JP2003012631A - Acrylonitrile compound and agrochemical - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new agrochemical, especially an insecticide. SOLUTION: This acrylonitrile compound is represented by the formula (1) [wherein, A is phenyl which may be substituted with a specific group, naphthyl which may be substituted with a specific group or a specified heterocyclic group which may be substituted with a specific group; B is H, a 1-4C alkyl, a 1-4C haloalkyl group or the like; Q is O-W<1> , S-W<1> or the like; and W<1> is phenyl which may be substituted with a specific group, nahthyl which may be substituted with a specific group or a specified heterocyclic group which may be substituted with a specific group]. The agrochemical comprises the acrylonitrile compound.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a novel acrylonitrile compound and an agricultural chemical containing the compound as an active ingredient. The pesticides in the present invention are insecticides, acaricides, nematicides, herbicides, fungicides, and the like, and especially insecticides, acaricides, and nematicides in the fields of agriculture, horticulture, livestock, and sanitation. .

[0002]

BACKGROUND OF THE INVENTION Acrylonitrile derivatives are disclosed as insecticides in Japanese Patent Application Laid-Open Nos. 53-92769, DE 4330105 and WO 01/32609, and as international patent applications (WO 97/40009, W.
O99 / 44993, WO00 / 17193) have disclosures as pesticides. Also, Japanese Unexamined Patent Publication No.
No. 1452 discloses 2-phenoxy-3 as a herbicide.
-(3-Chlorophenyl) -3-oxopropionitrile is described, and JP-A-60-11401 describes the compound as a fungicide.

[0003]

With the long-term use of insecticides and fungicides, pests have recently acquired resistance,
Control with conventional insecticides and fungicides has become difficult.
Some insecticides are highly toxic, and some are persisting in ecosystems due to persistence. Therefore, the development of new insecticides and fungicides with low toxicity and low residue has always been expected.

[0004]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have demonstrated excellent pest control activity at a low dose and have been used for non-target organisms such as mammals, fish and beneficial insects. As a result of continuing research to develop agrochemicals having almost no adverse effects, the present inventors have found that the following compounds have high safety and excellent pesticidal activity and completed the present invention.

That is, the present invention relates to the following [1] to [7].

[1] Equation (1):

[0007]

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[Wherein A is Y¹May be replaced by
Phenyl, Y¹May be substituted with naphthyl or
Is Y¹A heterocyclic group which may be substituted with
Elementary ring groups are thienyl, furyl, pyrrolyl, oxazolyl
, Isoxazolyl, thiazolyl, isothiazolyl,
Lazolyl, imidazolyl, 1,3,4-oxadiazoli
1,2,4-oxadiazolyl, 1,3,4-thia
Diazolyl, 1,2,4-thiadiazolyl, 1,2,4
-Triazolyl, 1,2,3-thiadiazolyl, 1,
2,3-triazolyl, 1,2,3,4-tetrazoli
, Pyridyl, pyrimidinyl, pyrazinyl, pyridazini
1,3,5-triazinyl, 1,2,4-triazi
Nil, indazolyl, benzoxazolyl, quinolyl,
Isoquinolyl, quinoxalinyl, phthalazinyl, cinno
Linyl or quinazolinyl. ) And B is
H, C₁~ C_FourAlkyl, C_Two~ C₆Alkenyl, C_Two~ C₆
Alkynyl, C ₁~ C_FourHaloalkyl, C_Two~ C₆Haloal
Kenil, C_Two~ C₆Haloalkynyl, C_Two~ C_FourAlkoxy
Alkyl, CH_ThreeSCH_Two, CH_ThreeOC_TwoH_FourOCH_Two, R^a
C substituted with₁~ C_FourAlkyl, R^bC substituted with₁~
C_FourAlkyl, tetrahydropyranyl, (CH_Three)_ThreeS
i, C₁~ C_FourAlkylsulfonyl, halogen or C
₁~ C_FourPhenylsulfo optionally substituted with alkyl
Nil, -SO_TwoCF_Three, C₁~ C_FourMonoalkylaminosul
Honyl, C_Two~ C₈Dialkylaminosulfonyl, phenyl
Luminosulfonyl, C_Two~ C_FiveCyanoalkyl, C_Three~
C₉Alkoxycarbonylalkyl, -C (= O) T¹,
−C (= S) T¹, Alkali metal atom, alkaline earth gold
Genus atom or NHT^FourT^FiveT⁶And Q is -OW¹,
-S-W¹, -NR¹-W^Two, -SO-W^Three, -SO_Two−
W^Three,

[0009]

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[0010] a and, W ¹ and W ² each independently, Y ² phenyl optionally substituted with, Y naphthyl optionally substituted with ^2, Y ² substituted by a heterocyclic group which may be substituted (However, this heterocyclic group is thienyl, furyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, 1,3,4-
Oxadiazolyl, 1,2,4-oxadiazolyl,
1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,4-triazolyl, 1,2,3-thiadiazolyl, 1,2,3-triazolyl, 1,2,3,4
-Tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,3,5-triazinyl, 1,
2,4-triazinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, indazolyl, benzofuranyl, tianaphthenyl, indolyl, benzisoxazolyl, benzoisothiazolyl, benzotriazolyl, benzoxdiadiazol, benzothiadiazolyl,
Quinolyl, isoquinolyl, quinoxalinyl, phthalazinyl, cinnolinyl or quinazolinyl. ) Or

[0011]

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And W^ThreeIs Y^TwoMay be replaced by
Phenyl, Y^TwoOptionally substituted naphthyl, Y^Two
A heterocyclic group which may be substituted
Is thienyl, furyl, pyrrolyl, oxazolyl, iso
Xazolyl, thiazolyl, isothiazolyl, pyrazoly
, Imidazolyl, 1,3,4-oxadiazolyl,
1,2,4-oxadiazolyl, 1,3,4-thiadia
Zolyl, 1,2,4-thiadiazolyl, 1,2,4-to
Liazolyl, 1,2,3-thiadiazolyl, 1,2,3
-Triazolyl, 1,2,3,4-tetrazolyl, pyri
Jill, pyrimidinyl, pyrazinyl, pyridazinyl, 1,
3,5-triazinyl, 1,2,4-triazinyl,
Benzoxazolyl, benzothiazolyl, benzimidazo
Lil, indazolyl, benzofuranyl, thianaphtheni
, Indolyl, benzisoxazolyl, benzisothi
Azolyl, benzotriazolyl, benzooxadiazoli
Benzothiadiazolyl, quinolyl, isoquinolyl,
Quinoxalinyl, phthalazinyl, cinnolinyl or
Nazolinyl. ), C₁~ C_TenAlkyl, C_Two~ C₆
Alkenyl, C_Two~ C₆Alkynyl, C₁~ C₆Haloarchi
Le, C_Two~ C₆Haloalkenyl, C _Two~ C₆Halo alkini
Le, C_Three~ C₆Halocycloalkyl, C₁~ C_ThreeWith alkyl
Optionally substituted C_Three~ C₆Cycloalkyl, C_Two~
C_FourAlkoxyalkyl, C_Two~ C_FourAlkylsulfeni
Rualkyl, Y^TwoOptionally substituted with phenyl C₁~
C_FourAlkyl, Y^TwoPhenoxy C optionally substituted with
₁~ C_FourAlkyl, Y^TwoOptionally substituted with phenyl
Sulfenyl C₁~ C_FourAlkyl, Y^TwoIs replaced by
Phenylsulfinyl C₁~ C_FourAlkyl, Y^Twoso
Optionally substituted phenylsulfonyl C₁~ C_FourAl
Kill, Y^TwoBenzoyl C optionally substituted with₁~ C_Four
Alkyl, Y^TwoPhenoxycal optionally substituted with
Bonil C₁~ C_FourAlkyl, Y^TwoMay be replaced by
Anilino C₁~ C_FourAlkyl, Y^TwoMay be replaced by
Thienyl C₁~ C_FourAlkyl, Y^TwoEven if replaced with
Good Pyridyl C₁~ C_FourAlkyl, tetrahydropyrani
Le, (CH_Three)_ThreeSi, C_Two~ C_FiveCyanoalkyl, C_Three~
C₉Alkoxycarbonylalkyl, C_Three~ C₉Alkyl
Carbonylalkyl or

[0013]

Embedded image

And Z¹Is NR⁶, CHR⁶, O or S, Z^TwoIs NR⁷, CHR⁷, O or S, Z^ThreeIs NR⁸, CHR⁸, O or S, Z^FourIs NR⁹, CHR⁹, O or S, Y¹And Y^TwoIs independently halogen, C₁~ C_TenAl
Kill, C_Two~ C₆Alkenyl, C_Two~ C₆Alkynyl, C₁
~ C₆Haloalkyl, C_Two~ C₆Haloalkenyl, C_Two~ C
₆Haloalkynyl, C_Three~ C₆Halocycloalkyl, C₁~
C_ThreeC optionally substituted with alkyl_Three~ C₆Cycloa
Lucil, C₁~ C₆Alkoxy, C_Two~ C₆Alkenyloxy
Si, C_Two~ C₆Alkynyloxy, C₁~ C_FourHaloalkoki
Si, C_Two~ C₆Haloalkenyloxy, C_Two~ C₆Haloal
Quinyloxy, C_Two~ C_FourAlkoxyalkyl, R^aPut in
Transformed C₁~ C_FourAlkyl, C₁~ C_FourAlkylsulfe
Nil, C₁~ C_FourAlkylsulfinyl, C₁~ C_FourArchi
Rusulfonyl, C_Two~ C₆Alkenylsulfenyl, C_Two
~ C₆Alkenylsulfinyl, C_Two~ C₆Alkenyls
Ruphonyl, C_Two~ C₆Alkynylsulfenyl, C_Two~ C₆
Alkynylsulfinyl, C_Two~ C₆Alkynyl sulfo
Nil, C₁~ C_FourHaloalkylsulfenyl, C ₁~ C_FourC
Loalkylsulfinyl, C₁~ C_FourHaloalkyl sulfo
Nil, C_Two~ C₆Haloalkenylsulfenyl, C_Two~ C₆
Haloalkenylsulfinyl, C_Two~ C₆Haloalkenyl
Sulfonyl, C_Two~ C₆Haloalkynylsulfenyl, C
_Two~ C₆Haloalkynylsulfinyl, C_Two~ C₆Haloal
Quinylsulfonyl, NO_Two, CN, -NU¹U^Two, Feno
Xy, OH, naphthyl, C_Two~ C₇Alkoxycarboni
Le, C_Two~ C_FourAlkylcarbonyl, C_Two~ C_FiveAlkylka
Rubonyloxy, C_Two~ C_FiveHaloalkylcarbonyloxy
X¹A benzoyl optionally substituted with¹Replace with
Optionally substituted phenyl, X¹May be replaced by
Pyridyl, X¹Thienyl optionally substituted with
And -N = CT⁷T⁸1 to 4 arbitrarily selected from
Or an alkylene bonded at an adjacent substitution position
A 5- to 8-membered ring formed by¹Is
C₁~ C₂₀Alkyl, C_Two~ C₆Alkenyl, C_Two~ C₆A
Lucinyl, C₁~ C₆Haloalkyl, C_Two~ C₆Haloarche
Nil, C_Two~ C₆Haloalkynyl, C_Three~ C₆Halocycloa
Lucil, C₁~ C_ThreeC optionally substituted with alkyl_Three
~ C₆Cycloalkyl, C_Two~ C_FourAlkoxyalkyl,
R^aC substituted with₁~ C_FourAlkyl, R^aC substituted with
_Three~ C₆Cycloalkyl, R^aAnd C₁~ C_FourWith alkyl
Substituted cyclopropyl, R^cAnd halogen
Done C_Three~ C_FourCycloalkyl, R^dAnd C₁~ C_FourA
Alkyl substituted cyclopropyl, R^aReplaced by
C_Two~ C_FourAlkenyl, C₁~ C₁₂Alkoxy, C_Two~ C_Five
Alkenyloxy, C_Two~ C_FiveAlkynyloxy, C₁~
C_FourHaloalkoxy, C_Two~ C₆Haloalkenyloxy,
C_Two~ C₆Haloalkynyloxy, C₁~ C_ThreeAlkyl
C which may be replaced_Three~ C₆Cycloalkoxy, benzene
Luoxy, C₁~ C₆Alkylsulfenyl, C_Two~ C₆A
Lucenylsulfenyl, C_Two~ C₆Alkynylsulfeni
Le, C_Two~ C_FiveAlkoxycarbonyl, -NU¹U^Two, Fe
Nilamino, X^TwoA phenyl optionally substituted with^Two
A phenoxy optionally substituted with^TwoReplaced by
Optionally phenylsulfenyl, X^TwoIs replaced by
Naphthyl or X^Two5 which may be substituted by
Or a 6-membered heterocyclic group (however, these heterocyclic groups are
Enyl, furyl, pyrrolyl, oxazolyl, isoxazo
Ril, thiazolyl, isothiazolyl, pyrazolyl, imi
Dazolyl, 1,3,4-oxadiazolyl, 1,2,4
-Oxadiazolyl, 1,3,4-thiadiazolyl,
1,2,4-thiadiazolyl, 1,2,4-triazolyl
1,2,3-thiadiazolyl, 1,2,3-tria
Zolyl, 1,2,3,4-tetrazolyl, pyridyl, pi
Limidinyl, pyrazinyl, pyridazinyl, 1,3,5-
Select from triazinyl and 1,2,4-triazinyl
Devour. ) And T^Four, T^FiveAnd T⁶Are, independently of each other,
H, C₁~ C₆Alkyl, C₁~ C₆Alkenyl, C₁~ C_Three
C optionally substituted with alkyl_Three~ C₆Cycloalkyl
Or benzyl, or T^Four, T^FiveAnd T⁶
Two of them share the nitrogen atom to which each is attached.
Contains oxygen, nitrogen or sulfur atoms
Which form a good 5- to 8-membered ring group;⁷as well as
T⁸Is independently H, phenyl, benzyl or C₁
~ C₆Alkyl or T⁷And T⁸And combine
May form a 5- to 8-membered ring with the carbon atoms
, X¹And X^TwoIs independently halogen, C₁~ C_FourA
Lucil, C₁~ C_FourHaloalkyl, C₁~ C_FourAlkoxy,
C₁~ C_FourHaloalkoxy, C₁~ C_FourAlkylsulfeni
Le, C₁~ C_FourAlkylsulfinyl, C₁~ C_FourAlkyl
Sulfonyl, C_Two~ C_FiveAlkenylsulfenyl, C_Two~
C_FiveAlkenylsulfinyl, C_Two~ C_FiveAlkenyl sulf
Honyl, C₁~ C_FourHaloalkylsulfenyl, C₁~ C_Four
Haloalkylsulfinyl, C₁~ C_FourHaloalkylsul
Honyl, NO_Two, CN, CHO, OH, -NU¹U^Two,
Phenyl, phenoxy and C_Two~ C_FiveAlkoxycarboni
1 to 5 substituents arbitrarily selected from
U¹And U^TwoIs independently H, C₁~ C₆Archi
Le, C_Two~ C_FiveAlkylcarbonyl, C_Two~ C_FiveAlkoxy
Carbonyl, phenyl or benzyl, or U¹When
U^TwoAnd a 5- to 8-membered ring together with the carbon atom to which
R may be formed¹Is H, C₁~ C₆Alkyl, C_Two~
C_FiveAlkylcarbonyl, C_Two~ C_FiveAlkoxycarboni
R, phenyl or benzyl;^TwoAnd R^ThreeIs each
Independently, H, halogen, C₁~ C_FourAlkyl, C₁~ C_Four
Haloalkyl, C₁~ C_FourAlkoxy, C₁~ C_FourHaloal
Coxy, C₁~ C_FourAlkylsulfenyl, C₁~ C_FourAl
Killsulfinyl, C₁~ C_FourAlkylsulfonyl, C _Two
~ C_FiveAlkenylsulfenyl, C_Two~ C_FiveAlkenyls
Rufinil, C_Two~ C_FiveAlkenylsulfonyl, C₁~ C_Four
Haloalkylsulfenyl, C₁~ C_FourHaloalkylsul
Finil, C₁~ C_FourHaloalkylsulfonyl, NO_Two,
CN, CHO, OH, -NU¹U^Two, Phenyl, phenoki
Si and C_Two~ C_FiveArbitrarily from among alkoxycarbonyl
1 to 4 substituents selected,^Four, R^Five,
R⁶, R⁷, R⁸And R⁹Is independently H, C₁~ C₆A
Luquil, X ^TwoOptionally substituted with phenyl or X^Two
A benzyl optionally substituted with^aIs halo
Gen and C₁~ C_FourAt least one selected from alkyl
Optionally substituted phenyl, R^bIs a halogen
And C₁~ C_FourSubstituted with at least one member selected from alkyl
Benzoyl which may be^cAre halogen and
And C₁~ C_FourSubstituted with one or more kinds selected from alkoxy
Phenyl which may be^dIs replaced by halogen
C that may be_Two~ C_FourAlkenyl, n is
It represents the number of tylene groups and is 0, 1 or 2. ]
One or more acrylonitrile compounds
An insecticidal acaricide characterized by comprising:

[2] The formula (1) according to the above [1], wherein
A, B and Q have the same meaning as in claim 1, provided that
A is Y¹Is phenyl optionally substituted with
W¹Is Y^TwoIn the case of phenyl optionally substituted with
B is C₁~ C_FourAlkyl, C_Two~ C₆Alkenyl, C_Two~
C₆Alkynyl, C₁~ C_FourHaloalkyl, C_Two~ C₆Halo
Alkenyl, C_Two~ C₆Haloalkynyl, C_Two~ C _FourArco
Xyalkyl, CH_ThreeSCH_Two, CH_ThreeOC_TwoH_FourOCH_Two,
R^aC substituted with₁~ C_FourAlkyl, R^bC substituted with
₁~ C_FourAlkyl, tetrahydropyranyl, (CH_Three)_ThreeS
i, C₁~ C_FourAlkylsulfonyl, halogen or C
₁~ C_FourPhenylsulfo optionally substituted with alkyl
Nil, -SO_TwoCF_Three, C₁~ C_FourMonoalkylaminosul
Honyl, C_Two~ C₈Dialkylaminosulfonyl, phenyl
Luminosulfonyl, C_Two~ C_FiveCyanoalkyl, C_Three~
C₉Alkoxycarbonylalkyl, -C (= O) T¹,
−C (= S) T¹, Alkali metal atom, alkaline earth gold
Genus atom or NHT^FourT^FiveT⁶It is. The action represented by]
Lilonitrile compounds.

[0016] [3] A is substituted with a naphthyl or Y ¹ may be substituted with Y ¹ Hajime Tamaki (provided that the heterocyclic group are thienyl, furyl, pyrrolyl, oxazolyl, isoxazolyl , Thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, 1,3,4-
Oxadiazolyl, 1,2,4-oxadiazolyl,
1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,4-triazolyl, 1,2,3-thiadiazolyl, 1,2,3-triazolyl, 1,2,3,4
-Tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,3,5-triazinyl, 1,
2,4-triazinyl, indazolyl, benzoxazolyl, quinolyl, isoquinolyl, quinoxalinyl, phthalazinyl, cinnolinyl or quinazolinyl. )
The acrylonitrile compound according to the above [2], which is:

[0017] [4] W ¹ is naphthyl which may be substituted with Y ^2, Y ² Hajime Tamaki which may be substituted with (provided that the heterocyclic group are thienyl, furyl, pyrrolyl, oxazolyl, Isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, 1,3,4-oxadiazolyl, 1,2,4-oxadiazolyl, 1,3
4-thiadiazolyl, 1,2,4-thiadiazolyl,
1,2,4-triazolyl, 1,2,3-thiadiazolyl, 1,2,3-triazolyl, 1,2,3,4-tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,3,5-triazinyl, 1,2,4-triazinyl, benzoxazolyl, benzothiazolyl,
Benzimidazolyl, indazolyl, benzofuranyl,
Tianaphthenyl, indolyl, benzisoxazolyl,
Benzoisothiazolyl, benzotriazolyl, benzooxadiazolyl, benzothiadiazolyl, quinolyl, isoquinolyl, quinoxalinyl, phthalazinyl, cinnolinyl or quinazolinyl. ) Or

[0018]

Embedded image

The acrylonitrile compound according to the above [2], which is

[5] If B is C₁~ C_FourAlkyl, C_Two~ C₆
Alkenyl, C_Two~ C₆Alkynyl, C₁~ C_FourHaloarchi
Le, C_Two~ C₆Haloalkenyl, C_Two~ C₆Halo alkini
Le, C _Two~ C_FourAlkoxyalkyl, CH_ThreeSCH_Two, CH
_ThreeOC_TwoH_FourOCH_Two, R^aC substituted with₁~ C_FourArchi
Le, R^bC substituted with₁~ C_FourAlkyl, tetrahydro
Pyranyl, (CH_Three)_ThreeSi, C₁~ C_FourAlkylsulfoni
Le, halogen or C₁~ C_FourSubstituted with alkyl
Phenylsulfonyl, -SO_TwoCF_Three, C₁~ C_Four
Monoalkylaminosulfonyl, C_Two~ C₈Dialkylur
Minosulfonyl, phenylaminosulfonyl, C_Two~ C_Five
Cyanoalkyl, C_Three~ C₉Alkoxycarbonylalkyl
, -C (= O) T¹, -C (= S) T¹, Alkali metal
Atom, alkaline earth metal atom or NHT^FourT^FiveT⁶In
The acrylonitrile compound according to the above [2].

[6] An agricultural chemical comprising at least one of the acrylonitrile compounds according to [2] to [5] as an active ingredient.

[7] An insecticidal and acaricide comprising at least one of the acrylonitrile compounds as described in [2] to [5] above as an active ingredient.

[0023]

BEST MODE FOR CARRYING OUT THE INVENTION -C of the compound of the present invention of the formula (1)
The (CN) = C (OB)-moiety has two isomers, E-isomer and Z-isomer, when B is other than a hydrogen atom, both of which are included in the present invention.

When B is a hydrogen atom, tautomers exist, which are also included in the present invention.

The heterocyclic group represented by A, W ¹ , W ² , W ³ and T ¹ has the following meaning. That is, thienyl is thiophen-2-yl or thiophen-3-yl, furyl is furan-2-yl or furan-3-yl,
Pyrrolyl is pyrrol-1-yl, pyrrol-2-yl,
Pyrrol-3-yl, oxazolyl is oxazol-2-yl, oxazol-4-yl or oxazol-5-yl; isoxazolyl isoxazol-3-yl, isoxazol-4-yl or isoxazol-5-yl. And thiazolyl is thiazole-
2-yl, thiazol-4-yl or thiazol-5
-Yl and isothiazolyl is isothiazol-3-
Yl, isothiazol-4-yl or isothiazol-5-yl, pyrazolyl is pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl or pyrazol-5-yl; imidazolyl is Imidazol-1-yl, imidazol-2-yl or imidazol-4-yl; 1,3,4-oxadiazolyl is 1,3,4-oxadiazol-2-yl; 1,3,4- Thiadiazolyl is 1,3,4-thiadiazol-2-yl, and 1,2,4-oxadiazolyl is 1,2,4-oxadiazol-3-yl or 1,2,4-oxadiazole-5-yl. Il and 1,
3,4-thiadiazolyl is 1,3,4-thiadiazol-2-yl and 1,2,4-thiadiazolyl is 1,
2,4-thiadiazol-3-yl or 1,2,4-
Thiadiazol-5-yl, 1,2,4-triazolyl is 1,2,4-triazol-1-yl,
2,4-triazol-3-yl or 1,2,4-triazol-4-yl, and 1,2,3-thiadiazolyl is 1,2,3-thiadiazol-4-yl or 1,2,3- Thiadiazol-5-yl,
2,3-triazolyl is 1,2,3-triazole-1
-Yl, 1,2,3-triazol-2-yl or 1,2,3-triazol-4-yl,
3,4-tetrazolyl is 1,2,3,4-tetrazol-1-yl, 1,2,3,4-tetrazol-2-yl or 1,2,3,4-tetrazol-5-yl, Pyridyl is pyridin-2-yl, pyridin-3-yl or pyridin-4-yl; pyrimidinyl is pyrimidin-2-yl, pyrimidin-4-yl or pyrimidin-5-yl; pyrazinyl is pyrazin-2-yl.
Yl; pyridazinyl is pyridazin-3-yl or pyridazin-4-yl; 1,3,5-triazinyl is 1,3,5-triazin-2-yl;
2,4-triazinyl is 1,2,4-triazine-3-
Yl, 1,2,4-triazin-5-yl or 1,
2,4-triazin-6-yl.

Next, A, B, W ¹ , W ² , W ³ , Y ¹ , Y ² ,
R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , X ¹ ,
Preferred ranges of X ² , T ¹ , T ⁴ , T ⁵ , T ⁶ , T ⁷ , T ⁸ , U ¹ and U ² will be described.

Preferred ranges of A are the following groups.

[0028] That is, AI: phenyl optionally substituted with Y ^1, which may be substituted by Y ¹ thienyl, Y ¹
In an optionally substituted furyl, optionally substituted with Y ^1-pyrrolyl, optionally substituted with Y ¹ oxazolyl, optionally substituted with Y ¹ isoxazolyl, Y ¹
In an optionally substituted thiazolyl, optionally substituted with Y ¹ isothiazolyl, pyrazolyl which may be substituted with Y ^1, imidazolyl optionally substituted with Y ^1, optionally substituted with Y ¹ good 1,2,4-triazolyl, optionally substituted with Y ¹ 1,2,3-triazolyl, optionally substituted with Y ¹ 1,2,3-thiadiazolyl, optionally substituted with Y ¹ Good Pyridyl, Y ¹
In an optionally substituted pyrimidinyl, optionally pyridazinyl optionally substituted with good pyrazinyl and Y ¹ may be substituted with Y ^1.

The AII: Y ¹ phenyl optionally substituted by, Y ¹ thiazolyl which may be substituted with, Y ¹ pyrazolyl which may be substituted with, Y ¹ pyridyl and optionally substituted by Y Pyrimidinyl optionally substituted by ¹ .

[0030] AIII: Y ¹ thiazolyl which may be substituted with, Y ¹ is pyrazolyl and even if Y substituted with ¹
Pyridyl optionally substituted with

AIV: Thiazolyl optionally substituted by Y ¹ . AV: pyrazolyl substituted with Y ^1. A
VI: pyridyl optionally substituted by Y ¹ .

Preferred ranges of B are the following groups.

That is, BI: H, C ₁ -C ₄ alkyl, C _2-
C ₆ alkenyl, C ₂ -C ₆ alkynyl, C ₁ -C ₄ haloalkyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ haloalkynyl, C ₂ -C ₄ alkoxyalkyl, CH ₃ OC ₂ H ₄ O
CH ₂ , C ₁ -C ₄ alkylsulfonyl, phenylsulfonyl optionally substituted by one or more selected from halogen and C ₁ -C ₄ alkyl, —SO ₂ CF ₃ , C ₂ -C ₈
Dialkylaminosulfonyl, C ₃ -C ₉ ^{alkoxycarbonylalkyl, -C (= O) T 1} , -C (= S) T 1,
Alkali metal atom, alkaline earth metal atom and NHT
⁴ T ⁵ T ^6.

BII: H, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₂ -C ₄ alkoxyalkyl, CH ₃ OC ₂
H ₄ OCH ₂ , C ₁ -C ₄ alkylsulfonyl, —SO ₂ C
_{F 3, -C (= O)} T 1, -C (= S) T 1, alkali metal atom, an alkaline earth metal atom and NHT ⁴ T ⁵ T ^6.

BIII: H, C ₂ -C ₄ alkoxyalkyl, C ₁ -C ₄ alkylsulfonyl, —SO ₂ CF ₃ , —C
(＝ O) T ¹ , —C (＝ S) T ¹ , alkali metal atom, alkaline earth metal atom and NHT ⁴ T ⁵ T ⁶ .

BIV: C ₂ -C ₄ alkoxyalkyl, C ₁
-C _{4 alkylsulfonyl, -SO 2 CF 3, -C (} =
^{O) T 1, -C (=} S) T 1.

Preferred ranges of W ¹ are the following groups.

[0038] That is, W ¹ I: Y ² phenyl optionally substituted with, naphthyl which may be substituted with Y ^2, which may be substituted by Y ² oxazolyl, optionally substituted with Y ² good thiazolyl, optionally substituted with Y ² isothiazolyl, Y pyrazolyl optionally substituted with ^two, imidazolyl optionally substituted by Y ^2, which may be substituted by Y ² 1, 3,4 -Oxadiazolyl, Y
² may be substituted 1,2,4-oxadiazolyl, optionally substituted with Y ² 1,3,4-thiadiazolyl, optionally substituted with Y ² 1,2,4-thiadiazolyl, 1,2,4- which may be substituted by Y ²
Triazolyl, 1,2,3 optionally substituted by Y ²
- triazolyl, pyridyl optionally substituted by Y ^2, pyrimidinyl optionally substituted by Y ^2, pyrazinyl optionally substituted with Y ^2, may pyridazinyl optionally substituted by Y ^2, by Y ² 1, which may be substituted
3,5 triazinyl, optionally substituted with Y ² 1,2,4-triazinyl, optionally substituted with Y ² benzoxazolyl, optionally substituted by Y ^{2-benzothiazolyl,} Y ² in good benzimidazolyl substituted, it may be substituted by Y ² indazolyl, optionally substituted with Y ² benzofuranyl, optionally substituted with Y ² thianaphthenyl, optionally substituted with Y ² good indolyl, Y may be substituted with ² benzisoxazolyl, Y ² in which may be substituted benzisothiazolyl, Y ² in which it may be substituted benzotriazolyl, substituted by Y ² which may be benzoxadiazolyl, good benzothiadiazolyl may be substituted with Y ^2, which may be substituted by Y ^2-quinolyl,
Y ² isoquinolyl which may be substituted by, may be substituted by Y ² quinoxalinyl, optionally substituted with Y ² phthalazinyl, optionally substituted with Y ² cinnolinyl, optionally substituted with Y ² Quinazolinyl and

[0039]

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[0040]

[0041] W ¹ II: phenyl optionally substituted by Y ^2, naphthyl which may be substituted with Y ^2, which may be substituted by Y ² 1,3,4-thiadiazolyl, optionally substituted with Y ² which may be pyridyl, pyrimidinyl which may be substituted with Y ^2, Y ² in which it may be substituted benzoxazolyl, optionally benzothiazolyl optionally substituted by Y ^2, optionally substituted with Y ² Good Indazolyl, Y ²
In an optionally substituted benzofuranyl, optionally substituted with Y ² thianaphthenyl, indolyl optionally substituted by Y ² may quinolyl optionally substituted by Y ^2, which may be substituted by Y ² good isoquinolyl, optionally substituted with Y ² quinoxalinyl, Y ² may be substituted with phthalazinyl, optionally substituted with Y ² cinnolinyl, Y ² may quinazolinyl and optionally substituted with

[0042]

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[0043]

[0044] W ¹ III: Y ² phenyl optionally substituted with, Y ² naphthyl optionally substituted with, Y ² pyridyl optionally substituted by, quinolyl optionally substituted by Y ² And isoquinolyl optionally substituted with Y ² .

Preferred ranges of W ² are the following groups.

