JP2002519394A5 - - Google Patents
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- Publication number
- JP2002519394A5 JP2002519394A5 JP2000557884A JP2000557884A JP2002519394A5 JP 2002519394 A5 JP2002519394 A5 JP 2002519394A5 JP 2000557884 A JP2000557884 A JP 2000557884A JP 2000557884 A JP2000557884 A JP 2000557884A JP 2002519394 A5 JP2002519394 A5 JP 2002519394A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- derivative
- gdf
- mammal
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 96
- 102000012946 Growth Differentiation Factor 1 Human genes 0.000 description 87
- 108010090296 Growth Differentiation Factor 1 Proteins 0.000 description 87
- 239000012634 fragment Substances 0.000 description 83
- 241000124008 Mammalia Species 0.000 description 63
- 150000007523 nucleic acids Chemical class 0.000 description 55
- 102000039446 nucleic acids Human genes 0.000 description 55
- 108020004707 nucleic acids Proteins 0.000 description 55
- 108090000742 Neurotrophin 3 Proteins 0.000 description 17
- 102000004230 Neurotrophin 3 Human genes 0.000 description 15
- 208000014674 injury Diseases 0.000 description 15
- 229940032018 neurotrophin 3 Drugs 0.000 description 15
- 230000008733 trauma Effects 0.000 description 15
- 210000000653 nervous system Anatomy 0.000 description 12
- 210000004556 brain Anatomy 0.000 description 11
- 230000004770 neurodegeneration Effects 0.000 description 11
- 208000033808 peripheral neuropathy Diseases 0.000 description 11
- 210000001328 optic nerve Anatomy 0.000 description 10
- 208000028867 ischemia Diseases 0.000 description 9
- 210000000278 spinal cord Anatomy 0.000 description 9
- 230000016273 neuron death Effects 0.000 description 8
- 208000006011 Stroke Diseases 0.000 description 7
- 230000007547 defect Effects 0.000 description 7
- 208000010125 myocardial infarction Diseases 0.000 description 7
- 208000032253 retinal ischemia Diseases 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 208000010412 Glaucoma Diseases 0.000 description 6
- 208000010496 Heart Arrest Diseases 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 6
- 230000030833 cell death Effects 0.000 description 6
- 230000007850 degeneration Effects 0.000 description 6
- 210000002569 neuron Anatomy 0.000 description 6
- 230000002980 postoperative effect Effects 0.000 description 6
- 230000002207 retinal effect Effects 0.000 description 6
- 108010025020 Nerve Growth Factor Proteins 0.000 description 5
- 102000007072 Nerve Growth Factors Human genes 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 208000024827 Alzheimer disease Diseases 0.000 description 4
- 201000010374 Down Syndrome Diseases 0.000 description 4
- 208000023105 Huntington disease Diseases 0.000 description 4
- 208000006264 Korsakoff syndrome Diseases 0.000 description 4
- 208000028389 Nerve injury Diseases 0.000 description 4
- 208000018737 Parkinson disease Diseases 0.000 description 4
- 206010044688 Trisomy 21 Diseases 0.000 description 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 206010015037 epilepsy Diseases 0.000 description 4
- 230000008764 nerve damage Effects 0.000 description 4
- 208000015122 neurodegenerative disease Diseases 0.000 description 4
- 230000007823 neuropathy Effects 0.000 description 4
- 201000001119 neuropathy Diseases 0.000 description 4
- 201000006474 Brain Ischemia Diseases 0.000 description 3
- 208000013016 Hypoglycemia Diseases 0.000 description 3
- 206010021143 Hypoxia Diseases 0.000 description 3
- 230000002218 hypoglycaemic effect Effects 0.000 description 3
- 230000007954 hypoxia Effects 0.000 description 3
- 102100029268 Neurotrophin-3 Human genes 0.000 description 2
- 208000030768 Optic nerve injury Diseases 0.000 description 2
- 208000036982 Spinal cord ischaemia Diseases 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000007971 neurological deficit Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9179198P | 1998-07-06 | 1998-07-06 | |
| US60/091,791 | 1998-07-06 | ||
| PCT/US1999/015106 WO2000001440A2 (en) | 1998-07-06 | 1999-07-02 | Methods for treating neurological injuries and disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002519394A JP2002519394A (ja) | 2002-07-02 |
| JP2002519394A5 true JP2002519394A5 (https=) | 2006-08-17 |
Family
ID=22229675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000557884A Pending JP2002519394A (ja) | 1998-07-06 | 1999-07-02 | 神経損傷および障害を治療するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1094863A4 (https=) |
| JP (1) | JP2002519394A (https=) |
| KR (1) | KR20010079503A (https=) |
| AU (1) | AU771437B2 (https=) |
| CA (1) | CA2336718A1 (https=) |
| WO (1) | WO2000001440A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1439191T3 (da) * | 2004-01-19 | 2006-08-14 | Ares Trading Sa | Proces til oprensning af bakterielt udtrykte proteiner |
| JPWO2008133141A1 (ja) * | 2007-04-24 | 2010-07-22 | 東洋紡績株式会社 | オスモチン組換えタンパク質およびその製造方法、並びにその利用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2085134C (en) * | 1990-06-15 | 2003-03-18 | Carnegie Institution Of Washington | Gdf-1 |
| US5652118A (en) * | 1991-03-11 | 1997-07-29 | Creative Biomolecules, Inc. | Nucleic acid encoding a novel morphogenic protein, OP-3 |
| US5635372A (en) * | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
| US5767252A (en) * | 1996-04-08 | 1998-06-16 | The Johns Hopkins University School Of Medicine | Neuronal cell growth factor, Narp |
-
1999
- 1999-07-02 EP EP99939649A patent/EP1094863A4/en not_active Withdrawn
- 1999-07-02 JP JP2000557884A patent/JP2002519394A/ja active Pending
- 1999-07-02 WO PCT/US1999/015106 patent/WO2000001440A2/en not_active Ceased
- 1999-07-02 AU AU53902/99A patent/AU771437B2/en not_active Ceased
- 1999-07-02 KR KR1020017000235A patent/KR20010079503A/ko not_active Withdrawn
- 1999-07-02 CA CA002336718A patent/CA2336718A1/en not_active Abandoned
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