JP2003250806A - Liquid medicine applicator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid medicine applicator capable of freely changing the direction of the liquid medicine discharge port provided to the leading end of the applicator in a three-dimensional manner by hand operation and capable of adapting the direction of the liquid medicine discharge port to a target region without largely moving the position of a tissue in a natural state. <P>SOLUTION: The liquid medicine applicator is equipped with a liquid medicine injection inner pipe 10 comprising one hard pipe or two parallel hard pipes, the inner pipe base provided to the base end of the liquid medicine injection inner pipe 10 and connected to a syringe housing a liquid medicine or the like, a liquid medicine injection outer pipe 30 comprising a flexible tube having an inner diameter almost equal to the outer diameter of the liquid medicine injection inner pipe 10 and curved at the leading end part thereof to be formed into a J-shape and a means for integrating the liquid medicine injection outer pipe 30. The liquid medicine injection inner pipe 10 is inserted in the inner lumen of the liquid medicine injection outer pipe 30 to form a double pipe and the leading end part of the liquid medicine injection outer pipe 30 can be freely changed to a curved shape within a linear range from the J-shape by an insertion degree. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drug solution applying device for applying a drug solution to the internal tissue of a living body during surgery or the like,
More specifically, it is particularly suitable for endoscopic surgery, and a bioadhesive used by mixing two components for hemostasis or suturing substitute for incised tissue or the like, or other one-liquid or two-liquid mixed drug solution The present invention relates to a drug solution applicator such as a bioadhesive for applying to internal tissues.

[0002]

2. Description of the Related Art As a device for applying a drug solution to a tissue inside a living body, for example, there is a device for applying a bioadhesive agent used for the purpose of hemostasis to an affected area such as an incised tissue, substitute for suture, or assisting suture. These are used by mixing two components, for example, a fibrinogen-containing solution and a thrombin-containing solution, and an applicator particularly suitable for this application is widely known. For example, Japanese Patent Laid-Open No. 64-2584
There are 3 etc., basically, a syringe containing A solution and B solution respectively is provided, and the plungers of each syringe are integrated so that two drug solutions can be simultaneously dispensed, and an appropriate length is provided at the tip of each syringe. The chemical liquid passages (nozzles) are arranged in parallel or concentrically, and the chemical liquid is discharged from the tip of each passage (nozzle) and mixed and applied at the tip. Many of these devices have separate passages for each drug solution because the two components of the adhesive harden in a short time when they are mixed. Therefore, after discharging from the device, they are mixed externally and then inside the device. Care is taken to prevent premature curing.

Further, as an instrument to which the present invention is applied, which is particularly suitable for endoscopic surgery, for example, Jpn.
98, etc., which also have basically the same structure as the above instrument, but in consideration of use in endoscopic surgery, a tubular body serving as a drug solution passage has a length suitable for the purpose. ,
For example, when using a tube with two through holes, etc., there is a convenient way to insert the instrument into the body cavity through a mantle tube (trocar) that serves as an insertion passage for the instrument, and there is no gas leakage during pneumoperitoneum surgery. It has been proposed to consider an airtight structure that does not occur.

[0004]

Here, looking at actual endoscopic surgery, the field of view is limited to the range that can be displayed by the endoscope. Move the tissue with forceps etc. to change the angle,
The current situation is that the operation is advanced by turning it over and moving the surgical target site within the field of view of the endoscope. However, bioadhesives are often used at the final stage of surgery as a substitute for suturing as described above, and in this case, from the viewpoint of preventing adhesion with other tissues, the tissue is not moved by forceps or the like. Instead, it is said that it is desirable to place it in a natural state for treatment (adhesion). However, in the conventional instruments as described above, the tip of the instrument may not be operated from outside the body even if it is straight or bent.
Also, since the bend is limited, the direction of the chemical solution discharge port provided at the tip of the chemical solution injection pipe (the range in which the chemical solution can be applied) should be set when the tool is inserted into the trocar. Is limited to a two-dimensional surface within the movable range, and, for example, when an organ is in a natural state and there is a surgical target site on the back side of the trocar insertion side (drug application device insertion side). However, there are situations in which it is not possible to adapt, and it is necessary to move and hold the target site of the tissue to the surface side and perform surgery carefully.

