JP2003010222A - Urine bag and urine guide bag system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a urine bag which suppresses coloring by indigo by inhibiting the color formation of indican contained in urine sampled or guided. SOLUTION: Laminated end parts of two transparent sheets are sealed to make a bag body 2 with the capacity of about 2,500 ml, a support bar 6 is incorporated into an upper part thereof and a hole for a grasping part is provided at the center part right below the support bar 6. Moreover, a chamber 7 is provided at an end part thereof right below it and provided with a hydrophobic filter 8. Furthermore, one end of a urine guide tube 3 having a groove part disposed on an inner wall in the longitudinal direction thereof is connected to the chamber 7, a connection part 5 is incorporated into the other end of the urine guide tube 3 and a urine discharge tube 4 is installed at a lower part of the bag body 2. A slide 9 is mounted on the urine guide tube 4 to open or close the tube.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a urine bag used for a patient with a urinary tract disorder, a bag for storing the urine of the patient, a bag for storing the urine, and a urinary tube for introducing the urine into the bag. The present invention relates to a urinary bag system including a urine drainage tube for discharging urine from a bag.

[0002]

2. Description of the Related Art When it is not possible for a patient to voluntarily urinate, such as in a patient with impaired urinary function, the tip of a Neraton catheter or balloon catheter for urination is placed from the urethra to the bladder, and urine is guided at the proximal end of this catheter. Connect the tube,
Urine is stored in the urine bag through this tube. The urine stored in the urine bag may be observed as a vital sign of the patient. For example, observing the color of urine after blood transfusion is an important confirmation item in medical procedures involving blood transfusion.

By the way, in urine, indican, which is a metabolite of the protein degradation product tryptophan,
can) is included. For example, urine contains indican at a normal value of 2 to 7.5 mg / dl, and when an abnormal amount of proteolysis occurs or when the degree of putrefaction in the intestine is increased (for example, constipation, colitis). ) 20 to 20
Contains 0 mg / dl.

In the urine having such an increased indican content, indica in the urine reacts to become indigo, which is a blue to purple dye, and floats in the urine or adheres to the urine bag. I had to do it. For this reason, the color is different from the original color of urine, which is extremely inconvenient for observing the color of urine.

Further, in the conventional urinary tube, the lumen has a circular cross section. Therefore, when the tube is kinked, the lumen of the tube is blocked and the flow path of urine is blocked, so that the urine is kept for a certain period of time. May stay in the urinary tube. In the case of a patient with a large amount of indica in the urine, this accumulated urine changes to indigo in a short time and develops color due to the small volume of the urine guiding tube, and indigo also adheres to the urinating tube. . Further, when the urinary tract is opened again, the urine containing the colored indigo flows into the urine bag, and it is often inconvenient to observe the properties of urine as described above.

[0006]

DISCLOSURE OF THE INVENTION The present invention is directed to indican contained in urine collected or urine collected.
It is intended to provide a urine bag which suppresses the color development of urine and suppresses the coloring due to indigo. In addition, the urinary tract is blocked by the kinking of the urine drainage tube, and in order to suppress coloring due to indigo that occurs when urine stays in the urine drainage tube, even if the urine drainage tube is kinked, the urinary tract is not blocked. Is to provide a urinary bag system having the following.

[0007]

The present invention can be solved by the following.

(1) A urine bag containing a color development inhibitor for indican in urine.

(2) The urine bag according to (1), wherein the color-developing inhibitor is a surfactant.

(3) The urine bag according to (1) or (2), wherein the color development inhibitor is a cationic surfactant.

(4) The color-forming inhibitor is a quaternary ammonium salt or a quaternary pyridinium salt having at least one organic group having 5 or more carbon atoms bonded to a nitrogen atom. The urine bag according to (3).

(5) The color-development inhibitor is at least one selected from the group consisting of cetylpyridinium chloride, benzalkonium chloride, cetyltrimethylammonium chloride and trioctylmethylammonium chloride. (1) The urine bag according to (4).

(6) A bag body for storing urine, a urine guiding tube for introducing urine at one end of the bag body, and a urine draining tube for discharging urine at the other end are provided inside thereof. A urinary bag system characterized by containing a color-suppressing agent for indican in urine.

