JP2003261594A - Disodium 5'-xanthylate crystal - Google Patents
Disodium 5'-xanthylate crystalInfo
- Publication number
- JP2003261594A JP2003261594A JP2002062178A JP2002062178A JP2003261594A JP 2003261594 A JP2003261594 A JP 2003261594A JP 2002062178 A JP2002062178 A JP 2002062178A JP 2002062178 A JP2002062178 A JP 2002062178A JP 2003261594 A JP2003261594 A JP 2003261594A
- Authority
- JP
- Japan
- Prior art keywords
- xanthylic acid
- crystals
- disodium salt
- crystal
- xanthylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Saccharide Compounds (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、呈味物質として有
用な５'−キサンチル酸・２ナトリウム塩の結晶に関す
る。TECHNICAL FIELD The present invention relates to crystals of 5'-xanthylic acid disodium salt useful as a taste substance.
【０００２】[0002]
【従来の技術】５'−キサンチル酸またはその塩は、呈
味物質として有用であり、その製造法として特公昭４０
−２４５１５号、特公昭４５−１１１１５号、特開平４
−２６２７９０号等に記載の発酵生産法が知られてい
る。公知の５'−キサンチル酸およびその塩、ならびに
市販の５'−キサンチル酸・２ナトリウム塩は、凍結乾
燥、溶媒沈殿等の操作により得られているため、非晶性
アモルファスである。これらの非晶性アモルファスは、
吸湿性、潮解性等があり、安定性に問題があることが知
られている。そのため、例えば保存、輸送、流通等にお
いて冷蔵もしくは冷凍するか、または包装する際に防湿
対策が必要であり、工業レベルでの大量供給には、常温
で保存可能な５'−キサンチル酸またはその塩の結晶が
求められる。2. Description of the Related Art 5'-Xanthylic acid or a salt thereof is useful as a taste substance, and its production method is disclosed in Japanese Examined Patent Publication No.
No. 24515, Japanese Examined Patent Publication No. 45-11115, Japanese Patent Laid-Open No. Hei 4
Fermentation production methods described in, for example, No. -262790 are known. Known 5'-xanthylic acid and its salt, and commercially available 5'-xanthylic acid disodium salt are amorphous amorphous since they are obtained by operations such as lyophilization and solvent precipitation. These amorphous amorphous are
It has hygroscopicity and deliquescent, and is known to have a problem with stability. Therefore, for example, it is necessary to take moisture-proof measures when refrigerating or freezing during storage, transportation, distribution, etc., or when packaging, and for large-scale supply at an industrial level, 5'-xanthylic acid or a salt thereof that can be stored at room temperature is stored. Is required.
【０００３】また、特公昭４０−２４５１５号および特
開平４−２６２７９０号に、それぞれ５'−キサンチル
酸結合蛋白結晶、ならびに５'−キサンチル酸・バリウ
ム塩および５'−キサンチル酸・２ナトリウム塩・７水
和物の結晶という記載がある。しかし、５'−キサンチ
ル酸・バリウム塩および５'−キサンチル酸・２ナトリ
ウム塩・７水和物の結晶について、取得法に関する詳細
な記載、明確な結晶性を証明する記載および保存等で問
題となる安定性に関する記載はない。In Japanese Patent Publication No. 40-24515 and JP-A-4-262790, 5'-xanthylic acid-binding protein crystals, 5'-xanthylic acid-barium salt and 5'-xanthylic acid-disodium salt, respectively. There is a description of crystals of heptahydrate. However, regarding crystals of 5'-xanthylic acid-barium salt and 5'-xanthylic acid-disodium salt heptahydrate, there is a problem in detailed description regarding the acquisition method, description demonstrating clear crystallinity and storage. There is no description regarding stability.
【０００４】[0004]
【発明が解決しようとする課題】本発明の目的は、呈味
物質として有用な５'−キサンチル酸を吸湿性が低く安
定性に優れた５'−キサンチル酸・２ナトリウム塩の結
晶として提供することにある。The object of the present invention is to provide 5'-xanthylic acid, which is useful as a tastant, as crystals of 5'-xanthylic acid disodium salt having low hygroscopicity and excellent stability. Especially.
