JP2002345492A - New gene and protein encoded by the gene - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a DNA, a gene including the DNA, a recombinant polypeptide encoded by the DNA and a new recombinant protein including the polypeptide by directly cloning a new DNA including a region encoding the protein from a cDNA library derived from a human adult whole brain, a human adult hippocampus and a human fetal whole brain, determining the base sequence of the new DNA, and furthermore identifying the function thereof. SOLUTION: Disclosed are a DNA comprising a base sequence encoding a polypeptide represented by the following (a) or (b): (a) a polypeptide comprising a same or practically same amino acid sequence as an amino acid sequence represented by either one of specific 234 kinds of amino acid sequences; (b) a polypeptide comprising an amino acid sequence in which some amino acids are deleted, substituted or added from/for/to the amino acid sequence represented by either one of the specific 234 kinds of the amino acid sequence and having a practically equal biological activity to the function of the polypeptide of (a), a recombinant polypeptide encoded by the DNA and a protein including the polypeptide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to DNA and the DN
The present invention relates to a gene containing A, a recombinant polypeptide encoded by the DNA, and a novel recombinant protein containing the polypeptide.

[0002]

2. Description of the Related Art Information on the nucleotide sequence of the human genome is being produced daily by large-scale sequencing in the Human Genome Project. The ultimate goal of the Human Genome Project is not simply to determine the entire nucleotide sequence of the genome, but to interpret various human phenomena from its structural information, that is, the nucleotide sequence information of DNA. The region encoding a protein in the human genome sequence is a very small part of the region. At present, the coding region is predicted using a neutral network or an information science technique called a hidden Markov model. However, their prediction accuracy is not yet sufficient.

[0003] In order to find novel genes, the present inventors have directly synthesized novel DNA containing a protein-encoding region from a cDNA library derived from human adult whole brain, human adult hippocampus and human fetal whole brain. The cloning was successful and their nucleotide sequences were determined to complete the present invention.

[0004]

That is, as a first aspect, the present invention relates to a DNA comprising a base sequence encoding the following polypeptide (a) or (b): (a) SEQ ID NO: 1 Or a polypeptide consisting of an amino acid sequence identical or substantially identical to the amino acid sequence represented by any one of (b) SEQ ID NOs: 1 to 234
In the amino acid sequence represented by any one of the above, the amino acid sequence comprises an amino acid sequence in which some amino acids are deleted, substituted or added, and has a biological activity substantially equivalent to the function of the polypeptide of (a). Polypeptide. As a second aspect of the present invention, the present invention relates to the following DNA (a) or (b): (a) In the nucleotide sequence represented by any one of SEQ ID NOs: 1 to 234, DNA encoding the amino acid sequence, (b) hybridizes with the DNA of (a) under stringent conditions, and encodes a protein having substantially the same biological activity as the function of the polypeptide of (a). DNA. The DNAs according to the first and second aspects of the present invention described above are collectively referred to as "DN of the present invention."
A ". The present invention also relates to genes containing these DNAs. Further, the present invention relates to a recombinant polypeptide encoded by the DNA (hereinafter, also referred to as “the polypeptide of the present invention”) and a recombinant protein containing the polypeptide.

[0005] The names of the clones having the DNA of the present invention, the length of the polypeptide or protein of the present invention, and the functions thereof are shown in Tables 1 to 11.

The DNA of the present invention is prepared by using the commercially available mRNA of human adult whole brain, human adult hippocampus and human fetal whole brain (Clontech) as a starting material.
After isolation as a cDNA fragment from a DNA library, the nucleotide sequence was determined and identified. That is, specifically, the method of Ohara et al. (DNA Research Vol. 4, 53-59)
(1997)). Clones are randomly isolated from cDNA libraries derived from human adult whole brain, human adult hippocampus and human fetal whole brain prepared according to (1997)). Next, the duplicated clones (clones that repeatedly appear) were removed by hybridization, followed by in vitro transcription and translation.
The nucleotide sequence of both ends of a clone in which a product of kDa or more is recognized is determined. Further, a homology search is performed in a database of known genes using the thus obtained terminal nucleotide sequence as a query, and as a result, the entire nucleotide sequence is determined for a clone that has been found to be novel. In this manner, an unknown gene that cannot be obtained by a conventional cloning method depending on a known gene can be systematically cloned. The entire region of the human-derived gene including the DNA of the present invention can also be obtained by using a PCR method such as RACE while paying sufficient attention so that artificial errors do not occur in the short fragment or the obtained sequence. It is also possible to prepare.

Further, the present invention provides a recombinant vector containing the DNA of the present invention or a gene containing the DNA of the present invention, a transformant carrying the recombinant vector, and culturing the transformant to obtain the polypeptide or the polypeptide of the present invention. A method for producing a polypeptide of the present invention, a recombinant protein containing the polypeptide, or a salt thereof, which comprises producing, accumulating, and collecting a recombinant protein containing the polypeptide, and a method for producing the same. The present invention provides a polypeptide of the present invention, a recombinant protein containing the polypeptide, or a salt thereof.

[0008] The present invention also relates to a medicament containing the DNA of the present invention, a polypeptide of the present invention or a partial peptide thereof, or a D-protein encoding a recombinant protein containing the polypeptide.
The present invention relates to an antisense nucleotide having a nucleotide sequence substantially complementary to NA or a drug containing the same, and a drug containing the polypeptide of the present invention or a partial peptide thereof or a recombinant protein containing the polypeptide. .
Furthermore, the present invention provides an antibody against the polypeptide of the present invention or a partial peptide thereof, or a recombinant protein containing the polypeptide or a salt thereof, and a polypeptide of the present invention.
A screening method, a screening kit, and a screening method for a substance that specifically interacts with the partial peptide, a recombinant protein containing the polypeptide, a salt thereof, or an antibody thereto, which comprises using the antibody thereto. It also relates to the substance (compound) itself identified by the method.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The DNA of the present invention may be any DNA as long as it comprises a base sequence encoding the polypeptide of the present invention described above. Also, human brain, or other tissues, such as heart, lung, liver,
CDNA derived from cells / tissues such as spleen, kidney, testis, etc.
CDNA identified and isolated from a library or the like, or
Any of synthetic DNAs may be used. The vector used for the library construction may be any of bacteriophage, plasmid, cosmid, phagemid and the like. In addition, the total RNA fraction or m
Using the prepared RNA fraction, direct ReverseTrans
cription Polymerase Chain Reaction (hereinafter “RT-
PCR method).

An amino acid sequence substantially identical to the amino acid sequence represented by any one of SEQ ID NOs: 1 to 234 is a homologous sequence to the entire amino acid sequence represented by any one of SEQ ID NOs: 1 to 234. Sex degree is about 7 on average
It means an amino acid sequence that is 0% or more, preferably about 80% or more, more preferably about 90% or more, and particularly preferably about 95% or more. Accordingly, the polypeptide of the present invention consisting of an amino acid sequence substantially identical to the amino acid sequence represented by any one of SEQ ID NOs: 1 to 234 includes:
For example, a biological activity (function) having the above-mentioned homology to the amino acid sequence represented by each SEQ ID NO, and substantially the same function as the function of the polypeptide comprising the amino acid sequence represented by each SEQ ID NO: Can be mentioned. Here, “substantially the same quality” means that their activities (functions) are the same in nature. In addition, the polypeptide of the present invention includes, for example, a part (preferably about 1 to 20, more preferably about 1 to 10) in the amino acid sequence represented by any one of SEQ ID NOS: 1 to 234, (Preferably several amino acids) consisting of an amino acid sequence in which amino acids are deleted, substituted or added, or an amino acid sequence obtained by combining them, and a polypeptide comprising the amino acid sequence represented by any one of SEQ ID NOs: 1 to 234. Also included are polypeptides having a biological activity (function) substantially the same as the function.

A polypeptide consisting of an amino acid sequence substantially identical to the amino acid sequence represented by any one of the above SEQ ID NOs: 1 to 234, or an amino acid sequence in which some amino acids have been deleted, substituted or added Can be easily prepared by appropriately combining well-known methods such as site-directed mutagenesis, homologous recombination, primer extension, and PCR. . At this time, in order to have substantially the same biological activity, among the amino acids constituting the polypeptide, homologous amino acids (polar / non-polar amino acids, hydrophobic / hydrophilic amino acids, positive / negative amino acids) Substitution between charged amino acids, aromatic amino acids, etc.) is considered as a possibility. In order to maintain substantially the same biological activity, it is desirable that amino acids in the functional domain contained in each polypeptide of the present invention be retained.

Further, the DNA of the present invention is a DNA encoding the amino acid sequence represented by any one of the nucleotide sequences represented by any one of SEQ ID NOs: 1 to 234,
And a DNA encoding a polypeptide (protein) that hybridizes with the DNA under stringent conditions and has a biological activity (function) equivalent to the function of the polypeptide consisting of the amino acid sequence represented by each sequence. Include. Under such conditions, in the base sequence represented by any one of SEQ ID NOs: 1 to 234, the DNA capable of hybridizing with the DNA encoding the amino acid sequence represented by each sequence includes, for example, all bases of the DNA. Examples include DNAs containing a base sequence having a degree of homology with the sequence of about 80% or more, preferably about 90% or more, more preferably about 95% or more on the average.
Hybridization is performed using Current Protocols in Molecular Biology (Current protocol
ols in molecular biology (edited by Frederick M. A
usubel et al., 1987)) and the like, or any method known in the art or a method analogous thereto. When using a commercially available library,
It can be performed according to the method described in the attached instruction manual. Here, “stringent conditions” refers to, for example, 1 mM sodium EDTA at 65 ° C., 0.5 M sodium hydrogen phosphate (pH 7.2), hybridized in a 7% SDS aqueous solution, and 1 mM sodium EDTA at 65 ° C. The condition is such that the probe hybridizes to the DNA probe of the present invention by Southern blot hybridization under conditions in which the membrane is washed in an aqueous solution of 40 mM sodium hydrogen phosphate (pH 7.2) and 1% SDS.

As a means for cloning the DNA of the present invention, the DNA is amplified by the PCR method using a synthetic DNA primer having an appropriate nucleotide sequence such as a portion of the polypeptide of the present invention, or the DNA incorporated into an appropriate vector is used as the cloning DNA. Selection can be made by hybridization with a DNA fragment encoding a part or all of the polypeptide of the invention or labeled with a synthetic DNA. The hybridization method is, for example, as described above.
Current protocols in molecular biology (edited by
Frederick M. Ausubel et al., 1987). When a commercially available library is used, it can be performed according to the method described in the attached instruction manual. The DNA encoding the cloned polypeptide can be used as it is depending on the purpose, or can be used after digesting with a restriction enzyme or adding a linker, if desired. The DNA may have ATG as a translation initiation codon at the 5 'end and TAA, TGA or TAG as a translation stop codon at the 3' end. These translation initiation codon and translation termination codon can also be added using a suitable synthetic DNA adapter.

The expression vector of the protein of the present invention can be prepared according to a method known in the art. For example, it can be produced by cutting out (1) a DNA fragment containing the DNA of the present invention or a gene containing the DNA of the present invention, and (2) ligating the DNA fragment downstream of a promoter in an appropriate expression vector. As the vector, a plasmid derived from Escherichia coli (eg, pBR322, pB
R325, pUC18, pUC118) and plasmids derived from Bacillus subtilis (eg, pUB110, pTP5, pC19)
4), yeast-derived plasmids (eg, pSH19, pSH1
5), bacteriophages such as λ phage, and animal viruses such as retrovirus, vaccinia virus, and baculovirus can be used. The promoter used in the present invention may be any promoter as long as it is appropriate for the host used for gene expression. For example, if the host is E. coli, trp
Promoter, lac promoter, recA promoter, λPL promoter, lpp promoter, etc., when the host is Bacillus subtilis, SPO1 promoter, SPO2 promoter, penP promoter, etc., when the host is yeast, PHO5 promoter
PGK promoter, GAP promoter, ADH promoter and the like are preferable. When animal cells are used as a host, SRα promoter, SV40 promoter,
LTR promoter, CMV promoter, HSV-T
K promoter and the like.

[0015] In addition to the above, the expression vector may further include an enhancer, a splicing signal, a polyA addition signal, a selection marker, SV
Forty replication origins and the like can be added. Further, if necessary, the protein encoded by the DNA of the present invention can be expressed as a fusion protein with another protein (eg, glutathione S-transferase and protein A). Such a fusion protein can be cleaved using a protease of the applicable name and separated into respective proteins.

As the host cell, for example, Escherichia, Bacillus, yeast, insect cells, insects, animal cells and the like are used. Specific examples of Escherichia bacteria include Escherichia coli K12.
DH1 (Proc. Natl. Acad. Sci. USA, 60, 1
60 (1968)), JM103 (Nucleic Acids Resear)
ch, 9, 309 (1981)), JA221 (Journal
of Molecular Biology, 120, 517 (197
8)), and HB101 (Journal of Molecular Biolog
y, Vol. 41, 459 (1969)). Examples of Bacillus bacteria include, for example, Bacillus subtilis (Baci
llus subtilis) MI114 (Gene, 24, 255 (1
983)), 207-21 [Journal of Biochemistry,
95, 87 (1984)]. Examples of yeast include Saccharomyces cerevisiae (Saccaromy)
ces cerevisiae) AH22, AH22R-, NA87-
11A, DKD-5D, 20B-12, Schizosaccaromyces pombe NCYC
1913, NCYC2036, Saccharomyces pichia pastoris and the like. As animal cells, for example, monkey cells COS
-7, Vero, Chinese hamster cells CHO (hereinafter abbreviated as CHO cells), dhfr gene-deficient CHO cells, mouse L cells, mouse AtT-20, mouse myeloma cells, rat GH3, human FL cells, and the like.

Transformation of these host cells can be performed according to methods known in the art. For example, the following documents can be referred to. Proc. Natl.
Acad. Sci. USA, 69, 2110 (1972); Ge
ne, 17, 107 (1982); Molecular & General
Genetics, 168, 111 (1979); Methods in
Enzymology, 194, 182-187 (1991);
Proc. Natl. Acad. Sci. USA), 75, 1929.
(1978); Cell Engineering Separate Volume 8, New Cell Engineering Experiment Protocol. 263-267 (1995) (published by Shujunsha); and Virology, 52, 456 (1973).

The thus obtained transformant transformed with the expression vector containing the DNA of the present invention or a gene containing the DNA of the present invention can be cultured according to a method known in the art. For example, the following documents can be referred to. For example, when the host is a bacterium belonging to the genus Escherichia, culturing is usually performed at about 15 to 43 ° C. for about 3 to 3 hours.
It is performed for 24 hours, and if necessary, ventilation and stirring can be added. When the host is a bacterium belonging to the genus Bacillus, the cultivation is usually carried out at about 30 to 40 ° C. for about 6 to 24 hours, and if necessary, aeration and stirring can be applied. When culturing a transformant in which the host is yeast, culturing is usually performed at about 20 ° C. to 35 ° C. for about 24 to 72 hours using a medium adjusted to a pH of about 5 to 8, if necessary, by aeration or the like. Stirring can also be added. When culturing a transformant whose animal host is an animal cell, p
H is usually about 30 ° C. using a medium adjusted to about 6 to 8.
The reaction is carried out at ４０40 ° C. for about 15 to 60 hours, and aeration and stirring can be added as necessary.

In order to separate and purify the polypeptide or protein of the present invention from the above-mentioned culture, for example, after culturing, cells or cells are collected by a known method, suspended in an appropriate buffer, sonicated, lysozyme After disrupting the cells or cells by freeze-thawing or the like, a crude extract of the protein is obtained by centrifugation or filtration. In a buffer solution, a protein denaturant such as urea or guanidine hydrochloride, or Triton X-1
00 ^TM surfactant may be included, such as. When the protein is secreted into the culture solution, after the culture is completed, the supernatant is separated from the cells or cells by a known method, and the supernatant is collected. The protein contained in the thus obtained culture supernatant or extract can be purified by appropriately combining known separation and purification methods. The thus obtained polypeptide (protein) of the present invention can be converted to a salt by a known method or a method analogous thereto,
Conversely, when it is obtained as a salt, it can be converted into a free form or another salt by a known method or a method analogous thereto. Furthermore, before or after purification of the protein produced by the recombinant, an appropriate protein modification enzyme such as trypsin and chymotrypsin is allowed to act on the protein to optionally modify it or partially remove the polypeptide. Can also. The presence of the polypeptide (protein) of the present invention or a salt thereof can be measured by various binding assays, enzyme immunoassays using specific antibodies, and the like.

The polypeptide (protein) of the present invention has a C-terminal
Is usually a carboxyl group (-COOH) or
Rate (-COO-), but the C-terminal is an amide (-COO-).
NH _Two) Or an ester (—COOR)
No. Here, as R in the ester, for example, methyl
, Ethyl, n-propyl, isopropyl or n-
C1-6 alkyl group such as butyl, for example, cyclopentene
C3-8 cycloalkyl groups such as cyclohexyl and cyclohexyl, examples
For example, C6-12 aryl such as phenyl and α-naphthyl
Groups, for example phenyl-C such as benzyl, phenethyl, etc.
1-2 alkyl group or α- such as α-naphthylmethyl
C7-14 aralkyl groups such as naphthyl-C1-2 alkyl groups
In addition, pivaloylo, commonly used as an oral ester
Xymethyl esters and the like are used.

When the polypeptide (protein) of the present invention has a carboxyl group (or carboxylate) at a position other than the C-terminus, a protein in which the carboxyl group is amidated or esterified is also included in the protein of the present invention. As the ester in this case, for example, the above-mentioned C-terminal ester and the like are used. Further, the protein of the present invention includes N
When the amino group of the terminal methionine residue is protected by a protecting group (for example, a C1-6 acyl group such as a formyl group or an acetyl group), the N-terminal glutamic acid residue formed by cleavage in vivo is Pyroglutamate, on the side chain of an amino acid in the molecule, such as OH, COOH,
Includes those in which NH ₂ , SH, etc. are protected with an appropriate protecting group (eg, C 1-6 acyl group such as formyl group, acetyl group, etc.), and complex proteins such as so-called glycoproteins having sugar chains bonded thereto. It is.

The partial peptide of the protein of the present invention includes
Any partial peptide of the polypeptide (protein) of the present invention described above may be used as long as it has substantially the same activity. For example, at least 10 or more, preferably 50 or more, more preferably 70 or more, more preferably 100 or more, and most preferably 20 or more of the constituent amino acid sequences of the polypeptide (protein) of the present invention.
For example, a peptide having 0 or more amino acid sequences and having a biological activity substantially the same as the function of the polypeptide of the present invention is used. The partial peptide of the present invention usually has a carboxyl group (—COOH) or a carboxylate (—COO—) at the C-terminus, but has an amide (—CONH) at the C-terminus as in the protein of the present invention described above.
₂ ) or an ester (—COOR). Further, similar to the above-mentioned protein of the present invention, the partial peptide of the present invention includes a peptide in which the amino group of the N-terminal methionine residue is protected with a protecting group, and a glutamyl formed by cleavage of the N-terminal side in vivo. Wherein the group is oxidized by pyroglutamine,
Also included are those in which the substituent on the side chain of the amino acid in the molecule is protected with an appropriate protecting group, and those in which a sugar chain is bound, such as a complex peptide such as a so-called glycopeptide. The partial peptide of the present invention includes, for example, reagents, standard substances used in experiments,
Alternatively, it can be used as an immunogen or a part thereof.

The salt of the polypeptide (protein) of the present invention or a partial peptide thereof is preferably a physiologically acceptable acid addition salt. Such salts include, for example,
Salts with inorganic acids (eg, hydrochloric acid, phosphoric acid, hydrobromic acid, sulfuric acid) or organic acids (eg, acetic acid, formic acid, propionic acid, fumaric acid, maleic acid, succinic acid, tartaric acid, citric acid, malic acid) , Oxalic acid, benzoic acid, methanesulfonic acid,
For example, a salt with benzenesulfonic acid) is used.

The polypeptide (protein) of the present invention, its partial peptide, a salt thereof, or an amide thereof can also be prepared by a chemical synthesis method known in the art. For example, using a commercially available resin for protein synthesis, an amino acid appropriately protected with an α-amino group and a side chain functional group may be subjected to various condensation methods known per se in the art according to the sequence of the target protein. , On a resin. At the end of the reaction, the protein is cleaved from the resin, and at the same time, various protecting groups are removed.In addition, an intramolecular disulfide bond formation reaction is carried out in a highly diluted solution to obtain the desired protein,
Obtain the partial peptides or their amides.
For the condensation of the protected amino acids described above, for example, DC
C, N, N'-diisopropylcarbodiimide, and N-ethyl
Various activating reagents such as -N '-(3-dimethylaminoprolyl) carbodiimide that can be used for protein synthesis represented by carbodiimides can be used. Activation by these includes racemization inhibiting additives (eg, HOBt, HOOB
The protected amino acid may be directly added to the resin together with t), or may be added to the resin after activating the protected amino acid in advance as a symmetric acid anhydride or HOBt ester or HOOBt ester.

Solvents used for activation of protected amino acids and condensation with resins include acid amides, halogenated hydrocarbons, alcohols, sulfoxides, and ethers, which are used in the art for protein condensation reactions. It can be appropriately selected from known solvents. The reaction temperature is appropriately selected from the range that can be used for the protein bond formation reaction. The activated amino acid derivative is usually used in a 1.5 to 4-fold excess. As a result of the test using the ninhydrin reaction, if the condensation is insufficient, sufficient condensation can be performed by repeating the condensation reaction without removing the protecting group. When sufficient condensation cannot be obtained even by repeating the reaction, the unreacted amino acid can be acetylated using acetic anhydride or acetylimidazole so as not to affect the subsequent reaction. As a protecting group such as each amino group, carboxyl group and serine hydroxyl group of the raw material, a group usually used in the technical field can be used. The protection of the functional group which should not be involved in the reaction of the raw materials, the protecting group, the elimination of the protective group, the activation of the functional group involved in the reaction, and the like can be appropriately selected from known groups or known means.

The partial peptide of the present invention or a salt thereof can be produced according to a peptide synthesis method known per se in the art, or by cleaving the protein of the present invention with an appropriate peptidase. As a method for synthesizing a peptide, for example, any of a solid phase synthesis method and a liquid phase synthesis method may be used. Examples of the known condensation method and elimination of the protecting group include the methods described in the following (1) to (3). (1) Nobuo Izumiya et al., Basics and experiments on peptide synthesis, Maruzen
Co., Ltd. (1975) (2) Haruaki Yajima and Shunpei Sakakibara, Laboratory of Biochemistry 1,
Protein Chemistry IV, 205, (1977) (3) Supervised by Haruaki Yajima, Development of Continuing Drugs Volume 14 Peptide Synthesis Hirokawa Shoten Purification after the reaction is also a method known per se, for example, solvent extraction, distillation, and column chromatography. -The partial peptide of the present invention can be purified and isolated by a combination of liquid chromatography and recrystallization. When the partial peptide obtained by the above method is in a free form, it can be converted to an appropriate salt by a known method. Can be.

Antibodies against the polypeptide (protein) of the present invention, its partial peptide, or a salt thereof may be any of a polyclonal antibody and a monoclonal antibody as long as they can recognize them. Antibodies against the polypeptide (protein) of the present invention, its partial peptide or a salt thereof can be produced by using the polypeptide (protein) of the present invention or its partial peptide as an antigen according to a known method for producing an antibody or antiserum. . The antibody of the present invention can be used for detecting the polypeptide (protein) of the present invention or the like present in a subject such as a body fluid or a tissue. In addition, preparation of an antibody column used for purifying them, detection of the polypeptide of the present invention (protein) in each fraction during purification, analysis of the behavior of the polypeptide of the present invention (protein) in test cells, etc. Can be used for

Furthermore, the antibody of the present invention can be determined by known methods such as quantification of the polypeptide (protein) of the present invention in a test solution, in particular, quantification by a sandwich immunoassay using a monoclonal antibody, and tissue staining. It can be used for detection and the like. Thereby, for example, a disease associated with the polypeptide (protein) of the present invention or the like can be diagnosed. For these purposes, the antibody molecule itself may be used, and F (ab ') 2, Fab',
Alternatively, the Fab fraction may be used. The method for quantifying the protein or the like of the present invention using the antibody of the present invention is not particularly limited, and may be an antibody, an antigen, or an antibody-antigen complex corresponding to the amount of antigen (eg, the amount of protein) in the test solution. Any method may be used as long as it is a method for detecting the amount of by chemical or physical means and calculating the amount from a standard curve prepared using a standard solution containing a known amount of antigen. For example, nephelometry, a competitive method, an immunometric method, and a sandwich method are suitably used, but it is preferable to use a sandwich method described later in terms of sensitivity and specificity. As a labeling agent used in a measurement method using a labeling substance, for example, a radioisotope, an enzyme, a fluorescent substance, a luminescent substance, and the like known in the art can be used.

For details of general technical means relating to these measurement / detection methods, a review, a textbook, and the like can be referred to. For example, edited by Hiro Irie, “Radio Immunoassay” (Kodansha, published in 1979), Eiji Ishikawa et al., “Enzyme Immunoassay” (3rd edition) (Medical Publishing, published in 1987), “Methods in ENZYMOLOGY” Vol. .70 (Immunoche
mical Techniques (Part A)), ibid.Vol. 73 (Immunoche
mical Techniques (Part B)), Ibid.Vol. 74 (Immunochem
ical Techniques (Part C)), ibid.Vol. 84 (Immunochem
ical Techniques (Part D: Selected Immunoassays)),
Ibid.Vol. 92 (Immunochemical Techniques (Part E: Mono
clonal Antibodies and General Immunoassay Method
s)), ibid.Vol. 121 (Immunochemical Techniques (Part
I: HybridomaTechnology and Monoclonal Antibodies))
(Above, published by Academic Press).

The antisense DNA having a nucleotide sequence substantially complementary to the DNA encoding the polypeptide (protein) of the present invention or a partial peptide thereof includes the DNA
Has a base sequence substantially complementary to the base sequence of
Any antisense DNA may be used as long as it has an effect of suppressing the expression of A. The substantially complementary base sequence is, for example, preferably about 90 or more, more preferably about 95% or more, and most preferably 100% or more of the entire base sequence or a partial base sequence of the base sequence complementary to the DNA of the present invention. And the like. Nucleic acid sequences (modified RNA or DNA) having the same action as these antisense DNAs are also included in the antisense DNA referred to in the present invention. These antisense DNAs can be produced using a known DNA synthesizer or the like.

Furthermore, the polypeptide (protein) of the present invention is useful as a reagent for screening compounds that specifically interact with these substances. That is, the present invention uses a polypeptide (protein) of the present invention, a partial peptide thereof or a salt thereof, or an antibody against the same, and screens for a compound that specifically interacts with the substance or a salt thereof. Methods and screening kits therefor are provided. The compound identified by using the screening method or the screening kit of the present invention or a salt thereof is a compound selected from the test compounds described above, interacts with the polypeptide (protein) of the present invention and the like, Modulate, inhibit,
It is a compound that promotes or antagonizes. The compound or a salt thereof may directly act on the activity of the protein or the like of the present invention, or may indirectly act on the expression of the polypeptide (protein) of the present invention or the like to inactivate the polypeptide or the protein of the present invention (protein). ) And the like. As the salt of the compound, for example, a pharmaceutically acceptable salt or the like is used. Examples include salts with inorganic bases, salts with organic bases, salts with inorganic acids, salts with organic acids, salts with basic or acidic amino acids, and the like. Compounds that inhibit biological activities such as the polypeptides (proteins) of the present invention may also be used as medicaments such as therapeutic / prophylactic agents for the above various diseases.

By using the DNA of the present invention and a gene containing the DNA as a probe, DNA or mR encoding the polypeptide of the present invention or a partial peptide thereof can be obtained.
Since an abnormality of NA (gene abnormality) can be detected, it is useful as a gene diagnostic agent for, for example, damage, mutation or decreased expression of the DNA or mRNA, and increased or excessive expression of the DNA or mRNA.
The genetic diagnosis using the DNA of the present invention includes, for example,
Known Northern hybridization and PCR-SS
CP method (Genomics, Vol. 5, pp. 874-879 (198
9 years), Proceedings of the National Academy of Sci
ences of the United States of America, Vol. 86,
2766-2770 (1989)). Further, when the DNA or gene of the present invention is abnormal or defective, or when the expression level is reduced, patients who cannot exhibit normal functions in vivo can be treated according to the known means (1) The DNA or gene of the present invention is introduced and expressed in the patient by gene therapy using a suitable vector such as a viral vector, an adenovirus vector, an adenovirus associated virus vector as a vehicle, or (2) the present invention. By injecting the protein or the like into the patient, it is considered that the function of the protein or the like of the present invention can be exhibited in the patient. The DNA or gene of the present invention can be administered by a gene gun or a catheter such as a hydrogel catheter, using the DNA alone or together with an auxiliary agent for promoting uptake.

In the present specification and drawings, when bases, amino acids and the like are represented by abbreviations, IUPAC-IUB C
abbreviation by ommision on Biochemical Nomenclature or common abbreviation in the field,
When an amino acid can have an optical isomer, the L-form is indicated unless otherwise specified.

[0034]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, but it should not be construed that the invention is limited thereto. Note that various genetic manipulations in the Examples
rrent protocols in molecular biology (edited by Fr
ederick M. Ausubel et al., 1987).

(1) Construction of cDNA library derived from human adult whole brain, human adult hippocampus and human fetal whole brain Oligonucleotide having NotI site (GACTA
GTTCTAGATCGCGAGCGGCGCCCCC
(T) ₁₅ ) (Gibco BRL) as a primer
MR from human adult whole brain, human adult hippocampus and human fetal whole brain
Double-stranded cDNA was synthesized using a SuperScript II reverse transcriptase kit (Gibco BRL) using NA (Clontech) as a template. Adapter with SalI site (Gibco BR
L) was ligated with cDNA. Then, No
After digestion with tI, a DNA fragment of 3 kb or more was purified by 1% concentration low melting agarose electrophoresis. Purified cDNA
The fragment was treated with SalI-NotI restriction enzyme pBluescr
Ligation with ipt IISK + plasmid. E. coli
This recombinant plasmid was introduced into ElectroMax DH10B strain (Gibco BRL) by electroporation.

(2) Screening Next, clones were randomly picked from the thus constructed cDNA library and spotted on a membrane. Next, oligo DNAs (21 bases each) prepared based on the nucleotide sequences of about 1,300 clones whose full length has already been analyzed by the present inventors.
Each of the 3 ′ ends of the mixture was labeled with DIG with terminal transferase, and these were used as probes to perform dot hybridization (Current protocols in m.
olecular biology (edited by Frederick M. Ausubel e
t al., 1987)), duplicate clones (repeated clones) were removed. Next, in vitro transcription and translation (Promega TNT T7 Quick Coupled Transcription / T
ranslation System cat.no.L1107), 50kDa
A clone showing the above products was selected. Next, the terminal base sequence of the selected clone was determined, and the obtained sequence was used as a query for the homology search program BLASTN 2.0.14 (A
ltschul, Stephen F., Thomas L. Madden, Alejandro
A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Mill
er, andDavid J. Lipman (1997), "Gapped BLAST and P
SI-BLAST: a new generation of protein database sea
rch programs ", Nucleic Acids Res. 25: 3389-3402), using nr (All GenBank + EMBL + DDBJ + PDB sequences (bu
t no EST, STS, GSS, orphase 0,1 or 2 HTGS sequence
s)) A homology search was performed on the database. As a result, the entire nucleotide sequence was determined for the case where no homologous gene was present, that is, for the case of a novel gene. For sequencing, a DNA sequencer (ABI PRISM377) manufactured by PE Applied Biosystems and a reaction kit manufactured by the company were used. Most sequences were determined from shotgun clones using the dye terminator method. For some base sequences, oligonucleotides were synthesized based on the determined base sequence and determined by the primer walking method.

Thus, screening of a novel DNA or gene was performed. As a result, a novel DNA or gene represented by any one of SEQ ID NOs: 1 to 234 in the sequence listing was detected. The nucleotide sequence of these novel DNAs or genes was determined by the above-described sequencing method. The names of the clones having the DNA or gene of the present invention are shown in Tables 1 to 11.

(3) Homology search of the DNA of the present invention Next, based on the total nucleotide sequence thus obtained, the amino acid sequence of the clone was converted into a known sequence library nr release Sep.
Analysis program BLASTP 2.0.14 (Altsc
hul, Stephen F., Thomas L. Madden, Alejandro A. Sc
haffer, Jinghui Zhang, Zheng Zhang, Webb Miller, a
nd David J. Lipman (1997), "Gapped BLAST and PSI-B
LAST: a new generation of protein database search
programs ", Nucleic Acids Res. 25: 3389-3402), which revealed homology with each of the homologous genes shown in Tables 12 to 27. Contains information on these homologous genes, that is, their names, database IDs, species, protein lengths, and description documents.
The meanings of the abbreviations are described in Table 28.

Further, the DNA of the present invention contained in each clone
Alternatively, various data on the homology between the gene and each homologous gene shown in Tables 12 to 27 are summarized in Tables 29 to 35. The meaning of each item in these tables is as follows. The origin of the homologous region of the "clone from" clone The end of the homologous region of the "clone to" clone The origin of the homologous region of the "homologous gene from" homologous gene The end of the homologous region of the "homologous gene to" homologous gene "Score" The higher the value, the higher the reliability “E-value” The closer this value is to 0, the higher the reliability The higher the homology, the percentage of amino acid residue matches in the homologous region The percentage of homology, the homology in the homologous gene Area percentage

(4) Search for various domains Next, the amino acid sequence encoded by the DNA contained in the clone was used as a query, and the search tool Pf included in Pfam 5.2 was used.
am HMM ver 2.1 Search (HMMPFAM) (Sonnhammer ELL, E
ddy SR, Birney E, Bateman A, Durbin R (1998) Pfam:
multiple sequence alignments and HMM-profiles of
protein domains, Nucleic Acids Research 26: 320-32
Functional domains were searched using 2). Furthermore, the SOSUI system (ver. 1.0 / 10, Mar.,
1996) (Takatsugu Hirokawa, Seah Boon-Chieng and S
higeki Mitaku, SOSUI: Classification and Secondary
Structure Prediction System for Membrane Protein
s, Bioinformatics (formerly CABIOS) 1998 May; 14
(4): 378-379.) To search for the transmembrane domain. These detected functional domains and transmembrane domains are shown in Tables 36 to 62 for each clone. The meaning of each item in these tables is as follows. "Function domain" Pfam Domain detected by SOSUI "Clone from" Origin of functional domain "Clone to" End of functional domain "Homologous gene from" Origin of functional domain "Homologous gene to" End of functional domain "Score (Pfam only) ) "The higher this value is, the higher the reliability is." Exp (Pfam only) "The closer this value is to 0, the higher the reliability. Also, the complete notation of each functional domain is shown in Tables 63 and 64.

(5) Expression site Using the RT-PCR ELISA, the DNA or gene of the present invention was expressed in Table 7.
The expression in tissues and brain sites shown in FIG. 2 was examined. Organization,
Table 65 shows the strongest expression in each part of the brain.
To Table 71. (6) Chromosome position The DNA acid sequence of the clone is used as crelie, and the analysis program BLASTN 2.0.14 (Altschul, Steph
en F., Thomas L. Madden, Alejandro A. Schaffer, Ji
nghui Zhang, Zheng Zhang, Webb Miller, and David
J. Lipman (1997), "Gapped BLAST and PSI-BLAST: an
ew generation of protein database search program
s ", Nucleic Acids Res. 25: 3389-3402). The description of the number of the chromosome from which this clone was derived was extracted from the description of the matched clone (Definition), and this was extracted from Table 65 to Table 71. It was shown to.

Based on the above information on homology, homologous genes, various domains, expression sites, chromosome positions, etc., those skilled in the art can list the DNA or gene of the present invention in Tables 1 to 11. It can be predicted that each function is provided. The full length of the genes contained in the following clones was determined for the following reasons. fj04751 (SEQ ID NO: 100): Alignment with the homologous gene is considered to include the entire homologous gene. However, there is no homology near the N-terminal of the protein (amino acid sequence 1 to 53 of SEQ ID NO: 100). fj15353 (SEQ ID NO: 135): Alignment with the homologous gene is considered to include the entire homologous gene. However, near the N-terminus of the protein (amino acid sequence 1 of SEQ ID NO: 135)
To 12) are not homologous. fj17066 (SEQ ID NO: 141): From alignment with the homologous gene, it is considered to include the entire homologous gene. hh14180 (SEQ ID NO: 168): It is considered to contain the entire homologous gene based on the alignment with the homologous gene. hj05518 (SEQ ID NO: 177): Alignment with the homologous gene is considered to include the entire homologous gene. However, there is no homology near the C-terminus of the protein (amino acid sequences 318 to 362 of SEQ ID NO: 177). pj00464 (SEQ ID NO: 217): From alignment with homologous gene, it is considered to include the entire homologous gene. However, there is no homology near the N-terminus of the protein (amino acid sequence 1 to 85 of SEQ ID NO: 217). pj01649 (SEQ ID NO: 226): Alignment with the homologous gene is considered to include the entire homologous gene.

The novel DNA or gene obtained in the present invention is accumulated on a so-called DNA chip or the like, and is collected from, for example, blood or tissue of a normal patient as a control and a patient having a brain-related disease such as mental illness. Hybridization of the prepared probe can be useful for diagnosis, treatment and the like of these diseases. Chromosome D extracted from human blood or tissue using synthetic DNA primers prepared based on the DNA or gene base sequence of the present invention.
By performing PCR using NA and determining the base sequence of the product, a single-base mutation, that is, cSNIPs, which differs depending on individuals in the DNA or gene of the present invention can be found. As a result, the constitution and the like of the individual are predicted, and the development of a medicine suitable for each individual becomes possible. In addition, an ortholog (homolog, counterpart) gene for the DNA or gene of the present invention in a model organism such as a mouse is isolated by cross-hybridization,
For example, by knocking out these genes, a human disease model animal can be prepared, and a gene causing human pathogenesis can be searched and identified. Furthermore, the antibody against the DNA or the gene of the present invention is comprehensively prepared, and a so-called PROTEIN chip is prepared by accumulating the antibodies, and the disease is determined by proteome analysis such as detecting a difference in the protein expression level between a patient and a normal person. Can be used for diagnosis, treatment, etc.

