JP2003073332A5 - - Google Patents

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JP2003073332A5
JP2003073332A5 JP2002178183A JP2002178183A JP2003073332A5 JP 2003073332 A5 JP2003073332 A5 JP 2003073332A5 JP 2002178183 A JP2002178183 A JP 2002178183A JP 2002178183 A JP2002178183 A JP 2002178183A JP 2003073332 A5 JP2003073332 A5 JP 2003073332A5
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Japan
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group
substituent
general formula
hydroxy
methyl
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JP2002178183A
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Japanese (ja)
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JP2003073332A (en
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Priority to JP2002178183A priority Critical patent/JP2003073332A/en
Priority claimed from JP2002178183A external-priority patent/JP2003073332A/en
Publication of JP2003073332A publication Critical patent/JP2003073332A/en
Publication of JP2003073332A5 publication Critical patent/JP2003073332A5/ja
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Description

２−ヒドロキシカルボン酸エステル類（ＩＩ）としては、例えばマンデル酸メチル、マンデル酸エチル、２−ヒドロキシ−２−（４−メトキシカルボニルフェニル）酢酸エチル、２−ヒドロキシプロピオン酸メチル、２−ヒドロキシプロピオン酸エチル、２−ヒドロキシ−３−フェニルプロピオン酸メチル、２−ヒドロキシブタン酸メチル、２−ヒドロキシブタン酸イソプロピル、２−ヒドロキシブタン酸ｎ−ブチル、２−ヒドロキシ−３−メチルブタン酸メチル、２−ヒドロキシ−３−フェニルブタン酸エチル、２−ヒドロキシ−４−（４−クロロフェニル）ブタン酸エチル、４−アセトキシ−２−ヒドロキシブタン酸メチル、２−ヒドロキシペンタン酸メチル、２−ヒドロキシペンタン酸エチル、２−ヒドロキシ−３−フェニルペンタン酸メチル、２−ヒドロキシ−５−（２−メトキシフェニル）ペンタン酸イソプロピル、４−クロロ−２−ヒドロキシ−５−（２−ナフチル）ヘキサン酸ｔ−ブチル、４−フルオロ−２−ヒドロキシ−４−（４−メチルフェニル）オクタン酸ｎ−ブチル、２−ヒドロキシノナン酸メチル、２−ヒドロキシノナン酸エチル、３−ブロモ−２−ヒドロキシ−５−ニトロノナン酸エチル、２−ヒドロキシ−３−ブテン酸エチル、２−ヒドロキシ−４−ペンチン酸メチルなどが挙げられる。 As 2-hydroxycarboxylic acid esters (II), for example, methyl mandelate, ethyl mandelate, ethyl 2-hydroxy-2- (4-methoxycarbonylphenyl) acetate, methyl 2-hydroxypropionate, 2-hydroxypropionic acid Ethyl, methyl 2-hydroxy-3-phenylpropionate, methyl 2-hydroxybutanoate, isopropyl 2-hydroxybutanoate, n -butyl 2-hydroxybutanoate, methyl 2-hydroxy-3-methylbutanoate, 2-hydroxy- Ethyl 3-phenylbutanoate, ethyl 2-hydroxy-4- (4-chlorophenyl) butanoate, methyl 4-acetoxy-2-hydroxybutanoate, methyl 2-hydroxypentanoate, ethyl 2-hydroxypentanoate, 2-hydroxy -3-phenylpentane Acid methyl, isopropyl 2-hydroxy-5- (2-methoxyphenyl) pentanoate, t -butyl 4-chloro-2-hydroxy-5- (2-naphthyl) hexanoate, 4-fluoro-2-hydroxy-4- (4-Methylphenyl) octanoic acid n -butyl, methyl 2-hydroxynonanoate, ethyl 2-hydroxynonanoate, ethyl 3-bromo-2-hydroxy-5-nitrononanoate, ethyl 2-hydroxy-3-butenoate, Examples thereof include methyl 2-hydroxy-4-pentynoate and the like.

Claims (1)

一般式（ＩＩ）
Figure 2003073332
（式中、Ｒ１およびＲ２はそれぞれ置換基を有していてもよいアルキル基、置換基を有していてもよいアルケニル基、置換基を有していてもよいアルキニル基、置換基を有していてもよいアリール基または置換基を有していてもよいアラルキル基を表す。）
で示される２−ヒドロキシカルボン酸エステル類を、一般式（ＩＩＩ）
Figure 2003073332
（式中、Ｒ３は水素原子、アルコキシル基、アラルキルオキシ基、アシルオキシ基または水酸基を表す。）
で示されるニトロキシラジカル、次亜塩素酸塩、金属臭化物および水の存在下、反応系のｐＨが５〜７の範囲の条件下で酸化することを特徴とする一般式（Ｉ）
Figure 2003073332
（式中、Ｒ１およびＲ２は上記定義のとおりである。）
で示される２−オキソカルボン酸エステル類の製造方法。General formula (II)
Figure 2003073332
 (Wherein, R 1 and R 2 each represent an alkyl group which may have a substituent, an alkenyl group which may have a substituent, an alkynyl group which may have a substituent, a substituent Represents an aryl group which may have or an aralkyl group which may have a substituent.)
And 2-hydroxycarboxylic acid esters represented by the general formula (III)
Figure 2003073332
 (Wherein R 3 represents a hydrogen atom, an alkoxyl group, an aralkyloxy group, an acyloxy group or a hydroxyl group)
In the presence of a nitroxy radical, hypochlorite, metal bromide and water, as shown in the general formula (I), characterized in that the reaction system is oxidized under the condition of pH 5-7.
Figure 2003073332
 (Wherein, R 1 and R 2 are as defined above)
The manufacturing method of 2-oxo carboxylic acid ester shown by these.
JP2002178183A 2001-06-20 2002-06-19 Method for producing 2-oxocarboxylic acid esters Pending JP2003073332A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2002178183A JP2003073332A (en) 2001-06-20 2002-06-19 Method for producing 2-oxocarboxylic acid esters

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001185891 2001-06-20
JP2001-185891 2001-06-20
JP2002178183A JP2003073332A (en) 2001-06-20 2002-06-19 Method for producing 2-oxocarboxylic acid esters

Publications (2)

Publication Number Publication Date
JP2003073332A JP2003073332A (en) 2003-03-12
JP2003073332A5 true JP2003073332A5 (en) 2005-06-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002178183A Pending JP2003073332A (en) 2001-06-20 2002-06-19 Method for producing 2-oxocarboxylic acid esters

Country Status (1)

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JP (1) JP2003073332A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10354259A1 (en) 2003-11-20 2005-06-09 Wacker-Chemie Gmbh Process for the preparation of carbonyl radicals containing organosilicon compounds
CN102212082B (en) * 2010-04-05 2015-03-04 重庆博腾制药科技股份有限公司 Rosuvastatin calcium intermediate and preparation method thereof

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