【０００５】[0005]
【課題を解決するための手段】本発明は、５'−キサン
チル酸・２ナトリウム塩の結晶およびその製造法に関す
る。５'−キサンチル酸・２ナトリウム塩の結晶の中で
も、５'−キサンチル酸・２ナトリウム塩・ｎ水和物
（式中、ｎは０以上７未満の整数または分数を表す）の
結晶が好ましく、さらには５'−キサンチル酸・２ナト
リウム塩・６水和物の結晶、５'−キサンチル酸・２ナ
トリウム塩・３水和物の結晶または５'−キサンチル酸
・２ナトリウム塩・無水和物の結晶が好ましい。The present invention relates to crystals of 5'-xanthylic acid disodium salt and a process for producing the same. Among the crystals of 5'-xanthylic acid disodium salt, crystals of 5'-xanthylic acid disodium salt n hydrate (wherein n represents an integer of 0 or more and less than 7 or a fraction), Further, crystals of 5'-xanthylic acid disodium salt hexahydrate, crystals of 5'-xanthylic acid disodium salt trihydrate or crystals of 5'-xanthylic acid disodium salt anhydrate. Crystals are preferred.
【０００６】[0006]
【発明の実施の形態】本発明において、５'−キサンチ
ル酸・２ナトリウム塩の結晶はどのような結晶でもよい
が、例えば、柱状、板状、針状等の結晶があげられ、と
りわけ柱状の結晶が好ましく、水和物、アセトン、メタ
ノールもしくはエタノール等の溶媒和物等も５'−キサ
ンチル酸・２ナトリウム塩の結晶に包含される。BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the crystals of 5'-xanthylic acid disodium salt may be any crystals, and examples thereof include columnar, plate-like, and needle-like crystals, and particularly columnar crystals. Crystals are preferable, and hydrates, solvates of acetone, methanol, ethanol and the like are also included in the crystals of 5'-xanthylic acid disodium salt.
【０００７】次に、５'−キサンチル酸・２ナトリウム
塩の結晶の製造法について説明する。
製造法：５'−キサンチル酸・２ナトリウム塩の水溶液
を、例えば濃縮等により、１００ｇ／Ｌ〜６００ｇ／Ｌ
の濃度、好ましくは３００ｇ／Ｌ〜５００ｇ／Ｌの濃度
に調整する。この濃度を調整した水溶液に、必要に応じ
て例えば塩化ナトリウム、硫酸ナトリウム等の無機塩、
アセトン、メタノール、エタノール等の貧溶媒等を添加
し、種晶の存在下または非存在下、−２０℃から４０℃
の間の温度で、好ましくは０℃から４０℃の間の温度
で、１２時間〜７２時間、静置または攪拌により晶析し
て、５'−キサンチル酸・２ナトリウム塩の結晶を析出
させる。このとき、必要に応じて晶析操作の前に、溶液
を４０℃から１００℃の間の温度で、好ましくは５０℃
から７０℃の間の温度で、１分間〜１時間、加熱攪拌し
てもよい。析出した５'−キサンチル酸・２ナトリウム
塩の結晶を濾過し、減圧下または通風下で取得した結晶
を乾燥することにより、５'−キサンチル酸・２ナトリ
ウム塩の結晶を得ることができる。Next, a method for producing crystals of 5'-xanthylic acid disodium salt will be described. Production method: 100 g / L to 600 g / L of an aqueous solution of 5'-xanthylic acid disodium salt, for example, by concentration.
Is adjusted to a concentration of preferably 300 g / L to 500 g / L. An aqueous solution having this concentration adjusted, if necessary, for example, sodium chloride, an inorganic salt such as sodium sulfate,
Add a poor solvent such as acetone, methanol, or ethanol, and in the presence or absence of seed crystals, -20 ° C to 40 ° C.
At a temperature of between 0 ° C. and 40 ° C. for 12 hours to 72 hours to allow crystallization by standing or stirring to precipitate crystals of 5′-xanthylic acid disodium salt. At this time, if necessary, the solution may be heated to a temperature between 40 ° C. and 100 ° C., preferably 50 ° C., before the crystallization operation.
You may heat-stir at the temperature between 1 to 70 degreeC for 1 minute-1 hour. The precipitated crystals of 5'-xanthylic acid disodium salt are filtered, and the crystals obtained under reduced pressure or under ventilation are dried to obtain crystals of 5'-xanthylic acid disodium salt.