[0046] That is, W ² I: Y ² phenyl optionally substituted with, naphthyl which may be substituted with Y ^2, which may be substituted by Y ² oxazolyl, optionally substituted with Y ² good thiazolyl, optionally substituted with Y ² isothiazolyl, Y pyrazolyl optionally substituted with ^two, imidazolyl optionally substituted by Y ^2, which may be substituted by Y ² 1, 3,4 -Oxadiazolyl, Y
² may be substituted 1,2,4-oxadiazolyl, optionally substituted with Y ² 1,3,4-thiadiazolyl, optionally substituted with Y ² 1,2,4-thiadiazolyl, 1,2,4- which may be substituted by Y ²
Triazolyl, 1,2,3 optionally substituted by Y ²
- triazolyl, pyridyl optionally substituted by Y ^2, pyrimidinyl optionally substituted by Y ^2, pyrazinyl optionally substituted with Y ^2, may pyridazinyl optionally substituted by Y ^2, by Y ² 1, which may be substituted
3,5 triazinyl, optionally substituted with Y ² 1,2,4-triazinyl, optionally substituted with Y ² benzoxazolyl, optionally substituted by Y ^{2-benzothiazolyl,} Y ² in good benzimidazolyl substituted, it may be substituted by Y ² indazolyl, optionally substituted with Y ² benzofuranyl, optionally substituted with Y ² thianaphthenyl, optionally substituted with Y ² good indolyl, Y may be substituted with ² benzisoxazolyl, Y ² in which may be substituted benzisothiazolyl, Y ² in which it may be substituted benzotriazolyl, substituted by Y ² which may be benzoxadiazolyl, good benzothiadiazolyl may be substituted with Y ^2, which may be substituted by Y ^2-quinolyl,
Y ² isoquinolyl which may be substituted by, may be substituted by Y ² quinoxalinyl, optionally substituted with Y ² phthalazinyl, optionally substituted with Y ² cinnolinyl, optionally substituted with Y ² Quinazolinyl and

[0047]

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[0048]

[0049] W ² II: phenyl optionally substituted by Y ^2, naphthyl which may be substituted with Y ^2, which may be substituted by Y ² 1,3,4-thiadiazolyl, optionally substituted with Y ² which may be pyridyl, pyrimidinyl which may be substituted with Y ^2, Y ² in which it may be substituted benzoxazolyl, optionally benzothiazolyl optionally substituted by Y ^2, optionally substituted with Y ² Good Indazolyl, Y ²
In an optionally substituted benzofuranyl, optionally substituted with Y ² thianaphthenyl, indolyl optionally substituted by Y ² may quinolyl optionally substituted by Y ^2, which may be substituted by Y ² good isoquinolyl, optionally substituted with Y ² quinoxalinyl, Y ² may be substituted with phthalazinyl, optionally substituted with Y ² cinnolinyl, Y ² may quinazolinyl and optionally substituted with

[0050]

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[0051]

[0052] W ² III: Y ² phenyl optionally substituted with, Y ² naphthyl optionally substituted with, Y ² pyridyl optionally substituted by, quinolyl optionally substituted by Y ² And isoquinolyl optionally substituted with Y ² .

Preferred ranges of W ³ are the following groups.

[0054] That is, W ³ I: Y ² phenyl optionally substituted with, naphthyl which may be substituted with Y ^2, which may be substituted by Y ² oxazolyl, optionally substituted with Y ² good thiazolyl, optionally substituted with Y ² isothiazolyl, Y pyrazolyl optionally substituted with ^two, imidazolyl optionally substituted by Y ^2, which may be substituted by Y ² 1, 3,4 -Oxadiazolyl, Y
² may be substituted 1,2,4-oxadiazolyl, optionally substituted with Y ² 1,3,4-thiadiazolyl, optionally substituted with Y ² 1,2,4-thiadiazolyl, 1,2,4- which may be substituted by Y ²
Triazolyl, 1,2,3 optionally substituted by Y ²
- triazolyl, pyridyl optionally substituted by Y ^2, pyrimidinyl optionally substituted by Y ^2, pyrazinyl optionally substituted with Y ^2, may pyridazinyl optionally substituted by Y ^2, by Y ² 1, which may be substituted
3,5 triazinyl, optionally substituted with Y ² 1,2,4-triazinyl, optionally substituted with Y ² benzoxazolyl, optionally substituted by Y ^{2-benzothiazolyl,} Y ² in good benzimidazolyl substituted, it may be substituted by Y ² indazolyl, optionally substituted with Y ² benzofuranyl, optionally substituted with Y ² thianaphthenyl, optionally substituted with Y ² good indolyl, Y may be substituted with ² benzisoxazolyl, Y ² in which may be substituted benzisothiazolyl, Y ² in which it may be substituted benzotriazolyl, substituted by Y ² which may be benzoxadiazolyl, good benzothiadiazolyl may be substituted with Y ^2, which may be substituted by Y ^2-quinolyl,
Y ² isoquinolyl which may be substituted by, may be substituted by Y ² quinoxalinyl, optionally substituted with Y ² phthalazinyl, optionally substituted with Y ² cinnolinyl, optionally substituted with Y ² Quinazolinyl,
C ₁ -C ₁₀ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C ₁ -C ₆ haloalkyl, C ₂ -C ₆ haloalkenyl, C ₃ -C ₆ halocycloalkyl, C ₁ -C ₃ optionally substituted by alkyl C ₃ -C ₆ cycloalkyl, Y ²
A phenyl C ₁ -C ₄ alkyl optionally substituted with
Phenoxy C ₁ may be substituted by ² -C ₄ alkyl, benzoyl which may be substituted by Y ² C ₁ -C ₄ alkyl, optionally phenoxycarbonyl optionally substituted by Y ² C ₁ -C ₄ alkyl , anilino which may be substituted by Y ² C ₁ ~C ₄ alkyl, thienyl which may be substituted by Y ² C ₁ ~C ₄ alkyl, pyridyl optionally substituted by Y ² C ₁ ~C ₄ Alkyl, C ₂ -C ₅ cyanoalkyl and

[0055]

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[0056]

[0057] W ³ II: phenyl optionally substituted by Y ^2, naphthyl which may be substituted with Y ^2, which may be substituted by Y ² 1,3,4-thiadiazolyl, optionally substituted with Y ² which may be pyridyl, pyrimidinyl which may be substituted with Y ^2, Y ² in which it may be substituted benzoxazolyl, optionally benzothiazolyl optionally substituted by Y ^2, optionally substituted with Y ² Good Indazolyl, Y ²
In an optionally substituted benzofuranyl, optionally substituted with Y ² thianaphthenyl, indolyl optionally substituted by Y ² may quinolyl optionally substituted by Y ^2, which may be substituted by Y ² good isoquinolyl, Y ² may be substituted with quinoxalinyl, Y ² may be substituted with phthalazinyl, optionally substituted with Y ² cinnolinyl, Y ² may be substituted with quinazolinyl, C ₁ ~ C ₁₀ alkyl, C ₁ -C ₆ haloalkyl, C ₃ ~
C ₆ halocycloalkyl, C ₁ -C ₃ optionally substituted by alkyl C ₃ -C ₆ cycloalkyl, phenyl optionally substituted by Y ² C ₁ -C ₄ alkyl, substituted by Y ² which may be phenoxy C ₁ -C ₄ alkyl, Y ² in which may be substituted anilino C ₁ -C ₄ alkyl, thienyl which may be substituted by Y ² C ₁ ~C ₄ alkyl, Y ²
Pyridyl C ₁ -C ₄ alkyl optionally substituted with

[0058]

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[0059]

[0060] W ³ III: Y ² phenyl optionally substituted with, Y ² naphthyl optionally substituted with, Y ² pyridyl optionally substituted by, quinolyl optionally substituted by Y ² , Y ² is phenyl C ₁ optionally -C ₄ alkyl preferably Y ¹ ranges substituted with good isoquinolyl and Y ² may be substituted in a respective group shown below.

That is, Y ¹ I: halogen, C ₁ -C ₁₀ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C ₁ -C ₆
C ₆ haloalkyl, C ₂ ~C ₆ haloalkenyl, C ₂ ~C ₆
Haloalkynyl, C ₃ -C ₆ halocycloalkyl, C ₁ ~
C ₃ -C ₆ cycloalkyl optionally substituted with C ₃ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₄ haloalkoxy, C ₂ -C ₄ alkoxyalkyl, C ₁ substituted with R ^a
-C ₄ alkyl, C ₁ -C ₄ alkylsulfenyl, C ₁ ~
C ₄ alkylsulfinyl, C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄ haloalkylsulfenyl, C ₁ -C ₄ haloalkylsulfinyl, C ₁ -C _{4 haloalkylsulfonyl, NO 2, CN, C 2} ~C 7 alkoxycarbonyl , C ₂
-C ₄ alkylcarbonyl and C ₂ -C ₅ alkylcarbonyloxy.

Y ¹ II: halogen, C ₁ -C ₁₀ alkyl, C
₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C ₄ alkylsulfenyl, C ₁ -C ₄ alkyl sulfinyl, C ₁ -C ₄ alkylsulfonyl, C ₁ -C ₄
Haloalkylsulfenyl, C ₁ -C ₄ haloalkylsulfinyl, C ₁ -C ₄ haloalkylsulfonyl, NO ₂ and CN.

Y ¹ III: halogen, C ₁ -C ₁₀ alkyl and C ₁ -C ₆ haloalkyl.

[0064] The number of Y ¹ is different depending on the kind of ring Y ¹ replaces, the number of Y ¹ in the case the ring is phenyl Y ¹ is a substituted is an integer from 0 to 5, preferably from 0 4 It is an integer, and more preferably 0, 1, 2, or 3. Y ¹
When the ring to be substituted is naphthyl, the number of Y ¹ is from 0 to 7
And preferably 0. When the ring substituted by Y ¹ is a heterocyclic group, the number of Y ¹ varies depending on the heterocyclic ring, and the heterocyclic ring is 1,3,4-oxadiazolyl,
2,4-oxadiazolyl, 1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,3-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,2
In the case of 3,4-tetrazolyl or 1,2,3,5-tetrazolyl, the number of Y ¹ is 0 or 1. The heterocycle is thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, 1,3,4-triazolyl, 1,2,4
-Triazolyl, 1,2,3-triazolyl, 1,3
In the case of 5-triazinyl, 1,2,4-triazinyl or 1,2,4-triazinyl, the number of Y ¹ is an integer of 0 to 2, preferably 1 or 2. The heterocycle is thienyl, furyl, pyrazolyl, imidazolyl,
In the case of pyrimidinyl, pyrazinyl or pyridazinyl, the number of Y ¹ is an integer of 0 to 3, preferably an integer of 0 to 2, and more preferably 1 or 2. When the heterocycle is pyrrolyl or pyridyl, the number of Y ¹ is an integer of 0 to 4, preferably an integer of 0 to 2, and more preferably 1 or 2.

Preferred ranges of Y ² are the following groups.

That is, Y^TwoI: halogen, C₁~ C_TenArchi
Le, C_Two~ C₆Alkenyl, C_Two~ C₆Alkynyl, C₁~
C₆Haloalkyl, C_Two~ C₆Haloalkenyl, C_Two~ C₆
Haloalkynyl, C_Three~ C₆Halocycloalkyl, C₁~
C_ThreeC optionally substituted with alkyl_Three~ C₆Cycloa
Lucil, C₁~ C₆Alkoxy, C_Two~ C₆Alkenyloxy
Si, C_Two~ C₆Alkynyloxy, C₁~ C_FourHaloalkoki
Si, C_Two~ C₆Haloalkenyloxy, C_Two~ C₆Haloal
Quinyloxy, C_Two~ C_FourAlkoxyalkyl, R^aPut in
Transformed C₁~ C_FourAlkyl, C₁~ C_FourAlkylsulfe
Nil, C₁~ C_FourAlkylsulfinyl, C₁~ C_FourArchi
Rusulfonyl, C_Two~ C₆Alkenylsulfenyl, C_Two
~ C₆Alkenylsulfinyl, C_Two~ C₆Alkenyls
Ruphonyl, C_Two~ C₆Alkynylsulfenyl, C_Two~ C₆
Alkynylsulfinyl, C_Two~ C₆Alkynyl sulfo
Nil, C₁~ C_FourHaloalkylsulfenyl, C₁~ C_FourC
Loalkylsulfinyl, C₁~ C_FourHaloalkyl sulfo
Nil, NO_Two, CN, -NU¹U ^Two, Phenoxy, nafti
Le, C_Two~ C₇Alkoxycarbonyl, C_Two~ C_FourAlkyl
Carbonyl, C_Two~ C_FiveAlkylcarbonyloxy, C_Two
~ C_FiveHaloalkylcarbonyloxy, X¹Replaced by
Optionally benzoyl, X¹May be replaced by
Enil, X¹Pyridyl optionally substituted with¹so
An optionally substituted thienyl.

Y^TwoII: halogen, C₁~ C_TenAlkyl, C
_Two~ C₆Alkenyl, C_Two~ C₆Alkynyl, C₁~ C₆Halo
Alkyl, C₁~ C_ThreeC optionally substituted with alkyl
_Three~ C₆Cycloalkyl, C₁~ C₆Alkoxy, C_Two~ C₆
Alkenyloxy, C_Two~ C ₆Alkynyloxy, C₁~
C_FourHaloalkoxy, C_Two~ C₆Haloalkenyloxy,
C_Two~ C₆Haloalkynyloxy, C₁~ C_FourAlkylsul
Phenyl, C₁~ C_FourAlkylsulfinyl, C₁~ C_FourA
Rukylsulfonyl, C₁~ C_FourHaloalkylsulfeni
Le, C₁~ C_FourHaloalkylsulfinyl, C₁~ C_FourHalo
Alkylsulfonyl, NO_Two, CN, phenoxy, C_Two~
C₇Alkoxycarbonyl, C_Two~ C_FourAlkyl carboni
Le, C_Two~ C_FiveAlkylcarbonyloxy, C_Two~ C_FiveHalo
Alkylcarbonyloxy, X¹May be replaced by
Phenyl, X¹Pyridyl optionally substituted with
X¹Thienyl optionally substituted with

Y ² III: halogen, C ₁ -C ₁₀ alkyl,
C ₁ -C ₆ haloalkyl, C ₃ -C ₆ cycloalkyl optionally substituted with C ₁ -C ₃ alkyl, C ₁ -C ₆ alkoxy, C ₂ -C ₆ alkenyloxy, C ₂ -C ₆ alkynyloxy C ₁ -C ₄ haloalkenyl, C ₂ -C ₆ haloalkenyloxy, C ₂ -C ₆ haloalkynyloxy, C ₁ -C ₄ alkylsulfenyl, C ₁ -C ₄ alkylsulfinyl,
C ₁ -C ₄ alkylsulfonyl, NO _2, CN, phenoxy, C ₂ -C ₇ alkoxycarbonyl, C ₂ -C ₄ alkylcarbonyl, C ₂ -C ₅ alkylcarbonyloxy, C ₂
-C ₅ haloalkylcarbonyl aryloxy and phenyl optionally substituted by X ^1.

[0069] The number of Y ² depending on the type of ring Y ² replaces differ, the number of Y ² in the case the ring is a phenyl which Y ² replaces is an integer from 0 to 5, preferably from 0 4 It is an integer, and more preferably 0, 1, 2, or 3. Y ²
7 0 Number of Y ² in the case but the ring to be replaced naphthyl
And preferably 0. When the ring substituted by Y ² is a heterocyclic group, the number of Y ² differs depending on the heterocyclic ring, and the heterocyclic ring is 1,3,4-oxadiazolyl,
2,4-oxadiazolyl, 1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,3-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,2
In the case of 3,4-tetrazolyl or 1,2,3,5-tetrazolyl, the number of Y ² is 0 or 1. The heterocycle is thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, 1,3,4-triazolyl, 1,2,4
-Triazolyl, 1,2,3-triazolyl, 1,3
In the case of 5-triazinyl, 1,2,4-triazinyl or 1,2,4-triazinyl, the number of Y ² is an integer of 0 to 2, preferably 1 or 2. The heterocycle is thienyl, furyl, pyrazolyl, imidazolyl,
In the case of pyrimidinyl, pyrazinyl or pyridazinyl, the number of Y ² is an integer of 0 to 3, preferably an integer of 0 to 2, and more preferably 1 or 2. When the heterocycle is pyrrolyl or pyridyl, the number of Y ² is an integer of 0 to 4, preferably an integer of 0 to 2, and more preferably 1 or 2.

Preferred ranges of R ¹ are the following groups.

That is, R ¹ I: C ₁ -C ₆ alkyl, C ₂ -C ₅
Alkylcarbonyl, C ₂ -C ₅ alkoxycarbonyl,
Phenyl and benzyl.

Preferred ranges of R ² are the following groups.

That is, R ² I: H, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C 2
₁ -C ₄ haloalkoxy, C ₁ -C _{4 ^{alkylsulfenyl, NO 2, CN, -NU 1}} U 2, phenyl, phenoxy and C ₂ -C ₅ alkoxy optionally selected substituents from the carbonyl (provided that When the number of the substituents is two or more, they may be the same or different from each other.), And the number of the substituents is 1, 2 or 3.

R ² II: H, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, NO ₂ , CN and C ₂ -C
₅ A substituent arbitrarily selected from alkoxycarbonyl (however, when the number of the substituents is two or more, they may be the same or different from each other), and the number of the substituents is 1, 2 or 3 Individual. Preferred ranges of R ³ are the following groups.

That is, R ³ I: H, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C 3
₁ -C ₄ haloalkoxy, C ₁ -C _{4 ^{alkylsulfenyl, NO 2, CN, -NU 1}} U 2, phenyl, phenoxy and C ₂ -C ₅ alkoxy optionally selected substituents from the carbonyl (provided that When the number of the substituents is two or more, they may be the same or different from each other.), And the number of the substituents is 1, 2 or 3.

R ³ II: H, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, NO ₂ , CN and C ₂ -C
₅ A substituent arbitrarily selected from alkoxycarbonyl (however, when the number of the substituents is two or more, they may be the same or different from each other), and the number of the substituents is 1, 2 or 3 Individual.

Preferred ranges of R ⁴ are the following groups.

That is, R ⁴ I: H, C ₁ -C ₆ alkyl and X
Phenyl optionally substituted with ² .

Preferred ranges of R ⁵ are the following groups.

That is, R ⁵ I: H, C ₁ -C ₆ alkyl and X
Phenyl optionally substituted with ² .

Preferred ranges of R ⁶ are the following groups.

That is, R ⁶ I: H, C ₁ -C ₆ alkyl and X
Phenyl optionally substituted with ² .

Preferred ranges of R ⁷ are the following groups.

That is, R ⁷ I: H, C ₁ -C ₆ alkyl and X
Phenyl optionally substituted with ² .

Preferred ranges of R ⁸ are the following groups.

That is, R ⁸ I: H, C ₁ -C ₆ alkyl and X
Phenyl optionally substituted with ² .

Preferred ranges of R ⁹ are the following groups.

That is, R ⁹ I: H, C ₁ -C ₆ alkyl and X
Phenyl optionally substituted with ² .

Preferred ranges of X ¹ are the following groups.

That is, X ¹ I: halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁
-C ₄ haloalkoxy, C ₁ -C ₄ alkylsulfenyl, NO _2, CN ,, phenyl, phenoxy and C ₂ ~
A substituent arbitrarily selected from C ₅ alkoxycarbonyl (however, when the number of the substituents is two or more, they may be the same or different from each other), and the number of the substituents is 1,
2, 3, or 4.

Preferred ranges of X ² are the following groups.

That is, X ² I: halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₁ -C ₄ alkoxy, C ₁
-C ₄ haloalkoxy, C ₁ -C ₄ alkylsulfenyl, NO _2, CN ,, phenyl, phenoxy and C ₂ ~
A substituent arbitrarily selected from C ₅ alkoxycarbonyl (however, when the number of the substituents is two or more, they may be the same or different from each other), and the number of the substituents is 1,
2, 3, or 4.

Preferred ranges of T ¹ are the following groups.

That is, T¹I: C₁~ C₁₈Alkyl, C_Two~ C
₆Alkenyl, C₁~ C_FourHaloalkyl, C_Three~ C₆Haroshi
Chloroalkyl, C₁~ C_ThreeMay be substituted with alkyl
C _Three~ C₆Cycloalkyl, C_Two~ C_FourAlkoxyalkyl
Le, R^aC substituted with₁~ C _FourAlkyl, R^aIs replaced by
C_Three~ C₆Cycloalkyl, R^aC substituted with_Two~ C _Four
Alkenyl, C₁~ C_TenAlkoxy, C_Three~ C_FiveAlkene
Luoxy, C₁~ C_FourHaloalkoxy, C₁~ C_ThreeAlkyl
C optionally substituted with_Three~ C₆Cycloalkoxy,
Ndyloxy, C₁~ C₆Alkylsulfenyl, C_Two~
C₆Alkenylsulfenyl, C_Two~ C₆Alkynylsul
Phenyl, C_Two~ C_FiveAlkoxycarbonyl, -NU
¹U^Two, X^TwoA phenyl optionally substituted with^TwoReplace with
Phenoxy, X^TwoEven if replaced with
Good phenylsulfenyl, X^TwoMay be replaced by
Naphthyl or X^TwoA heterocyclic group which may be substituted with
(However, this heterocyclic group is thienyl, furyl, pyrrolyl,
Oxazolyl, isoxazolyl, thiazolyl, isothia
Zolyl, pyrazolyl, imidazolyl, 1,3,4-oki
Sadiazolyl, 1,2,4-oxadiazolyl, 1,
3,4-thiadiazolyl, 1,2,4-thiadiazol
1,2,4-triazolyl, 1,2,3-thiaasia
Zolyl, 1,2,3-triazolyl, 1,2,3,4-
Tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl,
Pyridazinyl, 1,3,5-triazinyl or 1,
It is selected from 2,4-triazinyl. ).

T¹II: C₁~ C₁₈Alkyl, C_Two~ C₆Al
Kenil, C₁~ C_FourHaloalkyl, C _Two~ C_FourAlkoxya
Lucille, R^aC substituted with₁~ C_FourAlkyl, C₁~ C_Three
C optionally substituted with alkyl_Three~ C₆Cycloalkyl
Le, R^aC substituted with_Three~ C ₆Cycloalkyl, R^aPut in
Transformed C_Two~ C_FourAlkenyl, C₁~ C_TenAlkoxy,
C₁~ C_FourHaloalkoxy, C_Three~ C_FiveAlkenyloxy,
C₁~ C_ThreeC optionally substituted with alkyl_Three~ C₆Shiku
Lower alkoxy, benzyloxy, C₁~ C₆Alkylsul
Phenyl, C_Two~ C₆Alkenylsulfenyl, C_Two~ C₆
Alkynylsulfenyl, C_Two~ C_FiveAlkoxycarboni
Le, X^TwoA phenyl optionally substituted with^TwoReplaced by
Optionally phenoxy, X^TwoMay be replaced by
Phenylsulfenyl, X^TwoMay be replaced by
Naphthyl or X^TwoA heterocyclic group which may be substituted with
(However, this heterocyclic group is thienyl, furyl, oxazolyl
Thiazolyl, pyrazolyl or pyridyl.
Devour. ).

T¹III: C₁~ C₁₇Alkyl, C_Two~ C₆A
Lucenyl, C₁~ C_FourHaloalkyl, R^aC substituted with₁
~ C_FourAlkyl, C₁~ C_ThreeEven if substituted with alkyl
Good C_Three~ C₆Cycloalkyl, R^aC substituted with_Three~ C
₆Cycloalkyl, R^aC substituted with_Two~ C_FourAlkene
Le, C₁~ C₈Alkoxy, C₁~ C_FourHaloalkoxy, C
_Three~ C_FiveAlkenyloxy, C₁~ C_ThreeSubstituted with alkyl
May be C_Three~ C₆Cycloalkoxy, benzyloxy
Si, C₁~ C₆Alkylsulfenyl, C_Two~ C₆Alkene
Rusulfenyl, C_Two~ C₆Alkynylsulfenyl, C
_Two~ C_FiveAlkoxycarbonyl, X^TwoEven if replaced with
Good phenyl, X^TwoPhenoki optionally substituted with
X^TwoPhenylsulfenyl optionally substituted with
Le, naphthyl, X^TwoPyrazolyl optionally substituted with
Or X^TwoPyrazolylpyridyl optionally substituted with
It is.

Preferred ranges of T ⁴ are the following groups.

That is, T ⁴ I: H, C ₁ -C ₄ alkyl, C ₃
-C ₆ or cycloalkyl or benzyl, or two of T ^4, T ⁵ and T ⁶ is an oxygen atom together with the nitrogen atom to which each is attached, also contain a nitrogen atom or a sulfur atom It forms a good 5-, 6- or 7-membered ring group.

Preferred ranges of T ⁵ are the following groups.

That is, T ⁵ I: H, C ₁ -C ₄ alkyl, C ₃
-C ₆ or cycloalkyl or benzyl, or two of T ^4, T ⁵ and T ⁶ is an oxygen atom together with the nitrogen atom to which each is attached, also contain a nitrogen atom or a sulfur atom It forms a good 5-, 6- or 7-membered ring group.

The preferred range of T ⁶ is the following group.

That is, T ⁶ I: H, C ₁ -C ₄ alkyl, C ₃
-C ₆ or cycloalkyl or benzyl, or two of T ^4, T ⁵ and T ⁶ is an oxygen atom together with the nitrogen atom to which each is attached, also contain a nitrogen atom or a sulfur atom good 5-membered ring, which form a 6-membered ring or 7-membered cyclic group, preferable range of T ⁷ is the following groups.

That is, it is T ⁷ I: H, phenyl, benzyl or C ₁ -C ₄ alkyl, or forms a 5- or 6-membered ring with the carbon atom to which T ⁷ and T ⁸ are bonded. .

The preferred range of T ⁸ is the following group.

That is, T ⁸ I: phenyl, benzyl or C
₁ -C ₄ alkyl or is, or T ⁷ and the T ⁸ to form a 5- or 6-membered ring together with the carbon atom bonded.

Preferred ranges of U ¹ are the following groups.

That is, U ¹ I: H, C ₁ -C ₄ alkyl or C ₂ -C ₅ alkylcarbonyl, or a 5-membered or 6-membered ring together with a carbon atom to which U ¹ and U ² are bonded. , Or a seven-membered ring.

Preferred ranges of U ² are the following groups.

That is, U ² I: H, C ₁ -C ₄ alkyl or C ₂ -C ₅ alkylcarbonyl, or a 5-membered or 6-membered ring together with the carbon atom to which U ¹ and U ² are bonded. , Or a seven-membered ring.

Each group in the above-mentioned preferred substituent range can be arbitrarily combined, and the particularly preferred range of the compound of the present invention is described below.

That is, the preferred substituent ranges are AI, BI,
W¹I, W^TwoI, W^ThreeI, Y¹I, Y^TwoI, R ¹I, R^TwoI, R^ThreeI, R
^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T
¹I, T ^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoIn i
Certain compounds of the present invention.

Preferred substituents are AII, BI, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AIII, BI, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
Compounds of the invention which are ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AIV, BI, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AV, BI, W¹I,
W^TwoI, W^ThreeI, Y¹I, Y^TwoI, R¹I, R ^TwoI, R^ThreeI, R^FourI, R
^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T¹I, T
^FourI, T ^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoBook that is i
Invention compound.

Preferred substituents are AVI, BI, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BII, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BII and W ¹ I.
I, W ² II, W ³ II, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R ^{4
I, R 5 I, R 6} I, R 7 I, R 8 I, R 9 I, X 1 I, X 2 I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BII, W¹I
I, W^TwoII, W^ThreeII, Y¹II, Y^TwoII, R ¹I, R^TwoI, R^ThreeI,
R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T
¹I, T ^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoIn i
Certain compounds of the present invention.

Preferred substituent ranges are AI, BII, W¹I
I, W^TwoII, W^ThreeII, Y¹II, Y^TwoII, R ¹I, R^TwoI, R^ThreeI,
R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T
¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoI
A compound of the present invention which is

Preferred ranges of the substituents are AI, BII, W¹I
I, W^TwoII, W^ThreeII, Y¹II, Y^TwoII, R ¹I, R^TwoII, R^ThreeI
I, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred substituents are AI, BIII, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BIII and W ¹ I.
I, W ² II, W ³ II, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R ^{4
I, R 5 I, R 6} I, R 7 I, R 8 I, R 9 I, X 1 I, X 2 I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BIII and W ¹ I.
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BIII and W ¹ I.
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I
A compound of the present invention which is

Preferred ranges of the substituents are AI, BIII and W ¹ I.
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² II, R ³ I
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BIV, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BIV, W ¹ I
I, W ² II, W ³ II, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R ^{4
I, R 5 I, R 6} I, R 7 I, R 8 I, R 9 I, X 1 I, X 2 I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AI, BIV, W¹I
I, W^TwoII, W^ThreeII, Y¹II, Y^TwoII, R ¹I, R^TwoI, R^ThreeI,
R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T
¹I, T ^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoIn i
Certain compounds of the present invention.

Preferred ranges of the substituents are AI, BIV, W¹I
I, W^TwoII, W^ThreeII, Y¹II, Y^TwoII, R ¹I, R^TwoI, R^ThreeI,
R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T
¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoI
A compound of the present invention which is

Preferred ranges of the substituents are AI, BIV, W¹I
I, W^TwoII, W^ThreeII, Y¹II, Y^TwoII, R ¹I, R^TwoII, R^ThreeI
I, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred substituent ranges are AI, BIII and W ¹ I.
II, W ² III, W ³ III, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BIII and W ¹ I.
II, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred substituent ranges are AI, BIII and W ¹ I.
II, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AI, BIII, W¹I
II, W^TwoIII, W^ThreeIII, Y¹II, Y^TwoII, R¹I, R^TwoII, R^Three
II, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AI, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIV, W¹II
I, W^TwoIII, W^ThreeIII, Y¹II, Y^TwoII, R¹I, R^TwoII, R^ThreeI
I, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred substituent ranges are AI, BIII, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹I, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
U^TwoA compound of the present invention which is I.

Preferred substituents are AI, BIII, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AI, BIII and W ¹ I.
II, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
A compound of the present invention which is X ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I, R ³
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I, R ³
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II, R
³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ²
The compound of the present invention which is I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIII, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹III, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred substituent ranges are AI, BIII and W ¹ I.
II, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
^{X 2 I, T 1 III,} T 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I, R ³
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 III, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AI, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II, R
³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ²
The compound of the present invention which is I, T ¹ III, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AII, BII, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AII, BII, W ¹ I
I, W ² II, W ³ II, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R ^{4
I, R 5 I, R 6} I, R 7 I, R 8 I, R 9 I, X 1 I, X 2 I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AII, BII, W ¹ I
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AII, BII, W ¹ I
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I
A compound of the present invention which is

Preferred ranges of the substituents are AII, BII, W ¹ I
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² II, R ³ I
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AII, BIII and W ¹
I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AII, BIII, W¹
II, W^TwoII, W^ThreeII, Y¹I, Y^TwoI, R ¹I, R^TwoI, R^ThreeI, R
^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T
¹I, T ^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoIn i
Certain compounds of the present invention.

Preferred substituents are AII, BIII and W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AII, BIII, W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I
A compound of the present invention which is

The preferred range of the substituent is AII, BIII, W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² II, R ³ I
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AII, BIV, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AII, BIV, W ¹ I
I, W ² II, W ³ II, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R ^{4
I, R 5 I, R 6} I, R 7 I, R 8 I, R 9 I, X 1 I, X 2 I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AII, BIV, W ¹ I
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AII, BIV, W ¹ I
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I
A compound of the present invention which is

Preferred substituent ranges are AII, BIV, W ¹ I
I, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² II, R ³ I
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AII, BIII, W ¹
III, W ² III, W ³ III, Y ¹ I, Y ² I, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred substituents are AII, BIII, W ¹
III, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

The preferred range of the substituent is AII, BIII, W ¹
III, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AII, BIII and W ¹
III, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² II, R
³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ²
The compound of the present invention which is I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AII, BIV, W ¹ I
II, W ² III, W ³ III, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AII, BIV, W ¹ I
II, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred substituent ranges are AII, BIV, W ¹ I
II, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AII, BIV, W¹I
II, W^TwoIII, W^ThreeIII, Y¹II, Y^TwoII, R¹I, R^TwoII, R^Three
II, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AII, BIII and W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I,
R ³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred substituent ranges are AII, BIII, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I,
R ³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AII, BIII, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
A compound of the present invention which is X ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AII, BIV, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹I, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
U^TwoA compound of the present invention which is I.

Preferred substituents are AII, BIV, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred substituents are AII, BIV, W ¹ I
II, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
A compound of the present invention which is X ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AII, BIII, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I,
R ³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 III, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

The preferred range of the substituent is AII, BIII, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
^{X 2 I, T 1 III,} T 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AII, BIV, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹III, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AII, BIV, W ¹ I
II, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
^{X 2 I, T 1 III,} T 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred substituent ranges are AIII, BII, W ¹
I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituent ranges are AIII, BII, W¹
II, W^TwoII, W^ThreeII, Y¹I, Y^TwoI, R ¹I, R^TwoI, R^ThreeI, R
^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T
¹I, T ^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoIn i
Certain compounds of the present invention.

