JP2003190122A - Instrument for measuring biological information and sensor for measuring biological information - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biological information measuring instrument in which exact measurements are enabled by simple operation. <P>SOLUTION: The biological information measuring instrument is provided with an exchangeable sensor part 11 having electrode parts 40a and 40b capable of subcutaneous puncture and detection of biological information as electric information caused by the relevant information and an electrode characteristic holding means 22 required for acquiring the biological information on the basis of the electric information detected by the electrode parts 40a and 40b. By setting the sensor part 11 in the instrument body of the instrument, the detected electric information can be processed correspondingly to the characteristics of the sensor part 11 and the exact biological information can be acquired. Therefore, even when the sensor part is exchanged, measurements are enabled by the simple operation without requiring work for inputting information on the characteristics of the electrode parts. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for measuring biological information such as blood glucose level and a sensor for measuring biological information.

[0002]

2. Description of the Related Art In medical examinations and treatments of diabetic patients with insulin, blood is collected and measured for blood glucose level and other components. In particular, when a diabetic patient administers insulin several times a day, the patient himself / herself collects blood from a finger or the like and introduces the blood into a blood glucose measuring device to measure blood component levels such as blood glucose. It is important to understand However, blood sampling and measurement involve physical pain at the time of blood sampling and complicated operations. Therefore, there is a demand for a simple means for measuring blood component values with less pain. On the other hand, in the blood component measuring device, the sensor portion is frequently replaced due to reasons such as deterioration in detection accuracy and sensitivity over time. The sensor usually detects a specific component, but the response level of the sensor is different for each sensor. Therefore, in order to ensure the quantification of the specific component, it is necessary for the processing means of the apparatus body to recognize the information about the characteristics of the sensor and to perform the arithmetic processing and the determination according to the sensor characteristics. Conventionally, the information on the sensor characteristics is stored in a dedicated chip attached to the replacement sensor, and when the sensor is replaced, the user sets the dedicated chip on the measuring device and the information on the sensor characteristics is set on the device body. I had it read. However, if the correction by the dedicated chip is forgotten, correct measurement cannot be performed. Also, the sensor replacement work is complicated.

[0003]

Therefore, according to the present invention,
An object of the present invention is to provide a biological information measuring device capable of performing accurate measurement with a simple operation. Further, it is an object of the present invention to provide a sensor for measuring biological information which enables accurate measurement with a simple operation.

[0004]

In order to solve the above problems, according to the present invention, a biometric information measuring device is capable of being punctured subcutaneously, and the biometric information can be detected as electrical information resulting from the information. Provided is a measuring device including a replaceable sensor unit having a different electrode unit and an electrode characteristic information holding unit necessary for obtaining the biological information based on electrical information detected by the electrode unit. The sensor section of this measuring device includes an electrode section as a detection section and electrode characteristic information necessary to obtain biological information from electrical information detected by the electrode section. Therefore, by setting this sensor unit in the apparatus main body, it is possible to process the electrical information detected according to the characteristics of the sensor unit, and obtain accurate biometric information. Therefore, even if the sensor unit is replaced, the work for inputting the information regarding the characteristics of the electrode unit is not required, and the measurement can be performed by a simple operation.

Further, according to the present invention, the electrode portion is mounted on a substrate having a wiring pattern, and a part of the wiring pattern on the substrate is used as a terminal, and the electrode characteristic information holding means is provided with the wiring pattern. A device that is part of another is provided. In this device, the sensor unit has a substrate having a wiring pattern, and the electrode unit is mounted on the wiring pattern to apply a voltage to the electrode unit or transmit the detected electrical information. The terminals are formed in a wiring pattern. Further, the electrode characteristic information holding means is formed by a wiring pattern provided on the substrate. For this reason, the sensor unit has electrode characteristic information and has a simple structure, which facilitates miniaturization.

