JP2003171299A - New kothala himbutu extract containing monosaccharide - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an extract of Kothala himbutu and the like, settled the problem of preventing hypoglycemic symptom caused by excessive dose. <P>SOLUTION: This extract of Kothala himbutu and the like is obtained by mixing with 1-10 g preferably 1.5-3.5 g monosaccharide such as fructose or glucose per one dosage so as to perfectly preventing hypoglycemic symptom. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a novel kotalahim extract used for diabetes and diet.

[0002]

2. Description of the Related Art In recent years, many health supplements have been developed and commercialized with the boom of health foods. In particular, since dietary supplements containing α-glucosidase inhibitory ingredients are said to be effective for diet and diabetes, many studies have been conducted. The present inventor obtained a kota lahim extract derived from the vine plant stem of Ceylon, which has a very strong inhibitory activity in the process of searching for an α-glucosidase inhibitory component from a plant.
The extract has been popularly consumed on Ceylon Island for 5000 years due to its effect on diabetes. Miura /
When the α-glucosidase inhibitory activity was measured by the method of Gomei et al., It was at least 10 times more potent than any of the components that had been considered effective so far. Therefore, it could be judged that the ingredient was sufficiently effective. However, due to the extremely strong α-glucosidase inhibitory activity of the extracted components, there is an accident based on hypoglycemic symptoms even if the frequency is 1 in 1000 or 1 in 10,000 drinkers. I don't think so. Actually, when about 3 g was extracted with about 100 ml of boiling water and consumed, a symptom based on hypoglycemia appeared. However, there is no dietary supplement utilizing the α-glucosidase inhibitory action against such hypoglycemia, and there is no known pharmaceutical product utilizing the inhibitory action. Also, hypoglycemia caused by too much insulin is easily improved by taking a few grams of sugar or candy, but in the case of α-glucosidase inhibitory component, sugar or candy is not effective.

[0003]

SUMMARY OF THE INVENTION Therefore, an object of the present invention is to prevent hypoglycemia caused by overdose of the inhibitory ingredient, which may occur during the administration of the α-glucosidase inhibitory ingredient.

[0004]

Means for Solving the Problems As a result of earnest efforts to solve the above problems, monosaccharides such as fructose and glucose are added in an amount of 1 g to 10 g, preferably 1.5 g to 3.
It was found that the use of the Kotarahim extract component mixed with 5 g can completely prevent it, and the present invention has been completed. Specifically, about 10 g of the Kotarahim, when extracted with about 500 ml of boiling water and drinking the extract, symptoms due to hypoglycemia such as dizziness appeared after a short time. However, Kotarahim mixed with the monosaccharide was used. The above symptoms did not appear when the drug was taken. Extraction from the stem of Kotarahim may be carried out by cutting a piece of wood with a size of several centimeters into boiling water for 1 hour or more, or as a powder and then extracting with boiling water. At this time, as a method for mixing the monosaccharides, the monosaccharides may be previously dissolved in an aqueous solution and then boiled for extraction, or a liquid in which the monosaccharides are dissolved may be mixed after the extraction. However, it is more preferable to boil and extract with an aqueous solution in which a monosaccharide is dissolved, because the taste is deeper and the taste is better.

As monosaccharides, glucose (glucose),
Any fructose (fructose), pentose, xylose, etc. that are naturally present and can be absorbed when entering the body to serve as a nutrient source may be used. Particularly, apple juice contains fructose at about 6 to 40%, but it may be mixed with a fruit juice containing a large amount of these monosaccharides at an appropriate concentration. As for the method of mixing, the Kotalahim wood chips or powder may be put into the juice for heating for extraction, or the juice may be mixed after extracting the active ingredient from Kotalahim with an aqueous solution. However, rather, it is preferable to heat and extract in juice as in the case of the above-mentioned monosaccharides, because the taste has a deeper taste and becomes delicious. As the fruit juice, any juice may be used as long as it contains a sufficient amount of monosaccharides (containing 6 to 40%). For example, mandarin orange, yokan, grapefruit, peach, strawberry, melon, plum, banana, grape, cherry and the like. And their mixtures are raised. Further, even vegetables may be ones containing a sufficient amount of monosaccharides (containing 6 to 40%), such as tomato, celery, cabbage, carrot and mixtures thereof. May be

Further, the Kotarahim extract is freeze-dried to give a freeze-dried powder, and the monosaccharide powder or / and the fruit dry powder (including freeze-dried) or / and the vegetable dry powder is added to the freeze-dried powder of Kotalahim. It is preferable to mix (freeze-dried powder) with 0.5 to 30 g / equivalent of 1 g of kotarahim per extract, preferably 1 to 5 g / equivalent of 1 g of kotarahim. Further, the present invention also includes a drink obtained by once producing a freeze-dried powder of Kotarahim and using it to add and mix monosaccharides, fruit juice, vegetables and / or its dry powder (including freeze-dried powder). The form of the mixture is soft drink, juice,
Capsules, sticks, granules, tablets, freeze-dried powders and the like are used, but the method is not particularly limited as long as they are easy to take. Further, the Kotalahim wood pieces are powdered, and 0.5 to 30 g / kotalahim 1 g, preferably 1
It may be taken as capsules, sticks, granules, tablets or the like by mixing -5 g / g of Kotarahim.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION 100 to 1000 ml of 100% apple juice is boiled, and about 10 g of kotarahim is cut into wood pieces or powder or pieces, and the mixture is extracted for several hours or more until it is sufficiently extracted. After cooling, dilute with water or drink as it is, or store it in a container etc. and save it before use. It may be freeze-dried and powdered to be taken. Or boil 100 to 1000 ml of water,
Approximately 10 g of Kotarahim Wood chips or powder or strips are added and extracted for several hours or more until fully extracted. After cooling, dilute with an equal amount of 100% apple juice and then drink as it is, or store it in a container etc. and store it before use. It may be freeze-dried and powdered to be taken. Alternatively, boil 100 to 1000 ml of water and add about 10 g of Kotarahim into wood chips, powder or strips, and extract for several hours or more until fully extracted, then cool down and then add an equal amount of fructose to about 4-6. After diluting with the fruit juice added to the% concentration, it can be drunk as it is, or it can be stored in a container and stored for drinking. It may be freeze-dried and powdered to be taken.