Further, as described above, the bioadhesive mixed with two chemicals has a property of curing in a very short time when the two chemicals are mixed, and this property is an excellent property as an adhesive. For the instruments that handle the above, it causes a problem that the chemical liquid hardens at the discharge port part of the tip when used for a long time.If the cured product blocks the nozzle of the instrument, the instrument must be replaced. There are situations where you shouldn't.

In view of this, the present invention makes it possible to freely change the direction of the drug solution discharge port at the distal end of the instrument three-dimensionally by hand operation so as to be particularly suitable for endoscopic surgery.
An object of the present invention is to provide a drug solution applicator that can adjust the direction of a drug solution outlet to a target site without significantly moving the position of a tissue (organ or the like) in a natural state.

It is another object of the present invention to provide a drug solution applying device which does not require replacement of the device even if the drug solution outlet is blocked by the mixed drug solution.

[0008]

Means for Solving the Problems A chemical solution applying device of the present invention is provided with a chemical solution injection inner tube made of a hard pipe such as a stainless pipe and serving as a path for the chemical solution, and provided at a proximal end portion of the chemical solution injection inner tube. An inner tube base connected to a syringe to be stored,
A flexible tube having an inner diameter substantially equal to the outer diameter of the drug solution injecting tube and having a curved J-shape with its tip portion curved to form a drug solution passage along with the drug solution injecting tube. The inner tube of the drug solution injection is inserted into the inner cavity of the outer tube of the drug solution to form a double tube, and the tip of the outer tube of the drug solution is linear from J-shape depending on the progress of the insertion. The shape (curve) can be freely changed within the range.

Further, it is more preferable to provide an outer tube base serving as a gripping and operating section at the base end of the drug solution injecting outer tube of the drug solution applying instrument having the above-mentioned configuration.

Further, it is possible to mix and apply two kinds of chemicals,
Basically, two hard pipes, such as a stainless steel pipe, are provided in parallel and adjacent to each other as a device for installing the two devices in parallel, and a first drug solution injecting pipe and a second drug solution injecting pipe serving as a drug solution passage. A first inner tube group and a second inner tube group, which are provided at respective base end portions of the first and second drug solution injecting inner tubes and are connected to a syringe or the like for accommodating the drug solution, respectively; A liquid chemical injection inner tube, and means for integrating the first and second inner tube groups,
Two flexible tubes having an inner diameter substantially equal to the outer diameters of the first and second chemical liquid injection inner pipes and formed by curving the distal end portion into a J shape are provided adjacently in parallel. A first chemical liquid injection outer pipe and a second chemical liquid injection outer pipe, which are to be a passage for the chemical liquid together with the first and second chemical liquid injection inner pipes, and means for integrating the first and second chemical liquid injection outer pipes. The first and second drug solution injecting inner tubes are respectively inserted into the lumens of the first and second drug solution injecting outer tubes to form double tubes, respectively, and the first and second drug solution injecting tubes are formed according to the progress of the insertion. (2) The configuration is such that the tip (end) of the outer tube for injecting a chemical liquid can be integrally synchronized and freely changed in shape (curvature) from the J shape to the linear shape.

The above-mentioned first and second chemical liquid injection inner tubes,
Also, as a means for integrating the first and second inner tube groups, a connecting section for connecting and fixing the first and second inner tube groups and a syringe holding section for fixing a syringe attached to the rear end of the inner tube group. And a housing that includes a syringe pressing portion that integrates the plungers of the respective syringes and a grip portion that operates the device so that the two chemicals can be simultaneously dispensed. It was constructed by being provided at the base of the inner tube for injecting two chemicals.

As a means for unifying the first and second chemical liquid injection outer pipes described above, the tip end is curved in the same manner as the first and second chemical liquid injection outer pipes, and has a J shape. And a means for airtightly covering and integrating the first and second chemical liquid injection outer pipes in a state where they are adjacent to each other in parallel with a coating tube made of a flexible resin, and base end portions of the first and second chemical liquid injection outer pipes. And a means for connecting to one outer tube group that can be connected together, or either means.

