JP2002539857A - Hypodermic injection device and energy recharging station - Google Patents

Abstract

(57) Abstract: A subcutaneous injection device (1) for injecting an injection from at least one injection container (13), wherein the system (1) is used to push the injection from the container (13). A spring loaded carriage (57) for moving the plunger (59) through the container (13). A device is provided for resetting the spring (61) after completing the injection process.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION

CROSS REFERENCE TO RELATED APPLICATIONS This application is filed on March 25, 1999 under 35 USC 35,119 (e).
Claims priority of US Provisional Patent Application Ser.

[0002]

FIELD OF THE INVENTION

The present invention relates to a subcutaneous injection device, and particularly to an injection device in which an injection solution is held in a container and releases the injection solution from the container. The invention can be used in particular as a multi-channel injection device.

[0003]

[Description of the Prior Art]

Hypodermic injection devices are nowadays widespread around the world and used for both humans and animals. Furthermore, it is often necessary or helpful to have multiple simultaneous injections. To protect against various diseases, to provide as a single disease ingredient, to promote the health of humans and animals by adding vitamins and minerals, or to increase livestock milk production, Different substances can be injected to provide improved properties, such as administering an immunopharmaceutical component that promotes growth of the animal or inhibits the reproductive system of a meat animal, or for special medical treatment of humans (In the following description, it is called "injection solution"). For large numbers of people in Third World countries and large injection programs, such as injections of large numbers of animals, the ability to perform multiple injections simultaneously rather than sequentially can save a great deal of time. There will be. In a vaccination regimen, there are many advantages to giving multiple injections at the same time, such as for children who require more than three injections per visit, but to reduce the often occurring mental trauma. It would be very convenient to administer all vaccines at once. Also, there is a constant danger of needle sticks to physicians, nurses and others who make injections, and the threat of diseases such as HIV and AIDS, which must be avoided.

[0004] Injection devices used to deliver large numbers of injections to large groups of people, large numbers of animals, etc., even when the injection device must be filled with the appropriate amount of individual injection solution,
Whether the filled injection container is manually or otherwise slowly loaded and then placed into the injection device, the device is necessarily slowed down. There is a great need for an injection device, particularly a compound injection device, which can quickly and effectively fill an apparatus with an appropriate amount of injection solution to perform an injection treatment, and quickly refill the apparatus to continue the injection treatment. Similarly, there is a great need for a device of the above type that avoids sticking of the needle into the person performing the injection and that prevents the person from touching either the injection solution or the injection portion of the device during or after the injection procedure. .

[0005]

Summary of the Invention

An object of the present invention is to provide a subcutaneous injection device for efficiently and safely delivering an injection from a container holding the injection.

An object of the present invention is to provide a subcutaneous injection device that can prevent a needle from sticking to a person who performs injection.

It is another object of the present invention to provide an injection device which simultaneously performs at least two types of injections and further includes means for preventing a needle from sticking to a person not intended to receive the injection.

[0008] Yet another object of the present invention is to provide an injection device in which an injection liquid is held in a container having an injection orifice and the injection liquid enters the desired body through the injection orifice.

It is a further object of the present invention to provide an injection device for administering an injection from at least two cartridges.

[0010] A further object is to provide an injection device for providing an injection solution from at least two cartridges under jet pressure through the injection orifice of each cartridge.

It is another object of the present invention to provide an injection device having at least two cartridges with a perforator through which an injection flows.

It is another object of the present invention to provide an injection device having energy storage means for energizing the device to make an injection, and a motor-operable device for re-energizing the device quickly and economically. That is.

A further object of the present invention is to provide a cartridge injection device having a biasing means for feeding an injection solution from at least one cartridge into a body, wherein the biasing means is set in a cocking state by an electric motor. is there.

A related object of the present invention is to provide a motor operated injection device wherein an electric motor is held in a handle.

Still another object of the present invention is to provide an injection device having a biasing means for pushing an injection solution from a cartridge into a body, and a loading table for rapidly and economically applying energy to the biasing means. .

Another object of the present invention is to provide a container holding member for holding an injection container, the holding member being disposable after injection together with the container member, and providing physical contact or handling of the disposable part by a user. There is no need to provide a hypodermic injection device.

It is another object of the present invention to provide a hypodermic injection device that simultaneously injects the injectable solution from at least two cartridges that can be discarded after injection and that does not require physical contact or handling of the disposable part by the user. .

Another object of the present invention is to provide an injection device having a protective wall for injecting a fluid from at least one cartridge and preventing the injection liquid from scattering during an injection procedure.

It is a further object of the present invention to provide a hypodermic injection device for injecting an injection from at least one cartridge held in place by a pre-disposable plate.

[0020] Another object of the invention is to apply pressure to a cartridge to dispense an injection.
It is to provide a multi-cartridge injection device having one or more springs and a latch device for cocking and releasing the springs.

It is a further object of the present invention to provide a composite channel injection device in which injection means are provided in close proximity to safely and efficiently perform multiple multiple channel injections.

A further object of the present invention is a cartridge having a dispensing end with an orifice or perforator through which an injection can be dispensed, the injection holding part of the cartridge for dispensing the injection. It is to provide an injection cartridge having a movable plunger inside which can be moved.

It is a further object of the present invention to provide an injection cartridge that holds at least two components of an injection dosage.

