object to be measured, on a surface of the object to be measured placing means opposite to a surface on which the object to be measured is placed. The optical device according to any one of claims 1 to 18, wherein a condensing unit is formed. 20. A cover part is provided for covering a surface of the measured object mounting means opposite to a surface on which the measured object is mounted, the refractive index of a material of the cover part and the third part. 20. The optical device according to claim 19, wherein the material of the portion where the light collecting means is formed has a different refractive index. 21. Positioning of the measured object placing means in the plane direction of the measured object placing means and at least one of the second light guide means and the second modulating means. The optical device according to any one of claims 1 to 20, wherein the first positioning means is formed. 22. Second positioning means for positioning in the direction perpendicular to the surface of the measured object placing means is formed between the measured object placing means and the second light guide means. The optical device according to any one of claims 1 to 21, characterized in that. 23. The second light guiding means, the second modulating means, and the measured object placing means are fixed to each other by fixing means formed between them. The optical device according to any one of claims 1 to 20. 24. A fixing means formed between the second light guiding means and the second modulating means, and a fixing means formed between the second light guiding means and the object mounting means. At least one of the fixing means is formed of a material that releases the fixation of the upper and lower parts when heat is applied.
The optical device according to item 3. 25. The optical device according to claim 1, wherein the measured object placing means is a glass substrate, and the measured object is a DNA probe. 26. The object to be measured, which is used in the optical device according to any one of claims 1 to 25, which functions as an object-to-be-measured mounting means for mounting the object to be measured. Placed parts. 27. A polarization converting means for converting the polarization state of light from the light source means, a light guiding means for guiding the light emitted from the polarization converting means in a predetermined direction, and a light guiding means for guiding the light. Modulation means for modulating the polarization state of the light being emitted at a predetermined position in the predetermined direction, and transmission for controlling the transmission and reflection of the light formed on the surface of the light guide means according to the polarization state of the light. A reflection control means, wherein the modulation means includes a liquid crystal layer composed of a plurality of liquid crystal cells arranged in the predetermined direction, and a surface of the liquid crystal layer on a side on which the light guide means is formed. And a reflection means formed on a surface opposite to the surface, and the polarization state of the light is modulated at a predetermined position in the predetermined direction by applying a voltage to the liquid crystal cell at the predetermined position. A light emission position control device. 28. Light guiding means for guiding light emitted from a light source means in a predetermined direction, and guiding the light guiding means by modulating a refractive index at a predetermined position in the predetermined direction. The light that enters the modulator, and the light that guides the light incident on the modulator formed on the surface of the modulator that is opposite to the side on which the light guide is formed. And a reflecting means for reflecting to the means side, wherein the modulating means comprises a liquid crystal layer composed of a plurality of liquid crystal cells arranged in the predetermined direction, by applying a voltage to the liquid crystal cell at a predetermined position in the predetermined direction. A light emission position control device, wherein the refractive index of the liquid crystal cell is modulated at a predetermined position in the predetermined direction. 29. The optical device according to claim 1, storage means for storing comparison information for comparison with measurement information output from the optical device, and the optical device. An analysis system, comprising: an analysis device for analyzing an object to be measured based on measurement information output from the device and comparison information stored in the storage means. 30. A personal identification method using the analysis system according to claim 29, wherein the optical device measures genetic information of a user to obtain measurement information, and the storage unit stores genetic information indicating an identity of the user. Is stored as comparison information, and the analysis device collates the person based on the gene information measured by the optical device and the gene information indicating the person stored in the storage means. Matching method. 31. An allergy / side effect inspection method using the analysis system according to claim 29, wherein the optical device measures genetic information of a user to obtain measurement information, and the storage means stores allergy / side effects. Is stored as comparison information, the analysis device is based on the gene information measured by the optical device and the allergy / side effect-generating group information stored in the storage means. A method for testing allergies and side effects, which comprises testing