Further, the first and second outer cylinder tubes are inserted into the inner cavities of the straight portions (non-curved portions) of the first and second chemical liquid injection outer tubes and the coating tube, and the first and second outer cylinder tubes are provided with a base portion. The chemical liquid injection outer tube, the covering tube, and the outer tube were integrated with each other.

The above-mentioned outer tube for injecting a chemical liquid or the first and second tubes
The J-shaped curve formed in advance in the chemical liquid injection outer tube is configured such that the angle formed by the extension line of the tip discharge port is 90 ° or more and 180 ° or less with respect to the axis of the straight portion of the chemical liquid injection outer pipe. .

Further, the chemical liquid injection outer pipe or the first and second chemical liquid injection outer pipes having an outer diameter of 1 mm or more and 2 mm or less can be easily cut by a surgical or general cutting instrument such as scissors or a scalpel. It is desirable to form the flexible resin.

[0016]

According to the chemical liquid applicator of this structure, the chemical liquid injection outer tube or the first chemical liquid injection outer tube and the second chemical liquid injection outer tube (hereinafter, Into the curved portion of the outer tube, insert (advance) the drug solution injecting inner tube made of a hard pipe or the first drug solution injecting inner tube and the second drug solution injecting inner tube (hereinafter, inner tube), which are inserted into the outer tube lumen. By doing so, the flexible outer tube is straightened by the hard pipe to gradually reduce the curvature, and becomes linear when inserted up to the tip. On the other hand, when the inner tube is retracted from the outer tube in the inserted state, the flexible outer tube does not have the influence of the hard pipe, and the curvature is gradually deepened so that the tip of the inner tube is a straight part of the outer tube. When it reaches the (non-curved portion), it returns to the pre-formed J shape, and therefore, depending on the insertion progress of the inner tube into the outer tube, the preformed J shape is linear (for example, the axis of the outer tube and the tip portion of the outer tube). The angle of the extended line of the chemical solution outlet is in the range of 180 degrees when the shape is J to 0 degrees when the shape is straight), that is, the angle between the chemical solution outlet at the tip of the outer tube and the axis of the outer tube is freely adjustable. Can be changed. Further, due to this action, since the instrument may be linearized when it is inserted into or removed from the trocar, the instrument can be easily inserted into the abdominal cavity during endoscopic surgery.

Further, the above-mentioned shape changing operation is easy by simply moving the base portions of the outer tube and the inner tube closer to and farther from each other while looking at the endoscopic image. The direction of the discharge port can be freely and easily changed in a three-dimensional range by a combination of a dynamic operation and an operation such as the inclination with respect to the body surface and the insertion depth that can be performed within the movable range of the instrument with the trocar attached. Can be made.

Further, means for improving the operability by providing an outer tube base at the base end portion of the outer tube, and by providing an outer tube tube around the outer circumference of the outer tube to achieve compatibility with the trocar and to integrate the means. By providing the device, it is possible to provide an instrument excellent in operability which is particularly suitable for endoscopic surgery such as insertion into a trocar and holding.

When this device is used for applying a bioadhesive or the like of a mixture of two chemicals under an endoscope, the outer tube has a metal or two through holes as conventionally used for the purpose. It is not a tube with a large outer diameter, but rather a relatively small diameter resin that can be easily cut with a cutting tool that is commonly used in operating rooms, etc. Even if there is, once the closed part of the tip is cut, it can be used for a long time without replacing the instrument.

[0020]

BEST MODE FOR CARRYING OUT THE INVENTION As an embodiment of the present invention, in an endoscopic surgical operation which is an example of a drug solution applying device, 2
A bioadhesive application tool for mixing a chemical solution and applying it to the tissue of the incision will be described in detail with reference to the drawings. In addition, as long as it applies one drug solution, a device with one drug injection tube may be used.