A further object of the present invention is an injection device for a plurality of cartridges having a plunger for dispensing an injection solution therein, and further comprising a ram moving toward the plunger to push the injection solution out of the cartridge. The present invention provides an injection device having a carriage and a means for resetting the carriage to a cocking position.

Yet another object of the present invention is to provide a biasing means for dispensing an injection from at least one cartridge, wherein the biasing means is disposed and held at a cocking position according to a sensing signal indicating whether or not the cartridge is loaded therein. It is to provide a hypodermic injection device having

A general object of the present invention is to be able to use one or more injections at the same time, to be economical and fast to use for a large number of people or animals, and to prevent unwanted needle sticks. It is an object of the present invention to provide an improved hypodermic injection device that prevents a user from contacting potentially contaminated surfaces after an injection procedure.

From the following description and the appended claims, other objects and advantages will be apparent to those skilled in the art.

The above objective is accomplished according to a preferred embodiment of the present invention. In one preferred embodiment, a jet hypodermic injection device is provided that holds at least one cartridge that holds serum, vaccine or other injectable solutions. The cartridge preferably has a dosing end with an end portion having a channel with an outlet nozzle that is an orifice. A plunger is disposed within the cartridge and contains an injection between the plunger and the end portion. The end portion can also have a perforator instead of an orifice for the outlet nozzle. The apparatus includes a housing having a disposable front end plate with a hole having a holding surface for holding a front end of the cartridge. The housing contains a movable carriage with a ram that moves the plunger within each cartridge. The carriage is movable between a setting position and a dispensing position. One or more springs cause the carriage to inject injection fluid from each channel and outlet nozzle by moving the plungers within the cartridge by moving the ram from the set position where the springs are in the cocking position. It is moved or driven to a dispensing position that pushes it into the body. The spring is held in the cocking position by a releasable latch, which latches
It may be a solenoid piston that operates when a cartridge sensor sends a signal to the solenoid depending on whether the cartridge is loaded in the housing.

In a preferred embodiment, a cam driven by a motor allows the carriage to be moved from its dispensing position to the set position and to set the spring in a cocked state. A cam follower extends from the carriage, and the motor rotates the cam, so that the cam follower, and accordingly the carriage,
Move to set or cocking position.

The spring is preferably guided and positioned by a movable rod passing through the housing and extending between the carriage and the rear part of the housing. A securing member on the rod forms a shoulder that supports one end of the spring, and the other end of the spring is connected to an interior portion of the rear wall of the housing. As the carriage moves toward the set position, it moves each rod and compresses the spring to the cocking position.

The pre-plate holding each cartridge is removable or ejected from the injection device after use of the cartridge, whereby the plate is discarded with the used cartridge. This avoids needle sticks and the problem of injecting doctors, nurses or other health personnel contacting contaminated surfaces,
Dangerous and unauthorized use of used cartridges can also be ruled out.

In a preferred embodiment, the cam or other carriage reset device is moved from the final position to the initial position by a motor having a motor driven tool configured to rotate the cam or other device. A loading platform can be provided to reset the cam of one or more injection devices according to the present invention, and is preferably used when trying to load a new cartridge into the device. Alternatively, the housing can be held by a handle configured to have a motor and possibly a power supply for the motor. The device is ideal for injecting large numbers of humans or animals safely and rapidly and for single or multiple injections.

[0033]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Referring to FIGS. 1 and 2, a preferred embodiment of the present invention is shown. These figures show a hypodermic injection device 1 having a housing 3 and a handle 5. The housing 3 includes a front end or plate 7 having an injection trigger 9 and a front end release trigger 11. The trigger 9 can take the form of a rotatable lever, whereas the trigger 11 can be a push button. The device 1 is shown to perform six (sequence) injections simultaneously, as described below, but the number can be from one to N (ie, any number of injections). .

With particular reference to FIG. 2, an important advantage of the present invention is that the needle may be inadvertently touched by the injection portion of the device or the needle may be used by a piercer or nozzle when the outlet nozzle is used. In order to avoid the possibility of accidentally piercing the cartridge, the front end is made easy to dispose together with the used cartridge. This facilitates the elimination of cross-contamination and illness by both blood and injection fluid at the front end of the injection device. FIG.
Shows the injection device 1 after injection. The front plate 7 is an example of a holding member that holds the cartridge 13. Prior to injection, the front plate 7 holding the cartridge 13 is releasably locked in the housing 3 as shown in FIG. As will be described in more detail below, each cartridge holds a required volume of injection, often serum or vaccine. The front part of the cartridge 13 is held in the front plate 7, and the rear part of the cartridge is supported and held in the holding fixture 15.

When a user operates the front end trigger 11 after performing an injection from the cartridge loaded in the apparatus 1, the lock member 17 that has been in the groove 19 of the front plate 7 is retracted, and the lock member 17 is further moved. Is released by releasing the spring that is fitted in the engagement hole at the position 21, the front end 7 is pushed forward from the housing 3 together with the cartridge 13, and these members are thrown out of the housing 3 to cause contamination. The material is discarded into a container B configured to hold the object. No human or animal touches the front plate 7 or the cartridge 13 after the injection procedure or during disposal of the front plate 7.

