JP2002521138A - Bag or bag system for collecting and storing blood and method therefor - Google Patents

Abstract

SUMMARY OF THE INVENTION The present invention provides at least two primary storage chambers and at least two primary storage chambers, each of which is positioned relative to one another such that each of the storage chambers can be hermetically closed from the other storage chambers. A bag or bag system for collecting and storing blood, having a secondary storage chamber, and a method for collecting and storing blood.

Description

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to a bag or bag system for collecting and storing blood and a method for collecting and storing blood.

[0002] It is well known to collect blood from humans and store it in a frozen state for later use during surgery, blood transfusion, and the like. For this purpose,
A number of different blood bags have been provided.

[0003] In the past years, it has been found that blood from the umbilical cord and placenta at birth contains stem cells, cells that are present in the blood only at this special time of life. These cells have shown considerable potential therapeutic value, such as for use in bone marrow replacement procedures in cancer treatment or other immunodeficiencies.

To preserve these cells, blood from the umbilical cord and / or placenta, which is otherwise discarded, is collected and stored at low temperatures. The container used in this procedure is known as a conventional blood bag, as described above.

However, it is necessary to thaw the whole blood in order to obtain a specimen from a bag with frozen blood, and once thawed it must be used within a short time or discarded No, because this blood cannot be re-frozen. The problem with conventional bags and methods, therefore, is that there is only one opportunity to use stem cells to treat a patient.

[0006] Japanese Patent No. 10000224 discloses a bag system for separating stem cells and progenitor cells from umbilical cord blood by centrifugation. This system, consisting of six bags with connectors and tubing to direct blood from bag to bag, has one bag and the collected leukocyte components containing the aforementioned cells are frozen. The problem with this bag, however, is the same. This is because it is impossible to thaw a part of a cell without destroying the rest of the cell.

[0007] It is therefore an object of the present invention to provide a solution to the above-mentioned problem, in particular to allow only a part of the stored blood to be thawed, in particular umbilical cord blood and / or blood from placenta And a bag system for collecting and storing the blood.

The present invention relates to a bag or bag system for collecting and storing blood according to claim 1, and a bag for collecting and storing blood in combination with a mixing bag according to claim 4. Or collecting the blood according to claim 5, or a bag system,
Bag or bag system for mixing and storing.

The bag or bag system of the present invention includes a storage chamber only system with only an opening for receiving blood, or an opening for receiving blood,
It may have an inlet channel. This inlet channel may be, for example, a small tube suitable for being connected to a snap lock or clamp or similar easily operable closure device.

[0010] Another aspect of the invention is a bag or bag system for collecting and storing blood in combination with a mixing bag, the mixing bag comprising at least one mixing chamber, an opening for receiving blood. , And an opening for discharging blood.
For a mixing bag, the opening for receiving blood and the opening for discharging blood may be the same. The opening for discharging blood can be connected to an opening for receiving blood into a bag or bag system for collecting and storing blood, for example by using a suitable connector.

[0011] One further aspect of the invention is a bag or bag system for collecting and storing blood, having a mixing chamber, said mixing chamber closing, for example, a snap lock or closing a clan. It can be hermetically closed from the storage chamber by use or by welding. To minimize the amount of equipment stored, the mixing chamber is preferably hermetically closed from the storage chamber and arranged to be removed prior to storage.

[0012] The mixing chamber of the bag or bag system of the present invention must have a volume equal to or greater than the sum of the volumes of the primary and secondary storage chambers. In order to use a mixing chamber for mixing blood with an anticoagulant and / or a preservative, the mixing bag may have a volume at least twice the combined volume of the first and second storage chambers. preferable. The mixing chamber is, for example, 1
00 to 500 ml, preferably 225 to 400 ml, more preferably 250 to 3
It has a volume in the area of 00 ml. In one preferred embodiment, the mixing chamber has a volume in the region of, for example, 100-500 ml, preferably 125-400 ml, more preferably 150-250 ml.

[0013] The mixing chamber may further comprise at least one port for injecting an anticoagulant and / or a capture agent, and / or withdrawing blood for testing, for example, to detect contamination by a virus. May have at least one port.