[0044]

[Table 1]

[0045]

[Table 2]

[0046]

[Table 3]

[0047]

[Table 4]

[0048]

[Table 5]

[0049]

[Table 6]

[0050]

[Table 7]

[0051]

[Table 8]

[0052]

[Table 9]

[0053]

[Table 10]

[0054]

[Table 11]

[0055]

[Table 12]

[0056]

[Table 13]

[0057]

[Table 14]

[0058]

[Table 15]

[0059]

[Table 16]

[0060]

[Table 17]

[0061]

[Table 18]

[0062]

[Table 19]

[0063]

[Table 20]

[0064]

[Table 21]

[0065]

[Table 22]

[0066]

[Table 23]

[0067]

[Table 24]

[0068]

[Table 25]

[0069]

[Table 26]

[0070]

[Table 27]

[0071]

[Table 28]

[0072]

[Table 29]

[0073]

[Table 30]

[0074]

[Table 31]

[0075]

[Table 32]

[0076]

[Table 33]

[0077]

[Table 34]

[0078]

[Table 35]

[0079]

[Table 36]

[0080]

[Table 37]

[0081]

[Table 38]

[0082]

[Table 39]

[0083]

[Table 40]

[0084]

[Table 41]

[0085]

[Table 42]

[0086]

[Table 43]

[0087]

[Table 44]

[0088]

[Table 45]

[0089]

[Table 46]

[0090]

[Table 47]

[0091]

[Table 48]

[0092]

[Table 49]

[0093]

[Table 50]

[0094]

[Table 51]

[0095]

[Table 52]

[0096]

[Table 53]

[0097]

[Table 54]

[0098]

[Table 55]

[0099]

[Table 56]

[0100]

[Table 57]

[0101]

[Table 58]

[0102]

[Table 59]

[0103]

[Table 60]

[0104]

[Table 61]

[0105]

[Table 62]

[0106]

[Table 63]

[0107]

[Table 64]

[0108]

[Table 65]

[0109]

[Table 66]

[0110]

[Table 67]

[0111]

[Table 68]

[0112]

[Table 69]

[0113]

[Table 70]

[0114]

[Table 71]

[0115]

[Table 72]

[0116]