Further, when an enzyme layer containing an enzyme active for a specific substance to be measured is provided on the surface of the electrode portion, detection information regarding a predetermined component in the subcutaneous body fluid that reacts with the enzyme is selected. It is a sensor that can be obtained, and can measure a value related to a predetermined component in a living body. Also,
In the sensor unit including the enzyme layer, an electron mediator layer for compensating for a potential difference between the electrode unit and the subcutaneous body fluid is provided, and a substance other than a specific substance is provided between the electrode unit and the subcutaneous body fluid on the outermost surface of the electrode unit. If a cover layer that restricts the movement of the substance is included, it is satisfactorily suppressed that it is blocked by other components or that electrical information related to other components is included, and the detection information regarding a predetermined component is accurate. It becomes a sensor that can detect well.

Further, an exchangeable sensor attached to the biological information measuring device, which is capable of being punctured subcutaneously and which can detect the biological information as electrical information derived from the information, and the electrode. Provided is a sensor having an electrode characteristic information holding unit necessary for obtaining biological information based on electrical information detected by a unit. Since this sensor includes an electrode section for detecting biological information and electrode characteristic information regarding the characteristics of the electrode section, the sensor can read the electrode characteristic information and process the detection information according to the electrode characteristic. By setting it on a measuring device that can be used, accurate biological information can be obtained without performing any special work for processing according to the electrode characteristics.

Further, according to the present invention, the sensor for measuring biological information is composed of a conductive member formed in a shape capable of being punctured under the skin, and the biological information can be detected as electrical information resulting from the information. A sensor having an electrode part and a substrate having a wiring pattern, wherein the electrode part is mounted on the wiring pattern, and the wiring pattern is formed on a terminal of the electrode part. This sensor is configured by mounting an electrode portion, which is formed by subcutaneously puncturing a conductive member, on a wiring pattern capable of forming a terminal. Therefore, the sensor has a simple structure and can be easily miniaturized to the extent that it can be punctured subcutaneously.

[0009]

Embodiments of the present invention will now be described in detail with reference to the drawings. Next, a biological information measuring device including a sensor created based on the above embodiment will be described with reference to FIGS. A biological information measuring device 1 shown in FIG. 1 is a device for measuring a blood glucose level, and includes a main body 2, a sensor mounting portion 10, and a sensor 11 detachably mounted on the sensor mounting portion 10. The sensor mounting portion 10 and the main body portion 2 are connected by a transmission means 3 that enables transmission and reception of energy and signals.

FIG. 2 shows a sensor 11 according to an embodiment of the present invention. The sensor 11 has a plate-shaped base portion 24 made of an insulating material, and has a plurality of electrode portions 40a and 40b that can be punctured subcutaneously on the base portion 24 and an information holding body 22 having electrode characteristic information. There is.

The electrode portions 40a and 40b are formed so that they can be punctured under the skin, and are detecting portions for detecting electrical information of the living body from the subcutaneous body fluid in the state of being punctured under the skin. When the detection unit is composed of electrodes, two electrode units acting as a working electrode and a counter electrode for one type of measurement element,
Or act as working electrode, counter electrode and reference electrode 3
Two electrode parts are provided.

The electrode portions 40a and 40b are formed in a convex shape so that they can be pierced subcutaneously. In order to reduce the pain at the time of puncturing under the skin, the electrode parts 40a, 40
It is preferable that b is sharp and minute. Specifically, for example, the shape may be a cone or a pyramid,
Further, it may be a columnar shape, a prismatic shape or the like having a tapered tip.

The electrode portions 40a and 40b are provided with a conductive member and have various known structures capable of measuring desired biological information by applying a voltage to the subcutaneous body fluid. The conductive member may be composed only of a noble metal material such as platinum, gold or silver, or a film composed of the above noble metal material may be formed on the surface of the member made of a material having good electric conductivity such as copper, aluminum or iron. It may be configured as provided.