【０００８】このとき、乾燥時間、乾燥方法、乾燥温度
等を変えることにより、異なる水和物数の５'−キサン
チル酸・２ナトリウム塩の結晶を得ることができる。例
えば常圧下、２０℃から６０℃の間の温度で通風乾燥す
ることにより、５'−キサンチル酸・２ナトリウム塩・
６水和物の結晶を得ることができ、例えば４０℃から１
３０℃の間の温度で、通風下もしくは静置で常圧下、乾
燥するか、または減圧乾燥することにより、５'−キサ
ンチル酸・２ナトリウム塩・無水和物の結晶を得ること
ができる。At this time, crystals of 5'-xanthylic acid disodium salt having different numbers of hydrates can be obtained by changing the drying time, drying method, drying temperature and the like. For example, 5'-xanthylic acid / disodium salt /
Crystals of hexahydrate can be obtained, for example from 40 ° C to 1
The crystals of 5'-xanthylic acid / disodium salt / anhydrous salt can be obtained by drying under atmospheric pressure or at a temperature of 30 ° C under atmospheric pressure or by drying under reduced pressure.
【０００９】また、さらに洗浄、乾燥、再結晶等の操作
を行うことにより、さらに精製することもできる。５'
−キサンチル酸・２ナトリウム塩の水溶液は、市販の
５'−キサンチル酸・２ナトリウム塩の非晶性アモルフ
ァスを水に溶解して調製してもよいが、例えば既知の方
法（例えば、特公昭４０−２４５１５号等）に準じて、
発酵法等により得られる５'−キサンチル酸の反応液、
培養液、または除菌液を精製した５'−キサンチル酸の
水溶液から調製することもできる。Further, further purification can be carried out by further performing operations such as washing, drying and recrystallization. 5 '
An aqueous solution of -xanthylic acid disodium salt may be prepared by dissolving a commercially available amorphous amorphous 5'-xanthylic acid disodium salt in water. For example, a known method (for example, Japanese Patent Publication No. No. 24515, etc.)
A reaction solution of 5'-xanthylic acid obtained by a fermentation method,
It is also possible to prepare a culture solution or a sterilized solution from a purified 5'-xanthylic acid aqueous solution.
【００１０】例えば、５'−キサンチル酸の水溶液を、
例えば水酸化ナトリウム、炭酸水素ナトリウム、炭酸ナ
トリウム、ナトリウムエトキシド、ナトリウムメトキシ
ド等のナトリウム含有塩基で、ｐＨ６．０〜７．０、好
ましくはｐＨ６．３〜６．８に調整することにより、
５'−キサンチル酸・２ナトリウム塩の水溶液を得るこ
とができる。このとき、水溶液中に、例えばアセトン、
メタノール、エタノール等が含まれていてもよい。For example, an aqueous solution of 5'-xanthylic acid is
For example, by adjusting the pH to 6.0 to 7.0, preferably pH 6.3 to 6.8 with a sodium-containing base such as sodium hydroxide, sodium hydrogen carbonate, sodium carbonate, sodium ethoxide, and sodium methoxide,
An aqueous solution of 5'-xanthylic acid disodium salt can be obtained. At this time, in the aqueous solution, for example, acetone,
Methanol, ethanol, etc. may be contained.
【００１１】５'−キサンチル酸の水溶液を得るための
精製法としては、例えば膜処理、ゲル濾過処理、活性炭
処理、イオン交換樹脂処理、合成吸着樹脂処理、溶媒沈
殿等、好ましくは活性炭処理、イオン交換樹脂処理、合
成吸着樹脂処理、溶媒沈殿等、さらに好ましくはイオン
交換樹脂処理、合成吸着樹脂処理等があげられる。ま
た、上記製造法で得られる５'−キサンチル酸・２ナト
リウム塩の結晶には、異なった結晶形または異なった粒
度のものが存在する場合もあり、これらが単独でまたは
混合物として得られることもあるが、これらも本発明に
包含される。As a purification method for obtaining an aqueous solution of 5'-xanthylic acid, for example, membrane treatment, gel filtration treatment, activated carbon treatment, ion exchange resin treatment, synthetic adsorption resin treatment, solvent precipitation, etc., preferably activated carbon treatment, ions Exchange resin treatment, synthetic adsorption resin treatment, solvent precipitation and the like, more preferably ion exchange resin treatment, synthetic adsorption resin treatment and the like. In addition, the crystals of 5'-xanthylic acid disodium salt obtained by the above production method may have different crystal forms or different particle sizes, and these may be obtained alone or as a mixture. However, these are also included in the present invention.