(7) The urinary bag system according to (6), wherein the color development inhibitor is a surfactant.

(8) The urinary bag system according to (6) or (7), wherein the color development inhibitor is a cationic surfactant.

(9) From the above (6), the color development inhibitor is a quaternary ammonium salt or a quaternary pyridinium salt having at least one organic group having 5 or more carbon atoms bonded to a nitrogen atom. (8) The urine bag system according to the above.

(10) The color-development inhibitor is at least one selected from the group consisting of cetylpyridinium chloride, benzalkonium chloride, cetyltrimethylammonium chloride and trioctylmethylammonium chloride. (6) (9) The introduction bag system according to the above.

(11) The urinary tract can secure a urinary tract even if it is kinked (6) to (10)
The described urinary bag system.

(12) The urine drainage bag system according to (11), characterized in that the urine drainage tube has a groove portion arranged in a longitudinal direction on an inner wall of the urine drainage tube.

(13) The urine bag system according to (6) to (12), wherein the bag body, the urine drainage tube, and the urine drainage tube are made of EVA.

[0021]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention relates to indican (i) in urine.
The present invention relates to a urine bag and a urinary bag system capable of suppressing coloring due to indigo by suppressing the color development reaction of Nd. The details will be described below with reference to the drawings. FIG. 1 is a front view of the urinary bag system of the present invention. FIG. 2 is a sectional view taken along the line AA ′ of FIG. INDUSTRIAL APPLICABILITY The present invention can suppress the change of indican in urine into indigo by inserting a specific substance into the urine bag and urine bag system 1.

The urine bag system 1 comprises a bag body 2 for storing urine, a urine tube 3 and a urine tube 4. At the tip of the urine drainage tube 3, there is provided a connecting portion 5 that can be connected to the base of a Neraton catheter or a balloon catheter for urine drainage that is placed in the bladder from the urethra. The bag body 2 and the urine guiding tube 3 are preferably transparent or translucent so that the property of urine such as color can be confirmed from the outside.

When the connecting part 5 is connected to the base of a Neraton catheter or a urinary balloon catheter placed in the bladder, the urine in the bladder flows from the urinary guide tube 3 into the bag body 2 through the catheter, Stored in body 2. After observing the properties of the urine that has been stored in a fixed amount, the slide clamp 9 provided in the urination tube 4 is operated to open,
It is discharged through the urination tube 4.

When the amount of indican in the urine is increased, the urine stored in the bag body 2 becomes indigo due to the reaction of the indican contained in the urine, and the urine in the bag body 2 is in the urine. It floats on the surface and indigo adheres to the bag body 2, resulting in a color different from the original color of urine. The present invention is characterized in that a color development inhibitor is added in order to suppress the color development of such indican in urine.

Surfactants in the present invention, particularly cationic surfactants; urine bags and guides containing a quaternary ammonium salt or quaternary pyridinium salt having at least one organic group having 5 or more carbon atoms bonded to a nitrogen atom. In the case of the urine bag system 1, the original color of urine can be maintained.

This is because indicans present in urine are surfactants, especially cationic surfactants; quaternary ammonium salts or quaternary pyridinium having at least one organic group having 5 or more carbon atoms bonded to a nitrogen atom. It is considered that the presence of salt suppressed the reaction to indigo.

The cationic surfactant is not particularly limited, and examples thereof include quaternary ammonium type cationic surfactants such as tetraalkylammonium type and pyridinium type; amine salt type cationic surfactants. The quaternary ammonium salt or quaternary pyridinium salt is a quaternary ammonium salt or a quaternary pyridinium salt having at least one organic group having 5 or more carbon atoms bonded to a nitrogen atom. If there is no particular limitation, examples thereof include compounds represented by the following formulas (I) to (III).

[0028]

[Chemical 1] (In the formula, R¹ , R² And R^Five Is an alky with 5 or more carbons
A straight-chain alkyl group having 8 to 18 carbon atoms.
It is a ru basis. R³ , R^Four , R⁶ , R⁷ And R ⁸Is that
Each is an alkyl group having 1 or more carbon atoms. ) Among them, cetylpyridinium chloride represented by the following formula (IV)
(Hereinafter abbreviated as CPC), chloride represented by the following formula (V)
Benzalkonium (in the formula, R⁹ Is C₈ H₁₇~ C₁₈H₃₇
Indicates. ), Cetyl trichloride represented by the following formula (VI)
Represented by methylammonium and the following formula (VII)
Selected from the group consisting of trioctylmethylammonium chloride
It is preferable that the number is at least one.