The conductive member can be provided, for example, in the form of a film on a convex insulating member that can be pierced subcutaneously. Specifically, it can be formed into a film that covers the entire convex insulating member. Further, in the form in which the convex shape capable of being punctured under the skin is formed by the insulating member, the conductive member may be provided on a plurality of linear lines extending from the tip of the convex portion toward the skirt. In this form, a plurality of electrode portions are formed on one convex portion. Further, the conductive member may be formed into a convex shape that can be directly punctured under the skin.
The conductive member can be formed into a convex shape that can be pierced subcutaneously by various known methods such as etching, molding, and cutting.

The sensor 11 shown in FIG. 2 is a sensor for measuring only one type of measuring element (sugar) and is provided with two electrode portions 40a and 40b. Each electrode portion 40a,
40b, as shown in FIG. 2, is a solid needle-shaped conductive member 3
It is composed of 4. This solid needle-shaped conductive member 34
Is formed by, for example, cutting a rod-shaped noble metal member into a predetermined length, and cutting the tip thereof into a taper shape. This method of forming the conductive member 34 is preferable because it is easy to obtain a sharp tip that can be punctured subcutaneously in a smaller number of steps.

As shown in FIG. 3, the electrode parts 40a and 40b are provided with various coatings, that is, films on the outer surface side of the conductive member 34, so that electrical information relating to predetermined components in subcutaneous body fluids. Only one can be detectably formed. In other words, by providing the outer surface of the conductive member 34 with a layer having various functions, it is possible to form a predetermined biometric information in the detection unit which can be well measured.

In order to detect only electrical information relating to a predetermined component in the subcutaneous body fluid, a selection layer is provided which allows extraction of only the information relating to the predetermined component. The selective layer is an enzyme layer in which enzymes that react only with a predetermined substance are densely arranged,
The limiting permeation membrane layer can be a permeable membrane that transmits a predetermined substance to be measured and does not transmit a substance that affects the potential measurement of the predetermined substance. The enzyme contained in the enzyme layer can be selected from various enzymes capable of specifically reacting with a specific substance in the subcutaneous body fluid. As the enzyme, it is preferable to use a substrate, that is, a substance that reacts with a specific substance in the subcutaneous body fluid accompanied by electron transfer. Alternatively, an enzyme may be used in which a substance produced by the reaction between the enzyme and the substrate causes a charge transfer reaction between the electrode portions 40a and 40b quickly and reliably. For example, when it is desired to measure the value of sugar (glucose), by adding glucose oxidase, it is possible to satisfactorily detect electrical information regarding sugar.

When an enzyme layer is provided, it is preferable to provide an electron mediator layer. The electron mediator layer is a layer for compensating for an excessive potential difference between the electrode part and a specific substance in the subcutaneous body fluid so that the potential can be detected or for improving the detection accuracy. For example, when the enzyme layer consists of glucose oxidase, as an electron mediator,
Various ferrocenes can be used. For example, a ferrocene carboxaldehyde-albumin covalent conjugate is preferable. The electron mediator component may be mixed with the enzyme and contained in the enzyme layer. Alternatively, the enzyme layer and the electron mediator layer may be substantially constituted by one layer by preparing a solution in which an enzyme and an electron mediator component are mixed and applying the solution.

Further, various cover layers can be provided on the outer surfaces of the electrode portions 40a and 40b. The cover layer is a layer that restricts movement of substances other than the specific substance between the electrode portion and the subcutaneous body fluid. That is, the electrode portion 40
It is possible to restrict the attachment or invasion of components other than the specific substance in the subcutaneous body fluid to the a and 40b sides, and
It can be a layer that suppresses the substance constituting b from being eluted into the subcutaneous body fluid. Therefore, the material constituting the cover layer is a component in the subcutaneous body fluid, for example, a material that reduces the adhesion of proteins or the like to the electrode portion, a material that prevents the destruction of the enzyme by the component in the subcutaneous body fluid, or On the other hand, various materials can be selected according to the purpose, such as a material that is rendered harmless. Further, two or more kinds of these may be mixed and used, or a plurality of materials may be provided in a stacked order in a desired order.