[Sequence List] SEQUENCE LISTING <110> Kazusa DNA Research Institute <120> Novel Genes and Proteins Encoded by the Genes <130> AB02007 <160> 234 <210> 1 <211> 6380 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (69) .. (2204) <400> 1 ggaaaaaaaa ggcgtgagac atcaggttgt cattttttat tgtgagattc tgctcctaaa 60 gataataa atg ggg gat tac ggg ttt gga gtg cta gtg caa agc aat act 110 Met Gly Asp Tyr Gly Phe Gly Val Leu Val Gln Ser gatt 1 Gt Ser gna tg ag trt 1 gat Serggn cca gtc aga ttc cat cca cat ctg cag cct 158 Gly Asn Lys Ser Ala Phe Pro Val Arg Phe His Pro His Leu Gln Pro 15 20 25 30 cca cac cat cac caa aat gcc acc ccc agc cct gct gct ttt ata aat 206 Pro His His His Gln Asn Ala Thr Pro Ser Pro Ala Ala Phe Ile Asn 35 40 45 aat aac aca gct gcc aat ggc agc agt gct ggg tca gct tgg ctt ttt 254 Asn Asn Thr Ala Ala Asn Gly Ser Ser Ala Gly Ser Ala Trp Leu Phe 50 55 60 cct gct cca gct acc cat aac att cag gat gag atc ttg ggg tca gaa 302 Pro Ala Pro Ala Thr His Asn Ile Gln Asp Glu Ile Leu Gly Ser Glu 65 70 75 aaa gca aaa agt cag caa cag gaa cag caa gac ccc tta gaa aag cag 350 Lys Ala Lys Ser Gln Gln Gln Glu Gln Gln Asp Pro Leu Glu Lys Gln 80 85 90 cag ctt tcc cca agt cca ggt cag gaa gct gga ata ctg cct gaa aca 398 Gln Leu Ser Pro Ser Pro Gly Gln Glu Ala Gly Ile Leu Pro Glu Thr 95 100 105 110 gag aag gca aaa tca gaa gaa aat caa ggg gac aat tct tcg gaa aat 446 Glu Lys Ala Lys Ser Glu Glu Asn Gln Gly Asp Asn Ser Ser Glu Asn 115 120 125 ggc aat ggg aag gag aaa ata agg atc gaa tct cca gtg ttg aca ggg 494 Gly Asn Gly Lys Glu Lys Ile Arg Ile Glu Ser Pro Val Leu Thr Gly 130 135 140 ttt gat tat caa gaa gcc act ggg cta ggt act tca acc caa ccc ttg 542 Phe Asp Tyr Gln Glu Ala Thr Gly Leu Gly Thr Ser Thr Gln Pro Leu 145 150 155 aca tct agc gca tcg tct ctt act ggt ttc agt aac tgg tca gca gcg 590 Thr Ser Ser Ala Ser Ser Leu Thr Gly Phe Ser Asn Trp Ser Ala Ala 160 165 170 ata gcg cct tcc tcc tct aca ata atc aat gaa gat gca agt ttc ttt 638 Ile Ala Pro Ser Ser Ser Thr Ile Ile Asn Glu Asp Ala Ser Phe Phe 175 180 185 190 cac cag gga ggg gtc cct gct gct tcg gct aat aac ggt gct ctg ttg 686 His Gln Gly Gly Val Pro Ala Ala Ser Ala Asn Asn Gly Ala Leu Leu 195 200 205 ttt caa aat ttc ccc cat cat gtc agc cct ggc ttt gga ggc agPhe Gln Asn Phe Pro His His Val Ser Pro Gly Phe Gly Gly Ser Phe 210 215 220 tct cct cag atc ggg cct ctc tca cag cac cac cca cat cac cct cat 782 Ser Pro Gln Ile Gly Pro Leu Ser Gln His His Pro His His Pro His 225 230 235 ttc cag cat cat cac agc cag cat cag cag caa agg agg tct cct gcc 830 Phe Gln His His His Ser Gln His Gln Gln Gln Arg Arg Ser Pro Ala 240 245 250 agt ccc cat ccc cca ccc ttc aca cat aga aat gct gct ttt aac cag 878 Ser Pro His Pro Pro Pro Phe Thr His Arg Asn Ala Ala Phe Asn Gln 255 260 265 270 ctg cct cat ttg gcg aat aat ctt aac aaa ccc ccc tct ccg tgg agc 926 Leu Pro His Leu Ala Asn Asn Leu Asn Lys Pro Pro Ser Pro Trp Ser 275 280 285 agc tac cag agt ccg tca cca aca ccc tcc tct tcc tgg agc ccg ggc 974 Ser Tyr Gln Ser Pro Ser Pro Thr Pro Ser Ser Ser Trp Ser Pro Gly 290 295 300 ggt ggt gga tat ggt ggc tgg gga ggt tcc caa ggc cga gat cac cgc 1022 Gly Gly Gly Tyr Gly Gly Trp Gly Gly Ser Gln Gly Arg Asp His Arg 305 310 315 aga ggg ctg aat ggt gga ata acg ccc ctg aac tcc cct ttg 1070 Arg Gly Leu Asn Gly Gly Ile Thr Pro Leu Asn Ser Ile Ser Pro Leu 320 325 330 aag aaa aat ttt gca agc aat cat att cag ctc cag aag tat gct cgc 1118 Lys Lys Asn Phe Ala Ser Asn His Ile Gln Leu Gln Lys Tyr Ala Arg 335 340 345 350 ccc agc tct gcc ttt gca cct aaa tcc tgg atg gaa gat agc ttg aac 1166 Pro Ser Ser Ala Phe Ala Pro Lys Ser Trp Met Glu Asp Ser Leu Asn 355 360 365 agg gct gac aac att ttt cct ttt ccg gat cgc ccc agg aca ttc gac 1214 Arg Ala Asp Asn Ile Phe Pro Phe Pro Asp Arg Pro Arg Thr Phe Asp 370 375 380 atg cac tca ctg gag agt tca ctc att gac ata atg aga gat Mga gaa aat 1262 Ser Leu Glu Ser Ser Leu Ile Asp Ile Met Arg Ala Glu Asn 385 390 395 gat acc att aaa gca agg aca tat ggg cga agg aga ggt cag tct tca 1310 Asp Thr Ile Lys Ala Arg Thr Tyr Gly Arg Arg Arg Gly Gln Ser Ser 400 405 410 ctg ttt cca atg gaa gat gga ttc ttg gat gat ggc cgt ggg gat cag 1358 Leu Phe Pro Met Glu Asp Gly Phe Leu Asp Asp Gly Arg Gly Asp Gln 415 420 425 430 cct ctt cat agt ggc ctg ggt tca cct cac tgc ttc agt cac cag aat 1406 Pro Leu His Ser Gly Leu Gly Ser Pro His Cys Phe Ser His Gln Asn 435 440 445 ggg gaa aga gtg gaa cga tat tct cga aag gtg ttt gta ggc gga ttg 1454 Glu Glu Arg Val Arg Tyr Ser Arg Lys Val Phe Val Gly Gly Leu 450 455 460 cct cca gac att gat gaa gat gag atc aca gct agt ttt cgt cgc ttt 1502 Pro Pro Asp Ile Asp Glu Asp Glu Ile Thr Ala Ser Phe Arg Arg Phe 465 470 475 475 ggc cct ctg att gtg gat tgg cct cat aaa gct gag agc aaa tcc tat 1550 Gly Pro Leu Ile Val Asp Trp Pro His Lys Ala Glu Ser Lys Ser Tyr 480 485 490 ttt cct cct aaa ggc tat gca ttc ctg ctg tga g agc tct 1598 Phe Pro Pro Lys Gly Tyr Ala Phe Leu Leu Phe Gln Asp Glu Ser Ser 495 500 505 510 gtg cag gct ctc att gat gca tgc att gaa gaa gat gga aaa ctc tac 1646 Val Gln Ala Leu Ile Asp Ala Cys Glu Asp Gly Lys Leu Tyr 515 520 525 ctt tgt gta tca agt ccc act atc aag gat aag cca gtc cag att cgg 1694 Leu Cys Val Ser Ser Pro Thr Ile Lys Asp Lys Pro Val Gln Ile Arg 530 535 540 cct tgg aat ctc agt gac agt gac ttt gtg atg gat ggt tca cag cca 1742 Pro Trp Asn Leu Ser Asp Ser Asp Phe Val Met Asp Gly Ser Gln Pro 545 550 555 ctt gac cca cga aaa act ata ttt gtt ggt ggt gtt cct cga cca tta 1790 Leu Asp Pro Arg Lys Thr Ile Phe Val Gly Gly Val Pro Arg Pro Leu 560 565 570 cga gct gtg gag ctt gcg atg ata atg gat cgg cta tat gga ggt gtg 1838 Arg Ala Val Glu Leu Ala Met Ile Met Asp Arg Leu Tyr Gly Gly Val 575 580 585 585 590 tgc tac gct ggg att gat acc gac cct gag cta aaa tac cca aaa gga 1886 Cys Tyr Ala Gly Ile Asp Thr Asp Pro Glu Leu Lys Tyr Pro Lys Gly 595 600 605 gct ggg aga gtt gcg ttc tct at caa cag agt tac ata gct gct atc 1934 Ala Gly Arg Val Ala Phe Ser Asn Gln Gln Ser Tyr Ile Ala Ala Ile 610 615 620 agt gcc cgc ttt gtt cag ctg cag cat gga gag ata gat aaa cgg gtg 1982 Ser Ala Arg Phe Gln Leu Gln His Gly Glu Ile Asp Lys Arg Val 625 630 635 gaa gtt aag cca tat gtc ttg gat gat cag ctg tgt gat gaa tgt cag 2030 Glu Val Lys Pro Tyr Val Leu Asp Asp Gln Leu Cys Asp Glu Cys Gln 640 6 45 650 ggg gcc cgt tgt ggg ggg aaa ttt gct cca ttt ttc tgt gct aat gtt 2078 Gly Ala Arg Cys Gly Gly Lys Phe Ala Pro Phe Phe Cys Ala Asn Val 655 660 660 665 670 acc tgt ctg cag tat tac tgt gaa tat tg gct gct atc cat tct 2126 Thr Cys Leu Gln Tyr Tyr Cys Glu Tyr Cys Trp Ala Ala Ile His Ser 675 680 685 cgt gct ggc agg gaa ttc cac aag ccc ctg gtg aag gaa ggc ggt gac 2174 Arg Ala Gly Ars Glu Pro Leu Val Lys Glu Gly Gly Asp 690 695 700 cgc cct cgg cat att tca ttc cgc tgg aac taaaggataa ctgcagtgct 2224 Arg Pro Arg His Ile Ser Phe Arg Trp Asn tt 710 710 cattttcagg cctcagaata agtgc tctgcctc ct ctg cctc tctacctc tctgcctc tctgcc tgacctataa tataggtgtt ttgtagattc ttgtgtcact gcaaacaata tgaactcctt 2404 tttcgtattg ccatcgggtt gcatggaagt tttattctct tgttttgctg gaaaccaaga 2464 ggatccatac ttcctgcaattaatt attcctagatag aggattagatta tagatagatagatta tagatagatagatta tagato aaataacca tgcaacaata acactatcgg tctatctgac agtttttccc 2644 ccagggaagt gcttttgcct tttcctttct tttttttttt tttttcatct tttttgtctc 2704 tctctttttt ccatcccttt ttaatttttt taacagcaat ggaggaagtt aacaattttt 2764 aatggaaaga gcatgttaga gcaaacaaat gcataagcaa gactgagcag cattataatt 2824 aattttcagg gttttgaggc tgaacataat ttcattatcc ctcaaaaagt taccaccaca 2884 tcagaaaaaa taaaaaaaaa atagtaaagt aggcagagct aggtttattt tctcttaaac 2944 aatttttaaa attcagaatg taaaaattgg gtaaatttac tactgagggg agtgcactta 3004 tttatttaac ttacttatct ggtcaaagcc ccaggaaacc taccaaagct agaattaatg 3064 acaactggtg ggaaacctag catttcctct cctgaagaat aaatgtataa atgttatttt 3124 tgatgtttat atataaactc tatatcctaa tttactaata ctcatcagat gtcagccttt 3184 gctctccatt ttgacgttaa aaaacaacaa cagatctaga gatacctcaa ggatatcatt 3244 tttgattttg tgttacagta cacttgtagc caaaactgga agacaaaacc aatatataat 3304 ttggctgctg attggcttac ttttagattt aaagttactt tgggtatcct gtaatttagt 3364 tgtaacatag aaaatgaaaa aacagttaaa aaaagtgaag tagttgcaaa gtgttttgca 3424 ctgttgaact aagtaac tgt gtaaatctgt gcaaaggtac gtatgtttat cttactcttc 3484 ctataaacta aaataacatt acagtttccg aatttagcat gggacatagt cagtgtttga 3544 agtgccaact tcatcaagta atgcatgctt tattataaat aaaattctag ctttgaaagg 3604 cgttatgtgt tgaacagtat gcttcagggg taaatttaaa atagtctctt gaagccctag 3664 tcatggaagt aacttttatt ttaattgaca ttctcttatt aaatgcccta tccatcatta 3724 aaaggtttat tatcagtggg caaaacatga aataatatga tcgaatggca atcttgctag 3784 ttgcgctacc taacagtacc atcttggatc cttcaaaacc aaagacttgc cccagcactg 3844 ctgtggaacc acctggctta tgacccctat ggatgatctt taggaaaagc agccctttac 3904 ttttaataca ggctttaatg aactatacct gttaagttcc aaaggtcaaa atggaggcat 3964 ttgctgtcta atattcaaac atagaaaggg agctgctttt aaagaattcc ctgcaaatac 4024 tgaaagcagt catgcgaatg gagggtgctc ttgtgtagct ggtcagggac tttttttttc 4084 ttttctcctg aactacatga ttctaattgg aatgttcatt tgcctctttt tactctttta 4144 aatgcttgta ggtggcttgg ggtgtgctat cgtgctgttc ctactcagta aacaggtgtg 4204 atgagttaac aagaaataac actgtttgag aactagcttt gaataataat ttttcccttt 4264 gtacatgacc tgctgaattt c ggtacagtg tttttgtagc taacttattt tgtcatgcac 4324 ataatgtata tttgttatgc actacttttg tatatcttgt ttttccaaca gtgaacattt 4384 ttaggcacac ttttcactga cgggatatct ctttatgcaa tacctcaatt tttcatattg 4444 caaagagtag ctttttgtac ttttattact gagagatctt catatacttc attttttaat 4504 ataaataatt ttaataaatt ttattttctt atattccgct ttttatacat ttcagtgctc 4564 tgcatacatt ttaaattatg aatgtcgtgc actggcaatg ctattttaga gtctgcagag 4624 aagagaaagc atgttgctta aacatccttc cccagcacca gctattggtg tacctataat 4684 ttaagaaata gtctatgtaa agtcacaaat taatgaaaaa aattcgcatg aaaatgacag 4744 ataacactgt agttcctaaa aaaaaaatta aatgcataag cataaggtag aaattaaaat 4804 aacaaaattg tctacagctt cttactaagt ttttaaaatt attcataaaa tgcagacatt 4864 tttggtgaat gtttagccat ttttaatatt aataaattga tgttaagtgt ttgattcaga 4924 gatgtctgct cttttaaatt atatataagg aaaaaaaata gcctgccttg ggacaggtgt 4984 gtaatgttag tgtgcatgac taatgtaaga aattgttatt ctactaatat ttacttgtga 5044 ttgtgtgaca agtgtgttta cagattattg gttacacttc aatttacagg gcataaacaa 5104 tgattatcta ttactctgaa ctttatg att acatgttctt cagattacat gggattgtag 5164 ttgggagtta ccatgtaact caaacataat taacatgtaa ttagtttaca gattgtaggg 5224 catcacttca attcaccaag catgtagttc tagcgcacta gcatggtgcc agccatgtac 5284 ttacaatgta gttacagagt aattacatgg tgatttttgc aatgtaaaat aaagtgtttc 5344 tgattatttt ctatgtaaag gaaccctctc ctttcccctt ctggtccctg cgctttggta 5404 taatatatat acttctccat acacagacct ctgcagaatg caaaataaaa cttgcagtga 5464 atgaatttag cattttatga gagtgctgtt ggaaagactt gataattcac cccttttgtt 5524 ttgaagagtt gaatcttctg ttaaaaggtg atttaaaact tgaatgtgat gaattgtggc 5584 aagttaactt caagttatgt gcaatactta tttcaaactt ttgaaagatc tttgcagtgt 5644 aattctttgt ttttaattgc agacatttaa aaatgtcatt ttctactgtt aagagtaatc 5704 ctctttcttg ctggtgtttc taaagaaaag aatcagaaat caatctttct actaatgtaa 5764 atttgagatt atttttaaaa atggaataaa agaggttttg gtcatttgct ttattttatt 5824 attttaaagc tactgtgatt gatagcattg taagaatcgg gacaatattg tattcaactg 5884 ttttattttt tatattttta aaatttaaag tataattagt ttttataatt ttcatcagat 5944 ttttgttata ttttttggaa gtgaaacttt t agcaagtgg gtgtctagtt tttactaatc 6004 cctaattttt tttccagtgt attgctcata ttatcagaag gaaaagttat ttaagtatgt 6064 cagttaattg tactacttgg ctgaatttcc atatagtttt tactgtgtat ggggaggttg 6124 tagtatttat tatagcattt taaataaggg taattcattt tttattaaag tcattttcac 6184 gttaagttcc tatttttgta tgttctactc ttaagttata taacacagtt ccttttttaa 6244 aagagttcat ttgttgaagt gctagtgaaa aattaatgtt attaaatagt ttgcaaatga 6304 ctatttatac cagtatgcat ataattttta aatatttgta atgtgagatg ttgaatgaat 6364 aaaactttta actcag 6380 <210> 2 <211> 6970 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (984) .. (1391) <400> 2 cagcctaagg cctcatgtga tgaggtgggc tctccacaag ttcccggggc agagtctgaa 60 gacctgctgc tggatagggg cttcctcctg gtccccaagg gcccgccctc tcaggcccac 120 cttgaggcca ccctgctggg ccacttcccg gattttggac agcattgatt ggagccgccc 180 gttctcctcc tgtaggaccc ggatgcggat gtcgttggcc tgcacttgcc tctccatgtg 240 atctgtgacg ttgccagagt ctgtgggaca tgttatctgg gattccacgc tgctggatct 300 gcctcctgtg cccaatggga caggacctta gaagggaggc acaccagctt gggcaggtgg 360 cctggaggca caaaggagct gtgtagtgca ccaggcctcc tagctcatct tccttctccc 420 gaggccttat tcccccttcc ctgtccccca acctgcaggg aagatgacca tagtattata 480 aaatctgaga gctgggtggg acctagagct ctcaaaagac ttagcaaggc cgggcgcggt 540 ggctcacgcc tgtaatccca gcactttggg aggcccaggt caggggatca ttaagtcaag 600 agatcaagac catcctggcc aacatggtga aaccccgtct ctactaaaaa tagaaaaatg 660 agctgggtgt ggtggcgggc ccccgtagtc ccagctactc aggaggctga ggcaggagaa 720 tcacttgaac ccaggaggtg gaggttgcag tgagcagaga ttgtgccact gcactccagc 780 ctggcaacag agtgagactc tgtctcaaaa aaaaaaaaaa aaaaaaagac ttagcaaata 840 agcatgagag g agagtgaat ctctgacaag gccccccgtt ttggacaggc tacagccaaa 900 gtgagctgtc caaggtcaca cggccagctc aagcttggga acggcaggaa ttccgccagg 960 ctgctcttcc cctgcttttg tga tgg atg ctt cct tct ggc tcc agg agc ccg 1013 Trp Met Leu Pro Ser Gly Ser Arg Ser Pro 1 5 10 gga gaa ttg ctg ccc ctt ctg gtt cag ttt cct gct atg gga aat agc 1061 Gly Glu Leu Leu Pro Leu Leu Val Gln Phe Pro Ala Met Gly Asn Ser 15 20 25 tat ggg gct atg acc tgc ctc aca agg tgg ttg aga agg gga cag aag 1109 Tyr Gly Ala Met Thr Cys Leu Thr Arg Trp Leu Arg Arg Gly Gln Lys 30 35 40 ggc ctg gat gat gtc tca cga gca gct aac tgc aca tct tcc tgc cag 1157 Gly Leu Asp Asp Val Ser Arg Ala Ala Asn Cys Thr Ser Ser Cys Gln 45 50 55 ctc tgc aaa tgg att tgc cct agt gct tta ggg gtc tgg agg ggc tgg 1205 Leu Cys Lys Trp Ile Cys Pro Ser Ala Leu Gly Val Trp Arg Gly Trp 60 65 70 gag aac cca ggt cac ctg ata tcc aat cct gtg cca aga tgg gta 1253 Glu Asn Pro Gly His Leu Ile Ser Asn Pro Val Pro Arg Trp Val Pro 75 80 85 90 agc act cct atg cca tgg ggt cca gga cag t gg gca gct gga ggc tgt 1301 Ser Thr Pro Met Pro Trp Gly Pro Gly Gln Trp Ala Ala Gly Gly Cys 95 100 105 gtc ctt ggg act agt ccc atg gtg tgg ttt ggg gac cca ttc caa gaa 1349 Val Leu Gly Thr Ser Pro Met Val Trp Phe Gly Asp Pro Phe Gln Glu 110 115 120 cca aga agg ggg aca cac aga agt cga gca aga att agc atg 1391 Pro Arg Arg Gly Thr His Arg Ser Arg Ala Arg Ile Ser Met 125 130 135 135 1451 gtgactagag gcagtcacat cactgttggg ctttcacgtc cctgtctatg cagagtggat 1511 gacgcatgaa gcacttgcgt gctgtggtgg gtccacaggg gctgcgctgc tggccgcctg 1571 gctttaacac ccttgctgca ggctagggag ctgcagtccc cagtgtcctg cccacacgag 1631 ccctcagctg ctggccctga gccccagcat gcccttggca ccatccccag tcccctacca 1691 tggatctggg tctcggtggg cctgtgcagg tctgggaagg ccaccagcag ccgctcccgc 1751 tccttcagct cctccagctc ccgttctagc tccaggatgg ttagccgcag gtccgtagtc 1811 gcctgctcca ggccttgctt ctccctctgc aggctctgca gcagctcctg ggacagacgg 1871 aggctcaggc ctggctcctg agtgagctac atggtactca gcgccctggg gcaccgtccc 1931 tacccaagaa aagacatggg acaggcctgc aggcactcag ttggccggag acttctctgg 1991 caaaaaggaa gacccccacc ctcacctgct gggccctgag ctggcattgc ccctgctccc 2051 gctcgctctg cagctgctcc tccacgcggg cccgctgggc ctcagcctcg tccaggctgc 2111 cccgcagctc ctcacgttcc tggtccaggc tgtccagctg ctttagcagg gctcgctgct 2171 tggcctgcag agactaagca ggaacggaca agcagggagg ctgtgagacc cacagggcta 2231 ggcccagcca tgtggaacta aggaggctac agcatctact acccctcggc tgctaccccc 2291 ctggggtgtg tgtctgtgtc tagggaatgc tggtcacatg cgtggaaggg taggggtcgg 2351 gggaagctgg cagcaggcag atgcacaccg gacctggtca aggccaggat cccagcttga 2411 agaccccggc ccttggaacg cagatggctg gctctggggg tctcaccccc acttccttcc 2471 agtcatacac agaccccact tggagaggaa ttctgggaac taagtttttc ttctcctcgg 2531 gtctccagtg tcacatcatc ccatgttgct gaagcccaca tttcctaaca cccactgaat 2591 ggaaagcagg aagaactaac gctggactgc tcggagtcct ggctccacct ctcactagct 2651 gtgtggcctt gggcaacttc cttaacctca ctcaataagg ctgtttcctc attcgtaaaa 2711 tgggggtgac aagagtatct acctcctgtt gctgtagcga ggagtaagca tcaga ggctg 2771 cggcgcctga agcctgggtc acagcagaca cctgatacat ggcggctgtg acagtttgca 2831 aggcacagag aacagcaccc acttggggta gaaaggcttc ccctaccctg ggcccatgtc 2891 tgaccctggg gactctcaac tgaactcctg gctccttgct gagcttttga gggttagacc 2951 cagccaagac agcccccaga cctgcccctt tcactaggca ataggtcacc tactccctca 3011 accacacttc tgaggactcc tgtgaggccc cattgcccag agcacagcta tgccccgggc 3071 cctggctcac cctctgcctg ccctgtcctt cccctggctg atggactaat tgcctgtcat 3131 gggcgtccag ctcaaaggcc acctcctcct agaagccatt ctggattccc atggcagatg 3191 tggccatccc tccctgcacc ccttagccat ctggcaggag agtgtggcac acctgctcat 3251 ctttgcctgt ggggcgctct tccagagtga ggcctcactg ggcagtatca gtccctgggt 3311 cactgttccc ccagtgcctg gttcagggta gactctctgt aaaggtgagt caacccccac 3371 acctggaggc atctcaggga gcagatgccc aatatagatg atcccccatt ccctgacagt 3431 ggagccctct ttccctgcag cctacattgc agatgcccag gctagcgagg gccctggcct 3491 cacctcctgg tggcggacca tgctgtcgac acgggccttc tccttatcca gctccgtgct 3551 ggcccagcag acctgctggc cagcgccctc cagccgaccc accaacagct gcacctgcgc 3611 ctccaactgc tgcacctgct cctccagctg ctgcacctgc ctctccgctg ccgccctgcg 3671 ctcaccttcc tcctgcagct gctgggcctt tgcctctgca gcattaagtg gacatgggat 3731 ggggtagggc aggggagcgc tgtactacct cagacctagg acgggagctc acatcccatc 3791 tctgggcctc agagtcctca gccacaaaat ggggctctag accccacctg aggtgggttt 3851 ggaaaataga aggcgctttc tcggtaggag gtggcaaccc agtttggtca tcgccaatag 3911 tgtggttggt caggcccacc ctcctgtggc tggttccctt caactttgcc ctggatgctc 3971 aggggacaga gatggacgat gctcatccag ccacacccct ggcttgagat gtggcatggg 4031 ggcctatgat ggggctcctt acccacagcc tgtgtggact cccgctgctg tttcagttct 4091 ctctccaggg tggccatctt tgtctttagg tcacttgttt ctatggcagc caagagagag 4151 gcccttcaga gggtcccatg gacctggccg gcggccttca tgcccagtgt gccccgtgga 4211 gtggaggcag cccatcgcct gcagaggggc cgcctgcggc catgggagga gctctaggga 4271 ggctggtgga agcggctggg cccttaccca ccctgcttct catgggctgg ctgccatgtg 4331 tctacacctc tctgggcctt ggtgtcgtcc atggaggcaa ctgtgatgag gctcagaaag 4391 ggcaaatccc tcaggcctcc catcagtggg cactggccat cttctggtgc caggaacttt 4451 gtctctaatg gcttttgcca caaccagaga ggctgctctg cttggctgga agtgccaggg 4511 gaataactct ctggaagtag ccctcaatga ctgacagtgc aagtggatac atacctcggt 4571 tccctcactg accgatggac gagtctgggc aagcgtccta gcccagctcc tggtggcccc 4631 agtgggactg agatcacagt gtcaccaccg gatgaacacc cccttccttg ctgccctccc 4691 ttccctgcct cttgcctgtg tcccagcctg ggttcttcca cacaaaccac ttgccctgga 4751 agccctgtct cacaaacatc catgcaaagg ctgtggcaga gcccctgggc accaggcgtc 4811 tggcctctgg ggcacagacc tgtgagcagc tgctgtttgt cgtgctccca ctcagacagg 4871 cactgctcat cctcctccgc ctgtcgccgc cgtgccccct gctcctgttt cagcgcctgc 4931 tccagcttgc ccgcctgctt cctcaggcca tccttctgcc cttcagcctc ctccagctgg 4991 gccctgaggg cctccacatg cttactgagg cgcgtcaggt ctttcctctg ctctgctgcc 5051 cagcggccca cggtggcagc cggcagtggc ctgagcccca tgctgtcctg caccagttgc 5111 tggaactggc ctaaggacga gggcaggttc tggctctgac acaggctgat gaccaccttg 5171 cccaccttct gcaggcttcc ctggacgctg gcgcatgcgt cacagggcac cagggccgtc 5231 tcaatggtct gggagtggac actcctggtg ttcttgaagg tcgtggctgg gaactgcagg 5291 gaggct ctga cagggatgct ctctggctct tggcaggtct ggggcaagcc tagcactggg 5351 gaggagggct tgattaactt ggtagtcaga tattcagggc tcctggctgg ctcgcccttg 5411 gtggtgggct tggaggtggg agtctccctt tggtttgccc ctttctgtgt tcagaaaaag 5471 acaagggaaa gcaggtgagg gagagagtag agagggaggt gactggttcc ctgggggatg 5531 ttctgtgaca gtgtgacagc cttgcctgac actcagaccc tcaaatgttc tctgacaccg 5591 acgtgaataa gagagaactt tctccctctg ttactctgac tcagcttact acagccaggt 5651 ctcctctctg cggcccgcac cccaagctcc aggcttgatc tgattgtatg catggtgttg 5711 ggaaggtgat ggtgacggtc acagctgctg gttactgggc tcttgcttac tggacctgcc 5771 tgctcttgtg tcaccataac cactctcagt tttagtttcc ttcccatcat gggaacagtg 5831 gttcttcccc agtgggtggt tgtgtggatt acgggatagc ctataacaaa caggggtcac 5891 atgacctccg ttgtatagat gaagaaactg cggttcaaag taggcaagat ttttccaaag 5951 tcccacaggg atgtcagagc cagggagcaa ggcatgatcc ccaaggcctg cgttcttaac 6011 cgccacactg tgtggggctt gattgggagg gcggtgggag ccagtaaagg ctgtggtgca 6071 catagtggta ggctaggaag ccagagctgg ggcgaggtgt gaaggccacc acagtgggga 6131 gatagaggct gaggctgacc cacctgagac agaggctggg acccacctgg gggagtggct 6191 gctggtggag cgtgcccagc ctcagcaggc tgtcccagaa gcgccgcacc gtgagcccca 6251 cggacatgca gggccccgca gcctgtgcag ggggcatcat ctgctctgag ccaaggttct 6311 ccaagtagct catacagctt tgaagcagca gcaggagcct gcgggcagag atgctaggtt 6371 gctggggccc aggctggtgc taacataccc tcagaccata caaccgcagc tctggctctg 6431 gggaactggc ccaggcatca agagcttgga gagtctcaga atatgctctg ctgggccagc 6491 ttcaaaccta acccaggggc tacttcctca gggaagccct ccctggccac agcctcagct 6551 tgggagcctc ttctgtgtct cctgggtggc acttctgcct ggctcttctc cactggacca 6611 gggagctctg tgaagccagg cctggccttg cctcagttgt atcctgagtc cttgaaaagt 6671 tctgggtgaa tggctgcctt atatccagtg gcccggagcc tccacttgat agatgacaga 6731 gctgagaccc agagagggga agagcttgcc cacagacaca cattgatagg gcagagcagg 6791 gagtgtgcac agtctcctga ggctagtcag gggcttctgc agggtgagct gcttctgtga 6851 cagtggagac ctgtgtcaag acagctaggt ctctgtccta acctccaagt ttaaaactac 6911 agtcaggcat gaattgtaag aaaaaggagt attataataa aaagctaagt ttgcatttg 6970 <210> 3 <211> 6102 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1719) .. (5426) <400> 3 gcaggaagct tgcactaaat acatgagcac ctggtagtgc atcccttctg gatccaacca 60 gaggagacaa gctcccgcct accctctcta tatcacattt gcccaacacc tgtcacttgc 120 tttgaattaa acctccttct cacatttgat tctggcaacc atgcttagaa gtaaacagtt 180 caggcatatt tgctcccata gctggaagag gaaaacaagg atcagattgg agaagtgatt 240 tatctaagat cccacagtgg actgggagca gcactgagac ctcagcctag tctcctgatc 300 cccaagcagg gccctgccta aggaacacac tctgcagagt gctgggccaa agcagggttt 360 tccaactaat cttagaaggt aaagtccatg aaggtatgta ccagggattt ctgtttgttt 420 tgttcgtcac ttaatctcca gtgtctatgt cagtggctgg tatgtagtgg tgctcatgaa 480 gtatttgccg aatcaattaa agaattttcg gaaagagtga gtctcttgaa ctttgctacc 540 tactgtgacc ttggcccagc cccaggcctt gattcacaga ggcctgcaga gtctttcacc 600 tgattcttct gagtagctgg ggctcattct ttgcctgtct ttttctaggg tctccatttt 660 gggacattct aatccctgag cccctattat tttcatcatg ggcttctgcc tggctctagc 720 atggacactt ctggttgggg catggacccc tctgggagct cagaacccca tttcgtggga 780 ggtgcagcga tttgatgggt ggtacaacaa cctcatggag cacagatggg gcagcaaagg 840 ctcccggctg ca gcgcctgg tcccagccag ctatgcagat ggcgtgtacc agcccttggg 900 agaaccccac ctgcccaacc cccgagacct tagcaacacc atctcaaggg gccctgcagg 960 gctggcctcc ctgagaaacc gcacagtgtt gggggtcttc tttggctatc acgtgctttc 1020 agacctggtg agcgtggaaa ctcccggctg ccccgccgag ttcctcaaca ttcgcatccc 1080 gcccggagac cccatgttcg accccgacca gcgcggggac gtggtgctgc ccttccagag 1140 aagccgctgg gaccccgaga ccggacggag tcccagcaat ccccgggacc cggccaacca 1200 ggtgacgggc tggctggacg gcagcgccat ctatggttcc tcgcattcct ggagcgacgc 1260 gctgcggagc ttctccaggg gacagctggc gtcggggccc gaccccgctt ttccccgaga 1320 ctcgcagaac cccctgctca tgtgggcggc gcccgacccc gccaccgggc agaacgggcc 1380 ccgggggctg tacgccttcg gggcagagag agggaaccgg gaacccttcc tgcaggcgct 1440 gggcctgctc tggttccgct accacaacct gtgggcgcag aggctggccc gccagcaccc 1500 agactgggag gacgaggagc tgttccagca cgcacgcaag agggtcatcg ccacctacca 1560 gaacatcgct gtgtatgagt ggctgcccag cttcctgcag aaaacactcc cggagtatac 1620 aggataccgg ccatttctgg accccagcat ctcctcagag ttcgtggcgg cctctgagca 1680 gttcctgtcc accatggtg c cccctggcgt ctacatga gaa atg cca gct gcc act 1736 Glu Met Pro Ala Ala Thr 1 5 tcc agg ggg tca tca atc gga act caa gtg tct cca gag ctc tcc ggg 1784 Ser Arg Gly Ser Ser Ile Gly Thr Gln Val Ser Pro Glu Leu Ser Gly 10 15 20 tct gca aca gct act gga gcc gtg agc acc caa gcc tac aaa gtg ctg 1832 Ser Ala Thr Ala Thr Gly Ala Val Ser Thr Gln Ala Tyr Lys Val Leu 25 30 35 aag atg tgg atg cac tgc tgc tgg gca tgg cct ccc aga tcg cag agc 1880 Lys Met Trp Met His Cys Cys Trp Ala Trp Pro Pro Arg Ser Gln Ser 40 45 50 gag agg acc atg tgt tgg ttg aag atg tgc ggg gtg agt ctg agg ctg 1928 Glu Arg Thr Met Cys Trp Leu Lys Met Cys Gly Val Ser Leu Arg Leu 55 60 65 70 tcc ctg cag gtt gtg aac tcc tgg cct ctg gga aga ggc tca gct gga 1976 Ser Leu Gln Val Val Asn Ser Trp Pro Leu Gly Arg Gly Ser Ala Gly 75 80 85 ctt cca gaa cca gat ttc tgg cct ggg cca ctg aag ttt tcc cgc aca 2024 Leu Pro Glu Pro Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg Thr 90 95 100 gac cac ctg gcc agc tgc ctg cag cgg ggc cgg gat ctg ccc 2 072 Asp His Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu Pro 105 110 115 tct tac acc aag gcc agg gca gca ctg ggc ttg tct ccc att acc cgc 2120 Ser Tyr Thr Lys Ala Arg Ala Ala Leu Gly Leu Ser Pro Ile Thr Arg 120 125 130 tgg cag gac atc aac cct gca ctc tcc cgg agc aat gac act gta ctg 2168 Trp Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Asp Thr Val Leu 135 140 145 150 gag gcc aca gct gcc ctg tac aac cag gac tta tcc tgg cta gag ctg 2216 Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Trp Leu Glu Leu 155 160 165 ctc cct ggg gga ctc ctg gag agc cac cgg gac cct gga cct ctg Gly Leu Leu Leu Glu Ser His Arg Asp Pro Gly Pro Leu Phe 170 175 180 agc acc atc gtc ctt gaa caa ttt gtg cgg cta cgg gat ggt gac cgc 2312 Ser Thr Ile Val Leu Glu Gln Phe Val Arg Leu Arg Asp Gly Asp Arg 185 190 195 tac tgg ttt gag aac acc agg aat ggg ctg ttc tcc aag aag gag att 2360 Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Lys Glu Ile 200 205 210 gaa gaa atc cga aat acc acc ctg cag gac gtg ct g gtc gct gtt atc 2408 Glu Glu Ile Arg Asn Thr Thr Leu Gln Asp Val Leu Val Ala Val Ile 215 220 225 230 aac att gac ccc agt gct ctg cag ccc aat gtc ttt gtc tgg cat aaa 2456 Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Val Trp His Lys 235 240 245 gga gac ccc tgt ccg cag ccg aga cag ctc agc act gaa ggc ctg cca 2504 Gly Asp Pro Cys Pro Gln Pro Arg Gln Leu Ser Thr Glu Gly Leu Pro 250 255 260 gcg tgt gct ccc tct gtt gtt cgt gac tat ttt gag ggc agt gga ttt 2552 Ala Cys Ala Pro Ser Val Val Arg Asp Tyr Phe Glu Gly Ser Gly Phe 265 270 275 ggc ttc ggg gtc acc atc ggg acc ctc tgt tgc ttc cg ctg 2600 Gly Phe Gly Val Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val Ser 280 285 290 ctg ctc agt gcc tgg att gtt gcc cgg ctc cgg atg aga aat ttc aag 2648 Leu Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Met Arg Asn Phe Lys 295 300 305 310 agg ctc cag ggc cag gac cgc cag agc atc gtg tct gag aag ctc gtg 2696 Arg Leu Gln Gly Gln Asp Arg Gln Ser Ile Val Ser Glu Lys Leu Val 315 320 325 gga ggc atg gag gaa tgg caa ggc cac aag gag ccc tgc cgg 2744 Gly Gly Met Glu Ala Leu Glu Trp Gln Gly His Lys Glu Pro Cys Arg 330 335 340 ccc gtg ctt gtg tac ctg cag ccc ggg cag atc cgt gtg gta gat Legg 2 Val Tyr Leu Gln Pro Gly Gln Ile Arg Val Val Asp Gly 345 350 355 agg ctc acc gtg ctc cgc acc atc cag ctg cag cct cca cag aag gtc 2840 Arg Leu Thr Val Leu Arg Thr Ile Gln Leu Gln Pro Pro Gln Lys Val 360 365 370 aac ttc gtc ctg tcc agc aac cgt gga cgc cgc act ctg ctg ctc aag 2888 Asn Phe Val Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu Lys 375 380 385 390 atc ccc aag gag tt gt ctg gt g ctg g aac ttg gag gaa gag 2936 Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Leu Glu Glu Glu 395 400 405 cgg cag gcg ctg gtg gaa aat ctc cgg gga gct ctg aag gag agc ggg 2984 Arg Glu Ala Leu Arg Gly Ala Leu Lys Glu Ser Gly 410 415 420 ttg agc atc cag gag tgg gag ctg cgg gag cag gag ctg atg aga gca 3032 Leu Ser Ile Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg Ala 425 430 435 gct gtg aca cgg gag cag cgg agg cac ctc ctg gag acc ttt ttc agg 3080 Ala Val Thr Arg Glu Gln Arg Arg His Leu Leu Glu Thr Phe Phe Arg 440 445 450 cac ctt ttc tcc cag gtg ctg gac atc aac cag gcc gac acc 3128 His Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly Thr 455 460 465 470 ctg ccc ctg gac tcc tcc cag aag gtg cgg gag gcc ctg acc tgt gag 3176 Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu Ala Leu Thr Cys Glu 475 480 485 ctg agc agg gcc gag ttt gcc gag tcc ctg ggc ctc aag ccc cag gac 3224 Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly Leu Lys Pro Gln Asp 490 495 500 atg ttt gtg gag ttc tct ctg gct gac aag gat ggc aat ggc 3272 Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn Gly 505 510 515 tac ctg tcc ttc cga gag ttc ctg gac atc ctg gtg gtc ttc atc yr gtc gtc gtc gtc yr Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met Lys 520 525 530 ggc tct cct gag gaa aag tct cgc ctt atg ttc cgc atg tac gac ttt 3368 Gly Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp Phe 535 540 545 550 gat ggg aat ggc ctc att tcc aag gat gag ttc atc agg atg ctg aga 3416 Asp Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu Arg 555 560 565 565 tcc ttc atc gac atc tcc ctg tcc aag gcc cag ctg gct 3464 Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu Ala 570 575 580 gag gtg gtg gag tcc atg ttc cgg gag tcg gga ttc cag gac aag gag 3512 Glu Val Glu Val Phe Arg Glu Ser Gly Phe Gln Asp Lys Glu 585 590 595 gaa ctg aca tgg gaa gat ttt cac ttc atg ctg cgg gac cac aat agc 3560 Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asn Ser g 610 605 ctc cgc ttc acg cag ctc tgt gtc aaa ggg gtg gag gtg cct gaa 3608 Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro Glu 615 620 625 630 gtc atc aag gac ctc tgc cgg cga gcc tcc gat atg 3656 Val Ile Lys Asp Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Asp Met 635 640 645 atc tgt ccc tct ccc aga gtg agt gcc cgc tgt tcc cgc agc gac att 3704 Ile Cys Pro Ser Pro Arg Val Ser Ala A rg Cys Ser Arg Ser Asp Ile 650 655 660 gag act gag ttg aca cct cag aga ctg cag tgc ccc atg gac aca gac 3752 Glu Thr Glu Leu Thr Pro Gln Arg Leu Gln Cys Pro Met Asp Thr Asp 665 670 675 675 cct ccc cag gag att cgg cgg agg ttt ggc aag aag gta acg tca ttc 3800 Pro Pro Gln Glu Ile Arg Arg Arg Phe Gly Lys Lys Val Thr Ser Phe 680 685 690 cag ccc ttg ctg ttc act gag gcg cac cga gag aag ttc caacgg gag ag Pro Leu Leu Phe Thr Glu Ala His Arg Glu Lys Phe Gln Arg Ser 695 700 705 710 tgt ctc cac cag acg gtg caa cag ttc aag cgc ttc att gag aac tac 3896 Cys Leu His Gln Thr Val Gln Gln Phe Lys Arg Phe Ile Glu Asn Tyr 715 720 725 cgg cgc cac atc ggc tgc gtg gcc gtg ttc tac gcc atc gct ggg ggg 3944 Arg Arg His Ile Gly Cys Val Ala Val Phe Tyr Ala Ile Ala Gly Gly 730 735 740 740 ctt ttc ctg gag agg gac tg gcc ttt gcc gca cat cac acg 3992 Leu Phe Leu Glu Arg Ala Tyr Tyr Tyr Ala Phe Ala Ala His His Thr 745 750 755 ggc atc acg gac acc acc cgc gtg gga atc atc ctg tcg cgg ggc aca 4040 Gly Ile Thr Asp T hr Thr Arg Val Gly Ile Ile Leu Ser Arg Gly Thr 760 765 770 gca gcc agc atc tct ttc atg ttc tcc tac atc ttg ctc acc atg tgc 4088 Ala Ala Ser Ile Ser Phe Met Phe Ser Tyr Ile Leu Leu Thr Met Cys 775 780 785 790 cgc aac ctc atc acc ttc ctg cga gaa acc ttc ctc aac cgc tac gtg 4136 Arg Asn Leu Ile Thr Phe Leu Arg Glu Thr Phe Leu Asn Arg Tyr Val 795 800 805 ccc ttc gac gcc gcc gtg gac ctc gcttc gcc tcc acc gcc 4184 Pro Phe Asp Ala Ala Val Asp Phe His Arg Leu Ile Ala Ser Thr Ala 810 815 820 atc gtc ctc aca gtc tta cac agt gtg ggc cat gtg gtg aat gtg tac 4232 Ile Val Leu Thr Val Leu His Ser Val Gly His Val Val Asn Val Tyr 825 830 835 ctg ttc tcc atc agc ccc