The front plate 7 is shown in more detail in FIG. As mentioned above, the front plate 7 is one of many possible devices for holding an injection container such as a cartridge 13. The front plate 7 includes an outer front surface 23 and a rear extension 25 provided with grooves 19 on both sides. The front plate 7 is slid to a predetermined position so that the housing 3
Can be gripped by a lock member 17 fitted in a groove 19 near the front of the device, and these members 17 are retracted when the trigger 11 is actuated. Alternatively, the front plate 7 can be locked to the housing 3 (the front end of which forms a part) by removably inserting a lock slide or the like into the groove 19, and the locking member 17 is temporarily locked.
When the front plate is removed from the groove 19, the front plate can be dropped from the rest of the housing 3. The front end 7 further comprises a holding surface 3 for gripping the front end of the cartridge 13 which is preferably press-fit to hold the cartridge 13 in place.
1 with a hole 29. In order to ensure a firm grip, the outer surface of the cartridge 13 can have a high friction surface if necessary. In particular, a guard ring 33 is provided around each hole 29 to prevent blood or injection fluid from scattering when flowing through the outlet nozzle of the cartridge 13 during an injection procedure. For further protection against shattering, a further shattering ring 35 can be provided, as shown in FIG.

As described above, the front plate 7 or other holding member is disposable. To maintain the sterility of the front end, the front end is provided in a package that keeps it sterile. Sterile packaged cartridges can be filled at the site of the injection, but can also be filled with the selected vaccine and ready to be inserted into the front plate 7. Alternatively, the front ends can be provided with pre-inserted cartridges filled with the appropriate amount of each injection solution to be filled, all of which are placed in a sterile package at the front end holding them. Will be provided. It should be noted that the front end 7 can hold one cartridge, but can hold six or indeed any number of cartridges as shown. It is expected that no more than six injections will be given simultaneously for a variety of practical reasons, as described below.

FIG. 4 shows the front plate 7 loaded with six cartridges 13. Not every cartridge location need contain an injectable injectable solution. For this reason,
As mentioned above, the plate 7 has a rear extension 25 and grooves 19 on both sides.
The plate 7 can slide behind the removable locking member 17, which locks into the groove 19 and can be removed when the front plate 7 and the cartridge 13 are dropped from the housing 3 or pushed out. . Referring to the front part of the cartridge 13, the orifice 35 is an outlet part for two functional (active) channels, as shown in FIG. Penetrates. In a preferred embodiment of the present invention, the orifice is configured to route a jet of injection fluid from cartridge 13. Instead of the orifice 35, a perforator, for example of the order of 0.5 to 1.0 mm as disclosed in U.S. patent application Ser. No. 08 / 738,303, as shown in FIG. A perforator of length can also be used. By using a perforator, the injection pressure could be reduced and the amount of injection liquid remaining on the surface after injection could be reduced, if not eliminated completely. Experimental programs by the inventor have shown that perforators sometimes improve the efficacy and reduce impact trauma to the patient.

As mentioned above, six cartridge positions are shown. It has been described that any number of cartridges with each injection channel can be provided. However, protocols proposed by the Centers for Disease Control and Prevention (CDC) limit the number of child injections that can be performed on a single visit to a health care center to a maximum of four. As CDCs have more vaccines available, 1
It is clear that we feel that we may be able to increase the number of injections that are proposed to be given in a round. The size of the patient and where the injection site is located in the body will limit the volume of fluid that can actually be administered to the injection site. It is clear that this factor is different for children, adolescents and adults, for example, military personnel (often requiring large numbers of vaccinations when on duty or deployed in various parts of the world).

As in FIG. 4, the device shown in FIG. 5 does not require that all cartridges contain dispensable injections. Non-functional with no injection in the channel (
Other cartridges can be used, such as cartridges that are inactive, ie, loaded with dummy. Such non-functional cartridges can be marked with different colors or the like. In this case, FIG. 5 shows the perforator 36 in the functioning channel and the dummy cartridge 37 in the non-functioning channel.

FIG. 6 shows an injection liquid container having a suitable shape as the cartridge 13. The cartridge 13 has an outer wall 38 and an inner wall 39 forming a tube 41. The plunger 43 is slidable in the pipe 41, and in order to prevent leakage from the rear end,
A seal is provided on its outer periphery, which can also be formed, for example, from an elastomeric material such as a rubber compound, plastic, or glass with a rubber seal. The plunger 43 is dimensioned to fit on the inner wall 39 so as to seal the liquid. To further reduce leakage during injection, the plunger 43 may have two walled cylindrical portions 45 (forward) and 47 (backward). Plunger 43
Defines an injection solution holding portion 49 of the cartridge 13 between the orifice 35 and a front portion 51 of the cartridge 13 having a channel 53 terminating in the orifice 35. The front end portion of the cartridge 13 has a smaller diameter than the rear portion, and is preferably pressed into the front plate 7 as described above. When the cartridge 13 is pressed into the plate 7, the rear part of the front plate 7 is preferably engaged with the shoulder 55.

Depending on the situation, the cartridge 13 can be filled on-site or off-site. Further, the cartridge 13 can be pre-loaded into the holding member such as the front plate 7 at the place where the apparatus is used, but it can be performed at a place other than the site. When performed off-site, the cartridges can be filled and then sent to the loading station separately from the front plate, but are pre-loaded on the front plate (or other holding member) and provided in a sterile package. You can also.