In this embodiment, as shown in FIG. 3, the enzyme layer 35 and the electron mediator layer 3 are formed on each conductive member 34.
7, a cover layer 39 is provided. The enzyme layer 35 contains glucose oxidase. The electron mediator layer 37 contains ferrocene carboxaldehyde which is a kind of ferrocene carboxaldehyde-albumin covalent bond. The cover layer 39 is made of 2-methacryloyloxyethyl phosphorylcholine (MPC), which is a polymer material having high biocompatibility and to which components such as proteins in subcutaneous body fluid are hard to adhere.

Further, in the form in which the electrodes 40a, 40b are provided with an enzyme active for a specific substance to be measured, the electrodes 40a, 40b are subjected to electrolytic treatment in a state where at least the enzyme is provided. Is preferred. The electrolytic treatment can be performed by immersing the electrode portions 40a and 40b in an electrolytic solution, typically an electrolytic aqueous solution, and applying a voltage. Also, the electrolytic treatment can be performed by applying a voltage to the electrode portions 40a and 40b in an electrolyte atmosphere filled with an electrolyte component. When the cover layer 39 is provided as in the present embodiment, it is preferable to provide the cover layer 39 after the cover layer 39 is provided because each layer provided to the electrode portions 40a and 40b is stably retained. For example, when glucose oxidase is used as the enzyme contained in the enzyme layer 35, it is preferable that the phosphate buffer solution adjusted to pH 7.4 is electrolyzed as an electrolyte solution. Enzyme layer 3
In the electrode portions 40a and 40b having the electrolytic treatment
The transfer of electrons between the enzyme and the conductive member 34 is smooth, and the measurement sensitivity is improved.

The electrode portions 40a and 40b are fixed to the base portion 24. The electrode parts 40a and 40b may be fixed to the base part 24 by various known forms and are not particularly limited. For example, when the electrode portion is provided with a portion made of an insulating member, the insulating member of the electrode portion and the base portion 24 may be integrally molded to fix the base portion 24 and the electrode portion. In this case, the conductive member 3 is formed on the surface of the insulating member that constitutes the electrode portion.
By directly providing 4 in the form of a film, it becomes a sensor in which the electrode portion is integrated with the base portion. In this mode, by providing the conductive member in a shape extending to above the base portion 24, it is possible to form the terminal of the electrode portion at the same time when the conductive member of the electrode portion is molded. Further, when the information holding body, which will be described in detail later, is composed of wiring, the conductive member of the electrode and the information holding body can be provided in the same step.

When the conductive member 34 is formed of a noble metal material in a convex shape, the transmission portion 30a of the base portion 24,
It can be fixed on 30b by welding, soldering, adhesion with an adhesive, or the like. In this embodiment, as shown in FIG. 3, a convex mounting portion 34 a is formed on the bottom of the conductive member 34. Further, the base portion 24 is provided with a pair of through holes 33a and 33b (so-called through holes). Then, wirings extending from the through holes 33a and 33b to one end of the base portion 24 are provided, and the transmission portion 3 is provided.
0a and 30b are formed. Transmission unit 30a, 30b
Can be a printed wiring made of copper foil provided with the insulating base portion 24 as a substrate. Electrode portion 40a,
In 40b, the mounting portion 34a has a through hole 33 in the base portion 24.
It is fixed by being inserted into a and 33b and being soldered from the back surface side of the information holding body 22. At this time, the transmission units 30a and 30b are capable of applying voltage to the electrode units 40a and 40b and transmitting detection information to the detection information processing means side. The ends of the wirings that form the transmission parts 30a and 30b extending to the ends of the base part 24 are formed in the input / output parts 31a and 31b, and correspond to the "terminals" in this specification.