FIG. 1 is an overall constitutional view of a bioadhesive applying instrument of this embodiment, in which A is a front view and B is a side view. The front end side is shown as a drawing enlarged from the base end side. The bioadhesive application tool of the present embodiment has an inner pipe 10 provided with two pipes adjacent to each other in parallel, an inner pipe base 20 provided at the base end of each of the inner pipes 10, and means for integrating these. Housing 5
The inner tube portion formed by 0 and the tip end portion are curved to form J
An outer tube 30 having two tubes of the same shape, which have a particular shape, are provided in contact with each other in parallel, one outer tube base 4 capable of connecting the base ends of the outer tubes 30 together, and the outer tube 30. In order to cover the outer circumference of the outer tube 30 except for a part of the tip, and integrate the outer tube 30,
Similar to the outer tube 30, the tip has a J-shaped coating tube 6, an outer tube 70 that inserts a straight portion (non-curved portion) of the coating tube into an inner cavity, and these portions are integrated at the base end. The outer tube portion is formed by a contraction tube 71 that serves as a means for converting the inner tube portion into the inner cavity of the outer tube 30 of the outer tube portion. And the inner pipe 10
Is inserted into the curved portion 9 of the outer tube 30, the curvature is corrected and the shape is gradually changed from the J-shape to the linear shape, and when the inner tube 10 is pulled back from the inserted linear shape, the inner tube 10 is gradually pulled back. It has a structure that returns from the straight shape to the original J shape.

The inner pipe portion is composed of a first chemical liquid injection inner pipe (hereinafter referred to as liquid A inner pipe) 10A and a second chemical liquid injection inner pipe (hereinafter referred to as liquid B) which are made of a stainless steel pipe having two lumens as passages for the liquid chemicals. (Inner tube) 10B are provided in parallel, and the base end is the barrel tip 82 of the syringe.
(Described later) is connected to the connectable inner pipe bases 20A and 20B, respectively, and is fixed and integrated with the inner pipe base connecting portion 51 of the housing 50. The details of the housing 50 will be described later.

The outer tube portion is preferably 1 mm to 2 mm
A flexible tube having an outer diameter of (1.5 mm in this embodiment) and an inner diameter slightly larger than the outer diameter of the inner tube 10 (in this example, so that the inner tube 10 can be fitted and slid). Is a fluororesin) and has a J-shape (in this example, a curve of 180 degrees with respect to the axis) formed into the J-shaped inner lumen and the inner lumen as a passage for two chemicals. One chemical liquid injection outer pipe (hereinafter, A liquid outer pipe) 30A and a second chemical liquid injection outer pipe (hereinafter, B liquid outer pipe) 30B are provided in contact with each other in parallel, and A liquid outer pipe 30A, B liquid outer pipe 30B Were connected to an outer tube base 4 which could be connected together. In addition, the tip ends of the A liquid outer tube 30A and the B liquid outer tube 30B are an A liquid outer tube discharge port 31A and a B liquid outer tube discharge port 31B as a chemical liquid discharge part when the tip ends are used in a curved state. Become. Further, in the actual production, it is easier to form the curved shape after the outer tube 30 is integrated with the covering tube 6. Further, as a means for integrally connecting the A liquid outer tube 30A and the B liquid outer tube 30B to hold contact to the tip portion, the tip portion is left slightly and the outer periphery of the outer tube 30 is hermetically sealed by the coating tube 6. Coated. In the present example, a heat-shrinkable resin is used for this airtight coating, and a means for inserting the outer tube 30 into the coating tube 6 and heating it for shrinkage and close contact is used. Furthermore,
Considering the application to endoscopic surgery, it is easy to insert it into the trocar, and it is effective in preventing gas leakage, etc.
The sheath tube 6 is attached to the outer tube 70 of a fluorine-based tube.
Of the outer tube 70, the outer tube base 41 and the base end of the outer tube 70 are covered with the shrink tube 71 in order to airtightly integrate these outer tube parts at the base end of the outer tube 70. It was constructed by shrinking and fixing.