The cartridge 13 can be configured for a lyophilized vaccine by providing two compartments separated by an easily breakable seal, such as the seal 56 shown in dashed lines. One compartment may contain a lyophilized vaccine, drug or serum, and the adjacent compartment may contain a suitable amount of fluid to mix therewith. Means for breaking the seal and mixing the contents when inserting the cartridge into the front plate 7 or when inserting the cartridge loading plate into the injection device may also be provided. Means for mixing the lyophilized vaccine in a cartridge at the time of injection is described in US Pat. No. 5,080,648.

Referring now to FIG. 7, this is a device 1 without the handle or trigger described above.
FIG. The device 1 has a housing 3 and an end plate 7 as described above. In order not to unnecessarily complicate FIG. 7, means for dropping or pushing the front plate 7 out of the injection device are not shown. Housing 3 houses carriage 57, from which a ram or plunger rod 59 extends. A set of three springs 61 (for each of the three cartridges shown, there are six cartridges and springs in device 1) circumscribe drive rod 63, each of which is a nut. That is, the movable spring receiver 65 is provided. The spring receiver 65 is
Movable along the threaded rod 63, the preloading of the spring
Therefore, it is a means for adjusting the injection pressure. The housing 3 has a rear wall 67, and the rear end of the spring 61 is in contact with the fixed wall 67. The wall 67 is provided with a set of holes 69 through which the rod 63 can move. A cap or shoulder 71 is provided at the rear end of the rod 63 to prevent the rod 63 from entering the interior chamber of the housing 3 and to cooperate with a latch assembly described below. The latch assembly includes solenoids 73 for each spring (but only two are shown), each of which is inserted energized in front of the cap 71 as part of the latch assembly. A piston 75 is provided. When the cartridge is mounted on the appropriate holding part of the housing 3, the cartridge sensor switch 79 closes, causing the piston 75 to retract from the path of the movable rod 63 and the cap 71. This is shown in the upper position of FIG.

As will be described below, a cam 81 is provided rotatably mounted on a shaft or axle 83 to reset the carriage assembly 57.
The cam follower 85 includes a follower arm 8 connected to the carriage assembly 57.
7 and a roller 89 that follows the shape of the cam 81.

FIG. 7 shows two cartridges 13 loaded in the two upper chambers 88 of the apparatus, but no cartridges are in the lower cartridge chamber 88. 2
One cartridge has a plunger 43. The front plate 7 has the protection ring 33 as described above.

FIG. 7 shows the injection device 1 after the injection has been performed. The carriage 57 is in the dosing position and has moved completely rightward to the front of the housing 3. The ram 60 presses the plunger 43 against the front end of the cartridge 13 to release the injection from the two functioning cartridges during the injection procedure. In order to reload the housing 3, the shaft 89 and the cam 81 are rotated clockwise by a motor (to be described later), so that the rollers 89 roll across the outer periphery of the cam 81, and the cam follower 85 and the carriage 57 are shown. 7 to the left.
The shape of the cam 81 is configured to perform this movement as the radius at the point of contact with the roller 89 increases. When the carriage assembly 57 moves to the left, the rod 63 is also pushed to the left. The nut 65 compresses the spring 61 until the cam 81 completes the rotation from the initial position to the final position, and when it reaches its final position, the spring 61 is fully compressed and the rod 63 is moved to the leftmost or rearmost position. It is in. At this time, the ram or drive rod 60 has been retracted from member 15 and it is convenient to remove the used front end from the injection device to create a space for inserting a new cartridge with an appropriate amount of injection solution into member 15. good. When cartridges 13 are properly installed, they again activate switch 79, thereby generating a sensing signal to move solenoid piston 75 away from the path of cap 71 on rod 63. Since no cartridge is inserted in the lower channel of FIG. 7, its piston 75 extends forward of the shoulder or cap 71, thereby preventing its spring from contributing to the injection process. .

To start the injection when the carriage assembly 57 is in the set position or cocking position and the spring 61 is also in the cocking position, the user of the device 1 activates the trigger 9. This action causes the mechanical latch (
As the roller 89 moves over the swoop portion 87 of the cam 81, the catch (not shown) is released or the cam 81 rotates slightly.
Can be free.

As the spring 61 pushes the rod 63 forward, the carriage assembly 57 moves, which drives the drive ram 60 toward the plunger 43 and pushes the injection solution through the channel 51 of the cartridge 13. , Exiting through an orifice 35 (or perforator 36). After the injection, when the user operates the trigger 11, the front plate 7 and the cartridge 13 are pushed out of the device and discarded, for example, into the barrel B.

Although not shown in detail, in a related embodiment, when the injection cartridges 13 are slid into the injection chamber, they actuate the connecting rods to allow the spring loaded latch 75 to be mechanically operated. And can be retracted to the unlatched position.

In some cases, the cartridge 13 may not be loaded in a part of the housing 3. In such a case, there is no cartridge 13 in the lower chamber and the lower rod 63 has not been released from its cocking or set position, as shown in the lower part of FIG. Should the cartridge not be present when the carriage 57 first moves to the left, the shoulder 71 can mechanically pass through the extended piston 75, but if the cartridge is not initially inserted into the channel, the right Cannot move through the extended piston 75 when moving.