The sensor 11 having the electrode portion having such an input / output portion can be easily manufactured by fixing the printed board and the conductive member formed by cutting or the like. Further, it is relatively easy to minutely form the printed circuit board and the conductive member, and it is easy to mass-produce a small sensor. In this embodiment,
As shown in FIG. 3, the cover layer 39 includes the electrode parts 40a, 4
0b and the outer surface of the base portion 24 to which the electrode portions 40a and 40b are fixed are covered, and movement of substances between the electrode portions 40a and 40b and subcutaneous body fluid is restricted.

The base portion 24 of this embodiment is provided with an information holding body 22 having electrode characteristic information. In the present specification, "electrode characteristic information" means the difference in detection sensitivity due to the fact that various characteristics differ depending on the material of each electrode portion, the material and thickness of various layers provided on the surface of the electrode portion, the degree of sparseness and denseness, etc. Is information about. That is, the electrode characteristic information is
A numerical value indicating the characteristics of the electrode portion, a correction coefficient, or a predetermined rank can be used. Further, the electrode characteristic information may be a method of processing electrical information detected by the electrode portion (hereinafter, also simply referred to as “detection information”), a method of correcting this processing method, or the like. The electrode characteristic information can be recorded in various formats such as electrical, magnetic and optical. Preferably, when the electrode characteristic information is electrical information, it can be easily integrated with the electrode portion that is a detection portion, and a simple configuration can be easily achieved.

The information holder 22 having the electrode characteristic information is
For example, a bar code, a magnetic recording medium, an electric circuit or the like can be used as the electrode characteristic information holding means of the present invention. The information holder 22 provided with the electrode characteristic information as electrical information is, for example, as shown in FIG. 2, a plurality of wirings 41a to 41c provided on the base portion 24 constituting the wiring board. The wirings 41a to c, 42 can be formed of copper foil and can be provided by a known method such as a corrosion method. That is, the sensor 11 can be configured by a wiring board such as a so-called printed board having the insulating base portion 24 as a substrate.

A plurality of similar wirings 41a, 41b, 41c and a wiring 42 are provided on one half of the one surface of the base portion 24. The plurality of wirings 41a, 41b, 41c form different electrode characteristic information, and are insulated from each other. In the present embodiment, the wirings 41a, 41b, 41c
Can be information indicating the rank of the measurement sensitivity of the sensor. The wiring 42 is connected to any of the wirings 41a to 41c so that the electrode characteristic information formed by the wiring can be output to the measuring device. In the present embodiment, each of the wirings 41a, 41b, 41c and the wiring 42 is provided with input / output sections 43a, 43b, 43c, and 44 arranged in parallel at one end of the base 24, and the wirings 41a to 41c are respectively connected to each other. Input unit 43a-
The position of c serves as electrode characteristic information for the measuring device. In the sensor 11 shown in FIG. 2, the end portion 45a of the wiring 41a opposite to the input / output portion 43a and the end portion 46 of the wiring 42 are provided.
a is connected to a conductive state by a known method such as soldering, and is formed so that the electrode characteristic information formed by the wiring 41a can be output. The wirings 41a, 41b, 41c are
It may have various parts such as an IC, a transistor, and a capacitor, and may have complicated electrode characteristic information.

The sensor mounting portion 10 is a portion for removably fixing the sensor 11 shown in FIG. The sensor mounting portion 10 is not particularly shown, but the wirings 41a to c, 42 are provided.
And an electrode characteristic information input / output unit configured to connect the electrode characteristic information to the main body 2 side, and electrode portions 40a and 40b.
And a detection information input / output unit connected to the main body 2 side. Since such a configuration has various known forms which are electrically connected to the input / output sections 43a to c, 44 of the wirings 41a to c and 42 and the input / output sections 31a and 31b of the transmission sections 30a and 30b, respectively. , Detailed description is omitted.