ctc agc gtc ctc tct tgc ctc ttt cct ggc 4280 Leu Phe Ser Ile Ser Pro Leu Ser Val Leu Ser Cys Leu Phe Pro Gly 840 845 850 850 ctc ttc gat ggg tct gag ttc ccc cag aag tat tac tgg tgg 4328 Leu Phe His Asp Asp Gly Ser Glu Phe Pro Gln Lys Tyr Tyr Trp Trp 855 860 860 865 870 ttc ttc cag acc gta cca ggc ctc acg ggg gtt gtg ctg ctg ctg ctg cc 4376 Phe Phe Gln Thr Val Pro Gly Leu Thr Gly Val Val Leu Leu Leu Ile 875 880 885 ctg gcc atc atg tat gtc ttt gcc tcc cac cac ttc cgc cgc cgc agt 4424 Leu Ala Ile Met Tyr Val Phe Ala Ser His His Phe Arg Arg Arg Ser 890 895 900 ttc cgg ggc ttc tgg ctg acc cac cac ctc tac atc ctg ctc tat gtc 4472 Phe Arg Gly Phe Trp Leu Thr His His Leu Tyr Ile Leu Leu Tyr Val 905 910 915 915 ctg ctc atc atc gt g gcc ctg atc cag ctg ccc cgt ttc 4520 Leu Leu Ile Ile His Gly Ser Phe Ala Leu Ile Gln Leu Pro Arg Phe 920 925 930 cac atc ttc ttc ctg gtc cca gca atc atc tat ggg ggc gac aag ctg 4he Val Pro Ala Ile Ile Tyr Gly Gly Asp Lys Leu 935 940 945 950 gtg agc ctg agc cgg aag aag gtg gag atc agc gtg gtg aag gcg gag 4616 Val Ser Leu Ser Arg Lys Lys Val Glu Ile Ser Val Val Lys Ala Glu 95 965 ctg ctg ccc tca gga gtg acc cac ctg cgg ttc cag cgg ccc cag ggc 4664 Leu Leu Pro Ser Gly Val Thr His Leu Arg Phe Gln Arg Pro Gln Gly 970 975 980 ttt gag tac aag tca ggg cag tgg gtg cgg atc gct tgc ctg gct ctg 4712 Phe Glu Tyr Lys Ser Gly Gln Trp Val Arg Ile Ala Cys Leu Ala Leu 985 990 995 ggg acc acc gag tac cac ccc ttc aca ctg acc tct gcg ccc cat gag 4760 Gly Thr Thr Glu Tyr His Pro Phe Thr Leu Thr Ser Ala Pro His Glu 1000 1005 1010 gac acg ctt agc ctg cac atc cgg gca gca ggg ccc tgg acc act cgc 4808 Asp Thr Leu Ser Leu His Ile Arg Ala Ala Gly Pro Trp Thr Thr Arg 1015 1020 1025 1030 ctc agg gag atc tac tca gcc ccg acg ggt gac aga tgt gcc aga tac 4856 Leu Arg Glu Ile Tyr Ser Ala Pro Thr Gly Asp Arg Cys Ala Arg Tyr 1035 1040 1045 cca aag ctg tac ctt gat gga cca ttt gga gag ggc cac cag gag 4904 Pro Lys Leu Tyr Leu Asp Gly Pro Phe Gly Glu Gly His Gln Glu Trp 1050 1055 1060 cat aag ttt gag gtg tca gtg tta gtg gga ggg ggc att ggg gtc acc 4952 His Lys Phe Glu Val Ser Val Leu Val Gly Gly Gly Ile Gly Val Thr 1065 1070 1075 cct ttt gcc tcc atc ctc aaa gac ctg gtc ttc aag tca tcc gtc agc 5000 Pro Phe Ala Ser Ile Leu Lys Asp Leu Val Phe Lys Ser Ser Val Ser 1080 1085 1090 tgc ca a gtg ttc tgt aag aag atc tac ttc atc tgg gtg acg cgg acc 5048 Cys Gln Val Phe Cys Lys Lys Ile Tyr Phe Ile Trp Val Thr Arg Thr 1095 1100 1105 1110 cag cgt cag ttt gag tgg ctg gct gac atc atc cgag gag gag 5096 Gln Arg Gln Phe Glu Trp Leu Ala Asp Ile Ile Arg Glu Val Glu Glu 1115 1120 1125 aat gac cac cag gac ctg gtg tct gtg cac atc tac atc acc cag ctg 5144 Asn Asp His Gln Asp Leu Val Ser Val His Ile Tyr Ile Thr Gln Leu 1130 1135 1140 gct gag aag ttc gac ctc agg acc act atg ctg tac atc tgt gag cgg 5192 Ala Glu Lys Phe Asp Leu Arg Thr Thr Met Leu Tyr Ile Cys Glu Arg 1145 1150 1155 cac ttc cag aag gtt aac cgg agt cta ttc aca ggc ctg cgc tcc 5240 His Phe Gln Lys Val Leu Asn Arg Ser Leu Phe Thr Gly Leu Arg Ser 1160 1165 1170 atc acc cac ttt ggc cgt ccc ccc ttt gag ccc ttc ttc aac tcc ctg 5288 I Phe Gly Arg Pro Pro Phe Glu Pro Phe Phe Asn Ser Leu 1175 1180 1185 1190 cag gag gtc cac ccc cag gtc cgg aag atc ggg gtg ttt agc tgt ggc 5336 Gln Glu Val His Pro Gln Val Arg Lys Il e Gly Val Phe Ser Cys Gly 1195 1200 1205 ccc cct ggc atg acc aag aat gtg gaa aag gcc tgt cag ctc atc aac 5384 Pro Pro Gly Met Thr Lys Asn Val Glu Lys Ala Cys Gln Leu Ile Asn 1210 1215 1220 agg cag gac cgg act cac ttc tcc cac cat tat gag aac ttc 5426 Arg Gln Asp Arg Thr His Phe Ser His His Tyr Glu Asn Phe 1225 1230 1235 taggcccctg cccgggggtt ctgcccactg cccagttgag cagaggtttg agcccacacc 5486 tcacctctgt tcttcctatt tctggctgcc tcagccttct ctgatttccc acctcccaac 5546 cttgttccag gtggccatag tcagtcacca tgtgtgggct cagggacccc caggaccagg 5606 atgtgtctca gcctggagaa atggtggggg ggcagtgtct agggactaga gtgagaagta 5666 ggggagctac tgatttgggg caaagtgaaa cctctgcttc cagacttcag aaacaaatct 5726 cagaagacaa gctgacctga caagtactat gtgtgtgcat gtctgtatgt gtgttggggc 5786 ggtgagtgta aggatgcagt gggagcatgg atgctggcat cttagaaccc tccctactcc 5846 cagacctcct cctcttctgg gctccccact gtcagacggg ctggcaaatg ccttgcagga 5906 ggtagaggct ggacccatgg caagccattt acagaaaccc actcggcacc ccagtctaac 5966 accacaacta atttcaccca aggttttaag cacgttc ttt catcagaccc tggcccaata 6026 cctatgtatg caatgctcct cagccctctt ctccctgctc cagtagtctc ccttccaaat 6086 aaatcacttt tctgcc 6102 <210> 4 <211> 6235 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (50) .. (1414) <400> 4 gcggcggcgg cgcagccggt tccgggttcg gcgcggggcg gggatgtga atc ccg atg 58 Ile Pro Met 1 gag cgg ccc gag gaa ggc aag cag tcg ccg ccg ccg cag ccc tgg gga 106 Glu ArG Pro Glu G Pro Glu G 5 10 15 cgg ctc ctg cgt ctg ggc gcg gag gag ggc gag ccg cac gtc ctc ctg 154 Arg Leu Leu Arg Leu Gly Ala Glu Glu Gly Glu Pro His Val Leu Leu 20 25 30 35 agg aag cgg gag tgg acc atc ggg cgg cga ggt tgc gac ctt tcc 202 Arg Lys Arg Glu Trp Thr Ile Gly Arg Arg Arg Gly Cys Asp Leu Ser 40 45 50 ttc ccc agc aat aaa ctg gtc tct gga gat cac tgt aga att gta gtg 250 Phe Pro Ser Asn Lys Leu Val Ser Gly Asp His Cys Arg Ile Val Val 55 60 65 gat gaa aaa tca ggt cag gtg aca ctg gaa gat acc agc acc agt gga 298 Asp Glu Lys Ser Gly Gln Val Thr Leu Glu Asp Thr Ser Thr Ser Gly 70 75 80 aca gtg att aac aag ctg aag gtt gtt aag aag cag aca tgc cct tta 346 Thr Val Ile Asn Lys Leu Lys Val Val Lys Lys Gln Thr Cys Pro Leu 85 90 95 cag act ggg gat gtc atc tac ttg gtg tac agg aag aat gaa ccg g aa 394 Gln Thr Gly Asp Val Ile Tyr Leu Val Tyr Arg Lys Asn Glu Pro Glu 100 105 110 115 cac aac gtg gca tac ctc tat gaa tct tta agt gaa aag caa ggc atg 442 His Asn Val Ala Tyr Leu Tyr Glu Ser Leu Ser Glu Lys Gln Gly Met 120 125 130 aca caa gaa tcc ttt gaa gct aac aag gaa aat gtg ttc cat ggg acc 490 Thr Gln Glu Ser Phe Glu Ala Asn Lys Glu Asn Val Phe His Gly Thr 135 140 145 aaa gat acc tca ggt gca ggt gca ggg cga ggg gcc gat ccc cgg gtc 538 Lys Asp Thr Ser Gly Ala Gly Ala Gly Arg Gly Ala Asp Pro Arg Val 150 155 160 cct ccg tcg tcg ccc gcc act cag gtg tgc ttt gag gaa cca cag cca 586 Pro Pro Ser Ser Pro Ala Thr Gln Val Cys Phe Glu Glu Pro Gln Pro 165 170 175 tca aca tcg acg tca gac ctc ttc ccc aca gcc tcg gcc tct tcc acg 634 Ser Thr Ser Thr Ser Asp Leu Phe Pro Thr Ala Ser Ala Ser Ser Thr 180 185 190 195 gag cct tct cct gca ggg cga gag cgt tcc tcc agt tgt gag atg gtg 682 Glu Pro Ser Pro Ala Gly Arg Glu Arg Ser Ser Ser Cys Glu Met Val 200 205 210 ctt tgc tgt gtt gcc cgg gct ggt cta aaa ctc c tg gga tca agt gat 730 Leu Cys Cys Val Ala Arg Ala Gly Leu Lys Leu Leu Gly Ser Ser Asp 215 220 225 cct ccc gcc ttg gcc tcc caa agt gtt gtg att aca ggg tct ggg ggt 778 Pro Pro Ala Leu Ala Ser Gln Ser Val Val Ile Thr Gly Ser Gly Gly 230 235 240 ggt ggc atc tcc cct aaa gga agt ggt ccc tct gtg gca agt gat gaa 826 Gly Gly Ile Ser Pro Lys Gly Ser Gly Pro Ser Val Ala Ser Asp Glu 245 250 255 gtc tcc agc ttt gcc tca gct ctc cca gac aga aag act gcg tcc ttt 874 Val Ser Ser Phe Ala Ser Ala Leu Pro Asp Arg Lys Thr Ala Ser Phe 260 265 270 275 tcg tcg ttg gaa ccc cag gat cag gag gat ttg gag ccc gag ag 922 Ser Ser Leu Glu Pro Gln Asp Gln Glu Asp Leu Glu Pro Val Lys Lys 280 285 290 aaa atg aga gga gat ggg gac ctt gac ctg aac ggg cag ttg ttg gtc 970 Lys Met Arg Gly Asp Gly Asp Leu Asp Leu Asn Gly Leu Leu Val 295 300 305 gca caa ccg cgt aga aat gcc caa acc gtc cac gag gac gtc aga gca 1018 Ala Gln Pro Arg Arg Asn Ala Gln Thr Val His Glu Asp Val Arg Ala 310 315 320 gcg gct ggg aag cca gac aag atggag gag acg ctg aca tgc atc atc 1066 Ala Ala Gly Lys Pro Asp Lys Met Glu Glu Thr Leu Thr Cys Ile Ile 325 330 335 tgc cag gac ctg ctg cac gac tgc gtg agt ttg cag ccc tgc atg cac LepGu His Asp Cys Val Ser Leu Gln Pro Cys Met His 340 345 350 355 acg ttc tgc gcg gct tgc tac tcg ggc tgg atg gag cgc tcg tcc ctg 1162 Thr Phe Cys Ala Ala Cys Tyr Ser Gly Trp Met Glu Arg Ser Ser Leu 360 365 370 tgt cct acc tgc cgc tgt ccc gtg gag cgg atc tgt aaa aac cac atc 1210 Cys Pro Thr Cys Arg Cys Pro Val Glu Arg Ile Cys Lys Asn His Ile 375 380 385 385 ctc aac aac ctc gtg gaa gca tac catccag ca gac aag agt 1258 Leu Asn Asn Leu Val Glu Ala Tyr Leu Ile Gln His Pro Asp Lys Ser 390 395 400 cgc agt gaa gaa gat gtg caa agt atg gat gcc agg aat aaa atc act 1306 Arg Ser Glu Glu Asp Val Gln Ser Met Asp Ala Arg Asn Lys Ile Thr 405 410 415 caa gac atg ctg cag ccc aaa gtc agg cgg tct ttt tct gat gaa gaa 1354 Gln Asp Met Leu Gln Pro Lys Val Arg Arg Ser Phe Ser Asp Glu Glu 420 425 430 430 435 ggg agt tca gag gac ctg ctg gag ctg tca gac gtt gac agt gag tcc 1402 Gly Ser Ser Glu Asp Leu Leu Glu Leu Ser Asp Val Asp Ser Glu Ser 440 445 450 tca gac att agg taaatcatgc ccctggctca gagcagagtg tgtgagccagagaggagagagagcaggagcatcagagcagagagagagcagagcagagcagagcagagcagagagagagcagagcagagagagcaggagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagcagagcagagagagagagagagagagagagcagagagagaggagagagagagagagagagagagagagagagagag1ag1401Gca) tgagagctca ctactgggtg gacagcatgg gtcctgagat 1514 ctagttctgc cctgagcagc caagctctta aatggcttga gcttgttttc tgatattgga 1574 tagtattagc acctcccctg agaggcgtgg cagggactgg gtgaacactt agcggggtag 1634 ccagggggta gccagcagag cgtcagccgc aggcgactgc tgtagacatt tgcaccctcg 1694 gctgacaccc ttccctttgc ttcgactcgt catgggtgtg gcatctctgg ctgtgacaga 1754 gggacatcat tccatgttat tttttcccac atgagcacat gtattctttg tagttgatct 1814 agcgactata aagtcctata gtataaattg caatgtttat catttgtcag gacgttatta 1874 cagaagaggc accatcacca ggccaagaca atcccagcct cagagacctt atttatctgc 1934 tgacatgttg aggtttccta atgcacaaga ccggggtctg aatgttgggt cgaggccatg 1994 atatttaaaa agacaatgaa cgacaaaaaa aaacacttga aacttttatc tttatttccgactag catagagactag tattagcagagactag tattagccagagactag 14 ttaagatttt gctgcctcta cccagccatt catacgtgtg tcataatcgt taacaaaatg 2174 aaatgtaatg tactaacaaa tttttttttt cttttttttt tgagatggag tgtcgctctg 2234 ctgccaggct ggagtgcagt gacacgatct cagctcactg aaatcaccac ctcctgggtt 2294 caagcgattc tcctgcctca gcctctcgag tggctgggac tacaggcgca tgccaccaca 2354 cccagctaat ttttttgtat ttttagtaga gatggggttt taccacattg gccaggatgg 2414 ccttgatctc ctgacctcgt gatccgccgg cctcgacctc ccaaagtgct gggattacag 2474 gcatgagcca ctgcgccctg ccaatggcac aatcttggcg cattgcaacc tccgcctccc 2534 gggttcaagc gattctcctg cctcagcctc ccaaatagct gggattacag gcatgcacca 2594 ccaaacttgg ctaatttttt tttcttttct tttttttttt tttcgagaca aagtctcgct 2654 ctgttgccca ggctggagtg cagtggcatg accttcgccc actgcaacat tcatctcctg 2714 ggttcaagtg attctcccgt gttagcctcc cgaggggctg ggattacggg catatgccac 2774 cacacccagc taatttttgt gtttttagta aagacagagt ttcaccatgt tggccagact 2834 ggtctcgaaa tcctgacctc aagtgatccg tctgccttgg cctctcaaag tgctgggatt 2894 ataagtgtga gccaccgcgc ccggccgcta attttgtatt tttagtagag acagggtttc 2954 ac catgttgg ccaggctggt cttgaactcc tgacctcagg tgattagccc gcctcggcct 3014 cccaaagtgc tgggattata ggcgtgagaa acaaatttat tttttgtttg tttgtttttt 3074 gagatggagt ttcgctctgt tgcccaggct ggagtgcagt ggctggatct tggctcattg 3134 caagctccgc ctcccgagtt cacgccattt tcctgcctca gcctcccgag tagctgggac 3194 tacaggctcc cgataccatg cccggctaat tttttgtatt tttggtagag actgggtttc 3254 accgtgttag tcaggatggt cttgaactcc tgacctcgtg atccgcccgc ctcagcctcc 3314 caaagtgctg ggattacagg catgagaaac aaatattttt atgaagctgg gattcggctg 3374 catgtacagc tcggtaatgt ccccagcgtt tgaattggga aacagttgct gctgtgcatt 3434 tcttccatcc gtatttgtgc acatgcgcag tgacgtcaat gtttagacgt gaagcagtcg 3494 agtcacagag tgtgactggg aattggacct tgatagacgt ttgataagtt tgttatccag 3554 acaccgatcg gaaagggtgc acctaatgca ctctacaagg tctgcatgag ggcctctttt 3614 tgccagttta gaaggagaag taggtaatct cattttcatt tacatttttt ccttatgaaa 3674 aaaatgtctt ttcactgtgc cttgtttttt acctggttgg gtcttacctg ttggccttat 3734 tggcccctgg ccttggtgtg aggcgcagaa aagcctttca aatggagagg agagcctcgt 3794 gtatttt ttc ctacaggttc tttttttaca gttgacattt ttatctgctc gtttttggaa 3854 gtacaaggga agtgtagaaa agacaagtga ttcggggctt tgcaggcgcc tggtgtggct 3914 cccagtacgt tgcctaccgc gctctgcttt taacgggaga gtaggcgggt cctgaggagc 3974 acggggcgtg cgcgcacgtg ctggcccttg ccctgctctg gcgtcgtctc ctgggagcac 4034 acgtcagtgg ggacgtagtg accctgggga tggggctcca aagcgtgggg gctgagctgg 4094 ggatgcagag tggcgtgtcc ttgcccttcg actcgttctg gtccctctct aacactgggg 4154 tgctggacag gaatggggcc cggcccttcc cctcacacca agcagctgag cgacggtgga 4214 gctgagctgt gatggctgcg gacccgcgtt gcaccggccc tacctgagag gcttggggcc 4274 tgcacacagc tcggccctgt gcttccttgc agccagccat acgtcgtgtg ccggcagtgt 4334 cctgagtaca gaaggcaggc ggcgcagcct ccccactgcc cagcacccga gggcgagcca 4394 ggagccccac aggccctggg ggatgcaccc tccacgtccg tcagcctgac gacagtccag 4454 gattacgtgt gccctctgca aggaagccac gccctgtgca cctgctgctt ccagcccatg 4514 cccgaccgga gagcggagcg cgagcaggac ccgcgtgtcg cccctcagca gtgtgcggtc 4574 tgcctgcagc ctttctgcca cctgtactgg ggctgcaccc ggaccggctg ctacggctgc 4634 ctggccccgt tt tgtgagct caacctgggt gacaagtgtc tggacggcgt gctgaacaac 4694 aacagctacg agtcagacat cctgaagaat tacctggcaa ccagaggttt gacatggaaa 4754 aacatgttga ccgagagcct catggctctc cagcggggag tgtttctgct gtctgattac 4814 agagtcacgg gagacaccgt tctgtgttac tgctgtggcc tgcgcagctt ccgtgagctg 4874 acctatcagt atcggcagaa cattcctgct tccgagttgc cagtggccgt aacatcccgt 4934 cctgactgct actggggccg taactgccgc actcaggtga aagctcacca cgccatgaaa 4994 ttcaatcata tctgtgaaca gacaaggttc aaaaactaag catccagagg ccctgagcag 5054 ctttcagcac tggaggtgaa gagagcgtgt ttttaaaata cagagacaag cacgtcaagg 5114 tgttttcaca gccccctgag ggaagggacg cagggtctcc gacaggtgct ctggggtgac 5174 tcttctgtgg agctttaccc tctgagtgag accctcccca gagccccggg ggccgcagcc 5234 cgccctcctg gtgagcgctg ggcagggctc gtggtggcat cagcagcaga gacgaagcct 5294 ttctgtaaca tgcggccgtc ccgccgagag gggcagtttt gctcttttgt acattttccg 5354 aaactacagt taaagcagaa gtctgttttc aggaaaagtt tcaagggaga agggcaagtt 5414 tatcaaaaac attgtttcag gagaagggag cataagttta cagcctacag gacgtacaca 5474 atatcctgct gctggga aaa ccacagcatt ttatctattt tttattttaa taggtttggt 5534 gcttatcttc taataagatt taaatgtcac aaactgtagc acaaataata taatttataa 5594 tttacaaatt gactaaaatt gggtatagta tggtatttga aagaataagc atatgcttct 5654 gtttattaaa aaaagaaacc ttccaatgtc caaaactgct aaccctcgac gtggccgcca 5714 agttagtcgc tccttgctaa ccggtgagtg accgcggccc cgagcctggg gctggacgca 5774 ggtcccagga catgctgctc ccttgtgtga gtgaccacgg ccccgagcct ggggctggac 5834 gcaggtccca ggacgtgctg ctcccttgtg tgagtgacca cggccccaag cccagggctg 5894 gaggcaggtc ccaggacgcg ccgctccctc atgctgcccg ggcccttcct ccaagaccct 5954 acagagcctg aggggcacct tggcttccgc ctgtgctagc tttgccatgt catctggaat 6014 aatacttgaa attttgattt ttggaaaaaa aagtttttta tcttttgttg aaatcacctg 6074 ttatccttgt ttgtaaactg ataacttttt tgcttcttct caggaataca gttttcaact 6134 gttgtcttgc tcttgataga aactgagaag cagcaatctg tatttgtgga ggaaagtcct 6194 ctcttttgca tattctaata aatgagccgc gtttgctcct c 6235 <210> 5 <211> 6339 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (323) .. (628) <400> 5 cttggggatc tgagcatctg ggagcaggag gtggagggcc aggtgagcac acagctgcga 60 ggaggtggag gaccaggtga gcacacagct acagctacag ggaggctctg cgcctgcagg 120 acaggttatt acaggggccg cagcagggcc tgggccgcct ccactctgtt ggctggggtt 180 caggggtccc aggtcgccag gagcaccttg catgtggctc gggatgcacg gagtctcccg 240 tgaggtgtgg gtttcctagg accccagggc aggtgtccca tgggagtatg aactaaatgc 300 ctttgtggac gtttagacgt ga aat gtc tgc tct aga ctc aca cac ctg tct 352 Asn Val Cys Ser Arg Leu Thr His Leu Ser 1 5 10 cgc tcc ctc ctt cca gaa ctc tta aaa cgc cta gat gac gtg tcc aac 400 Arg Ser Leu Leu Pro Glu Leu Leu Lys Arg Leu Asp Asp Val Ser Asn 15 20 25 gat gtg agg atg gca gcc gcc tcc acc ttg gtc acc tgg ctg cag tgt 448 Asp Val Arg Met Ala Ala Ala Ser Thr Leu Val Thr Trp Leu Gln Cys 30 35 40 gtc aag ggt gcc aac gca aaa tcc tac tat cag agc agt gtc cag tac 496 Val Lys Gly Ala Asn Ala Lys Ser Tyr Tyr Gln Ser Ser Val Gln Tyr 45 50 55 ctg tac cga gag ttg ctg gtt cac ctt gac gat cca gag agg gcc atc 544 Leu Tyr Arg Glu Leu Leu Val His Leu Asp Asp Pro Glu Arg Ala Ile 60 65 70 cag gat gca att tta ggt gag act ccg acg gct tgg cct tcg ttc cga 592 Gln Asp Ala Ile Leu Gly Glu Thr Pro Thr Ala Trp Pro Ser Phe Arg 75 80 85 90 tgc ctg ctt tcg gcg cct gcc acg ggc atc tgt agc tgagccgtgt 638 Cys Leu Leu Ser Ala Pro Ala Thr Gly Ile Cys Ser 95 100 gaccggccac agggccctgg ggcacaggag gggcctcagc tccggcctgg cacactcttg 698 agttcttggc aaaccctgag agcggctgtc tttgtggtga tagctgctga catttcctct 758 aacagaaatc aaaactgaga gtattctaga atacttgtta gttgtttaaa ataacaatag 818 taagcccagt atatattgac acagatggct tgtgtttttg aaaaatactt tccaaaacaa 878 aatcatctgc aagaacgatt tttgcaaatg tcttaaatgt gtagcttgat ggaagacact 938 ggactttcac atcttccata cagtcagtca tgatgtgtat ggctctggct gaaatacgtg 998 gaaaataatc tggcctcgcc tgtggcttca agtgtagttg gacaaaagaa gagtatttta 1058 gtagcctttt cagataggcg tgggacttct tcaataccac gccaacagcg acacaggccg 1118 tcccttgaag gtcactcaca gcacagggcc tgaggccaca caccacagag ccttccacgc 1178 tcagtgcatt aaaatccgct ggtccatctc acacttggaa tgtaacgatt tgcttttttt 1238 tttctttttt ttttttttgt tttgttttgt tgttggtgaa tataatgacg ttgttctttt 1298 ttttaataaa atttgtattt ttaatttttg tgggtacaca taggtgtata taaggcatgt 1358 gtgatactgt gatacaggca tgcagtgtgt gtaaatcaca ttggggaaat ggggtccccg 1418 tcacttcaaa cacttacact ttctttgtgt tacaaataat tcagtgatac ttttcgttat 1478 gtttaaatgt gtgataaatt attgttgacc atagtcaccc tgttgtgcta tcaaatacta 1538 aatcttactc attctgtttt tgtactcatt aaccatcccc atctcttccc ccggccccat 1598 tcctcttccg agcctctggg agccatcctt ctgctctatc tccatgagtt gaattatttt 1658 tatttttagt tcccacaaat gagaatgtgc ggaatttgcc cttctgtgcc tgacttattt 1718 cacttaacat agcgacctcc acttccctcc atgttgatcc aatgactgga tctcatttct 1778 tttgtggccg gataatattc cactgcgtgc gctccacgtt ttccttctcc cttcatctgt 1838 ccgtggacac cccggttgct tccacacctt ggctgtcgga acagtggaac attcggcgtg 1898 cgcgtgcagc tctcccccat agctgaattc ctctcttttg ggtatttgcc cagaagtggg 1958 attgccgggc tgtatggggc tctattttta gttttggagg gacctccaga ctgttctccc 2018 agcggtgctc atttacattc ccaccagcag cgtgagggtt cccttgtctc cacatccgcg 2078 c cgggacttg tttccgcagc cattttaact ggggtcagag gatgtctcac ttgtttctat 2138 gtgcatttct ctgaggagcg gtgctggtgg gcaccttttc agacgcctgt ttgtcatttc 2198 catgctgtct tttgagagct gtctgttcag gtcttttacc catttttaat tggattatta 2258 gattgtctgc tattgagcct gagctcctca tatattccag tgattaatcc ttgtcaggcg 2318 gcggttctaa gatacagtct cccatcccgt acccgcgggc tgtccctgcg gctgtactct 2378 gctcattctt ccctttgctg tgtggaagct ttgggcctgg atgtgctgac tttgcctttt 2438 gcctcctttg gaaaatactt agaccttccc cgcgcagctg cgtccggttt cccggcgtgg 2498 ctacatccgg ttatgcgatg tcggatcttc ctggtgtggc cgcctcccgt cgcgcagcgt 2558 cagaaactcg gatcttcgtg gcgtggccgc ctcccgacac gcggcgtcag aaactcggat 2618 cttcctggcg tggccgcctc ccgtcgcgca gcgtcagaaa ctcggatctt cgtggcgtgg 2678 ccgcctcccg acacgcggcg tcagaaactc ggatcttcct ggcgtggccg cctcccgtcg 2738 cgcggcgtca gaaactcgga tcttcgcggc gtggccacct cccgacacgc ggcatcagaa 2798 actcggatct tcctggcgtg gccgcctccc gtcacgcggc gtcagaaact cggctcttcg 2858 cggcgtggcc gcctcccgtc acgcggcgtc agaaactcgc atcttcccgg cgtggccgcc 2918 tcccgt cacg cggcgtcaga aactcgcatc ttcccggcgt ggccgcctcc cgtcacgcgg 2978 cgtcagaaac tcgcatcttc ctggtgtggc cgcctcccgt cacgcggcgt cagaaactcg 3038 gatcttcccg gcgtggccgc gtcccgtcac gcggcgtcag aaactcgcat cttcctggtg 3098 tggccgcctc ccgtcacgcg gcgtcagaaa ctcggatctt cccggcgtgg ccgcgtcccg 3158 ttacgcagcg tcagaaactc gatattcctg gcgtggccgc ctcccgtcac gcagcgtcag 3218 aaactcgatc ttcctggcgt ggccgcctcc cgtcacgcag cgtcagaaac tcgatcttcc 3278 tggcgtggcc gcctcccgtc acgcagcgtc agaaactcgg tcttcctgcc atggccacct 3338 cccatccggc ggcatcagaa actcggacct tcctggcgtg gccgcgtccc ctcacacagc 3398 gtcagaaact cgatcttcct ggcgtggcca cctcccctcc ggcggcatca gaaactcgga 3458 tcgtcctggg gtggctgctc ttgttacgca acgtcagaaa ctctcctgcg tgggcaccag 3518 gctcagaaga gtccggcttg tggtggcagg gccaagcttt ggctcattgt gattttttgt 3578 gtgagagctt gacttgtatc ctcggccaca aaccctgtcg gttgttctgg gagtgaggga 3638 cttgggccgt tcactttcac gccgtgctct gccagatccc gcgtccgcac agccagggtg 3698 ggtgcactgc tcgtccgtcc gccattcttc ctgggaaaag cagctctgct gcacgaccct 3758 ggtcctccgt g tgaagcggt gcacctggtg cccactcgcg ggtgtaagcc gtgtgcgtga 3818 gggtgagtgt ggcgggtgaa gccgtgtgct cgagggtgag tgtggcaggg ggcgtgggcc 3878 tcagctgctc ccgcatctgc gcaggtgtga gcacagtgac gggcaggccg ggcatgctct 3938 gcctgcgacc acatgcctgg ctttgactca cagaccctct gaagggtcct ggggaccccg 3998 agggccttgg agcccatgtc gggagcccct gccttgagtc gtggaatcag gttgtcagcc 4058 agtgagggag ccccagagtc cattgatcca cggcggggcc cgtggtctct ccaggtcacg 4118 gaaagaagct gcgaattgga gaccaattgg aaattgttta aaaggaggac agcagctcac 4178 gtgcaggcct cgctgggaca gcccatcctg ccagatccac gcaacgcccc cagctcccca 4238 cactccctgg caaatcccag ccctgcctgc gccctcccag ctctcctgtc ctgcactaca 4298 caccatcaac ccgagttctg agcttctcct actctcagcc tcagcctcac tcgtcctcag 4358 gaccttgctc taggccgagg agaccagtgc ccctgtgcac cagctcagcc tgcagccccg 4418 gccctctcgc ctccccagga ctgcacaggg catctccctt ccccactgca cggtacaggc 4478 cattctttct cctgtcttta aaaaaacaaa acacagatgc cctgtacgcc gcccccacct 4538 cccccaccgc acatccgcct ggcagcaggc tccctggaag cagcccgcct tacccctcct 4598 cgaggccctg ggccca tggc aggcatccgc agccgtccac ctgcctgcac ctctgagcag 4658 cgccaggcac agctggcggc cacgcaccct cctctggctg tgggacgccc gtgctcagtc 4718 tcttggtctt tccctcgccc atgtgggccc ctcactgctc ctctgctgtg tctgcaccgc 4778 tccctcagag ctcttctcct ggcctcagct ccacacacaa gtgcagctgc ctggtgccga 4838 accctgggcc gctacccccc tccctgactg cctgccgggt tccgccaccc tcagtggctc 4898 agtggccatc tgtcctcaag actgaaggcg gagaccttga ggtcctcctg gaccccctct 4958 taactcccag cagaatctga tagactcccc agccactgca gcaacctccc catcctcttc 5018 ctgcctcagc tagacacgcc caaccctttc tggcccccac ccctgcagct cccactgccc 5078 ccatcacaca caccaccacg agcccctgac acgtttgcct tcctgatttt catcatcggc 5138 cactgcttcc cgatgaaccc tccgtaagca tgggttcatt tccggctgtg tcggtgatgc 5198 ctggcccgtg ggaggtttgc agtcactgcg gcaggtgaat tggcatccgc aaattggata 5258 agaaagtcgc ctgtttttct gagcctattt gctcctgtga aacctgtttc taagcccaaa 5318 aatgccacct gaagactctg caggacatca tttcatggtc tgcccacaac tgccaggagg 5378 cgattttcag ttctttgaat gcacgttgtg actgccgtgc acccacccag cagcatcagg 5438 ttcctcatat tcacatagtg a ccatgcagc atcaggtcac ttgtccacgt tgtgactcag 5498 gtcattcgta tccacattct gactgccgtc cacccgtcca gagtgtcagc ttacttatat 5558 ccacgttatg actactgtgc acccatccgc tgcatcaggt cgctcgtgtc cagcagtgag 5618 actgtgacag caagaatgta ctcctcagga cacctgcccg ctctttccct ggaataacag 5678 cctctgagtg gattctgcat gttatgtgat ttgttctgtt catcgagagg gctcccaaac 5738 atctgcagct gatttgaaat taaaagtaag tcgcagccgc tcctcccgca gccacttcag 5798 cagcatctta gattttaagc ctcacgtgcg cagctggttc atgaactatt ggctgcatcc 5858 tgcttaggtg cccaccaaga aggtttttac ctacttaaca aaaaagaaag aagccaaagt 5918 gattagaaag aaatgaaatc tctttttggg ttctgtctac tgaaatttaa tatctcagtg 5978 aacagactaa aaggaattta gaatcctaac aacttaccag atttctcctg ttttaaatat 6038 actgggactt taaaggttat atgtccggtc accgtatgtt ttaagtcggt gttaatgcta 6098 acagtgttga aaacaatatt tcatgagatc taattgtggt tgcccctata ggtagcagga 6158 aagtaaagtt gcatttccct ctcgcacatt ctacacccaa gtgcctaaaa gatctcattg 6218 taagtgggta gtgttaccgg aagccattgt gttcacacgg gggaaatgcc gtatatattt 6278 ttcaacaaat attaacgttt atactt tcat gtttgaaaat ttaattaaaa atatttgttt 6338 t 6339 <210> 6 <211> 6374 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4433) .. (5401) <400> 6 ggcagcggca gctggggctg cagcggcgcc gggctctaga gagccgcagg atcggccaga 60 gtgcggagct ggacacccgg gtcccagata ctacagacac ccggagaggt ggctccttcg 120 ccctgaagcc ttcctcggcc ccctacgcac tcgggcccct tccgcagagg attcgcagcg 180 tgagcgcccc gcagcccgct caggaccagc tcacaggact aaggaccaaa ggcatttctg 240 ggcactgaga tcctacctct ctgcctgcag ctatgagcag acgtgtggtt cggcaaagca 300 agttccgcca tgtgtttggg caggcagcaa aggccgacca ggcctacgag gacatccgtg 360 tgtccaaggt cacatgggac agctccttct gtgccgtcaa ccccaaattc ctggccatta 420 ttgtggaggc tggaggcggg ggtgccttca tcgtcctgcc tctggccaag gtgagggatc 480 agggaaagga agcaagtggg aggacactag ctggggcccc tgggaactcc tgagcctttg 540 ttctcaccta gttccattcc atagtcagga gaagcatctg tgtggattgg ctcctcccta 600 ttccccaagc cctcaaggac cagaggggag gccaccccac cccaccctaa catcagggtg 660 gcttactccc actccctagc cctcccacct ctccatgcac caccccattc ccagcaggga 720 ccaggagggg agccgggtga tggagatggt tgggacacag cacagccaag cctggccaga 780 ttccatcact gcctctccta atgccgcatc ccctcatgtt ttgggtgtgg agaacctcct 840 ccctagccca a gatgaccat ttgattaagt cacatcccag agcagcaaac tgaggacagg 900 gtcaggctct atccaaagag tccctggtta cctccaagga cacttgcagt gaagtagaaa 960 gaaagggaac ggaaaggaag ggggacatga cacataaagc cagagccctc cctaccctca 1020 ggatggggac caggcaatga ctaccacgtt agcttcataa ccttaagccc cttgaccatc 1080 cacatcccaa ggatgactct cccccaaccc ccaaggtatg accttgacct ggattctggc 1140 ccctacacct tgttagggta ggctccacag gtggcggggt caggaagagg cctgaaaaag 1200 ccagtgactc accccagaca atgcagacat catcctggga cacagcccca gggctcaaat 1260 ttcagccgga gctgcctcct cccccaatat gtctgctctt tcagtaccac atagccaccc 1320 tctcccccgc tgcctggtct ggaccagtgt ctgcccctgc agaggtctca gaacccccac 1380 aagcagcctg tgaagaccaa aaaatagatg ggcccccagc tcccatttgg ggatagtagg 1440 caccaggact gcttgctgct tgtggttcca aggtaaaagt ggttcacaag gaagagatct 1500 gccaagggag gccaggaaag ggctgtccag cactacacta ttatctcacc ttgacctctt 1560 ccaccaggag attcccacag acacttcaat aggagaacag gctgaagaac agcctcctcc 1620 aagtaggtgt ctttggaaga gcactgggct ggaaagttca aatctcagct ctacaagtat 1680 cttgttgtgt gtccttgat g aggccatctt acctctctgt gtcacagtcc ctaatattaa 1740 attatttcaa ctctgccttc agtaaagtgc aggaagtgga ctggatgggg ttagaagtgc 1800 agagagggat ctgcaaagag aaaataggta ataaggaatc gagatgtaag cagatctgct 1860 acccactccc caaaaaacac acaggagagt agccccacat cttcttctcc aacccctcag 1920 acagggcgag tggataagaa ctacccactg gtcactgggc acactgcccc tgtgctggat 1980 attgactggt gtccacacaa tgacaacgtt atcgccagtg cctcagacga caccaccatc 2040 atggtaggag ccaggtggct actgctgggc agttgagcag gggagcaggg aaggctgcct 2100 cacctgtgct ggggaaggtg ctaagggtgg taataaggga ggtgctgggt cccagggccc 2160 tgccctgccc agctcctgga ctatttttag ctacatgccc accccctccc aggatgcact 2220 gcttaggact aattatagcc atggccaact tggtgcctgg agagcagcag ggcagtgctc 2280 tgaagtctcc ctgctggagt gaatgggagg tctctggaga gctggcagtg ccccctcctg 2340 gctcccagct gcttctgttc taggcatgca ccaccacatc ttgccctgta tttgaccctt 2400 accactcaag agagccagta gggttaaaaa aaaaggtagg gaaggagtgg agggacaggg 2460 tggctcctca ttccacccac catatacctt ttcttcctac ccaggtgtgg cagattccag 2520 actatacccc catgcgcaac att acggaac ctatcatcac acttgagggc cactccaagc 2580 gtgtgggcat cctctcctgg caccctactg ccaggaatgt cctgctcagt gcaggtctgg 2640 gggctaagga ggggtccccc atagatgggt gggtggtggc aaaggtggga cccaggtgac 2700 catgcctggc cactctgggc aggtggtgac aatgtgatca tcatctggaa tgtgggcacc 2760 ggggaggtgc tgctgagcct ggatgatatg cacccagacg tcatccacag tgtgtgctgg 2820 aacagcaacg gtagcctgct agccaccacc tgcaaggaca agaccttgcg catcattgac 2880 cccagaaaag gccaagtggt ggcggtgagt gcctggcctg gccactcccc agaacccctt 2940 gaccagtggc cagctgtcag cacccttgta cccaccatta tcagagcccc tggtcccggc 3000 tttcacctgt cgcatccctg ctccagagac tagccccctt cccccgtctc tgcaaccaca 3060 ggtctctgcc ctaagtaagc ccccagcctg caattctctg cccggctcct gttccctccc 3120 ctcccttgca tctcagaagc tcagagaagg gctcctcgct ttgggattga ggaggggaga 3180 agctggaaac tccatcctcc caccagaacc tgcatgaaac ctgagctcct ggacccctct 3240 cctctcagcc ggcacccaga cgcatcttcc agggtctggg gcctgacact ggctcgaggg 3300 ctggcccttt ctccttgtgg acccgctggg cgggggatgg ggcaaccctc gcgcgttgct 3360 tatcccagcc ggatgccctg ggagggcg gc ggccctggcc tcgccagcct caagtctaac 3420 ctggggtgcg ggtgcgtggg ccgcgtgcat gtctgcgtgg agcaagcgcg ccgagagcgg 3480 tcggggctgg cgccggggcg ctctaaccca ctaacccggc gagcaggagc aagcccggcc 3540 tcacgagggc gcccgcccgc tgcgggctgt cttcaccgca gacgggaagc tgctcagcac 3600 cggcttcagc aggatgagtg agcggcaact cgcgctctgg gacccggtag gccaggccgc 3660 gccgggcgcg ctagctcgct ccttctctgg gtctgccggg agcgccttcc cgggctgtgg 3720 ctggcgccca agaggccaga gcggagcggg gagctcccat tcgggaaaag cctcgctgcg 3780 actccgggga gccagcagac acccctgctc tagggatcgg cctttgagcg cgcttaaggg 3840 ttcgggatcg gctgagagcc gcgtgcctcc tgctctctcc aggcccggat gctctccagg 3900 tcaggggcca gacgtggccc cgcaggaagc tgagtgctta ggccccattt gtctcttccc 3960 cgcatccgct cctccacccc ggacacccaa gtcagcaagc tggttgctca tccctccatg 4020 ctcctcaggg caggcagctg ggtgatgtcc ctccctgtct ccccctcccc ccaggagagg 4080 tttgcggccc acgaggggat gaggcccatg cgggccgtct tcacgcgcca gggccatatc 4140 ttcaccacgg gcttcacccg catgagccag cgagagctgg gcctgtggga cccggtaacg 4200 cagctggagg cttggggtgt gtgcctcggg gac tggcatc acgggagagt ggccaggcgc 4260 cccccacccg cagggcatgc ccacctggac aggactgaag gctgctgcca cctctgcagc 4320 gcctgccatt ctcacaccca cccctctgcc cagttttgct gcgtcgcgtg aaggatcctg 4380 cgctggcgcc cccacctggt gatgccgagt ccctgggggt ggtttgctgt ga ctg cat 4438 Leu His 1 gcg gcg cgc agc ggg tat atg tgc agg gga gga gga gct atg tgc gca 4486 Ala Ala Arg Ser Gly Tyr Met Cys Arg Gly Gly Gly Ala Met Cys Ala 5 10 15 ggg gag gag gag aga tgt gcc cag ggg agg ggc ctg caa ctc tgg tca 4534 Gly Glu Glu Glu Glu Arg Cys Ala Gln Gly Arg Gly Leu Gln Leu Trp Ser 20 25 30 cta gag gtt tgg ggc ata ggg ttt ggg aag gcc agg aag cgt aaa ggg 4582 Leu Glu Val Trp Gly Ile Gly Phe Gly Lys Ala Arg Lys Arg Lys Gly 35 40 45 50 gct tct ggg ggt ccc gaa gta gca cgg gag ggt ggg gca ggg ctg gtc 4630 Ala Ser Gly Gly Pro Glu Val Ala Arg Glu Gly Gly Ala Gly Leu Val 55 60 65 acg cct cct gtg ctc ggg cag aac aac ttc gag gag cca gtg gca ctg 4678 Thr Pro Pro Val Leu Gly Gln Asn Asn Phe Glu Glu Pro Val Ala Leu 70 75 80 cag gag atg gac aca agc aac g gg gtc cta ttg ccc ttt tac gat ccc 4726 Gln Glu Met Asp Thr Ser Asn Gly Val Leu Leu Pro Phe Tyr Asp Pro 85 90 95 gac tcc agc atc gtc tac ctg tgt ggc aag gtg ctc acg gcc ggg cag 4774 Asp Ser Serle Val Tyr Leu Cys Gly Lys Val Leu Thr Ala Gly Gln 100 105 110 gga gaa cag ggc act gga tgg aga tgt gga ggg cct tgt ccg ggc gcg 4822 Gly Glu Gln Gly Thr Gly Trp Arg Cys Gly Gly Pro Cys Pro Gly Ala 115 120 125 130 ccc ctg aac cga ctg att ttg cag ggc gac agc agc att cgg tac ttt 4870 Pro Leu Asn Arg Leu Ile Leu Gln Gly Asp Ser Ser Ile Arg Tyr Phe 135 140 145 gag att acc gac gag ccg cct ttc gtg cac aac acg ttc agc 4918 Glu Ile Thr Asp Glu Pro Pro Phe Val His Tyr Leu Asn Thr Phe Ser 150 155 160 agc aaa gag ccg cag cgg ggc atg ggt ttc atg ccc aaa agg gga ctg 4966 Ser Lys Glu Pro Gln Arg Gly Met Gly Phe Met Pro Lys Arg Gly Leu 165 170 175 gat gtc agc aag tgt gag atc gcc cgg ttc tac aag cta cac gaa aga 5014 Asp Val Ser Lys Cys Glu Ile Ala Arg Phe Tyr Lys Leu His Glu Arg 180 185 190 aag tgt gac ct atc atc atg act gtg ccc cgc aag tca gac ctc ttc 5062 Lys Cys Glu Pro Ile Ile Met Thr Val Pro Arg Lys Ser Asp Leu Phe 195 200 205 210 cag gac gat ctg tac ccg gat acg cca ggc ccg gag ccg gcc cta 5110 Gln Asp Asp Leu Tyr Pro Asp Thr Pro Gly Pro Glu Pro Ala Leu Glu 215 220 225 gcg gac gaa tgg cta tcc ggc cag gac gcc gaa ccc gtg ctc att tcg 5158 Ala Asp Glu Trp Leu Ser Gly Gln Asp Ala Glu Val Leu Ile Ser 230 235 240 ctg agg gac ggc tat gtg ccc ccc aag cac cgc gag ctc cgg gtc acg 5206 Leu Arg Asp Gly Tyr Val Pro Pro Lys His Arg Glu Leu Arg Val Thr 