In the embodiment of the invention shown in FIGS. 1 and 2, a motor and a power supply are housed in the handle 5 to reset the cam 81 to its initial position. FIG.
And devices such as that shown in FIG. 2 are portable and easy to use, and are particularly easy to use when injecting large numbers of humans or animals. Injection device 1 is small, lightweight and easy to handle, but can be used by healthcare staff to perform hundreds or thousands of injections all day.
When performing multiple human or animal injections, it may be advantageous in some circumstances to further reduce the size and weight of the hypodermic injection device according to the present invention. Thus, the preferred embodiments shown in FIGS. 8 and 9 form another aspect of the present invention.

FIG. 8 shows two hypodermic injection devices 1 according to the invention, in which case there is no handle. However, a loading table (loading station) for setting the carriage to the set or cocking position and for compressing or cocking the springs.
101 is provided. For this reason, as described above, the housing 3 is
1, a spring 61, and an injection chamber 88 for the cartridge 13. The loading table 101 includes compartments (partitions) 10 each receiving the injection device 1.
It has a series of walls defining 3, 105 and 107. Each compartment 10
3, 105, 107 include a hexagonal drive mechanism 109 that engages a corresponding portion of the cam axle 83. Preferably, an enable button 111 is provided, and when the device 1 is inserted into the compartment 103, 105, 107, the button 11 is activated.
Is pressed, causing the drive mechanism 109 to rotate the cam 81 to its fully loaded or ready for injection position. When the internal enable (disable) switch for detecting the appropriate amount of rotation is activated, the rotation of the drive mechanism stops. The position of these injection devices can also be sensed electronically without using a button switch as shown. Then, the device 1 shown in FIG. 8, which is a hand-held portion, is removed from the loading table 101 to perform injection. Then, the apparatus is reloaded and the loading table 101 is reset. The injection device 1 of FIG. 8 has the same shape as that shown in FIG. 1 (except for the absence of a handle), but an actual commercially available device will have a shape that a user can easily hold when performing an injection. .

The rear part of the device shown in FIG. 8 is shown in FIG. Power can be applied to the loading table 101 using the AC input unit 113 or the DC input unit 115. An on / off switch 117 is also provided. The power may be an AC grid or a battery, but may also be a compressed gas, an ignitable gas such as butane, a hydraulic drive, manual operation using a hand crank or foot pedal, or the like. The device 1 shown in FIGS. 8 and 9 can be easily moved when the injection procedure is completed. Health personnel do not need to lift the loading platform 101 when performing an injection. It only integrates the loading table 101 and the device 1 when spring compression is required, which replaces the direct contact interface as shown in FIGS. 8 and 9 with a long tachometer-type cable connection. Can also be used.
FIGS. 8 and 9 show the DC and AC power input units, but when power is abnormal or power cannot be obtained in a specific place, loading can be performed manually.

FIG. 7 shows a spring for each cartridge, but it is also possible to use a single spring. Other means of providing pressure to dispense the injection from the holding member are also possible. Other than wire springs, resilient plastic springs, elastomeric springs such as rubber or rubber-like materials, and possibly other springs including electromagnetic fields could be used. While the cam device shown in FIG. 7 has been found to be effective, other means of setting the device could be applied. For example, gear trains, linear gears such as those having linear gears, pawls and gear mechanisms, belts, rollers, etc. could be employed. Although the injection container is shown as being rigid, in some cases a flexible plastic holder may also be suitable.

Referring to FIGS. 10, 11 and 12, these relate to an analysis of the configuration of the outlet nozzle. The location of the exit nozzle is particularly important when simultaneous multiple injections into a child's limb limit the available surface area required for effective injection. Also, when performing simultaneous multiple injections, prevent or at least minimize overlap of the injections in the tissue to reduce the potential for adverse reactions if the injections are mixed in the target tissue of the child Is preferred. In order to achieve this non-overlapping condition, injections must be made at a certain minimum distance. For this reason, we performed a geometric analysis to determine the placement of the outlet nozzle that would prevent vaccine overlap in the tissue while using a minimal amount of surface area. To perform this analysis, an analysis of the volume of the tissue affected by the injection was required. Therefore, a six-channel device having a discharge volume of 0.2 cc in each channel was assumed. However, it was also found that the standard single dose was actually 0.5 cc. With multiple channel injections, it is possible to reduce the dose from the vaccine manufacturer. The arrangements we considered were rectangular, pentagonal with one orifice in the center, and hexagonal.

[0057] Pathological observations made by the present inventors during a study by the US Department of Agriculture show that the injection solution diffuses very little into the tissue when discharged by a needle and a syringe, that is, has a pooling effect. Was. The research showed that injection with a 0.2 cc needle and syringe occupies a 0.278 cc spherical volume of tissue (experimented). When injected by a jet gun, the spherical volume of the affected tissue is 8.79 times that of a needle and syringe used (experimented). Thus, the spherical volume occupied by 0.2 cc of injection delivered by a jet gun injection would be 8.79 times 0.278 cc, or 2.44 cc.