Further, the sensor mounting portion 10 is provided with a fixing member 16 for stably fixing the sensor 11 in a state of being punctured under the skin. The fixing member 16 is a member that fixes the detection unit 10 to a predetermined part of the skin so that the electrode portions 40a and 40b of the sensor 11 are surely punctured subcutaneously.
In the present embodiment, the fixing member 16 is a suction plate formed of a flexible member, and has a dome shape whose diameter gradually increases from the central portion of the sensor mounting portion 10 toward the side where the electrode portions 40a and 40b project. Is formed in. Fixing member 16
Is pressed against the skin and the air inside the dome shape escapes, so that it is adsorbed to the skin surface. The fixing member may be formed in a disc shape and provided with an adhesive layer that can adhere to the surrounding skin. In this form, the sensor 11 is arranged in the central space of the fixing member so as to be able to puncture the skin.

The main body portion 2 is a portion provided with various means for measuring blood glucose level, and at least the detection information obtained by detecting with the electrode portions 40a and 40b of the sensor 11 is used as the electrode characteristic information of the sensor 11. It is provided with a detection information processing means for processing. The main body 2 of the present embodiment includes a CPU 52 as shown in FIG. 4, and the CPU 52 is a means for processing the detection information. The detection information processing means processes the detection information by combining one or more selected from various known processing methods such as calculation and determination. Then, the detected information processing means obtains a predetermined value and determines whether or not the obtained value satisfies the standard.

As shown in FIG. 4, the CPU 52 is provided with various well-known sensor interfaces 54 through
The sensor 11 is connected so that information can be transmitted and received. CPU5
2 can receive the current value flowing by applying a voltage to the electrode parts 40a and 40b of the sensor 11, and can also receive the electrode characteristic information of the sensor 11.

The CPU 52 is configured to correct the detection information, that is, the current value processing method, according to the electrode characteristic information of the sensor 11. The correction form of the processing of the CPU 52 is not particularly limited. For example, the information holder 2 of the sensor 11
When a ROM or the like is provided in 2 and the correction method corresponding to the measurement sensitivity of the sensor 11 is recorded as the electrode characteristic information, the detection information can be processed based on the electrode characteristic information. Alternatively, a plurality of correction processes may be stored in the CPU 52 in advance, and the predetermined correction process may be selected by the CPU 52 based on the electrode characteristic information of the sensor 11. Alternatively, a separate storage device may be connected to the CPU 52, and the CPU 52 may extract a predetermined correction method in the storage device based on the electrode characteristic information of the sensor 11 and process the detection information.

In this embodiment, the CPU 52 is provided in the main body 2.
A storage device 56 is provided separately from the above. Storage device 56
Is a correction method corresponding to the information regarding the measurement sensitivity of the sensor held by the sensor 11, for example, correction circuits A, B, and C.
It is equipped as ... Further, the main body unit 2 of the present embodiment is provided with an informing unit 60 for informing the measurer of the result processed by the CPU 52 in any form such as voice or display. The notification means 60 is connected to the CPU 52 through the output interface 58. Further, although not particularly shown, the biological information measuring device 1 includes a control unit having various functions such as a power supply unit and a measurement start switch, a power supply unit, and the like.

A method of measuring biological information (blood glucose level) using this biological information measuring device 1 will be described with reference to FIGS. First, the sensor 1 is attached to the sensor mounting portion 10.
Wear 1. When the sensor 11 is connected to the main body 2 side, the CPU 52 receives the electrode characteristic information formed of the wirings 41 a and 42 through the sensor interface 54. The CPU 52, based on the received result,
A predetermined correction circuit stored in the storage device 56 is selected.

Next, the fixing member 16 is pressed against a predetermined part of the skin such as the upper arm or abdomen of the person to be measured to be adsorbed on the skin surface, and the sensor 11 is fixed on the skin. And sensor 1
The first electrode portion 40a, 40b is punctured into the skin and placed subcutaneously. Puncture of the electrode portions 40a and 40b into the skin may be performed by the fixing member 16 or another driving member. Alternatively, a method in which a person manually pushes it to a predetermined portion may be used.