【００１２】次に、本発明の５'−キサンチル酸・２ナ
トリウム塩の結晶の保存安定性について、試験例により
具体的に説明する。
試験例１：５'−キサンチル酸・２ナトリウム塩の結晶
と非晶性アモルファスの吸湿性の比較
実施例１で得られた６水和物である５'−キサンチル酸
・２ナトリウム塩の結晶と市販の非晶性アモルファスに
ついて、相対湿度８６％、２３℃で、重量変化を追跡
し、吸湿による水分増加率を求めた。その結果を第１表
に示す。Next, the storage stability of crystals of the 5'-xanthylic acid disodium salt of the present invention will be specifically described with reference to test examples. Test Example 1: Comparison of 5'-xanthylic acid disodium salt crystals and amorphous amorphous hygroscopicity 5'-xanthylic acid disodium salt crystals which are the hexahydrate obtained in Example 1 With respect to the commercially available amorphous amorphous, the weight change was traced at a relative humidity of 86% and 23 ° C., and the moisture increase rate due to moisture absorption was obtained. The results are shown in Table 1.
【００１３】[0013]
【表１】 [Table 1]
【００１４】その結果、５'−キサンチル酸・２ナトリ
ウム塩・６水和物の結晶は、非晶性アモルファスと比較
して、吸湿性が極めて低いことが判明した。以下に、本
発明を実施例によりさらに具体的に説明するが、本発明
はこれらの実施例に何ら限定されるものではない。As a result, it was found that the crystals of 5'-xanthylic acid disodium salt hexahydrate have extremely low hygroscopicity as compared with amorphous amorphous. Hereinafter, the present invention will be described more specifically with reference to Examples, but the present invention is not limited to these Examples.
【００１５】[0015]
【実施例】実施例１：５'−キサンチル酸・２ナトリウ
ム塩・６水和物の結晶
市販の５'−キサンチル酸・２ナトリウム塩（ヤマサ醤
油）を水に溶解して、５'−キサンチル酸・２ナトリウ
ム塩の水溶液５ｍＬ（４００ｇ／Ｌ、ｐＨ６．５）を調
製した。この水溶液中に塩化ナトリウム添加して、飽和
状態にした。その後、この水溶液を６０℃に加温して、
同温度で２分間保持した後、静置状態にて常温まで放冷
し、結晶を析出させた。さらに２４時間静置した後、析
出した結晶を濾取した。この結晶を２３℃で通風乾燥
し、５'−キサンチル酸・２ナトリウム塩・６水和物の
結晶０．６ｇを得た。Example 1 Crystal of 5'-xanthylic acid disodium salt hexahydrate Commercially available 5'-xanthylic acid disodium salt (Yamasa soy sauce) was dissolved in water to prepare 5'-xanthyl salt. 5 mL (400 g / L, pH 6.5) of an aqueous solution of an acid disodium salt was prepared. Sodium chloride was added to this aqueous solution to make it saturated. Then, this aqueous solution is heated to 60 ° C.,
After holding at the same temperature for 2 minutes, it was left standing to cool to room temperature to precipitate crystals. After standing still for 24 hours, the precipitated crystals were collected by filtration. The crystals were blow-dried at 23 ° C. to obtain 0.6 g of 5′-xanthylic acid • disodium salt • hexahydrate crystals.