By taking the cube root of the result of dividing the volume by 0.5236, the diameter of the sphere D is obtained. Thus, a 0.2 cc jet gun injection occupying a 2.44 cc sphere would have a diameter of 1.67 cm. Using this diameter as the minimum allowable distance between each of the six outlet nozzles, analysis of the three configurations shows that the rectangular case occupies the minimum surface area at the injection location. Based on these calculations, a six channel rectangular housing is configured as shown in FIGS. 1, 2, 3, and 4. The results of these calculations are shown in FIGS.
Shows a rectangular arrangement, FIG. 10 shows a pentagonal arrangement, and FIG. 11 shows a hexagonal arrangement. FIG.
The arrow 121 of 0, 123 of FIG. 11, and 125 of FIG. 12 are each 1.67 cm. The arrow 127 in FIG. 11 is 1.96 cm. The results of the above research are shown in the following table. Orifice Arrangement and Surface Area Required to Prevent Overlapping of 0.2cc Six Shots Orifice Shape Surface Area (cm ² ) Rectangular 5.58 Pentagon 6.63 Hexagon 7.24 The present invention will be described in detail with reference to preferred embodiments. However, variations and modifications within the spirit and scope of the invention will occur to those skilled in the art to which the invention pertains.

[Brief description of the drawings]

1 is a view of the hypodermic injection device of the present invention, showing the front end with all six injection fluid cartridges having orifices for an outlet nozzle.

FIG. 2 is a view of the device shown in FIG. 1, showing release and disposal of a used front end portion of the device.

FIG. 3 is a view of a disposable front end of a preferred embodiment of the present invention.

FIG. 4 is a front end view of the present invention showing two central cartridges with orifices loaded at the front end and four outer cartridge locations loaded with a dummy.

FIG. 5 is a perspective view of an embodiment of the present invention, showing the position of two central cartridges having a punch and four outer cartridges loaded with a dummy.

FIG. 6 is a perspective view of a cartridge according to the present invention.

7 is a cross-sectional view of a preferred embodiment of the energy storage portion of the device shown in FIG.

FIG. 8 is a view of another preferred embodiment of the present invention, showing a loading platform for cocking the energy storage portion of the device.

9 is a view of a rear portion of the embodiment shown in FIG.

FIG. 10 is a schematic view of a dosing part for a 6-channel injection device according to the present invention.

FIG. 11 is a schematic view of a dosing section for a 6-channel injection device according to the present invention.

FIG. 12 is a schematic view of a dosing section for a 6-channel injection device according to the present invention.

[Procedural Amendment] Submission of translation of Article 34 Amendment of the Patent Cooperation Treaty

[Submission date] February 21, 2001 (2001.1.21)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claims

[Correction method] Change

[Contents of correction]

[Claims]

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0053

[Correction method] Change

[Contents of correction]

FIG. 8 shows two hypodermic injection devices 1 according to the invention, in which case there is no handle. However, a loading table (loading station) for setting the carriage to the set or cocking position and for compressing or cocking the springs.
101 is provided. For this reason, as described above, the housing 3 is
1, a spring 61, and an injection chamber 88 for the cartridge 13. The loading table 101 includes compartments (partitions) 10 each receiving the injection device 1.
It has a series of walls defining 3, 105 and 107. Each compartment 10
3, 105, 107 include a hexagonal drive mechanism 109 that engages a corresponding portion of the cam axle 83. Preferably, the button 1 1 Enable previously provided (Enable) button 111, the device 1 when inserted into the compartment 103, 105
1 is depressed causing the drive mechanism 109 to rotate the cam 81 to its fully loaded or ready for injection position. When the internal enable (disable) switch for detecting the appropriate amount of rotation is activated, the rotation of the drive mechanism stops. The position of these injection devices can also be sensed electronically without using a button switch as shown. Then, the device 1 shown in FIG. 8, which is a hand-held portion, is removed from the loading table 101 to perform injection. Then, the apparatus is reloaded and the loading table 101 is reset. The injection device 1 of FIG. 8 has the same shape as that shown in FIG. 1 (except for the absence of a handle), but an actual commercially available device will have a shape that a user can easily hold when performing an injection. .

[Procedure amendment]

[Submission date] October 19, 2001 (2001.10.19)

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] Name of invention

[Correction method] Change

[Contents of correction]

Title of the Invention Hypodermic injection device and energy recharging station

[Procedure amendment 3]

[Document name to be amended] Statement

[Correction target item name] Claims

[Correction method] Change

[Contents of correction]

[Claims]

──────────────────────────────────────────────────続 き Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE ), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN , IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW (72) Inventor Corvin Richard O United States of America New York 13027 Baldwinsville Connor's Road 1948 F-term (reference) 4C066 AA01 BB01 CC01 CC08 DD13 EE06 FF02 GG19 HH02 HH05 HH13 KK15 KK16 LL28 QQ48

Claims (47)