[0014] In all of the foregoing bags, the primary and secondary chambers are in fluid communication with each other. This liquid communication is preferably between 10 and 20 mm, preferably between 12 and
It is formed by pipe connections having a length in the region of 15 mm. In another embodiment, the pipe connection has a length in the region of 10-300 mm, preferably about 100 mm.

The inner diameter of the pipe connection is 2 to 10 mm when the pipe is not crushed,
Preferably it is in the region of 3-8 mm, more preferably 4-6 mm.

[0016] Immediately after the filling is completed, (by heat welding, impulse welding, etc.)
It is important to ensure that only a minimal amount of collected blood is destroyed by welding or by closing with a snap lock or clamp. The bag or bag system of the present invention, comprising the aforementioned pipe connection containing only a minimal amount of blood, only a very small percentage of the total amount of blood is damaged, for example in connection with closing these channels by heat. Guarantee that

By using the bag or bag system of the present invention to store umbilical cord blood, at least two, preferably at least five, more preferably at least eight, primary storage chambers, and most preferably at least It is possible to obtain ten primary storage chambers, all of which contain blood. Of course, the number of chambers filled with blood will depend on how much blood can be removed from the umbilical cord and placenta, and how the blood bag is designed.

The volume of the primary storage chamber is usually between 10 and 40 ml, preferably between 25 and 35
ml, more preferably in the region of 25-30 ml. In another embodiment,
The volume of the primary storage chamber is in the region of 10-80 ml, preferably 25-70 ml, more preferably 25-50 ml.

However, it is preferred to have as many storage chambers as possible. because,
This gives the patient maximum flexibility when using stored blood. Any number of chambers filled with blood can be removed from the bag, so that only the amount of blood needed for the intended treatment can be thawed.

The system of chambers also has a number of storage chambers, preferably at least equal to the number of primary storage chambers, all of which are individually closed and removed as maintenance chambers It is possible. The purpose of these secondary chambers is to provide a small volume of blood for testing purposes. Thus, the ratio between the volume of the primary storage chamber and the volume of the secondary storage chamber is
Preferably, it is 40: 1 to 60: 1, more preferably about 50: 1. In another embodiment, the ratio between the volume of the primary storage chamber and the volume of the secondary storage chamber is 40: 1, preferably 50: 1 to 80: 1.

The secondary storage chamber is 0.2-1.5 ml, preferably 0.3-0.7 ml,
More preferably, by having a volume in the region of 0.4-0.6 ml, the required amount of blood, e.g. Obtaining eliminates the need to thaw a larger volume of blood than one or two secondary storage chambers. This particular feature is important because it determines the quality of blood to find the right amount needed for treatment, to test for blood contamination (eg, bacteria), or to perform genetic testing. It is important to do so.

In one preferred embodiment, all primary storage chambers are marked or can be individually marked, each primary storage chamber having at least one secondary storage. It corresponds to the chamber. Furthermore, the bag or the bag system itself is preferably marked or can be marked with a date and / or number to enable the bag to be identified.

The primary storage chamber can have a variety of shapes, but a preferred embodiment is that the shape is such that when the bag or bag system is in a collapsed state,
A substantially square or substantially round embodiment.

Long term storage of blood involves applying a temperature below -170 ° C. to the bag or bag system so that the bag or bag system is made of a suitable material, such as medical or pharmaceutical grade. Consisting of Examples of suitable materials are, for example, polyethylene, ethylene-vinyl acetate copolymer, fluoroplastic, polyimide, silicone, ABS polymer (acrylonitrile / butadiene / styrene polymer) or polycarbonate.

The bag or bag system may consist of one or more foil layers joined, for example by welding, and in the case of two or more foil layers, the material of the layers is selected from the aforementioned materials, They can be the same or different.

In one preferred embodiment of the invention, the bag system has primary and secondary storage chambers made of one of the aforementioned materials, wherein the bag system is made of, for example, a suitable material By surrounding the bag system with a second bag, it can be located or located within the second bag. Second
May be divided into a number of fractions.