[0029]

[Chemical 2] Particularly, at least one selected from the group consisting of CPC, benzelkonium chloride and cetyltrimethylammonium chloride is preferable, and CPC or benzelkonium chloride is more preferable.

The specific substance for suppressing the coloration of urine by indigo produced by the reaction of indican in urine of the present invention is
One or more of the above substances (color-suppressing agents) may be used as the active ingredient, and may contain other ingredients. Also,
You may use the 1 type (s) or 2 or more types of the said substance (color development inhibitor) as it is.

In the present invention, the amount of the above-mentioned substance (coloring-inhibiting agent) that suppresses the coloring of urine and the urine bag by indigo generated by the reaction of indican in urine is 1 mg of indican.
It is preferably 1 mol or more with respect to 1. Within this range, when the urinary indican concentration is high (for example, the urinary indican concentration is 100 to 200 mg / d).
Even in the case of 1), color development can be suppressed.

In the present invention, the above-mentioned substance (color-suppressing agent) that suppresses the coloration of indigo caused by the reaction of indica in urine and the coloration of indigo in the urine bag exists in any state as long as it can contact with urine. You may let me. For example, it is sufficient to put the above substance (color development inhibitor) in the bag body 2 of the urine drainage bag system 1 of the present invention, or just put the above substance (color development inhibitor) in the urine drainage tube 3. Good. In addition, the above substance (color development inhibitor) may be put in both the bag body 2 and the urine drainage tube 3.

Further, a bag 2 is prepared by using a solvent which can dissolve or disperse the above-mentioned substance (color development inhibitor), usually an aquatic solvent.
It may be applied and fixed to the inner wall surface or the inner surface of the chamber 7, or may be added to the material of the urinary bag system 1.
Alternatively, the above-mentioned substance (color-suppressing agent) may be carried on a filter paper or a film, and this filter paper may be left in the bag body 2 or the urine drainage tube 3.

Similarly, the above substances may be present in the urination tube 4. Further, the above-mentioned substance (color-suppressing agent) formed in a block shape or a spherical shape may be fixed in the chamber 7 immediately below the connection port to the urine guiding tube 3. By doing so, the urine that has flowed in from the urine drainage tube 3 always comes into contact with the substance (color-suppressing agent) formed in a block shape or a spherical shape, so that the reaction of indican in the urine can be surely suppressed. it can.

The urinary bag system 1 of the present invention is
As shown in FIG. 2, a groove 23 is provided on the inner wall of the urine drainage tube 3 along the longitudinal direction. If the groove 23 is provided at one or more places, the urinary tract will not be blocked when kinking. In FIG. 2, the groove portions 23 are arranged at five equal intervals,
The cross section of the inner wall has a substantially star-shaped configuration,
By doing so, even if a kink occurs, the lumen is not completely blocked, and the five groove portions 23 serve as urinary tracts, and a sufficient urine flow rate can be secured.

The cross-sectional shape of the inner wall of the urine drainage tube 3 is not limited to this substantially star shape, and may be any shape that does not completely block the urinary tract even if it is kink, for example, hexagonal or octagonal. It does not matter if the grooves are arranged so as to be atypical.

By the way, the urine drainage tube may be kinked due to an unexpected load caused by the patient's posture change (for example, turning over). When a kink occurs, the urinary tract may be completely occluded if the cross section of the urine drainage tube is circular. The urine excreted by the patient remains in the urinary tube due to the blocked urinary tract. Coloring of urine due to indigo caused by the reaction of indican in urine frequently occurs when urine is retained, but it is difficult to color when urine is flowing.

Also from this, it is effective that the cross-sectional lumen of the urine drainage tube 3 has an atypical shape because the urinary tract is secured even if the urine drainage tube 3 is kinked. In particular, it is preferable to use a substantially star shape because of its ease of manufacturing. As a method for manufacturing the urine drainage tube 3 having a substantially star-shaped lumen cross section, the urine drainage tube 3 is extruded by an extrusion molding machine using a substantially star-shaped die and cut into a predetermined length.
Can be obtained, but is not limited to this method. Furthermore, in the present invention, the above substance (color development inhibitor) may be present in the urine guiding tube 3 to suppress the change of indican in urine into indigo.