FIG. 2 is a front view showing a state in which the inner tube 10 of the device is inserted up to the tip of the outer tube 30. The front end side is shown as a drawing enlarged from the base end side. FIG. 1 shows a state in which the tip portion of the inner pipe 10 is located in a straight line portion immediately before the curved portion 9 of the outer pipe 30, and the tip of the outer pipe 30 is formed in advance.
It has a shape. On the other hand, FIG. 2 shows a state in which the distal end portion of the inner pipe 10 is inserted beyond the curved portion 9 of the outer pipe 30 to the distal end portion,
The tip of the outer tube 30 is linear. At this time, in this example, the tip of the inner tube 10 is slightly projected from the tip of the outer tube 30. In this case, the liquid medicine discharge portion is the liquid A inner tube discharge port 11A which is the tip of each inner tube 10. , B liquid inner tube discharge port 11
It becomes B. Also, in this state, the inner pipe 10 and the outer pipe 3
The length 0 is adjusted so that the front end of the housing 50 is fitted to the rear end of the outer tube base 4.

FIG. 3 shows the straight line portion A--A in FIG.
FIG. 4 shows a sectional view, and FIG. 4 shows a curved portion B- in FIG.
A B sectional view is shown. In the straight line portion, the A liquid inner tube 10A and the B liquid inner tube 10B are slidable so that the A liquid outer tube 30A and the B liquid outer tube 3 can be slid.
The outer tube 30A, 30B is inserted into the inner cavity of the inner tube 0B, and the outer tube 30A, 30B is tightly adhered to the outer tube 30A, 30B, and the outer tube 30 is surrounded by the outer tube 30. It is configured and the passage of the chemical liquid in this straight line portion is
The A liquid inner tube drug solution passage 12A and the B liquid inner tube drug solution passage 12B in the inner tube lumen are responsible. On the other hand, the curved parts are the outer tubes 30A, 30B.
The outer tube 30 is tightly covered with the covering tube 6 to cover the outer tube 30.
A and 30B are integrally formed, and the chemical liquid passage in this curved portion is carried by the A liquid outer pipe chemical liquid passage 32A and the B liquid outer pipe chemical liquid passage 32B in the outer pipe lumen.

FIG. 5 shows a variable operation of the tip portion which is the chemical liquid discharge portion of this embodiment. In A, the tip of the inner pipe 10 is the outer pipe 30.
The outer tube 3 is shown in a state of being located in a straight line portion immediately before the curved portion of
The tip of 0 maintains the J shape formed in advance, and the discharge port 31 of the chemical liquid shows a direction of 180 degrees with respect to the axis of the instrument. B shows the state in which the inner tube 10 is inserted into the curved portion of the outer tube 30 and the tip of the inner tube 10 is located in the middle of the curved portion of the outer tube 30. Is gradually corrected, the curvature is gradually reduced, and the angle of the chemical liquid with respect to the axis of the discharge port 31 is gradually decreased. C inserts the tip of the inner tube 10 to the tip of the outer tube 30 and
Shows a state in which the tip of the outer tube slightly protrudes from the tip of the outer tube 30. The outer tube 30 is straightened, and the medicinal solution discharge port 1
The angle with respect to the axis of 1 is 0 degree. Further, as described above, when the inner pipe 10 is pulled back from the straight state (state of C),
On the contrary, the curve is gradually increased and the state of B is passed, and the inner tube 1
When the 0 tip reaches the straight portion of the outer tube 30, it naturally returns to the preformed J shape (state A). Due to such a variable operation, that is, the progress of insertion of the inner pipe 10 into the outer pipe 30, the J-shaped tips of the A liquid outer pipe 30A and the B liquid outer pipe 30B are integrally synchronized with each other to form the J shape. It is possible to freely change the shape (angle of the discharge port with respect to the axis of the device) in a linear range.