Preferred ranges of the substituents are AIII, BII, W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AIII, BII, W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I
A compound of the present invention which is

Preferred substituent ranges are AIII, BII, W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² II, R ³ I
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AIII, BIII, W
¹ I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIII, W
¹ II, W ² II, W ³ II, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AIII, BIII, W
¹ II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred substituents are AIII, BIII, W
¹ II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AIII, BIII, W
¹II, W^TwoII, W^ThreeII, Y¹II, Y^TwoII, R¹I, R^TwoII, R^ThreeI
I, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AIII, BIV, W ¹
I, W ² I, W ³ I, Y ¹ I, Y ² I, R ¹ I, R ² I, R ³ I, R
⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred substituents are AIII, BIV, W¹
II, W^TwoII, W^ThreeII, Y¹I, Y^TwoI, R ¹I, R^TwoI, R^ThreeI, R
^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X^TwoI, T
¹I, T ^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and U^TwoIn i
Certain compounds of the present invention.

Preferred substituent ranges are AIII, BIV, W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
^A compound of the present invention which is ¹ I, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIV, W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³ I,
R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ² I, T
¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I
A compound of the present invention which is

Preferred ranges of the substituents are AIII, BIV, W ¹
II, W ² II, W ³ II, Y ¹ II, Y ² II, R ¹ I, R ² II, R ³ I
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIII, W
¹ III, W ² III, W ³ III, Y ¹ I, Y ² I, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred substituents are AIII, BIII, W
¹III, W^TwoIII, W^ThreeIII, Y¹II, Y^TwoII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹I, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AIII, BIII, W
¹III, W^TwoIII, W^ThreeIII, Y¹II, Y^TwoII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AIII, BIII, W
¹ III, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
A compound of the present invention which is X ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIV, W ¹
III, W ² III, W ³ III, Y ¹ I, Y ² I, R ¹ I, R ² I, R
³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIV, W ¹
III, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIV and W ¹
III, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² I, R ³
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AIII, BIV, W ¹
III, W ² III, W ³ III, Y ¹ II, Y ² II, R ¹ I, R ² II, R
³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ²
The compound of the present invention which is I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIII, W
¹III, W^TwoIII, W^ThreeIII, Y¹III, Y ^TwoIII, R¹I, R^TwoI,
R^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T¹I, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AIII, BIII, W
¹III, W^TwoIII, W^ThreeIII, Y¹III, Y ^TwoIII, R¹I, R^TwoI,
R^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AIII, BIII, W
¹III, W^TwoIII, W^ThreeIII, Y¹III, Y ^TwoIII, R¹I, R^TwoI
I, R^ThreeII, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X
¹I, X^TwoI, T¹II, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹
I and U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AIII, BIV, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I,
R ³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 I, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

The preferred range of the substituent is AIII, BIV, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I,
R ³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
Compounds of the invention which are ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AIII, BIV, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
A compound of the present invention which is X ² I, T ¹ II, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIII, W
¹III, W^TwoIII, W^ThreeIII, Y¹III, Y ^TwoIII, R¹I, R^TwoI,
R^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T¹III, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AIII, BIII, W
¹III, W^TwoIII, W^ThreeIII, Y¹III, Y ^TwoIII, R¹I, R^TwoI
I, R^ThreeII, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X
¹I, X^TwoI, T¹III, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U
¹I and U^TwoA compound of the present invention which is I.

Preferred ranges of the substituents are AIII, BIV, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I,
R ³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 III, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AIII, BIV, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
^{X 2 I, T 1 III,} T 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

The preferred range of the substituent is AIV, BIII, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I,
R ³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 III, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AIV, BIV, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹III, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred substituents are AIV, BIV, W ¹ I
II, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
^{X 2 I, T 1 III,} T 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

The preferred range of the substituent is AV, BIII, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹III, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred substituent ranges are AV, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I, R ³
I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 III, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred substituent ranges are AV, BIV, W ¹ II
I, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II, R
³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X ²
The compound of the present invention which is I, T ¹ III, T ⁴ I, T ⁵ I, T ⁶ I, T ⁷ I, T ⁸ I, U ¹ I and U ² I.

The preferred range of the substituent is AVI, BIII, W ¹
III, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² I,
R ³ I, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I, X
^{2 I, T 1 III, T} 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Preferred ranges of the substituents are AVI, BIV, W¹I
II, W^TwoIII, W^ThreeIII, Y¹III, Y^TwoIII, R¹I, R^TwoI, R
^ThreeI, R^FourI, R^FiveI, R⁶I, R⁷I, R⁸I, R⁹I, X¹I, X
^TwoI, T ¹III, T^FourI, T^FiveI, T⁶I, T⁷I, T⁸I, U¹I and
And U^TwoA compound of the present invention which is I.

Preferred substituents are AVI, BIV, W ¹ I
II, W ² III, W ³ III, Y ¹ III, Y ² III, R ¹ I, R ² II,
R ³ II, R ⁴ I, R ⁵ I, R ⁶ I, R ⁷ I, R ⁸ I, R ⁹ I, X ¹ I,
^{X 2 I, T 1 III,} T 4 I, T 5 I, T 6 I, T 7 I, T 8 I, a compound of the invention which is U ¹ I and U ² I.

Next, A, B, W ¹ , W ² , W ³ , Y ¹ , Y ² ,
R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ^a ,
^{R b, R c, R d} , X 1, X 2, T 1, T 4, T 5, T 6, T 7,
Examples of each atom and group in the definition of T ⁸ , U ¹ and U ² are shown.

Y ¹ , Y ² , X ¹ , X ² , R ² , R ³ , R ^a ,
Examples of the halogen atom in the definition of R ^b , R ^c or R ^d include a fluorine atom, a chlorine atom, a bromine atom and an iodine atom, and preferably a fluorine atom, a chlorine atom and a bromine atom.

B, W ³ , Y ¹ , Y ² , T ¹ , T ⁴ , T ⁵ ,
T ⁶ , T ⁷ , T ⁸ , X ¹ , X ² , U ¹ , U ² , R ¹ , R ² , R ³ ,
As alkyl in the definition of R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , ^Ra or ^Rb , straight-chain or branched alkyl is methyl, ethyl, n-propyl, isopropyl,
n-butyl, isobutyl, tert-butyl, sec-
Butyl, pentyl-1, pentyl-2, pentyl-3,
2-methylbutyl-1, 2-methylbutyl-2, 2-methylbutyl-3, 3-methylbutyl-1,2,2-dimethylpropyl-1, hexyl-1, hexyl-2, hexyl-3, 1-methylpentyl, 2-methylpentyl,
3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethyl Butyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1
-Methylpropyl, 1-ethyl-2-methylpropyl,
n-heptyl, n-octyl, n-nonyl, n-undecyl, n-dodecyl, n-tridecyl, n-tetradecyl, n-pentadecyl, n-hexadecyl, n-heptadecyl, n-octadecyl, n-nonadecyl, n- Icosyl and the like are mentioned, and each is selected in the range of the designated number of carbon atoms.

B, W ³ , Y ¹ , Y ² , T ¹ , T ⁴ , T ⁵ , T ⁶
Or alkenyl in the definition of R ^d includes ethenyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl,
-Butenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl,
3-pentenyl, 4-pentenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-
Butenyl, 1-methyl-3-butenyl, 2-methyl-3
-Butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-propenyl, 1-hexenyl,
2-hexenyl, 3-hexenyl, 4-hexenyl, 5
-Hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4
-Methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-
4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl,
1,1-dimethyl-2-butenyl, 1,1-dimethyl-
3-butenyl, 1,2-dimethyl-2-butenyl, 1,
2-dimethyl-3-butenyl, 1,3-dimethyl-2-
Butenyl, 1,3-dimethyl-3-butenyl, 2,3-
Dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-2-butenyl, 1-ethyl-
2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,
2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl, and the like can be mentioned, and each is selected from the specified carbon number range.

In the definition of B, W ³ , Y ¹ , Y ² or T ¹ , alkynyl is ethynyl, 1-propynyl, 2-propynyl, linear or branched alkynyl.
-Butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl,
3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-
Butynyl, hexynyl, 1-methyl-3-pentynyl,
1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-4-
Pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl and the like can be mentioned, and each is selected from the range of the specified number of carbon atoms.

B, W ³ , Y ¹ , Y ² , T ¹ , X ¹ , X ² , R ²
Or haloalkyl in the definition of R ³ includes, as a straight-chain or branched haloalkyl, fluoromethyl, chloromethyl, bromomethyl, fluoroethyl, chloroethyl, bromoethyl, fluoro-n-propyl, chloro-n-propyl, difluoromethyl, chlorodifluoro Methyl, trifluoromethyl, dichloromethyl, trichloromethyl, difluoroethyl, trifluoroethyl,
Trichloroethyl, chlorodifluoromethyl, bromodifluoromethyl, trifluorochloroethyl, hexafluoro-n-propyl, chlorobutyl, fluorobutyl,
Chloro-n-pentyl, fluoro-n-pentyl, chloro-n-hexyl, fluoro-n-hexyl and the like can be mentioned, and each is selected from the specified carbon number range.

W ³ , Y ¹ , Y ² , T ¹ , T ⁴ , T ⁵ or T ⁶
In the definition of, C ₃ -C ₆ cycloalkyl optionally substituted with C ₁ -C ₃ alkyl includes cyclopropyl, 1-methylcyclopropyl, 2,2,3,3-tetramethylcyclopropyl, Cyclobutyl, 1-ethylcyclobutyl, 1-n-butylcyclobutyl, cyclopentyl, 1-methylcyclopentyl, cyclohexyl,
Examples thereof include 1-methylcyclohexyl and 4-methylcyclohexyl.

In the definition of B, Y ¹ , Y ² or T ¹ ,
Examples of the C ₁ -C ₄ alkyl substituted with ^Ra include benzyl, 2-chlorobenzyl, 3-bromobenzyl, 4-chlorobenzyl, 4-methylbenzyl, 4-tert-butylbenzyl, 1-phenylethyl, -(3-chlorophenyl) ethyl, 2-phenylethyl, 1-methyl-1-phenylethyl, 1- (4-chlorophenyl)-
1-methylethyl, 1- (3-chlorophenyl) -1-
Methylethyl, 1-phenylpropyl, 2-phenylpropyl, 3-phenylpropyl, 1-phenylbutyl,
2-phenylbutyl, 3-phenylbutyl, 4-phenylbutyl, 1-methyl-1-phenylpropyl, 1-methyl-2-phenylpropyl, 1-methyl-3-phenylpropyl, 2-methyl-2-phenylpropyl , 2-
(4-chlorophenyl) -2-methyl-propyl, 2-
Methyl-2- (3-methylphenyl) propyl and the like.

C ₃ substituted by R ^a in the definition of T ¹
-C ₆ cycloalkyl includes 1-phenylcyclopropyl, 1- (3-chlorophenyl) cyclopropyl,
1- (4-chlorophenyl) cyclopropyl, 1- (4
-Bromophenyl) cyclopropyl, 1- (4-fluorophenyl) cyclopropyl, 1- (4-ethylphenyl) cyclopropyl, 1- (4-propylphenyl) cyclopropyl, 2-phenylcyclopropyl, 1-phenylcyclo Butyl, 2-phenylcyclobutyl, 1-phenylcyclopentyl, 1- (4-chlorophenyl) cyclopentyl, 2-phenylcyclopentyl, 3-phenylcyclopentyl, 1-phenylcyclohexyl,
1- (3-fluorophenyl) cyclohexyl, 1-
(4-chlorophenyl) cyclohexyl, 1- (4-tert-butylphenyl) cyclohexyl, 2-phenylcyclohexyl, 3-phenylcyclohexyl,
-Phenylcyclohexyl and the like.

In the definition of T ¹ , cyclopropyl substituted with R ^a and C ₁ -C ₄ alkyl includes 2,2-
Dimethyl-1-phenylcyclopropyl, 1- (4-chlorophenyl) -2,2-dimethylcyclopropyl,
2,2-dimethyl-3-phenylcyclopropyl, 3-
(3-chlorophenyl) -2,2-dimethylcyclopropyl, (4-chlorophenyl) -2,2-dimethyl-3
-Phenylcyclopropyl, (4-bromophenyl)-
2,2-dimethyl-3-phenylcyclopropyl, 2,
2-dimethyl-3- (4-methylphenyl) cyclopropyl, (4-tert-butylphenyl) -2,2-
Dimethyl-3-phenylcyclopropyl and the like.

In the definition of T ¹ , R ³ and C ₃ -C ₄ cycloalkyl substituted with halogen include 2,2-
Dichloro-1-phenylcyclopropyl, 2,2-dichloro-1- (3-chlorophenyl) cyclopropyl,
2,2-dichloro-1- (4-methoxyphenyl) cyclopropyl, 2,2-dichloro-1- (4-ethoxyphenyl) cyclopropyl, 2,2-dichloro-1- (4
-I-propyloxyphenyl) cyclopropyl, 2,
2-dichloro-1- (4-t-butylphenyl) cyclopropyl, 2,2-dichloro-1- (4-methoxyphenyl) -3-phenylcyclopropyl, 1- (4-ethoxyphenyl) -2,2 , 3,3, -tetrafluorobutyl and the like.

In the definition of T ¹ , cyclopropyl substituted by R ^d and C ₁ -C ₄ alkyl includes 2,2-
Dimethyl-3- (2,2-dimethylethenyl) cyclopropyl, 3- (2,2-dibromoethenyl) -2,2-
Dimethylcyclopropyl, 3- (2,2-dichloroethenyl) -2,2-dimethylcyclopropyl, 3- (2
2-chlorotrifluoroethenyl) -2,2-dimethylcyclopropyl and the like.

C ₃ -C ₆ cycloalkoxy which may be substituted with C ₁ -C ₃ alkyl in the definition of T ¹ includes:
Cyclopropoxy, cyclobutoxy, cyclopentoxy, cyclohexyloxy, 1-methylcyclopropoxy and the like.

In the definition of T ¹ , C ₂ substituted by R ^a
-C ₄ alkenyl as 1-phenylethenyl,
2-phenylethenyl, 2- (2-chlorophenyl) ethenyl, 2- (3-chlorophenyl) ethenyl, 2-
(4-chlorophenyl) ethenyl, 2- (4-methylphenyl) ethenyl, 2- (2,6-difluorophenyl) ethenyl, 2- (2,5-dimethylphenyl) ethenyl, 1-methyl-2-phenylethenyl , 2-phenyl-1-propenyl, 2- (4-bromophenyl) -1
-Propenyl, 2- (2,4,6-trimethylphenyl) -1-propenyl and the like.

As the alkoxy in the definition of Y ¹ , Y ² , T ¹ , X ¹ , X ² , R ² , R ³ or R ^C , methoxy, ethoxy, n-
Propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, n-pentyloxy, 1-methylbutyloxy, 2-methylbutyloxy, 3-methylbutyloxy, 1,1-dimethylpropoxy, , 2-dimethylpropoxy, 2,2-
Dimethylpropoxy, 1-ethylpropyloxy, n-
Hexyloxy, 1-methylpentyloxy, 2-methylpentyloxy, 3-methylpentyloxy, 4-methylpentyloxy, 1,1-dimethylbutyloxy,
1,2-dimethylbutyloxy, 1,3-dimethylbutyloxy, 2,2-dimethylbutyloxy, 2,3-dimethylbutyloxy, 3,3-dimethylbutyloxy,
1-ethylbutyloxy, 2-ethylbutyloxy,
1,1,2-trimethylpropyloxy, 1,2,2-
Trimethylpropyloxy, 1-ethyl-1-methylpropyloxy, 1-ethyl-2-methylpropyloxy, n-heptyloxy, n-octyloxy, n-nonyloxy, n-decyloxy and the like. It is selected from a range of carbon numbers.

C in the definition of W ³ , Y ¹ , Y ² or T ¹
₃ The halocycloalkyl of -C _6, fluorocyclopropyl, difluorocyclopropyl, chlorocyclopropyl, dichloro-cyclopropyl, 1-methyl-2,2
-Dichlorocyclopropyl, chlorocyclobutyl, dichlorocyclobutyl, chlorocyclopentyl, dichlorocyclopentyl, chlorocyclohexyl, dichlorocyclohexyl, tetrafluorocyclobutyl and the like.

Y ¹ , Y ² , T ¹ , X ¹ , X ² , R ² or R ³
In the definition of -NU ¹ U ² , methylamino, ethylamino, n-propylamino, isopropylamino,
n-butylamino, isobutylamino, sec-butylamino, tert-butylamino, n-pentylamino, 1-methylbutylamino, 2-methylbutylamino, 3-methylbutylamino, 1,1-dimethylpropylamino, , 2-dimethylpropylamino, 2,2-
Dimethylpropylamino, 1-ethylpropylamino,
n-hexylamino, 1-methylpentylamino, 2-
Methylpentylamino, 3-methylpentylamino, 4
-Methylpentylamino, 1,1-dimethylbutylamino, 1,2-dimethylbutylamino, 1,3-dimethylbutylamino, 2,2-dimethylbutylamino, 2,3
-Dimethylbutylamino, 3,3-dimethylbutylamino, 1-ethylbutylamino, 2-ethylbutylamino, 1,1,2-trimethylpropylamino, 1,2,2
2-trimethylpropylamino, 1-ethyl-1-methylpropylamino, 1-ethyl-2-methylpropylamino, dimethylamino, diethylamino, di-n-propylamino, diisopropylamino, di-n-butylamino, di- sec-butylamino, diisobutylamino, di-n-pentylamino, di-n-hexylamino, methylethylamino, methylpropylamino, methylisopropylamino, methylbutylamino, methyl-
sec-butylamino, methylisobutylamino, methyl-tert-butylamino, methylpentylamino,
Methylhexylamino, ethylpropylamino, ethylisopropylamino, ethylbutylamino, ethyl-s
ec-butylamino, ethylisobutylamino, ethylpentylamino, ethylhexylamino, phenylamino, benzylamino, N-methylacetamide, N-ethylacetamide, N-phenylacetamide, N-acetylacetamide and the like. It is selected in the range of carbon number.

Y ¹ , Y ² , T ¹ , X ¹ , X ² , U ¹ , U ² ,
Alkoxycarbonyl in the definition of R ¹ , R ² or R ³ includes methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, iso-propoxycarbonyl, n-butoxycarbonyl, sec-butoxycarbonyl, iso-butoxycarbonyl, tert-
Butoxycarbonyl, n-pentyloxycarbonyl,
n-hexyloxycarbonyl and the like, and each is selected within the range of the specified number of carbon atoms.

Y ¹ , Y ² , T ¹ , X ¹ , X ² , R ² or R ³
Examples of haloalkoxy in the definition of include straight-chain or branched-chain haloalkoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorodifluoromethoxy, bromodifluoromethoxy, dichlorofluoromethoxy, chloromethoxy, dichloromethoxy, Trichloromethoxy, bromomethoxy, fluoroethoxy, chloroethoxy, bromoethoxy, difluoroethoxy, trifluoroethoxy, tetrafluoroethoxy, pentafluoroethoxy, trichloroethoxy, trifluorochloroethoxy, fluoropropoxy, chloropropoxy, bromopropoxy, fluorobutoxy, Chlorobutoxy, fluoro-iso-propoxy and chloro-iso-propoxy and the like.

Y ¹ , Y ² , T ¹ , X ¹ , X ² , R ² or R ³
Examples of alkylsulfenyl in the definition of are methylthio, ethylthio, n-propylthio, iso-propylthio, n-butylthio, iso-butylthio, sec.
-Butylthio and tert-butylthio.

The C ₁ -C ₄ alkylsulfinyl in the definition of Y ¹ , Y ² , X ¹ , X ² , R ² or R ³ includes methylsulfinyl, ethylsulfinyl, n-propylsulfinyl, iso-propylsulfinyl, n -Butylsulfinyl, iso-butylsulfinyl, sec
-Butylsulfinyl and tert-butylsulfinyl.

C ₁ -C ₄ alkylsulfonyl in the definition of B, Y ¹ , Y ² , X ¹ , X ² , R ² or R ³ includes methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, iso-propylsulfonyl , N-butylsulfonyl, iso-butylsulfonyl, sec-butylsulfonyl and tert-butylsulfonyl.

In the definition of B, W ³ , Y ¹ , Y ² or T ¹ , C ₂ -C ₄ alkoxyalkyl includes C ₁ -C ₃ alkoxy-methyl, C ₁ -C ₂ alkoxy-ethyl,
Methoxyethoxymethyl and methoxypropyl.

The alkylcarbonyl in the definition of Y ¹ , Y ² , U ¹ , U ² or R ¹ includes acetyl, propionyl, butanoyl, iso-butanoyl and the like.

Examples of the C ₂ -C ₅ haloalkylcarbonyloxy in the definition of Y ¹ or Y ² include chloroacetyloxy, trifluoroacetyloxy, 3,3,3-trifluoropropionyloxy, pentafluoropropionyloxy and the like. Can be

The naphthyl in the definition of A, W ¹ , W ² , W ³ , Y ¹ , Y ² or T ¹ includes 1-naphthyl and 2-naphthyl.

[0251] Y ¹ or Y as good pyridyl optionally substituted by X ¹ in ² definitions, may be substituted by X ¹ 2-pyridyl, optionally substituted by X ¹ 3
- pyridyl or X ¹ may be substituted 4-pyridyl and the like, preferably may be substituted with may 2-pyridyl or X ¹ to be replaced by X ¹ 3-
Pyridyl, and more preferably 2-pyridyl which may be substituted by X ¹ .

[0252] As the thienyl which may be substituted by X ¹ in the definition of Y ¹ or Y ^2, may 3-thienyl which may be substituted with may 2-thienyl and X ^1, which may be substituted by X ¹ can give.

-N = CT ⁷ in the definition of Y ¹ or Y ²
T ⁸ means alkylideneamino, benzylideneamino, arylideneamino or cycloalkylideneamino, methylideneamino, ethylideneamino, propylideneamino, isopropylideneamino, 4-methyl-2-pentylideneamino, cyclopentylideneamino, cyclohexylidene And denamino.

As the C ₁ -C ₄ monoalkylaminosulfonyl in the definition of B, methylaminosulfonyl,
Examples include ethylaminosulfonyl, n-propylaminosulfonyl, isopropylaminosulfonyl, and n-butylaminosulfonyl.

C ₂ -C ₈ dialkylaminosulfonyl in the definition of B includes dimethylaminosulfonyl, diethylaminosulfonyl, di-n-propylaminosulfonyl, diisopropylaminosulfonyl and di-n-
Butylaminosulfonyl and the like.

In the definition of B, C ₁ -C substituted with R ^b
Examples of C ₄ alkyl include phenacyl, 2-fluorophenacyl, 3-chlorophenacyl, 4-bromophenacyl, 2-methylphenacyl, 3-ethylphenacyl,
-I-propylphenacyl, 4-t-butylphenacyl and the like.

In the definition of B, halogen or C ₁
-C ₄ as good phenylsulfonyl optionally substituted by alkyl, 2-fluoro-phenylsulfonyl, 4-
Fluorophenylsulfonyl, 2-chlorophenylsulfonyl, 4-chlorophenylsulfonyl, 4-bromophenylsulfonyl, 2,5-dichlorophenylsulfonyl, pentafluorophenylsulfonyl, 4-methylphenylsulfonyl, 2-methylphenylsulfonyl,
-T-butylphenylsulfonyl, 2,5-dimethylphenylsulfonyl, 2,4-dimethylphenylsulfonyl, 2,4,6-trimethylphenylsulfonyl, 2,
4,6-tri-i-propylphenylsulfonyl and the like.

The C ₂ -C ₅ cyanoalkyl in the definition of B or W ³ includes cyanomethyl, 2-cyanoethyl, 3-cyanopropyl, 1-cyano-1-methylethyl and the like.

The C ₃ -C ₉ alkoxycarbonylalkyl in the definition of B or W ³ includes methoxycarbonylmethyl, ethoxycarbonylmethyl, n-propoxycarbonylmethyl, i-propoxycarbonylmethyl as straight-chain or branched alkoxycarbonylalkyl. N-butoxycarbonylmethyl, i-butoxycarbonylmethyl, t-butoxycarbonylmethyl, n-hexyloxycarbonylmethyl, n-heptyloxycarbonylmethyl, 1-methoxycarbonylethyl, 1-
Ethoxycarbonylethyl, 1-n-butoxyethyl,
2-methoxycarbonylethyl, 2-ethoxycarbonylethyl, 1-methoxycarbonylpropyl, 3-ethoxycarbonylpropyl, 4-methoxycarbonylbutyl, 6-ethoxycarbonylhexyl, 1-methoxycarbonyl-1-methylethyl, 1-iso- And propoxycarbonyl-1-methylethyl, 1-ethoxycarbonyl-2-methylpropyl and the like.

As the alkali metal in the definition of B,
Lithium, sodium and potassium.

Examples of the alkaline earth metal in the definition of B include magnesium, calcium, strontium and barium, and preferably magnesium, calcium and barium.

As ammonium represented by NHT ⁴ T ⁵ T ⁶ in the definition of B, ammonium , Monomethylammonium, dimethylammonium, trimethylammonium, diethylammonium, triethylammonium, diisopropylammonium, diisopropylethylammonium, hexylmethylammonium, cyclopropylmethylammonium, cyclohexylmethylammonium, allylmethylammonium, benzylmethylammonium or 4-methylcyclohexyl A 5-membered heterocyclic ring which may be ethylammonium or two of T ⁴ , T ⁵ and T ⁶ may contain an oxygen atom, a nitrogen atom or a sulfur atom together with the nitrogen atom to which each is attached, 6-membered ring, 7-membered ring or 8-membered ring ammonium and the like.

T ⁴ , T ^{5 in} the definition of T ⁴ , T ⁵ or T ⁶
Heterocyclic 5-, 6-, 7- or 8-membered heterocyclic ring which may contain an oxygen atom, a nitrogen atom or a sulfur atom together with a nitrogen atom to which two of ⁵ and T ⁶ are respectively bonded As ammonium, pyrrolidine, pyrazolidine, imidazolidine, oxazolidine, isoxazolidine,
Thiazolidine, piperidine, piperazine, morpholine,
Thiamorpholine, hexamethyleneimine and heptamethyleneimine are exemplified.

In the definition of Y ¹ , Y ² , X ¹ , X ² , R ² or R ³ , haloalkylsulfenyl is a straight-chain or branched-chain haloalkylthio such as fluoromethylthio, chlorodifluoromethylthio, and bromodifluoromethylthio. , Trifluoromethylthio, trichloromethylthio, 2,2,2-trifluoroethylthio, 1,
1,2,2-tetrafluoroethylthio, fluoroethylthio, pentafluoroethylthio and fluoro-is
o-propylthio and the like.

As the haloalkylsulfinyl in the definition of Y ¹ , Y ² , X ¹ , X ² , R ² or R ³ , fluoromethylsulfinyl, chlorodifluoromethylsulfinyl, bromodifluoro as a linear or branched haloalkylsulfinyl Methylsulfinyl, trifluoromethylsulfinyl, trichloromethylsulfinyl, 2,2,2-trifluoroethylsulfinyl,
1,1,2,2-tetrafluoroethylsulfinyl,
Fluoroethylsulfinyl, pentafluoroethylsulfinyl, fluoro-iso-propylsulfinyl and the like.

As the haloalkylsulfonyl in the definition of Y ¹ , Y ² , X ¹ , X ² , R ² or R ³ , fluoromethylsulfonyl, chlorodifluoromethylsulfonyl, linear or branched haloalkylsulfonyl,
Bromodifluoromethylsulfonyl, trifluoromethylsulfonyl, trichloromethylsulfonyl, 2,2,2
2-trifluoroethylsulfonyl, 1,1,2,2-
Examples include tetrafluoroethylsulfonyl, fluoroethylsulfonyl, pentafluoroethylsulfonyl, fluoro-iso-propylsulfonyl and the like.

[0267] ^{B, W 3, Y 1,} Y as the ² or haloalkenyl in the definition of T ^1, 2-chloroethenyl as linear or branched haloalkenyl of C ₂ -C _4, 2-bromoethenyl, 2,2 -Dichloroethenyl and the like.

Alkenyloxy in the definition of Y ¹ , Y ² or T ¹ includes allyloxy, 2-propenyloxy and 2-alkenyloxy as linear or branched alkenyloxy.
Butenyloxy, 2-methyl-2-propenyloxy and the like.

As the haloalkenyloxy in the definition of Y ¹ , Y ² or T ¹ , 3-chloro-2-propenyloxy, 3,3-dichloro-2-propenyloxy, as a linear or branched haloalkenyloxy, 4-chloro-2-butenyloxy, 4,4-dichloro-3-butenyloxy, 4,4-difluoro-3-butenyloxy and the like.

Y ¹ , Y ² , T ¹ , X ¹ , X ² , R ² or R ³
Examples of the alkenylsulfenyl in the definition of the above include allylsulfenyl, 2-propenylsulfenyl, 2-butenylsphenyl, 2-methyl-2-propenylsulfenyl and the like as linear or branched alkenylsulfenyl.

Alkenylsulfinyl in the definition of Y ¹ , Y ² , X ¹ , X ² , R ² or R ³ includes allylsulfinyl, 2-propenylsulfinyl, and 2-butenylsulfinyl as linear or branched alkenylsulfinyl. Nyl, 2-methyl-2-propenylsulfinyl and the like.

Alkenylsulfonyl in the definition of Y ¹ , Y ² , X ¹ , X ² , R ² or R ³ includes allylsulfonyl as linear or branched alkenylsulfonyl,
2-propenylsulfonyl, 2-butenylsulfonyl, 2
-Methyl-2-propenylsulfonyl and the like.

The haloalkenylsulfenyl in the definition of Y ¹ or Y ² includes 3-chloro-2-propenylsulfenyl, 4-chloro-2-butenylsulfenyl as straight-chain or branched haloalkenylsulfenyl, 3,3-dichloro-2-propenylsulfenyl,
4,4-dichloro-3-butenylsulfenyl, 4,4
-Difluoro-3-butenylsulfenyl and the like.

As the haloalkenylsulfinyl in the definition of Y ¹ or Y ² , 3-chloro-2-propenylsulfinyl, 3,3-dichloro-2-propenylsulfinyl, 4-chloro as a straight-chain or branched haloalkenylsulfinyl -2-butenylsulfinyl,
4,4-dichloro-3-butenylsulfinyl, 4,4
-Difluoro-3-butenylsulfinyl and the like.

As the haloalkenylsulfonyl in the definition of Y ¹ or Y ² , 3-chloro-2-propenylsulfonyl, 3,3-dichloro-2-propenylsulfonyl, 4-chloro -2-butenylsulfonyl, 4,4-dichloro-3-butenylsulfonyl, 4,4-difluoro-3-butenylsulfonyl and the like.

The haloalkynyl in the definition of B, W ³ , Y ¹ , Y ² or T ¹ includes chloroethynyl, bromoethynyl, iodoethynyl, 3-chloro-1-propynyl, 3-bromo-1-butynyl and the like. can give.

Alkynyloxy in the definition of Y ¹ , Y ² or T ¹ includes 2-propynyloxy, 2-butynyloxy, 1-methyl-2-propynyloxy and the like.

Examples of haloalkynyloxy in the definition of Y ¹ , Y ² or T ¹ include 3-chloro-2-propynyloxy, 3-bromo-2-propynyloxy, 3-iodo-2-propynyloxy and the like. .

The alkynylsulfenyl in the definition of Y ¹ , Y ² or T ¹ includes 2-propynylsulfenyl, 2-butynylsulfenyl, 1-methyl-2-propynylsulfenyl and the like.

Alkynylsulfinyl in the definition of Y ¹ or Y ² includes 2-propynylsulfinyl, 2
-Butynylsulfinyl, 1-methyl-2-propynylsulfinyl and the like.

The alkynylsulfonyl in the definition of Y ¹ or Y ² includes 2-propynylsulfonyl, 2-butynylsulfonyl, 1-methyl-2-propynylsulfonyl and the like.