245 250 255 aag cgc aac atc ccg gac gtg cg ccg ccc tcc ggc ccc cgc cgc agc 5254 Lys Arg Asn Ile Pro Asp Val Arg Pro Pro Ser Gly Pro Arg Arg Ser 260 265 270 cag tcg gcc agc gac gcc ccc ttg tcg cag cac acc ctg gag acg ctg 5302 Gln Ser Ala Ala Pro Leu Ser Gln His Thr Leu Glu Thr Leu 275 280 285 290 ctg gaa gag atc aag gcc ctc cgc gag cgg gtg cag gcc cag gag cag 5350 Leu Glu Glu Ile Lys Ala Leu Arg Glu Arg Val Gln Ala Gln Glu Gln 29 5 300 305 cgc atc acg gct ctg gag aac atg ctg tgc gag ctg gtg gac ggc acg 5398 Arg Ile Thr Ala Leu Glu Asn Met Leu Cys Glu Leu Val Asp Gly Thr 310 315 320 gac tagccccgcg cgccaggcag gcggagcggg gcggggcgca caagctcggc 5451 Asp cccgccccgg cttttagtcc cgaactccgg accccgcctt cttgggctgg gcccgggggc 5511 gggactgggg agggaactcc gcccctcgcg ggagaccaga actcttggag cttaggggag 5571 acccacgtcg ctccagcgga ggctggactg cgagcctcgt ctgggactcg gctggagctg 5631 gcctagggag gcctggggta acctgggggg ctcagcaatg gtgctgcacg gcgaggtggt 5691 gtcccccttt gtcctccgcc cagggcaggg aaagtgctta gtattagcgt gatgcttggg 5751 gttattggag cctgagcttg acctcaaacg ggtggcgatt tgatgggtac ccccaggctg 5811 gggaaaatga cagcgcttct cctaatcagc tcactggatt ccatcaccct gagcggtaaa 5871 ccagatgggc gtcaccccag ttctgcagac acatacacaa cccgtttgct gcagagccgg 5931 acccagtggc tacacccaca gcggtctgtg gtagagaact ctcttccttc tttccaccga 5991 caggggcgag ggctgcttcc tcgcggcagc ccccgcgaag aaatctcgag agaactccag ctagcgac cctgcc cctgcc cctgcc cctgcctg 111 tctcagaaaa acaagacgta ctgaatgaaa tattttacta agcgttcagt ctgtgcctcc 6171 tgcatgggtg ggagtgaggg gaacgagacc cccagcctct gcaaatgcta cccccaggct 6231 cctgggagac ctggcgatgc actcctgggc tcagggtcca tcaggcagcc tcttacccta 6291 gagctctctc cactctgagg ttcagaagga ccccaaccca caccgtaggc gttcccccca 6351 agtaaagtta ggtagcaaaa gcc 6374 <210> 7 <211> 5877 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (943) <400> 7 c ttt gcc tat agg tca gcc ttt att gtt cat aag aag aag cat gcc atg 49 Phe Ala Tyr Arg Ser Ala Phe Ile Val His Lys Lys Lys His Ala Met 1 5 10 15 aaa aga aaa cct gag ggc ggg cca tct ttt agt cag gac aca gtg ttc 97 Lys Arg Lys Pro Glu Gly Gly Pro Ser Phe Ser Gln Asp Thr Val Phe 20 25 30 cag gtt cct cag agc agt cac tcc aaa gag gag ccc tac aaa tgc agc 145 Gln Val Pro Gln Ser Ser His Ser Lys Glu Glu Pro Tyr Lys Cys Ser 35 40 45 cag tgt ggc aag gcc ttc cgc aat cac tca ttc ctc ctc atc cat cag 193 Gln Cys Gly Lys Ala Phe Arg Asn His Ser Phe Leu Leu Ile His Gln 50 55 60 aga gtt cac act gga gag aag cca tat aag tgc agg gag tgt ggg aaa 241 Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Arg Glu Cys Gly Lys 65 70 75 80 gcc ttc aga tgg agt tcc aat ctc tac cga cat cag agg att cac tct 289 Ala Phe Arg Trp Ser Ser Asn Leu Tyr Arg His Gln Arg Ile His Ser 85 90 95 ctt caa aaa cag tat gat tgc cat gaa agt gaa aag act cca aat gtg 337 Leu Gln Lys Gln Tyr Asp Cys His Glu Ser Glu Lys Thr Pro Asn Val 100 105 11 0 gag cca aaa atc ctc act ggt gag aaa cgt ttt tgg tgt caa gaa tgt 385 Glu Pro Lys Ile Leu Thr Gly Glu Lys Arg Phe Trp Cys Gln Glu Cys 115 120 125 ggg aaa acc ttt aca cgt aaa aga acc ctt tta gat cat aag gga ata 433 Gly Lys Thr Phe Thr Arg Lys Arg Thr Leu Leu Asp His Lys Gly Ile 130 135 140 cac agt gga gag aag cgc tat aaa tgt aat cta tgt ggg aaa tct tat 481 His Ser Gly Glu Lys Arg Tyr Lys Cys Asn Leu Cys Gly Lys Ser Tyr 145 150 155 160 gat aga aac tat cgc ctt gtt aac cat cag agg atc cac tct aca gag 529 Asp Arg Asn Tyr Arg Leu Val Asn His Gln Arg Ile His Ser Thr Glu 165 170 175 aga cct ttc aaa tgt cag tgg tgt ggg aaa gag ttc att ggg aga cat 577 Arg Pro Phe Lys Cys Gln Trp Cys Gly Lys Glu Phe Ile Gly Arg His 180 185 190 acc ctt tcc agt cac cag agg aaa cac acc aga gca gca cag gct gaa 625 Thr Leu Ser Ser His Gln Arg Lys His Thr Arg Ala Ala Gln Ala Glu 195 200 205 cgt agc ccg cct gca cgg tct tcc tct cag gac aca aag ttg aga tta 673 Arg Ser Pro Pro Ala Arg Ser Ser Ser Gln Asp Thr Lys Leu Arg L eu 210 215 220 cag aag cta aaa cca agt gaa gag atg ccc ctc gaa gac tgc aaa gaa 721 Gln Lys Leu Lys Pro Ser Glu Glu Met Pro Leu Glu Asp Cys Lys Glu 225 230 235 240 gct tgc agc cag agc tcc agg gga ctc cag gac ata agc att 769 Ala Cys Ser Gln Ser Ser Arg Leu Thr Gly Leu Gln Asp Ile Ser Ile 245 250 255 ggg aaa aag tgc cac aaa tgc agc ata tgt ggg aaa act ttt aac aag 817 Gly Lys Lys Cys Hiss Lys Cys Ser Ile Cys Gly Lys Thr Phe Asn Lys 260 265 270 agt tca caa ctc att agc cac aag aga ttt cat act cga gag agg ccc 865 Ser Ser Gln Leu Ile Ser His Lys Arg Phe His Thr Arg Glu Arg Pro 275 280 285 285 ttc aaa tgc agc aag tgt gga aag acc ttc agg tgg tct tcg aac ctg 913 Phe Lys Cys Ser Lys Cys Gly Lys Thr Phe Arg Trp Ser Ser Asn Leu 290 295 300 gct cgg cat atg aaa aac cat att aga gat tagcctggga cctgacag His Met Lys Asn His Ile Arg Asp 305 310 acagtgggtgggttctca gtcccctgct agagaaccct taattatagg cattgtggag 1023 taactttgat aaagggccca gccctttctg ttttggaagc tagtgacaga atcccaagga 1083 tttga aagct cggggagtcc ccagcctgcc tgctaggatg tgacgctggg gaagtgcagc 1143 accatgtcct ttggagccct tctggagact ccggccccta ggagtggcct ctgcaccata 1203 gcctgcggct cccctattca ggtctccttc cacaactctg aagagagaga ccactgccct 1263 ttgtggttgg acagaatatc tgtggcatca tgggctatgg ctgctggaaa ggggccagtg 1323 ggatcctaga tttgtcttca agtttggcct gtggccatgc ctattctgtt gactttaaaa 1383 gcagcagcat caagaactcc tagccttccc aaatgccccc tggggagttc tggctggggc 1443 ttcagccttc ctggctggct tttggatatc tgctaggggg ttagagtggt ctcagcggca 1503 ggtggaggag agcaggatgc tgggctcaag cgcttggcgt gtggatctct accagtaccc 1563 tgttgccatc cccatcccac aggcctgcat aggcagcagc ggtccatctg tttaacagaa 1623 atgtgctgag cactcccata caccaggcgc tggtgtgttt gccagagacc cagcagggac 1683 cagaacagat gaaaatcctg ccatcttgga tctttacaga tgacaaacaa atgggatacg 1743 cagtattctg gatggtgatg tgtgtagtgg acaaagtgaa tcagagaaga gcagagggag 1803 tgctggattg ggagatcagt cgtgatttta gatagtctgg tcagggaggg cctcaactga 1863 gaaggtgaaa tgtgagcaaa gacgtgaagg aagccaggga ggtagcaggt agctctctag 1923 ggagagttgc aggcagagga gattgggtct tgactggtgt cctcaggaag gaagcccctg 1983 ggatggagtg cagggagcca gctggaaggg aaggagaggg gccagggagg ccacaggccc 2043 ggccatatga gcatcatggg tcattacggg ggcttgagct ggctcagagg gaggcaggga 2103 gcttttggac aattttgagt tgaggagtga tgtggtttga atctgaatta tattttataa 2163 gggttaacca cagatccaag gactcagtaa aagggtgaaa ggcttctcat gcagttagcc 2223 ttgctgccag ttcccataaa tcagactcct ccccactccg tttctgaatt ttctatagga 2283 tcctcggcct cagcagatat aaacgcttac cattgttgtg ttcatgtctc tagcccctgc 2343 acactgcagg cccctctcag cttcacatac ccctctccat gtatgagatc tggtgctagc 2403 aatcagattc aacccgaagg aacaagtgca tgtgcctgct gctctcagga gaaaaggcag 2463 cctgttctgg gaggagctcc ctcactggcc cacccacttg tgttgaagca aaaagcaaga 2523 atcaattact taaaggcaaa ggagtgatat tgctaaagca tgtgagtaat cattgcttct 2583 gattattgaa gaggtcagat tatgaatgaa aggataaaat gttttaatag tagagcagtg 2643 tcctgactat aggggcccgt tcatggagct ggtcatttct tgaaatgaga agaaaccaac 2703 ctggaagatg tctttttcag tagagtatgg aataatctta cctgctctgg attgccatga 2763 gcaggtgaaa atga aggctc tgatattgtg tggtggtgtc acaggatggt gggggcgggg 2823 cagaagtctc ctgttggtgt tctgatgcct gttcagcttt gtcctcagga aggtttggtc 2883 atcttggttc tgccatcctc ttgccttcct acggcagcag ctgttcatgg cactgaagat 2943 gtcccttcac tgtcccaaaa ctggcactag aagtggctgg gcaggggggc cagagtcata 3003 ggaagggtct tggagtcatc agatctgggt tccaggcatg gtgtgccttt tcttggcagg 3063 attgatcttg agcaagtcaa tgaacctctg catcagtttc cttatgtgtg aagttagagt 3123 gcttggctgt gctacctgat tcctgagatt ggtgaaagag ggcttggttt accaaggctc 3183 tccatcaagt ggttgacctc taggaccagg gccctctcag aggtgcagct tccatgtcag 3243 ttggtgttgt aaccatggaa aagtcccttt ccaatcaaac ttttagcacc cctttccccc 3303 catctctgct ccctttgcca caggatacct tgtaaagttc ctgccccagt atagggatat 3363 ttttactgtc ttttttattt tttgagacag ggttgcccag ggtggagtgc agtggcagga 3423 tcacagctta ctgcagcctt gacctcccag gctcaggtcc catctgagcc tcccgagtag 3483 ctggggctac aggtgtgtgc caccctgcca gctaattttt tatatttttt tgtagagaca 3543 aaacttttat tttttttttc ccatgttgct catgctggtc tcaaactcct gggctcaagc 3603 aatccaccca cctctgcctc ccaaagtgct gggattacag gcgtgagcca ctgtgcctga 3663 cctgtcattt ttatagaatg aaatgtgctt atttctaaac attctaatca aattttaaaa 3723 tgtgcaaaga atgaagtgaa aaactgaatt tttttttttt tttgatacgg agtctcactc 3783 tgtcacccag gctagagtgc agtggcgcga tctccgctca ctgcaagctc tgcctcctgg 3843 gctcacacca ttctcctgcc tcagcctcct cagtagctgg gactacaagt gcctgccacc 3903 acgcctgggt tattttttat atttttagta gagacggggt ttcactgtgt tagccaggat 3963 ggtctcgatc tccaggatgg tctcgatctc caggatggtc tcgatctcct gacgtcgtga 4023 tccacccgcc tcggcctccc aaaatgctgg gattacaggt gtgagccact gtgcccggcc 4083 aaaagaacag aaattatttt atcctgaagt aagctgttta tatttgggat tatactgaac 4143 ctatttgtcc aataacctga gttttcaaat aattttagtt ctataagtac tataattata 4203 taaatattaa tgaattcaga ttagctgaaa ggaaaaaaag tagaagcctg actacttggt 4263 gctaactact aaagattttg gcagaatcaa tgttggattt ggctttcctg tcccttcccc 4323 atgccagccc cccagagtgt tctgccttgt gctgcctccc ttcacctgga gtgccacacc 4383 cctctctctg ccagttcagc tcttcattct tcaaggcctg accttgtctg acccttgtgc 4443 ctctaaaccc gtggccccac ctct cttggt tcctatgtca ggtgatgttt gtgtttttgg 4503 ttatgcccat ctccatagcc agaccaagca ctctggaagc cagggttggg tgcttattta 4563 tctgtttgcc atgcagaaaa tatcttgcac aaaattacct ctgttaagga atctgaagct 4623 gaatttagtt tggctgagtc agggttgggt tttttttaag gggctgtggg gtgaaatgtt 4683 gactggaagc cacccacaaa cacacacctg ctggttagga acccggctgt gggtggttct 4743 gagctgtttg gcttcagttg acagtttctg attgccctga gcaccaggtc tcatcttgca 4803 tctcatcctg gcctggagaa cattcagttt ccttccaacc cttcccacct ttcccccact 4863 cccttggagg aactgaagtt ggggttgagg agagccagat ggctggagtg ggtatttgaa 4923 ggtctttctg tcacctgttc agtgtggtct gccccacccc tgctgaccaa gactgactga 4983 aatgtaaaat aatacagacc atctcacact cagaaagctg gcacattttt gaaagcccaa 5043 gtgtgggtaa gtgcgtggaa caacgataat tcacactgct ttatgagtag aaattgtgag 5103 aaatattgtg ccaggcaatt tgcaaaatct tggaaggttg tgtgcactta accacccagc 5163 aactactcct ggatgcatcc tagagaagtg ccatgtgaac agagaatgat tttaagactt 5223 cactgaagta ttgtttaggt agcaagattg ggaaaagcct gcatttcatc agcagaagaa 5283 tggataaata aatgggttgt ttttggtcct tggaaagtga atatgaaaga gttacgtctc 5343 aacacagata gatgaaaaat tatgctgaga aagttggtga agctacatac aaggtaccct 5403 tagtgtaaag ttaagcatac tgtgtacctg tgggcacgtt acttcaactt gtttttcact 5463 ttttctgtaa aatgggatag tagtggcaat ctcacagggt gattgtgggt gggggggtgg 5523 tcaatgaagt aatgcatgta aaatgcttag aatagtgtct agcatgtaag ccttgtggac 5583 atatagaaag tgttattgtt ttgcacagta atctattttc tgtggattca aataatatga 5643 aatgagtata aaatcatgta ttggaacgat gtgtgcaagt caccattctg ccttcctaag 5703 gcaggagacc tgatggattt ggggagggta catggggcct tcagttgtgt tttctttgtt 5763 tttttctaaa aattgatgca gaggcatcac aatgttaaga ttttaacagg gtagtgtggt 5823 gggtactttt taactgtttg cttaaagtgt ttcaaagtaa aaatatttct taag 5877 <210> 8 <211> 6180 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (562) <400> 8 c acc gtt ctg ggt gtt cct cag att agt gga ttc tca tca 49 Thr Val Leu Gly Val Pro Glu Lys Pro Gln Ile Ser Gly Phe Ser Ser 1 5 10 15 cca gtt atg gag ggt gac ttg atg cag ctg act tgc aaa aca tct ggt 97 Pro Val Met Glu Gly Asp Leu Met Gln Leu Thr Cys Lys Thr Ser Gly 20 25 30 agt aaa cct gca gct gat ata aga tgg ttc aaa aat gac aaa gag att 145 Ser Lys Pro Ala Ala Asp Ile Arg Trp Phe Lys Asn Asp Lys Glu Ile 35 40 45 aaa gat gta aaa tat tta aaa gaa gag gat gca aat cgc aag aca ttc 193 Lys Asp Val Lys Tyr Leu Lys Glu Glu Asp Ala Asn Arg Lys Thr Phe 50 55 60 act gtc agc agc aca ctg gac ttc cga gtg gac cgg agt gat gat gga 241 Thr Val Ser Ser Thr Leu Asp Phe Arg Val Asp Arg Ser Asp Asp Gly 65 70 75 80 gtg gcg gtc atc tgc aga gta gat cac gaa tcc ct gcc acc cct 289 Val Ala Val Ile Cys Arg Val Asp His Glu Ser Leu Asn Ala Thr Pro 85 90 95 cag gta gcc atg cag gtg cta gaa ata cac tat cct aat gct ttg gct 337 Gln Val Ala Met Gln Val Leu Glu Ile His Tyr Pro Asn Ala Leu Ala 100 105 11 0 ggc cag aat ggc cct gac cat gct ctc ata gga gga ata gtg gct gta 385 Gly Gln Asn Gly Pro Asp His Ala Leu Ile Gly Gly Ile Val Ala Val 115 120 125 gtt gta ttt gtc acg ctg tgt tct atc ttt ctg ctt g cga tat ctg 433 Val Val Phe Val Thr Leu Cys Ser Ile Phe Leu Leu Gly Arg Tyr Leu 130 135 140 gca agg cat aaa gga acg tat tta aca aat gaa gct aaa gga gct gaa 481 Ala Arg His Lys Gly Thr Tyr Leu Thr Asn Glu Ala Lys Gly Ala Glu 145 150 155 160 gat gca cca gat gct gat aca gcc att atc aat gct gaa ggc agc caa 529 Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Ser Gln 165 170 175 gtc aat gct ga gag aaa aaa gag tat ttc att taagatgcag gccaagattc 582 Val Asn Ala Glu Glu Lys Lys Glu Tyr Phe Ile 180 185 tgagttttac taccaggctg aatgctggag aaaactggct atcatctttc agaagtcatt 642 tctaccatcg tctgctaccc ttattaactc ccatactgta ctgctatcag tagccagtgt 702 ataccaacaa tcagctgttg aaagcatcat tctttaatta ctgtaccatc cataatgcag 762 ggcatttctt actgcctaaa tttcacacca ttgctctttt aacatacagt gcttgaatat 822 acagccttaa caat gttaat catctccttg gatcattata ttgagtggtt tttatacatt 882 aaaaaatgta tgcagagttt ttttccccca ttttttcccc tttaagtcat agaccttatc 942 agtttgccat tggacagctt tcacaagtaa caggattagg gaaggacata atgtatttaa 1002 gaataagtga aggttagagg tttacaatta atgttttcta catgtctgtc ttcaaagaca 1062 acatgctttg gaaacatatg tcctagaaaa cataaaatta aaaaaaaaca ctatagtgta 1122 gtttttggaa tgttggagat tatactggta aagctgtatc gatttgctat tgaaatatag 1182 tatttgatac aggagccatg tgtacgaatt gcaatcatga catggtattt tctataatta 1242 tagagatctt actattagga tattgtagct tcatttacca ataaattatt ccaaatgatt 1302 tactgctttt ggaatcacaa atatttaatt catttctcta atttgattct ataatttatt 1362 tgcttcataa agattcacct gcctaaacaa tattgaagta tccatagggc acaattttca 1422 gacattttag tatctgtata tagtgcatat aataaatcca attaaacatt atttgataca 1482 tatttaactt ttttggctgt atgtaattca gtcataagta agcattttct aacgtccatt 1542 atatcccttt aggtattact taaaccaata ttataagtag ataacatgta ttagtatttt 1602 tgtctgtatg tcctagcact gttcaacaac aaatttttct agttcttgtt aatttttatt 1662 tgttatacaa tggaagcaca atgttataag gaaaggtaat tttaagctaa caaccagtgc 1722 acagcctcag gttttaaatt acaaccacag ttgaataata acctaaaaat aaattttagt 1782 ttgctaaaaa tttacaaatt ttcattttgc agttccagag ctgcttacct atgttggttt 1842 gccaaaaaga agtgtttaag atatgttttc tgtataaatg aactaattct ttatattaaa 1902 ttcctgtcta tgcattttgt gaggtacaaa ctgatgaaac agtgagtgat agagaatttc 1962 tgccatgctt ttaactccaa agtgaaagtc tctttctctg gattatttta aaattttggc 2022 gtgtttaacc attaagaaat gctgtattct taaatatgaa acagttaatc taaagtctta 2082 ttatttcttc tagtaaaata aaatattgtt agattagttc tcattaaatt tattatatgc 2142 taaagaataa aactccagtt agatttaaaa aaatcccatt tacaagcatt gcacctttaa 2202 gaagaaaaca aatatgacag tatggtagct atacttgtga tgtctgacgc atgatggcct 2262 atggttttaa aaatagtatt gtggaatata tttttgggta ataagaatgg ttgagtgcaa 2322 catcatgtat taatatcaaa tgaaagacaa gggtgctgta tctttgatta tttatcaaaa 2382 aagtataaat cttttaagga aaatgttaga attttaaagt ttttttttga ttgttgaagc 2442 atttatcttg ttgatttctt acaaaagaaa aaggacgatg tcagtcaagc agcacttttt 2502 cagaatatac agaacataaa taatat gatg tggttgagtg ttaacataat aaatcatata 2562 cagtatgaca ttttaaggaa ataagtctgc attgatgtga ttgcatgctt gtttttacag 2622 ttcactccat accatctgtg gaaaaatgca ataatatgtt aatatagtat ggtagtttga 2682 gagaatcagg taggtgctac tagacacatt gaaactagaa taggtttata aactgttcat 2742 atctttcaat gcataatctt tagaaagact ccacaaagca aaattcatcc tgttagtaca 2802 aaatggaaag gttcttatta cagaagtaag ttgtacaaac tgcatcatca attactatgt 2862 aaagcctaat ttcaggatgc acttacaaaa ttgctactct tcatcgatgc cgtatttaca 2922 tccctcttca tttcatctat attctacttg gctccaacaa ctaaattgtt gcctaaataa 2982 ctcaatcatt atttatagca ctgtaaaatt agaaatccaa aattggttgc atttcatgat 3042 ttttgactct tttaaccctt cagagtaata taaaatctca ttagaactct tataaaacca 3102 gttagctaaa acaactagat tattatacta gttataaatg ctggtatatt ataatttgtg 3162 ggatctaatt aaatgtttgc ctattaaata tagtttgatt taaatgagac accatgttct 3222 gaactggaga aaacaatatc aatgaagtca tattttcata cctttaaaaa ttatttaatt 3282 ttcaaccaaa caaaaaataa attgtaaaaa ttatgctcat ttctattcca acaagtcaga 3342 aaataatgac ataatatttc taaatgagaa tgatgtcaat ttcattgtct ggaacatgca 3402 cacttgtgtg cacatagagt caatttctgt ctcttctaag tgagcacagt aggtagggaa 3462 ctcaatggaa gcagtgtgca cacacacaca cccttagtag aatatggagc attattcttt 3522 accaaaagta gctattctct gccagtgtac tgtttacagt gtaaattgat tgtcctccgt 3582 caaaatcaag tctaagcggc attttacttt tcttttcttt tttattttcc atttttgggt 3642 gttctagata ggattattat caaaagtagg aggaaaaaga aatgtttgtg agtgcaagat 3702 taaagacaga gcgcatgagc agagtactga tggtgtgcgt gtttgtgtgt gtgtatatgt 3762 gtgtgtataa gagagaaaga gaaatcgaaa agagagagaa atttcaactt gttttctttt 3822 accagagaat ccaagaagca gtttaaggaa cctgatattg gagtttaatc tagaaactgg 3882 atgatctcat attgattcat gatgcttaat ctttcattga aactccacaa ttaaaataac 3942 aaatagagaa agaaaactaa ctttcctaaa tatggcaaag aaactaacac ctcatttatt 4002 tttatttctt tgtaaaaata taaatatctc aatcaaaagt acaggctcat ttgtaattat 4062 gtactcatga ttgtaacagc attgagattt catataggca catgtatagc agctgtttga 4122 cagtgatggc tcttccatgt aacatagcag ttatcgtgta atttagtgcc acttattgca 4182 aagtgttacc aaggggaaca tttcaaatgc cttttg tttt tctttggaca tcaaggtaat 4242 ttagtggaca acaaatatta aattttacat tatgcttttt aattgtggag aaaatgcaaa 4302 acctcatgtc ttaccacaac tttcccatgg tattgctaat tacttagagt ctctaaaatt 4362 gcccaatatt atttcccttt gcaaatggta atttctgata aaacaataca aaacaaaaaa 4422 aaagcagtaa tcacagccaa ataaatgaaa cacctaatga gaattactgt tgagtaatgc 4482 tttttattaa gtggcacaaa gtacacacta aaaactatgc aaaatatagg taactacagt 4542 gtacgtacat gtaagtatct tgtacttgct gtgtatggat gttggaaacc catgtaatta 4602 taatatgcat tttgaatatt gggaaagagg aaatcttagt gtagataata gaatttgttt 4662 tgaaatatac actggcaata ttgaaatata ctcagtgcaa tatctgcagt tctattgctg 4722 gatacttaat gcaaagggat tttaaagaat tcttcagcaa gatccaagag gttgctaatc 4782 ttcacctctc acatactaaa gcattcatta aaaatacaac taattcaagg acaagttaag 4842 tttttcttat taatgtgaca cagtaacatt tttatttgga ttagtttttg gtgttattgc 4902 agagaaagaa ataacctgag ttttaaattt cgattcatat ctcattgaat tgggaattct 4962 tcaattttgt ttgaaatgtg tgcatgtttt catagattgt agcaagtaca aatgtattca 5022 atgaaagaac atagggtagt tttaatagtt aaagtcacta tatcttaatg ggaattttaa 5082 aatatctttt ctttttctat tcattttttc cctttctctc tctattctac ccccaaacaa 5142 gccctttgca ctcataccct tccaaaggca atggattgaa agtagcaaga taataaagag 5202 agttaaaggg gacaacatat aacaatgggt tctaaaatca tcagcatttt tatgtattga 5262 gattattaat attgaatgca atagttattg gatatagctg gtaagttctc tgccatgcat 5322 acttacaata atccttctac ctctcacttt taacatgggc tatgatactt caatataaat 5382 agaggaaata attatttacc agatatccca ggaagcattc ttatggaact attataacag 5442 tgcactcccc accccctggg aaatctcaaa agccaagttc ttcagtgtat tctatggtgt 5502 atgaatctgc atttgttttt ccttttctat cattagcttt tcctaaaggc aaaatattat 5562 aactttataa gaatagtcct tctcctgcct atttaatatt tcaatgttaa tataattgta 5622 ttggttttta aaaataatta aaatggcaac actttgcgat ccaatctgat atttaatttt 5682 taaaatgtaa caatttctta taaattcatg ctgtgtttta agtaaaaatc atgtatatga 5742 attattttac caagtagtat tatctgcacg agacaaattt aagtatttta aaaatcatcc 5802 ttattaataa ataatcctca tataatgcac agtattgcca caaatgccca cttcattttg 5862 tctgcataga catattaaga atttttcaat gatgtaattt aattat ccta aaagaaatga 5922 cagattcttc tgtaggaaaa aataaaaaca tgaatatctc aaattataat ggttaatctc 5982 taaaatatgc ttaaagtaag atgtttctat gttatgtggt tatgttatca ataatatttg 6042 gttgatcttc acatatttta tatgcatata tatatcaaga agttatatat atataactca 6102 agaaactcaa gttatatata tatgtcaaga aatgtatgat tattttggag agaatgggcc 6162 caaatgtgaa aaagatat 6180 <210> 9 <211> 5477 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1766) .. (4774) <400> 9 cggaacggcg gcgcttcgct gcccgggagc gccagctgcg tgaggaggcc gagcgggagc 60 ggcggcagct ggctgaccgt ctgcgctcca agtgggaggc acagcgcagc cgggagttgc 120 ggcagctgca agaggagatg cagcgggaac gcgaggccga gatccggcag ctgctgcgct 180 ggaaggaggc cgagcagcgg cagctgcagc agctgctgca ccgggagcgc gatggcgtgg 240 tgcgccaagc ccgggagctg cagcgccagc tggccgagga gctggtgaac cgcggccact 300 gtagccgccc gggggcgtcc gaggtttccg cggcgcagtg ccgctgtcgc ctgcaggaag 360 tgttggcgca gcttcgctgg cagactgacg gcgagcaggc ggcgcgcatc cgctatctgc 420 aggcggcgct ggaggtggag cgccagctct tcctcaagta catcctggcg cacttccgcg 480 ggcacccggc tttgtcggga tcaccggacc cccaagctgt gcattccttg gaagaaccgc 540 tgccccagac ctccagcggc tcttgccacg cccccaaacc cgcctgccaa ctcggatctc 600 tagacagcct gagtgctgaa gtcggtgtgc gctcccgctc gctaggcctg gtgtcctctg 660 cgtgctccag ctccccagac ggcctgctct ccacgcacgc cagctccctt gattgcttcg 720 cacctgcgtg ttcccgctcg cttgacagca cccggagcct ccccaaggcc tccaaatccg 780 aggagcggcc ctcctcacca gacacctcca cccctggctc ccggaggctc tcgccgccac 840 catcgccact cc cgccgcca ccaccaccgt cagcccacag gaaactcagc aacccgcggg 900 gaggagaagg ctctgagagc cagccctgcg aagtcctgac tccctcaccc ccgggcctgg 960 gccaccacga gctgataaag ctgaactggc tgctggccaa ggcgttgtgg gtgctggcgc 1020 gccgctgtta taccctgcaa gaggagaaca agcagctgcg gcgtgcaggc tgcccctacc 1080 aggcagacga gaaggtgaag cggctcaagg taaagcgcgc ggagctgacc gggctcgcgc 1140 ggcgcctagc tgaccgcgcc cgcgagctgc aggagaccaa cctccgggcc gtgagcgcgc 1200 ctatacccgg cgagagttgc gccggcctgg agctgtgcca agtctttgcc cgccagcgcg 1260 ctcgggacct gtcggagcag gcgagcgcgc cgctggccaa ggacaagcag atcgaagagc 1320 tgcggcagga gtgccacctc ctgcaggcgc gtgtcgcctc gggtccctgc agcgacctgc 1380 atactggaag gggcggcccc tgcacccagt ggctcaacgt cagagactta gaccgcctgc 1440 agcgcgagtc ccagcgggaa gtgctgcgcc tgcagaggca gttgatgctt cagcagggca 1500 acggtggcgc ttggcccgag gcgggcggcc agagcgcaac ctgcgaggag gtgcgacggc 1560 agatgctggc gctggagcgc gagctggacc agcggcggcg cgagtgccag gagctgggcg 1620 cgcaggcggc cccggcgcgg cgacgtggcg aggaggccga gacacagctg caggcggcgc 1680 tgctcaaaaa cgcctggct g gcggaggaga atgggcggct gcaggccaag accgactggg 1740 tgcggaaggt ggaggctgag aatag cga agt gcg cgg cca cct ggg ccg cgc 1792 Arg Ser Ala Arg Pro Pro Gly Pro Arg 1 5 gtg tca aga gcg cga tgc ctc ccc ggc ttg atc gcc gaa cag ctg ctg 1840 Val Ser Arg Ala Arg Cys Leu Pro Gly Leu Ile Ala Glu Gln Leu Leu 10 15 20 25 cag cag gcg gcg cgc ggg cag gac agg cag cag cag ctg caa cgc gac 1888 Gln Gln Ala Ala Arg Gly Gln Asp Arg Gln Gln Gln Leu Gln Arg 30 35 40 ccg cag aag gcc ctg tgt gac ctc cat cct tcc tgg aag gag ata cag 1936 Pro Gln Lys Ala Leu Cys Asp Leu His Pro Ser Trp Lys Glu Ile Gln 45 50 55 gcg ctc cag tgt cgg cct ggt cac cct cct gaa cag ccc tgg gag acc 1984 Ala Leu Gln Cys Arg Pro Gly His Pro Pro Glu Gln Pro Trp Glu Thr 60 65 70 agt caa atg ccg gag tcc caa gtt aaa ggt agc aga agg ccc aag ttc 2032 Ser Gln Met Pro Glu Ser Gln Val Lys Gly Ser Arg Arg Pro Lys Phe 75 80 85 cac gca cgg cct gaa gac tac gca gtg tca cag ccc aac aga gac ata 2080 His Ala Arg Pro Glu Asp Tyr Ala Val Ser Gln Pro Asn Arg As p Ile 90 95 100 105 cag gag aaa agg gaa gcc tcc ctc gag gag agc cca gtt gcc ctt ggg 2128 Gln Glu Lys Arg Glu Ala Ser Leu Glu Glu Ser Pro Val Ala Leu Gly 110 115 120 gag tca gcc agt gtc ccc caa gtt tca gag aca gtc cct gcc agc caa 2176 Glu Ser Ala Ser Val Pro Gln Val Ser Glu Thr Val Pro Ala Ser Gln 125 130 135 cct ctg tcc aag aaa acc agc tcc cag tca aac tcc tcc tct gag ggg 2224 Pro Leu Ser Lys Lys Thr Ser Ser Gln Ser Asn Ser Ser Ser Glu Gly 140 145 150 tcg atg tgg gcc acc gtg ccg tcc tcc cct act ctg gac agg gac aca 2272 Ser Met Trp Ala Thr Val Pro Ser Ser Pro Thr Leu Asp Arg Asp Thr 155 160 165 gcc agt gag gtg gat gac ctg gag cct gac agc gtg tcc ctg gcc ctg 2320 Ala Ser Glu Val Asp Asp Leu Glu Pro Asp Ser Val Ser Leu Ala Leu 170 175 180 185 gaa atg ggg ggc tcg gcg gct cct gct gcc ccc aag atc ttc 2368 Glu Met Gly Gly Ser Ala Ala Pro Ala Ala Pro Lys Leu Lys Ile Phe 190 195 200 atg gct cag tat aac tac aac cca ttt gag ggg ccc aat gat cac cct 2416 Met Ala Gln Tyr Asn Tyr Asn Pro Phe Glu Gly Pro Asn Asp His Pro 205 210 215 gag ggt gag ctg ccc ctc aca gct ggg gac tac ata tat atc ttc ggg 2464 Glu Gly Glu Leu Pro Leu Thr Ala Gly Asp Tyr Ile Tyr Ile Phe Gly 220 225 230 gac atg gat gag gat ggc ttc tat gag ggg gag ctt gac gat ggc cgg 2512 Asp Met Asp Glu Asp Gly Phe Tyr Glu Gly Glu Leu Asp Asp Gly Arg 235 240 245 cgg ggg ttg gtg ccc tcc aac ttc gtg gag cag attcgacg 560g Gly Leu Val Pro Ser Asn Phe Val Glu Gln Ile Pro Asp Ser Tyr 250 255 260 265 atc cca ggc tgc ctg cct gcc aaa tcc cct gat ctt ggc ccc agt caa 2608 Ile Pro Gly Cys Leu Pro Ala Lys Ser Pro Asp Leu Gly Pro Ser Gln 270 275 280 ctc cca gcg ggg cag gat gaa gct ctg gag gaa gac agc tta tta tct 2656 Leu Pro Ala Gly Gln Asp Glu Ala Leu Glu Glu Asp Ser Leu Leu Ser 285 290 295 gg gaaa gcc gag gt gaga ggt ggg ctg tgc cag atg gtc agg 2704 Gly Lys Ala Gln Gly Val Val Asp Arg Gly Leu Cys Gln Met Val Arg 300 305 310 gtg ggc tcc aag aca gaa gta gca aca gag atc ctg gat acc aag acg 2752 Val Gly Ser Lys Thr Glu Val Ala Thr Glu Ile Leu Asp Thr Lys Thr 315 320 325 gaa gcc tgc cag ctg ggc ttg ctg cag agc atg ggg aag cag ggc ctc 2800 Glu Ala Cys Gln Leu Gly Leu Leu Gln Ser Met Gly Lys Gln Gly 340 345 tcc aga ccc ctt ctg ggg acc aaa ggg gtg ctc cgt atg gct ccc atg 2848 Ser Arg Pro Leu Leu Gly Thr Lys Gly Val Leu Arg Met Ala Pro Met 350 355 360 cag cta cac ctg cag aat gtc aca gcc aca tca gcc aac atc acc tgg 2896 Gln Leu His Leu Gln Asn Val Thr Ala Thr Ser Ala Asn Ile Thr Trp 365 370 375 gtc tac agc agc cac cgc cac ccc cat gtg gta tat ctt gat gac cga 2944 Val Tyr Ser Ser His Arg His Pro His Val Val Tyr Leu Asp Asp Arg 380 385 390 gag cat gcc ctg acc cca gcg ggc gtg agc tgc tac acc ttc cag ggc 2992 Glu His Ala Leu Thr Pro Ala Gly Val Ser Cys Tyr Thr Phe Gln Gly 395 400 405 ctg tgc ccc acg cac tac cgg gcg cgg gtg gag gtg cgg ctg cca 3040 Leu Cys Pro Gly Thr His Tyr Arg Ala Arg Val Glu Val Arg Leu Pro 410 415 420 425 cgg gac ttg ctg cag gtg tat tgg gga act atg tcc tcc acc gtc ac c 3088 Arg Asp Leu Leu Gln Val Tyr Trp Gly Thr Met Ser Ser Thr Val Thr Thr 430 435 440 ttc gac aca ctc ttg gca gga cct ccc tac cca ccg ctg gat gtg ctg 3136 Phe Asp Thr Leu Leu Ala Gly Pro Pro Tyr Pro Pro Leu Asp Val Leu 445 450 455 gtg gag cgc cat gcc tcg cca ggt gtc ctg gtg gtc agc tgg ctc cct 3184 Val Glu Arg His Ala Ser Pro Gly Val Leu Val Val Ser Trp Leu Pro 460 465 470 gtg acc att gac tca gct ggg tcc tcc aat gga gtc cag gtc acc ggt 3232 Val Thr Ile Asp Ser Ala Gly Ser Ser Asn Gly Val Gln Val Thr Gly 475 480 485 tat gct gtg gt g tat gca gat ggg ctt aag gtt tgt gag gtc gcc gat gcc 3280 Tyr Ala Val Tyr Ala Asp Gly Leu Lys Val Cys Glu Val Ala Asp Ala 490 495 500 505 act gct ggg agc acc cta ttg gaa ttc tcc cag cta cag gtg ccc ctc 3328 Thr Ala Gly Ser Thr Leu Leu Glu Phe Ser Gln Leu Gln Val Pro Leu 510 515 520 acg tgg cag aag gtc tca gtg aga acc atg tca ctc tgt ggt gag tcc 3376 Thr Trp Gln Lys Val Ser Val Arg Thr Met Ser Leu Cys Gly Glu Ser 525 530 535 535 ctg gat tca gtg cct gct cag atc ccc gag ga c ttc ttc atg tgt cac 3424 Leu Asp Ser Val Pro Ala Gln Ile Pro Glu Asp Phe Phe Met Cys His 540 545 550 cga tgg cca gag act cca ccc ttt agc tac act tgt ggc gac cca tcc 3472 Arg Trp Pro Glu Thr Pro Pro Phe Ser Tyr Thr Cys Gly Asp Pro Ser 555 560 565 acc tac aga gtc acc ttc ccc gtc tgc ccc cag aag ctg tca ctg gct 3520 Thr Tyr Arg Val Thr Phe Pro Val Cys Pro Gln Lys Leu Ser Leu Ala 570 575 575 580 585 cct ccg agt gcc aag gcc agc ccc cac aac cct gga agc tgc ggg gag 3568 Pro Pro Ser Ala Lys Ala Ser Pro His Asn Pro Gly Ser Cys Gly Glu 590 595 600 ccc cag gcc aag ttc cta gaa gca ttc ttt gaa gaa cca agg 3616 Pro Gln Ala Lys Phe Leu Glu Ala Phe Phe Glu Glu Pro Pro Arg Arg 605 610 615 caa tcc cca gtg tcc aac ctg ggc tca gaa gga gaa tgt ccg agt tca 3664 Gln Ser Pro Val Ser Asn Leu Gly Ser Glu Glu Cys Pro Ser Ser 620 625 630 ggg gct ggc agc caa gcc cag gag ctt gca gag gcc tgg gag ggc tgt 3712 Gly Ala Gly Ser Gln Ala Gln Glu Leu Ala Glu Ala Trp Glu Gly Cys 635 640 645 645 aga aag gac ctg ctc cag aag agt ccc cag aac cac agg cca cct 3760 Arg Lys Asp Leu Leu Phe Gln Lys Ser Pro Gln Asn His Arg Pro Pro 650 655 660 665 tca gtc agt gac cag cct ggg gag aag gaa aat tgc tcc cag cac atg 3808 Ser Val Ser Asp Gln Pro Gly Glu Lys Glu Asn Cys Ser Gln His Met 670 675 680 ggc acc agc aaa agc cct gct cca gga ttc atc cat cta cgc acc gag 3856 Gly Thr Ser Lys Ser Pro Ala Pro Gly Phe Ile His Leu Arg Thr Glu 685 690 695 tgt ggg ccc agg aaa gaa ccg tgt cag gaa aag gct gcc ctt gag agg 3904 Cys Gly Pro Arg Lys Glu Pro Cys Gln Glu Lys Ala Ala Leu Glu Arg 700 705 710 gta ctt cgg caa aag caa gat gcc caa g aca cct ccc cag ctg 3952 Val Leu Arg Gln Lys Gln Asp Ala Gln Gly Phe Thr Pro Pro Gln Leu 715 720 725 ggc gcc agc caa cag tat gca tct gac ttc cat aac gtt ttg aag gag 4000 Gly Ala Ser Gln Gln Tyr Ala Ser Asp Phe His Asn Val Leu Lys Glu 730 735 740 745 gag cag gag gca ctg tgc ttg gat ctg tgg ggc aca gag agg cga gag 4048 Glu Gln Glu Ala Leu Cys Leu Asp Leu Trp Gly Thr Glu Arg Arg Glu 750 755 760 gag agg agg gag cct gag ccc cac agc agg caa gga caa gct ctg ggg 4096 Glu Arg Arg Glu Pro Glu Pro His Ser Arg Gln Gly Gln Ala Leu Gly 765 770 770 775 gtg aag aga ggg tgc cag ctc cat gag ccc ggcg gc tgt cca 4144 Val Lys Arg Gly Cys Gln Leu His Glu Pro Ser Ser Ala Leu Cys Pro 780 785 790 gct cca tcc gcc aaa gtc atc aag atg ccc agg ggt ggc ccc caa cag 4192 Ala Pro Ser Ala Lys Val Ile Lys Met Pro Arg Gly Gly Pro Gln Gln 795 800 805 ctg ggg acg ggg gcc aac act cca gcc agg gtc ttt gtg gcc ctc tct 4240 Leu Gly Thr Gly Ala Asn Thr Pro Ala Arg Val Phe Val Ala Leu Ser 810 815 820 825 gat tac aac ccc ctg gtg atg tct gcc aac ctc aag gct gca gag gag 4288 Asp Tyr Asn Pro Leu Val Met Ser Ala Asn Leu Lys Ala Ala Glu Glu 830 835 840 gag ctg gtc ttc cag aaa aag cag ttg cta aga gtg tgg 4g gc tct Val Phe Gln Lys Lys Gln Leu Leu Arg Val Trp Gly Ser Gln 845 850 855 gac acc cat gat ttc tac ctc agc gag tgc aac agg caa gtg ggc aat 4384 Asp Thr His Asp Phe Tyr Leu Ser Glu Cys Asn Arg Gln Val Gly Asn 860 865 870 atc ccc ggg tgc cta gtg gct gag atg gag gtg ggg aca gag cag act 4432 Ile Pro Gly Cys Leu Val Ala Glu Met Glu Val Gly Thr Glu Gln Thr 875 880 885 gat agg agg tgg cgt tct ccg gcc ca ggg cac ctg cct tct gtg gcc 4480 Asp Arg Arg Trp Arg Ser Pro Ala Gln Gly His Leu Pro Ser Val Ala 890 895 900 905 cac ctc gag gac ttt cag ggg ctc acc atc ccc cag ggt tcc tcc ctg 4528 His Leu Glu Asp Phe Gln Gly Leu Thr Ile Pro Gln Gly Ser Ser Leu 910 915 920 gtg ctc cag ggg aac tcc aag aga ctc cca ctg tgg act cca aag atc 4576 Val Leu Gln Gly Asn Ser Lys Arg Leu Pro Leu Trp Thr Pro Lys Ile 925 930 935 atg ata gca gct ctg gac tat gat cct ggg gat ggg caa atg ggg ggc 4624 Met Ile Ala Ala Leu Asp Tyr Asp Pro Gly Asp Gly Gln Met Gly Gly 940 945 950 cag ggg aag ggc agg ctg gcg ctg agg gca atg gtt 4672 Gln Gly Lys Gly Arg Leu Ala Leu Arg Ala Gly Asp Val Val Met Val 955 960 965 tac ggg ccc atg gat gac caa gga ttc tat tat gga gag ttg ggc ggc 4720 Tyr Gly Pro Met Asp Asp Gln Gly Phe Tyr Tyr Gly Glu Leu Gly Gly 970 975 980 985 cac agg ggc ctg gtt cct gcc cac ctg ctg gat cac atg tcc ctc cat 4768 His Arg Gly Leu Val Pro Ala His Leu Leu Asp His Met Ser Leu His 990 995 1000 gga cac tgca tccttgccca ggtagtggcc tctggctgct cacaccctgc 4824 Gly His cagaggagaa gcaagcgttc agaccctcac accagcaccc ctcctcacca ccataagtag 4884 catgtgctcc aagtgccact gtgttaaact gatggtagtc cttaagcgtc ccctaggctc 4944 