[Claims] 1. A subcutaneous injection device, comprising: a housing containing at least one injectable container for an injectable solution to be injected into the body from the device; A container holding member for holding the injection solution container in a predetermined position, and the holding member and the holding member for releasably latching the holding member to the housing during the injection procedure and for discarding after the injection procedure. A subcutaneous injection device comprising: a latch for releasing a container to be held; 2. The device according to claim 1, wherein the housing contains at least two injection solutions containers, and the disposable holding member is a structure having an opening for holding each of the injection solutions containers. 3. The device according to claim 2, further comprising a protective wall around said opening to prevent splashing of the injection liquid or blood during the injection procedure. 4. The apparatus according to claim 2, further comprising a scattering prevention wall provided around an outer edge of said container holding member to prevent the injection liquid from scattering during the injection procedure. 5. The device of claim 2, wherein said opening is dimensioned to press-fit said injection solution container to hold said container in place. 6. The housing has a front portion, the holding member has a front plate, and the latch and release means has a groove in one of the front plate and the housing. 2. The apparatus of claim 1, further comprising: a releasable latch member on the other of the front plate and the housing releasably engages the groove to latch the front plate to the housing. 7. An injectable injection release means for applying pressure to each of the injectable liquid containers for delivering the injectable liquid from the container for injection treatment, and a manual operation for activating the injection liquid discharge means. 3. Apparatus according to claim 2, including possible trigger means. 8. The injection liquid discharging means includes energy storage means for storing energy to be applied to each of the injection liquid containers, and the trigger means operates the storage means to store the energy. The apparatus of claim 7, wherein the energy storage means applies energy to each container to pump the injection from the container. 9. The energy storage means includes at least one spring and a latch for holding the spring in a set state, and the trigger means includes a release trigger for releasing the latch to initiate the injection procedure. The apparatus of claim 7 comprising: 10. The lock and release means comprises: at least one lock member for locking the holding member to the housing in cooperation with the container holding member; and releasing the lock member to connect the holding member to the housing. Means for activating the locking member to lock the appropriately positioned holding member to the housing, and the holding member and the respective containers held by the holding member. Discharging means for discharging air from the housing. 11. The holding member is a plate having a groove at a peripheral end, and the locking member is fitted in the groove to lock the plate to the housing and release the plate to release the plate. The device of claim 10, wherein a member is removable from the groove. 12. The subcutaneous injection device according to claim 1, further comprising at least two injection solution containers, wherein the holding member holds the containers in an appropriate position. 13. The injection solution container is a disposable cartridge, each of the cartridges includes an injection solution channel having an injection solution nozzle, and the holding member is configured to transfer the injection solution during the injection procedure to the respective channel. 13. A cartridge holder for holding the cartridge so as to dispense from the cartridge.
The described device. 14. The non-functional cartridge, wherein at least one of the cartridges is a non-functional cartridge configured to look like an injection channel but not functioning as a channel, wherein the non-functional cartridge is adjacent to the pseudo channel. 14. The apparatus of claim 13, wherein the surface which is visible from the outside is marked differently from the corresponding surface of the functional cartridge. 15. The injection solution container is a disposable injection solution cartridge, wherein the holding member has a cartridge holding surface for holding the cartridge at a predetermined position so that the injection solution can be administered, A liquid cartridge comprising: an outer wall having an inner wall surface defining an inner chamber; and a plunger fitted on the inner wall surface and movable in the chamber, wherein the plunger defines an injection solution holding portion of the chamber. The chamber has an injection dispensing end with an outlet nozzle, the dispensing end being configured to engage a respective one of the cartridge holding surfaces, and dispensing the injection during the injection procedure. 13. The device of claim 12, wherein the plunger can be moved into the injection fluid holding portion for dispensing from a cartridge through the respective nozzle. . 16. The injectable solution holding portion of at least one of the cartridges has a breakable seal dividing the holding portion into two compartments, one of the compartments holding a lyophilized portion of the injectable solution. 16. The device of claim 15, wherein the other of the compartments holds a volume of fluid for mixing the components of the injection solution. 17. The apparatus of claim 16, further comprising means for breaking said seal. 18. The apparatus of claim 1, further comprising biasing means for applying sufficient pressure to said respective containers to enable injection fluid to be ejected from the containers at a jet velocity. 19. The apparatus of claim 12, wherein the injection container is a six cartridge having an injection outlet, the outlet having three pairs of opposed outlets arranged in a rectangular array. 20. The device according to claim 12, wherein the injection solution container is a cartridge having a perforator for piercing the skin of the body and passing the injection solution during the injection procedure. 21. The apparatus according to claim 1, wherein the housing contains an injection solution container, and the disposable holding member is a structure having an opening for holding the injection solution container. 22. The device according to claim 21, further comprising a protective wall around said opening to prevent splashing of injection liquid or blood during the injection procedure. 23. At least two having a dispensing channel each having an outlet nozzle and a plunger moving therethrough to dispense an injection from a cartridge.
A subcutaneous injection device for dispensing an injection solution from two injection solution cartridges, the holding member holding each injection solution cartridge in a state where the administration channel is oriented in a common direction, and a movement member for each of the cartridges Ram means capable of moving the respective plungers so that the injection liquid can be pushed out of the cartridge through the dosing channel and the outlet nozzle; and moving the ram means with uniform pressure during the injection procedure A carriage movable from a set position to a dispensing position; a spring means movable from a cocking position to move the carriage from the set position to a dispensing position; and Moving the carriage from the dispensing position to the set position, and Apparatus comprising a carriage reset means, and a releasable latching means for latching said spring means cocking position cocking again. 24. Further, the holding member, the ram means, the carriage,