Examples of haloalkynylsulfenyl in the definition of Y ¹ or Y ² include 3-chloro-2-propynylsulfenyl, 3-bromo-2-propynylsulfenyl, 3-iodo-2-propynylsulfenyl and the like. Can be

Examples of haloalkynylsulfinyl in the definition of Y ¹ or Y ² include 3-chloro-2-propynylsulfinyl, 3-bromo-2-propynylsulfinyl, 3-iodo-2-propynylsulfinyl and the like.

The haloalkynylsulfonyl in the definition of Y ¹ or Y ² includes 3-chloro-2-propynylsulfonyl, 3-bromo-2-propynylsulfonyl,
-Iodo-2-propynylsulfonyl and the like.

Examples of the alkylcarbonyloxy in the definition of Y ¹ or Y ² include acetoxy, propanoyloxy, butanoyloxy, isopropylcarbonyloxy and the like, and each is selected within the range of the specified number of carbon atoms.

The benzoyl optionally substituted by X ¹ in the definition of Y ¹ or Y ² includes benzoyl, 2-
Chlorobenzoyl, 3-chlorobenzoyl, 4-chlorobenzoyl, 4-bromobenzoyl, 4-fluorobenzoyl, 3-methylbenzoyl, 4-methylbenzoyl, 4-tert-butylbenzoyl, 3,4-dichlorobenzoyl and the like. .

The compound of the present invention is useful for so-called agricultural pests that infest agricultural and horticultural crops and trees, so-called livestock pests that infest livestock and poultry, so-called sanitary pests that have various adverse effects on human living environments such as houses, and warehouses. So-called stored pests that injure stored grains and the like, and any pests such as mites, nematodes, molluscs, and crustaceans that occur and injure in similar situations can be effectively controlled at low concentrations.

Insects which can be controlled using the compounds of the present invention;
As mites, nematodes, molluscs and crustaceans, there are Nikameiga (Chilo suppressalis) and Kobunomeiga (Cnaphalo)
crocis medinalis), Necroga melanalis (Nerenga aenesc)
ens), Ichimon disseri (Parnara guttata), Japanese moth (Plutella xylostella), and armyworm (Mamestra brassi)
cae), cabbage butterfly (Pieris rapae crucivora),
Kabulayaga (Agrotis segetum), Spodoptera litura (Spo
dptera litura), Syringe armyworm (Spodptera e)
xigua), Helicoverpa armigera, Adlerophytes sp., Homona magnanima, Carposina nipo
nensis), Nasihime Shingui (Grapholita molesta),
Apple linden (Adoxophyes orana fasciat)
a), Kinmonhosoga (Phyllonorycter ringoniell)
a), cotton ball worm (Helicoverpa zea), tobacco bad worm (Heliothis virescens), European corn borer (Ostrinia nubialis), fall army worm (Spodoptera frugiperda), codling moth (Cydia pomonella), and Hyphant (Hyphant)
ria cunea) and other lepidopteran pests
hotettix cincticeps), brown planthopper (Nilaparvata)
lugens), peach aphid (Myzus persicae), cotton aphid (Aphis gossypii), whitefly (Trialeurodes vaporariorum), silverleaf whitefly (Bemisia tabaci), pear lice (Psylla pyr)
icola), Stephantis pyriodes, Unaspis yanonensis, Pseudococcus comstocki, Ceroplastes rubens, Drosicha corpulenta
ha mista), Hemiptera pests such as sea turtles (Eurydema rugosam) and bed bugs (Cimex lectularis), and Henosepilachna vigintioctopunctat
a), Dung beetle (Anomala cuprea), Bean beetle (Popilla japonica), Rice weevil (Lissorho)
ptrus oryzophilus) and Sphenophrus (Sphenophrus)
venatus vestitus) and the weevil weevils (Cylas for
micarius), cricket beetle (Aulacophora femoralis),
Beetle flea beetle (Phyllotreta striolata), Colorado beetle (Leptinotarsa decemlineata), Beetle beetle (Anoplophora malasiaca), Blue-faced beak beetle (Paederus fusceps), Pine beetle (Monochamus shanatus)
otus tamsuyensis), European agaricus (Europea)
domina), corn root worm (Diabrotica spp.),
Coleopteran pests such as Sitophilus oryzae, Sitophilus granarius and Tribolium castaneum, Liriomyza trifoli, and Denfly plaque
tura), Hessian flies (Mayetiola destructor), Sea flies (Dacus (Zengodacus) cucurbitae), Mediterranean flies (Ceratitis capitata), House flies (Musc)
a domestica), sand flies (Stomoxys calcitrans), sheep flies (Melophagus orinus), flies (Hypoderm lineatum), and bullflies (Hypoderma bori)
s), sheep flies (Oestrus ovis), tsetse flies (G
olossina palpais), Prosciulium ye
zoensis), Cattle flies (Tabanus trigonus), Drosophila (Telmatoscopus albipunctatus), Tokunagakuro-nukaka (Leptoconopsnipponensis)
lex pipiens pallens, Aedes aegypti (Aedes aegyp)
ti), dipteran pests such as Aedes albopictus and Anopheles culicifacies, hornets (Athalis rosae ruficornis), pine trees (Neodiprion sertifer), chestnuts (Ape)
thymust kuri), Guntai ants, Black ants (Campon)
otus japonicus, wasp (Vespa mandarin)
a), Hymenoptera pests such as bulldog ant, fire ant and pharaoh ant, Thrips palmi, Thrips tabac
i) Citrus thrips (Frankliniella occiden)
talis, Thrips thrips (Frankliniella inton)
sa) and Thrips palmi (Scirtothrips dorsa)
lis) and other pteratoid pests, black cockroaches (Periplaneta f
uliginosa), cockroach (Periplaneta japonic)
a) and reticulate pests such as German cockroaches (Blattella germanica), oaks (Gryllotalpa africana), emma crickets (Teleogryllus emma), and locusts (Loc)
usta migratoria), Red locust (Oxya yezoensis)
Orthodox pests, such as the locust and the locust grasshopper (Schistocerca gregaria), the termite (Coptotermes formosan)
us), termite pests such as the termite (Leucotermes speratus) and the termite (Odontotermes formosanus), cat flea (Ctenocephalides felis),
Isopteran pests such as human flea (Pulex irritans) and keops rat flea (Xenopsylla cheopis);
opinus suis, bullfinch lice (Linognathus vitul)
i) and louse pests, such as Solenopotescapillatus, and Ctenolepisma villos
a) and other pests, such as Lilaccelis bo
Strychophilus) and other insects;
nonychus citri, apple spider mite (Panonychus ulm)
i), spider mites such as Tetranychus urticae and Tetranychus kanzawai, red mite (Aculops pelekassi), red mite (Epitrimerus pyri), tulip rust mite (Aceria
tulipae) and Acaphylla thea
e) and other mites, such as Pplyphagota
Dust mites such as rsonemus latus and Cyclamen mite, Tyrophagus putrescetia
e) and acarid mites such as Rhizoglyphusrobini, and honey bee mites (Varroa jacobsoni)
And house dust mites such as Boophilus microplu
s) and Haemaphysalis longicorni
s), ticks such as sheep ticks, narcissuses such as Sarcaptes scabiei, scabine, scabine (Sclope)
ndra subspinipes japonica), gezi (Thereuronema hi)
lippods such as lgendorfi, Oxidus gracil
is), diplopods such as fusidae, sweet potato nematode (Meloidogyne incognita), red root knot nematode (Meloidogyne hapla), northern root nematode (Pratylenchus penetraus), walnut root nematode (Pratylenchus vulnus), and potato moss Nematodes such as nematodes (Bursaphelenchus xylophilus),
Black mussel (Pomacea canaliculta), slug (Incilaria pilineata), African snail (Achatin)
a fulica), Usukawamaimai (Acusta despectasiebo)
ldiana) and Misujimaimai (Euhadra peliomphala)
And molluscs, such as the beetle (Armadilliduim vulg
ara latreille) and other crustaceans.

The plant disease to be controlled by the compound of the present invention includes rice blast (Pyricularia oryza).
e), sesame leaf blight (Cochliobolus miyabeanus), sheath blight (Rhizoctonia solani), wheat powdery mildew (Erysip)
he graminis, f. sp. hordei, f. sp. tritici), leaf spot (Pyrenophora graminea), reticulum (Pyrenophora te)
res), Fusarium head blight (Gibberella zeae), Rust (Puccin)
ia striiformis, P. graminis, P. recondita, P. hord
ei), snow rot (Typhula sp., Micronectriella nivai)
s), naked smut (Ustilago tritici, U. nuda), eye spot (Pseudocercosporella herpotrichoides), scald (Rhynchosporium secalis), leaf blight (Septoria t)
ritici), Fusarium wilt (Leptosphaeria nodorum), Citrus black spot (Diaporthe citri), Scab (Elsinoe f
awcetti), fruit rot (Penicillium digitatum, P. i)
talicum), Monilia disease of apple (Sclerotinia mal)
i), rot (Valsa mali), powdery mildew (Podosphae)
ra leucotricha), spot leaf rot (Alternaria mali),
Scab (Venturia inaequalis), Pear scab (Ventu
ria nashicola), black spot (Alternaria Kikuchiana),
Red scab (Gymnosporangium haraeanum), peach scab (Sclerotinia cinerea), scab (Cladosporium carp)
ophilum), Phomopsis sp.,
Grape downy mildew (Plasmopara viticola), black rot (E
lsinoe ampelina), late rot (Glomerella cingulat)
a), powdery mildew (Uncinula necator), rust (Phako)
psora ampelopsidis, oyster anthracnose (Gloeosporium k)
aki), deciduous disease (Cercospora kaki, Mycosphaerella naw)
ae), Downy mildew of cucumber (Pseudoperenospora cubensi)
s), anthracnose (Colletotrichum lagenarium), powdery mildew (Sphaerotheca fuliginea), vine blight (Mycosphaer)
ella melonis), Tomato plague (Phytophthora infesta)
ns), ring spot (Alternaria solani), leaf mold (Clado)
sporium fulvam, eggplant brown spot (Phomopsis vexan)
s), powdery mildew (Erysiphe cichoracoarum), black spot of cruciferous vegetables (Alternaria japonica), white spot (C)
erocosporella brassicae), rust on leeks (Puccinia)
allii), soybean purpura (Cercospora kikuchii), black rot (Elsinoe glycines), black spot (Diaporthe phas)
eololum), kidney anthracnose (Colletotrichum lindem)
uthianum), Peanut black spot (Mycosphaerella per
sonatum), brown spot (Cercospora arachidicola), pea powdery mildew (Erysiphe pisi), potato summer blight (Alternaria solani), strawberry powdery mildew (Sph
aerotheca humuli), tea net blast (Exobasidium re
ticulatum), scab (Elsinoe leucospila), tobacco scab (Alternaria longipes), powdery mildew (Erysi)
phe cichoracearum, anthracnose (Colletotrichum tabacu)
m), brown spot of sugar beet (Cercospora beticola), rose scab (Diplocarpon rosae), powdery mildew (Sphaero
theca pannosa), brown spot of chrysanthemum (Septoria chrysanthe)
miindici), white rust (Puccinia horiana), gray mold on various crops (Botrytis cinerea), sclerotium on various crops (Sclerotinia sclerotiorum), and the like.

That is, the compound of the present invention effectively inhibits pests and plant diseases of Orthoptera, Hemiptera, Lepidoptera, Coleoptera, Hymenoptera, Diptera, Termites and Mite and Lice at low concentrations. Can be controlled. On the other hand, the compounds of the present invention include extremely useful compounds having almost no adverse effects on mammals, fish, crustaceans and beneficial insects.

The compound of the present invention can be synthesized by the following method (Scheme 1). Scheme 1

[0292]

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[In Scheme 1, Q, A and B have the same meanings as described above, and L ¹ and L ² are good leaving groups such as chlorine, bromine, iodine, C ₁ -C ₄ Alkylsulfonyloxy, benzenesulfonyloxy, toluenesulfonyloxy, C _{1 to} C ₄ alkoxy, phenoxy, 1-pyrazolyl or 1-imidazolyl,
L ³ represents a good leaving group such as a chlorine atom, a bromine atom, an iodine atom, C ₁ -C ₄ alkylsulfonyloxy, benzenesulfonyloxy, toluenesulfonyloxy and the like. In the method A in (Scheme 1), the compound (1 ′) of the present invention is synthesized by reacting an acetonitrile derivative represented by the general formula (2) with a carboxylic acid derivative represented by the general formula (3). It can be further expressed by the general formula (4)
Represents that the compound of the present invention (1) is obtained by reacting with the compound represented by Specific examples of the compound represented by the general formula (4) include acid halides, alkyl halides, alkyl sulfonates, benzene sulfonates, toluene sulfonates, sulfamoyl chlorides, thiocarbamoyl chlorides, and amides. It is. At this time, depending on the type of B in the compound (1) of the present invention, the compound (1 ′) of the present invention can be synthesized by reacting dihydropyran, isocyanates or thioisocyanates. Method B in (Scheme 1) shows a method of synthesizing the compound (1 ′) of the present invention by reacting the compound represented by the general formula (5) with the cyanoketone derivative represented by the general formula (6).

In some cases, it is preferable to use a base in the method described above. Examples of the base used include alkali metal alkoxides such as sodium ethoxide, sodium methoxide and potassium t-butoxide, alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, and alkali metal carbonates such as sodium carbonate and potassium carbonate. And organic bases such as triethylamine, pyridine and DBU, organic lithium compounds such as butyllithium, lithium amides such as lithium diisopropylamide and lithium bistrimethylsilylamide, and sodium hydride.

The reaction described in Scheme 1 can be carried out in a solvent inert to the reaction. Examples of the solvent include lower alcohols such as methanol and ethanol, aromatic hydrocarbons such as benzene and toluene, diethyl ether, and the like. Ethers such as tetrahydrofuran, 1,4-dioxane, 1,2-dimethoxyethane and 1,2-diethoxyethane, ketones such as acetone, methyl ethyl ketone and methyl isobutyl ketone, methylene chloride, chloroform and 1,2-dichloroethane Halogenated hydrocarbons,
Dimethylformamide, dimethylacetamide and 1,
Examples thereof include amides such as 3-dimethylimidazolidinone, nitriles such as acetonitrile, dimethyl sulfoxide, and a mixed solvent thereof. In some cases, a mixed solvent of these solvents and water can also be used.
Good results may be obtained by adding a quaternary ammonium salt such as n-butylammonium bromide as a catalyst. The reaction temperature can be set at any temperature from -70 ° C to 200 ° C, and preferably from 0 ° C to 150 ° C, or from -70 ° C to the boiling point of the solvent when a solvent is used. The base contains 0.05 to 10 equivalents of the reaction substrate,
Preferably it is in the range of 0.05 to 3 equivalents.

The compound of the present invention can be obtained from the reaction solution by a conventional method. However, if it becomes necessary to purify the compound of the present invention, it can be separated and purified by any purification method such as recrystallization, column chromatography and the like. Can be.

Among the compounds included in the present invention, compounds having an asymmetric carbon include optically active compounds (+) and (-).

Examples of the compounds included in the present invention are shown in Table 1. The abbreviations in the table have the following meanings.

Me: methyl, Et: ethyl, Pr: propyl, Bu: butyl, Pen: pentyl, Hex: hexyl, Hep: heptyl, Oct: octyl, Non: nonyl, Dec: decyl, Ph: phenyl, n: normal , I: iso, sec: secondary, t: tertiary,
c: cyclo,

[0300]

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[0301]

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[Table 1]

[0303]

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[0304]

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[0305]

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[0306]

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[0307]

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[0308]