The present invention provides a method for collecting and storing umbilical cord blood and / or blood from the placenta, comprising: a) removing blood from the umbilical cord and / or placenta; Directing the blood into a mixing chamber; c) mixing the blood with a preservative and / or anticoagulant; d) optionally storing the blood for up to 24 hours; e) selecting Optionally, adding additional chemicals to prepare blood for cryopreservation; and f) forming a liquid communication between said mixing chamber and a number of storage chambers, wherein: Allowing the blood mixture to flow into the storage chamber; and g) closing the bag or bag system with a clamp, optionally Removing the chambers; h) closing the channels between the various chambers, for example by welding or closing by snap locks or clamps, whereby a number of said primary and secondary The storage chambers are hermetically closed from one another; i) immediately placing the bag or the bag system in a refrigerator, for about -7
Bringing the primary storage chamber and the secondary storage chamber into a storage bag or bag system, wherein the channels are connected to each other by an intermediate seal; The method also relates to a method wherein the volume of the secondary storage chamber is greater than the volume of the secondary storage chamber.

It should be noted that steps e) to i) can be performed after storing the blood for up to 24 hours, for example in a refrigerator, under conditions in which no bacteria grow.

[0029] Withdrawing blood from the umbilical cord and directing the blood into the mixing chamber can be performed in any conventional manner. Preferably, the removal of blood must be performed in a manner accepted by those skilled in the art.

The anticoagulant and / or preservative can be added after the blood is introduced into the mixing chamber, but preferably, the anticoagulant and / or preservative is Is already present in the chamber at the time it is introduced, which simplifies the method, since the mixing chamber can be prepared for use beforehand.

However, in the special case of low blood intake, preferably the anticoagulant and / or preservative is added after the blood has been collected. This is because this guarantees that the ratio between blood and the aforementioned drug is in the best possible range. Thus, in one preferred embodiment, the mixing chamber is provided with one special port, which facilitates the addition of anticoagulants and / or preservatives.

After mixing the blood with the aforementioned drugs, the mixing chamber is, in the present invention, in fluid communication with the storage chamber of the bag or bag system. Depending on what type of bag this connection is made by using tubing and connectors, or, in one preferred embodiment of the invention, simply between the mixing chamber and the storage chamber This can be done by opening the snap lock.

This allows blood to flow into the primary and secondary storage chambers, and after filling as many chambers as possible with the blood, the opening for receiving the blood may be, for example, a clamp or a snap lock. It is closed by using.

Since it is not necessary to store the installed empty mixing chamber, preferably
The mixing chamber is removed, for example, by cutting the mixing chamber or by removing the tubing or connector used.

In order to obtain a large number of chambers which can be removed individually, the fluid communication between the chambers must be closed tightly. This is preferably done by using heat.

Finally, the bag or bag system is frozen to a temperature below about -70 ° C.
This ensures that the blood can be stored until the blood needs to be used.

Various embodiments of the present invention will be described below with reference to the drawings.

FIG. 1 shows a bag according to the invention having a mixing chamber 1 with a double weld 5 and an inlet 11 with a tube 3, one end of which is connected to a needle for cutting blood. The connector 4 is provided. Two snap locks 4 and 6 are respectively mounted on the inlet 11 and the outlet 12 of the mixing chamber 1 respectively. A storage bag 13 connected to the mixing chamber 1 via a tube 14 with a clamp 7 is connected to the ten primary storage chambers 8 and the ten primary storage chambers 8 in fluid communication with one another via a pipe connection 10. And a secondary storage chamber 9. Dashed lines indicate that the bag or bag system will seal each chamber closed after the bag is filled with blood.
Indicates the location to be welded.

If, using the bag of FIG. 1, blood is introduced into the mixing chamber 1, which preferably already contains the above-mentioned necessary chemicals, the snap lock 2 is closed and the bag is Turn upside down or shake to mix. Then the snap lock 6 is opened and the blood mixture flows into the storage bag 13 and
Fill as many primary storage chambers 8 and secondary storage chambers 9 as possible.
To ensure that the blood mixture flows properly into the chamber, the person handling the bag can preferably slightly squeeze or shake the bag to facilitate the flow of the blood mixture. .