24. The apparatus of claim 23, including a housing containing said spring means, said latch means, said carriage reset means and said releasable latch means. 25. The apparatus of claim 24, further comprising a barrier near an outlet orifice to prevent splashing of the injection from the channel. 26. The apparatus of claim 23, wherein the carriage reset means includes a cam follower operably connected to the carriage, and a cam configured to move the cam follower and the carriage from a dosing position to a set position. Equipment. 27. A housing having a fixed wall for the spring means, the spring means having one end coupled to the fixed wall, and the other end moving to the cocking position when the carriage moves to the set position. 24. The apparatus of claim 23, comprising at least one possible spring, wherein said springs move said carriage from a set position to a dosing position in response to release of said latch means. 28. The spring means further includes a movable rod associated with each spring to guide and position the spring, the rod having a wall coupled to the other end of each spring. Wherein the carriage is movable as the carriage moves from the dispensing position to the set position, thereby moving the respective spring to a cocking position, wherein the latch means comprises a first latch extending from the housing. And a second latch member on the rod, wherein the first and second latch members include a first state for holding the rod and the respective spring in a cocking position, and a rod and the respective A second state in which the springs are released, after which the respective spring moves the carriage assembly to the dispensing position. The apparatus of claim 27. 29. The carriage assembly reset means, comprising: a cam follower operably connected to the carriage; and a movable follower from an initial position to a final position, wherein the carriage is reset from a dosing position to a set position by moving the cam follower. And a cam configured to move the cam from the final position to the initial position, and release the latch means to move the spring means from the cocking position to the carriage. 24. The apparatus of claim 23, further comprising: a trigger that allows movement of the device from the set position to the dosing position. 30. A solenoid, further comprising a solenoid for releasing the latch of the spring means by releasing the first latch member in response to the sensing signal.
The described device. 31. The carriage reset means, comprising: a carriage reset device operable to move the carriage from a dispensing position to a set position; and a drive device movable to operate the reset device. 24. The device of claim 23, wherein the drive is configured to be moved by a device driven by a correspondingly structured motor. 32. The carriage reset device, wherein the carriage reset device is a cam follower for moving the carriage from the dispensing position to the set position, the driving device is a cam operably connected to the cam follower, Rotatable by a motor, and configured to move the cam follower and the carriage from the dispensing state to the set position, wherein the latch means is responsive to the carriage moving to the set position. 32. The device of claim 31, wherein said spring means is latched in said cocking position. 33. A housing for accommodating said holding member, said ram means, said carriage assembly, said spring means, said carriage assembly reset device, said driving device and said releasable latch means, further comprising: An attached handle, the handle being driven by the motor to engage the drive to actuate the carriage reset device to move the carriage from the dosing position to the set position. 32. The device of claim 31, comprising: a movable tool for causing the motor to move; and a power input device for supplying power to the motor. 34. A housing accommodating said holding member, said ram means, said carriage, said spring means, said carriage reset device, said drive device and said releasable latch means, and cooperating with said housing. A loading table for operating the carriage reset device, wherein the loading table engages the motor and the driving device to operate the carriage reset device to move the carriage from the dispensing position to the set position. 32. The apparatus of claim 31, comprising: a movable tool for moving. 35. The apparatus further comprising sensing means for generating a sensing signal to indicate the presence or absence of at least one cartridge held by the holding member, wherein the releasable latch means is responsive to the presence or absence of the sensing signal. 24. The device of claim 23, wherein said device operates. 36. A hypodermic injection device having a mechanical energy storage device for releasing stored energy when performing an injection, and having an input mechanism for cooperating with an energy re-applying mechanism. A station for recharging energy, comprising: an energy transfer device for transferring energy from an energy source; and an energy recharging mechanism for transferring energy from the energy transfer device to the input mechanism of the energy storage device. An energy recharging station wherein a recharging mechanism cooperates with the input mechanism to transfer energy from the energy transfer device to the mechanical energy storage device. 37. The injection device has a predetermined external shape; the input mechanism has a drivable surface for receiving energy stored in an energy storage device; The station according to claim 1, comprising a drive surface that cooperates with the driveable surface to re-energize the energy storage device of the injection device. 38. The input mechanism has a cam mounted on an axle; the drivable surface is a surface of the axle; and the drive surface of the energy reapplying mechanism contacts the drivable surface. 37. A device for rotating the cam by rotating the axle as described above.
The mentioned station. 39. The injection device has a predetermined external shape, the station is provided with at least one mounting device for receiving and supporting the injection device, and wherein the driving surface is provided on the injection device. 38. The station of claim 37, wherein the station cooperates with the drivable surface to re-energy the energy storage device of the injection device. 40. The apparatus of claim 39, wherein the energy storage device of the injection device is at least one spring, and wherein the reenergizing mechanism cocks the spring. 41. The injection device further includes a rotatable cam that activates the device to cock the spring, the driveable surface being coupled to the cam, the drive surface being coupled to the driveable surface. 41. The station of claim 40, wherein the station cooperates to rotate the cam to cock the spring. 42. The injection device includes a device for receiving a disposable cartridge holding the injection solution, and further holding the injection device and transferring a new cartridge containing the injection solution to the injection device. 40. The station according to claim 39, comprising a support device for loading. 43. The energy recharging mechanism includes a manually operable member for transmitting energy from an operator to the mechanical energy storage device.
The station according to 6. 44. The rechargeable mechanism includes a compressed gas operable member for transferring energy from a compressed gas to the mechanical energy storage device.
The station according to 6. 45. The station of claim 36, wherein the energy reapplying mechanism includes a hydraulically operable member for transmitting energy from a device for applying pressure to a hydraulic fluid to the mechanical energy storage device. 46. The station of claim 36, wherein said energy recharging mechanism includes an ignitable gas operable member for transmitting ignition energy to said mechanical energy storage device. 47. The station of claim 36, wherein said energy recharging mechanism includes an electrically operable member for transmitting electrical energy to said mechanical energy storage device.