tgaaagtagc aggacttaag cctgagttat ttgcaaaagc aaacacaaca agccaacccc 5004 tgagagtctg agaagccatt tcaaagttgc tgataactat ggcaggtata cggagaagcg 5064 cctttttctg tggccaatgt gtgttttctc tgggaggtta aggttatctg tccattgcct 5124 tgtacgaaag tctcaagaaa agtctacatc ttaaaaaaga aaaagcaatc tgagtgttat 5184 ttttgggatg tgagggtgat ctggctgcga catgtgtcac cccattgatc atcagggttg 5244 attcggctga tctggctgac taggcgggta tccccttcct cccgcaccac tccatgtgcg 5304 tccctccaga agctgtgtgc tcaatggaag aggatgacca tccccgatag aggacgatcg 5364 gtcttcagtc aagagtataa gagtagctgc gctcccctgc tagaacctcc aaacgagctt 5424 tcagaatgtt atttttctgt ct tatgtcca acccctcatt aaaatgttca tag 5477 <210> 10 <211> 7048 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (9) .. (839) <400> 10 gaagctga gcg ctg tat cag cat cgc cct caa ggc cat cca gag caa cca 50 Ala Leu Tyr Gln His Arg Pro Gln Gly His Pro Glu Gln Pro 15 10 gcc cga ccg ggc gct ccg ctt cct gga gac ggc acagg gct gta tcc 98 Ala Arg Pro Gly Ala Pro Leu Pro Gly Glu Gly Thr Ala Ala Val Ser 15 20 25 30 gac gcc gcg agt tcg cgg gtc aag caa tgt aaa gat tac tat gag atc 146 Asp Ala Ala Ser Ser Arg Val Lys Gln Cys Lys Asp Tyr Tyr Glu Ile 35 40 45 ctg ggg gtg agc aga ggg gcc tcg gat gag gac ctg aag aag gcc tac 194 Leu Gly Val Ser Arg Gly Ala Ser Asp Glu Asp Leu Lys Lys Ala Tyr 50 55 60 cgc aga ctgcc ctc aaa ttc cac cca gac aag aac cac gca cct ggt 242 Arg Arg Leu Ala Leu Lys Phe His Pro Asp Lys Asn His Ala Pro Gly 65 70 75 gcc act gaa gcc ttc aaa gcc att ggc aca gca tat gcg gta ctc agc 290 Thr Glu Ala Phe Lys Ala Ile Gly Thr Ala Tyr Ala Val Leu Ser 80 85 90 aac ccg gag aag agg aag cag tat gac cag ttc ggc gat gac aag agc 338 Asn Pro Glu Lys Arg Lys Gln Tyr Asp Gln Phe Gly Asp Asp Lys Ser 95 100 105 110 cag gc g gcc cgg cac ggc cat ggg cat ggg gat ttc cac cgt ggc ttt 386 Gln Ala Ala Arg His Gly His Gly His Gly Asp Phe His Arg Gly Phe 115 120 125 gag gcc gac atc tcc cct gaa gac ctc ttc aac atg ttc ttt gg ggc 434 Glu Ala Asp Ile Ser Pro Glu Asp Leu Phe Asn Met Phe Phe Gly Gly 130 135 140 ggc ttc cct tct agt aac gtc cac gtc tac agc aac ggc cgc atg cgc 482 Gly Phe Pro Ser Ser Asn Val His Val Tyr Sern Gly Arg Met Arg 145 150 155 tat acc tac cag caa agg cag gac cgc agg gac aac cag ggt gat gtg 530 Tyr Thr Tyr Gln Gln Arg Gln Asp Arg Arg Asp Asn Gln Gly Asp Val 160 165 170 agt gag gag ggc gcc agg gac agc gcg gga agg gca cca aat cca ccc 578 Ser Glu Glu Gly Ala Arg Asp Ser Ala Gly Arg Ala Pro Asn Pro Pro 175 180 185 190 cag gga ggg ggc ttg gag gag ggt gtt ccc tcc cac act gtc cat tct 626 Gln Gly Gly Gly Leu Glu Glu Gly Val Pro Ser His Thr Val His Ser 195 200 205 ggg acc agc aga gtc ccc ata act ctc agc caa gga gcc ctc tgg gcc 674 Gly Thr Ser Arg Val Pro Ile Thr Leu Ser Gln Gly Ala Leu Trp Ala 210 twenty one 5 220 tcc ctt gcc att ctg ctg agt gac acc aga ggg cgc cac acg agg gag 722 Ser Leu Ala Ile Leu Leu Ser Asp Thr Arg Gly Arg His Thr Arg Glu 225 230 235 cca tgc tcc aca ttg ccg gcg gga gcg cgg ctt tgg cct ggc tgg 770 Pro Cys Ser Thr Leu Pro Ala Gly Ala Arg Leu Cys Trp Pro Gly Trp 240 245 250 gga gtg gaa cca gaa acc cca ccc gca gcc agg ttt gag tgt gag gct 818 Gly Val Glu Pro Glu Thr Pro Pro Ala Ala Arg Phe Glu Cys Glu Ala 255 260 265 270 ccc atg cag acc gct cgc tgg taaggccaaa gtgacatcct ctaagcaatg 869 Pro Met Gln Thr Ala Arg Trp 275 gaaagttaca ctttgtgaga gaattttatt ttatttttca tttttttcat gggtctcagc 929 tattttctct caactttgtg agagaaattt cttttttttt aattgagatg gagtcttgct 989 ctctcgcccg ggctgagtgc agtggcgcga tctcggctca ctgcagcctc cgcctcccgg 1049 gttcaagccg ttctcctgcc tcagcctccc gagtaactgg gattacgggt gcgtgccacc 1109 acccccggct aattttgtat ttttggtgga gatggggttt caccatgttg gccaggctgg 1169 tctcgaactc ctgacctcgt gcctcccctgcc gcctccctccc gcctccc gcctccc gcc ttttga gacagggtct cgttctgtca 1289 ccctggctag agtgcaggag cctcccctcc caggcaaagc tcccgcctca ggctccccag 1349 tagctgggac cacaggccca caccaccaca cccagctaat tttttgtatt ttttgtagag 1409 atagggtctt actttgctgt ttgagcacag gctggtctca aactcttggg ctcaagtggt 1469 cctcctgcct cggcctccca cagtgctggg attacaggca tgagccattg cccctgatca 1529 aaattttttt attttgtatc taacaacaga agagtttaac atcacagatt atcacacagt 1589 gaatatattt gttaattttt atttctaatt cttctttttt tgtttgtttg ctttttctgc 1649 actctagaac cagtgctatt tctaattttt attttgtttt aattattatt ttttgtagag 1709 atgggggtgt atgttggcca gactggtctt gaactcctgg cctcacgtgt tcctctcatg 1769 ttggtctccc aaagtgttgg gattacaggc atgagccgcc acactggcca taatgtttaa 1829 attggtaata tatttgtgtg gttcacatct caaaaacttg tatatactgc atgtctcctt 1889 ccagccctgc cttccattct cctggaggaa gcaacttttg ctgatttttt tttttttttg 1949 gcattctgtc aaaagtaaat gcagacacct cacttcctcc tgtatttcac accagttgct 2009 gctttgtttt tatctgggaa agctggcagg tgaaggagcg tctgtgtttt ggagcctcgt 2069 ggagggaacg gcagagtggt gtcatgtctc cccaggctc c actattctag gggagctagt 2129 ggtgattatg gctgacacca caccccaccc aggtccagca gagtgacatt ggctcttccc 2189 tccagggcgg gctaggggtg tttgtgcagc tgatgcctat cctcatcctg attctcgtgt 2249 cagctctcag ccagctcatg gtctccagtc caccctacag tctgagtcca agaccgtgag 2309 tacatgggtg aggccgggcc atgggcagac aaggggcttt aaattctcag ccccatcagg 2369 ggccttcttt cccatcctga tccagccagt gtgcgatcat aatgcagaaa cctggcttcg 2429 aatcaagaaa atatactttc tctattcaac taggactctt aagcttttta ggattatggt 2489 cccctaagaa attgcagcga gagctacaga acttttccct aaaactatgc acacatgtgc 2549 acacacacat acacacacac gatacacatg tacacacaca cacaatacat gcacacacat 2609 aatacacatg cacacataca cgcacacata tacacacaga gttttgcata taatttcggc 2669 ggctttgtga ctcttccctg cccatctccc ctgccaaccc tgacgaagaa cctctgctcc 2729 tcggctctgg ttgggcttcc tgaggctgtg gagagaacag ggcactagag tcagacagag 2789 caagcatggc ttagaatccc agcttctcca ctaagaggct gtgtgaccct aaacaagtta 2849 tataaccttg gtttcctcat ctataaaatg ggaattataa catccacctg ctgtggaaat 2909 taatgagtaa tgcatataaa atgtctggcc cactagaaat gctc aacaat attagtttaa 2969 tgagtgctta gtctcgactg ccaggagtga acttgaggac atttcatgag ccgttagggg 3029 gtcagctccc ctcactgatg tccagcacct ggcccagggt cagctacaca gtgggtgcac 3089 atcttcagtg gggtgggtcc ccctctccca aaaggtggcc acctctggct gggagctggc 3149 aggacccttc tcagccagca gggggcagag tcggtccact ggaccctggc cgccggctca 3209 ggctccctgt ggccagatgc cagccctttt ccctgcaact ggagagatgt gaggagcaga 3269 ggactagggc agggactgtt gtccccagag cactggtcct gtctgggtgt caaggctctt 3329 cccacagctg acagagcctg tgattggagc tgggaggata aggctccctg gagcccttcc 3389 tgtcattttg ttcctaagcc tcttaaccct acactgggaa ctcctggata ggcaggcaag 3449 cactcagcaa caattggctt aggggatgaa tggggagatg gaggcacgga ggcagagccc 3509 agattccctc tcaggtctcc agttccctag accaggcctc tccccaaagg ccccaggtca 3569 gcagtgtggt aagcagggat ctaaaggcag ggcgtcctgc ggtctgggcc acgtgtgtgg 3629 gaggacgctg ccttttcctc agactctcct ttcagggagt gtgcgggtcc ctgctctggt 3689 ttgagaggga accaactact cctctggtct gtgcggcacc tcctgtcttg gggcccatac 3749 ccctagagtg ccctgggcat ggggacccgc acccactttg aacctggta t ttctggccag 3809 gtccgtgggc cacatccaca ggcgagtcac tgaccacctg ggtgtcgtct actatgtggg 3869 agacactttc tccgaagagt acacaggctc cagcctcaaa acagtcgagc ggaatgtgga 3929 agatgattat atcgccaacc tccggaacaa ctgctggaag gagaagcagc agaaggaagg 3989 cttgctgtac cgggcacgct actttggcga cacagatatg taccacagag cacagaagat 4049 gggcaccccc agctgcagcc gactgtcaga ggtgcaggcc tccctgcatg gatagtcctg 4109 ggccagccac accaccgagg tccaagtatg agccagggct gcctccaccc tgcaactcct 4169 ggcagctttg gccctggtca tgagcagagg agggaggggg agaaagggag gaagcctggt 4229 gattgtggca aagactcctg tccccagcct gacctccagc ctccagagac cgagcagctg 4289 tggggcctgc tgggaaacca aggtcggttt ccgccctcta gcgatgctgt cctccccact 4349 cctccgctct gctccctggc tccaggggtg tgggggaccc cagaaccagg cagagtggga 4409 acttgaaact gttgctgagg gccacccggg gcttcttggt ccactccagc catcagtcag 4469 cacggccctt tctccagcac agcagactat tgtccgtgcc ctggtattta ggccatcaca 4529 tatggtgggg cccaagagag ccccatatgc acactgcctg cctgatacca ggaagaacca 4589 tgtgggaata ggtgggccaa gagccctccc ctttctccat ccctccagct agg aggaaat 4649 ggagcaagat gaacaggcag ccacgaggtg ggtgggagct ggcagtcttg gtggcggcag 4709 gggccgcggg ccctgaccac ccccctctgg tgggatctga ggcactctct cgaatgccgt 4769 cacacctggc agcctggaag ccacaggcat ccggccttgc ccaggcatct cgcctgcggt 4829 ctgaggaagg gaacagaagg tcatgagttc agggtcagac gcagccgctc agcacaggag 4889 gggtggaggg gaaatgagag ttgctggtag caggctccct ccttctgcag cccggcgaat 4949 gggggcgctg ggctctgttc ccagcgtttg ccagaggtgg ccacttcagc caagcccgga 5009 gaagtgtggg cagaagcagt gaaggttctt ctctgtgtgg gtgccctgcc caccccctcc 5069 tttgcctgtg tcctcccggc ctggatccat ggctgactct gcctggaggc catttgtgcc 5129 tgcctctgtg ctgccgcagg agggcaggcc gcaagtgggg ttggtggggg tcgagcgggc 5189 agcacggtgc agcggtgcag tggcaagggg ggctacttgt gtggcataag ctagaggagc 5249 cggtgccgcc tgaatgccga gctaactgtt gccactctcc tccccagact atgaaatccc 5309 tggagaattt ttggtgacat gcactgagcc aaggtgatgg actgtatatt tgaggaaaga 5369 caaacaaaga aacaaaatta aaatggaatt ggaggccgaa cgctgcacag ctgccctctc 5429 tctcacccag taaatgcaga aagctcttag gacagacaga aaacctgcca tggggctgc t 5489 tccctccctc gcagggctgg cggaggctcc gcatcgcctc tctcctagga tacagaaacc 5549 atggcaacga aagtagaatg taaaactcgc agcagatatc agtgggaagg gctgggggag 5609 ggggcaccca gctgcctttc ctccctcaca ggagccacca ccagccacct ctcaggagaa 5669 gccagaggcc ctggccaaag ataggaggaa gaaagagaac tctccataga atgtaattta 5729 tagatgcgtg tatatgtata tatatctatt tatatgtaaa taggcatata tgaagatata 5789 tatatatagt ctacttttta aactctgcag ggatttggtt aagttgttga gctgatttct 5849 tccatgtttt agaaaatgag gcctgtttgg ggaaggtacc ctggtgatgt ttttgctaga 5909 cattagctgt agctgacagc ataaggagag tcgcatcaga gcttttcaca gccccccgaa 5969 accccagcct ggttttgatg gcagcagtaa tcatgatagt gtgaacccgc gaaggcctca 6029 ggattatggt taacctggag aggagcaggc catggaggca ggtgccaggt cagtattgag 6089 tcacagtaga ggccccacaa ggacctgctt gggtgagacc acctctcccc tctcagcagc 6149 gctggtgggc tctttgtcct ggtgcccagg agccctccag ccccctgccc acagaaggga 6209 aggcctgcag agggggccag gatctaccta accatttccc cacccctaag tccctcagtg 6269 ggctttgcct tataggtgcc acagggcaca gctccatcat tgccactggt ttttcctaag 632 9 tcatgcacca aggacttcag aaagttcttc ctccgagtca gtcagtggtg ccgggacccc 6389 agggcagcct cctcgactcc tgaagaaaag gcagtgcccg tggctgcctc tgtcttcact 6449 cgctgttgat gtgaccgcca ggcctcctct cgtaccttgg acaaaggata cacctgaacc 6509 agaatagttt tcttaccctc acattgaaat gaggattttg cttaaaacag cacttgccgc 6569 cagtgggagg agggaggttt tatttattcc cacagtttct cctgggcctt ctggaatgac 6629 catgttttcc tgtggcggtg ggtgtgtcat tgcgcccgcc gtcttccaaa gccttacttc 6689 cccaagctgc cagccaggag gtgataacca ccctcccaga gtttctctcg gctctttttt 6749 taaaagtccc ccaacaaata ggattcttgc tgggaaagga agttcggtaa ggaaatgtca 6809 aatctggttt ttaaacaagg tccaaccctg caatgaagca gccacttcag cccagagaga 6869 ttataagaac tgatgtggcc agagtgccta cccactgtgg ccccggtgct ctgcccccac 6929 gccccgacca tctggtcttg gtagatgtcc ctagacgggc tgagccatgt gcaataagaa 6989 catagatcct aaaggatcct ctggaagctg tatttcttga attagaattc tcaaattgt 7048 <210> 11 <211> 6693 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (4437) <400> 11 att ggc tgc gag cag gcg ggt gtg gag tac cgc ctg gtg cag gat gcc 48 Ile Gly Cys Glu Gln Ala Gly Val Glu Tyr Arg Leu Val Gln Asp Ala 1 5 10 15 tac ctg agc cgg ccc ggc cgt gcc gcc cac cag ctg ggc ctg gct 96 Tyr Leu Ser Arg Pro Gly Arg Ala Leu Ala His Gln Leu Gly Leu Ala 20 25 30 gag gac gag gac gtg ctg ttc act gtg ttc gcc cag ggc cag aag aac 144 Glu Asp Glu Asp Val Phe Thr Val Phe Ala Gln Gly Gln Lys Asn 35 40 45 cgc gtg aag cca cca aag gag tca gca ctg tgc ctg ttc acg ctc agg 192 Arg Val Lys Pro Pro Lys Glu Ser Ala Leu Cys Leu Phe Thr Leu Arg 50 55 60 gcc atc aag gag aag att aag gag cgc atc cag tcc tgc tac cgt ggt 240 Ala Ile Lys Glu Lys Ile Lys Glu Arg Ile Gln Ser Cys Tyr Arg Gly 65 70 75 80 gag ggc aag ctc tcc ctg ccg tgg ctg ag ag ggc tgc 288 Glu Gly Lys Leu Ser Leu Pro Trp Leu Leu Asn Lys Glu Leu Gly Cys 85 90 95 atc aac tcg ccc ctg cag atc gat gac gac ttc tgc ggg cag gac ttc 336 Ile Asn Ser Pro Leu Gln Ile Asp Asp Asp Asp Asp Cys Gly Gln Asp Phe 100 105 11 0 aac cag ccc ctg ggg ggc aca gtc acc att gag ggg acg ccc ctg ttc 384 Asn Gln Pro Leu Gly Gly Thr Val Thr Ile Glu Gly Thr Pro Leu Phe 115 120 125 gtg gac aag gat gat ggc ctg acc gcc gtg gct gcc tat gac tat cgg 432 Val Asp Lys Asp Asp Gly Leu Thr Ala Val Ala Ala Tyr Asp Tyr Arg 130 135 140 ggc cgc act gtg gta ttc gcc ggc acg cga agt ggc cgc atc cgc aag 480 Gly Arg Thr Val Val Phe Ala Gly Thrg Ser Gly Arg Ile Arg Lys 145 150 155 160 atc ctg gtg gac ctc tca aac ccc ggt ggc cgg cct gcc ctg gcc tac 528 Ile Leu Val Asp Leu Ser Asn Pro Gly Gly Arg Pro Ala Leu Ala Tyr 165 170 175 gag agc gtc gcc cag gag ggc agc ccc atc ctg cga gac ctc gtc 576 Glu Ser Val Val Ala Gln Glu Gly Ser Pro Ile Leu Arg Asp Leu Val 180 185 190 ctc agc ccc aac cac cag tac ctc tac gcc atg acc gag aag cag gtg 624 Ser Pro Asn His Gln Tyr Leu Tyr Ala Met Thr Glu Lys Gln Val 195 200 205 acg cgg gtg cct gtg gag agc tgt gtg cag tac acg tcc tgt gag ctg 672 Thr Arg Val Pro Val Glu Ser Cys Val Gln Tyr Thr Ser Cys Glu Le u 210 215 220 tgt ctg ggg tca cgg gac ccc cac tgt ggc tgg tgt gtc ctg cac agc 720 Cys Leu Gly Ser Arg Asp Pro His Cys Gly Trp Cys Val Leu His Ser 225 230 235 240 atc tgc tcg cgg cgg gac gcc tgt gag cga gca gac gag ccc cag cgc 768 Ile Cys Ser Arg Arg Asp Ala Cys Glu Arg Ala Asp Glu Pro Gln Arg 245 250 255 ttt gct gcg gac ctg ctg cag tgt gtg cag ctg act gtg cag ccc cgc 816 Phe Ala Ala Asla Gln Cys Val Gln Leu Thr Val Gln Pro Arg 260 265 270 aat gtg tct gtc acc atg tcc cag gtc cca ctt gtg ctg cag gcc tgg 864 Asn Val Ser Val Thr Met Ser Gln Val Pro Leu Val Leu Gln Ala Trp 275 280 285 aac gtg cct gac ctc tca gct ggc gtc aac tgc tcc ttc gag gac ttc 912 Asn Val Pro Asp Leu Ser Ala Gly Val Asn Cys Ser Phe Glu Asp Phe 290 295 300 acg gaa tct gag agc gtc ctg gag gat gc cg cg cg cc gc cg cc gc gc cg cc gc gc gc cc gc gc gc cc gc cc gc gc ccgc tca 960 Thr Glu Ser Glu Ser Val Leu Glu Asp Gly Arg Ile His Cys Arg Ser 305 310 315 320 ccc tcc gcc cgg gag gtg gcg ccc atc acg cgg ggc cag gga gac cag 1008 Pro Ser Ala Arg Glu Val Ala Pro Ile Thr Arg G ly Gln Gly Asp Gln 325 330 335 cgg gtg gtg aaa ctc tac cta aag tcc aag gag aca ggg aag aag ttt 1056 Arg Val Val Lys Leu Tyr Leu Lys Ser Lys Glu Thr Gly Lys Lys Phe 340 345 350 gcg tct gtg gactt ttc tac aac tgc agc gtc cac cag tcc tgc 1104 Ala Ser Val Asp Phe Val Phe Tyr Asn Cys Ser Val His Gln Ser Cys 355 360 365 ctg tcc tgt gtc aac ggc tcc ttt ccc tgc cac tgg tgc aaa tac cgc Leu Val Asn Gly Ser Phe Pro Cys His Trp Cys Lys Tyr Arg 370 375 380 cac gtg tgc aca cac aac gtg gct gac tgc gcc ttc ctg gag ggc cgt 1200 His Val Cys Thr His Asn Val Ala Asp Cys Ala Phe Leu Glu Gly Arg 385 390 395 400 gtc aac gtg tct gag gac tgc cca cag atc ctg ccc tcc acg cag atc 1248 Val Asn Val Ser Glu Asp Cys Pro Gln Ile Leu Pro Ser Thr Gln Ile 405 410 415 tac gtg cca gtg gga gtg gta aaa ccc atc acc ctg gcc gca cgg aac 1296 Tyr Val Pro Val Gly Val Val Lys Pro Ile Thr Leu Ala Ala Arg Asn 420 425 430 ctg cca cag cca cag tca ggc cag cgt gga tat gag tgc ctc ttc cac 1344 Leu Pro Gln Pro Gln Ser G ly Gln Arg Gly Tyr Glu Cys Leu Phe His 435 440 445 atc ccg ggc agc ccg gcc cgt gtc acc gcc ctg cgc ttc aac agc tcc 1392 Ile Pro Gly Ser Pro Ala Arg Val Thr Ala Leu Arg Phe Asn Ser Serg 450c ctg cag tgc cag aat tcc tcg tac tcc tac gag ggg aac gat gtc 1440 Ser Leu Gln Cys Gln Asn Ser Ser Tyr Ser Tyr Glu Gly Asn Asp Val 465 470 475 475 480 agc gac ctg cca gtg aac ctg tca gtc gtg gtc gtc gtc ttt gtc 1488 Ser Asp Leu Pro Val Asn Leu Ser Val Val Trp Asn Gly Asn Phe Val 485 490 495 att gac aac cca cag aac atc cag gcg cac ctc tac aag tgc ccg gcc 1536 Ile Asp Asn Pro Gln Asn Ile Gln Ala His Leu Tyr Lys Cys Pro Ala 500 505 510 ctg cgc gag agc tgc ggc ctc tgc ctc aag gcc gac ccg cgc ttc gag 1584 Leu Arg Glu Ser Cys Gly Leu Cys Leu Lys Ala Asp Pro Arg Phe Glu 515 g gg tc gag cgc cgc tgc tcc ctg cga cac cac tgc 1632 Cys Gly Trp Cys Val Ala Glu Arg Arg Cys Ser Leu Arg His His Cys 530 535 540 gct gcc gac aca cct gca tcg tgg atg cac gcg cgt cac ggc agc agg agt 1 a Asp Thr Pro Ala Ser Trp Met His Ala Arg His Gly Ser Ser 545 550 555 560 cgc tgc acc gac ccc aag atc ctc aag ctg tcc ccc gag acg ggc ccg 1728 Arg Cys Thr Asp Pro Lys Ile Leu Lys Leu Ser Pro Glu Thr Gly Pro 565 570 575 agg cag ggc ggc acg cgg ctc act atc aca ggc gag aac ctg ggc ctg 1776 Arg Gln Gly Gly Thr Arg Leu Thr Ile Thr Gly Glu Asn Leu Gly Leu 580 585 590 590 cga ttc gaa gtg cgt cgc gtg ggc aag gtg ctg tgc 1824 Arg Phe Glu Asp Val Arg Leu Gly Val Arg Val Gly Lys Val Leu Cys 595 600 605 agc cct gtg gag agc gag tac atc agt gcg gag cag atc gtc tgt gag 1872 Ser Val Tyr Ile Ser Ala Glu Gln Ile Val Cys Glu 610 615 620 atc ggg gac gcc agc tcc gtg cgt gcc cat gac gcc ctg gtg gag gtg 1920 Ile Gly Asp Ala Ser Ser Val Arg Ala His Asp Ala Leu Val Glu Val 625 630 635 640 tgt gtg cgg gac tgc tca cca cac tac cgc gcc ctg tca ccc aag cgc 1968 Cys Val Arg Asp Cys Ser Pro His Tyr Arg Ala Leu Ser Pro Lys Arg 645 650 655 ttc acc ttc gtg aca cca acc ttc tac cgt gtg ag tcc cgt ggg 2016 Phe Thr Phe Val Thr Pro Thr Phe Tyr Arg Val Ser Pro Ser Arg Gly 660 665 670 cct ctg tca ggg ggc acc tgg att ggc atc gag gga agc cac ctg aac 2064 Pro Leu Ser Gly Gly Thr Trp Ile Gly Ile Glu Gly Ser His Leu Asn 675 680 685 gca ggc agt gat gtg gct gtg tcg gtc ggt ggc cgg ccc tgc tcc ttc 2112 Ala Gly Ser Asp Val Ala Val Ser Val Gly Gly Arg Pro Cys Ser Phe 690 695 700 tcc tgg agg aac tcc cgt gag atc cgg tgc ctg aca ccc ccc ggg cag 2160 Ser Trp Arg Asn Ser Arg Glu Ile Arg Cys Leu Thr Pro Pro Gly Gln 705 710 715 720 agc cct ggc agc gct ccc atc atc atc aac atc aac cgc gcc cag ctc 2 Pro Gly Ser Ala Pro Ile Ile Ile Asn Ile Asn Arg Ala Gln Leu 725 730 735 acc aac cct gag gtg aag tac aac tac acc gag gac ccc acc atc ctg 2256 Thr Asn Pro Glu Val Lys Tyr Asn Tyr Thr Glu Asp Pro Thr Ile Leu 740 745 750 agg atc gac ccc gag tgg agc atc aac agc ggt ggg acc ctc ctg acg 2304 Arg Ile Asp Pro Glu Trp Ser Ile Asn Ser Gly Gly Thr Leu Leu Thr 755 760 765 gtc aca ggc acc aac ctg gcc act g tc cgt gaa ccc cga atc cgg gcc 2352 Val Thr Gly Thr Asn Leu Ala Thr Val Arg Glu Pro Arg Ile Arg Ala 770 775 780 aag tat gga ggc att gag agg gag aac ggc tgc ctg gtg tac aat gac 2400 Lys Tyr Gly Gly Glu Arg Glu Asn Gly Cys Leu Val Tyr Asn Asp 785 790 795 800 acc acc atg gta tgc cgc gcc ccg tct gtg gcc aac cct gtg cgc agc 2448 Thr Thr Met Val Cys Arg Ala Pro Ser Val Ala Asn Pro Val Arg Ser 805 810 815 cca cca gag ctg ggg gag cgg ccg gat gag ctg ggc ttc gtc atg gac 2496 Pro Pro Glu Leu Gly Glu Arg Pro Asp Glu Leu Gly Phe Val Met Asp 820 825 830 aac gtg cgc tcc ctg ctt gtc accc ctc tac tac 2544 Asn Val Arg Ser Leu Leu Val Leu Asn Ser Thr Ser Phe Leu Tyr Tyr 835 840 845 cct gac ccc gta ctg gag cca ctc agc ccc act ggc ctg ctg gag ctg 2592 Pro Asp Pro Val Leu Glu Pro Leu Ser Pro Thr Gly Leu Leu Glu Leu 850 855 860 aag ccc agc tcc cca ctc atc ctc aag ggc cgg aac ctc ttg cca cct 2640 Lys Pro Ser Ser Pro Leu Ile Leu Lys Gly Arg Asn Leu Leu Pro Pro 865 870 875 875 880 gca ccc g gc aac tcc cga ctc aac tac acg gtg ctc atc ggc tcc aca 2688 Ala Pro Gly Asn Ser Arg Leu Asn Tyr Thr Val Leu Ile Gly Ser Thr 885 890 895 ccc tgt acc ctc acc gtg tcg gag acg caa ctg ctg tgc gg 2736 Pro Cys Thr Leu Thr Val Ser Glu Thr Gln Leu Leu Cys Glu Ala Pro 900 905 910 aac ctc act ggg cag cac aag gtc acg gtg cgg gca ggt ggc ttc gag 2784 Asn Leu Thr Gly Gln His Lys Val Thr Val Arg Ala Gly Gly Phe Glu 915 920 925 ttc tcg cca ggg aca ctg cag gtg tac tcg gac agc ctg ctg acg ctg 2832 Phe Ser Pro Gly Thr Leu Gln Val Tyr Ser Asp Ser Leu Leu Thr Leu 930 935 940 940 cct gcc att gtg gg ggc ggg ggt ctc ctg ctg ctg gtc 2880 Pro Ala Ile Val Gly Ile Gly Gly Gly Gly Gly Leu Leu Leu Leu Val 945 950 955 960 atc gtg gct gtg cta atc gcc tac aag cgc aag tca cga gat gct Gac 29 Leu Ile Ala Tyr Lys Arg Lys Ser Arg Asp Ala Asp 965 970 975 cgc aca ctc aag cgg ctg cag ctc cag atg gac aac ctg gag tcc cgc 2976 Arg Thr Leu Lys Arg Leu Gln Leu Gln Met Asp Asn Leu Glu Ar 0 985 990 gtg gcc ctc gaa tgc aag gaa gcc ttt gca gag ctg cag aca gac atc 3024 Val Ala Leu Glu Cys Lys Glu Ala Phe Ala Glu Leu Gln Thr Asp Ile 995 1000 1005 cac gag ctg acc aat gac gtg gac atc ccc ttc ctt gac 3072 His Glu Leu Thr Asn Asp Leu Asp Gly Ala Gly Ile Pro Phe Leu Asp 1010 1015 1020 tac cgg aca tat gcc atg cgg gtg ctc ttt cct ggg atc gag gac cac 3120 Tyr Arg Thr Tyr Ala Met Val Leu Phe Pro Gly Ile Glu Asp His 1025 1030 1035 1040 cct gtg ctc aag gag atg gag gtg cag gcc aat gtg gag aag tcg ctg 3168 Pro Val Leu Lys Glu Met Glu Val Gln Ala Asn Val Glu Lys Ser Leu 1045 1050g 55ca ttc ggg cag ctg ctg acc aag aag cac ttc ctg ctg acc ttc 3216 Thr Leu Phe Gly Gln Leu Leu Thr Lys Lys His Phe Leu Leu Thr Phe 1060 1065 1070 atc cgc acg ctg gag gca cag cgc agc ttgccc 3264 Ile Arg Thr Leu Glu Ala Gln Arg Ser Phe Ser Met Arg Asp Arg Gly 1075 1080 1085 aat gtg gcc tcg ctc atc atg acg gcc ctg cag ggc gag atg gaa tac 3312 Asn Val Ala Ser Leu Ile Met T hr Ala Leu Gln Gly Glu Met Glu Tyr 1090 1095 1100 gcc aca ggc gtg ctc aag cag ctg ctt tcc gac ctc atc gag aag aac 3360 Ala Thr Gly Val Leu Lys Gln Leu Leu Ser Asp Leu Ile Glu Lys Asn 1105 1110 1115 gag agc aag aac cac ccc aag ctg cta ctg cgc cgg act gag tcg 3408 Leu Glu Ser Lys Asn His Pro Lys Leu Leu Leu Arg Arg Thr Glu Ser 1125 1130 1135 gtg gca gag aag atg cta act aac tgg ttc acc ttc ttc aag 3456 Val Ala Glu Lys Met Leu Thr Asn Trp Phe Thr Phe Leu Leu Tyr Lys 1140 1145 1150 ttc ctc aag gag tgc gct ggg gag ccg ctg ttc atg ctg tac tgc gcc 3504 Phe Leu Lys Glu Cys Ala Ghe Glu Leu Tyr Cys Ala 1155 1160 1165 atc aag cag cag atg gag aag ggc ccc att gac gcc atc acg ggt gag 3552 Ile Lys Gln Gln Met Glu Lys Gly Pro Ile Asp Ala Ile Thrhr Gly Glu 1170 1175 1180 gca cgc tac gcc ctg gac aag ctc atc cgg cag cag att gac 3600 Ala Arg Tyr Ser Leu Ser Glu Asp Lys Leu Ile Arg Gln Gln Ile Asp 1185 1190 1195 1200 tac aag aca ctg acc ctg aac tgt gtg aac cct gag aat gag aat gca 3648 Tyr Lys Thr Leu Thr Leu Asn Cys Val Asn Pro Glu Asn Glu Asn Ala 1205 1210 1215 cct gag gtg ccg gtg aag ggg ctg gac tgt gac acg gtc acc cag gcc 3696 Pro Glu Val Pro Val Lys Gly Leu Asp Cys Asp Thr Val Thr Gln Ala 1220 1225 1230 aag gag aag ctg ctg gac gct gcc tac aag ggc gtg ccc tac tcc cag 3744 Lys Glu Lys Leu Leu Asp Ala Ala Tyr Lys Gly Val Pro Tyr Ser Gln 1235 1240 1245 cgg ccc aag gcc gc gac atg gac ctg gag tgg cgc cag ggc cgc atg 3792 Arg Pro Lys Ala Ala Asp Met Asp Leu Glu Trp Arg Gln Gly Arg Met 1250 1255 1260 gcg cgc atc atc ctg cag gac gag gac gtc acc acc aag att gac Ile Ile Leu Gln Asp Glu Asp Val Thr Thr Lys Ile Asp Asn 1265 1270 1275 1280 gat tgg aag agg ctg aac aca ctg gct cac tac cag gtg aca gac ggg 3888 Asp Trp Lys Arg Leu Asn Thr Leu Ala His Tyr Gln Val Thr Asp Gly 1285 1290 1295 tcc tcg gtg gca ctg gtg ccc aag cag acg tcc gcc tac aac atc tcc 3936 Ser Ser Val Ala Leu Val Pro Lys Gln Thr Ser Ala Tyr Asn Ile Ser 1300 1305 1310 aac tcc tc c acc ttc acc aag tcc ctc agc aga tac ggt gag ggg cca 3984 Asn Ser Ser Thr Phe Thr Lys Ser Leu Ser Arg Tyr Gly Glu Gly Pro 1315 1320 1325 ggc agc ggg cga gag ggc agc gca tgg gtc cct ggc ggg ggc 4032 Gly Ser Gly Arg Glu Gly Ser Ala Trp Val Pro Gly Leu Gly Arg Thr 1330 1335 1340 tcc ccc ggg ctc cca cgc tgc agc agc cgg acg gga gga ccc agg ggc 4080 Ser Pro Gly Leu Pro Arg Cys Ser Ser Arg Thr Gly Gly Pro Arg Gly 1345 1350 1355 1360 agg tgt caa gcc tgt cac tcg cac tct tgg cct tac cct cca gct ctg 4128 Arg Cys Gln Ala Cys His Ser His Ser Trp Pro Tyr Pro Pro Ala Leu 1365 1370 1375 gag gct gcg cct cct cgc gac tgt gtg tcc gta cac aat tat gcc acc 4176 Glu Ala Ala Pro Pro Arg Asp Cys Val Ser Val His Asn Tyr Ala Thr 1380 1385 1390 tct gtg gtg tca tcg gct gcc cca aaa tcc cac atg ggt ggg ggt gcc 4224 Ser Val Val Ser Ser Ala Ala Pro Lys Ser His Met Gly Gly Gly Ala 1395 1400 1405 atc ccc agc ttt cag atg ggg aaa cag gct cgg gcg ggg ggt gcg ggg 4272 Ile Pro Ser Phe Gln Met Gly Lys Gln Ala Arg Ala Gly Gly Ala Gly 1410 1415 1420 tgc cag cca acg cgg gcg ctg aca gcc tgg tgc tgc aga gag cat gct 4320 Cys Gln Pro Thr Arg Ala Leu Thr Ala Trp Cys Cys Arg Glu His Ala 1425 1430 1435 1440 gcg cac gcc ca cga cag cct gcg ctc gcg cac gcc cat gat 4368 Ala His Gly Gln Gln Pro Arg Gln Pro Ala Leu Ala His Ala His Asp 1445 1450 1455 cac gcc cga cct gga gag cgg cac caa gct gtg gca cct ggt gaa gaa Arla Pro Gly Glu Arg His Gln Ala Val Ala Pro Gly Glu Glu 1460 1465 1470 cca cga cca cct gga cca gcg tgagggtgac cgcggcagca agatggtctc 4467 Pro Arg Pro Pro Gly Pro Ala 1475 ggagatctac ttgacacggc tactggccac caagggcaca ctgcagaagt ttgtggacga 4527 cctgtttgag accatcttca gcacggcaca ccggggctca gccctgccgc tggccatcaa 4587 gtacatgttc gacttcctgg atgagcaggc cgacaagcac cagatccacg atgctgacgt 4647 gcgccacacc tggaagagca actgcctgcc cctgcgcttc tgggtgaacg tgatcaagaa 4707 cccacagtc gtcacgc cctcgc gag ttcacgc gag ttcacgcactg 4827 ctccaacaag ctgctctacg ccaaggacat ccccaactac aagagctggg tggagaggta 4887 ctatgcagac atcgccaaga tgccagccat cagcgaccag gacatgagtg cgtatctggc 4947 tgagcagtcc cgcctgcacc tgagccagtt caacagcatg agcgccttgc acgagatcta 5007 ctcctacatc accaagtaca aggatgagat cctggcagcc ctggagaagg atgagcaggc 5067 gcggcggcag cggctgcgga gcaagctgga gcaggtggtg gacacgatgg ccctgagcag 5127 ctgagcccca gctgtgatca tccagcatga tgcagcgtga ggacagctga gcagggaccg 5187 ggacagccct caccgcatgc gtgtggagtg tccggtggtg ctcgggccgc cgcagtgcag 5247 cgactgcccg gccctccctc ccctgcctca cccggtcggg tcccggctct tcctgtgtgg 5307 aggtgatggt acctgccaca ccacagctgc gcacacagct gcttgctcag gggccgggac 5367 agcactgggt gctcaggctg gccaaggacc ttcattgcct ggcaagagct gcccagtggc 5427 cttcatggga gaagggctga cctctgaggg gctgaggggt gaggccaggg ccctccaggg 5487 ggaggggtag ccagcttggg ctgtcccctt gagaccagga caagaggctg ggggtgtcag 5547 cattcccagc tttccaagct gcccccaggc ggcagagtct gagggtcccg gggcccggtt 5607 ggcagctgga gaaagaggca aaaagcccgt agccgggcaa gaggagctca agtcggtctg 5667 ggcccgttgc caccgactcc cacctccagc acccatgccc gctgcaccgc tgccatcctc 5727 agattcaccg cgtgctctgc gcggccgagg ccggagcacc acatccacct cgccccagag 5787 aggctctgct ccctcctatg gaggggctgt gggccaggct gctcagactc ctgggtggct 5847 tccagacgga ccgggcagcc cctctccgtc ctcagggctg tgcctctggg agccactggg 5907 ccaggggccc cgggtcgcag agagcacgtt cccgttattt attcccctcc gcgtcctaca 5967 caggctgccc tggcagctgt cttcaagggt aggctgagct ccccaccctg gagcccctga 6027 gggcggcccc tgagcactcc tctctctcca ctctctctgt ccctgcccca gcggcttcca 6087 gtgtggcatc tcagcagtgt cctggcccct ccagagcagt gggacatctg gggactgttt 6147 ttgtgtttag ggaaaaaaat tctgctgcac tctgcttggg ccttgaggtc tgtggcaggg 6207 ctcctctggc ccgcagtggc ctggatctat ctgggccatg agtgacgggc agtgaccaga 6267 gggactggag gccagcggtg tccacccttg ccctcagcaa gagagaatgc attcttaaaa 6327 gaaagctgta catgtatata tatgcatata tatatatgtg gctctagcct caggctccag 6387 ccccagtggg gtactgtaca gttaactgaa gaagaatttt aaagacgatt tgaacaagaa 6447 aatgaaggca gtgggaaagc aatgccaaat ggttgtggag aaagtggccg gagcctccct 6507 ggagtg gagc agccctgaag cctgtgcccc ccgacctgcg ggccgctgtt ttggtttgac 6567 atgacaagga aaggacttcc tgctgaccct gagagcctct ggggtgccgc ggcaccacgg 6627 ggcatgcatg attgtgctag cgtttagtgagatt gattgatgatttgattgagattgattaggattaggattgattaggattaggattaggattgattaggattagtaggattagtaggattaggattaggattaggattaggagattag <210> 12 <211> 6678 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (77) .. (5356) <400> 12 gagcggccca tggacccgcg gggcccggcg ccccagactc tgcgccgtcg ggacggagcc 60 caagatgtcg gcctag gcc ggg gcg cga cga cgc gga cgg ggc ggc gag gg ggc gag gg gc gg gg gcc gc gc gc gc gc gc gc gc gc gc gc gc gc gcc gag ccc ccg agg gcg cgc 160 Ala Pro Leu Leu Pro Gly Leu Ala Ala Ala Glu Pro Pro Arg Ala Arg 15 20 25 cct gac gga ctg gcc gag ccg gcg gtg aga ggc cgg cgc gtc ggg agc 208 Pro Asp Glu Leu Pro Ala Val Arg Gly Arg Arg Val Gly Ser 30 35 40 ggg ccg cgc ggc acc atg tcg gcc aag gtg cgg ctc aag aag ctg gag 256 Gly Pro Arg Gly Thr Met Ser Ala Lys Val Arg Leu Lys Lys Leu Glu 45 50 55 60 cag ctg ctc ctg gac ggg ccc tgg cgc aac gag agc gcc ctg agc gtg 304 Gln Leu Leu Leu Asp Gly Pro Trp Arg Asn Glu Ser Ala Leu Ser Val 65 70 75 gaa acg ctg ctc gac gtg ctc tc gc accc agc cac 352 Glu Thr Leu Leu Asp Val Leu Val Cys Leu Tyr Thr Glu Cys Ser His 80 85 90 tcg gcc ctg cgc cgc gac aag tac gtg gcc gag ttc ctc gag tgg gct 400 Ser Ala Leu Arg Arg A sp Lys Tyr Val Ala Glu Phe Leu Glu Trp Ala 95 100 105 aaa cca ttt aca cag ctg gtg aaa gaa atg cag ctt cat cga gaa gac 448 Lys Pro Phe Thr Gln Leu Val Lys Glu Met Gln Leu His Arg Glu Asp 110 115 120 ttt gaa ata att aaa gta att gga aga ggt gct ttt ggt gag gtt gct 496 Phe Glu Ile Ile Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala 125 130 135 140 gtt gtc aaa atg aag aat act gaa cga att tat gca atg aaa atc ctc 544 Val Val Lys Met Lys Asn Thr Glu Arg Ile Tyr Ala Met Lys Ile Leu 145 150 155 aac aag tgg gag atg ctg aaa aga gca gag acc gcg tgc ttc cga gag 592 Asn Lys Trp Glu Met Leu Glu Ag Ala Thr Ala Cys Phe Arg Glu 160 165 170 gag cgc gat gtg ctg gtg aac ggc gac tgc cag tgg atc acc gcg ctg 640 Glu Arg Asp Val Leu Val Asn Gly Asp Cys Gln Trp Ile Thr Ala Leu 175 180 185 cac tac gcc ttt gac gag aac cac ctg tat tta gtc atg gat tac 688 His Tyr Ala Phe Gln Asp Glu Asn His Leu Tyr Leu Val Met Asp Tyr 190 195 200 tat gtg ggt ggt gat tta ctg acc ctg ctc agc aaa ttt gaa gyr aag 736 G ly Gly Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Lys 205 210 215 220 ctt ccg gaa gat atg gcg agg ttc tac att ggt gaa atg gtg ctg gcc 784 Leu Pro Glu Asp Met Ala Arg Phe Tyr Ile Gly Glu Met Val Ala 225 230 235 att gac tcc atc cat cag ctt cat tac gtg cac aga gac att aaa cct 832 Ile Asp Ser Ile His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro 240 245 250 gac aat gtc ctt ttg gac gtg aat ggt cat atc cgc ctg gct gac ttt 880 Asp Asn Val Leu Leu Asp Val Asn Gly His Ile Arg Leu Ala Asp Phe 255 260 265 gga tca tgt ttg aag atg aat gat gat ggc act gtg cag tcc tcc gtg 928 Gly Ser Cys Leu Lys Met Asp Asp Gly Thr Val Gln Ser Ser Val 270 275 280 gcc gtg ggc aca cct gac tac atc tcg ccg gag atc ctg cag gcg atg 976 Ala Val Gly Thr Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met 285 290 290 300 gag gac ggc atg ggc aaa tac ggg cct gag tgt gac tgg tgg tct ctg 1024 Glu Asp Gly Met Gly Lys Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu 305 310 315 ggt gtc tgc atg tat gag atg ctc tat gga gat acgcg 1072 Gly Val Cys Met Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala 320 325 330 gag tca ctc gtg gag acc tat ggg aag atc atg aac cat gaa gag cga 1120 Glu Ser Leu Val Glu Thr Tyr Gly Lys Ile Met Asn His Glu Glu Arg 335 340 345 ttc cag ttc cca tcc cat gtc acg gat gta tct gaa gaa gcg aag gac 1168 Phe Gln Phe Pro Ser His His Thr Thr Asp Val Ser Glu Glu Ala Lys Asp 350 355 360 ctc atc cag aga ctg atc tg agt aga gaa cgc cgg ctg ggg cag aat 1216 Leu Ile Gln Arg Leu Ile Cys Ser Arg Glu Arg Arg Leu Gly Gln Asn 365 370 375 380 gga ata gag gat ttc aaa aag cat gcg ttt ttt gaa ggt cta aly tgg 1264 G Asp Phe Lys Lys His Ala Phe Phe Glu Gly Leu Asn Trp 385 