[Table 1] ――――――――――――――――――――――――――    W EA ――――――――――――――――――――――――――    Ph O A1   2-Cl-Ph O A1   3-Cl-Ph O A1   4-Cl-Ph O A1   2,3-Cl_Two-Ph O A1   2,4-Cl_Two-Ph O A1   2,5-Cl_Two-Ph O A1   2,6-Cl_Two-Ph O A1   2,4,6-Cl_Three-Ph O A1   2-Br-Ph O A1   3-Br-Ph O A1   4-Br-Ph O A1   2,3-Br_Two-Ph O A1   2,4-Br_Two-Ph O A1   2,5-Br_Two-Ph O A1   2,6-Br_Two-Ph O A1   2-F-Ph O A1   3-F-Ph O A1   4-F-Ph O A1   2,3-F_Two-Ph O A1   2,4-F_Two-Ph O A1   2,5-F_Two-Ph O A1   2,6-F_Two-Ph O A1   2-Me-Ph O A1   3-Me-Ph O A1   4-Me-Ph O A1   2,3-Me_Two-Ph O A1   2,4-Me_Two-Ph O A1   2,5-Me_Two-Ph O A1   2,6-Me_Two-Ph O A1   4-nBu-Ph O A1   4-tBu-Ph O A1   2-CF_Three-Ph O A1   3-CF_Three-Ph O A1   4-CF_Three-Ph O A1   4-cHex-Ph O A1   3-OMe-Ph O A1   4-nBuO-Ph O A1   2-OCF_Three-Ph O A1   3-OCF_Three-Ph O A1   4-OCF_Three-Ph O A1   2-SMe-Ph O A1   4-SMe-Ph O A1   4-SO_TwoMe-Ph O A1   4-SO_TwoCF_Three-Ph O A1   4-NO_Two-Ph O A1   4-phenoxy-Ph               O A1   4-CO_TwoMe-Ph O A1   2-naphthyl                   O A1   3-naphthyl                   O A1   3-thienyl                   O A1   2-oxasodilyl                O A1   3-Hydrazolyl                O A1   5-Hydrazole                O A1   1,3,4-oxathiazol-2-yl    O A1   1,3,4-thiazolazole-2-yl     O A1  5-Me-1,3,4-thiazazole-2-yl O A1   5-Me-Puridine-2-yl O A1   5-Et-Puridine-2-yl O A1   5-NO_Two-Pulse-2-yl O A1   5-CF_Three-Pulse-2-yl O A1   3-Piryl O A1   4-Peel O A1   2-pyrimidinyl O A1   4-CF_Three-Hypermicin-2-yl O A1   2-Hensooxaoxalyl O A1   2-benzothiazole O A1   3-Intersolyl O A1   2-intryl O A1   3-intryl O A1   2-quinolyl O A1   3-quinolyl O A1   1-isoquinolyl O A1   3-isoquinolyl O A1    Ph S A1   2-Cl-Ph S A1   3-Cl-Ph S A1   4-Cl-Ph S A1   2,3-Cl_Two-Ph S A1   2,4-Cl_Two-Ph S A1   2,5-Cl_Two-Ph S A1   2,6-Cl_Two-Ph S A1   2,4,6-Cl_Three-Ph S A1   2-Br-Ph S A1   3-Br-Ph S A1   4-Br-Ph S A1   2,3-Br_Two-Ph S A1   2,4-Br_Two-Ph S A1   2,5-Br_Two-Ph S A1   2,6-Br_Two-Ph S A1   2-F-Ph S A1   3-F-Ph S A1   4-F-Ph S A1   2,3-F_Two-Ph S A1   2,4-F_Two-Ph S A1   2,5-F_Two-Ph S A1   2,6-F_Two-Ph S A1   2-Me-Ph S A1   3-Me-Ph S A1   4-Me-Ph S A1   2,3-Me_Two-Ph S A1   2,4-Me_Two-Ph S A1   2,5-Me_Two-Ph S A1   2,6-Me_Two-Ph S A1   4-nBu-Ph S A1   4-tBu-Ph S A1   2-CF_Three-Ph S A1   3-CF_Three-Ph S A1   4-CF_Three-Ph S A1   2-OMe-Ph S A1   4-nBuO-Ph S A1   4-Phenyloxy-Ph S A1   4-allyloxy-Ph S A1   2-OCF_Three-Ph S A1   2-Peel S A1   5-Me-Puridine-2-yl S A1   5-Et-Puridine-2-yl S A1   5-NO_Two-Pulse-2-yl S A1   5-CF_Three-Pulse-2-yl S A1   3-Primary S A1   2-Primidinyl S A1   4-CF_Three-Primetic-2 -yl S A1   2-Hensooxaxoryl S A1   2-Hensothiazolyl S A1   2-quinolyl S A1    Ph NH A1    Ph NMe A1   2-Cl-Ph NMe A1   3-Cl-Ph NMe A1   4-Cl-Ph NMe A1   2,4-Cl_Two-Ph NMe A1   2-Br-Ph NMe A1   4-F-Ph NMe A1   2,6-F_Two-Ph NMe A1   2-Me-Ph NMe A1   3-Me-Ph NMe A1   4-Me-Ph NMe A1   4-nBu-Ph NMe A1   4-tBu-Ph NMe A1   2-CF_Three-Ph NMe A1   4-CF_Three-Ph NMe A1   2-OMe-Ph NMe A1   3-OMe-Ph NMe A1   4-nBuO-Ph NMe A1   2-OCF_Three-Ph NMe A1   3-OCF_Three-Ph NMe A1   4-OCF_Three-Ph NMe A1   4-CN-Ph NMe A1   4-phenoxy-Ph               NMe A1   4-CO_TwoMe-Ph NMe A1   5-Hydrazole                NMe A1   1,3,4-thiazolazole-2-yl     NMe A1  5-Me-1,3,4-thiazazole-2-yl NMe A1   2-Primary NMe A1   2-pyrimidinyl NMe A1   2-Hensooxaoxaril NMe A1   2-benzothiazole NMe A1   2-quinolyl NMe A1    Ph SO A1   2-Cl-Ph SO A1   3-Cl-Ph SO A1   4-Cl-Ph SO A1   2,4-Cl_Two-Ph SO A1   2,4,6-Cl_Three-Ph SO A1   2-Br-Ph SO A1   4-F-Ph SO A1   2,6-F_Two-Ph SO A1   2-Me-Ph SO A1   3-Me-Ph SO A1   4-Me-Ph SO A1   2,4-Me_Two-Ph SO A1   4-nBu-Ph SO A1   4-tBu-Ph SO A1   2-CF_Three-Ph SO A1   3-CF_Three-Ph SO A1   4-CF_Three-Ph SO A1   4-cHex-Ph SO A1   3-OMe-Ph SO A1   4-nBuO-Ph SO A1   2-OCF_Three-Ph SO A1   3-OCF_Three-Ph SO A1   4-OCF_Three-Ph SO A1   4-NO_Two-Ph SO A1   4-CN-Ph SO A1   4-phenoxy-Ph               SO A1   4-CO_TwoMe-Ph SO A1   2-naphthyl                   SO A1   3-naphthyl                   SO A1   2-thiazole                 SO A1   5-Hydrazole                SO A1   1,3,4-oxathiazol-2-yl    SO A1   1,3,4-thiazolazole-2-yl     SO A1  5-Me-1,3,4-thiazolazole-2-yl SO A1   2-Phil SO1   2-Primidinyl SO A1   2-benzene oxasoryl SO A1   2-Hensothiazole SO A1   2-quinolyl SO A1   nBu SO A1   tBu SO A1   CH_Two-CH = CH_Two               SO A1   CH_Two-C≡CH SO A1   CF (CF_Three)_Two                 SO A1   CH_Two-CH = CF_Two               SO A1   CH_TwoPh SO A1   CH_Two(4-Cl-Ph) SO A1    Ph SO_Two                A1   2-Cl-Ph SO_Two                A1   3-Cl-Ph SO_Two                A1   4-Cl-Ph SO_Two                A1   2,3-Cl_Two-Ph SO_Two                A1   2,4-Cl_Two-Ph SO_Two                A1   2,4,6-Cl_Three-Ph SO_Two                A1   2-Br-Ph SO_Two                A1   4-F-Ph SO_Two                A1   2,6-F_Two-Ph SO_Two                A1   2-Me-Ph SO_Two                A1   3-Me-Ph SO_Two                A1   4-Me-Ph SO_Two                A1   2,4-Me_Two-Ph SO_Two                A1   4-nBu-Ph SO_Two                A1   4-tBu-Ph SO_Two                A1   2-CF_Three-Ph SO_Two                A1   3-CF_Three-Ph SO_Two                A1   4-CF_Three-Ph SO_Two                A1   4-cHex-Ph SO_Two                A1   2-OMe-Ph SO_Two                A1   3-OMe-Ph SO_Two                A1   4-OMe-Ph SO_Two                A1   4-nBuO-Ph SO_Two                A1   2-OCF_Three-Ph SO_Two                A1   3-OCF_Three-Ph SO_Two                A1   4-OCF_Three-Ph SO_Two                A1   4-SO_TwoMe-Ph SO_Two                A1   4-SO_TwoCF_Three-Ph SO_Two                A1   4-NO_Two-Ph SO_Two                A1   4-CN-Ph SO_Two                A1   4-phenoxy-Ph               SO_Two                A1   4-CO_TwoMe-Ph SO_Two                A1   4-Phenyl-Ph              SO_Two                A1   3-naphthyl                   SO_Two                A1   2-thiazole                 SO_Two                A1   3-Hydrazolyl                SO_Two                A1   1,3,4-oxathiazol-2-yl    SO_Two                A1   1,3,4-thiazolazole-2-yl     SO_Two                A1  5-Me-1,3,4-thiazazole-2-yl SO_Two                A1   2-Philsil SO_Two                A1   2-pyrimidinyl SO_Two                A1   2-Hensooxaoxaril SO_Two                A1   2-Hensothiazole SO_Two                A1   2-quinolyl SO_Two                A1   nBu SO_Two                A1   tBu SO_Two                A1   CH_Two-CH = CH_Two               SO_Two                A1   CH_Two-C≡CH SO_Two                A1   CF_Three                      SO_Two                A1   CF (CF_Three)_Two                 SO_Two                A1   CH_Two-CH = CF_Two               SO_Two                A1   cHex SO_Two                A1   CH_TwoPh SO_Two                A1   CH_Two(4-Cl-Ph) SO_Two                A1   CH_Two(2-thienyl) SO_Two                A1   CH_Two(2-Phil) SO_Two                A1   CH_Two(3-Phil) SO_Two                A1   CH_Two(4-Phil) SO_Two                A1    Ph O A2   2-Cl-Ph O A2   3-Cl-Ph O A2   4-Cl-Ph O A2   2,3-Cl_Two-Ph O A2   2,4-Cl_Two-Ph O A2   2,5-Cl_Two-Ph O A2   2,6-Cl_Two-Ph O A2   2,4,6-Cl_Three-Ph O A2   2-Br-Ph O A2   3-Br-Ph O A2   4-Br-Ph O A2   2,3-Br_Two-Ph O A2   2,4-Br_Two-Ph O A2   2,5-Br_Two-Ph O A2   2,6-Br_Two-Ph O A2   2-F-Ph O A2   3-F-Ph O A2   4-F-Ph O A2   2,3-F_Two-Ph O A2   2,4-F_Two-Ph O A2   2,5-F_Two-Ph O A2   2,6-F_Two-Ph O A2   2-Me-Ph O A2   3-Me-Ph O A2   4-Me-Ph O A2   2,3-Me_Two-Ph O A2   2,4-Me_Two-Ph O A2   2,5-Me_Two-Ph O A2   2,6-Me_Two-Ph O A2   4-nBu-Ph O A2   4-tBu-Ph O A2   4-Phenyl-Ph O A2   4-allyl-Ph O A2   2-fluoroalkyl-Ph O A2   2-CF_Three-Ph O A2   3-CF_Three-Ph O A2   4-CF_Three-Ph O A2   2-cPr-Ph O A2   3-cPr-Ph O A2   4-cPr-Ph O A2   4-cHex-Ph O A2   2-OMe-Ph O A2   3-OMe-Ph O A2   4-OMe-Ph O A2   4-nBuO-Ph O A2   4-Phenyloxy-Ph O A2   4-allyloxy-Ph O A2   2-fluoroalkyloxy-Ph O A2   2-OCF_Three-Ph O A2   3-OCF_Three-Ph O A2   4-OCF_Three-Ph O A2   4-hexyl-Ph O A2   2-SMe-Ph O A2   3-SMe-Ph O A2   4-SMe-Ph O A2   4-SOMe-Ph O A2   4-SO_TwoMe-Ph O A2   4-SCF_Three-Ph O A2   4-SOCF_Three-Ph O A2   4-SO_TwoCF_Three-Ph O A2   4-CN-Ph O A2   4-NMe_Two-Ph O A2   4-phenoxy-Ph               O A2   4-CO_TwoMe-Ph O A2   4-COMe-Ph      O A2   4-Hensoil-Ph             O A2   4-Ph-Ph                  O A2   4-Phil-Ph              O A2   4-thienyl-Ph                O A2   2-naphthyl                   O A2   3-naphthyl                   O A2   2-thienyl                   O A2   3-thienyl                   O A2   2-furil                   O A2   3-furil                    O A2   2-hydroxyl                  O A2   3-hydroxyl                  O A2   2-oxasodilyl                O A2   4-oxasopril                O A2   5-oxasopril                O A2   3-isoxazoduryl               O A2   4-isoxazoduryl               O A2   5-isoxazoduryl               O A2   2-thiazole                 O A2   4-thiazole                 O A2   5-thiazolyl                 O A2   3-isothiazole               O A2   4-isothiazodyl               O A2   5-isothiazole               O A2   3-Hydrazolyl                O A2   4-Hyperazole                O A2   5-Hydrazole                O A2   2-Imitation Soril               O A2   4-Imitation Soril               O A2   5-Imitation Soril               O A2   1,3,4-oxathiazol-2-yl    O A2   1,2,4-oxathiazol-3-yl    O A2   1,2,4-oxathiazol-5-yl    O A2   1,3,4-thiazolazole-2-yl     O A2  5-Me-1,3,4-thiadiazol-2-yl O A2   1,2,4-thiazolazole-3-yl     O A2   1,2,4-thiazolazole-5-yl     O A2   1,2,4-triazol-3-yl       O A2   1,2,4-triazole-5-yl       O A2   1,2,3-thiazolazole-4-yl     O A2   1,2,3-thiazolazole-5-yl     O A2   1,2,3-triazole-4-yl       O A2   1,2,3-triazole-5-yl       O A2   1,2,3,4-tetrasole-5-yl     O A2   2-Philly O2   5-Me-Puridine-2-yl O A2   5-Et-Puridine-2-yl O A2   5-NO_Two-Pulse-2-yl O A2   5-CF_Three-Pulse-2-yl O A2   3-Philsil O A2   4-Peel O A2   2-pyrimidinyl O A2   4-CF_Three-Hypermicin-2-yl O A2   4-Primidinyl O A2   5-Primidinyl O A2   2-Pirazine O A2   3-Pyritacinil O A2   4-Pyritacinil O A2   1,3,5-triashidin-2-yl        O A2   1,2,4-triashidin-3-yl        O A2   1,2,4-triazine-5-yl        O A2   1,2,4-triazine-6-yl        O A2   2-Hensooxaoxalyl O A2   2-benzothiasorbyl O A2   2-benzene immobilizer O A2   3-Intersolyl O A2   2-intryl O A2   3-intryl O A2   3-benzeneisoxazolyl O A2   3-Hensone isothiazolyl O A2   4-benzotriazole O A2   4-Hensooxaoxaril O A2   4-Hensothiazole R O A2   2-quinolyl O A2   3-quinolyl O A2   4-quinolyl O A2   5-quinolyl O A2   6-quinolyl O A2   7-quinolyl O A2   8-quinolyl O A2   1-isoquinolyl O A2   3-isoquinolyl O A2   4-isoquinolyl O A2   5-isoquinolyl O A2   6-isoquinolyl O A2   7-isoquinolyl O A2   8-isoquinolyl O A2   2-quinoxalinyl O A2   5-quinoxalinyl O A2   6-quinoxalinyl O A2   1-phthalacidinyl O A2   5-phthalacidinyl O A2   6-phthalacidinyl O A2   3-cinnolinyl O A2   4-cinnolinyl O A2   5-cinnolinyl O A2   6-cinnolinyl O A2   7-cinnolinyl O A2   8-cinnolinyl O A2   2-quinazodolinyl O A2   4-Quinazoperinyl O A2   5-quinazodolinyl O A2   6-Quinazoperinyl O A2   7-Quinazoperinyl O A2   8-Quinazoperinyl O A2    Ph S A2   2-Cl-Ph S A2   3-Cl-Ph S A2   4-Cl-Ph S A2   2,3-Cl_Two-Ph S A2   2,4-Cl_Two-Ph S A2   2,5-Cl_Two-Ph S A2   2,6-Cl_Two-Ph S A2   2,4,6-Cl_Three-Ph S A2   2-Br-Ph S A2   3-Br-Ph S A2   4-Br-Ph S A2   2,3-Br_Two-Ph S A2   2,4-Br_Two-Ph S A2   2,5-Br_Two-Ph S A2   2,6-Br_Two-Ph S A2   2-F-Ph S A2   3-F-Ph S A2   4-F-Ph S A2   2,3-F_Two-Ph S A2   2,4-F_Two-Ph S A2   2,5-F_Two-Ph S A2   2,6-F_Two-Ph S A2   2-Me-Ph S A2   3-Me-Ph S A2   4-Me-Ph S A2   2,3-Me_Two-Ph S A2   2,4-Me_Two-Ph S A2   2,5-Me_Two-Ph S A2   2,6-Me_Two-Ph S A2   4-nBu-Ph S A2   4-tBu-Ph S A2   4-Phenyl-Ph S A2   4-allyl-Ph S A2   2-fluoroalkyl-Ph S A2   2-CF_Three-Ph S A2   3-CF_Three-Ph S A2   4-CF_Three-Ph S A2   2-cPr-Ph S A2   3-cPr-Ph S A2   4-cPr-Ph S A2   4-cHex-Ph S A2   2-OMe-Ph S A2   3-OMe-Ph S A2   4-OMe-Ph S A2   4-nBuO-Ph S A2   4-Phenyloxy-Ph S A2   4-allyloxy-Ph S A2   2-fluoroalkyloxy-Ph S A2   2-OCF_Three-Ph S A2   3-OCF_Three-Ph S A2   4-OCF_Three-Ph S A2   4-Hensyl-Ph S A2   2-SMe-Ph S A2   3-SMe-Ph S A2   4-SMe-Ph S A2   4-SOMe-Ph S A2   4-SO_TwoMe-Ph S A2   4-SCF_Three-Ph S A2   4-SOCF_Three-Ph S A2   4-SO_TwoCF_Three-Ph S A2   4-NO_Two-Ph S A2   4-CN-Ph S A2   4-NMe_Two-Ph S A2   4-phenoxy-Ph               S A2   4-CO_TwoMe-Ph S A2   4-COMe-Ph      S A2   4-Hensoil-Ph             S A2   4-Ph-Ph                  S A2   4-Phenyl-Ph              S A2   4-thienyl-Ph                S A2   2-naphthyl                   S A2   3-naphthyl                   S A2   2-thienyl                   S A2   3-thienyl                   S A2   2-furil                   S A2   3-furil                    S A2   2-hydroxyl                  S A2   3-hydroxyl                  S A2   2-oxasodilyl                S A2   4-oxasopril                S A2   5-oxasopril                S A2   3-isoxazoduryl               S A2   4-isoxazoduryl               S A2   5-isoxazoduryl               S A2   2-thiazole                 S A2   4-thiazole                 S A2   5-thiazolyl                 S A2   3-isothiazole               S A2   4-isothiazodyl               S A2   5-isothiazole               S A2   3-Hydrazolyl                S A2   4-Hyperazole                S A2   5-Hydrazole                S A2   2-Imitation Soril               S A2   4-Imitation Soril               S A2   5-Imitation Soril               S A2   1,3,4-oxathiazol-2-yl    S A2   1,2,4-oxathiazol-3-yl    S A2   1,2,4-oxathiazol-5-yl    S A2   1,3,4-thiazolazole-2-yl     S A2  5-Me-1,3,4-thiadiazol-2-yl S A2   1,2,4-thiazolazole-3-yl     S A2   1,2,4-thiazolazole-5-yl     S A2   1,2,4-triazol-3-yl       S A2   1,2,4-triazole-5-yl       S A2   1,2,3-thiazolazole-4-yl     S A2   1,2,3-thiazolazole-5-yl     S A2   1,2,3-triazole-4-yl       S A2   1,2,3-triazole-5-yl       S A2   1,2,3,4-tetrasole-5-yl     S A2   2-Peel S A2   5-Me-Puridine-2-yl S A2   5-Et-Puridine-2-yl S A2   5-NO_Two-Pulse-2-yl S A2   5-CF_Three-Pulse-2-yl S A2   3-Primary S A2   4-Peel S A2   2-Primidinyl S A2   4-CF_Three-Primishin-2-yl S A2   4-Primidinyl S A2   5-Primidinyl S A2   2-Pirazinyl S A2   3-Horitacinil S A2   4-Horitacinyl S A2   1,3,5-triashidin-2-yl        S A2   1,2,4-triashidin-3-yl        S A2   1,2,4-triazine-5-yl        S A2   1,2,4-triazine-6-yl        S A2   2-benzoxazole S A2   2-benzothiazole S A2   2-Hensor immobilizer S A2   3-Intersolor S A2   2-intryl S A2   3-intryl S A2   3-Hensone isoxasorbyl S A2   3-Hensone isothiazolyl S A2   4-Hensotriazole S A2   4-Hensooxaoxaril S A2   4-Hensothi assril S A2   2-quinolyl S A2   3-quinolyl S A2   4-quinolyl S A2   5-quinolyl S A2   6-quinolyl S A2   7-quinolyl S A2   8-quinolyl S A2   1-isoquinolyl S A2   3-isoquinolyl S A2   4-isoquinolyl S A2   5-isoquinolyl S A2   6-isoquinolyl S A2   7-isoquinolyl S A2   8-isoquinolyl S A2   2-quinoxalinyl S A2   5-quinoxalinyl S A2   6-quinoxalinyl S A2   1-phthalacidinyl S A2   5-phthalacidinyl S A2   6-phthalazinyl S A2   3-cinnolinyl S A2   4-cinnolinyl S A2   5-cinnolinyl S A2   6-cinnolinyl S A2   7-cinnolinyl S A2   8-cinnolinyl S A2   2-Quinazoperinyl S A2   4-Quinazoperinyl S A2   5-Quinazoperinyl S A2   6-Quinazoperinyl S A2   7-Quinazoperinyl S A2   8-Quinazoperinyl S A2    Ph NH A2    Ph NMe A2   2-Cl-Ph NMe A2   3-Cl-Ph NMe A2   4-Cl-Ph NMe A2   2,3-Cl_Two-Ph NMe A2   2,4-Cl_Two-Ph NMe A2   2,4,6-Cl_Three-Ph NMe A2   2-Br-Ph NMe A2   4-F-Ph NMe A2   2,6-F_Two-Ph NMe A2   2-Me-Ph NMe A2   3-Me-Ph NMe A2   4-Me-Ph NMe A2   2,4-Me_Two-Ph NMe A2   4-nBu-Ph NMe A2   4-tBu-Ph NMe A2   4-Phenyl-Ph NMe A2   4-allyl-Ph NMe A2   2-fluoroalkyl-Ph NMe A2   2-CF_Three-Ph NMe A2   3-CF_Three-Ph NMe A2   4-CF_Three-Ph NMe A2   4-cPr-Ph NMe A2   4-cHex-Ph NMe A2   2-OMe-Ph NMe A2   3-OMe-Ph NMe A2   4-OMe-Ph NMe A2   4-nBuO-Ph NMe A2   4-Phenyloxy-Ph NMe A2   4-allyloxy-Ph NMe A2   2-fluoroalkyloxy-Ph NMe A2   2-OCF_Three-Ph NMe A2   3-OCF_Three-Ph NMe A2   4-OCF_Three-Ph NMe A2   2-SMe-Ph NMe A2   3-SMe-Ph NMe A2   4-SMe-Ph NMe A2   4-SOMe-Ph NMe A2   4-SO_TwoMe-Ph NMe A2   4-SCF_Three-Ph NMe A2   4-SOCF_Three-Ph NMe A2   4-SO_TwoCF_Three-Ph NMe A2   4-NO_Two-Ph NMe A2   4-CN-Ph NMe A2   4-NMe_Two-Ph NMe A2   4-phenoxy-Ph               NMe A2   4-CO_TwoMe-Ph NMe A2   4-COMe-Ph      NMe A2   4-Hensoil-Ph             NMe A2   4-Ph-Ph                  NMe A2   4-Phenyl-Ph              NMe A2   4-thienyl-Ph                NMe A2   2-naphthyl                   NMe A2   3-naphthyl                   NMe A2   2-thienyl                   NMe A2   3-thienyl                   NMe A2   2-furil                   NMe A2   3-furil                    NMe A2   2-hydroxyl                  NMe A2   3-hydroxyl                  NMe A2   2-oxasodilyl                NMe A2   4-oxasopril                NMe A2   5-oxasopril                NMe A2   3-isoxazoduryl               NMe A2   4-isoxazoduryl               NMe A2   5-isoxazoduryl               NMe A2   2-thiazole                 NMe A2   4-thiazole                 NMe A2   5-thiazolyl                 NMe A2   3-isothiazole               NMe A2   4-isothiazodyl               NMe A2   5-isothiazole               NMe A2   3-Hydrazolyl                NMe A2   4-Hyperazole                NMe A2   5-Hydrazole                NMe A2   2-Imitation Soril               NMe A2   4-Imitation Soril               NMe A2   5-Imitation Soril               NMe A2   1,3,4-oxathiazol-2-yl    NMe A2   1,2,4-oxathiazol-3-yl    NMe A2   1,2,4-oxathiazol-5-yl    NMe A2   1,3,4-thiazolazole-2-yl     NMe A2  5-Me-1,3,4-thiadiazol-2-yl NMe A2   1,2,4-thiazolazole-3-yl     NMe A2   1,2,4-thiazolazole-5-yl     NMe A2   1,2,4-triazol-3-yl       NMe A2   1,2,4-triazole-5-yl       NMe A2   1,2,3-thiazolazole-4-yl     NMe A2   1,2,3-thiazolazole-5-yl     NMe A2   1,2,3-triazole-4-yl       NMe A2   1,2,3-triazole-5-yl       NMe A2   1,2,3,4-tetrasole-5-yl     NMe A2   2-Primary NMe A2   3-Primary NMe A2   4-Primary NMe A2   2-Primidinyl NMe A2   2-Pirazine NMe A2   3-Horitacinil NMe A2   1,3,5-triashidin-2-yl        NMe A2   1,2,4-triashidin-3-yl        NMe A2   1,2,4-triazine-5-yl        NMe A2   1,2,4-triazine-6-yl        NMe A2   2-benzoxazole NMe A2   2-benzothiazole NMe A2   2-benzene immobilizer NMe A2   3-Intersoryl NMe A2   2-intryl NMe A2   3-intyryl NMe A2   3-benzeneisoxazolyl NMe A2   3-Hensone isothiazolyl NMe A2   4-benzotriazole NMe A2   4-Hensooxaoxaril NMe A2   4-Hensothiazole NMe A2   2-quinolyl NMe A2   1-isoquinolyl NMe A2   2-quinoxalinyl NMe A2   1-phthalacidinyl NMe A2   3-cinnolinyl NMe A2   2-Quinazoperinyl NMe A2    Ph SO A2   2-Cl-Ph SO A2   3-Cl-Ph SO A2   4-Cl-Ph SO A2   2,3-Cl_Two-Ph SO A2   2,4-Cl_Two-Ph SO A2   2,4,6-Cl_Three-Ph SO A2   2-Br-Ph SO A2   4-F-Ph SO A2   2,6-F_Two-Ph SO A2   2-Me-Ph SO A2   3-Me-Ph SO A2   4-Me-Ph SO A2   2,4-Me_Two-Ph SO A2   4-nBu-Ph SO A2   4-tBu-Ph SO A2   4-Phenyl-Ph SO A2   4-allyl-Ph SO A2   2-fluoroalkyl-Ph SO A2   2-CF_Three-Ph SO A2   3-CF_Three-Ph SO A2   4-CF_Three-Ph SO A2   4-cPr-Ph SO A2   4-cHex-Ph SO A2   2-OMe-Ph SO A2   3-OMe-Ph SO A2   4-OMe-Ph SO A2   4-nBuO-Ph SO A2   4-Phenyloxy-Ph SO A2   4-allyloxy-Ph SO A2   2-fluoroalkyloxy-Ph SO A2   2-OCF_Three-Ph SO A2   3-OCF_Three-Ph SO A2   4-OCF_Three-Ph SO A2   2-SMe-Ph SO A2   3-SMe-Ph SO A2   4-SMe-Ph SO A2   4-SOMe-Ph SO A2   4-SO_TwoMe-Ph SO A2   4-SCF_Three-Ph SO A2   4-SOCF_Three-Ph SO A2   4-SO_TwoCF_Three-Ph SO A2   4-NO_Two-Ph SO A2   4-CN-Ph SO A2   4-NMe_Two-Ph SO A2   4-phenoxy-Ph               SO A2   4-CO_TwoMe-Ph SO A2   4-COMe-Ph      SO A2   4-Hensoil-Ph             SO A2   4-Ph-Ph                  SO A2   4-Phenyl-Ph              SO A2   4-thienyl-Ph                SO A2   2-naphthyl                   SO A2   3-naphthyl                   SO A2   2-thienyl                   SO A2   3-thienyl                   SO A2   2-furil                   SO A2   3-furil                    SO A2   2-hydroxyl                  SO A2   3-hydroxyl                  SO A2   2-oxasodilyl                SO A2   4-oxasopril                SO A2   5-oxasopril                SO A2   3-isoxazoduryl               SO A2   4-isoxazoduryl               SO A2   5-isoxazoduryl               SO A2   2-thiazole                 SO A2   4-thiazole                 SO A2   5-thiazolyl                 SO A2   3-isothiazole               SO A2   4-isothiazodyl               SO A2   5-isothiazole               SO A2   3-Hydrazolyl                SO A2   4-Hyperazole                SO A2   5-Hydrazole                SO A2   2-Imitation Soril               SO A2   4-Imitation Soril               SO A2   5-Imitation Soril               SO A2   1,3,4-oxathiazol-2-yl    SO A2   1,2,4-oxathiazol-3-yl    SO A2   1,2,4-oxathiazol-5-yl    SO A2   1,3,4-thiazolazole-2-yl     SO A2  5-Me-1,3,4-thiazazole-2-yl SO A2   1,2,4-thiazolazole-3-yl     SO A2   1,2,4-thiazolazole-5-yl     SO A2   1,2,4-triazol-3-yl       SO A2   1,2,4-triazole-5-yl       SO A2   1,2,3-thiazolazole-4-yl     SO A2   1,2,3-thiazolazole-5-yl     SO A2   1,2,3-triazole-4-yl       SO A2   1,2,3-triazole-5-yl       SO A2   1,2,3,4-tetrasole-5-yl     SO A2   2-Philsil SO A2   3-Prior SO A2   4-Prior SO A2   2-Primidinyl SO A2   2-Pirazinil SO A2   3-Horitacinil SO A2   1,3,5-triashidin-2-yl        SO A2   1,2,4-triashidin-3-yl        SO A2   1,2,4-triazine-5-yl        SO A2   1,2,4-triazine-6-yl        SO A2   2-Hensooxaoxalyl SO A2   2-Hensothiazole SO A2   2-Hensor immobilizer SO A2   3-Intersolor SO A2   2-intryl SO A2   3-intril SO A2   3-Hensone isoxasorbyl SO A2   3-benzene isothiazole SO A2   4-Hensotriazole SO A2   4-Hensooxaoxaril SO A2   4-Hensothi assiril SO A2   2-quinolyl SO A2   1-isoquinolyl SO A2   2-quinoxalinyl SO A2   1-phthalazinyl SO A2   3-cinnolinyl SO A2   2-quinazodolinyl SO A2   nBu SO A2   tBu SO A2   CH_Two-CH = CH_Two               SO A2   CH_Two-C≡CH SO A2   CF_Three                      SO A2   CF (CF_Three)_Two                 SO A2   CH_Two-CH = CF_Two               SO A2   cHex SO A2   CH_TwoOCH_Three                  SO A2   CH_TwoSCH_Three                  SO A2   CH_TwoPh SO A2   CH_Two(4-Cl-Ph) SO A2   CH_TwoOPh SO A2   CH_TwoSPh SO A2   CH_TwoSOPh SO A2   CH_TwoSO_TwoPh SO A2   CH_TwoCOPh SO A2   CH_TwoCO_TwoPh SO A2   CH_Two(2-thienyl) SO A2   CH_Two(2-Phil) SO A2   CH_Two(3-basic) SO A2   CH_Two(4-basic) SO A2    Ph SO_Two                A2   2-Cl-Ph SO_Two                A2   3-Cl-Ph SO_Two                A2   4-Cl-Ph SO_Two                A2   2,3-Cl_Two-Ph SO_Two                A2   2,4-Cl_Two-Ph SO_Two                A2   2,4,6-Cl_Three-Ph SO_Two                A2   2-Br-Ph SO_Two                A2   4-F-Ph SO_Two                A2   2,6-F_Two-Ph SO_Two                A2   2-Me-Ph SO_Two                A2   3-Me-Ph SO_Two                A2   4-Me-Ph SO_Two                A2   2,4-Me_Two-Ph SO_Two                A2   4-nBu-Ph SO_Two                A2   4-tBu-Ph SO_Two                A2   4-Phenyl-Ph SO_Two                A2   4-allyl-Ph SO_Two                A2   2-fluoroalkyl-Ph SO_Two                A2   2-CF_Three-Ph SO_Two                A2   3-CF_Three-Ph SO_Two                A2   4-CF_Three-Ph SO_Two                A2   4-cPr-Ph SO_Two                A2   4-cHex-Ph SO_Two                A2   2-OMe-Ph SO_Two                A2   3-OMe-Ph SO_Two                A2   4-OMe-Ph SO_Two                A2   4-nBuO-Ph SO_Two                A2   4-Phenyloxy-Ph SO_Two                A2   4-allyloxy-Ph SO_Two                A2   2-fluoroalkyloxy-Ph SO_Two                A2   2-OCF_Three-Ph SO_Two                A2   3-OCF_Three-Ph SO_Two                A2   4-OCF_Three-Ph SO_Two                A2   2-SMe-Ph SO_Two                A2   3-SMe-Ph SO_Two                A2   4-SMe-Ph SO_Two                A2   4-SOMe-Ph SO_Two                A2   4-SO_TwoMe-Ph SO_Two                A2   4-SCF_Three-Ph SO_Two                A2   4-SOCF_Three-Ph SO_Two                A2   4-SO_TwoCF_Three-Ph SO_Two                A2   4-NO_Two-Ph SO_Two                A2   4-CN-Ph SO_Two                A2   4-NMe_Two-Ph SO_Two                A2   4-phenoxy-Ph               SO_Two                A2   4-CO_TwoMe-Ph SO_Two                A2   4-COMe-Ph      SO_Two                A2   4-Hensoil-Ph             SO_Two                A2   4-Ph-Ph                  SO_Two                A2   4-Phenyl-Ph              SO_Two                A2   4-thienyl-Ph                SO_Two                A2   2-naphthyl                   SO_Two                A2   3-naphthyl                   SO_Two                A2   2-thienyl                   SO_Two                A2   3-thienyl                   SO_Two                A2   2-furil                   SO_Two                A2   3-furil                    SO_Two                A2   2-hydroxyl                  SO_Two                A2   3-hydroxyl                  SO_Two                A2   2-oxasodilyl                SO_Two                A2   4-oxasopril                SO_Two                A2   5-oxasopril                SO_Two                A2   3-isoxazoduryl               SO_Two                A2   4-isoxazoduryl               SO_Two                A2   5-isoxazoduryl               SO_Two                A2   2-thiazole                 SO_Two                A2   4-thiazole                 SO_Two                A2   5-thiazolyl                 SO_Two                A2   3-isothiazole               SO_Two                A2   4-isothiazodyl               SO_Two                A2   5-isothiazole               SO_Two                A2   3-Hydrazolyl                SO_Two                A2   4-Hyperazole                SO_Two                A2   5-Hydrazole                SO_Two                A2   2-Imitation Soril               SO_Two                A2   4-Imitation Soril               SO_Two                A2   5-Imitation Soril               SO_Two                A2   1,3,4-oxathiazol-2-yl    SO_Two                A2   1,2,4-oxathiazol-3-yl    SO_Two                A2   1,2,4-oxathiazol-5-yl    SO_Two                A2   1,3,4-thiazolazole-2-yl     SO_Two                A2  5-Me-1,3,4-thiazazole-2-yl SO_Two                A2   1,2,4-thiazolazole-3-yl     SO_Two                A2   1,2,4-thiazolazole-5-yl     SO_Two                A2   1,2,4-triazol-3-yl       SO_Two                A2   1,2,4-triazole-5-yl       SO_Two                A2   1,2,3-thiazolazole-4-yl     SO_Two                A2   1,2,3-thiazolazole-5-yl     SO_Two                A2   1,2,3-triazole-4-yl       SO_Two                A2   1,2,3-triazole-5-yl       SO_Two                A2   1,2,3,4-tetrasole-5-yl     SO_Two                A2   2-Philsil SO_Two                A2   3-Primary SO_Two                A2   4-Phil Sir_Two                A2   2-pyrimidinyl SO_Two                A2   2-Pyrazine SO_Two                A2   3-Horitacinil SO_Two                A2   1,3,5-triashidin-2-yl        SO_Two                A2   1,2,4-triashidin-3-yl        SO_Two                A2   1,2,4-triazine-5-yl        SO_Two                A2   1,2,4-triazine-6-yl        SO_Two                A2   2-Hensooxaoxaril SO_Two                A2   2-Hensothiazole SO_Two                A2   2-Hensor immobilizer SO_Two                A2   3-Intersolyl SO_Two                A2   2-intryl SO_Two                A2   3-intril SO_Two                A2   3-Hensone isoxasoryl SO_Two                A2   3-Hensone isothiazolyl SO_Two                A2   4-Hensotriazole SO_Two                A2   4-Hensooxaoxaril SO_Two                A2   4-Hensothiazole SO_Two                A2   2-quinolyl SO_Two                A2   1-isoquinolyl SO_Two                A2   2-quinoxalinyl SO_Two                A2   1-phthalacinyl SO_Two                A2   3-cinnolinyl SO_Two                A2   2-Quinazoperinyl SO_Two                A2   nBu SO_Two                A2   tBu SO_Two                A2   CH_Two-CH = CH_Two               SO_Two                A2   CH_Two-C≡CH SO_Two                A2   CF_Three                      SO_Two                A2   CF (CF_Three)_Two                 SO_Two                A2   CH_Two-CH = CF_Two               SO_Two                A2   cHex SO_Two                A2   CH_TwoOCH_Three                  SO_Two                A2   CH_TwoSCH_Three                  SO_Two                A2   CH_TwoPh SO_Two                A2   CH_Two(4-Cl-Ph) SO_Two                A2   CH_TwoOPh SO_Two                A2   CH_TwoSPh SO_Two                A2   CH_TwoSOPh SO_Two                A2   CH_TwoSO_TwoPh SO_Two                A2   CH_TwoCOPh SO_Two                A2   CH_TwoCO_TwoPh SO_Two                A2   CH_Two(2-thienyl) SO_Two                A2   CH_Two(2-Phil) SO_Two                A2   CH_Two(3-Phil) SO_Two                A2   CH_Two(4-Phil) SO_Two                A2   4-Cl-Ph O A3   4-Cl-Ph S A3   4-Me-Ph NMe A3   2-Cl-Ph SO A3   4-Cl-Ph SO_Two                A3   4-Cl-Ph O A4   4-Cl-Ph S A4   4-Me-Ph NMe A4   2-Cl-Ph SO A4   4-Cl-Ph SO_Two                A4   4-Cl-Ph O A5   4-Cl-Ph O A6   4-Cl-Ph S A6   4-Cl-Ph O A7   4-Cl-Ph S A8   4-Me-Ph NMe A9   4-Cl-Ph SO_Two                A9    Ph O A10   2-Cl-Ph O A10   3-Cl-Ph O A10   4-Cl-Ph O A10   2,3-Cl_Two-Ph O A10   2,4-Cl_Two-Ph O A10   2,5-Cl_Two-Ph O A10   2,6-Cl_Two-Ph O A10   2,4,6-Cl_Three-Ph O A10   2-Br-Ph O A10   3-Br-Ph O A10   4-Br-Ph O A10   2,3-Br_Two-Ph O A10   2,4-Br_Two-Ph O A10   2,5-Br_Two-Ph O A10   2,6-Br_Two-Ph O A10   2-F-Ph O A10   3-F-Ph O A10   4-F-Ph O A10   2,3-F_Two-Ph O A10   2,4-F_Two-Ph O A10   2,5-F_Two-Ph O A10   2,6-F_Two-Ph O A10   2-Me-Ph O A10   3-Me-Ph O A10   4-Me-Ph O A10   2,3-Me_Two-Ph O A10   2,4-Me_Two-Ph O A10   2,5-Me_Two-Ph O A10   2,6-Me_Two-Ph O A10   4-nBu-Ph O A10   4-tBu-Ph O A10   4-Phenyl-Ph O A10   4-allyl-Ph O A10   2-fluoroalkyl-Ph O A10   2-CF_Three-Ph O A10   3-CF_Three-Ph O A10   4-CF_Three-Ph O A10   2-cPr-Ph O A10   3-cPr-Ph O A10   4-cPr-Ph O A10   4-cHex-Ph O A10   2-OMe-Ph O A10   3-OMe-Ph O A10   4-OMe-Ph O A10   4-nBuO-Ph O A10   4-Phenyloxy-Ph O A10   4-allyloxy-Ph O A10   2-fluoroalkyloxy-Ph O A10   2-OCF_Three-Ph O A10   3-OCF_Three-Ph O A10   4-OCF_Three-Ph O A10   4-hexyl-Ph O A10   2-SMe-Ph O A10   3-SMe-Ph O A10   4-SMe-Ph O A10   4-SOMe-Ph O A10   4-SO_TwoMe-Ph O A10   4-SCF_Three-Ph O A10   4-SOCF_Three-Ph O A10   4-SO_TwoCF_Three-Ph O A10   4-NO_Two-Ph O A10   4-CN-Ph O A10   4-NMe_Two-Ph O A10   4-phenoxy-Ph               O A10   4-CO_TwoMe-Ph O A10   4-COMe-Ph      O A10   4-Hensoil-Ph             O A10   4-Ph-Ph                  O A10   4-Phenyl-Ph              O A10   4-thienyl-Ph                O A10   2-naphthyl                   O A10   3-naphthyl                   O A10   2-thienyl                   O A10   3-thienyl                   O A10   2-furil                   O A10   3-furil                    O A10   2-hydroxyl                  O A10   3-hydroxyl                  O A10   2-oxasodilyl                O A10   4-oxasopril                O A10   5-oxasopril                O A10   3-isoxazoduryl               O A10   4-isoxazoduryl               O A10   5-isoxazoduryl               O A10   2-thiazole                 O A10   4-thiazole                 O A10   5-thiazolyl                 O A10   3-isothiazole               O A10   4-isothiazodyl               O A10   5-isothiazole               O A10   3-Hydrazolyl                O A10   4-Hyperazole                O A10   5-Hydrazole                O A10   2-Imitation Soril               O A10   4-Imitation Soril               O A10   5-Imitation Soril               O A10   1,3,4-oxathiazol-2-yl    O A10   1,2,4-oxathiazol-3-yl    O A10   1,2,4-oxathiazol-5-yl    O A10   1,3,4-thiazolazole-2-yl     O A10  5-Me-1,3,4-thiazazole-2-yl O A10   1,2,4-thiazolazole-3-yl     O A10   1,2,4-thiazolazole-5-yl     O A10   1,2,4-triazol-3-yl       O A10   1,2,4-triazole-5-yl       O A10   1,2,3-thiazolazole-4-yl     O A10   1,2,3-thiazolazole-5-yl     O A10   1,2,3-triazole-4-yl       O A10   1,2,3-triazole-5-yl       O A10   1,2,3,4-tetrasole-5-yl     O A10   2-Piryl O A10   5-Me-Puridine-2-yl O A10   5-Et-Puridine-2-yl O A10   5-NO_Two-Porcy-2-yl O A10   5-CF_Three-Porcy-2-yl O A10   3-Piryl O A10   4-Philly O A10   2-Primidinyl O A10   4-CF_Three-Hypermicin-2-yl O A10   4-Primidinyl O A10   5-Primidinyl O A10   2-Pirazine O A10   3-Horitacinil O A10   4-Pyritacinil O A10   1,3,5-triashidin-2-yl        O A10   1,2,4-triashidin-3-yl        O A10   1,2,4-triazine-5-yl        O A10   1,2,4-triazine-6-yl        O A10   2-Hensooxaoxalyl O A10   2-benzothiazole O A10   2-benzene immobilizer O A10   3-Intersolyl O A10   2-intryl O A10   3-intryl O A10   3-benzeneisoxazolyl O A10   3-Hensone isothiazolyl O A10   4-Hensone trisoaryl O A10   4-Hensooxaoxaril O A10   4-Hensothiazole O A10   2-quinolyl O A10   3-quinolyl O A10   4-quinolyl O A10   5-quinolyl O A10   6-quinolyl O A10   7-quinolyl O A10   8-quinolyl O A10   1-isoquinolyl O A10   3-isoquinolyl O A10   4-isoquinolyl O A10   5-isoquinolyl O A10   6-isoquinolyl O A10   7-isoquinolyl O A10   8-isoquinolyl O A10   2-quinoxalinyl O A10   5-quinoxalinyl O A10   6-quinoxalinyl O A10   1-phthalacidinyl O A10   5-phthalacidinyl O A10   6-phthalacidinyl O A10   3-cinnolinyl O A10   4-cinnolinyl O A10   5-cinnolinyl O A10   6-cinnolinyl O A10   7-cinnolinyl O A10   8-cinnolinyl O A10   2-Quinazoperinyl O A10   4-Quinazoperinyl O A10   5-Quinazoperinyl O A10   6-Quinazoperinyl O A10   7-Quinazoperinyl O A10   8-Quinazoperinyl O A10    Ph S A10   2-Cl-Ph S A10   3-Cl-Ph S A10   4-Cl-Ph S A10   2,3-Cl_Two-Ph S A10   2,4-Cl_Two-Ph S A10   2,5-Cl_Two-Ph S A10   2,6-Cl_Two-Ph S A10   2,4,6-Cl_Three-Ph S A10   2-Br-Ph S A10   3-Br-Ph S A10   4-Br-Ph S A10   2,3-Br_Two-Ph S A10   2,4-Br_Two-Ph S A10   2,5-Br_Two-Ph S A10   2,6-Br_Two-Ph S A10   2-F-Ph S A10   3-F-Ph S A10   4-F-Ph S A10   2,3-F_Two-Ph S A10   2,4-F_Two-Ph S A10   2,5-F_Two-Ph