FIG. 6 shows the construction of the inner tube base and the inner tube unifying means of this embodiment. The inner pipes 10A, 10B and the inner pipe bases 20A, 20B need to be integrated at the base in order to maintain the parallel state of the inner pipes, and in this embodiment,
The unifying means is constructed by providing the housing 50 at the base end of the inner tube 10 in consideration of operability. The housing 50 is made of a resin molded product, and is fixed by sandwiching the A liquid inner tube base 20A and the B liquid inner tube base 20B having the A liquid inner tube 10A and the B liquid inner tube 10B adhered to the tips by a molding die above and below the housing. Inner pipe connection part 5
1, a housing holding portion 52 for fixing a syringe 80 to which a barrel tip 81 is fitted and attached to the rear end portion of the inner tube base, and a housing main body having a grip portion 54 for operating the instrument, and a housing It is formed as a separate member from the main body,
A syringe pressing part 53 of a mechanism that integrally presses the plungers 81 of the respective syringes 80 so that the two medicinal liquids can be simultaneously dispensed from the syringes 80 that are slidably inserted in the inner cavity of the housing body. And has a role of integrating the entire inner tube portion and also serves as a supply means and an operating portion for the chemical liquid.

The bioadhesive application instrument of this embodiment is inserted into the body cavity by a trocar which is inserted into the abdominal wall during endoscopic surgery, and the adhesive application target site is seen by observing the image of the endoscope. To adjust the elevation of the inner tube 10 to the outer tube 30 from the outside, adjust the elevation angle, and adjust the direction of the outer tube by turning the outer tube so that the drug solution outlet at the tip of the device is directed toward the target site. It is used by simultaneously discharging two chemicals from a syringe.
The discharged adhesive is mixed and cured after the discharge and functions as an adhesive. Also, in case the adhesive mixes at the tip of the device,
When the outer tube is hardened and the outer tube is blocked, the device may be taken out of the body once, and the closed portion at the tip may be cut with a scalpel or scissors and used again.

[0029]

According to the drug solution applicator of the present invention, as described above, the direction of the ejection port of the tip of the applicator inserted into the abdominal cavity can be controlled by a manual operation from outside the body during endoscopic surgery. Because it can be adjusted three-dimensionally freely, for example,
Discharge in the abdominal cavity that can meet the demands that could not be achieved until now by moving the position of the device or the position of the tissue, such as application of the tissue (organ, etc.) to the back side of the operation surface. Highly flexible in adjusting the direction of parts,
It is possible to provide a drug solution applying device that is particularly suitable for endoscopic surgery.

In addition to the above-mentioned functionality, the structure which is particularly suitable for endoscopic surgery and the ease of operation as described above enable the operator to handle the instrument alone, By eliminating the need for assistants to move tissues, it is possible to reduce the burden on the surgeon and the assistant involved in surgery, and the adhesion that may be injured when the adhesive is applied by inverting the organs. It is possible to provide a drug solution applying device that can reduce the risk to the patient by reducing the adverse effects such as.

Further, as described above, even if the chemical liquid discharge port is closed, the tip portion may be cut off, and it is not necessary to replace the instrument. Therefore, it is economical and suitable for a curable drug. It is possible to provide a drug solution applying device that can withstand long-term use.

[Brief description of drawings]

FIG. 1 is an overall configuration diagram showing a bioadhesive application tool according to an embodiment of the present invention.

FIG. 2 is an overall configuration diagram showing a state in which a drug solution injection inner tube of the device is inserted to a tip of a drug solution injection outer tube.

3 is a sectional view taken along the line AA (straight line portion) of FIG.

FIG. 4 is a sectional view taken along line BB (bent portion) of FIG.

FIG. 5 is an explanatory diagram showing a variable operation of a discharge port of the device.

FIG. 6 is a configuration diagram showing an inner tube base and an inner tube unifying means of the device.