390 395 gaa aat ata cga aac cta gaa gca cct tat att cct gat gtg agc agt 1312 Glu Asn Ile Arg Asn Leu Glu Ala Pro Tyr Ile Pro Asp Val Ser Ser 400 405 410 ccc tct gac aca tcc aac ttc gac gtg gat gac gac gtg ctg aga aac 1360 Pro Ser Asp Thr Ser Asn Phe Asp Val Asp Asp Asp Val Leu Arg Asn 415 420 425 acg gaa ata tta cct cct ggt tct cac aca g gc ttt tct gga tta cat 1408 Thr Glu Ile Leu Pro Pro Gly Ser His Thr Gly Phe Ser Gly Leu His 430 435 440 ttg cca ttc att ggt ttt aca ttc aca acg gaa agc tgt ttt tct gat 1456 Leu Pro Phe Ile Gly Phe Thr Phe Thr Thr Glu Ser Cys Phe Ser Asp 445 450 455 460 cga ggc tct ctg aag agc ata atg cag tcc aac aca tta acc aaa gat 1504 Arg Gly Ser Leu Lys Ser Ile Met Gln Ser Asn Thr Leu Thr Lys Asp 465 470 475 gag gat gtg cag cgg gac ctg gag cac agc ctg cag atg gaa gct tac 1552 Glu Asp Val Gln Arg Asp Leu Glu His Ser Leu Gln Met Glu Ala Tyr 480 485 490 gag agg agg att cgg agg ctg gag ag gag ag gag ag gag ag agg 1600 Glu Arg Arg Ile Arg Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg 495 500 505 aag ctg caa gag tcc acc cag acc gtg cag tcc ctc cac ggc tca tct 1648 Lys Leu Gln Glu Ser Thr Gln Thr Val Gln Ser Leu His Gly Ser Ser 510 515 520 cgg gcc ctc agc aat tca aac cga gat aaa gaa atc aaa aag cta aat 1696 Arg Ala Leu Ser Asn Ser Asn Arg Asp Lys Glu Ile Lys Lys Leu Asn 525 530 535 535 540 gaa gaa cgaa c ttg aag aat aaa ata gca gat tca aac agg ctc 1744 Glu Glu Ile Glu Arg Leu Lys Asn Lys Ile Ala Asp Ser Asn Arg Leu 545 550 555 gag cga cag ctt gag gac aca gtg gcg ctt cgc caa gag cgt gag gag g792 Arg Gln Leu Glu Asp Thr Val Ala Leu Arg Gln Glu Arg Glu Asp 560 565 570 tcc acg cag cgg ctg cgg ggg ctg gag aag cag cac cgc gtg gtc cgg 1840 Ser Thr Gln Arg Leu Arg Gly Leu Glu Lys Gln His Arg Val Arg 575 580 585 cag gag aag gag gag ctg cac aag caa ctg gtt gaa gcc tca gag cgg 1888 Gln Glu Lys Glu Glu Leu His Lys Gln Leu Val Glu Ala Ser Glu Arg 590 595 600 ttg aaa tcc cag gcc aag gaact gcc cat cag cag cga aag 1936 Leu Lys Ser Gln Ala Lys Glu Leu Lys Asp Ala His Gln Gln Arg Lys 605 610 615 620 ctg gcc ctg cag gag ttc tcg gag ctg aac gag cgc atg gca gag ctc 1984 Leu Ala Leu Ser Glu Leu Asn Glu Arg Met Ala Glu Leu 625 630 635 cgt gcc cag aag cag aag gtg tcc cgg cag ctg cga gac aag gag gag 2032 Arg Ala Gln Lys Gln Lys Val Ser Arg Gln Leu Arg Asp Lys Glu Glu 640 645 65 0 gag atg gag gtg gcc acg cag aag gtg gac gcc atg cgg cag gaa atg 2080 Glu Met Glu Val Ala Thr Gln Lys Val Asp Ala Met Arg Gln Glu Met 655 660 665 cgg aga gct gag aag ctc agg aaa gag ctgga ctt gat gat 2128 Arg Arg Ala Glu Lys Leu Arg Lys Glu Leu Glu Ala Gln Leu Asp Asp 670 675 680 gct gtt gct gag gcc tcc aag gag cgc aag ctt cgt gag cac agc gag 2176 Ala Val Ala Glu Ala Ser Lys Glu Arg Leu Arg Glu His Ser Glu 685 690 695 700 aac ttc tgc aag caa atg gaa agc gag ctg gag gcc ctc aag gtg aag 2224 Asn Phe Cys Lys Gln Met Glu Ser Glu Leu Glu Ala Leu Lys Val Lys 705 710 715 cag gga gcg ggt gcc acc tta gag cac cag caa gag att 2272 Gln Gly Gly Arg Gly Ala Gly Ala Thr Leu Glu His Gln Gln Glu Ile 720 725 730 tcc aaa atc aaa tcc gag ctg gag aag aaa gtc tta ttt tat gaa gag 23 Lys Ile Lys Ser Glu Leu Glu Lys Lys Val Leu Phe Tyr Glu Glu 735 740 745 gaa ttg gtc aga cgt gag gcc tcc cat gtg cta gaa gtg aaa aat gtg 2368 Glu Leu Val Arg Arg Glu Ala Ser His Val Leu Glu Val Lys Asn Val 750 755 760 aag aag gag gtg cat gat tca gaa agc cac cag ctg gcc ctg cag aaa 2416 Lys Lys Glu Val His Asp Ser Glu Ser His Gln Leu Ala Leu Gln Lys 765 770 775 780 gaa atc ttg atg tta aaaat tta gaa aag tca aag cga gaa cgg 2464 Glu Ile Leu Met Leu Lys Asp Lys Leu Glu Lys Ser Lys Arg Glu Arg 785 790 795 cat aac gag atg gag gag gca gta ggt aca ata aaa gat aaa tac gaa 2512 G Asa Glu Mlu Glu Ala Val Gly Thr Ile Lys Asp Lys Tyr Glu 800 805 810 cga gaa aga gcg atg ctg ttt gat gaa aac aag aag cta act gct gaa 2560 Arg Glu Arg Ala Met Leu Phe Asp Glu Asn Lys Lys Leu Thr Ala Glu 815 820 aat gaa aag ctc tgt tcc ttt gtg gat aaa ctc aca gct caa aat aga 2608 Asn Glu Lys Leu Cys Ser Phe Val Asp Lys Leu Thr Ala Gln Asn Arg 830 835 840 cag ctg gag gat gag ctg cag gat agag gag ag tca gtg 2656 Gln Leu Glu Asp Glu Leu Gln Asp Leu Ala Ala Lys Lys Glu Ser Val 845 850 855 860 gcc cac tgg gaa gct cag att gcg gaa atc att cag tgg gtc agt gac 2704 Ala His Trp Glu Ala Gln Ile Ala Glu Ile Ile Gln Trp Val Ser Asp 865 870 875 gag aaa gat gcc cgg ggt tac ctt caa gct ctt gct tcc aag atg acc 2752 Glu Lys Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr 880 885 890 890 gaa gag ctc gag gct ttg agg agt tct agt ctg ggg tca aga aca ctg 2800 Glu Glu Leu Glu Ala Leu Arg Ser Ser Ser Leu Gly Ser Arg Thr Leu 895 900 905 gac ccg ctg tgg aag gtg cgc cgc agc cag aag ctg gac atg 848 Asp Pro Leu Trp Lys Val Arg Arg Ser Gln Lys Leu Asp Met Ser Ala 910 915 920 cgg ctg gag ctg cag tcg gcc ctg gag gcg gag atc cgg gcc aag cag 2896 Arg Leu Glu Leu Gln Ser Ala Leu Glu Ala Glu Ile Arg Lys Gln 925 930 935 940 ctt gtc cag gag gag ctc agg aag gtc aag gac gcc aac ctc acc ttg 2944 Leu Val Gln Glu Glu Leu Arg Lys Val Lys Asp Ala Asn Leu Thr Leu 945 950 955 gaa ag cat g gcc aaa aac aga gaa tta tta gaa 2992 Glu Ser Lys Leu Lys Asp Ser Glu Ala Lys Asn Arg Glu Leu Leu Glu 960 965 970 gaa atg gaa att ttg aag aaa aag atg gaa gaa aaa ttc aga gca gat G40 Glu 3040 Ile Leu Lys Lys Lys Met Glu Glu Lys Phe Arg Ala Asp 975 980 985 act ggg ctc aaa ctt cca gat ttt cag gat tcc att ttt gag tat ttc 3088 Thr Gly Leu Lys Leu Pro Asp Phe Gln Asp Ser Ile Phe Glu Tyr Phe 990 995 1000 aac act gct cct ctt gca cat gac ctg aca ttt aga acc agc tca gct 3136 Asn Thr Ala Pro Leu Ala His Asp Leu Thr Phe Arg Thr Ser Ser Ala 1005 1010 1015 1020 agt gag caa gaa aca caa gct ccg aag cca gaa gcg tcc ccg tcg atg 3184 Ser Glu Gln Glu Thr Gln Ala Pro Lys Pro Glu Ala Ser Pro Ser Met 1025 1030 1035 tct gtg gct gca tca gag cag cag gag gac atg gct cgg ccc ccg cag 3232 Ser Val Ala Ala Ser Glu Gln Gln Glu Asp Met Ala Arg Pro Pro Gln 1040 1045 1050 agg cca tcc gct gtg ccg ttg ccc acc acg cag gcc ctg gct ctg gct 3280 Arg Pro Ser Ala Val Pro Leu Pro Thr Thr Gln Ala Leu Ala Leu Ala 1055 1060 1065 gga ccg aag cca aaa gct cac cag ttc agc atc aag tcc ttc tcc agc 3328 Gly Pro Lys Pro Lys Ala His Gln Phe Ser Ile Lys Ser Phe Ser Ser 1070 1075 1080 cct act cag tgc agc cac tgc acc tcc ctg atg g tt ggg ctg atc cgg 3376 Pro Thr Gln Cys Ser His Cys Thr Ser Leu Met Val Gly Leu Ile Arg 1085 1090 1095 1100 cag ggc tac gcc tgc gag gtg tgt tcc ttt gct tgc cac gtg tcc tgc 3424 Gln Gly Tyr Ala Cys Glu Cys Ser Phe Ala Cys His Val Ser Cys 1105 1110 1115 aaa gac ggt gcc ccc cag gtg tgc cca ata cct ccc gag cag tcc aag 3472 Lys Asp Gly Ala Pro Gln Val Cys Pro Ile Pro Pro Glu Gln Ser Lys 1120 1125 1130 agg cct ctg ggc gtg gac gtg cag cga ggc atc gga aca gcc tac aaa 3520 Arg Pro Leu Gly Val Asp Val Gln Arg Gly Ile Gly Thr Ala Tyr Lys 1135 1140 1145 ggc cat gtc aag gtc cca aag ccc acg ggg gtg aag ag 3568 Gly His Val Lys Val Pro Lys Pro Thr Gly Val Lys Lys Gly Trp Gln 1150 1155 1160 cgc gca tat gca gtc gtc tgt gac tgc aag ctc ttc ctg tat gat ctg 3616 Arg Ala Tyr Ala Val Val Cys Asp Cys Lys Leu Phe Tyr Asp Leu 1165 1170 1175 1180 cct gaa gga aaa tcc acc cag cct ggt gtc att gcg agc caa gtc ttg 3664 Pro Glu Gly Lys Ser Thr Gln Pro Gly Val Ile Ala Ser Gln Val Leu 1185 1190 1195 gat ctc aga gat gac gag ttt tcc gtg agc tca gtc ctg gcc tca gat 3712 Asp Leu Arg Asp Asp Glu Phe Ser Val Ser Ser Val Leu Ala Ser Asp 1200 1205 1210 gtc att cat gct aca cgc cga gat att cca tgg atattc gtg acg 3760 Val Ile His Ala Thr Arg Arg Asp Ile Pro Cys Ile Phe Arg Val Thr 1215 1220 1225 gcc tct ctc tta ggt gca cct tct aag acc agc tcg ctg ctc att ctg 3808 Ala Ser Leu Leu Gly Ala Pro Ser Lys Thr Ser Ser Leu Leu Ile Leu 1230 1235 1240 aca gaa aat gag aat gaa aag aag aag tgg gtt ggg att cta gaa gga 3856 Thr Glu Asn Glu Asn Glu Lys Lys Lys Trp Val Gly Ile Leu Glu Gly 1245 1250 1255 1260 ctc cttccc cat aaa aac cgg ctg agg aat cag gtc gtg cat 3904 Leu Gln Ser Ile Leu His Lys Asn Arg Leu Arg Asn Gln Val Val His 1265 1270 1275 gtt ccc ttg gaa gcc tac gac agc tcg ctg cct ctc atc aag gcc atc 39 Leu Glu Ala Tyr Asp Ser Ser Leu Pro Leu Ile Lys Ala Ile 1280 1285 1290 ctg aca gct gcc atc gtg gat gca gac agg att gca gtc ggc cta gaa 4000 Leu Thr Ala Ala Ile Val Asp Ala Asp A rg Ile Ala Val Gly Leu Glu 1295 1300 1305 gaa ggg ctc tat gtc ata gag gtc acc cga gat gtg atc gtc cgt gcc 4048 Glu Gly Leu Tyr Val Ile Glu Val Thr Arg Asp Val Ile Val Arg Ala 1310 1315 1320 gct gacgt aag gta cac cag atc gag ctt gct ccc agg gag aag 4096 Ala Asp Cys Lys Lys Val His Gln Ile Glu Leu Ala Pro Arg Glu Lys 1325 1330 1335 1340 atc gta atc ctc ctc tgt ggc cgg aac cac cat gtg cac ccc tatc Ile Val Ile Leu Leu Cys Gly Arg Asn His His Val His Leu Tyr Pro 1345 1350 1355 tgg tcg tcc ctt gat gga gcg gaa ggc agc ttt gac atc aag ctt ccg 4192 Trp Ser Ser Leu Asp Gly Ala Glu Gly Ser Phe Asp Ile Lys Leu Pro 1360 1365 1370 gaa acc aaa ggc tgc cag ctc atg gcc acg gcc aca ctc aag agg aac 4240 Glu Thr Lys Gly Cys Gln Leu Met Ala Thr Ala Thr Leu Lys Arg Asn 1375 1380 1385 tct ggc acc tgc ctg ttt gtg aaa cgg ctg atc ctt tgc tat 4288 Ser Gly Thr Cys Leu Phe Val Ala Val Lys Arg Leu Ile Leu Cys Tyr 1390 1395 1400 gag atc cag aga acg aag cca ttc cac aga aag ttc aat gag att gtg 4336 Glu Ile Gln Arg Thr Lys Pro Phe His Arg Lys Phe Asn Glu Ile Val 1405 1410 1415 1420 gct ccc ggc agc gtg cag tgc ctg gcg gtg ctc agg gac agg ctc tgt 4384 Ala Pro Gly Ser Val Gln Cys Leu Ala Val Asp Arg Leu Cys 1425 1430 1435 gtg ggc tac cct tct ggg ttc tgc ctg ctg agc atc cag ggg gac ggg 4432 Val Gly Tyr Pro Ser Gly Phe Cys Leu Leu Ser Ile Gln Gly Asp Gly 1440 1445 1450 cag cct gta aac ccc aat gac ccc tcg ctt gcg ttc ctc 4480 Gln Pro Leu Asn Leu Val Asn Pro Asn Asp Pro Ser Leu Ala Phe Leu 1455 1460 1465 tca caa cag tct ttt gat gcc ctt tgt gct gtg gag ctc gaa agc Gag 4528 SerGln Phe Asp Ala Leu Cys Ala Val Glu Leu Glu Ser Glu 1470 1475 1480 gag tac ctg ctt tgc ttc agc cac atg gga ctg tac gtg gac ccg caa 4576 Glu Tyr Leu Leu Cys Phe Ser His Met Gly Leu Tyr Val Asp Pro Gln 1495 1500 ggc cgg agg gca cgc gcg cag gag ctc atg tgg cct gcg gct cct gtc 4624 Gly Arg Arg Ala Arg Ala Gln Glu Leu Met Trp Pro Ala Ala Pro Val 1505 1510 1515 gcc tgt agt tgc ag c ccc acc cac gtc acg gtg tac agc gag tat ggc 4672 Ala Cys Ser Cys Ser Pro Thr His Val Thr Val Tyr Ser Glu Tyr Gly 1520 1525 1530 gtg gac gtc ttt gat gtg cgc acc atg gag tgg gtg cag acc atc ggc 4720 Val Asp Val Phe Asp Val Arg Thr Met Glu Trp Val Gln Thr Ile Gly 1535 1540 1545 ctg cgg agg ata agg ccc ctg aac tct gaa ggc acc ctc aac ctc ctc 4768 Leu Arg Arg Ile Arg Pro Leu Asn Ser Glu Gly Thr Leu Asu Le Leu 1550 1555 1560 aac tgc gag cct cca cgc ttg atc tac ttc aag agc aag ttc tcg gga 4816 Asn Cys Glu Pro Pro Arg Leu Ile Tyr Phe Lys Ser Lys Phe Ser Gly 1565 1570 1575 1580 gcg gtt tcc cac gac acc g gac aac agc aag aag cag atg 4864 Ala Val Leu Asn Val Pro Asp Thr Ser Asp Asn Ser Lys Lys Gln Met 1585 1590 1595 ctg cgc acc agg agc aaa agg cgg ttc gtc ttc aag gtc cca gag gaa 4912 Leu Arg Thrg Serg Arg Arg Phe Val Phe Lys Val Pro Glu Glu 1600 1605 1610 gag aga ctg cag cag agg cga gag atg ctt aga gac cca gaa ttg aga 4960 Glu Arg Leu Gln Gln Arg Arg Glu Met Leu Arg Asp Pro Glu Leu Arg 1615 1620 1625 tcc aaa atg ata tcc aac cca acc aac ttc aac cac gtg gcc cac atg 5008 Ser Lys Met Ile Ser Asn Pro Thr Asn Phe Asn His Val Ala His Met 1630 1635 1640 ggc cca ggc gac ggc atg cag gtg ctg atg gac ctg cct ctg agt gct 5056 Gly Pro Gly Asp Gly Met Gln Val Leu Met Asp Leu Pro Leu Ser Ala 1645 1650 1655 1660 gtg ccc ccc tcc cag gag gaa agg ccg ggc ccc gct ccc acc aac ctg 5104 Val Pro Pro Ser Gln Glu Glu Arg Pro Gly Pro Ala Pro Thr Asn Leu 1665 1670 1675 gct cgc cag cct cca tcc agg aac aag ccc tac atc tcg tgg ccc tca 5152 Ala Arg Gln Pro Pro Ser Arg Asn Lys Pro Tyr Ile Ser Trp Pro Ser 1680 1685 1690 tca ggt gga tcg gag cct agc gtg act gtg cct ctg aga agt atg tct 5200 Ser Gly Gly Ser Glu Pro Ser Val Thr Val Pro Leu Arg Ser Met Ser 1695 1700 1705 gat cca gac cag gac ttt gac aaa gag cct gat tcg gac tcc acc aaa 5248 Asp Pro Asp Gln Asp Phe Asp Lys Glu Pro Asp Ser Asp Ser Thr Lys 1710 1715 1720 cac tca act cca tcg aat agc tcc aac ccc agc ggc cca ccg agc ccc 5296 His Ser Thr Pro Ser Asn Ser Ser Asn Pro Ser Gly Pro Pro Ser Pro 1725 1730 1735 1740 aac tcc ccc cac agg agc cag ctc ccc ctc gaa ggc ctg gag cag ccg 5344 Asn Ser Pro His Arg Ser Gln Leu Pro Leu Glu Gly Leu Glu Gln Pro 1745 1750 1755 gcc tgt gac acc tgaagccgcc agctcgccac aggggccagg gagctggaga 5396 Ala Cys Asp Thr 1760 tggcctccag cgtcagtgcc aagactgagc gggccctcca gtgttgtcca aggaaatgta 5456 gaatcacttt gtagatatgg agatgaagaa gacaaatctt tattataata ttgatcagtt 5516 ttatgccgca ttgttcgtgg cagtagacca catctgttcg tctgcacagc tgtgaggcga 5576 tgctgttcca tctgcacatg aaggaccccc atacagcctg tctcccaccc ctgacaaccc 5636 gagagggcat atggggccct gccaacacca cttcctcagc agaaacccgt catgacgcgg 5696 ctgcttcgga agcagacatc tggggacaca gcctcagtac ccagtctttt ccctagttcc 5756 tgaaactttc ctaggacctt aagagaatag taggaggtcc tatagcattc ccagtgtcac 5816 tagaattttg aagacaggaa agtggaggtt agtctgtggc ctttttttca tttagccatt 5876 gcacagtcag ctgcagaagt cctgctgacc acctagtcat ggacaaaggc ccaggaccag 5936 tgacaccctg cgtccctgtg tgcattaagt tcattctggg tcgcagccat ga agtgtcac 5996 cagtatctac tactgtgaag tcagctgtgc tgttttccat tcgcttccac ggcttctgcc 6056 tcctgccata aaaccagcga gtgtcgtggt gcaggcaggc cctgtggcct gctgggctga 6116 gggaagtcag agccccaggg cgccacgaag cagccactgg gataccccac cccgccccgc 6176 cctgcccgcc ccccccccac cagtcctgcc cccgcatgga gcccccgtga ttagtagccc 6236 gtatgatcac gtagacccac ccaacacact cctgcacact ggccccggcc cacggcacag 6296 caatcccctg cgcgtggatt tcacctcacc ctttgtacca gatgttgagt gaccagctct 6356 gtggccctgt gtcgtcagag gcttgtgatt aactgtggcg gcagacacag cttgtccaca 6416 gcttgggcca ggcttcccct gtcctcccac cggtcggctg cttggcaagg ctgttcagga 6476 cgtgcacttc cccaagtcgg cactgagtgg cccagcaccg cctagccctg ccaccccact 6536 gccctcctgg gccttctgct ggatgggcac ctggggggtt ctggttttta cttttttaat 6596 gtaagtctca gtctttgtaa ttaattattg aattgtgaga acatttttga acaatttacc 6656 tgtcaataaa gcagaagacg gc 6678 <210> 13 <211> 6382 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (82) .. (1695) <400> 13 ggctgctgct ctcagcggcg gggctcgcca gcgcttcagt gggcggggac gcggcaggtg 60 actccagacc aaggaggatg a gct gct gtc cct gga aga gaa cgg atg gag 111 Ala Ala Val Pro Gly Arg Gg ag gc gg gc gg gc gg gc gc gg gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gct gct gat ctg gag 159 Gly Ser Ser Ser Tyr Glu Val Pro Ser Val Ala Ala Ala Asp Leu Glu 15 20 25 gag ggt gct ggt cag act agg agc ttg cct gcc acc ccc tcc aaa gat 207 Glu Gly Ala Gly Gln Thr Arg Ser Leu Pro Ala Thr Pro Ser Lys Asp 30 35 40 gtt cac aag ggt gtt gga ggc atc atc ttt tcc tcc tca ccg att tta 255 Val His Lys Gly Val Gly Gly Ile Ile Phe Ser Ser Ser Pro Ile Leu 45 50 55 gac ttg agt gaa agt ggt ctg tgc cgt ttg gag gag gtc ttt aga atc 303 Asp Leu Ser Glu Ser Gly Leu Cys Arg Leu Glu Glu Val Phe Arg Ile 60 65 70 ccc agc ctt caa caa ttg cat ctg caa agg aat gcc ctg tgt gtg att Ser Leu Gln Gln Leu His Leu Gln Arg Asn Ala Leu Cys Val Ile 75 80 85 90 cct caa gat ttc ttt cag ttg ctt ccg aac ctg act tgg ctg gac ctc 399 Pro Gln Asp Phe Phe Gln Leu Leu Pro Asn Leu Thr Trp Leu Asp Leu 95 100 105 cgg tac aat aga att aaa gcg ctt cct tct ggg att gga gct cac cag 447 Arg Tyr Asn Arg Ile Lys Ala Leu Pro Ser Gly Ile Gly Ala His Gln 110 115 120 cat ttg aaa act ttg ctt tta gaa aga aat cct atc aaa atg tta cct 495 His Leu Lys Thr Leu Leu Leu Glu Arg Asn Pro Ile Lys Met Leu Pro 125 130 135 gtg gag ctg ggg agc gta acc acg ctg aaa gca ctg aac cta aga cac Val Glu Leu Gly Ser Val Thr Thr Leu Lys Ala Leu Asn Leu Arg His 140 145 150 tgc cct ctg gaa ttc cct cct cag ctc gtt gtg cag ag gga ttg gtg 591 Cys Pro Leu Glu Phe Pro Pro Gln Leu Val Val Gln Lys Gly Leu Val 155 160 165 170 gct atc cag cgc ttc ctg cgg atg tgg gca gta gaa cac tct ctc ccc 639 Ala Ile Gln Arg Phe Leu Arg Met Trp Ala Val Glu His Ser Leu Pro 175 180 185 aga aat cca act tct caa gag gct cca ccg gtt aga gag atg acc ctc 687 Arg Asn Pro Thr Ser Gln Glu Ala Pro Pro Val Arg Glu Met Thr Leu 190 195 200 cgt gac ctc ccg agc cca gga ctg gag ttg tct gga gac cac gcg tct 735 Arg Asp Leu Pro Ser Pro Gly Leu Glu Leu Ser Gly Asp His Ala Ser 205 210 215 aac caa gga gct gtg aac gct cag gac cca gag ggg gct gtg atg aaa 783 Asn Gln Gly Ala Val Asn Ala Gln Asp Pro Glu Gly Ala Val Met Lys 220 225 230 gag aag gcc agc ttt ctc cca cct gtg gaa aag cca gac ctg agt gaa 831 Glu Lys Ala Ser Phe Leu Pro Pro Val Glu Lys Pro Asp Leu Ser Glu 235 240 245 250 ctc agg aag tct gcg gac tcc tca gag ag tgg ccc gag gag gag 879 Leu Arg Lys Ser Ala Asp Ser Ser Glu Asn Trp Pro Ser Glu Glu Glu 255 260 265 atc agg cgc ttt tgg aag ctg agg cag gag att gtt gag cac gtg aag 927 Ile Arg Arg Phe Trp Lys Leu Arg Gln Glu Ile Val Glu His Val Lys 270 275 280 gca gac gtt ctg gga gat cag ctc ttg acg agg gaa tta cct cca aat 975 Ala Asp Val Leu Gly Asp Gln Leu Leu Thr Arg Glu Leu Pro Pro Asn 285 290 295 ctc att gcg gcc aac att gag aaa gaa cta cca aag cca aga cac 1023 Leu Lys Ala Ala Leu Asn Ile Glu Lys Glu Leu Pro Lys Pro Arg His 300 305 310 gtt ttc aga agg aag aca gcc tcc tcc agg agc atc tta ccc gac ctc 1071 Val he Arg Arg Lys Thr Ala Ser Ser Arg Ser Ile Leu Pro Asp Leu 315 320 325 330 ttg tca ccg tac caa atg gcg atc cga gca aaa aga ctg gaa gag agc 1119 Leu Ser Pro Tyr Gln Met Ala Ile Arg Ala Lys Arg Leu Glu Glu Ser 335 340 345 cga gcg gcg gcg ctc cga gag ctc cag gag aag cag gct ctg atg gag 1167 Arg Ala Ala Ala Leu Arg Glu Leu Gln Glu Lys Gln Ala Leu Met Glu 350 355 360 cag cag aga cga gag ag cag gag tgg aga gag cga gcc 1215 Gln Gln Arg Arg Glu Lys Arg Ala Leu Gln Glu Trp Arg Glu Arg Ala 365 370 375 cag agg atg agg agg aag agg aag gaa gag ctc agc aaa ctc ctg cct ccg 1263 Gln Arg Lys Glu Glu Leu Ser Lys Leu Leu Pro Pro 380 385 390 cgg agg agc atg gtg gca tca aag att ccc tct gcc aca gat ctg ata 1311 Arg Arg Ser Met Val Ala Ser Lys Ile Pro Ser Ala Thr Asp Leu Ile 395 400 405 410 gat aac agg aaa gta cca ctg aat ccg cct gga aaa atg aaa cca agc 1359 Asp Asn Arg Lys Val Pro Leu Asn Pro Pro Gly Lys Met Lys Pro Ser 415 420 425 aaa gag aaa tcg cca caa gca agt aaa gaa atg agt gcc ctg cag gag 1407 Lys Glu Lys Ser Pro Gln Ala Ser Lys Glu Met Ser Ala Leu Gln Glu 430 435 440 aga aat tta gaa gag aag ata aaa cag cac gtc ctc caa atg cgt gag 1455 Arg Asn Leu Glu Glu Lys Hisle Lysln Val Leu Gln Met Arg Glu 445 450 455 caa aga aga ttc cat ggc cag gcc cca ctg gag gag atg agg aag gct 1503 Gln Arg Arg Phe His Gly Gln Ala Pro Leu Glu Glu Met Arg Lys Ala 460 465 470 gcc gag gat ga t g att gcc aca gag cta cag gat gaa gta ttg aag 1551 Ala Glu Asp Leu Glu Ile Ala Thr Glu Leu Gln Asp Glu Val Leu Lys 475 480 485 490 490 cta aaa ttg gga tta acc ttg aac aaa gat cgt cga cgg gcg gcc cc gcc gcc ccc gcg gcc cc Lys Leu Gly Leu Thr Leu Asn Lys Asp Arg Arg Arg Ala Ala Leu 495 500 505 act gga aac ctt tcg ctt ggc ctg ccg gca gca cag cct caa aat aca 1647 Thr Gly Asn Leu Ser Leu Gly Leu Pro Ala Ala Gln Pro Gln Asn Thr 510 515 520 ttt ttt aac aca aaa tat gga gaa tca gga aat gtt cgc aga tac cag 1695 Phe Phe Asn Thr Lys Tyr Gly Glu Ser Gly Asn Val Arg Arg Tyr Gln 525 530 535 tgacaccagg tggctggact gatggagacg tcttcagaca ggagccgctc agtcttcttt 1755 cccgggcgtc gcctcctgtg tggtgccgga agagcgccag gttcagtgtt accctgaggg 1815 ctgatttcgc gcagcctgtt gttttcctta gacaggtcca cgtccctctc ctgaggctgt 1875 ggaagatttc agccgtatta aaagaaagga cactgtgagc acgtggtctc gccttccctt 1935 cttcctgcag gttcccgcca agccatgtga cagagtgctc acactcaggc acttgcctct 1995 ctcctgtcct ggagcccttg ttacaaaagt actcacagct ttccttcact tagttatttg 2055 agtgtgggag aggagaccag gtcacccgat tcccgccaag ccggaagtcc ctgcagcacc 2115 acctttggct aggagggagg ggtgacagcc aaaaagggct tcgggggagt ggttaccctg 2175 ctccctgccc agtgacaagc cctcctttcc cctgggggcc ctcctttccc ctgctccctg 2235 cccagctacg gggccctcct ttcagccttg accccttcct ggttgctacc actcaggctg 2295 ccactcagtg gactccaccc cagggacacg gcagggtctg cagacctccc catgctagat 2355 cagccgtatt tcatgctctg tctgcccagg ctgtgtagat tctgtgtgac ttagtctctt 2415 gtgctgagtg tttgcttgga tcttgaaaac atctttggtt tgatttcttt aacagaggtg 2475 agactattca gactttgttt atttttgtgt taattttggt aaatatggtt tcagtgagtt 2535 tcctcatttc atccaagttg tgcaatgtat cagc ataaag ttcctcttat tttcagtatc 2595 tttaggatcc gtaataatgt cccctctttt attcttgacc tggtgttctt catcattctt 2655 gctatggatt tatcaatttt gttcctcttt tccaaaagcc ccaggttttg gcttcactgg 2715 atttgctgtt tgtcttctgt ctcatgggtc tctgcgccct gcacttcgta ctttccgaga 2775 gtttaactgg tgcttagaga gaaatgcatc acttccaaac ccatgtatta gagaagaagg 2835 gcgtgaaatt tatcacctaa gctttccatt caggaagcta gaaaaggtgt cagtgacctg 2895 ttgcggccca gcggctggag cagcagacgt ttgccatttc tcacgcctga gggcaggcgt 2955 tggagcagct cagccggcgt tgctggtcag ggtctcccgt gaggctggag tcagccgtgg 3015 gttgagctgc tctcctctga aggtttaact gggcttgggg ctcagcttcc aaggtgctca 3075 cctggttgtt gatcagagag cgtgtccgtt gtgatcccag tcctttgaaa ctgtgaagcc 3135 tcgccccgcg gcctgccgca ggatatgttt tggtaaatgt agactgtgca cttgagaaga 3195 atgtattttg agttgttggg tacattgttt tgtgtgtgtc aggtgacatt gactaatcct 3255 gttgctcaga gctcctgtac ccttactgac tgacttaagc ctggtttctc agttactgag 3315 agaggcctgt gaacagttct agctatgatc atgaacatgt gttttcttct tagttatgtg 3375 agtttttgct atacgtgttt tggggctatt ttgtcagatg cctacaaatt taggattgtt 3435 ttatcttcct gtcgaactga ccttgtcatt attatgaact atttctcttc gcctctcctt 3495 ttcacttctt gccttctgtg gattttgtct gatactaatc caggcacact gctgctgttt 3555 tggtcagcgt tttcataatg catcttcttc cctccttcta ctgtactgga tttaaagcgc 3615 accttataga gacatcatat actcgggact ccttttcttt ctctagctgc cagttctgtg 3675 tttcagttac agtgtttggc cctcacattt aaggtgcgtg tgcgtacggc ggattccgtg 3735 cccatctcat gtttttattc cctttattct tcttttgctg ctttctgata gtgatcaatt 3795 tttttattta tatctcttgt attagagttt tagtaatatc ttttaatatt attctcttgg 3855 gtgttgcctt agagatttca tacatgccct tgagttcatt agcatttcct gaatgagcca 3915 atgaccctga gaaggtccct cccatctgcc agttccctgc ccttgatgct gttgctctcg 3975 tccgcctccc ttccacaggt aagcacgcaa gacacaggta ccgtgtgccc caacggtgtc 4035 ttgactcgct gttcctagac atcagtgttt gcttcacttt acccatcccg atgctcttcc 4095 ttcctgcagc ttcatgctcc aatgagggct gattttcatt tagctaaata actttttttt 4155 aagtatttct ttgtatcatg gttatgcttt gactggccgt aagttctctc agcttttgtt 4215 tgtctgaaaa taaatttagt tcgcctttat tctgcacagg acag aattct aggtggatga 4275 tttttgccat tcccagaact ttaaagatgg gctccactgt cttctggctc ccatgtgttt 4335 tgttaaaaat tcagtgttca ggccgggtgc tgtggctcac gcctgtaatc ccagcacttt 4395 gggaggccga ggcgagtgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg 4455 tgaaaccccg tctctactaa aaaatacaaa aaattagccg ggcgtggtgg caggcacctg 4515 tagtcgcagc tactcaggag gctgaggcgg gagaatggcg tgaacccagg agacggagct 4575 tgcagtgagc cgagatcgcg ccactgcact ccagcctggg cgacagagcg agactccgtc 4635 tcaaaaaaaa aaaaaaaaag attcaatgtt cattgttatt tgttgctcct ttgaaggtaa 4695 tgtgtctttt ttctttgtct taaaattgtt tctccttatc tttggttttc agcagtctgt 4755 gctgtgcctg gatgtgattt tctttttacg tatttttctt ggaatataca gaactcaaat 4815 ctgggagtta gcatctttca tcagttttgg aaaattctta gccatttttt ttttttttac 4875 tattttttcc cctgttctcc ctcttctccc tgagacttca gttttgtgtg tgtgtgcaca 4935 tgtatgtatg cattcgtgcg tacgagtgtg tgcatgtgtg cgcccgtgtg tatgtgcata 4995 tgtgagtgtg tgtggctgta acctgcacgt ctcttctgtc atgtgttcta tttttcattc 5055 ctctctgtac atcaggctag atgcctcctg tctacgtggt tttagattt a cgaatcctgt 5115 cttctgttgt gtcccacaga aaaacccatg aggtttttta acattaaaaa cagcagcttt 5175 atgatagaga aaaaaacaca aacatagacg attgtaccat tgcactcaga agaaacatcc 5235 caggccctga gcagcgtgtc tttcctcggc cgagtcaggc ttcctggtga gcctcaggga 5295 gtgcatggtc tcagatgcca tccttctctt ctccagcatt tccactcacc tccgtgttct 5355 tggggagtgc gtggtgtcag atcccatcct gctcctctcc agagtttccg gtcacctccg 5415 tgttctcagg gagtgcgtgg tcttggatgc catcctgctc atctccagca tttcctctca 5475 cctccgtgtt ctcggggagt gcgtggtgtc agatcccatc ctgctcatct ccagcatttc 5535 ctctcacctc tgtgttctcg gggagtgcgt ggtgtcagat cccatcctgc tcctctccag 5595 catttcctct cacctccgtg ttctcgggga gtgcgtggtg tcagatccca tcctgctcct 5655 ctccagagtt tcctctcacc tccgtgttct cggggagtgc gtggtctcag atcccatcct 5715 gctcctctcc agagtttcct ctcacctccg tgttctcagg gagtgcgtgg tcttggatgc 5775 catcctgctc atctccagca tttcctctca cctccgtgtt ctcggggagt gcgtggtgtc 5835 agatcccatc ctgctcctct ccagcatttc ctctcacctc cgagctctcg gggagtgcgt 5895 ggtctcagat cccatcctgc tcctctccag agtttcctct cacctccgtg ttct cgttct 5955 catctctgcc ggaattccac atctgctcgt gcatgccatc caccttttcc actagatcct 6015 tttacatcat cattataatg attttttttt aataagtgtt ttctttcagt tttaaatttc 6075 agatgttgtg tttttcaggt ctaaggtgtc tggtaatttt ttgtggatgc cgattctctg 6135 ttgaaattct ccatcttttc atttccttta tatctctttt cttctttttt ctataatata 6195 ttacattttt ctaataagtt tttagtgagt gtccagcatt gtataagttg acccttgaac 6255 aagagtttga attataaggg tccacttata agtggatttt taaaaaaata tatattgcaa 6315 aaatttttgg aaatttgcaa caatttgaaa aactttgcag atgagccaca tagcctagaa 6375 atatctg 6382 <210> 14 <211> 6309 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2196) .. (2969) <400> 14 ccgtgctgtt cagcagggat ttggaagtag ggggacagtt aatgacaggc atggtggcca 60 catacaggat ggaaaaagca ggaaggtggc tgtgggtctc gaaggtctct ggcttggctg 120 ccaggcagag gcgggcaggt gaccacagga gaggcctggg ctgctgtcag gggagacatc 180 tgtgctgccg tggcacccag cagccgggag gacaggtggt tggtgcccag atgcacccag 240 cctacttaca ggacaaaagc cagtcagaaa acgtgggcat ggtggggacc gctaagagga 300 aaccatgtgg agtttataga gcaatgtcaa aatcgtaatt tacaggtgaa agcagtatgg 360 gcataatttt ttgttaactg aagaaaattg aacagttgga gaagagactc tttcttacac 420 tttcatggag aagaccaaag ttaacaaagt ttcggggcca aatgacagtc ccagggagga 480 gagggaagcc cttggtcccc ctacccctgt cccgtaagca tttagctccc cttggggaca 540 gagctgaccc taagcgtgac agtcctcact gctgggtgcc acacctgtgg gctctcttgc 600 tctccatttg tcagatggag gctgtgtgta tgtgtgtgcg tgcatgtgtg tgtgtgtgca 660 ggtatgcatg tgtgtatgtg catgcatgta tgtgtgcgca cacatgcttg tatgcatgtt 720 tgtacacgtg tgtacatgtg tgtgcactgt gcttgcaagt gtgcatgcat cgtgttgtgc 780 atgtgtgagc atgtatgcac gtgtgtgcat gcatgtgtgc acgtgtgctt gtatgcatgt 840 ttctacacgt g tgtgcatgt gtgcacactg cttgcaggtg tgcatcatgt gcatggtgtg 900 catgtgtgtg cgagcatgta tgcacgtgtg tgcacacgca ggtctgtatg catgtgtgca 960 tgcatgtatg cgtgtgcgtg cgtgtgtgtg tgtgtgcatg ctgcagcatg gggctggact 1020 ggtgcagtag ggaggtagtc acggtcaagg tgggaaatgg gaggaaagac cagaaaagat 1080 taaagttaac gcagcctttc tctgtgcata gaacatcctg aagagggtag aagagaggtc 1140 tgagcgggag tgcactgctt tggatgctca caaggagctg gaaatggtgg tgaaggcatg 1200 caacgagggc gtcaggaaaa tgagccgcac ggaacagatg atcagcattc agaagaagat 1260 ggagttcaag atcaaggtga accggtggga ttggtgtgag cctgtgccca tgcacaggcc 1320 cctggccccg ccccagaggc acagatcacc gcgcctggct ggccttgctt aggtccttgg 1380 tcactggcca cacttaggat cccctctgcc ccctgacctc cccagctgaa gccaccccgc 1440 ctgccaccag gcgtcagaca ccaccacggt ggtccggatc tgtctcctgg gagacgggag 1500 tgcggggcta gtgtgcggcc cagacccacg cagggtgtgg accctgctct cacctgcccg 1560 ctgcgtggcc ttgagcagtc agtttacatg gaggatgtgg ggggtgctgc tccagggatt 1620 ctcaaaccag gaggatttgg aagttaccag cttcccccaa acttcacaga aaacttcagg 1680 cattcgtgaa ccctcagg tc gcctgggccc gactttctgg gaacttggcc acatcagcac 1740 gctgtgccca cagacggtcc ctgaggccag gcttggtttg ggagctgagc cccactagag 1800 gaggcagagg cggtcttctg ggcgtcccat gtagctccac acggtgctga ccgatggctg 1860 ccaggcgcct gcccctgagt tgcatcgtct gccaggcggc cgttcagctg caggcctggc 1920 ctccttgccc cgcgggtccc attctttcct ctctactgtg aactcagccc cttctctgat 1980 tctgcatccc acaggcagag cttggtgggg gcaatgatga cagacactag ctgccacact 2040 cacaggcaca cacacggtat ccacacagca gtgcacacat gtaaacagca gtgtacatgc 2100 acacaagcac gtgcacataa ctttaagctc acatgtgggt acacaacaca gtccatacac 2160 atagaagtcc acatgcacag cacacacacg catag cac act cat gcc cac agg 2213 His Thr His Ala His Arg 1 5 ggt gca tgt tca cac aca cac aca cag ccc tgc cat ctc tct Gca tGc Gc tc Gc Gc tc Gc tc Gc tc Gc tc Gc tc Gc g Pro Cys His Leu Ser Ala Ser 10 15 20 gtc cag aac tcg gcc ttt ccc ccc aac ttg tgc ctc atg tgt cgg ggc 2309 Val Gln Asn Ser Ala Phe Pro Pro Asn Leu Cys Leu Met Cys Arg Gly 25 30 35 cct ggg cag gtg tca ggg aat gtg aca gac gca gcc ctg ggg gca tgt 2357 Pr o Gly Gln Val Ser Gly Asn Val Thr Asp Ala Ala Les Gly Ala Cys 40 45 50 cct ggg gag gga cat tgt ggg cac agc ctg cct gat gcc ctt tcc ccg 2405 Pro Gly Glu Gly His Cys Gly His Ser Leu Pro Asp Ala Leu Ser Pro 55 60 65 70 ctg cag tcg gtg ccc atc atc tcc cac tcc cgc tgg ctg ctg aag cag 2453 Leu Gln Ser Val Pro Ile Ile Ser His Ser Arg Trp Leu Leu Lys Gln 75 80 85 ggt gag ctg cag cag atg tca ggc ccc aag acc tcc cgg acc ctg agg 2501 Gly Glu Leu Gln Gln Met Ser Gly Pro Lys Thr Ser Arg Thr Leu Arg 90 95 100 acc aag aag ctc ttc cac gaa att tac ctc ttc ctg ttc aac gac ctg 2549 Thr Lys Lys Leu Phe His Glu Ile Tyr Leu Phe Leu Phe Asn Asp Leu 105 110 115 ctg gtg atc tgc cgg cag att cca gga gac aag tac cag gta ttt gac 2597 Leu Val Ile Cys Arg Gln Ile Pro Gly Asp Lys Tyr Gln Val Phe Asp 120 125 130 tca gct ccg cgg gga ctg ctg cgt gtg gag gag ctg gag gac cag ggc 2645 Ser Ala Pro Arg Gly Leu Leu Arg Val Glu Glu Leu Glu Asp Gln Gly 135 140 145 150 cag acg ctg gcc aac gtg ttc atg ctg cg aac gca gat 2693 Gln Thr Leu Ala Asn Val Phe Ile Leu Arg Leu Leu Glu Asn Ala Asp 155 160 165 gac cgg gag gcc acc tac atg cta aag gcg tcc tct cag agt gag atg 2741 Asp Arg Glu Ala Thr Tyr Met Leu Lys Ala Ser Ser Gln Ser Glu Met 170 175 180 aag cgt tgg atg acc tca ctg gcc ccc aac agg agg acc aag ttt gtt 2789 Lys Arg Trp Met Thr Ser Leu Ala Pro Asn Arg Arg Thr Lys Phe Val 185 190 195 tcg ttc aca tcc cgg ctg ctg ggt aag tca ccg gtg ggt aag ggg gcg 2837 Ser Phe Thr Ser Arg Leu Leu Gly Lys Ser Pro Val Gly Lys Gly Ala 200 205 210 cca ttt gtc ctt ggg ctg gcc ctg ccg gat gcc gca ggt gca cgg tgt 2885 Pro Phe Val Leu Gly Leu Ala Leu Pro Asp Ala Ala Gly Ala Arg Cys 215 220 225 230 gcc ctg cct gga ggg aag ccc tcc ctg agc tgg tgg tct cag agg cct 2933 Ala Leu Pro Gly Gly Lys Pro Ser Leu Ser Trp Trp Ser Gln Arg Pro 235 240 245 gca cgg gcc tcc agg ggc tgc ttc cta ctg gaa act tagtaccggc 2979 Ala Arg Ala Ser Arg Gly Cys Phe Leu Leu Glu Thr 250 255 caataacctg gcatggccac actgtgtgtgaa tgctggatgg gccttaagtg acaggtacca 3039 caaagtcacc aggaagaatt tggaccaaac ttcactgctg ttttaggttt gccagttgtc 3099 cgaaaagctt aactagaaaa aagccaggtg cagtggctca tgcctgtaat ctcagaattt 3159 tgggaggccg aggcgggtgg atcacctgag gtcaggagct cgagacaagc ctggccaaca 3219 tagcaaaacc ccgtctctac taaaaatacg aaatagccag gtgtggtgcg tgcctgtaat 3279 cctaactact tggaagctga ggcatgagaa ttccttgaac ctggcatgtg gaggttgcag 3339 tgagctgaga ttgcactgca ctccagcctg gtgacagagg gagactctgt ctcaaaaaga 3399 aaacacaagt tcagctgcct tatggagaag ctgctaaccc tgaccatgtg aaccctgtcc 3459 tgaccacccc aaaccacacc cagggccata tcccaggtac aaaaagttcc ttctgaagtt 3519 taaactaagg ccccctcaca gcctttatgc atgtatttct tcccagaact cctggctatg 