S A10   2,6-F_Two-Ph S A10   2-Me-Ph S A10   3-Me-Ph S A10   4-Me-Ph S A10   2,3-Me_Two-Ph S A10   2,4-Me_Two-Ph S A10   2,5-Me_Two-Ph S A10   2,6-Me_Two-Ph S A10   4-nBu-Ph S A10   4-tBu-Ph S A10   4-Phenyl-Ph S A10   4-allyl-Ph S A10   2-fluoroalkyl-Ph S A10   2-CF_Three-Ph S A10   3-CF_Three-Ph S A10   4-CF_Three-Ph S A10   2-cPr-Ph S A10   3-cPr-Ph S A10   4-cPr-Ph S A10   4-cHex-Ph S A10   2-OMe-Ph S A10   3-OMe-Ph S A10   4-OMe-Ph S A10   4-nBuO-Ph S A10   4-Phenyloxy-Ph S A10   4-allyloxy-Ph S A10   2-fluoroalkyloxy-Ph S A10   2-OCF_Three-Ph S A10   3-OCF_Three-Ph S A10   4-OCF_Three-Ph S A10   4-Hensyl-Ph S A10   2-SMe-Ph S A10   3-SMe-Ph S A10   4-SMe-Ph S A10   4-SOMe-Ph S A10   4-SO_TwoMe-Ph S A10   4-SCF_Three-Ph S A10   4-SOCF_Three-Ph S A10   4-SO_TwoCF_Three-Ph S A10   4-NO_Two-Ph S A10   4-CN-Ph S A10   4-NMe_Two-Ph S A10   4-phenoxy-Ph               S A10   4-CO_TwoMe-Ph S A10   4-COMe-Ph      S A10   4-Hensoil-Ph             S A10   4-Ph-Ph                  S A10   4-Phenyl-Ph              S A10   4-thienyl-Ph                S A10   2-naphthyl                   S A10   3-naphthyl                   S A10   2-thienyl                   S A10   3-thienyl                   S A10   2-furil                   S A10   3-furil                    S A10   2-hydroxyl                  S A10   3-hydroxyl                  S A10   2-oxasodilyl                S A10   4-oxasopril                S A10   5-oxasopril                S A10   3-isoxazoduryl               S A10   4-isoxazoduryl               S A10   5-isoxazoduryl               S A10   2-thiazole                 S A10   4-thiazole                 S A10   5-thiazolyl                 S A10   3-isothiazole               S A10   4-isothiazodyl               S A10   5-isothiazole               S A10   3-Hydrazolyl                S A10   4-Hyperazole                S A10   5-Hydrazole                S A10   2-Imitation Soril               S A10   4-Imitation Soril               S A10   5-Imitation Soril               S A10   1,3,4-oxathiazol-2-yl    S A10   1,2,4-oxathiazol-3-yl    S A10   1,2,4-oxathiazol-5-yl    S A10   1,3,4-thiathiazol-2-yl-2-yl     S A10  5-Me-1,3,4-thiadiazol-2-yl S A10   1,2,4-thiathiazol-3-yl-3-yl     S A10   1,2,4-thiazolazole-5-yl     S A10   1,2,4-triazol-3-yl-3-yl       S A10   1,2,4-triazol-5-yl       S A10   1,2,3-thiashiasol-4-yl     S A10   1,2,3-thiazolazole-5-yl     S A10   1,2,3-triazol-4-yl       S A10   1,2,3-triazole-5-yl       S A10   1,2,3,4-tetrasole-5-yl     S A10   2-Peel S A10   5-Me-Puridine-2-yl S A10   5-Et-Puridine-2-yl S A10   5-NO_Two-Pulse-2-yl S A10   5-CF_Three-Pulse-2-yl S A10   3-Primary S A10   4-Peircil S A10   2-Primidinyl S A10   4-CF_Three-Hypermicin-2-yl S A10   4-Primidinyl S A10   5-Primidinyl S A10   2-Pirazinil S A10   3-Horitacinil S A10   4-Hypercinyl S A10   1,3,5-triashidin-2-yl        S A10   1,2,4-triashidin-3-yl        S A10   1,2,4-triazine-5-yl        S A10   1,2,4-triazine-6-yl        S A10   2-Hensooxaxoryl S A10   2-benzothiazole S A10   2-bender immobilizer S A10   3-Intersolyl S A10   2-intryl S A10   3-intryl S A10   3-benzeneisoxazole S A10   3-Hensone isothiazole S A10   4-Henson triazole S A10   4-Hensooxaoxaril S A10   4-Hensothi assril S A10   2-quinolyl S A10   3-quinolyl S A10   4-quinolyl S A10   5-quinolyl S A10   6-quinolyl S A10   7-quinolyl S A10   8-quinolyl S A10   1-isoquinolyl S A10   3-isoquinolyl S A10   4-isoquinolyl S A10   5-isoquinolyl S A10   6-isoquinolyl S A10   7-isoquinolyl S A10   8-isoquinolyl S A10   2-quinoxalinyl S A10   5-quinoxalinyl S A10   6-quinoxalinyl S A10   1-phthalacidinyl S A10   5-phthalacidinyl S A10   6-phthalacidinyl S A10   3-cinnolinyl S A10   4-cinnolinyl S A10   5-cinnolinyl S A10   6-cinnolinyl S A10   7-cinnolinyl S A10   8-cinnolinyl S A10   2-Quinazoperinyl S A10   4-Quinazoperinyl S A10   5-Quinazoperinyl S A10   6-Quinazoperinyl S A10   7-Quinazoperinyl S A10   8-Quinazoperinyl S A10    Ph NH A10    Ph NMe A10   2-Cl-Ph NMe A10   3-Cl-Ph NMe A10   4-Cl-Ph NMe A10   2,3-Cl_Two-Ph NMe A10   2,4-Cl_Two-Ph NMe A10   2,4,6-Cl_Three-Ph NMe A10   2-Br-Ph NMe A10   4-F-Ph NMe A10   2,6-F_Two-Ph NMe A10   2-Me-Ph NMe A10   3-Me-Ph NMe A10   4-Me-Ph NMe A10   2,4-Me_Two-Ph NMe A10   4-nBu-Ph NMe A10   4-tBu-Ph NMe A10   4-Phenyl-Ph NMe A10   4-allyl-Ph NMe A10   2-fluoroalkyl-Ph NMe A10   2-CF_Three-Ph NMe A10   3-CF_Three-Ph NMe A10   4-CF_Three-Ph NMe A10   4-cPr-Ph NMe A10   4-cHex-Ph NMe A10   2-OMe-Ph NMe A10   3-OMe-Ph NMe A10   4-OMe-Ph NMe A10   4-nBuO-Ph NMe A10   4-Phenyloxy-Ph NMe A10   4-allyloxy-Ph NMe A10   2-fluoroalkyloxy-Ph NMe A10   2-OCF_Three-Ph NMe A10   3-OCF_Three-Ph NMe A10   4-OCF_Three-Ph NMe A10   2-SMe-Ph NMe A10   3-SMe-Ph NMe A10   4-SMe-Ph NMe A10   4-SOMe-Ph NMe A10   4-SO_TwoMe-Ph NMe A10   4-SCF_Three-Ph NMe A10   4-SOCF_Three-Ph NMe A10   4-SO_TwoCF_Three-Ph NMe A10   4-NO_Two-Ph NMe A10   4-CN-Ph NMe A10   4-NMe_Two-Ph NMe A10   4-phenoxy-Ph               NMe A10   4-CO_TwoMe-Ph NMe A10   4-COMe-Ph      NMe A10   4-Hensoil-Ph             NMe A10   4-Ph-Ph                  NMe A10   4-Phenyl-Ph              NMe A10   4-thienyl-Ph                NMe A10   2-naphthyl                   NMe A10   3-naphthyl                   NMe A10   2-thienyl                   NMe A10   3-thienyl                   NMe A10   2-furil                   NMe A10   3-furil                    NMe A10   2-hydroxyl                  NMe A10   3-hydroxyl                  NMe A10   2-oxasodilyl                NMe A10   4-oxasopril                NMe A10   5-oxasopril                NMe A10   3-isoxazoduryl               NMe A10   4-isoxazoduryl               NMe A10   5-isoxazoduryl               NMe A10   2-thiazole                 NMe A10   4-thiazole                 NMe A10   5-thiazolyl                 NMe A10   3-isothiazole               NMe A10   4-isothiazodyl               NMe A10   5-isothiazole               NMe A10   3-Hydrazolyl                NMe A10   4-Hyperazole                NMe A10   5-Hydrazole                NMe A10   2-Imitation Soril               NMe A10   4-Imitation Soril               NMe A10   5-Imitation Soril               NMe A10   1,3,4-oxathiazol-2-yl    NMe A10   1,2,4-oxathiazol-3-yl    NMe A10   1,2,4-oxathiazol-5-yl    NMe A10   1,3,4-thiathiazol-2-yl-2-yl     NMe A10  5-Me-1,3,4-thiadiazol-2-yl NMe A10   1,2,4-thiathiazol-3-yl-3-yl     NMe A10   1,2,4-thiazolazole-5-yl     NMe A10   1,2,4-triazol-3-yl-3-yl       NMe A10   1,2,4-triazol-5-yl       NMe A10   1,2,3-thiashiasol-4-yl     NMe A10   1,2,3-thiazolazole-5-yl     NMe A10   1,2,3-triazol-4-yl       NMe A10   1,2,3-triazole-5-yl       NMe A10   1,2,3,4-tetrasole-5-yl     NMe A10   2-Primary NMe A10   3-Primary NMe A10   4-Primary NMe A10   2-Primidinyl NMe A10   2-Pirazine NMe A10   3-Hypercinnil NMe A10   1,3,5-triashidin-2-yl        NMe A10   1,2,4-triashidin-3-yl        NMe A10   1,2,4-triazine-5-yl        NMe A10   1,2,4-triazine-6-yl        NMe A10   2-Hensooxaoxaril NMe A10   2-benzothiazole NMe A10   2-benzene immobilizer NMe A10   3-Intersolor NMe A10   2-intyryl NMe A10   3-intyryl NMe A10   3-benzeneisoxazolyl NMe A10   3-Hensone isothiazole NMe A10   4-Hensotriazole NMe A10   4-Hensooxaoxaril NMe A10   4-Hensothiazole NMe A10   2-quinolyl NMe A10   1-isoquinolyl NMe A10   2-quinoxalinyl NMe A10   1-phthalacidinyl NMe A10   3-cinnolinyl NMe A10   2-Quinazoperinyl NMe A10    Ph SO A10   2-Cl-Ph SO A10   3-Cl-Ph SO A10   4-Cl-Ph SO A10   2,3-Cl_Two-Ph SO A10   2,4-Cl_Two-Ph SO A10   2,4,6-Cl_Three-Ph SO A10   2-Br-Ph SO A10   4-F-Ph SO A10   2,6-F_Two-Ph SO A10   2-Me-Ph SO A10   3-Me-Ph SO A10   4-Me-Ph SO A10   2,4-Me_Two-Ph SO A10   4-nBu-Ph SO A10   4-tBu-Ph SO A10   4-Phenyl-Ph SO A10   4-allyl-Ph SO A10   2-fluoroalkyl-Ph SO A10   2-CF_Three-Ph SO A10   3-CF_Three-Ph SO A10   4-CF_Three-Ph SO A10   4-cPr-Ph SO A10   4-cHex-Ph SO A10   2-OMe-Ph SO A10   3-OMe-Ph SO A10   4-OMe-Ph SO A10   4-nBuO-Ph SO A10   4-Phenyloxy-Ph SO A10   4-allyloxy-Ph SO A10   2-fluoroalkyloxy-Ph SO A10   2-OCF_Three-Ph SO A10   3-OCF_Three-Ph SO A10   4-OCF_Three-Ph SO A10   2-SMe-Ph SO A10   3-SMe-Ph SO A10   4-SMe-Ph SO A10   4-SOMe-Ph SO A10   4-SO_TwoMe-Ph SO A10   4-SCF_Three-Ph SO A10   4-SOCF_Three-Ph SO A10   4-SO_TwoCF_Three-Ph SO A10   4-NO_Two-Ph SO A10   4-CN-Ph SO A10   4-NMe_Two-Ph SO A10   4-phenoxy-Ph               SO A10   4-CO_TwoMe-Ph SO A10   4-COMe-Ph      SO A10   4-Hensoil-Ph             SO A10   4-Ph-Ph                  SO A10   4-Phenyl-Ph              SO A10   4-thienyl-Ph                SO A10   2-naphthyl                   SO A10   3-naphthyl                   SO A10   2-thienyl                   SO A10   3-thienyl                   SO A10   2-furil                   SO A10   3-furil                    SO A10   2-hydroxyl                  SO A10   3-hydroxyl                  SO A10   2-oxasodilyl                SO A10   4-oxasopril                SO A10   5-oxasopril                SO A10   3-isoxazoduryl               SO A10   4-isoxazoduryl               SO A10   5-isoxazoduryl               SO A10   2-thiazole                 SO A10   4-thiazole                 SO A10   5-thiazolyl                 SO A10   3-isothiazole               SO A10   4-isothiazodyl               SO A10   5-isothiazole               SO A10   3-Hydrazolyl                SO A10   4-Hyperazole                SO A10   5-Hydrazole                SO A10   2-Imitation Soril               SO A10   4-Imitation Soril               SO A10   5-Imitation Soril               SO A10   1,3,4-oxathiazol-2-yl    SO A10   1,2,4-oxathiazol-3-yl    SO A10   1,2,4-oxathiazol-5-yl    SO A10   1,3,4-thiathiazol-2-yl-2-yl     SO A10  5-Me-1,3,4-thiathiazol-2-yl SO A10   1,2,4-thiathiazol-3-yl-3-yl     SO A10   1,2,4-thiazolazole-5-yl     SO A10   1,2,4-triazol-3-yl-3-yl       SO A10   1,2,4-triazol-5-yl       SO A10   1,2,3-thiashiasol-4-yl     SO A10   1,2,3-thiazolazole-5-yl     SO A10   1,2,3-triazol-4-yl       SO A10   1,2,3-triazole-5-yl       SO A10   1,2,3,4-tetrasole-5-yl     SO A10   2-Prior SO A10   3-Prior SO A10   4-Prior SO A10   2-Pyrimidinil SO A10   2-Pirazine SO A10   3-Hyperthinyl SO A10   1,3,5-triashidin-2-yl        SO A10   1,2,4-triashidin-3-yl        SO A10   1,2,4-triazine-5-yl        SO A10   1,2,4-triazine-6-yl        SO A10   2-Hensooxaoxaril SO A10   2-Hensothiazole SO A10   2-Hensor immobilizer SO A10   3-Intersolor SO A10   2-intryl SO A10   3-intril SO A10   3-Hensone isoxasorbyl SO A10   4-Hensotriazole SO A10   4-Hensooxaoxaril SO A10   4-Hensothi assiril SO A10   2-quinolyl SO A10   1-isoquinolyl SO A10   2-quinoxalinyl SO A10   1-phthalacidinyl SO A10   3-cinnolinyl SO A10   2-Quinazoperinyl SO A10   nBu SO A10   tBu SO A10   CH_Two-CH = CH_Two               SO A10   CH_Two-C≡CH SO A10   CF_Three                      SO A10   CF (CF_Three)_Two                 SO A10   CH_Two-CH = CF_Two               SO A10   cHex SO A10   CH_TwoOCH_Three                  SO A10   CH_TwoSCH_Three                  SO A10   CH_TwoPh SO A10   CH_Two(4-Cl-Ph) SO A10   CH_TwoOPh SO A10   CH_TwoSPh SO A10   CH_TwoSOPh SO A10   CH_TwoSO_TwoPh SO A10   CH_TwoCOPh SO A10   CH_TwoCO_TwoPh SO A10   CH_Two(2-thienyl) SO A10   CH_Two(2-Phil) SO A10   CH_Two(3-basic) SO A10   CH_Two(4-basic) SO A10    Ph SO_Two                A10   2-Cl-Ph SO_Two                A10   3-Cl-Ph SO_Two                A10   4-Cl-Ph SO_Two                A10   2,3-Cl_Two-Ph SO_Two                A10   2,4-Cl_Two-Ph SO_Two                A10   2,4,6-Cl_Three-Ph SO_Two                A10   2-Br-Ph SO_Two                A10   4-F-Ph SO_Two                A10   2,6-F_Two-Ph SO_Two                A10   2-Me-Ph SO_Two                A10   3-Me-Ph SO_Two                A10   4-Me-Ph SO_Two                A10   2,4-Me_Two-Ph SO_Two                A10   4-nBu-Ph SO_Two                A10   4-tBu-Ph SO_Two                A10   4-Phenyl-Ph SO_Two                A10   4-allyl-Ph SO_Two                A10   2-fluoroalkyl-Ph SO_Two                A10   2-CF_Three-Ph SO_Two                A10   3-CF_Three-Ph SO_Two                A10   4-CF_Three-Ph SO_Two                A10   4-cPr-Ph SO_Two                A10   4-cHex-Ph SO_Two                A10   2-OMe-Ph SO_Two                A10   3-OMe-Ph SO_Two                A10   4-OMe-Ph SO_Two                A10   4-nBuO-Ph SO_Two                A10   4-Phenyloxy-Ph SO_Two                A10   4-allyloxy-Ph SO_Two                A10   2-fluoroalkyloxy-Ph SO_Two                A10   2-OCF_Three-Ph SO_Two                A10   3-OCF_Three-Ph SO_Two                A10   4-OCF_Three-Ph SO_Two                A10   2-SMe-Ph SO_Two                A10   3-SMe-Ph SO_Two                A10   4-SMe-Ph SO_Two                A10   4-SOMe-Ph SO_Two                A10   4-SO_TwoMe-Ph SO_Two                A10   4-SCF_Three-Ph SO_Two                A10   4-SOCF_Three-Ph SO_Two                A10   4-SO_TwoCF_Three-Ph SO_Two                A10   4-NO_Two-Ph SO_Two                A10   4-CN-Ph SO_Two                A10   4-NMe_Two-Ph SO_Two                A10   4-phenoxy-Ph               SO_Two                A10   4-CO_TwoMe-Ph SO_Two                A10   4-COMe-Ph        SO_Two                A10   4-Hensoil-Ph             SO_Two                A10   4-Ph-Ph                  SO_Two                A10   4-Phenyl-Ph              SO_Two                A10   4-thienyl-Ph                SO_Two                A10   2-naphthyl                   SO_Two                A10   3-naphthyl                   SO_Two                A10   2-thienyl                   SO_Two                A10   3-thienyl                   SO_Two                A10   2-furil                   SO_Two                A10   3-furil                    SO_Two                A10   2-hydroxyl                  SO_Two                A10   3-hydroxyl                  SO_Two                A10   2-oxasodilyl                SO_Two                A10   4-oxasopril                SO_Two                A10   5-oxasopril                SO_Two                A10   3-isoxazoduryl               SO_Two                A10   4-isoxazoduryl               SO_Two                A10   5-isoxazoduryl               SO_Two                A10   2-thiazole                 SO_Two                A10   4-thiazole                 SO_Two                A10   5-thiazolyl                 SO_Two                A10   3-isothiazole               SO_Two                A10   4-isothiazodyl               SO_Two                A10   5-isothiazole               SO_Two                A10   3-Hydrazolyl                SO_Two                A10   4-Hyperazole                SO_Two                A10   5-Hydrazole                SO_Two                A10   2-Imitation Soril               SO_Two                A10   4-Imitation Soril               SO_Two                A10   5-Imitation Soril               SO_Two                A10   1,3,4-oxathiazol-2-yl    SO_Two                A10   1,2,4-oxathiazol-3-yl    SO_Two                A10   1,2,4-oxathiazol-5-yl    SO_Two                A10   1,3,4-thiathiazol-2-yl-2-yl     SO_Two                A10  5-Me-1,3,4-thiadiazol-2-yl SO_Two                A10   1,2,4-thiathiazol-3-yl-3-yl     SO_Two                A10   1,2,4-thiazolazole-5-yl     SO_Two                A10   1,2,4-triazol-3-yl-3-yl       SO_Two                A10   1,2,4-triazol-5-yl       SO_Two                A10   1,2,3-thiashiasol-4-yl     SO_Two                A10   1,2,3-thiazolazole-5-yl     SO_Two                A10   1,2,3-triazol-4-yl       SO_Two                A10   1,2,3-triazole-5-yl       SO_Two                A10   1,2,3,4-tetrasole-5-yl     SO_Two                A10   2-Philsil SO_Two                A10   3-Primary SO_Two                A10   4-Phil Sir_Two                A10   2-pyrimidinyl SO_Two                A10   2-Pyrazine SO_Two                A10   3-Horitacinil SO_Two                A10   1,3,5-triashidin-2-yl        SO_Two                A10   1,2,4-triashidin-3-yl        SO_Two                A10   1,2,4-triazine-5-yl        SO_Two                A10   1,2,4-triazine-6-yl        SO_Two                A10   2-Hensooxaoxaril SO_Two                A10   2-Hensothiazole SO_Two                A10   2-Hensor immobilizer SO_Two                A10   3-Intersolyl SO_Two                A10   2-intryl SO_Two                A10   3-intril SO_Two                A10   3-Hensone isoxasoryl SO_Two                A10   3-Hensone isothiazolyl SO_Two                A10   4-Hensotriazole SO_Two                A10   4-Hensooxaoxaril SO_Two                A10   4-Hensothiazole SO_Two                A10   2-quinolyl SO_Two                A10   1-isoquinolyl SO_Two                A10   2-quinoxalinyl SO_Two                A10   1-phthalacinyl SO_Two                A10   3-cinnolinyl SO_Two                A10   2-Quinazoperinyl SO_Two                A10   nBu SO_Two                A10   tBu SO_Two                A10   CH_Two-CH = CH_Two               SO_Two                A10   CH_Two-C≡CH SO_Two                A10   CF_Three                      SO_Two                A10   CF (CF_Three)_Two                 SO_Two                A10   CH_Two-CH = CF_Two               SO_Two                A10   cHex SO_Two                A10   CH_TwoOCH_Three                  SO_Two                A10   CH_TwoSCH_Three                  SO_Two                A10   CH_TwoPh SO_Two                A10   CH_Two(4-Cl-Ph) SO_Two                A10   CH_TwoOPh SO_Two                A10   CH_TwoSPh SO_Two                A10   CH_TwoSOPh SO_Two                A10   CH_TwoSO_TwoPh SO_Two                A10   CH_TwoCOPh SO_Two                A10   CH_TwoCO_TwoPh SO_Two                A10   CH_Two(2-thienyl) SO_Two                A10   CH_Two(2-Phil) SO_Two                A10   CH_Two(3-Phil) SO_Two                A10   CH_Two(4-Phil) SO_Two                A10   4-Cl-Ph O A11   4-Cl-Ph S A11   4-Me-Ph NMe A11   2-Cl-Ph SO A11   4-Cl-Ph SO_Two                A11   4-Cl-Ph O A12   4-Cl-Ph SO_Two                A12   4-Cl-Ph O A13   4-Cl-Ph S A13   4-Cl-Ph O A14   4-Cl-Ph SO_Two                A14   4-Cl-Ph O A15   4-Cl-Ph S A15   4-Cl-Ph O A16   4-Cl-Ph SO_Two                A16   4-Cl-Ph O A17   4-Cl-Ph S A17   4-Cl-Ph O A18   4-Cl-Ph SO_Two                A18   4-Cl-Ph O A19   4-Cl-Ph S A19   4-Cl-Ph O A20   4-Cl-Ph SO_Two                A21   4-Cl-Ph O A22   4-Cl-Ph S A23    Ph O A24   2-Cl-Ph O A24   3-Cl-Ph O A24   4-Cl-Ph O A24   2,3-Cl_Two-Ph O A24   2,4-Cl_Two-Ph O A24   2,5-Cl_Two-Ph O A24   2,6-Cl_Two-Ph O A24   2,4,6-Cl_Three-Ph O A24   2-Br-Ph O A24   3-Br-Ph O A24   4-Br-Ph O A24   2,3-Br_Two-Ph O A24   2,4-Br_Two-Ph O A24   2,5-Br_Two-Ph O A24   2,6-Br_Two-Ph O A24   2-F-Ph O A24   3-F-Ph O A24   4-F-Ph O A24   2,3-F_Two-Ph O A24   2,4-F_Two-Ph O A24   2,5-F_Two-Ph O A24   2,6-F_Two-Ph O A24   2-Me-Ph O A24   3-Me-Ph O A24   4-Me-Ph O A24   2,3-Me_Two-Ph O A24   2,4-Me_Two-Ph O A24   2,5-Me_Two-Ph O A24   2,6-Me_Two-Ph O A24   4-nBu-Ph O A24   4-tBu-Ph O A24   2-CF_Three-Ph O A24   3-CF_Three-Ph O A24   4-CF_Three-Ph O A24   4-cHex-Ph O A24   3-OMe-Ph O A24   4-nBuO-Ph O A24   2-OCF_Three-Ph O A24   3-OCF_Three-Ph O A24   4-OCF_Three-Ph O A24   2-SMe-Ph O A24   4-SMe-Ph O A24   4-SO_TwoMe-Ph O A24   4-SO_TwoCF_Three-Ph O A24   4-NO_Two-Ph O A24   4-phenoxy-Ph               O A24   4-CO_TwoMe-Ph O A24   2-naphthyl                   O A24   3-naphthyl                   O A24   3-thienyl                   O A24   2-oxasodilyl                O A24   3-Hydrazolyl                O A24   5-Hydrazole                O A24   1,3,4-oxathiazol-2-yl    O A24   1,3,4-thiathiazol-2-yl-2-yl     O A24  5-Me-1,3,4-thiadiazol-2-yl O A24   5-Me-Puridine-2-yl O A24   5-Et-Puridine-2-yl O A24   5-NO_Two-Porcy-2-yl O A24   5-CF_Three-Porcy-2-yl O A24   3-Piryl O A24   4-Philly O O24   2-Primidinyl O A24   4-CF_Three-Primishin-2-yl O A24   2-Hensooxaoxaril O A24   2-benzothiasorbyl O A24   3-intersolyl O A24   2-intryl O A24   3-intryl O A24   2-quinolyl O A24   3-quinolyl O A24   1-isoquinolyl O A24   3-isoquinolyl O A24    Ph S A24   2-Cl-Ph S A24   3-Cl-Ph S A24   4-Cl-Ph S A24   2,3-Cl_Two-Ph S A24   2,4-Cl_Two-Ph S A24   2,5-Cl_Two-Ph S A24   2,6-Cl_Two-Ph S A24   2,4,6-Cl_Three-Ph S A24   2-Br-Ph S A24   3-Br-Ph S A24   4-Br-Ph S A24   2,3-Br_Two-Ph S A24   2,4-Br_Two-Ph S A24   2,5-Br_Two-Ph S A24   2,6-Br_Two-Ph S A24   2-F-Ph S A24   3-F-Ph S A24   4-F-Ph S A24   2,3-F_Two-Ph S A24   2,4-F_Two-Ph S A24   2,5-F_Two-Ph S A24   2,6-F_Two-Ph S A24   2-Me-Ph S A24   3-Me-Ph S A24   4-Me-Ph S A24   2,3-Me_Two-Ph S A24   2,4-Me_Two-Ph S A24   2,5-Me_Two-Ph S A24   2,6-Me_Two-Ph S A24   4-nBu-Ph S A24   4-tBu-Ph S A24   2-CF_Three-Ph S A24   3-CF_Three-Ph S A24   4-CF_Three-Ph S A24   2-OMe-Ph S A24   4-nBuO-Ph S A24   4-Phenyloxy-Ph S A24   4-allyloxy-Ph S A24   2-OCF_Three-Ph S A24   2-Peel S A24   5-Me-Puridine-2-yl S A24   5-Et-Puridine-2-yl S A24   5-NO_Two-Pulse-2-yl S A24   5-CF_Three-Pulse-2-yl S A24   3-Phil S-A24   2-Primidinyl S A24   4-CF_Three-Hypermicin-2-yl S A24   2-Hensone oxasoryl S A24   2-Hensothiazolyl S A24   2-quinolyl S A24    Ph NH A24    Ph NMe A24   2-Cl-Ph NMe A24   3-Cl-Ph NMe A24   4-Cl-Ph NMe A24   2,4-Cl_Two-Ph NMe A24   2-Br-Ph NMe A24   4-F-Ph NMe A24   2,6-F_Two-Ph NMe A24   2-Me-Ph NMe A24   3-Me-Ph NMe A24   4-Me-Ph NMe A24   4-nBu-Ph NMe A24   4-tBu-Ph NMe A24   2-CF_Three-Ph NMe A24   4-CF_Three-Ph NMe A24   2-OMe-Ph NMe A24   3-OMe-Ph NMe A24   4-nBuO-Ph NMe A24   2-OCF_Three-Ph NMe A24   3-OCF_Three-Ph NMe A24   4-OCF_Three-Ph NMe A24   4-CN-Ph NMe A24   4-phenoxy-Ph               NMe A24   4-CO_TwoMe-Ph NMe A24   5-Hydrazole                NMe A24   1,3,4-thiathiazol-2-yl-2-yl     NMe A24  5-Me-1,3,4-thiadiazol-2-yl NMe A24   2-Primary NMe A24   2-Primidinyl NMe A24   2-Hensooxaoxaril NMe A24   2-Hensothiazole NMe A24   2-quinolyl NMe A24    Ph SO A24   2-Cl-Ph SO A24   3-Cl-Ph SO A24   4-Cl-Ph SO A24   2,4-Cl_Two-Ph SO A24   2,4,6-Cl_Three-Ph SO A24   2-Br-Ph SO A24   4-F-Ph SO A24   2,6-F_Two-Ph SO A24   2-Me-Ph SO A24   3-Me-Ph SO A24   4-Me-Ph SO A24   2,4-Me_Two-Ph SO A24   4-nBu-Ph SO A24   4-tBu-Ph SO A24   2-CF_Three-Ph SO A24   3-CF_Three-Ph SO A24   4-CF_Three-Ph SO A24   4-cHex-Ph SO A24   3-OMe-Ph SO A24   4-nBuO-Ph SO A24   2-OCF_Three-Ph SO A24   3-OCF_Three-Ph SO A24   4-OCF_Three-Ph SO A24   4-NO_Two-Ph SO A24   4-CN-Ph SO A24   4-phenoxy-Ph               SO A24   4-CO_TwoMe-Ph SO A24   2-naphthyl                   SO A24   3-naphthyl                   SO A24   2-thiazole                 SO A24   5-Hydrazole                SO A24   1,3,4-oxathiazol-2-yl    SO A24   1,3,4-thiathiazol-2-yl-2-yl     SO A24  5-Me-1,3,4-thiathiazol-2-yl SO A24   2-Prior SO A24   2-Primidinyl SO A24   2-Hensooxaoxaril SO A24   2-Hensothiazole SO A24   2-quinolyl SO A24   nBu SO A24   tBu SO A24   CH_Two-CH = CH_Two               SO A24   CH_Two-C≡CH SO A24   CF (CF_Three)_Two                 SO A24   CH_Two-CH = CF_Two               SO A24   CH_TwoPh SO A24   CH_Two(4-Cl-Ph) SO A24    Ph SO_Two                A24   2-Cl-Ph SO_Two                A24   3-Cl-Ph SO_Two                A24   4-Cl-Ph SO_Two                A24   2,3-Cl_Two-Ph SO_Two                A24   2,4-Cl_Two-Ph SO_Two                A24   2,4,6-Cl_Three-Ph SO_Two                A24   2-Br-Ph SO_Two                A24   4-F-Ph SO_Two                A24   2,6-F_Two-Ph SO_Two                A24   2-Me-Ph SO_Two                A24   3-Me-Ph SO_Two                A24   4-Me-Ph SO_Two                A24   2,4-Me_Two-Ph SO_Two                A24   4-nBu-Ph SO_Two                A24   4-tBu-Ph SO_Two                A24   2-CF_Three-Ph SO_Two                A24   3-CF_Three-Ph SO_Two                A24   4-CF_Three-Ph SO_Two                A24   4-cHex-Ph SO_Two                A24   2-OMe-Ph SO_Two                A24   3-OMe-Ph SO_Two                A24   4-OMe-Ph SO_Two                A24   4-nBuO-Ph SO_Two                A24   2-OCF_Three-Ph SO_Two                A24   3-OCF_Three-Ph SO_Two                A24   4-OCF_Three-Ph SO_Two                A24   4-SO_TwoMe-Ph SO_Two                A24   4-SO_TwoCF_Three-Ph SO_Two                A24   4-NO_Two-Ph SO_Two                A24   4-CN-Ph SO_Two                A24   4-phenoxy-Ph               SO_Two                A24   4-CO_TwoMe-Ph SO_Two                A24   4-Phenyl-Ph              SO_Two                A24   3-naphthyl                   SO_Two                A24   2-thiazole                 SO_Two                A24   3-Hydrazolyl                SO_Two                A24   1,3,4-oxathiazol-2-yl    SO_Two                A24   1,3,4-thiathiazol-2-yl-2-yl     SO_Two                A24  5-Me-1,3,4-thiadiazol-2-yl SO_Two                A24   2-Philsil SO_Two                A24   2-pyrimidinyl SO_Two                A24   2-Hensooxaoxaril SO_Two                A24   2-Hensothiazole SO_Two                A24   2-quinolyl SO_Two                A24   nBu SO_Two                A24   tBu SO_Two                A24   CH_Two-CH = CH_Two               SO_Two                A24   CH_Two-C≡CH SO_Two                A24   CF_Three                      SO_Two                A24   CF (CF_Three)_Two                 SO_Two                A24   CH_Two-CH = CF_Two               SO_Two                A24   cHex SO_Two                A24   CH_TwoPh SO_Two                A24   CH_Two(4-Cl-Ph) SO_Two                A24   CH_Two(2-thienyl) SO_Two                A24   CH_Two(2-Phil) SO_Two                A24   CH_Two(3-Phil) SO_Two                A24   CH_Two(4-Phil) SO_Two                A24    Ph O A25   2-Cl-Ph O A25   3-Cl-Ph O A25   4-Cl-Ph O A25   2,3-Cl_Two-Ph O A25   2,4-Cl_Two-Ph O A25   2,5-Cl_Two-Ph O A25   2,6-Cl_Two-Ph O A25   2,4,6-Cl_Three-Ph O A25   2-Br-Ph O A25   3-Br-Ph O A25   4-Br-Ph O A25   2,3-Br_Two-Ph O A25   2,4-Br_Two-Ph O A25   2,5-Br_Two-Ph O A25   2,6-Br_Two-Ph O A25   2-F-Ph O A25   3-F-Ph O A25   4-F-Ph O A25   2,3-F_Two-Ph O A25   2,4-F_Two-Ph O A25   2,5-F_Two-Ph O A25   2,6-F_Two-Ph O A25   2-Me-Ph O A25   3-Me-Ph O A25   4-Me-Ph O A25   2,3-Me_Two-Ph O A25   2,4-Me_Two-Ph O A25   2,5-Me_Two-Ph O A25   2,6-Me_Two-Ph O A25   4-nBu-Ph O A25   4-tBu-Ph O A25   2-CF_Three-Ph O A25   3-CF_Three-Ph O A25   4-CF_Three-Ph O A25   4-cHex-Ph O A25   3-OMe-Ph O A25   4-nBuO-Ph O A25   2-OCF_Three-Ph O A25   3-OCF_Three-Ph O A25   4-OCF_Three-Ph O A25   2-SMe-Ph O A25   4-SMe-Ph O A25   4-SO_TwoMe-Ph O A25   4-SO_TwoCF_Three-Ph O A25   4-NO_Two-Ph O A25   4-phenoxy-Ph               O A25   4-CO_TwoMe-Ph O A25   2-naphthyl                   O A25   3-naphthyl                   O A25   3-thienyl                   O A25   2-oxasodilyl                O A25   3-Hydrazolyl                O A25   5-Hydrazole                O A25   1,3,4-oxathiazol-2-yl    O A25   1,3,4-thiathiazol-2-yl-2-yl     O A25  5-Me-1,3,4-thiadiazol-2-yl O A25   5-Me-Puridine-2-yl O A25   5-Et-Puridine-2-yl O A25   5-NO_Two-Pulse-2-yl O A25   5-CF_Three-Pulse-2-yl O A25   3-Piryl O A25   4-Philly O O25   2-Primidinyl O A25   4-CF_Three-Hypermicin-2-yl O A25   2-Hensooxaoxaril O A25   2-benzothiazole O A25   3-Intersolyl O A25   2-intryl O A25   3-intryl O A25   2-quinolyl O A25   3-quinolyl O A25   1-isoquinolyl O A25   3-isoquinolyl O A25    Ph S A25   2-Cl-Ph S A25   3-Cl-Ph S A25   4-Cl-Ph S A25   2,3-Cl_Two-Ph S A25   2,4-Cl_Two-Ph S A25   2,5-Cl_Two-Ph S A25   2,6-Cl_Two-Ph S A25   2,4,6-Cl_Three-Ph S A25   2-Br-Ph S A25   3-Br-Ph S A25   4-Br-Ph S A25   2,3-Br_Two-Ph S A25   2,4-Br_Two-Ph S A25   2,5-Br_Two-Ph S A25   2,6-Br_Two-Ph S A25   2-F-Ph S A25   3-F-Ph S A25   4-F-Ph S A25   2,3-F_Two-Ph S A25   2,4-F_Two-Ph S A25   2,5-F_Two-Ph S A25   2,6-F_Two-Ph S A25   2-Me-Ph S A25   3-Me-Ph S A25   4-Me-Ph S A25   2,3-Me_Two-Ph S A25   2,4-Me_Two-Ph S A25   2,5-Me_Two-Ph S A25   2,6-Me_Two-Ph S A25   4-nBu-Ph S A25   4-tBu-Ph S A25   2-CF_Three-Ph S A25   3-CF_Three-Ph S A25   4-CF_Three-Ph S A25   2-OMe-Ph S A25   4-nBuO-Ph S A25   4-Phenyloxy-Ph S A25   4-allyloxy-Ph S A25   2-OCF_Three-Ph S A25   2-Peel S A25   5-Me-Puridine-2-yl S A25   5-Et-Puridine-2-yl S A25   5-NO_Two-Pulse-2-yl S A25   5-CF_Three-Pulse-2-yl S A25   3-Phil S-A25   2-Primidinyl S A25   4-CF_Three-Hypermicin-2-yl S A25   2-benzoxazole S A25   2-benzothiazole S A25   2-quinolyl S A25    Ph NH A25    Ph NMe A25   2-Cl-Ph NMe A25   3-Cl-Ph NMe A25   4-Cl-Ph NMe A25   2,4-Cl_Two-Ph NMe A25   2-Br-Ph NMe A25   4-F-Ph NMe A25   2,6-F_Two-Ph NMe A25   2-Me-Ph NMe A25   3-Me-Ph NMe A25   4-Me-Ph NMe A25   4-nBu-Ph NMe A25   4-tBu-Ph NMe A25   2-CF_Three-Ph NMe A25   4-CF_Three-Ph NMe A25   2-OMe-Ph NMe A25   3-OMe-Ph NMe A25   4-nBuO-Ph NMe A25   2-OCF_Three-Ph NMe A25   3-OCF_Three-Ph NMe A25   4-OCF_Three-Ph NMe A25   4-CN-Ph NMe A25   4-phenoxy-Ph               NMe A25   4-CO_TwoMe-Ph NMe A25   5-Hydrazole                NMe A25   1,3,4-thiathiazol-2-yl-2-yl     NMe A25  5-Me-1,3,4-thiadiazol-2-yl NMe A25   2-Phicle NMe A25   2-Primidinyl NMe A25   2-Hensooxaoxaril NMe A25   2-Hensothiazole NMe A25   2-quinolyl NMe A25    Ph SO A25   2-Cl-Ph SO A25   3-Cl-Ph SO A25   4-Cl-Ph SO A25   2,4-Cl_Two-Ph SO A25   2,4,6-Cl_Three-Ph SO A25   2-Br-Ph SO A25   4-F-Ph SO A25   2,6-F_Two-Ph SO A25   2-Me-Ph SO A25   3-Me-Ph SO A25   4-Me-Ph SO A25   2,4-Me_Two-Ph SO A25   4-nBu-Ph SO A25   4-tBu-Ph SO A25   2-CF_Three-Ph SO A25   3-CF_Three-Ph SO A25   4-CF_Three-Ph SO A25   4-cHex-Ph SO A25   3-OMe-Ph SO A25   4-nBuO-Ph SO A25   2-OCF_Three-Ph SO A25   3-OCF_Three-Ph SO A25   4-OCF_Three-Ph SO A25   4-NO_Two-Ph SO A25   4-CN-Ph SO A25   4-phenoxy-Ph               SO A25   4-CO_TwoMe-Ph SO A25   2-naphthyl                   SO A25   3-naphthyl                   SO A25   2-thiazole                 SO A25   5-Hydrazole                SO A25   1,3,4-oxathiazol-2-yl    SO A25   1,3,4-thiathiazol-2-yl-2-yl     SO A25  5-Me-1,3,4-thiathiazol-2-yl SO A25   2-Piryl SO A25   2-Pyrimidinil SO A25   2-Hensooxaoxaril SO A25   2-Hensothiazole SO A25   2-quinolyl SO A25   nBu SO A25   tBu SO A25   CH_Two-CH = CH_Two               SO A25   CH_Two-C≡CH SO A25   CF (CF_Three)_Two                 SO A25   CH_Two-CH = CF_Two               SO A25   CH_TwoPh SO A25   CH_Two(4-Cl-Ph) SO A25    Ph SO_Two                A25   2-Cl-Ph SO_Two                A25   3-Cl-Ph SO_Two                A25   4-Cl-Ph SO_Two                A25   2,3-Cl_Two-Ph SO_Two                A25   2,4-Cl_Two-Ph SO_Two                A25   2,4,6-Cl_Three-Ph SO_Two                A25   2-Br-Ph SO_Two                A25   4-F-Ph SO_Two                A25   2,6-F_Two-Ph SO_Two                A25   2-Me-Ph SO_Two                A25   3-Me-Ph SO_Two                A25   4-Me-Ph SO_Two                A25   2,4-Me_Two-Ph SO_Two                A25   4-nBu-Ph SO_Two                A25   4-tBu-Ph SO_Two                A25   2-CF_Three-Ph SO_Two                A25   3-CF_Three-Ph SO_Two                A25   4-CF_Three-Ph SO_Two                A25   4-cHex-Ph SO_Two                A25   2-OMe-Ph SO_Two                A25   3-OMe-Ph SO_Two                A25   4-OMe-Ph SO_Two                A25   4-nBuO-Ph SO_Two                A25   2-OCF_Three-Ph SO_Two                A25   3-OCF_Three-Ph SO_Two                A25   4-OCF_Three-Ph SO_Two                A25   4-SO_TwoMe-Ph SO_Two                A25   4-SO_TwoCF_Three-Ph SO_Two                A25   4-NO_Two-Ph SO_Two                A25   4-CN-Ph SO_Two                A25   4-phenoxy-Ph               SO_Two                A25   4-CO_TwoMe-Ph SO_Two                A25   4-Phenyl-Ph              SO_Two                A25   3-naphthyl                   SO_Two                A25   2-thiazole                 SO_Two                A25   3-Hydrazolyl                SO_Two                A25   1,3,4-oxathiazol-2-yl    SO_Two                A25   1,3,4-thiathiazol-2-yl-2-yl     SO_Two                A25  5-Me-1,3,4-thiadiazol-2-yl SO_Two                A25   2-Philsil SO_Two                A25   2-pyrimidinyl SO_Two                A25   2-Hensooxaoxaril SO_Two                A25   2-Hensothiazole SO_Two                A25   2-quinolyl SO_Two                A25   nBu SO_Two                A25   tBu SO_Two                A25   CH_Two-CH = CH_Two               SO_Two                A25   CH_Two-C≡CH SO_Two                A25   CF_Three                      SO_Two                A25   CF (CF_Three)_Two                 SO_Two                A25   CH_Two-CH = CF_Two               SO_Two                A25   cHex SO_Two                A25   CH_TwoPh SO_Two                A25   CH_Two(4-Cl-Ph) SO_Two                A25   CH_Two(2-thienyl) SO_Two                A25   CH_Two(2-Phil) SO_Two                A25   CH_Two(3-Phil) SO_Two                A25   CH_Two(4-Phil) SO_Two                A25   4-Cl-Ph O A26   4-Cl-Ph S A26   4-Cl-Ph O A27   4-Cl-Ph SO_Two                A28   4-Cl-Ph O A29   4-Cl-Ph S A30   4-Cl-Ph O A31   4-Cl-Ph S A31   4-Me-Ph NMe A31   2-Cl-Ph SO A31   4-Cl-Ph SO_Two                A31   4-Cl-Ph O A32   4-Cl-Ph S A32   4-Me-Ph NMe A32   2-Cl-Ph SO A32   4-Cl-Ph SO_Two                A32   4-Cl-Ph O A33   4-Cl-Ph S A34   4-Cl-Ph S A35   4-Cl-Ph O A36   4-Cl-Ph SO_Two                A37   4-Cl-Ph O A38   4-Cl-Ph S A39   4-Cl-Ph S A40   4-Cl-Ph O A41   4-Cl-Ph O A42   4-Cl-Ph S A42   4-Me-Ph NMe A42   2-Cl-Ph SO A42   4-Cl-Ph SO_Two                A42   4-Cl-Ph O A43   4-Cl-Ph S A44   4-Cl-Ph O A45   4-Cl-Ph S A45   4-Me-Ph NMe A45   2-Cl-Ph SO A45   4-Cl-Ph SO_Two                A45   4-Cl-Ph O A46   4-Cl-Ph S A46   4-Me-Ph NMe A46   2-Cl-Ph SO A46   4-Cl-Ph SO_Two                A46   4-Cl-Ph SO_Two                A47   4-Cl-Ph O A48   4-Cl-Ph S A49   4-Cl-Ph S A50   4-Cl-Ph O A51   4-Cl-Ph SO_Two                A52   4-Cl-Ph O A53   4-Cl-Ph S A54   4-Cl-Ph S A55   4-Cl-Ph O A56   4-Cl-Ph SO_Two                A57   4-Cl-Ph O A58   4-Cl-Ph S A59   4-Cl-Ph S A60   4-Cl-Ph O A61 ――――――――――――――――――――――――――