When all of the blood mixture contained in the mixing chamber 1 flows into the storage bag 13, the clamp 7 is closed and the mixing chamber 1 is cut off. The pipe connection 10 is then closed shortly after the bag is filled, or at least shortly before the bag is frozen, for example by welding. Welding may be performed by the use of suitable welding equipment, or by placing the bag at a temperature at which almost no bacteria can grow for up to 24 hours, during which time welding may take place. If it can be transported to a facility where possible, it can be done on site.

FIG. 1 shows one preferred embodiment of a bag according to the invention, wherein the mixing chamber is part of this bag. In such a bag of the present invention in which a mixing chamber is included as part of the bag, the risk of infection is minimized, since once blood is introduced into the bag, for example, one This is because there is no chance that unnecessary contact with the surroundings may occur, such as when transporting from one bag to another. This bag also ensures that only a minimal amount of blood is lost or destroyed during the process of collecting and storing blood. This is especially important if the blood volume obtained from the umbilical cord and placenta is very small.

As shown in FIG. 1, the primary storage chamber and pipe connections form a particular pattern. However, this is only one example of a pattern, and many other patterns are suitable, such as those shown in FIGS.
The important point is that the pattern is designed to allow filling as many storage chambers as possible, even when only a small amount of blood is available.

FIG. 2 shows a storage bag according to the invention with an opening for receiving blood 21, comprising a snap lock 22 and a clamp 23. The bag comprises twelve primary storage chambers 24 and twelve secondary storage chambers 25, which are in fluid communication with each other via pipe connections 26. The dashed lines indicate where the bags are welded to seal and close each chamber after the bags are filled with blood.

[0044] The bag can be connected to a mixing bag, and the ingested blood is mixed with the aforementioned drugs.

FIG. 3 shows a mixing bag 31 and a storage bag 35 of the present invention. Mixing bag 31
Comprises a mixing chamber 32 surrounded by a double weld 33 and comprises a connector 34 connectable to a storage bag 35. A storage bag 35 provided with an opening for receiving blood 36 with a snap lock 37 and a clamp 28,
It has ten primary storage chambers 37 and ten secondary storage chambers 40 that are in fluid communication with each other via a pipe connection 41. Dashed lines indicate where the bag is welded to fill each chamber after it has been filled with blood.

FIG. 4 shows a means 51 for suspending the mixing chamber on a suitable stand or similar means, an opening for receiving or discharging blood 42, and injecting and / or injecting additives for testing. It has one additional port 43 for withdrawing blood. The bag system further comprises four primary storage chambers 4 in fluid communication with each other and with the mixing chamber via pipe connections 46 and connectors 45, 49.
8 and two secondary storage chambers 50 for each primary storage chamber. Each primary storage chamber can be hermetically closed from each other and from the mixing bag using clamps 47.

When using the bags of FIGS. 2, 3 and 4, blood is also introduced into the mixing bag and processed as described above, with the difference that the mixing chamber forms part of the storage bag. Rather than being provided as a separate bag. A separate mixing bag,
After being connected to the storage chamber, blood flows into the primary and secondary storage chambers, as described above. When the storage chamber is filled, the mixing bag is disconnected from the storage bag and the storage bag is handled as described above.

When using the bag system of FIG. 4, the primary and secondary storage chambers are disconnected from the mixing chamber and optionally after being disconnected from the pipe connection by simply disconnecting the pipe connection. Preferably, they are located in one separate bag. The bag is composed of one or more compartments, each compartment suitable for containing one or more primary storage chambers and a secondary storage chamber connected to the storage chamber. The compartments can be separated by welding.

In all four figures, the secondary storage chamber has a generally square shape. However, this is only one example, and other shapes may be suitable as well.

Although the primary and secondary storage bags of the bag each appear to have the same size and shape, the size and shape of the primary and secondary storage chambers of the bag, respectively, can be different from each other. It is possible.

As shown in FIGS. 1 and 3, the mixing chamber is preferably provided with a double weld, but other embodiments, such as triple welds, or double thin films and single welds And the like are similarly possible.