After that, the main body 2 is operated to start the measurement. The CPU 52 applies a predetermined voltage or a voltage with a changed potential difference to the electrode portions 40a and 40b. At this time, a current flows between the electrode portions 40a and 40b depending on the potential difference and the sugar concentration. The CPU 52 uses the electrode section 40.
The information (electrical information) regarding the current is received via the sensor interface 54 through a and 40b (detection unit). Then, this information is processed using the correction circuit that has already been selected based on the electrode characteristic information. CPU 52
The blood glucose level, whether or not the blood glucose level exceeds the standard, or the amount of insulin to be administered is determined by the method.

The processing result by the CPU 52 is transmitted to the notification means 60 through the output interface 58. Then, the notification means 60 notifies the processing result by display, voice, or the like. Based on this notification result, the measurer can grasp the current blood glucose level and determine the amount of insulin to be administered.

In this biological information measuring device 1, the sensor 1
By mounting the sensor 11 on the sensor mounting portion 10 of the apparatus main body, the electrode characteristic information integrated in 1 is provided so that the electrode characteristic information can be transmitted to the CPU 52 which is the detection information processing means. Therefore, it is not necessary for the measurer to perform a work different from the mounting of the sensor 11 for the correction process, and the correction is easy. Further, by using the sensor 11 and performing the measurement in the same manner as in the conventional case, the CPU 52 can surely perform the corrected processing based on the electrode characteristic information corresponding to the sensor 11. Therefore, there is no error in the correction process, and a correct measurement value can always be obtained. Moreover, since a correction chip as in the prior art is not required, the number of parts can be reduced.

Further, the electrode portions 40a, 40b of the sensor 11
Can be formed in a sufficiently small size that it can be punctured subcutaneously. Therefore, subcutaneous puncture can directly measure subcutaneous body fluid in a living body to obtain a value relating to a predetermined component, that is, a blood glucose level. Therefore, it is not necessary to collect blood for measurement, and the mental burden is reduced. Moreover, since blood is not collected, the electrode parts 40a and 40b can be punctured at any part of the living body. Therefore, it is possible to perform measurement on the upper arm or abdomen that is insensitive to pain, and physical pain is reduced.

Further, in such a biological information measuring device 1, since the measurement result can be obtained immediately, the doctor can make a quick diagnosis, and the waiting time for the result of the person to be measured can be shortened, thereby reducing the mental The physical burden is reduced. In addition,
In the biological information measuring device of the present invention, it is possible to simultaneously measure a plurality of measuring elements by increasing the number of protrusions. Therefore, a plurality of measurement items can be measured with a single operation, which is efficient, and the physical and mental distress of the measurement subject can be reduced. In addition, the main body 2 may be provided with a communication unit capable of communicating the processing result obtained by the processing unit to an external device or the like through a telephone line or the like. By providing the communication means, it becomes easy to transmit the measurement result to a remote place and manage the measurement result. For example, a diabetic patient can measure his or her blood glucose level using the device for measuring biological information, and transmit the result to a hospital management center or a doctor, and the measurement result can be transmitted smoothly.

The present invention is not limited to the above embodiment. The biological information measuring sensor is not limited to a sensor that detects a blood glucose level, but may be a sensor that measures various components that have been conventionally measured by collecting blood, urine, and the like. Further, by providing a plurality of sets of electrode portions, the sensor can detect a plurality of types of biological information at one time. The electric information is not limited to the current value, but may be the electrode potential or the potential difference, as a matter of course. Further, in the case of measuring the current value, the current may be detected only by subcutaneously puncturing without applying a voltage between the electrode portions.