[0008]

EXAMPLES Examples will be shown below, but the present invention is not limited thereto. Example 1 5000 ml of 100% apple juice is boiled, about 100 g of Kotarahim is added to the wood chips, and the extraction is performed for several hours or more until the extraction is sufficiently performed. After cooling, put it in a 500 ml container and save it for drinking. After drinking 50 ml of the Kotarahim extract obtained in this way, after measuring about 1 kg of meal in addition to 3 cups of 500 ml of draft beer, the sugar in urine was always detected as ++. On the other hand, there were no hypoglycemic symptoms such as dizziness. Then, when the Kotarahim extract was not taken at the next meal, the urine sugar became ++ again. As described above, the Kotarahim extract solution to which an appropriate amount of monosaccharide was added showed a feature that it surely prevented urinary sugar and that the effect disappeared immediately when the administration was stopped.

Example 2 Boil 5000 ml of 100% apple juice, add about 100 g of powder of Kotarahim, and extract for several hours or more until it is sufficiently extracted. After cooling, it is packed in 10 500 ml containers and stored for drinking.

Example 3 5000 ml of water was boiled, about 100 g of Kotarahim was added to the wood chips, and several hours or more were extracted until they were sufficiently extracted. After cooling, dilute an equal amount of 100% apple juice into a 500 ml container, store it, and drink at the time of use.

Example 4 500 ml of 100% apple juice was boiled, and about 10 g of Kotarahim was added as wood chips, powder or strips, and the mixture was extracted for several hours or more until it was sufficiently extracted. After cooling, dilute with water or drink as it is, or store it in a container etc. and save it before use. It may be freeze-dried and powdered to be taken. Or water 100 to 1000
Boil ml to bring about 10 g of kotarahim into wood pieces, powder or strips, and extract for several hours or more until fully extracted. After cooling, dilute with an equal amount of 100% apple juice and then drink as it is, or store it in a container etc. and store it before use. It may be freeze-dried and powdered to be taken. Or water 100 to 1000
Boil ml to bring about 10 g of Kotarahim into wood pieces, powder or strips, and extract for several hours or more until fully extracted, then cool down and then add an equal amount of fructose to about 4-6
After diluting with the fruit juice added to the% concentration, it can be drunk as it is, or it can be stored in a container and stored for drinking. It may be freeze-dried and powdered to be taken.

Example 5 500 ml of 100% apple juice is boiled, and about 10 g of Kotarahim is added as wood chips, powder or fine pieces, and the mixture is extracted for several hours or more until it is sufficiently extracted. After cooling, dilute with water or drink as it is, or store it in a container etc. and save it before use. It may be freeze-dried and powdered to be taken. Or water 100 to 1000
Boil ml to bring about 10 g of kotarahim into wood pieces, powder or strips, and extract for several hours or more until fully extracted. After cooling, dilute with an equal amount of 100% apple juice and then drink as it is, or store it in a container etc. and store it before use. It may be freeze-dried and powdered to be taken. Or water 100 to 1000
Boil ml to bring about 10 g of Kotarahim into wood pieces, powder or strips, and extract for several hours or more until fully extracted, then cool down and then add an equal amount of fructose to about 4-6
After diluting with the fruit juice added to the% concentration, it can be drunk as it is, or it can be stored in a container and stored for drinking. It may be freeze-dried and powdered to be taken.

[0013]

The present invention can be a measure for preventing hypoglycemic symptoms that may occur due to excessive intake of α-glucosidase inhibitory components such as kotarahim.

Continued front page    F term (reference) 4B018 LE05 MD28 MD48 MD94 ME03                       MF01                 4C086 AA01 EA01 GA17 MA02 MA04                       NA06 NA09 ZA70 ZC20 ZC35                 4C088 AA02 AB11 AC05 BA09 CA05                       MA04 MA17 MA52 NA06 NA09                       ZA70 ZC20 ZC35

Claims (4)

[Claims] 1. A Kotalahim extract component characterized in that a monosaccharide such as fructose or glucose is mixed in an amount of 1 g to 10 g, preferably 1.5 g to 3.5 g, per dose. 2. The monosaccharide according to claim 1 is a naturally occurring substance such as glucose (fructose), fructose (fructose), pentose, xylose and the like, which can be absorbed when entering the body to serve as a nutrient source. Kotarahim extract to be. 3. A Kotalahim extract characterized by using fruit juice and / or vegetable juice instead of monosaccharides. 4. A Kotarahim extract characterized by extracting an active ingredient from Kotarahim with fruit juice and / or vegetable juice containing 5 to 6% or more of monosaccharides.