An alternative embodiment of the storage chamber is shown in FIG. 5, where the primary storage chamber 61 is connected via a connector 63 to a secondary storage chamber 65, which stores blood. After being filled, they are hermetically closed from each other and from the primary storage chamber by the clamping members 62. Clamp 64 is used to hermetically close the storage chamber from the pipe connection.

[Brief description of the drawings]

FIG. 1 shows one preferred embodiment of a bag of the invention having a mixing chamber.

FIG. 2 shows a bag according to the invention, which can be connected to a mixing bag.

FIG. 3 shows a bag in combination with the mixing bag of the present invention.

FIG. 4 shows a bag system of the invention with a mixing chamber.

FIG. 5 shows another embodiment of a storage chamber as part of the bag system of the present invention.

[Procedural Amendment] Submission of translation of Article 34 Amendment of the Patent Cooperation Treaty

[Submission date] July 12, 2000 (2000.7.12)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0006

[Correction method] Change

[Correction contents]

[0006] European Patent Application No. 0790051 discloses a flexible plastic container. This container has at least four compartments. Each compartment has its own inlet opening. The outlet allows the liquid to enter the intestine or any other way into the body. The compartments are connected to each other by a valve, which can be opened from the outside. By selectively opening these valves, the liquids of the compartments can be completely mixed. JP 100002224 discloses that stem cells and progenitor cells are obtained from umbilical cord blood by centrifugation. A bag system for separating is disclosed. This system, consisting of six bags with connectors and tubing to direct blood from bag to bag, has one bag and the collected leukocyte components containing the aforementioned cells are frozen. The problem with this bag is, however, the same, because thawing some of the acidity will inevitably destroy the rest of the cells.

[Procedural Amendment] Submission of translation of Article 34 Amendment of the Patent Cooperation Treaty

[Submission date] October 4, 2000 (2000.10.4)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claims

[Correction method] Change

[Correction contents]

[Claims]

──────────────────────────────────────────────────続 き Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE ), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SL, SZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR , BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS , JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW

Claims (26)