In the biological information measuring device, the mounting position of the sensor with respect to the detected information processing means (CPU) is not limited to this embodiment. The sensor attachment part may be fixed to the main body part and integrated, for example, the entire device may be formed in the shape of an armband and attached to the upper arm or the like for measurement. Further, when the sensor is formed of a printed circuit board as in the present embodiment and the electrode characteristic information is constituted by wiring or wiring, the electrode characteristic information holding means of the sensor is incorporated in the substrate of the detection information processing means (CPU). As described above, the sensor may be attached. Further, the information holding bodies are not limited to the form provided on one plane as in the present embodiment, and may be laminated or provided on a curved surface such as a tubular shape.

Further, the step of performing the correction is not limited to the above embodiment. For example, after the measurement is started, the detection information processing unit may receive the detection information, and then the detection information processing unit may receive the electrode characteristic information of the sensor to determine the correction method.

[0044]

According to the present invention, it is possible to provide a biological information measuring device capable of performing accurate measurement by a simple operation. Further, according to the present invention, it is possible to provide a biometric information measurement sensor capable of performing accurate measurement with a simple operation.

[Brief description of drawings]

FIG. 1 is a plan view of a biological information measuring device according to an embodiment of the present invention.

FIG. 2 is a perspective view showing a biological information measuring sensor according to an embodiment of the present invention.

3 is a sectional view of an electrode portion of the sensor of FIG.

FIG. 4 is a block diagram showing a configuration of the measuring apparatus of FIG.

[Explanation of symbols]

1 Biological information measuring device 2 body 3 Transmission means 10 Sensor mounting part 11 sensors 16 Fixed member 22 Information holder 24 base 30a, 30b Transmission unit 31a, 31b input / output section 33a, 33b through holes 34 Conductive member 34a mounting part 35 Enzyme layer 37 Electronic Mediator Layer 39 cover layer 41a, 41b, 41c, 42 wiring 43a, 43b, 43c, 44 Input / output section 45a, 46a ends 52 CPU 54 Sensor interface 56 storage 58 output interface 60 Notification means

Continued front page    (72) Inventor Hiroyuki Kato             Mie Prefectural Tamaki-gun Tamaki Town Dayta 449 3 shares             Company Nishitomo (72) Inventor Kazuhiko Ishihara             3-16-37 Kamimizuhoncho, Kodaira-shi, Tokyo F-term (reference) 4C038 KK10 KL09 KX01 KY04

Claims (6)

[Claims] 1. A biological information measuring device, comprising: an electrode portion that can be punctured subcutaneously and that can detect the biological information as electrical information resulting from the information; and electrical information detected by the electrode portion. An apparatus comprising: a replaceable sensor unit having means for holding electrode characteristic information necessary for obtaining the biometric information based on the above. 2. The electrode part is mounted on a substrate having a wiring pattern, and a part of the wiring pattern on the substrate is used as a terminal, and the electrode characteristic information holding means is another part of the wiring pattern. The device of claim 1, wherein 3. The device according to claim 1, wherein an enzyme layer containing an enzyme active to a specific substance to be measured is provided on the surface of the electrode portion. 4. An electron mediator layer for compensating for a potential difference between the electrode part and the subcutaneous body fluid, wherein the outermost surface of the electrode part contains a substance other than a specific substance between the electrode part and the subcutaneous body fluid. The device of claim 3, comprising a cover layer that limits movement. 5. A replaceable sensor mounted on a biological information measuring device, which is capable of being punctured subcutaneously and capable of detecting the biological information as electrical information resulting from the information, and the electrode. A sensor having electrode characteristic information holding means necessary for obtaining biometric information based on electrical information detected by the unit. 6. A sensor for measuring biological information, comprising an electrically conductive member formed into a shape capable of being punctured under the skin, and an electrode section capable of detecting the biological information as electrical information resulting from the information. A sensor having a substrate having a wiring pattern, wherein the electrode portion is mounted on the wiring pattern, and the wiring pattern is formed on a terminal of the electrode portion.