【００１６】
ナトリウム含量：１２．６％（原子吸光測定法）
水分含量：２０．４％（カールフィッシャー法）
粉末Ｘ線回折［回折角（２θo）、( )内は相対強度比
（Ｉ／Ｉ0）を示す］：7.60 (16), 12.15 (18), 15.35
(19), 17.45 (14), 19.75 (39), 20.65 (12), 22.70 (1
7), 27.15 (18), 31.50 (100), 32.35 (14), 36.35 (1
2), 37.70 (13),45.25 (56), 47.85 (13), 56.30 (17)Sodium content: 12.6% (atomic absorption measurement method) Moisture content: 20.4% (Karl Fischer method) Powder X-ray diffraction [diffraction angle (2θ o ), relative intensity ratio (I / I 0 )]: 7.60 (16), 12.15 (18), 15.35
(19), 17.45 (14), 19.75 (39), 20.65 (12), 22.70 (1
7), 27.15 (18), 31.50 (100), 32.35 (14), 36.35 (1
2), 37.70 (13), 45.25 (56), 47.85 (13), 56.30 (17)
【００１７】実施例２：５'−キサンチル酸・２ナトリ
ウム塩・無水和物の結晶
実施例１で得られた５'−キサンチル酸・２ナトリウム
塩・６水和物の結晶を、１０５℃で１５時間、常圧で乾
燥することにより５'−キサンチル酸・２ナトリウム塩
・無水和物の結晶を得た。
水分含量：０．１％（カールフィッシャー法）Example 2: Crystal of 5'-xanthylic acid disodium salt anhydrate The crystal of 5'-xanthylic acid disodium salt hexahydrate obtained in Example 1 was stored at 105 ° C. The crystals of 5'-xanthylic acid / disodium salt / anhydrous were obtained by drying at atmospheric pressure for 15 hours. Water content: 0.1% (Karl Fischer method)
【００１８】実施例３：５'−キサンチル酸・２ナトリ
ウム塩・６水和物の結晶
特公昭４０−０２４５１５号に記載の方法に準じて、
５'−キサンチル酸の反応液を得た。この反応液を遠心
分離により除菌した後、ダイヤイオンＰＡ−４１２（Ｃ
ｌ型：三菱化学製）に吸着させ、塩酸で５'−キサンチ
ル酸を溶出させた。この溶出液をダイヤイオンＳＫ−１
０４（Ｈ型：三菱化学製）に吸着させ、水で５'−キサ
ンチル酸画分を分離した後、５'−キサンチル酸画分を
ピュロライトＡ−１００（ＯＨ型：ピュロライト社製）
に吸着させ、水酸化ナトリウム水溶液で５'−キサンチ
ル酸を溶出した。得られた溶出液を水酸化ナトリウムで
ｐＨ６．５に調整し、減圧下で濃縮することにより５'
−キサンチル酸・２ナトリウム塩の水溶液（４００ｇ／
Ｌ、６０ｍＬ）を得た。得られた５'−キサンチル酸・
２ナトリウム塩の水溶液に、実施例１で得られた６水和
物である５'−キサンチル酸・２ナトリウム塩・６水和
物の結晶を種晶として０．２４ｇ添加し、２４時間攪拌
した。析出した結晶を濾取した後、実施例１と同様に通
風乾燥を行い、５'−キサンチル酸・２ナトリウム塩・
６水和物の結晶６ｇを得た。得られた結晶の物性は、実
施例１に示す結晶と同等のものであった。Example 3: Crystals of 5'-xanthylic acid / disodium salt / hexahydrate According to the method described in JP-B-40024515.
A reaction solution of 5'-xanthylic acid was obtained. After sterilizing this reaction solution by centrifugation, Diaion PA-412 (C
l-type: manufactured by Mitsubishi Kagaku Co., Ltd.), and 5′-xanthylic acid was eluted with hydrochloric acid. This eluate is Diaion SK-1
04 (H type: manufactured by Mitsubishi Kagaku Co., Ltd.), the 5'-xanthylic acid fraction was separated with water, and then the 5'-xanthylic acid fraction was separated from Purolite A-100 (OH type: manufactured by Purolite).
And 5'-xanthylic acid was eluted with an aqueous sodium hydroxide solution. The obtained eluate was adjusted to pH 6.5 with sodium hydroxide and concentrated under reduced pressure to obtain 5 '.
-Aqueous solution of xanthylic acid disodium salt (400 g /
L, 60 mL) was obtained. The obtained 5'-xanthylic acid
To the aqueous solution of the disodium salt, 0.24 g of crystals of the hexahydrate of 5'-xanthylic acid / disodium salt / hexahydrate obtained in Example 1 was added as a seed crystal and stirred for 24 hours. . The precipitated crystals were collected by filtration, and then air-dried in the same manner as in Example 1 to give 5′-xanthylic acid · disodium salt ·
6 g of crystals of hexahydrate were obtained. The physical properties of the obtained crystal were similar to those of the crystal shown in Example 1.