[Table 2]

[0310]

Embedded image

[0311]

Embedded image

[0312]

[Table 2] ――――――――――――――――――――――――――――――――― AB ―――――――――― ――――――――――――――――――――――――― A1 H A1 Me A1 CH ₂ OMe A1 SO ₂ Ph A1 COMe A1 COtBu A1 COiBu A1 COiPr A1 COPh A1 CO ₂ Me A1 CO ₂ Et A1 CO ₂ CH ₂ Ph A1 C (O) SMe A1 C (O) SEt A1 C (O) SPh A1 C (S) OEt A1 C (S) SEt A1 C (S) OPh A2 H A2 Me A2 CH ₂ OMe A2 SO ₂ Ph A2 COMe A2 COtBu A2 COiBu A2 COiPr A2 COPh A2 CO ₂ Me A2 CO ₂ Et A2 CO ₂ CH ₂ Ph A2 C (O) SMe A2 C (O) SEt A2 C (O) SPh A2 C (S) OEt A2 C (S) SEt A2 C (S) OPh A3 H A3 COtBu A4 H A4 COtBu A5 H A5 COtBu A6 H A6 COtBu A7 H A7 COtBu A8 H A8 COtBu A9 H A9 COtBu A10 H A10 Me A10 CH ₂ OMe A10 SO ₂ Ph A10 COMe A10 COtBu A10 COiBu A10 COiPr A10 COPh A10 CO ₂ Me A10 CO ₂ Et A10 CO ₂ CH ₂ Ph A10 C (O) SMe A10 C (O) SEt A10 C (O) SPh A10 C (S) OEt A10 C (S) SEt A10 C (S) OPh A11 H A11 COtBu A12 H A12 COtBu A13 H A13 COtBu A14 H A14 COtBu A15 H A15 COtBu A16 H A16 COtBu A17 H A17 COtBu A 18 H A18 COtBu A19 H A19 COtBu A20 H A20 COtBu A21 H A21 COtBu A22 H A22 COtBu A23 H A23 COtBu A24 H A24 Me A24 CH ₂ OMe A24 SO ₂ Ph A24 COMe A24 COtBu A24 COiBu A24 COiPr A24 COPh A24 CO ₂ Me A24 CO ₂ Et A24 CO ₂ CH ₂ Ph A24 C (O) SMe A24 C (O) SEt A24 C (O) SPh A24 C (S) OEt A24 C (S) SEt A24 C (S) OPh A25 H A25 Me A25 CH ₂ OMe A25 SO ₂ Ph A25 COMe A25 COtBu A25 COiBu A25 COiPr A25 COPh A25 CO ₂ Me A25 CO ₂ Et A25 CO ₂ CH ₂ Ph A25 C (O) SMe A25 C (O) SEt A25 C (O) SPh A25 C (S) OEt A25 C (S) SEt A25 C (S) OPh A26 H A26 COtBu A27 H A27 COtBu A28 H A28 COtBu A29 H A29 COtBu A30 H A30 COtBu A31 H A31 COtBu A32 H A32 COtBu A33 H A33 COtBu A34 H A34 COtBu A35 H A35 COtBu A36 H A36 COtBu A37 H A37 COtBu A38 H A38 COtBu A39 H A39 COtBu A40 H A40 COtBu A41 H A41 COtBu A42 H A42 COtBu A43 H A43 COtBu A44 H A44 COtBu A45 H A45 COtBu A46 COtBu A47 H A47 COtBu A48 H A48 COtBu A49 H A49 COtBu A50 H A50 COtBu A51 H A51 COtBu A52 H A52 COtBu A53 H A53 COtBu A54 H A54 COtBu A55 H A55 COtBu A56 H A56 COtBu A57 H A57 C OtBu A58 H A58 COtBu A59 H A59 COtBu A60 H A60 COtBu A61 H A61 COtBu ――――――――――――――――――――――――――――――――― -

In applying the compound of the present invention, it is usually mixed with an appropriate solid carrier or liquid carrier, and if necessary, a surfactant, a penetrant, a spreading agent, a thickener, a deicing agent,
Add a binder, an anti-caking agent, a disintegrant, an anti-decomposition agent, etc. to add a soluble concentrate, an emulsifia
ble concentrate), wettable powder, water soluble powder, water dispersible
ersible granule, water soluble granu
le), suspension concentrates, emulsions (co
ncentrated emulsion, suspoem
ulsion), microemulsion,
It can be put to practical use in preparations of any dosage form such as dustable powders, granules and gels. Further, from the viewpoint of labor saving and improvement of safety, the above-mentioned preparation of any dosage form can be provided by being enclosed in a water-soluble package.

Examples of the solid carrier include natural minerals such as quartz, kaolinite, pyrophyllite, sericite, talc, bentonite, acid clay, attapulgite, zeolite and diatomaceous earth, calcium carbonate, ammonium sulfate, sodium sulfate and potassium chloride. And the like, inorganic silicic acid and synthetic silicate.

As the liquid carrier, for example, ethylene glycol
Alcohols such as benzyl, propylene glycol and isopropanol; aromatic hydrocarbons such as xylene, alkylbenzene and alkylnaphthalene; ethers such as butyl cellosolve; ketones such as cyclohexanone;
Esters such as butyrolactone, N-methylpyrrolidone, acid amides such as N-octylpyrrolidone, soybean oil,
Vegetable oils such as rapeseed oil, cottonseed oil and castor oil, and water.

These solid and liquid carriers may be used alone or in combination of two or more.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl aryl ether, polyoxyethylene styrylphenyl ether, polyoxyethylene polyoxypropylene block copolymer, and polyoxyethylene. Nonionic surfactants such as fatty acid esters, sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters, alkyl sulfates, alkyl benzene sulfonates,
Lignin sulfonate, alkyl sulfosuccinate, naphthalene sulfonate, alkyl naphthalene sulfonate, salt of formalin condensate of naphthalene sulfonic acid, salt of formalin condensate of alkyl naphthalene sulfonic acid,
Anionic surfactants such as polyoxyethylene alkyl aryl ether sulfate and phosphate, polyoxyethylene styrylphenyl ether sulfate and phosphate, polycarboxylate and polystyrene sulfonate, alkylamine salt and alkyl4 And cationic surfactants such as quaternary ammonium salts and amphoteric surfactants such as amino acid type and betaine type.

The content of these surfactants is not particularly limited, but is preferably in the range of usually 0.05 to 20 parts by weight based on 100 parts by weight of the preparation of the present invention. These surfactants may be used alone or in combination of two or more.

When the compound of the present invention is used as a pesticide, other herbicides, various insecticides, acaricides, nematicides, fungicides, plant growth regulators may be used as needed when formulating or spraying. It may be mixed and applied with an agent, a synergist, a fertilizer, a soil conditioner and the like.

[0320] In particular, by mixing and applying other pesticides or plant hormones, it is expected that the cost can be reduced by reducing the amount of applied drug, the insecticidal spectrum can be expanded by the synergistic action of the mixed drug, and a higher pest control effect can be expected. On this occasion,
A combination with a plurality of known pesticides is also possible at the same time. Examples of the kind of pesticide to be used in mixture with the compound of the present invention include, for example, Farm Chemicals Handbook (Farm
Chemicals Handbook) 1999 edition. Specific examples of the common names are as follows, but are not necessarily limited thereto.

Fungicide: acibenzolar-S-methyl (aci
benzolar-S-methyl), acylaminobenzamide (acylam
inobenzamide), ambam, ampropyfos, anilazine, azaconazole, azoxystrobin (azoxystr)
obin), benalaxyl, benodanil (ben)
odanil), benomyl, benizol (benthl)
iazole), benzamacril, binapacryl, biphenyl, bitertanol, bethoxazine,
Bordeaux mixture, blasticidin-S
(Blasticidin-S), bromoconazol
e), bupirimate, buthiobate (buthi
obate), calcium polysul
fide), captafol, captan (c
aptan), copper oxychlorid
e), carpropamid, carbendazim, carboxin, CGA
-279202, quinomethionate, chlorobenthiazone, chlorfenazol, chloroneb, chloroneb, chlorothalonil, clozoline
inate), kufraneb (cufraneb), simoxanil (cym)
oxanil), cyproconazol, cyprodinil, cyprofuram,
Dazomet (dazomet), debacarb (debacarb), dichlorophen (dichlorophen), diclobutrazol (dic
lobutrazol), diclhlofluanid, diclomedine, dichlorane
n), dietofencarb, diclosymet, difenoconazole (difenocon)
azole), diflumetorim, dimethirimol, dimethomorp
h), diniconazole (diniconazole), diniconazole-M (diniconazole-M), dinocap (dinocap), diphenylamine (diphenylamine), dipyrithione (dipyr)
ithione), ditalimfos, dithianon, dodemorph, dozine
dine), drazoxolon, edifenphos, epoxyconazole (epoxiconazol)
e), etaconazole, ethimol (eth)
irimol), etridianol (etridiazole), famoxadone, fenarimol,
Febuconazole, fenamidone (fen
amidone), fendazosulam, fenfuram, fenhexamid
d), fenpiclonil, fenpropidin, fenpropim
orph), fentin, ferba
m), ferimzone, fluazinam (flua)
zinam), fludioxonil, fluoroimide, fluquinconazole (fluquinc)
onazole), flusilazole (flusilazole), flusulfamide (flusulfamide), flutranil (flutolani)
l), flutriafol, folpet, fosetyl-aluminum (fosetyl-alum)
inium), fuberidazole (fuberidazole), furalaxyl (furalaxyl), furametpyr (furametpyr) guazatine (guazatine), hexachlorobenzene (hexachlorob)
enzene), hexaconazole (hexaconazole), hymexazol (hymexazol), imazalil (imazalil), imibenconazole (imibenconazole), iminoctazine (i
minoctadine), ipconazole, iprobenfos, iprodione
e), isoprothiolane, iprovalicarb, kasugamy
cin), kresoxim-methyl, mancopper, mancozeb, maneb, maneb, mepanipyrim, mepronil, metalaxyl, metalconyl, metconazole, Metasulfocarb (metha
sulfocarb), metiram (metiram), metominostrobin (metominostrobin), microbutanyl (myclobutani)
l), MTF-753, nabam, nickel bis (dimethyldioca-bamate)
ithiocarbamate)), nitrotal-isopropyl (nitr
othal-isopropyl), nuarimol, NNF
-9425, octhilinone, off-race (of
urace), oxadixyl, oxycarboxin, oxpoconazole-fumarate, pefurzoa
te), penconazole, pencuron, phthalide, piperaline, polyoxins, potassium hydrogen carbonate (potassium hydrogen carbonate), probenazole (probenazole), prochloraz (prochloraz) ,
Procymidone, propamocarb hydrochloride, propiconazole (pr
opiconazole), propineb (propineb), pyrazophos (pyrazophos), pyrifenox (pyrifenox), pyrimethanil (pyrimethanil), pyrocuron (pyroquil)
on), quinomethionate, quinoxyfen, quintozene, RH
7281, sodium hydrogen carbonat
e), sodium hypochlorite, sulfur, spiroxamine, tebuconazole, technazen
e), tetraconazole, thiabendazole, thiadiazin / mi
lneb), thifluzamide, thiophanate-methyl, thiram,
Tolclofos-methyl, tolylfluanid, triadimefo
n), triadimenol (toriadimenol), triazoxide (triazoxide), tricyclazol (tricyclazol)
e), tridemorph, triflumizole, triforine, tricononazole, validamycin (valida)
mycin), vinclozolin, zinc sulfate (z
inc sulfate), zineb, ziram and shiitake mushroom mycelium extract.

Bactericide: streptomycin (st
reptomycin), tecloftalam, oxyterracycline, and oxolinic acid.

A nematicide: aldoxycar
b), cadusafos, fosthiazetate (fos)
thiazate), fosthietan, oxamyl and fenamiphos.

Acaricide: acequinocy
l), amitraz, bifenazate (bifenaz)
ate), bromopropylate, chinomethionat, chlorobenzylate (ch
lorobezilate), clofentezine,
Cyhexatine, dicofo (dicofo)
l), dienochlor, etoxazole (e)
toxazole), fenazaquin, fenbutatin oxide, fenpropathrin, fenproxi
mate), halfenprox, hexythiazox, milbemectin (milbe)
mectin), propargite, pyridaben, pyrimidifen and tebufenpyrad.

Insecticides: Abamectin, acephate, acetamipiri
d), aldicarb, allesulin (allet)
hrin), azinphos-methyl, bendiocarb, benfuracarb
acarb), bensultap, bifenthrin, buprofezin, butocarboxin, carbaryl
yl), carbofuran (carbofuran), carbosulfan (carbosulfan), cartap (cartap), chlorfenapyr (chlorfenapyr), chlorpyrifos (chlorpyrif)
os), chlorfenvinphos, chlorfluazuron (chlorfluazuron), clothianidin (clothianidin), chromafenozide (chromafenozid)
e), chlorpyrifos-methyl,
Cycloprothrin, cyfluthrin (c
yfluthrin), beta-cyfluthri
n), cypermethrin (cypermethrin), cyromazine (c
yromazine), cyhalothrin, lambda
Cyhalothrin (lambda-cyhalothrin), deltamethrin (deltamethrin), diafenthiuron (diafenthiuro)
n), diazinon, diacloden (diacl)
oden), diflubenzuron (diflubenzuron), dimethylvinphos (dimethylvinphos), diphenolane (dio
fenolan), disulfoton, dimetoe-
Dimethoate, emamectin benzoate (emamect)
in-benzoate), EPN, esfenvale
rate), ethiofencarb, ethiprole, etofenprox
ox), etrimfos, fenitrothion, fenobucarb, fenoxycarb, fenpropatrine (f
enpropathrin), fenvalerate, fipronil, fluacryplim
yrim), flucythrinate, flufenoxuron, flufenprox, tau-fluvalina
te), honophos, formenetate (forme)
tanate, formothion, furathiocarb, halofenozid
e), hexaflumuron, hydramethylnon, imidacloprid (imidac)
loprid), isofenphos, indoxacarb, isoprocar
b), isoxathion, lufenuron, malathion, metalaldehyde, metaldehyde, methamidophos,
Methidathion, methacrifos (methac)
rifos), metalcarb (metalcarb), methomil (meth)
omyl), mesoprene, methoxychlor, methoxyfenozide
ide), monocrotophos, muscar-
Les (muscalure), nidinotefuran,
Nitenpyram, omethoat (omethoat)
e), oxydemeton-methyl,
Oxamyl, parathion, parathion-methyl, permethrin, permethrin, phenthoate, phoxim, pholate, phosphoron (ph)
osalone), phosmet, phosphamidon, pirimicarb, pirimiphos-methyl, profenofos, protrifenbut
e), pymetrozine, pyraclofos (py
raclofos), pyriproxyfen, rotenone, sulprofos, silafluofen, spinosad
d), sulfotep, tebufenozide (teb
fenozide), teflubenzuron, tefluthorin, terbufos
s), tetrachlorovinphos, thiacloprid, thiocyc
lam), thiodicarb, thimethoxam, thiofanox,
Thiometon, tolfenp
yrad), tralomethrin, trichlorfon, triazuron, triflumuron and vamidion (vamid)
othion).

The applied amount of the compound of the present invention varies depending on the application scene, application time, application method, cultivated crops, etc., but is generally 0.000 per hectare (ha) as an active ingredient.
About 5 to 50 kg is appropriate.

[0327] Formulation examples of formulations using the compound of the present invention are shown below. However, the composition examples of the present invention are not limited to these. In the following formulation examples, "parts" means parts by weight.

[Wettable powder] Compound of the present invention 0.1 to 80 parts Solid carrier 5 to 98.9 parts Surfactant 1 to 10 parts Others 0 to 5 parts Others include, for example, anti-caking agents, decomposition inhibitors and the like. .

[Emulsion] 0.1 to 30 parts of the compound of the present invention 45 to 95 parts of a liquid carrier 4.9 to 15 parts of a surfactant 0 to 10 parts of others Examples of the others include a spreading agent and a decomposition inhibitor.

[Suspension] Compound of the present invention 0.1 to 70 parts Liquid carrier 15 to 98.89 parts Surfactant 1 to 12 parts Others 0.01 to 30 parts Others include, for example, an antifreezing agent and a thickener.

[Water dispersible granules] Compound of the present invention 0.1 to 90 parts Solid carrier 0 to 98.9 parts Surfactant 1 to 20 parts Others 0 to 10 parts Others include, for example, a binder and a decomposition inhibitor.

[Solution] 0.01 to 70 parts of the compound of the present invention 20 to 99.99 parts of the liquid carrier Others 0 to 10 parts Others include, for example, an antifreezing agent and a spreading agent.

[Granules] Compound of the present invention 0.01 to 80 parts Solid carrier 10 to 99.99 parts Others 0 to 10 parts Others include, for example, binders, decomposition inhibitors and the like.

[Powder] Compound of the present invention 0.01 to 30 parts Solid carrier 65 to 99.99 parts Others 0 to 5 parts Others include, for example, a drift inhibitor, a decomposition inhibitor and the like.

Next, more specific examples of the formulation of the pesticidal composition containing the compound of the present invention as an active ingredient are shown, but the present invention is not limited to these.

In the following formulation examples, “parts” means parts by weight.

[Compounding Example 1] Water-dispersible compound of the present compound No. 1 1 part 25 parts pyrophyllite 71 parts sorbole 5039 2 parts (mixture of nonionic surfactant and anionic surfactant: trade name of Toho Chemical Industry Co., Ltd.) Carplex # 80D 2 parts (synthetic water content) Silicic acid: Shionogi & Co., Ltd. product name) The above is uniformly mixed and pulverized to obtain a wettable powder.

[Formulation Example 2] Emulsion The present compound No. 1 15 parts xylene 75 parts N-methylpyrrolidone 15 parts sorbole 2680 5 parts (mixture of nonionic surfactant and anionic surfactant: trade name of Toho Chemical Industry Co., Ltd.) To make an emulsion.

[Formulation Example 3] Suspension The compound of the present invention no. 125 copies Agrisol S-710 10 parts (Nonionic surfactant: Kao Corporation trade name) Lunox 1000C 0.5 parts (Anionic surfactant: trade name of Toho Chemical Industry Co., Ltd.) Xanthan gum 0.2 parts 64.3 parts of water After mixing the above uniformly, wet pulverization is performed to obtain a suspension.

[Compounding Example 4] Water dispersible granule Compound No. 1 75 parts Hytenol NE-15 5 parts (anionic surfactant: Daiichi Kogyo Seiyaku Co., Ltd.) Vanirex N 10 parts (anionic surfactant: Nippon Paper Industries Co., Ltd.) Carplex # 80D 10 parts (Synthetic hydrous silicic acid: trade name of Shionogi & Co., Ltd.) After uniformly mixing and pulverizing the above, adding a small amount of water, mixing and kneading, granulating with an extrusion granulator, and drying. To give a wettable powder.

Formulation Example 5 Granules Compound of the present invention No. 5 15 parts 50 parts bentonite 50 parts talc 45 parts or more are uniformly mixed and pulverized, and then a small amount of water is added, and the mixture is kneaded with stirring, granulated by an extrusion granulator, and dried to obtain granules.

[Formulation Example 6] Powder The compound of the present invention no. 1 3 copies Carplex # 80D 0.5 parts (Synthetic hydrated silica: trade name of Shionogi & Co., Ltd.) Kaolinite 95 parts 1.5 parts of diisopropyl phosphate The above is uniformly mixed and pulverized to obtain a powder.

For use, the above-mentioned wettable powder, emulsion, flowable and granular wettable powder are diluted 50 to 20,000 times with water to give an active ingredient of 0.005 to 0.005 per hectare (ha).
Spray to 50kg.