[Explanation of symbols]

10. Inner tube (medical solution injection inner tube) 11. Inner pipe outlet 12. Inner tube chemical passage 2. Inner tube base 30. Outer tube (outer tube for liquid injection) 31. Outer pipe outlet 32. Outer tube chemical passage 4. Outer tube 50. housing 51. Inner pipe base connection 52. Syringe holder 53. Syringe pressing part 54. Grip 6. Coated tube 70. Outer tube 71. Shrink tube 80. Syringe 81. Plunger 82. Barrel tip

Claims (8)

[Claims] 1. In a device for applying a drug solution to a living tissue, a drug solution injection inner tube made of a hard pipe and serving as a drug solution passage, and provided at a proximal end portion of the drug solution injection inner tube and connected to a syringe or the like for containing the drug solution. And a flexible tube having an inner diameter substantially equal to the outer diameter of the drug solution injecting inner tube and having a curved J-shape with a curved tip portion. A medicinal solution injecting outer tube serving as a medicinal solution passage, wherein the medicinal solution injecting inner tube is inserted into a lumen of the medicinal solution injecting outer tube.
A drug solution applicator, wherein a heavy tube is formed, and the shape of the tip of the drug solution injecting outer tube is freely changed in a range from J-shape to linear shape according to the progress of the insertion. 2. The drug solution applying device according to claim 1, wherein an outer tube base serving as a gripping and operating portion is provided at a base end portion of the drug solution injecting outer tube. 3. In a device for mixing two chemical liquids and applying it to a living tissue, two hard pipes are provided in parallel and adjacent to each other, and a first chemical liquid injection inner pipe and a second chemical liquid injection inner pipe, which are passages for the chemical liquids. A pipe, a first inner pipe base and a second inner pipe base which are provided at respective base end portions of the first and second chemical liquid injection inner pipes and are connected to a syringe or the like for storing a chemical liquid respectively; Means for integrating the second chemical liquid injection inner pipe and the first and second inner pipe bases, and an inner diameter substantially equal to the outer diameters of the first and second chemical liquid injection inner pipes, and the tip portion is curved J Two flexible tubes formed to have a shape are provided adjacent to each other in parallel to form a passage for two chemicals together with the first and second inner pipes for injecting a chemical.
A first chemical liquid injection outer pipe, a second chemical liquid injection outer pipe, and means for integrating the first and second chemical liquid injection outer pipes, wherein the first and second chemical liquid injection inner pipes are respectively the first and second From the J shape, the distal ends of the first and second drug solution injecting tubes are integrally synchronized by being inserted into the inner cavity of the second drug solution injecting tube to form double tubes, respectively, and depending on the progress of the insertion. A drug solution applicator characterized in that its shape can be changed freely in a linear range. 4. A connecting portion for connecting and fixing the first and second inner pipe groups as a means for integrating the first and second inner pipes for injecting a chemical solution and the first and second inner pipe groups, A syringe holding part for fixing the syringe attached to the rear end of each inner tube base, a syringe pressing part for integrating the plungers of the respective syringes so that two drug solutions can be simultaneously dispensed, and a device for operating the instrument. 4. The chemical liquid applicator according to claim 3, wherein a housing including a grip portion is provided at the base of the first and second chemical liquid injection inner tubes. 5. As a means for unifying the first and second chemical liquid injection outer pipes, a flexibility in which a tip portion is curved in the same manner as the first and second chemical liquid injection outer pipes and is formed into a J shape. Means for airtightly covering and integrating the first and second chemical liquid injection outer pipes with the coating tube made of a resin in a state of being adjacent to each other in parallel, and / or a base of the first and second chemical liquid injection outer pipes. 5. The drug solution applying device according to claim 3, which is constituted by means for connecting the ends to one outer tube base that can be connected together. 6. An outer cylinder tube for inserting a straight portion (non-curved portion) of the first and second chemical solution injecting outer tubes and a coating tube into an inner cavity, and the first and second chemical solutions on a base of the outer cylinder tube. The drug solution applicator according to any one of claims 3 to 5, further comprising means for integrating the injection outer tube, the covering tube, and the outer tube. 7. The J-shaped curve previously formed on the chemical liquid injection outer pipe or the first and second chemical liquid injection outer pipes has an axis line of a straight line portion of the chemical liquid injection outer pipe and an extension line of a tip discharge port. The angle formed by the is 90 degrees or more and 180 degrees or less.
No. 6 to No. 6 drug application device. 8. The drug solution applicator according to claim 1, wherein the drug solution injection outer tube or the first and second drug solution injection outer tubes is made of a flexible resin having an outer diameter of 1 mm or more and 2 mm or less.