【００１９】[0019]
【発明の効果】本発明により、呈味物質として有用な
５'−キサンチル酸を、吸湿性が低く安定性に優れた５'
−キサンチル酸・２ナトリウム塩の結晶として提供する
ことができる。INDUSTRIAL APPLICABILITY According to the present invention, 5'-xanthylic acid, which is useful as a tastant, has a low hygroscopic property and excellent stability.
-Can be provided as crystals of xanthylic acid disodium salt.
Claims (6)
結晶。1. Crystals of 5'-xanthylic acid disodium salt.
結晶が５'−キサンチル酸・２ナトリウム塩・ｎ水和物
（式中、ｎは０以上７未満の整数または分数を表す）で
ある請求項１記載の結晶。2. Crystals of 5'-xanthylic acid disodium salt are 5'-xanthylic acid disodium salt n hydrate (wherein n represents an integer of 0 or more and less than 7 or a fraction). The crystal according to claim 1.
水溶液を１００ｇ／Ｌ〜６００ｇ／Ｌの濃度に調整し、
晶析により５'−キサンチル酸・２ナトリウム塩の結晶
を析出させることを特徴とする請求項１記載の結晶の製
造法。6. An aqueous solution of 5'-xanthylic acid disodium salt is adjusted to a concentration of 100 g / L to 600 g / L,
The method for producing crystals according to claim 1, wherein crystals of 5'-xanthylic acid disodium salt are precipitated by crystallization.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002062178A JP2003261594A (en) | 2002-03-07 | 2002-03-07 | Disodium 5'-xanthylate crystal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002062178A JP2003261594A (en) | 2002-03-07 | 2002-03-07 | Disodium 5'-xanthylate crystal |
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| JP2003261594A true JP2003261594A (en) | 2003-09-19 |
| JP2003261594A5 JP2003261594A5 (en) | 2005-07-28 |
Family
ID=29196081
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| Application Number | Title | Priority Date | Filing Date |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3475409A (en) * | 1966-07-14 | 1969-10-28 | Asahi Chemical Ind | Process for preparing ribonucleoside-5'-monophosphate |
| JPH03215494A (en) * | 1989-09-04 | 1991-09-20 | Ajinomoto Co Inc | Production of 5'-guanylic acid disodium and 5'-inosinic acid disodium mixed crystal |
| JPH03223299A (en) * | 1990-01-27 | 1991-10-02 | Ajinomoto Co Inc | Production of disodium 5'-guanylate. disodium 5'-inosinate mixed crystal |
| JPH04262790A (en) * | 1991-02-19 | 1992-09-18 | Kyowa Hakko Kogyo Co Ltd | Production of 5'-xanthylic acid by fermentation |
| JPH06336488A (en) * | 1993-05-27 | 1994-12-06 | Ajinomoto Co Inc | Method for selectively crystallizing 2 hydrate and 2.5 hydrate of guanosine monosodium salt |
-
2002
- 2002-03-07 JP JP2002062178A patent/JP2003261594A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3475409A (en) * | 1966-07-14 | 1969-10-28 | Asahi Chemical Ind | Process for preparing ribonucleoside-5'-monophosphate |
| JPH03215494A (en) * | 1989-09-04 | 1991-09-20 | Ajinomoto Co Inc | Production of 5'-guanylic acid disodium and 5'-inosinic acid disodium mixed crystal |
| JPH03223299A (en) * | 1990-01-27 | 1991-10-02 | Ajinomoto Co Inc | Production of disodium 5'-guanylate. disodium 5'-inosinate mixed crystal |
| JPH04262790A (en) * | 1991-02-19 | 1992-09-18 | Kyowa Hakko Kogyo Co Ltd | Production of 5'-xanthylic acid by fermentation |
| JPH06336488A (en) * | 1993-05-27 | 1994-12-06 | Ajinomoto Co Inc | Method for selectively crystallizing 2 hydrate and 2.5 hydrate of guanosine monosodium salt |
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