[0344]

[Examples] The synthesis examples and test examples of the compound of the present invention are specifically described below as examples, but the present invention is not limited to these examples.

[Synthesis Example 1] 1- (3,5-dichloro-1)
-Methylpyrazol-4-yl) 2-cyano-2- (2-
Synthesis of (quinolylthio) vinyl-2,2-dimethylpropanoate (Compound No. 33) (A) In a solution of 3.0 g of 2-quinolinthiol in 30 ml of acetonitrile, 2.7 g of potassium carbonate is added. Further, 1.47 g of chloroacetonitrile was added at room temperature, and the mixture was stirred overnight. The reaction solution was added to ice water and extracted with ethyl acetate. The aqueous layer was extracted with ethyl acetate, combined with the above organic layer, and washed with water. After drying over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography (hexane: ethyl acetate = 4: 1).
To give 3.49 g of 2- (2-quinolylthio) ethanenitrile.

(B) 0.5 g of 2- (2-quinolylthio) ethanenitrile synthesized above was dissolved in 10 ml of THF, and 3,5-dichloro-1-methylpyrazole-4 was added.
0.53 g of carbonyl chloride was added. 0.62 g of potassium t-butoxide was added under ice cooling, and the mixture was stirred at room temperature for 2 hours. Add pivaloyl chloride 0.3 to the reaction solution.
2 g was added, and the mixture was further stirred at room temperature for 2 hours. The reaction solution was added to ice water and extracted with ethyl acetate. The aqueous layer was extracted with ethyl acetate, combined with the above organic layer, and washed with water. After drying over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane: ethyl acetate = 4: 1).
Z obtained as a mixture.

Table 2 shows the structure and melting point of the compound of the present invention synthesized according to the above-mentioned scheme or the above-mentioned synthesis examples.
Those not particularly described are mixtures of E-form and Z-form. The abbreviations in the table have the same meaning as described above. [Table 3]

[0348]

Embedded image

[0349]

[Table 3] ――――――――――――――――――――――――――――――――――― No. WEB A Melting point (℃), isomer Ratio ―――――――――――――――――――――――――――――――――――― 1 2-Cl-Ph OH A10 205-207 2 2- Cl-Ph O COtBu A10 Resin 3 3-Cl-Ph OH A10 194-198 4 3-Cl-Ph O COtBu A10 Resin, E / Z mixture 5 3-Cl-Ph O COtBu A41 Resin 6 4 -Cl-Ph OH A10 190-193 7 4-Cl-Ph O COtBu A10 resin, 10/1 8 4-Cl-Ph O COtBu 3-Cl-Ph resin, 2/1 9 2-Me-Ph SH A10 158-163 10 2-Me-Ph S COtBu A10 Resin 11 2-Me-Ph SH A46 110-112 12 2-Me-Ph S COtBu A46 Resin 13 3-Me-Ph SH A10 108-110 14 3 -Me-Ph S COtBu A10 Resin 15 4-Me-Ph SH A2 146-150 16 4-Me-Ph S COtBu A2 Resin 5/1 17 4-Me-Ph SH A10 102-106 18 4-Me -Ph S COtBu A10 115-116 19 2-Cl-Ph SH A10 200 20 2-Cl-Ph S COtBu A10 Resin 21 2-Cl-Ph SH A40 200 22 2-Cl-Ph S COtBu A40 84-86 23 3-Cl-Ph S COtBu A10 Resin, 2 / 1 24 4-Cl-Ph SH A10 135-137 25 4-Cl-Ph S COtBu A10 Resin 26 2-Philid SH A1 166-168 27 2-Prichyl S COtBu A1 Resin, E-form or Z-form 28 5 -Me-2-Pyridine S COtBu A10 Resin, 6/1 295-NO ₂ -2-Phenyl S COtBu A10 109-113, E-form or Z-form 30 2-Primidinyl S COtBu A1 Resin-like, 3/1 31 4-CF ₃ -2-Primidinyl S COtBu A10 resin, 1/2 32 2-quinolyl SH A1 190-193 33 2-quinolyl S COtBu A1 resin, 5/4 34 2-quinolyl SH A10 106-110 35 2 -Quinolyl S COtBu A10 Resin, 2 / 136-Benzothiothiazolyl S COtBu A10 Resin, 2/1 37 2-Benzothioxadoxyl S COtBu A10 Resin, 2/1 385-Me-2-thiazoasodryl S COtBu A10 93-97, E-form or Z-form 39 Ph SO ₂ H A2 155-157 40 4-Cl-PhCH ₂ SO ₂ H A2 Resin-like 41 2-polysilyl SO ₂ H 3-Cl-Ph 160-164 42 2- Broadcast SO ₂ H A48 143-144 43 tBu SO ₂ H A10 119-122 44 tBu SO ₂ COtBu A10 Resin ―――――――――――――――――――――――――――――――――――

[Table 4]

[0351]

Embedded image

[0352]

[Table 4] ―――――――――――――――――――――――――――――――――――  No. B A Melting point (℃), isomer ratio ――――――――――――――――――――――――――――――――――― 45 H A10 127-130 46 COtBu A10 Resin-like ―――――――――――――――――――――――――――――――――――

[Table 5]

[0354]

Embedded image

[0355]

[Table 5] ―――――――――――――――――――――――――――――――――――  No. B A Melting point (℃), isomer ratio ――――――――――――――――――――――――――――――――――― 47 H A10 128-132 48 COtBu A10 Resin-like ―――――――――――――――――――――――――――――――――――

[Table 6]

[0357]

Embedded image

[0358]

[Table 6] ―――――――――――――――――――――――――――――――――――  No. B A Melting point (℃), isomer ratio ――――――――――――――――――――――――――――――――――― 49 H A10 91-95 ―――――――――――――――――――――――――――――――――――

Next, the usefulness of the compound of the present invention as a pesticide will be specifically described in the following test examples.

Test Example 1 Insecticidal Test Against Brown Planthopper A 5% emulsion of the compound of the present invention described in the specification (25% wettable powder was used depending on the compound) was diluted with water containing a spreading agent. It was prepared into a chemical solution having a concentration of 500 ppm. This chemical was sprayed in a sufficient amount on the foliage of rice planted in a 1/2000 al pot. After air-drying, the cylinder was erected and 10 larvae of the brown planthopper, 2nd instar, were released per pot, covered, and stored in a thermostat. The survey was conducted after 6 days, and the mortality was determined from the following formula. The test was performed in two sections.

[0361]

## EQU1 ## Insect rate (%) = [number of dead insects / (number of dead insects + number of surviving insects)] × 100

As a result, the following compounds showed a mortality of 80% or more. The compound of the present invention no. : 2, 4, 7, 19, 20, 27,
28, 41.

[Test Example 2] Insecticidal test against black leafhopper Rice foliage was immersed in an emulsion of the compound of the present invention at a concentration of 500 ppm for about 10 seconds, and the foliage was placed in a glass cylinder to exhibit resistance to organophosphorus pesticides. Release the adult leafhopper, shown below, cover it with a perforated lid and store it in a constant temperature room at 25 ° C.
The number of dead insects after the day was investigated, and the mortality was calculated from the same formula as in Test Example 1. In addition, the test was performed in two sections system. As a result, the following compounds showed a mortality of 80% or more. The compound of the present invention no. : 4, 7, 14, 23, 35, 4
0, 42, 43, 44, 45, 46, 49.

[Test Example 3] Insecticidal test against peach aphid Moist filter paper was spread on a glass dish having an inner diameter of 3 cm, and cabbage leaves of the same diameter were placed thereon. Four adult wingless female peach aphids were released, and one day later, a chemical solution was sprayed (2.5 mg / cm 2) using a rotary spray tower. The drug solution was prepared by diluting a 5% emulsion of the compound of the present invention described in the specification (25% wettable powder was used depending on the compound) with water containing a spreading agent.
The one adjusted to a concentration of 00 ppm was used. Six days after the treatment, the mortality of adults and larvae was determined by the following formula. The test was performed in two sections.

[0365]

[Equation 2] Death rate (%) = [Number of dead insects / (Number of dead insects + Number of surviving insects)] × 100

As a result, the following compounds exhibited a mortality of 80%. The compound of the present invention no. : 2, 3, 4, 7, 10, 14, 1
6, 18, 23, 25, 34, 35.

Test Example 4 Contact Insecticidal Test on Japanese Conger The kanran leaves were immersed in a 500 ppm aqueous emulsion of the compound of the present invention for about 10 seconds, air-dried and placed in a petri dish. Ten larvae were released per dish, covered with a perforated lid and housed in a thermostat at 25 ° C. The number of dead larvae after 6 days was investigated, and the mortality was calculated from the same formula as in Test Example 1. I asked. In addition, the test was performed in two sections system. As a result, the following compounds showed a mortality of 80% or more. The compound of the present invention no. : 4, 6, 7, 14.

Test Example 5 Test of Acaricidal Activity against Spider Mite A kidney leaf was cut into a circular shape having a diameter of 3.0 cm using a leaf punch and placed on a wet filter paper on a styrol cup having a diameter of 7 cm. In addition, one spider mite larva per leaf
0 animals were inoculated. 5% of the compound of the invention described in the description
The emulsion (a 25% wettable powder is used depending on the compound) is diluted with water containing a spreading agent to prepare a chemical solution having a concentration of 500 ppm, and the chemical solution is used in a rotary spraying tower in an amount of 2 ml per styrene cup. Spray and store in a 25 ° C constant temperature room, 96
The mortality after the elapse of time was determined from the same formula as in Test Example 1. The test was performed in two sections. As a result, the following compounds showed a mortality of 80% or more. The compound of the present invention no. : 1,2,3,4,5,6,7,
9, 10, 13, 14, 16, 18, 20, 23, 2
5.

[0369]

As a result of the long-term use of insecticides and fungicides, pests have recently gained resistance, making it difficult to control with conventional insecticides and fungicides. Some insecticides are highly toxic, and some are persisting in ecosystems due to persistence. Accordingly, the present invention provides a novel insecticide or fungicide with low toxicity and low residual.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A01N 43/60 A01N 43/60 4C063 C07D 213/26 C07D 213/26 4H006 213/30 213/30 4H011 213 / 61 213/61 213/64 213/64 213/70 213/70 213/71 213/71 213/74 213/74 213/79 213/79 213/80 213/80 217/04 217/04 217/24 217 / 24 217/26 217/26 231/12 231/12 D 231/14 231/14 231/16 231/16 231/18 231/18 233/64 103 233/64 103 249/06 502 249/06 502 249 / 08 535 249/08 535 263/32 263/32 263/34 263/34 275/02 275/02 277/22 277/22 277/24 277/24 277/26 277/26 277/32 277/32 333 / 16 333/16 401/06 401/06 401/12 401/12 403/12 403/12 405/12 405/12 409/06 409/06 409/12 409/12 413/06 413/06 413/12 413/12 417/06 417/06 417/12 417/12 (72) Inventor Toshiro Miyake Minami Saitama-gun, Saitama 1470 Okamachi Shirooka, Nissan Chemical Industry Co., Ltd., Biological Sciences Laboratory (72) Inventor Takii Shinji 1470 Shirookamachi Oaza, Shirooka-machi, Minamisaitama-gun, Saitama Prefecture Nissan Chemical Industry Co., Ltd., Biological Sciences Research Institute (72) Inventor Toshinori Ito, Minami Saitama-gun, Saitama 1470 Shiraokacho, Shirooka 1470 Nissan Chemical Industry Co., Ltd. Biological Science Laboratory F-term (reference) 4C023 BA01 4C033 AD03 AD10 AD17 4C034 AB10 AN01 4C055 AA01 BA02 BA03 BA06 BA13 BA17 BA39 BA42 BA47 BB02 BB03 BB04 CA01 CA02 CA17 CB02 CB03 CB04 DA01 DB03 DB04 4C056 AA01 AB01 AC02 AD01 AE03 AF05 BA08 BB02 BC02 4C063 AA01 BB04 BB08 CC22 CC29 CC51 CC52 CC58 CC62 CC67 CC75 CC92 DD03 DD04 DD06 DD07 DD10 DD12 DD14 DD15 DD22 DD29 DD52 DD58 DD62 EE03 4H006 AA01 AB02 BC02 BC07 BC09 BC17 BC18 BC19 BC20 DA02 DA13 DA15 DA16 DC01 DC04 DC05 DC06 DC08 DD03 DH03 DH14

Claims (7)

[Claims] 1. Formula (1): Embedded image [Where, A is Y¹Optionally substituted phenyl, Y¹Replace with
Naphthyl or Y¹Is replaced by
A heterocyclic group (provided that the heterocyclic group is a thienyl,
Ryl, pyrrolyl, oxazolyl, isoxazolyl, thia
Zolyl, isothiazolyl, pyrazolyl, imidazolyl,
1,3,4-oxadiazolyl, 1,2,4-oxadi
Azolyl, 1,3,4-thiadiazolyl, 1,2,4-
Thiadiazolyl, 1,2,4-triazolyl, 1,2,2
3-thiadiazolyl, 1,2,3-triazolyl, 1,
2,3,4-tetrazolyl, pyridyl, pyrimidinyl,
Pyrazinyl, pyridazinyl, 1,3,5-triazini
1,2,4-triazinyl, indazolyl, benzo
Oxazolyl, quinolyl, isoquinolyl, quinoxalini
, Phthalazinyl, cinnolinyl or quinazolinyl
is there. ) B is H, C₁~ C_FourAlkyl, C_Two~ C₆Alkenyl, C
_Two~ C₆Alkynyl, C ₁~ C_FourHaloalkyl, C_Two~ C₆C
Loalkenyl, C_Two~ C₆Haloalkynyl, C_Two~ C_FourAl
Coxyalkyl, CH_ThreeSCH_Two, CH_ThreeOC_TwoH_FourOC
H_Two, R^aC substituted with₁~ C_FourAlkyl, R^bReplaced by
C₁~ C_FourAlkyl, tetrahydropyranyl, (CH
_Three)_ThreeSi, C₁~ C_FourAlkylsulfonyl, halogen if
Kuha C₁~ C_FourPhenyl optionally substituted with alkyl
Sulfonyl, -SO_TwoCF_Three, C₁~ C_FourMonoalkylami
Nosulfonyl, C_Two~ C₈Dialkylaminosulfonyl,
Phenylaminosulfonyl, C_Two~ C_FiveCyanoalkyl,
C_Three~ C₉Alkoxycarbonylalkyl, -C (= O)
T¹, -C (= S) T¹, Alkali metal atoms, alkaline earth
Kind of metal atom or NHT^FourT^FiveT⁶And Q is -OW¹, -S-W¹, -NR¹-W^Two, -SO-
W^Three, -SO_Two-W^Three, Embedded image And W¹And W^TwoAre each independently Y^TwoMay be replaced by
Phenyl, Y^TwoOptionally substituted naphthyl, Y^Twoso
An optionally substituted heterocyclic group (provided that the heterocyclic group
Is thienyl, furyl, pyrrolyl, oxazolyl, iso
Xazolyl, thiazolyl, isothiazolyl, pyrazoly
, Imidazolyl, 1,3,4-oxadiazolyl,
1,2,4-oxadiazolyl, 1,3,4-thiadia
Zolyl, 1,2,4-thiadiazolyl, 1,2,4-to
Liazolyl, 1,2,3-thiadiazolyl, 1,2,3
-Triazolyl, 1,2,3,4-tetrazolyl, pyri
Jill, pyrimidinyl, pyrazinyl, pyridazinyl, 1,
3,5-triazinyl, 1,2,4-triazinyl,
Benzoxazolyl, benzothiazolyl, benzimidazo
Lil, indazolyl, benzofuranyl, thianaphtheni
, Indolyl, benzisoxazolyl, benzisothi
Azolyl, benzotriazolyl, benzooxadiazoli
Benzothiadiazolyl, quinolyl, isoquinolyl,
Quinoxalinyl, phthalazinyl, cinnolinyl or
Nazolinyl. ) Or Embedded image And W^ThreeIs Y^TwoOptionally substituted phenyl, Y^TwoPut in
Optionally substituted naphthyl, Y^TwoEven if replaced with
Good heterocyclic groups (provided that the heterocyclic groups are thienyl,
, Pyrrolyl, oxazolyl, isoxazolyl, thiazo
Ryl, isothiazolyl, pyrazolyl, imidazolyl,
1,3,4-oxadiazolyl, 1,2,4-oxadi
Azolyl, 1,3,4-thiadiazolyl, 1,2,4-
Thiadiazolyl, 1,2,4-triazolyl, 1,2,2
3-thiadiazolyl, 1,2,3-triazolyl, 1,
2,3,4-tetrazolyl, pyridyl, pyrimidinyl,
Pyrazinyl, pyridazinyl, 1,3,5-triazini
1,2,4-triazinyl, benzoxazolyl,
Benzothiazolyl, benzimidazolyl, indazoly
Benzofuranyl, tianaphthenyl, indolyl,
Benzoisoxazolyl, benzoisothiazolyl, benzoto
Liazolyl, benzooxadiazolyl, benzothiadia
Zolyl, quinolyl, isoquinolyl, quinoxalinyl,
Tarazinyl, cinnolinyl or quinazolinyl
You. ), C₁~ C_TenAlkyl, C_Two~ C₆Alkenyl, C_Two
~ C₆Alkynyl, C₁~ C₆Haloalkyl, C_Two~ C₆C
Loalkenyl, C _Two~ C₆Haloalkynyl, C_Three~ C₆Halo
Cycloalkyl, C₁~ C_ThreeEven if substituted with alkyl
Good C_Three~ C₆Cycloalkyl, C_Two~ C_FourAlkoxyal
Kill, C_Two~ C_FourAlkylsulfenylalkyl, Y^Twoso
Optionally substituted phenyl C₁~ C_FourAlkyl, Y^Two
Phenoxy C optionally substituted with₁~ C_FourAlkyl,
Y^TwoOptionally substituted phenylsulfenyl C₁~
C_FourAlkyl, Y^TwoPhenylsulfur optionally substituted
Finil C₁~ C_FourAlkyl, Y^TwoMay be replaced by
Phenylsulfonyl C₁~ C_FourAlkyl, Y^TwoReplaced by
Optionally substituted benzoyl C₁~ C_FourAlkyl, Y^TwoPut in
Optionally substituted phenoxycarbonyl C₁~ C_FourAl
Kill, Y^TwoAnilino C optionally substituted with₁~ C_FourA
Lequil, Y^TwoThienyl C optionally substituted with₁~ C_Four
Alkyl, Y^TwoPyridyl C optionally substituted with₁~ C
_FourAlkyl, tetrahydropyranyl, (CH_Three)_ThreeSi,
C_Two~ C_FiveCyanoalkyl, C_Three~ C₉Alkoxycarboni
Rualkyl, C_Three~ C₉Alkylcarbonylalkyl or
Is Embedded image And Z¹Is NR⁶, CHR⁶, O or S, Z^TwoIs NR⁷, CHR⁷, O or S, Z^ThreeIs NR⁸, CHR⁸, O or S, Z^FourIs NR⁹, CHR⁹, O or S, Y¹And Y^TwoIs independently halogen, C₁~ C_TenAl
Kill, C_Two~ C₆Alkenyl, C_Two~ C₆Alkynyl, C₁
~ C₆Haloalkyl, C_Two~ C₆Haloalkenyl, C_Two~ C
₆Haloalkynyl, C_Three~ C₆Halocycloalkyl, C₁~
C_ThreeC optionally substituted with alkyl_Three~ C₆Cycloa
Lucil, C₁~ C₆Alkoxy, C_Two~ C₆Alkenyloxy
Si, C_Two~ C₆Alkynyloxy, C₁~ C_FourHaloalkoki
Si, C_Two~ C₆Haloalkenyloxy, C_Two~ C₆Haloal
Quinyloxy, C_Two~ C_FourAlkoxyalkyl, R^aPut in
Transformed C₁~ C_FourAlkyl, C₁~ C_FourAlkylsulfe
Nil, C₁~ C_FourAlkylsulfinyl, C₁~ C_FourArchi
Rusulfonyl, C_Two~ C₆Alkenylsulfenyl, C_Two
~ C₆Alkenylsulfinyl, C_Two~ C₆Alkenyls
Ruphonyl, C_Two~ C₆Alkynylsulfenyl, C_Two~ C₆
Alkynylsulfinyl, C_Two~ C₆Alkynyl sulfo
Nil, C₁~ C_FourHaloalkylsulfenyl, C ₁~ C_FourC
Loalkylsulfinyl, C₁~ C_FourHaloalkyl sulfo
Nil, C_Two~ C₆Haloalkenylsulfenyl, C_Two~ C₆
Haloalkenylsulfinyl, C_Two~ C₆Haloalkenyl
Sulfonyl, C_Two~ C₆Haloalkynylsulfenyl, C
_Two~ C₆Haloalkynylsulfinyl, C_Two~ C₆Haloal
Quinylsulfonyl, NO_Two, CN, -NU¹U^Two, Feno
Xy, OH, naphthyl, C_Two~ C₇Alkoxycarboni
Le, C_Two~ C_FourAlkylcarbonyl, C_Two~ C_FiveAlkylka
Rubonyloxy, C_Two~ C_FiveHaloalkylcarbonyloxy
X¹A benzoyl optionally substituted with¹Replace with
Optionally substituted phenyl, X¹May be replaced by
Pyridyl, X¹Thienyl optionally substituted with
And -N = CT⁷T⁸1 to 4 arbitrarily selected from
Or an alkylene bonded at an adjacent substitution position
A 5- to 8-membered ring formed by T¹Is C₁~ C₂₀Alkyl, C_Two~ C₆Alkenyl, C_Two
~ C₆Alkynyl, C₁~ C₆Haloalkyl, C_Two~ C₆C
Loalkenyl, C_Two~ C₆Haloalkynyl, C_Three~ C₆Halo
Cycloalkyl, C₁~ C_ThreeEven if substituted with alkyl
Good C_Three~ C₆Cycloalkyl, C_Two~ C_FourAlkoxyal
Kill, R^aC substituted with₁~ C_FourAlkyl, R^aReplaced by
C_Three~ C₆Cycloalkyl, R^aAnd C₁~ C_FourAl
A cyclopropyl substituted with a kill, R^cAnd halogen
C substituted with_Three~ C_FourCycloalkyl, R^dAnd C₁~
C_FourCyclopropyl substituted with alkyl, R^aReplaced by
C_Two~ C_FourAlkenyl, C₁~ C₁₂Alkoxy, C_Two~
C_FiveAlkenyloxy, C_Two~ C_FiveAlkynyloxy, C₁
~ C_FourHaloalkoxy, C_Two~ C₆Haloalkenyloxy
Si, C_Two~ C₆Haloalkynyloxy, C₁~ C_ThreeAlkyl
C optionally substituted with_Three~ C₆Cycloalkoxy,
Ndyloxy, C₁~ C₆Alkylsulfenyl, C_Two~
C₆Alkenylsulfenyl, C_Two~ C₆Alkynylsul
Phenyl, C_Two~ C_FiveAlkoxycarbonyl, -NU
¹U^Two, Phenylamino, X^TwoMay be replaced by
Enil, X^TwoA phenoxy optionally substituted with^Twoso
Optionally substituted phenylsulfenyl, X^TwoPut in
Optionally substituted naphthyl or X^TwoIs replaced by
5- or 6-membered heterocyclic group (however,
Elementary ring groups are thienyl, furyl, pyrrolyl, oxazolyl,
Isoxazolyl, thiazolyl, isothiazolyl, pyrazo
Ryl, imidazolyl, 1,3,4-oxadiazolyl,
1,2,4-oxadiazolyl, 1,3,4-thiadia
Zolyl, 1,2,4-thiadiazolyl, 1,2,4-to
Liazolyl, 1,2,3-thiadiazolyl, 1,2,3
-Triazolyl, 1,2,3,4-tetrazolyl, pyri
Jill, pyrimidinyl, pyrazinyl, pyridazinyl, 1,
Of 3,5-triazinyl and 1,2,4-triazinyl
Selected from inside. ) T^Four, T^FiveAnd T⁶Is independently H, C₁~ C₆Archi
Le, C₁~ C₆Alkenyl, C₁~ C_ThreeSubstituted with alkyl
May be C_Three~ C₆With cycloalkyl or benzyl
There is or T^Four, T^FiveAnd T⁶Two of them
Oxygen atom and nitrogen source together with nitrogen atom
5- to 8-membered ring optionally containing a substituent or a sulfur atom
Form a group, T⁷And T⁸Are each independently H, phenyl, benzyl or
Or C₁~ C₆Alkyl or T⁷And T⁸And
Form a 5- to 8-membered ring with the carbon atoms
Well, X¹And X^TwoIs independently halogen, C₁~ C_FourArchi
Le, C₁~ C_FourHaloalkyl, C₁~ C_FourAlkoxy, C₁
~ C_FourHaloalkoxy, C₁~ C_FourAlkylsulfeni
Le, C₁~ C_FourAlkylsulfinyl, C₁~ C_FourAlkyl
Sulfonyl, C_Two~ C_FiveAlkenylsulfenyl, C_Two~
C_FiveAlkenylsulfinyl, C_Two~ C_FiveAlkenyl sulf
Honyl, C₁~ C_FourHaloalkylsulfenyl, C₁~ C_Four
Haloalkylsulfinyl, C₁~ C_FourHaloalkylsul
Honyl, NO_Two, CN, CHO, OH, -NU¹U^Two,
Phenyl, phenoxy and C_Two~ C_FiveAlkoxycarboni
1 to 5 substituents arbitrarily selected from
And U¹And U^TwoIs independently H, C₁~ C₆Alkyl, C
_Two~ C_FiveAlkylcarbonyl, C_Two~ C_FiveAlkoxycarbo
Nyl, phenyl or benzyl, or U¹And U^TwoAnd
Form a 5- to 8-membered ring with the carbon atoms
Well, R¹Is H, C₁~ C₆Alkyl, C_Two~ C_FiveAlkyl cal
Bonil, C_Two~ C_FiveAlkoxycarbonyl, phenyl or
Is benzyl, R^TwoAnd R^ThreeIs independently H, halogen, C₁~ C_FourA
Lucil, C₁~ C_FourHaloalkyl, C₁~ C_FourAlkoxy,
C₁~ C_FourHaloalkoxy, C₁~ C_FourAlkylsulfeni
Le, C₁~ C_FourAlkylsulfinyl, C₁~ C_FourAlkyl
Sulfonyl, C _Two~ C_FiveAlkenylsulfenyl, C_Two~
C_FiveAlkenylsulfinyl, C_Two~ C_FiveAlkenyl sulf
Honyl, C₁~ C_FourHaloalkylsulfenyl, C₁~ C_Four
Haloalkylsulfinyl, C₁~ C_FourHaloalkylsul
Honyl, NO_Two, CN, CHO, OH, -NU¹U^Two,
Phenyl, phenoxy and C_Two~ C_FiveAlkoxycarboni
1 to 4 substituents arbitrarily selected from
And R^Four, R^Five, R⁶, R⁷, R⁸And R⁹Is independently H,
C₁~ C₆Alkyl, X ^TwoPhenyl which may be substituted with
Or X^TwoIs benzyl optionally substituted with R^aIs halogen and C₁~ C_FourSelected from alkyl
Phenyl optionally substituted with one or more kinds, R^bIs halogen and C₁~ C_FourSelected from alkyl
Benzoyl optionally substituted with one or more kinds, R^cIs halogen and C₁~ C_FourSelected from alkoxy
Phenyl optionally substituted with one or more R^dRepresents C which may be substituted with halogen_Two~ C_FourAl
Kenyl, n represents the number of methylene groups and is 0, 1 or 2.
You. ] One or more acrylonitrile compounds represented by
Insecticidal mites characterized by containing as an active ingredient
Agent. 2. The formula (1) according to claim 1, wherein A, B and Q represent the same meaning as in claim 1, Where A is Y¹Is phenyl optionally substituted
And W¹Is Y^TwoOf phenyl optionally substituted with
If B is C₁~ C_FourAlkyl, C_Two~ C₆Alkenyl, C_Two~
C₆Alkynyl, C₁~ C_FourHaloalkyl, C_Two~ C₆Halo
Alkenyl, C_Two~ C₆Haloalkynyl, C_Two~ C _FourArco
Xyalkyl, CH_ThreeSCH_Two, CH_ThreeOC_TwoH_FourOCH_Two,
R^aC substituted with₁~ C_FourAlkyl, R^bC substituted with
₁~ C_FourAlkyl, tetrahydropyranyl, (CH_Three)_ThreeS
i, C₁~ C_FourAlkylsulfonyl, halogen or C
₁~ C_FourPhenylsulfo optionally substituted with alkyl
Nil, -SO_TwoCF_Three, C₁~ C_FourMonoalkylaminosul
Honyl, C_Two~ C₈Dialkylaminosulfonyl, phenyl
Luminosulfonyl, C_Two~ C_FiveCyanoalkyl, C_Three~
C₉Alkoxycarbonylalkyl, -C (= O) T¹,
−C (= S) T¹, Alkali metal atom, alkaline earth gold
Genus atom or NHT^FourT^FiveT⁶It is. The action represented by]
Lilonitrile compounds. Wherein A is substituted by substituted in a naphthyl or Y ¹ Hajime Tamaki in Y ¹ (provided that the heterocyclic group are thienyl, furyl, pyrrolyl, oxazolyl, isoxazolyl, Thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, 1,3,4-oxadiazolyl, 1,2,4-oxadiazolyl, 1,3
4-thiadiazolyl, 1,2,4-thiadiazolyl,
1,2,4-triazolyl, 1,2,3-thiadiazolyl, 1,2,3-triazolyl, 1,2,3,4-tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,3,5-triazinyl, 1,2,4-triazinyl, indazolyl, benzoxazolyl, quinolyl, isoquinolyl, quinoxalinyl, phthalazinyl,
Cinnolinyl or quinazolinyl. 3. The acrylonitrile compound according to claim 2, wherein Wherein W ¹ is naphthyl which may be substituted with Y ^2, Y ² Hajime Tamaki which may be substituted with (provided that the heterocyclic group are thienyl, furyl, pyrrolyl, oxazolyl, isoxazolyl , Thiazolyl, isothiazolyl,
Pyrazolyl, imidazolyl, 1,3,4-oxadiazolyl, 1,2,4-oxadiazolyl, 1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,2
4-triazolyl, 1,2,3-thiadiazolyl, 1,
2,3-triazolyl, 1,2,3,4-tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,3,5-triazinyl, 1,2,4-triazinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, indazolyl Benzofuranyl, thianaphthenyl, indolyl, benzoisoxazolyl, benzoisothiazolyl, benzotriazolyl, benzooxadiazolyl, benzothiadiazolyl, quinolyl, isoquinolyl, quinoxalinyl, phthalazinyl, cinnolinyl or quinazolinyl. ) Or The acrylonitrile compound according to claim 2, which is 5. B is C ₁ -C ₄ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C ₁ -C ₄ haloalkyl,
C ₂ ~C ₆ haloalkenyl, C ₂ ~C ₆ haloalkynyl, C
₂ -C _{4 alkoxyalkyl, CH 3 SCH 2, CH 3} OC 2
H ₄ OCH _2, R ^a with substituted C ₁ -C ₄ alkyl, R ^b substituted by a C ₁ -C ₄ alkyl, tetrahydropyranyl,
(CH ₃ ) ₃ Si, C ₁ -C ₄ alkylsulfonyl, phenylsulfonyl optionally substituted by halogen or C ₁ -C ₄ alkyl, —SO ₂ CF ₃ , C ₁ -C ₄ monoalkylaminosulfonyl, C ₂ -C ₈ dialkylaminosulfonyl, phenylaminosulfonyl, C ₂ -C ₅ cyanoalkyl, C ₃ -C ₉ alkoxycarbonylalkyl, -C
^{(= O) T 1, -C} (= S) T 1, alkali metal atom, an alkaline earth metal atom or NHT ⁴ T ⁵ is T ⁶ claim 2 acrylonitrile compounds described. 6. An agricultural chemical comprising one or more of the acrylonitrile compounds according to claim 2 as an active ingredient. 7. An insecticidal acaricide comprising at least one acrylonitrile compound according to claim 2 as an active ingredient.