[Claims] 1. A bag or bag system for collecting and storing blood comprising an opening for receiving blood, at least two primary storage chambers, and at least two secondary storage chambers. Wherein the primary storage chamber is in fluid communication with each other, and each of the storage chambers is disposed relative to each other so as to be hermetically isolated from other chambers; A bag or bag system wherein the volume of the chamber is greater than the volume of the secondary storage chamber. 2. The bag or bag system of claim 1, wherein the opening for receiving blood comprises an inlet channel. 3. The bag or bag system of claim 2, wherein the inlet channel is formed in a shape suitable for connecting to an opening in a mixing bag. 4. A bag or bag system for collecting and storing blood in combination with a mixing bag, wherein the bag for collecting and storing blood is defined in claim 1, The bag comprises at least one mixing chamber;
An opening for receiving blood and an opening for discharging blood, the opening for discharging blood for receiving blood in a bag or bag system for collecting and storing blood. A bag or bag system that can be connected to the opening. 5. A bag or bag system for collecting, mixing and storing blood comprising an opening for receiving blood and a mixing chamber, said mixing chamber comprising at least two primary chambers. A storage chamber and at least two secondary storage chambers in fluid communication, wherein the primary storage chamber and the secondary storage chamber are in fluid communication with each other, and wherein each of the storage chamber and the mixing chamber is Bag or bag system, positioned relative to each other so that they can be hermetically closed from other chambers. 6. The method according to claim 1, wherein said liquid communication is formed by a pipe connection.
A bag or bag system according to any one of the preceding claims. 7. The pipe connection is 10-20 mm, preferably 12-15 mm.
7. A bag or bag system according to claim 6, having a length in the region of mm. 8. The pipe connection may be 10 to 300 mm, preferably about 10 mm.
A bag or bag system according to claim 6 or 7, having a length in the region of 0 mm. 9. The pipe connection in an uncollapsed state having an inner diameter in the region of 2 to 10 mm, preferably 3 to 8 mm, more preferably 4 to 6 mm. A bag or bag system according to claim 1. 10. The mixing chamber is positioned relative to the storage chamber such that the mixing chamber is hermetically closed from the storage chamber and can be removed prior to storage. A bag or bag system according to any one of claims 1 to 9. 11. The primary storage chambers are individually marked or can be individually marked, each primary storage chamber corresponding to at least one secondary storage chamber. , Claims 1 to 10
A bag or bag system according to any one of the preceding claims. 12. The bag according to claim 1, wherein the bag or the bag system comprises at least five primary storage chambers, preferably at least eight storage chambers, more preferably at least ten storage chambers. A bag or bag system according to any one of the preceding claims. 13. The ratio between the volume of the primary storage chamber and the volume of the secondary storage chamber is between 40: 1 and 150: 1, preferably between 50: 1 and 80: 1.
A bag or bag system according to any one of the preceding claims, wherein 14. The ratio between the volume of the primary storage chamber and the volume of the secondary storage chamber is between 40: 1 and 150: 1, preferably between 50: 1 and 80: 1.
14. A bag or bag system according to any one of the preceding claims, wherein 15. The volume of said mixing chamber is in the region of 100-500 ml, preferably 225-400 ml, more preferably 250-300 ml.
A bag or bag system according to any one of claims 4 to 14. 16. The volume of the mixing chamber is in the region of 100-500 ml, preferably 125-400 ml, more preferably 150-250 ml.
A bag or bag system according to any one of claims 4 to 15. 17. The method according to claim 1, wherein the volume of the primary storage chamber is in the region of 10 to 40 ml, preferably 25 to 35 ml, more preferably 25 to 30 ml. A bag or bag system according to claim. 18. The method according to claim 1, wherein the volume of the primary storage chamber is in the region of 10-80 ml, preferably 25-70 ml, more preferably 25-50 ml. A bag or bag system according to claim. 19. The volume of the secondary storage chamber is 0.2-1.5 ml,
19. A bag or bag system according to any one of the preceding claims, preferably in the region of 0.3-0.7 ml, more preferably 0.4-0.6 ml. 20. The method of claim 1, wherein the shape of the primary storage chamber is substantially rectangular when the bag or the bag system is in a collapsed condition. A bag or bag system according to paragraph. 21. The method according to claim 1, wherein the shape of the primary storage chamber is substantially round when the bag or the bag system is in a collapsed state. A bag or bag system as described. 22. The method according to claim 4, wherein the mixing chamber further comprises at least one port for withdrawing anticoagulants and / or preservatives for injection and / or testing. A bag or bag system according to any one of the preceding claims. 23. A bag or bag system according to any one of the preceding claims, wherein the bag or the bag system is made of a medical or pharmaceutical grade material. 24. The material may be selected from the group consisting of polyethylene, ethylene vinyl acetate copolymer, fluororesin, polyimide silicone, ABS polymer (acrylonitrile / butadiene / styrene copolymer or polycarbonate). 24. A bag or bag system according to claim 23. 25. A method for collecting and storing umbilical cord blood and / or blood from the placenta, comprising: a) removing blood from the umbilical cord and / or placenta; and b) removing the blood, eg, by infusion. Directing into a mixing chamber; c) mixing the blood with a preservative and / or anticoagulant; d) optionally storing the blood for up to 24 hours; e) optionally. Adding additional chemicals to prepare blood for cryopreservation; and f) forming a liquid communication between said mixing chamber and a number of storage chambers, said blood mixture comprising: Allowing the fluid to flow into the storage chamber; and g) closing the bag or bag system with a clamp, and optionally, the mixing chamber. And h) closing the channels between the various chambers, for example by welding or closing by snap locks or clamps, whereby a number of said primary and secondary storage The chambers are hermetically closed from each other; i) immediately placing the bag or the bag system in a refrigerator for about -7
Bringing the temperature below 0 ° C., wherein the primary storage chamber and the secondary storage chamber are arranged in a storage bag or bag system, wherein the channels are connected to each other by an intermediate seal; The method, wherein the volume of the primary storage chamber is greater than the volume of the secondary storage chamber. 26. The method according to claim 25, wherein the bag or the bag system is according to any one of claims 1 to 24.