Further, the bag body 2 of the present invention, the urine drainage tube 3,
The material of the urination tube 4 is not particularly limited, but is particularly EVA.
Is preferably used. By using EVA as a material, it is possible to allow the above-mentioned substance (coloring inhibitor), which has appropriate flexibility and is effective in suppressing the reaction of indicane, to exist in a stable state, and thus is easy to use. .
Further, the present invention is not limited to the urine bag system and may have any configuration as long as it is a container for storing urine such as a urine bag.

(Example 1) Two transparent sheets made of EVA were stacked and the ends were sealed to form a bag body 2 having a capacity of about 2500 ml. As shown in FIG. Incorporated. A hole for a gripping portion was provided in the central portion immediately below the support rod 6, and a polypropylene chamber 7 was provided at the immediately lower end portion thereof, and a hydrophobic filter 8 was provided in the chamber 7. Further, one end of the EVA urine drainage tube 3 was connected to the chamber 7. The EVA urine drainage tube 3 was extruded by an extrusion molding machine using a substantially star-shaped die so that five groove portions were arranged at equal intervals along the longitudinal direction on the inner wall thereof. Then, the polypropylene connecting portion 5 was incorporated into the other end of the EVA urine drainage tube 3.
The outer diameter of the EVA urinary tubing 3 was set to 9 mm, and the diameter of the substantially star-shaped lumen was set to 6.8 mm. An EVA urine drainage tube 4 is installed in the lower portion of the bag body 2, and a slide clamp 9 for opening and closing the tube is attached to the urine drainage tube 4. The bag body 2 is provided with a urine drainage tube storage portion 10 for storing the end portion of the urine drainage tube 4. The urinary bag system 1 thus produced has a connecting portion 15 that can be connected to a urinary balloon catheter placed in the bladder of a patient. When this urinary balloon catheter is connected to the connecting portion 15,
Urine is stored in the bag body 2 through the urine guiding tube 3 and the chamber 7. The CPC powder 2500 is passed through the urine drainage tube 4 through the bag body 2 of the urinary bag system 1 configured as described above.
mg was put in and the slide clamp 9 was slid to close the urination tube.

(Example 2) CPC 2500 mg was added to 100
It is adjusted so as to be an aqueous solution of ml, and then put into a mold at 0 to 30 ° C. and pressed to evaporate water to form a block,
The block-shaped CPC 111 was fixed in the chamber 17 just below the connection port with the urine drainage tube 13, and then the urine drainage bag system 11 was produced in the same manner as in Example 1 (see FIG. 3).

Example 3 CPC powder 25 of Example 1
Benzalkonium chloride powder 310 in place of 00 mg
0 mg was enclosed.

(Embodiment 4) Block-shaped CP of Embodiment 2
C2500mg instead of benzalkonium chloride 310
As in Example 2, 0 mg was formed into a block and fixed in the chamber.

(Example 5) CPC powder 25 of Example 1
In place of 00 mg, 2300 mg of cetyltrimethylammonium chloride powder was enclosed.

(Embodiment 6) Block-shaped CP of Embodiment 2
Instead of C2500 mg, 2300 mg of cetyltrimethylammonium chloride was formed into a block as in Example 2 and fixed in the chamber.

Example 7 CPC powder 25 of Example 1
Instead of 00 mg, 3000 mg of trioctylammonium chloride powder was enclosed.

(Embodiment 8) Block-shaped CP of Embodiment 2
Instead of C2500 mg, trioctyl ammonium chloride 2300 mg was formed into a block shape in the same manner as in Example 2 and fixed in the chamber.

Comparative Example A commercially available urinary bag system (trade name: Uroguard closed type urine bag) manufactured by Terumo Corp. was used. The cross-sectional shape of the urine drainage tube lumen used in this urine drainage bag system is circular. The color development inhibitor described above is not enclosed in this urine bag system.

Using the urinary bag system thus produced, urine of a patient whose urinary indican concentration was about 190 mg / dl was used to visually observe the color of urine at 1 hour and 24 hours after urine collection. . As a result, in the examples, no change was observed in the color of urine 1 hour and 24 hours after the urine collection. In the comparative example, a clear color change was confirmed after 1 hour and 24 hours.
It was confirmed that the urine after 24 hours in the urine bag system of Comparative Example turned purple and the urine was colored.

Further, by bending 180 ° around the middle portion of the introduction tube used in the embodiment as a fulcrum, the urine indican concentration was about 190 mg / dl, and the fresh urine of the patient was 30 m.
When 1 was injected from one end of the urine drainage tube, urine flowed out from the other end of the urine drainage tube. As a result, urine did not remain in the urine drainage tube even if the urine drainage tube was kinked, and coloring was not observed.

Similarly, in the urinary guide tube of the comparative example, the middle part was bent by 180 °, and 30 ml of fresh urine of a patient whose urinary indica concentration was about 190 mg / dl was injected from one end of the urine guide tube. No urine leaked from the part bent at 180 ° to the other end. When the urine drainage tube was observed after 24 hours in this state, it was confirmed that the urine turned purple and the urine was colored. As described above, it is understood that the urine bag and urine bag system of the present invention do not change the color of urine even when the concentration of indican in urine is high.

[0052]

INDUSTRIAL APPLICABILITY According to the present invention, even when used in a patient with a high concentration of indican in urine, it is possible to suppress the color development due to the reaction of indican and to suppress the coloring due to indigo,
It can be used for a urine bag and a urinary bag system capable of observing the original color of urine.

[Brief description of drawings]

FIG. 1 is an overall view of a urine bag system according to the present invention.

FIG. 2 is a cross-sectional view taken along the line AA ′ of FIG.

FIG. 3 is an overall view of a urinary bag system according to a second embodiment of the present invention.

[Explanation of symbols]

1 Urinary bag system 2 bags 3 urinary tube 4 Urination tube 5 connection 6 Support rod 7 chambers 8 hydrophobic filter 9 slide clamp 10 Urinary tube storage 11 Urinary bag system 12 bags 13 Urinary tube 14 Urination tube 15 Connection 16 Support rod 17 chambers 18 Hydrophobic filter 19 Slide Clemme 23 Groove 110 Urinary tube storage 111 CPC block

Claims (13)

[Claims] 1. A urine bag containing a color development inhibitor for indican in urine. 2. The urine bag according to claim 1, wherein the color development inhibitor is a surfactant. 3. The urine bag according to claim 1, wherein the color development inhibitor is a cationic surfactant. 4. The quaternary ammonium salt or quaternary pyridinium salt having at least one organic group having 5 or more carbon atoms bonded to a nitrogen atom, wherein the color-suppressing agent is a quaternary ammonium salt or a quaternary pyridinium salt. The urine bag described. 5. The color development inhibitor is at least one selected from the group consisting of cetylpyridinium chloride, benzalkonium chloride, cetyltrimethylammonium chloride and trioctylmethylammonium chloride. The urine bag described. 6. A urine bag for storing urine, a urine guiding tube for introducing urine to one end of the bag, and a urine draining tube for discharging urine at the other end, and urine inside thereof. A urinary bag system characterized by containing a color-suppressing agent for indica in the bag. 7. The urinary bag system according to claim 6, wherein the color development inhibitor is a surfactant. 8. The urinary bag system according to claim 6, wherein the color development inhibitor is a cationic surfactant. 9. The color development inhibitor is a quaternary ammonium salt or a quaternary pyridinium salt having at least one organic group having 5 or more carbon atoms bonded to a nitrogen atom. The described urinary bag system. 10. The color development inhibitor is at least one selected from the group consisting of cetylpyridinium chloride, benzalkonium chloride, cetyltrimethylammonium chloride and trioctylmethylammonium chloride. Introduced bag system as described. 11. The urine bag system according to claim 6, wherein the urinary tract is secured even if the urine tube is kinked. 12. The urine drainage bag system according to claim 11, wherein the urine drainage tube has a groove portion arranged in a longitudinal direction on an inner wall of the urine drainage tube. 13. The bag, the urine drainage tube, and the urine drainage tube are made of EVA.
The urinary bag system according to any one of 1 to 12.