3579 ttaataacgt tttctatgga aacaaatcct cctcttcctc agacgagccc ttctccagtt 3639 gctgtgggag ttttcctatt ctaggcaggg ctcagctgcg ggcttggtgg gagtgtgcag 3699 gtgggtagtg cggtggtggg gatgtgcccg tgcctcttgt ccctcagact gcccccaggt 3759 ccagtgcgtg cacccatacg tggctcagca gccagacgag ctgacgctgg agctcgccga 3819 catcctcaac atcctggaca agactgacga cggtgaggcc cagggacctc ccctcggggc 3879 ccccagggga acttgcccca caagggatga cggggagggg gagaagcaga tgccaccact 3939 gtctgacagg ctggtgtcct gccatgtctc ttgctccctg agacattctg cttggacact 3999 gcccatgctg gcttcactgg cctctcttca gtgtaaagga ggaattgttt ccagtgcctc 4059 cctgtcctcc cctagagccg ggagacccca cctttcctcc ttcgcagtgg gcccagccca 4119 agcgggtggc ttcgtgtccc cctcccctgg ccctggcctc agcaccccca tcacagtggg 4179 agggagaaca accaggaaca tcctaagcct gacctgaccc agacctgacc ctgacctgac 4239 ccagacctgt acttgcagct tcaggtaaag cctgtgactg ccaggctcgg tgccccatgt 4299 gggccaagaa gccgccccca gctcctggcc acccctgctg ctgtcatcag taccaagcga 4359 agttcctccc agcccctgta gaattgaaca ctgaccgcct ttcccttttc aaatcacatc 4419 tgtgtgtcta cagtaattgc tcctgatcca aatccccaaa gtatacaact gcatcttccc 4479 tgcttcctct cctcctgccg ggtcctggta gaaggcctca ggctgtgacc tccaggggag 4539 gccttctcca gggagtccct cttgtgggct gttcccaaag gcccaggggc tctcctgccc 4599 tcttcccatg gaatataact agcctgctcc cctcccaaat gagacctgca gagggcatgc 4659 cccaggcctc ttagctccca ggttgggata tgctacagat cggccacaaa ctctgagcaa 4719 agacc tggtg atctctaggg gaggggagag gtggagaaac agcgcaggga gaagccagtt 4779 gacgctgaga ctactcgtgc tgccagttcc tgatgcaccc tctccactga ccacaccagc 4839 cctcaggagg ccaggcctgg gaggatcggc cccgcaagag gctaatgaca cagtccaggc 4899 cagctaacca catgctcggc tgccaccccc accagcccct tgaatgacac agtccacgcc 4959 agctaaccac gtgctcggct gccaccccca ccagcccctt gaatgcctcc agctttttgg 5019 agtggccctt ggggtctcct gggctcgtgt agggcagcat agaattgctg agggtcccag 5079 agtgggttcc aaagtcaacg tggaactgcg tggcacggag caggccttgt tccgtgcagg 5139 tgctcatgca cctcccagct tatgggggtg actccagtct gagcatctcg gcagaggtgt 5199 gcagagccgc tgccttttgg gaaaggccag ctggacccct agtgtcccgc cacagatggg 5259 ggccctggcc aggagggagc ctctgtgcag cctgtgccct gcaggagcac tgaccttctc 5319 tccctcccct ccctgcacag ggtggatctt tggcgagcgt ctgcacgacc aggagagagg 5379 ctggttcccc agctccatga ctgaggagat cttgaatccc aagatccggt cccagaacct 5439 caaggaatgt ttccgtgtcc acaagatgga tgaccctcag cgcagccaga acaaggaccg 5499 caggaagctg ggcagccgga atcggcaatg acccccaccc agggggccag cgggagcagg 5559 gcctgcatga gaccccgaca gaaggtgggg gggggggcct ctgggaagca caggccagca 5619 cctccccagg tggcaggatc tggcttgggg tgcccggccc tcatccctgc ccacgcagtg 5679 agtgctcatg tgtcttggcc ccttgcttgc aaactggata aagggtgccc aagcctctcc 5739 tgatgcattt gtaaacaaga aggtttcagc agtattacac cacctccctc atgcctccga 5799 gggggtggaa gggggtgggc acactccagg gccccccatg cccctggccc ccagggactg 5859 gaagaggctc ccaacccaga gtgtccctgt gggaggcagg cagaaggtga caattgacac 5919 gatttcctgc acgcgtcctc ctctaccttg gaagcagtta gaatctacca ggcacagatg 5979 aggccgccct tgcctgacgg agcttgatga gcagcccttg gtctccggtt ccaggactga 6039 gagcccagct gcctctgccc acccttcccc aggcctctgc cagcctctgg ctgcacggtc 6099 aggccctgcc ccatggcagg cctgccagag cttggctggg gacccctccc gcctctggct 6159 ccctgatggg ctggatgtaa cttgtgtctt ctagccgctt aaggagccca ggtgttttaa 6219 ggaatgaatt ggtcactgca tcttgtatcg attatggttc tgagaaaagc aaatatcact 6279 tttggctgca ttaaaagaag catcatatat 6309 <210> 15 <211> 6645 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1159) <400> 15 a tcg gtc tct gga cgc tgc gcg gcg ctc cta gga gca ggc gtt ccc gac 49 Ser Val Ser Gly Arg Cys Ala Ala Leu Leu Gly Ala Gly Val Pro Asp 1 5 10 15 tcc ggc aag agg gtg gcg cct gga ctc tcg ccc tca gag gga ggc ccg 97 Ser Gly Lys Arg Val Ala Pro Gly Leu Ser Pro Ser Glu Gly Gly Pro 20 25 30 tcc cac ggt ctg tgg cta cgg atc cca gga ccc tct tcg cgg gcg att 145 Ser His Gly Leu Trp Leu Arg Ile Pro Gly Pro Ser Ser Arg Ala Ile 35 40 45 cgc gta gcc tca ggt aac tgc atc ctg ccc agc atg acg gcc ccc tgc 193 Arg Val Ala Ser Gly Asn Cys Ile Leu Pro Ser Met Thr Ala Pro Cys 50 55 60 ccg ccg cca cct cca gac ccc cag ttt gtc ctc cga ggc acc cag tca 241 Pro Pro Pro Pro Pro Asp Pro Gln Phe Val Leu Arg Gly Thr Gln Ser 65 70 75 80 ccg gtg cat gcg ctg cac ttc tgc gaa gga gcc cag gct cag ggg cgc 289 Pro Val His Ala Leu His Phe Cys Glu Gly Ala Gln Ala Gln Gly Arg 85 90 95 ccg ctc ctc ttc tca ggg tct cag agt ggc ctg gta cac atc tgg agc 337 Pro Leu Leu Phe Ser Gly Ser Gln Ser Gly Leu Val His Ile Trp Ser 100 105 1 10 ctg cag acg cgg aga gcg gtt acc acc ctg gat ggc cac ggc ggc cag 385 Leu Gln Thr Arg Arg Ala Val Thr Thr Leu Asp Gly His Gly Gly Gln 115 120 125 tgt gtg acc tgg ctg cag acg ctg ccc cag ggg cg cag ctc ctc agt 433 Cys Val Thr Trp Leu Gln Thr Leu Pro Gln Gly Arg Gln Leu Leu Ser 130 135 140 cag ggc cgg gac ctg aag ctg tgc ctg tgg gac ctc gcg gag ggc agg 481 Gln Gly Arg Asp Leu Lys Leu Cys Asp Leu Ala Glu Gly Arg 145 150 155 160 agc gct gtc gtg gac tcc gtg tgc ttg gag agt gtg ggc ttc tgc cgg 529 Ser Ala Val Val Asp Ser Val Cys Leu Glu Ser Val Gly Phe Cys Arg 165 170 175 agcgcg gcc ggg ggc cag cca cgc tgg acg ctt gcc gtg cca 577 Ser Ser Ile Leu Ala Gla Gly Gly Gln Pro Arg Trp Thr Leu Ala Val Pro 180 185 190 ggg agg ggc agc gac gag gtt cag att ctg gag atg ccc tcc aag acg 625 Gly Arg Gly Ser Asp Glu Val Gln Ile Leu Glu Met Pro Ser Lys Thr 195 200 205 tca gtg tgc gcc ctg aag ccg aag gca gat gcc aag ctg ggc atg ccc 673 Ser Val Cys Ala Leu Lys Pro Lys Ala Asp Ala Lys Leu Gly MetPro 210 215 220 atg tgc ctg cgg ctg tgg cag gcc gac tgc agc tcc cgc cca ctc ctt 721 Met Cys Leu Arg Leu Trp Gln Ala Asp Cys Ser Ser Arg Pro Leu Leu 225 230 235 240 ctg gcc ggc tat gc ggt g tg gtc ctg tgg gac gtc tct gag 769 Leu Ala Gly Tyr Glu Asp Gly Ser Val Val Leu Trp Asp Val Ser Glu 245 250 255 cag aag gtg tgc agc cgc atc gcc tgc cat gag gag ccc gtc atg gac 817 Gln Lys Val Cys Ar Ile Ala Cys His Glu Glu Pro Val Met Asp 260 265 270 ctt gac ttt gac tcc cag aag gcc agg ggc atc tca ggc tcc gcg ggg 865 Leu Asp Phe Asp Ser Gln Lys Ala Arg Gly Ile Ser Gly Ser Ala Gly 275 280 285 aag gcg ctg gct gtc tgg agc ctg gac tgg cag cag gcc ctg cag gtg 913 Lys Ala Leu Ala Val Trp Ser Leu Asp Trp Gln Gln Ala Leu Gln Val 290 295 300 cgt ggg act cat gaa ctc acc aat ccc ggg atc ggag atc 961 Arg Gly Thr His Glu Leu Thr Asn Pro Gly Ile Ala Glu Val Thr Ile 305 310 315 320 cgg cca gat cgc aag atc ctg gcc acc gca ggc tgg gac cac cgc atc 1009 Arg Pro Asp Arg Lys Ile Leu Ala Thr Ala Gly Trp Asp His Arg Ile 325 330 335 cgc gtg ttc cac tgg cgg acg atg cag cca ctg gcc gtg ctg gcc ttc 1057 Arg Val Phe His Trp Arg Thr Met Gln Pro Leu Ala Val Leu Ala Phe 340 345 350 cac agc gcc gct gtc tgc gtg gcc ttc acc gcc gat ggc ttg ctg 1105 His Ser Ala Ala Val Gln Cys Val Ala Phe Thr Ala Asp Gly Leu Leu 355 360 365 gcc gcg ggc tcc aag gat cag cgg atc agc ctc tgg tca ctc tac cca 1153 Ser Lys Asp Gln Arg Ile Ser Leu Trp Ser Leu Tyr Pro 370 375 380 cgc gca tgactcaccc actcccttcc cgggagacga ggagggcggg cagggaggtg 1209 Arg Ala 385 ggcatcaggc cccagccttg gcctgaaacc tcaagggcct ctgaggacca gcaagtcatg 1269 gcccaaggac catggagtcc ccgctgtctt catgaggttg gtatttcctt ttgtggagtg 1329 cctcatcaca ggacggtgac tctgggggcc agccagagcc ctggccgtcc gaggcctgca 1389 ggagacgttg gcttgggcct gctgtgttgc cagctgaggg tattttataa taaatttcca 1449 ttgccaagtt gcaggcttga ggtgggagct ccctgaggag gctctggggtcc cccacttagc 1509 atcagtgccc tcagaccccc accaggcagg atgctcagcc ccacctgac gtcgt gtc gtcgt gcctgcc ttcctg ggccaggcct caggagatga taggccccaa 1629 ccatagctgc gtcgatgtcc acatgacccc tcaccccgag gaggccagga gctcccaaca 1689 cacaggttga ggccaggatc aggatcagga agtaactgaa ctccctaaag agtgaagcag 1749 agaaaggtgc ctgtgaggga cggcaagggg ggcttgcagc gcacagggcc aggccagatg 1809 tgggatccgg gagggcacgc ctgcccgcag agggtgcagt ggggaaggcg cacagggtgc 1869 acctccaggt gagtgctggg cagaaggcac gagagcagca agggagtgtg acaagcaccg 1929 cctcacagtg gccaaggcca cagtcacagc tgcggctgca cacagggtgg cccccagggc 1989 acaacacagc aagagcagga cttagcagcc agagcctcac actgcatgca gccgggccca 2049 gcctggccgg tcgtctcctc ctaaaagcgg gtgttgattg ggaaagaacc atgaccccga 2109 atattggagt ggggcccatg ggcagatcca gagaagctgg gaccacacac gcctgtgtct 2169 gcccggattg ccggaagagc ccctctagct gaaggcccag ggtggcctcc cttgaggcag 2229 ttgccctgca aggccctgcc gatgctcctt gggaccccca cctgggcttc tagtcctaga 2289 actagactcg agtccagcag acccccagga tgagatacag agggtgaccc tgagagtggc 2349 atcagcctcc tgcaggacca catggcattt ccaggtttcc aggcagaaat ctgaacatgt 2409 gtgggacgga tcggaagggt gtgggatcc a ggtggccgga gcaggggtgg atcaggggag 2469 ttcccggaac agacctgcca aacggagggc tggactgggc gctgcagctt ggggccagga 2529 aggctccagt gccgggctgg gggtgggggc tggattacag cctgagggtg gctgcactga 2589 gtgaagtgga catggccagc cgccgtgggg tacagccgag gagggcttcc aaggcctggg 2649 gatgggggtg ttggatttgt cagtgagacc tgtgcaccca ctgcaggggg tcccaaggcc 2709 gtgcctcccc aaccccactg tgaggaacat ggttgctggg gggcccggag tccttgagga 2769 gtcctgtgac cacacttctc tgttggtcag aggtaccatg gggaccgttc catcaaacgg 2829 gaatgtcagt gctggccggg aaagcggccc ctggcccaag cttggagacc acctggctcg 2889 ggtactggcc tggctccgtt ggacaagggt ggccaccagg tgcccaggac ctttggagag 2949 gggggccctg ctgcttttcc tcgagtgtcc tatagccgcc aggatgcgta gggcactccg 3009 ggaggtattt tcatatcact gaggtgtcag ggaggggaag ggtcctgggt ttaggctgca 3069 gtgactgcag gtgctgaggg agctgtgccc tgggtgctca tcacaggctg tcacagtgag 3129 ggaaggtgtc aggttctgac atccccatga cagcggcagg gtaggtggag tgggaattgg 3189 ctttgcagtt tccctgcatg cccttgacag ccttgccaaa ggcacatctg ccccgcctca 3249 gctcccaccc tgagggttct gggcctctac ccct tcccct gtttatgtcc ctgtcatctt 3309 tggcatcatc actgtagtta caaaactccc tacgtcccac agccacgagg tgggtatccc 3369 acatgagggc ccaggtgtgc atgccagcat gaggttggcg agtggcactg cctgctgatg 3429 tcttacatag aggccatgaa gagctgtggg cagggtgtac agaccctgag ttggcccctg 3489 gccctcgtgc tttcagtcaa aggcacaagc agggtggatg gcaggcggct gccccctagc 3549 ctggccttga gctccctgcc ccaggccatg tggcgttgag cagtgtccag gcacatcttg 3609 ttctgaatct cagtgtgcag ggatggagtc gggacagcgt gagtcctgca tgcctaacac 3669 agccctcacc cctccagtgc acaacggggc cacgtgcccg catctgggtg gctaggcaga 3729 tagggccccc cttgccaggc agatccagct tctgaggcct tatagacgtc ctgtggaggg 3789 caggcccagg actttcattc acctggctga gctgcctggg agagcagcag aaccggtgct 3849 ggggtccaag ccggccaaga gcagtgcagc cctcctggtc ctgttcctct cttgagctgc 3909 tccgtggtgt ccacagcaga gccatgtggc tctggacagg tcggcctttg tgtcaacaga 3969 acctgggtcg tgatgaatca ccatgcgtct gaccagcctt gaaaccccca caacagaaga 4029 agaaacaggg tctcagctcc agacatccag cttggaaaag atgcacctga acattggcgt 4089 tctcttccta gcaaacagcc acttcctgta ggctggcag g aacgccaaca gagccagcag 4149 tgaaggcatt aagtggggag gaggggtggc ccggaggcag cacgcgaagg tcagcatgca 4209 gctcctggga tgaacctgag aggcgactcc tggcagcatg gctggtcgct gccatcacgc 4269 ccctggccaa cccaccaact gggagaggca gcccttccac atcttcctcc ataatgctct 4329 tgggtagcag tgaggcctct caagccagag agaacttggt gtttggaaac aacggcggac 4389 atttcttgcc attttcagtg ccaactcagg taggtgtgtt ctaccatcct gtgtttttgg 4449 ggtgtttttt tttttgagtc agagtctcac tctgtccccc aggctggagt gcaatggagc 4509 agtctcggct cactgcaacc tctgattccc aggttcaagc gattctcctg cctcagcctc 4569 ccgagaagct caggaccacc cacataggtg caggccatca tgcccagcta attttttatt 4629 tttttttatg gagaaggagt ctcgctatgt tgcccaggct ggtttcgaac tcctgggctc 4689 aagcgatcga tcctcccgcc tctagcctcc caaagcacta gaattatagg cctgagccac 4749 tgcgcccggc ccaccatcct gttcttattg gaagaatttc catgtgtcga ggcacgggca 4809 caacgtagct ggtcctctgc tcagggcccc acaaggctgc gtcagggtgg cagcgcggct 4869 gggggctttt tctgttcaaa tccagattct cgtggctgtg agccccagcc ctgggcactg 4929 tccgcctggt ggtgtcttca cagccagcag gggtggcctt gggg tgttct gtggagtaac 4989 tttcacggcc cagagtggga tcctgagtgg ctggagccgt atgctccagc atccccagcc 5049 gctgcctccg gtgcaggtgg agtgggcccc tctgattacc aggagctgtc agaggggcag 5109 caggtcccac tccactggcc ggtgggcagc tgtgtgcagg gacgcgggtc ctggcacgtc 5169 tgcctggtga ggccctgcct ccagtgccaa ggggcctccc ctctcgacgg tgggcgccac 5229 catgtgctga cctctgtgca gccccacttt acaaggtagg ttcggccagc accccatccg 5289 cgggcgggca gcactcaccc agcgttgcgc cgccaacagg gtccctctta gacaagcagc 5349 tgtgcctaga gccttttcct tcctccctgc gtgttacctg caggccaaca gacggccctg 5409 ggtctgggac caggagaacc tgcctccgcc tctggcagtg ggtgtccctg caggcagatt 5469 gggcttggca cgtagacacc gaggggtcag ccgatgccgg gagatgatcc cgggaagggc 5529 tccggagcac agcccaggac ccgccgccgc tgctgggcgc tccatgttga cgtgctgtgc 5589 gtgtctccac tccccaggca atgatgttca atcaggtgtt tcccacctgt gtctctgcca 5649 agaagccaca gaacaccctc tgcacaaaag gagtgtttgc acaaagaaaa acaaccctcc 5709 gggggttctt tagaaatgct tatactcaat tagctagaac ttcatgtgaa atcccagcgt 5769 ggaagacaac aagccggcac cggtgaaaac tttgctgtgc acctgccct c taccaagccg 5829 ccagccccac cagccctgtg gtcctaggtg ggcacagctg ctgcacggtc ccccaggcct 5889 gcctctcctc ggggtctcaa ccttcatacc agatttgcca gcatccccat tcccgccttg 5949 tgggtggaga gtccttgaga ccctctgtca ctctgtcagc ttccccaggt cagcgagctg 6009 tggcttggct cccacgcatc agcttttatg ggaggcccat taggagctgg gcaggaggga 6069 cagaggggag gccaggcagc cactgctgag tgggacgggt agcccagccc atgaggctgg 6129 ccagccctac aggggaggtc ccacagcact ggccgggaag tccacatagg aaagcatcag 6189 ttgagggatg aagccatgga cgatggggac aacggccaca gggtgtgcta agctgaggaa 6249 attagtagga ggtgctcata agctgttttg ttttttggtt tgtttgtttt ttcttttaag 6309 agaccaggga cagtgggggt ctcgctctgt cacccaggct ggagtgcagt ggcatgatcg 6369 tggcttactg cagcctccaa ctaataggct caggtgatcc tcctgcctca gcctcccgag 6429 taactcatgg cctttaagtg aactgcttcc accatccagc tgtgcaggtg gcctgggaac 6489 agcagcacat ctgtcccctg ccacctcttg catgcacact tgacctcctg acttgggctc 6549 tgaaacctgt aaaatgtggg gtgtagagaa atcgagtcat ttggcctcat cctggtgcca 6609 ttatctcttg ctacattaat aaaccacctc aaacag 6645 <210> 16 <211> 5879 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1219) .. (1473) <400> 16 ggtagacaca ccacccactc tttcctcatg gtgaaggtgt tagtcatcta tttttcccct 60 gtactagagg tctttcagag ccaatagtcc ctctggcaag agtgaagctt catctctgcc 120 ctggatgata gagtcttagc aaccagaatc agccatgctg gaggagaggt cctttgcatt 180 cattgcacca agtactaggt cgataatggc cctgcctagc aagatacttg gcctcagaaa 240 caagaaaggg gttgatcaga gaaccacagg ccagagggaa gtggagtcat tgcagctcca 300 gagtctgcat ggttcatttt gacactaatc atagactcac agagccccca gacaccctcc 360 aggataaggc tccttaactt tagttgggta actgaccccc ttgagaatct gatgaaagca 420 cgcccggcca tcacttctgt cattttaagg agaaggaaaa ccaaacctaa tagagacact 480 tgctgaaaac actgggagag tcattggcaa agctggactc agaaaccagg cctcctggtg 540 cctggctggg ctcttttcac cacagcactg ctcacccttt ctatagtgtt tccagtcttc 600 tgaccacatt gtgcacttct agtggacaaa gtccagatct ttctttggga atcttttcat 660 tcctagttga gtattctgta ctcagtaggc ccttggtaaa tattaggtga gaaaacaaaa 720 gcgaaatcaa ttcaaacttt ggttttcctc cttggtaatt tagtgcactg ggataaggac 780 cagagaagcc tggggaaggt taatgtgctc ttgccattgg aggctggcac agttttaatt 840 tctccactgg a tgactgttc tgctttccag gggtctcctg gttctccaag ggcattgccc 900 tcccgcagat gagcttgcaa gctaatactg ggttctctct gggctcacat ctaaccttag 960 ctgtggcacc aggtaacagc tgattccaac ttcattgtct ttgtacctgg gaagggggaa 1020 tggatcctgt ggcctgcctc tgctcctctt gggaatgggc aaggagcaga tcccagacaa 1080 gaccctgcag gcaggtaaag gttctggttg ggaatgtatc cagaaggaac taaaataaat 1140 ttgggggttt gcaagcccaa gcctgattat gttaaaaggt tcatgttccc ttcttgggca 1200 atgtccttca gatactaa aga gaa gat aga ggg gta atg ggc aga tgc tgg 1251 Arg Glu Asp Arg Gly Val Met Gly Arg Cys Trp 1 5 10 aaa atg gtt tgg ggc tct cct aca ggc tct gtg acc ttg ggt caa tta 1299 Lys Met Val Trp Gly Ser Pro Thr Gly Ser Val Thr Leu Gly Gln Leu 15 20 25 ctt ccc tgg tct ggg att cca cac tct ctg aca cat cca gga cag tca 1347 Leu Pro Trp Ser Gly Ile Pro His Ser Leu Thr His Pro Gly Gln Ser 30 35 40 atg gcc aag agg ttc tgg atc agg act cta gga ttc tct gat gtc ttc 1395 Met Ala Lys Arg Phe Trp Ile Arg Thr Leu Gly Phe Ser Asp Val Phe 45 50 55 tgt ctt gat gtc tac ata agc tac ttt atg g ga gaa cat ccc ttc tct 1443 Cys Leu Asp Val Tyr Ile Ser Tyr Phe Met Gly Glu His Pro Phe Ser 60 65 70 75 atg ccc cag ctt ccc cat cca tta aaa aaa taattcaagg ctgggcatgg 1493 Met Pro Gln Leu Pro His Pro Leu Lys Lys 80 85 tggctcatgc tggtaatctc agcactttgg gaggccaagg caggagggtc gcttgaaccc 1553 aggagttcga gaccagcctg ggcaacacag cgatacctcg tctctactaa aaacaaagaa 1613 acagacaaaa aaattcaagc ttatatgtat taagtgcttt ctcctctgtg ggtgacattg 1673 tctgggctgg tgctaagcct tgttcttgct gaagcacaca gtatacacct tctcccccag 1733 gacccggctg ctcactaata agaatattcc gcctccccca ggagctatat ggtaccacag 1793 agcatctgtg aggagggggc agtggagatg aagggtgcct gggatgtgag gaaggaggca 1853 aaatctcagg ttgggtgacc atgtagacaa gcagagaggc caagacatct gtgaggctag 1913 ttcagatctc ctggtagtgc tggtactacc gtagaaatgg ggcacagggc ttctcccatc 1973 tcccggcatt gtctgcagga tggcccttct cccacaggcc ttgtcctaac aataatagtg 2033 gtgactgcag tgcattgagt gcttgctcta tgccaggcat tatgctaagt gcctcacaga 2093 acctatcaca tcaaatcatc aggtatccct gtgagatacc cccagtgtag cagtccggaa 2153 a ccgaagctt aggttttgtc acttgccaaa ggccatggag ctagccttta gtcaagtcca 2213 gctcagctct gatgataaag cctttgctct gattgatttt ccattggctc taacaaaaag 2273 aaactggaga tttgattgtg ggtgttgaag ggagtgtagg tatggttttt ctgcttataa 2333 atgtaatatt aatacgtagt catcataaaa tatatttgca gaaatactgt aaaaatgaaa 2393 gccctccata aacatcctat catcccagag ataaccactg ttagagttag cataaatttc 2453 cccagagttc ttttctgtgt acacacttcc ttaaccaaag taagtacata ccatacatgc 2513 tgtgtttcat gcttatttgt ttaacatgtc ccagacagtt tacatgtcag tttattctct 2573 ttaacattgt atggatggac tgtaatttac ttaacagacc ttatcatggt catatggttt 2633 actgccagtt tcccaggcta ccgggaatat ccttgttcct gtatctttga gtatttgtgt 2693 atttctgtag gataaatttt cacaagtaga attgctgagt caaggggaat tttaatggta 2753 ttacaaagtt aagagagatt aagcaccttt tcaaatgtct gtttcccatt cttatattct 2813 tgtgtaaact gcctgctcat agtctgtgtc cattctttgg tcagctggga gatgagtgaa 2873 actcaggggt gaaggctgca cttttgagca tctgcttacc ttgtgatccc atgcccaccc 2933 agccagttct gtctctgtga cctctgggaa ggagcatccc caagaaatat ctgtccagtc 2993 acagacc cag ttagacctgg accagaaagc agacgtgttg aacccctgtg atcgcctagg 3053 actgtgactc acccatacct aggagtatga gatcaaagtc ccaccctgct gttaaccagt 3113 tgggtcacca taaacaagtc tccaagccta gatttcttca tctatacaag gagaggattg 3173 aactgatggc attccacttc tagttctaac actcagagcc aaaaatccat ggaggaagag 3233 gaacctcaca ggcagaaagc tggacatggg gcttcaaggc attgccaagg cagagatact 3293 tacagatgcc aggatcactg caggtgaggg tcccatcttc agggaccagg tgggagttgt 3353 acctctggtt gggcagcacc tctgtcatct cccctgcccg ctgcctctct cccatcttgg 3413 tcttcaggaa aatcccaaaa ccaacatccg ctccatctga cataaactgc cacctgcagg 3473 ggatatcacc aattgagaca taattctgtc tgtgtgtgcc ctctccgggg tcctggcacc 3533 agggcttctc ctattccagc ccacctatca ggacctatag atgaaagctc gggtctcctg 3593 gaagggccca ggcccctacc tgaggacaca gccagggaag aggatctcat actccacttg 3653 gtgggaggag ccacgggaaa tctgcacgct gtgttcatac tgctgtttca cctggtctcg 3713 cacataatac ttcctgggga tgtcaccccc gtagttgatc tagaagcatg gcatggagtg 3773 aactggaatg tgcatttgag ccaggcatcc ctgttcacct ctagcctctg gcggctcata 3833 ccttggattt g cacttgggg tttccatcag ggtcagtcat ggtgccccca tactccacag 3893 gcacctggtc agggctgata tgtttcagta aaacctcctt ccaatttgct ggcaggagag 3953 ggaaggaagg ataaagatgt atctcaacac taggtaagat ttcgccataa ccctagtggt 4013 ctacactaaa gaggcagaaa aaacccatcc attgcacccc acaacacccc gcctcaaatt 4073 cctgcattag gagcacacag tgcatgcata gtactgcagg gggttcagca ggagccagag 4133 gatggctctg ccccaggcca gaaatcgaga ccctggttcc tgccctcgtg tctgaacagc 4193 taagtgacat tcttgccctg cctggttatg gtgggagtga aatgaactaa gtacttgaga 4253 aggcttttct gtttgagaca gagtctcacc ctgttgccta ggctagagta cagtggcgca 4313 atcttggatc gctgcaacct ccgcctcccg ggttcaggtg attcttccgc ctcggcctcc 4373 tgagaagctg ggacaacagg cgcccgacac cacacccagc taattttttg tatttttggt 4433 agagataggg tttcaccgtg ttggccaggc tggtctcgaa ctcctgacct cagatgatcc 4493 acccgcctcg gcctcccaaa gtgctgggat tgcaggcgtg agccactgcg cccggccgag 4553 agggcttttt aaaccataaa gtgccttata cacgttaaga gtatgttatt accccatgga 4613 ggtgatacat tgaagtacag caggagaggg gacaaagaaa gggtagaagg acattccatg 4673 cagaggaaac agcacgt gtg gcgggcagga aggcctgaat gcacataccc tgtcctgatt 4733 agactgaaca ttgtgagggc agaactatgt gtctttcccc caccttcccc tacagctaag 4793 tcgtgactta ataagtaaat gcatctctgt agagtcaccc cttaaatgga ttcttggctt 4853 taccccagcc accatttcac ttctgctccc attgttttca gctgttgagc caccagtaat 4913 ttggctcttt tttttttttt tttaaaatac ccaagctcct tcctgtctag gagagtttga 4973 ctctagcaca gccaatgcta agaaccactt caccaatcca aattcacaaa tatcagccag 5033 gtacaatatt ttgatactaa aacctgccta tgcctactat atagagcata tataggcagc 5093 agctccaggc cctggggtac aagccagtgt catgctggct ggagacccgc agaaactgtc 5153 cagagtctgc cagccctcag atttttaggg accaaagacc atgcaactcc tgggaacaca 5213 gtgtctgtgg tcttggggtg atttaatctg cactgctaag ctccagtgac cagcccgagt 5273 gaatctcccc cctctgttga aaattctgta tcttcccagc ctgaggcagg tttggttgaa 5333 agagttttag gtgtggtagg ggaacagact gaacctccta cacagctctg ctgccaggaa 5393 accaaaccgt ctcatgccca tggtgggtgg tagcagcaga aaaaacaaaa atcataaaaa 5453 cctcttgctc agcttttata gttcttcccc cagtccagct ggagagttgg gataaggcca 5513 ggaggattct tcccatctta c agagagaat aactgaggca acaaaaggca gagagctggc 5573 tgggtgcggt ggctcatgcc tgtaatccca gtgatttggg aggctgaggc gggaggattg 5633 cttgatccca ggagttcaag atcaacctgg gcaacatggt gagctcccgt ctctgccaaa 5693 gataaaaatt taggtgggtg tgctggctgt ggtcccagct gctcaggaga ctgaggtggg 5753 atggtcattt gagcccggga gattgaggct ccagtgagcc gtgatcacgc cactgtactc 5813 cagcctgagc aacagcaagg ctccctcaaa aaagaaaaaa gaatgctttt gtggggacct 5873 aaattt 5879 <210> 17 <211> 5899 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2130) <400> 17 cac ttg gca ccc ctc aac cct ctc tta ttg cgc cag ggt gac ttc tac 48 His Leu Ala Pro Leu Asn Pro Leu Leu Leu Arg Gln Gly Asp Phe Tyr 1 5 10 15 ctc caa gtg gag ccc cag gag gag cag tct gtc tgc atc atg atc aaa 96 Leu Gln Val Glu Pro Gln Glu Glu Gln Ser Val Cys Ile Met Ile Lys 20 25 30 tgc ctc tcc ctg gac ctc tgc aca gtg gac aag aag cct gtt ccc gag 144 Cys Leu Ser Leu Asp Le Cys Thr Val Asp Lys Lys Pro Val Pro Glu 35 40 45 cca gcc tac cct ata ctt ttc acc caa gaa tgg ctg gag gcc atc aac 192 Pro Ala Tyr Pro Ile Leu Phe Thrrl Gln Glu Trp Leu Glu Ala Ile Asn 50 55 60 agt gac ttt gag gga aat ccc cta cac aac tgc ttg gta gca tca gaa 240 Ser Asp Phe Glu Gly Asn Pro Leu His Asn Cys Leu Val Ala Ser Glu 65 70 75 80 aat ggg att gcc cct gtg cct tgg acc aag ata acc agc cca gag ttt 288 Asn Gly Ile Ala Pro Val Pro Trp Thr Lys Ile Thr Ser Pro Glu Phe 85 90 95 gtg gat gac aga ccc caa gta gtg aat gcc ctc tgc caa gcc tgg ggg 336 Val Asp Asp Arg Pro Gln Val Val Asn Ala Leu Cys Gln Ala Trp Gly 100 105 110 ccc ctt cca tta gag gca ctg gat ttg agc agc cct caa gag ttg cac 384 Pro Leu Pro Leu Glu Ala Leu Asp Leu Ser Ser Pro Gln Glu Glu Leu His 115 120 125 cag gcc agc tcc cca gac aac cag gtg ctt cct gcc cag ttg gcc 432 Gln Ala Ser Ser Pro Asp Asn Gln Val Leu Pro Ala Gln Ser Leu Ala 130 135 140 aag ggt aag ggc agg aca tat ggg agc aag tat cca gga ctc atc aag 480 Lys Gly Lys Gly Arg Thr Tyr Gly Ser Lys Tyr Pro Gly Leu Ile Lys 145 150 155 160 gtg gag caa gcc cgg tgt ggg gag gtg gct ttc agg atg gac gag gtg 528 Val Glu Gln Ala Arg Cys Gly Glu Val Ala Phe Arg Met Asp Glu Val 165 170 175 gtc agc cag gac gag gga gac tat gtg gct ctc cta ggc ttt tcc 576 Val Ser Gln Asp Phe Glu Gly Asp Tyr Val Ala Leu Leu Gly Phe Ser 180 185 190 caa gag agc aga gga gag tct ccc agt agg gag gca ggc aca tcc agt Gln Gln Ser Arg Gly Glu Ser Pro Ser Arg Glu Ala Gly Thr Ser Ser 195 200 205 ggg tgt act tct ggg gca cta gag gag ata gct gga act aag gaa act 672 Gly Cys Thr Ser Gly Ala Leu Glu Glu Ile Ala Gly Thr Lys Glu Thr 210 215 220 ccc tta ttt caa aag ata ctg cct ctc tca gag gcc aat gaa gga cct 720 Pro Leu Phe Gln Lys Ile Leu Pro Leu Ser Glu Ala Asn Glu Gly Pro 225 230 235 240 tcc ttg gga aat cgg gct tgc aca aat cca gaa agc tct gag gag agg 768 Ser Leu Gly Asn Arg Ala Cys Thr Asn Pro Glu Ser Ser Glu Glu Arg 245 250 255 ccc tat aat ttg ggc ttc agg aga aag gtc aat ctt aaa gca ccc acc 816 Pro Tyr Asn Leu Gly Phe Arg Arg Lys Val Asn Leu Lys Ala Pro Thr 260 265 270 cac aac tca gaa agg ccg ccc caa ggc tcc tac atg aat gtc ctt gag 864 His Asn Ser Glu Arg Pro Pro Gln Gly Ser Tyr Met Asn Val Leu Glu 275 280 285 285 gac gca ctg gac tgt gcc tct ggt ctc agg gca ggt gtc tca caa gag 912 Asp Ala Leu Asp Cys Ala Ser Gly Leu Arg Ala Gly Val Ser Gln Glu 290 295 300 cca gct gcc tcc aag atg cag gga cct cta gga aac cca gag atat 960 Pro Ala Ala Ser Lys Met Gln Gly Pro Leu Gly Asn Pro Glu Asn Met 305 310 315 320 gtg cag ctc agg cct gga cca aga caa gcc tcc tct ccc cgc ctg tcc 1008 Val Gln Leu Arg Pro Gly Pro Arg Gln Ala Ser S er Pro Arg Leu Ser 325 330 335 cca gct tct cct gca gct gca gcc tct gaa aca aag ata gag gtg aag 1056 Pro Ala Ser Pro Ala Ala Ala Ala Ser Glu Thr Lys Ile Glu Val Lys 340 345 350 acc aaa gag aga aat ggg aga ctt ccc aag ccc atg ccc tgc cct agc 1104 Thr Lys Glu Arg Asn Gly Arg Leu Pro Lys Pro Met Pro Cys Pro Ser 355 360 365 aga aac acc tcc tcc cct gag ccc ccc act cct ggg ctc aaa ttc tca 1152 Arg Asn Thr Ser Ser Pro Glu Pro Pro Thr Pro Gly Leu Lys Phe Ser 370 375 380 ttc ttg aga ggg cag agg caa ccc tct gtg acc ccg gag aaa gcc tca 1200 Phe Leu Arg Gly Gln Arg Gln Pro Ser Val Thr Pro Glu Lys Ala Ser 385 390 395 400 ctc cag cac aat ggg ccc tgg aaa gtc ctg tgt tcc ctc tac tct cct 1248 Leu Gln His Asn Gly Pro Trp Lys Val Leu Cys Ser Leu Tyr Ser Pro 405 410 415 aaa ccc aac cga gcc aaa tct ttg ggg aaa gct gga aca act cag acc 1296 Lys Pro Asn Arg Ala Lys Ser Leu Gly Lys Ala Gly Thr Thr Gln Thr 420 425 430 aaa aca tct ggc cca gcc act gcc ccc agc cca ctg act gag gaa aag 1344 Lys Thr Ser Gly Pro Ala Th r Ala Pro Ser Pro Leu Thr Glu Glu Lys 435 440 445 gct gcc ttg cca gaa gct tct gca ggc tcc cca gaa aga ggc ccc acc 1392 Ala Ala Leu Pro Glu Ala Ser Ala Gly Ser Pro Glu Arg Gly Pro Thr 450 455 460 ctg gag gag gag ccc cca ggg cct gag ccc agg att ggg gct cta ggt 1440 Leu Glu Glu Glu Pro Pro Gly Pro Glu Pro Arg Ile Gly Ala Leu Gly 465 470 475 475 480 gtc aag gtt ttc cgc tcc agg ata gca tgc ctgc gc cgg gac 1488 Val Lys Val Phe Arg Ser Arg Ile Ala Cys Leu Pro Gly Gly Arg Asp 485 490 495 agg gct ggg cgg ccc ctg ctt ctg gtg tca act aca gag ggg gcc tgg 1536 Arg Ala Gly Arg Pro Leu Leu Leu Val Ser Thr Thr Glu Gly Ala Trp 500 505 510 gag gca cca tgg tgc aca gtt tca gag gtc acc aag cta ctg tcc tac 1584 Glu Ala Pro Trp Cys Thr Val Ser Glu Val Thr Lys Leu Leu Ser Tyr 515 520 525 ctg tgt acc atc ccc agg cct gaa gat aaa gcc aag ggg ctg gcg gtc 1632 Leu Cys Thr Ile Pro Arg Pro Glu Asp Lys Ala Lys Gly Leu Ala Val 530 535 540 ctg att gac gcc agg aga cag ccc cca cag ccc ggt ctg gtc agc gcc 1680 Asp Ala Arg Arg Gln Pro Pro Gln Pro Gly Leu Val Ser Ala 545 550 555 560 ctg cag gcc acc cag gct cag gtc cca gcc tct atc cgg gct att ctc 1728 Leu Gln Ala Thr Gln Ala Gln Val Pro Ala Ser Ile Arg Ala Ile Leu 565 570 575 ttc ctg ggg gag aag gag gcg gct ctc cag ctg cag aca tta cct gac 1776 Phe Leu Gly Glu Lys Glu Ala Ala Leu Gln Leu Gln Thr Leu Pro Asp 580 585 590 gtc cag gtg ag gtg gtg gag gtg gtg gag gtg gcc ctc agc cac cat gtg 1824 Val Gln Val Glu Val Leu Thr Ser Leu Lys Ala Leu Ser His His Val 595 600 605 gac ccc agc cag ctg ccc gca gtc ctg gaa ggc ccc ttc ccc tac tgc 1872 Asp Pro Ser Gln Leu Prola Val Leu Glu Gly Pro Phe Pro Tyr Cys 610 615 620 cac acc gag tgg gtt cat ttc ttc cag aag ctg gac cct ttc ctt gct 1920 His Thr Glu Trp Val His Phe Phe Gln Lys Leu Asp Pro Phe Leu Ala 625 630 630 635 640 gac ctc cac cag gcc tct tcc ctg cta caa gct tcc atc gag gaa ttc 1968 Asp Leu His Gln Ala Ser Ser Leu Leu Gln Ala Ser Ile Glu Glu Plu 645 650 655 gag aag gcc gac ccc cct ggg ggg atg cag tcc cat gga aga cca agg 2016 Glu Lys Ala Asp Pro Pro Gly Gly Met Gln Ser His Gly Arg Pro Arg 660 665 670 ctg agg ccc ttg gtg aag ggc ctg ccc aca gtc aca cag caa gtt agc 2064 Leu Arg Pro Leu Val Lys Gly Leu Pro Thr Val Thr Gln Gln Val Ser 675 680 685 tgg aaa ccc agg ctg ggg cca cag aga tgg agg ggc agg cct atg cgg 2112 Trp Lys Pro Arg Leu Gly Pro Gln Arg Trp Arg Gly Arg Pro Met Arg 690 695 700 gac aga agt aca gca ggg tgaagagggc aacagaggcc ttttctcacc 2160 Asp Arg Ser Thr Ala Gly 705 710 tccgcccacc tcccaggagc catctggctg cagccactgc cttgtacagc cttgtggacg 2220 agcagcttca tgttctggtc accgcttcca acagcctcct ggggaagctg gagctccgtg 2280 tccgcctggg ccgcctggaa gctgccattc accaggtcag cgactggatg gagcaggaag 2340 gaaggcggtg cctgcaatca ctgaccccca aggatggaag tttggagaca gtggagaaag 2400 cccacgcaga atttgagaac ttcttcctcc aggctgcagc ccagtaccgc cgaggcctgg 2460 agctgtccaa gcaggccgct cagctgggag ctacagccag aggggctggg gaggcagaac 2520 gtgcagagtt cccagagctg gcagcctttg cctctaccca gcgggccttc caggctaagc 2580 tgacccactt ttacatggcg gccg agcggc aacgcacgga cctcgagacg ctgctccacc 2640 tgcaccgctt ctgcaagagg atgacctggt tccacatgga ctgtcaggac ctgatggccc 2700 agctcaggct ggacaagacc tcaagggtca gtcctgggga ccagcgccgc ctccaccgct 2760 acctgcagcg actggcatct gagttccctg ctgagaagct cgcagccgtg gggctgcagg 2820 tggcctccct gagccgggca ggcctgggcc aggagctatg ggaggaggcc cggatcaggc 2880 atgaggagat ctggatgctc ctggagaagg cactgaccca cagctcttgc ccagaggctc 2940 cagctgctca ctcagcgcgc ccagaacgaa gaggggtggc agccaagggc cagggtgtga 3000 gtgtagaggt cacttccaag gggaggtggg atcagcctcc actagactcg ctgggcatgg 3060 accatttgcc aaagtcctat tggcctcctg ggccccccag aggggaacag aacagaactt 3120 tccaggcagg ctctccaccc caggaagctg gccaggctgc agaggctgaa gacggcaaag 3180 gctcccacaa gctgcctgac cctgcccgcg agcatttgct tgccaccacc ttcttccggc 3240 agcagccccc caggcagagc caggtccctc gcctcactgg gggcagcttc tcctcagagg 3300 ggacagactc acagacatcc cttgaggact caccccagac aagtcccctt gcctccctct 3360 agctgagagg ccccttcagt cgcaccagcc tccaggagca ctgggccagg gcccagctgg 3420 aggggtagct gggagctctg gtcagtccc a gtgagacgtc accatggagc actggtttta 3480 cattctgcct ctgctgggag gatgagaact gttgacctgc ccctggctcc agaaaactcc 3540 tggaagaccc gatcctcacc catgcagaat agcaagagtg ggcgtcagaa ccagggcaca 3600 ataaatggtg tgattggctc catccctcca ggctctcatt gtggaaagac ctgtcggcac 3660 agacccctcc agaggtctcg ctcgcaggca ggcagacacc cacctgcagc tcaggaacat 3720 acacagctct cccctcgggt acgagggcca gtgttgccct taggcagaat cctcggggag 3780 attcgggagt gcttccttgt cttggattcc aggaaaatgg accctgagat gaggatttaa 3840 ggatcagtgt gtttggtgct gatccaggaa cctctgctgg gggagtagga ggcgaatctg 3900 caaagggaat aaagagtatg ttgtcaagaa aattttcttt tttttaattt ttaaaacttc 3960 attgtatttt atgtttagag atggggcctc actacattgc ccaggctggt ctcaaactcc 4020 tgggctcaag tgatcctctt gccttggcct gccaaagtgc tgggattgcc ttttccgccc 4080 accccccccg accccaccag agacagggtc tcgctctggt gtccaggctg gagtgcagtg 4140 gtgcaatcat agccttaaat tcctgggttc aaccaatcct cccacctcag cctcctaagt 4200 agctgggact acagttatgc accaccatgc tcagcttatt atttatttat tttttgtaga 4260 catggggtct tgctatgttg cccaggcagg ctga tctcaa gctcaggtga tcctctggac 4320 tcagcctccc aaagtgctgg gattataggt atgagccact gtgccccacc ctcatacaaa 4380 tttccatgtt ggcaactgta gctggatctt tctggagatc tctgaaagac agcatggaat 4440 ccttgaacac cccctgaggc gtgaggcatc cagagcattt atctgccaac cctcaggagc 4500 tggcactcgt agacagcacg cacagccagc tccattggtc ttggcaaaga gaattgcctc 4560 ctggagccag aggccggttc ctgtgcttag aaaggaagga catgtcttct gtgctccctg 4620 tctcacaagg cctcttcagc aggcatgggg ccttcattct caagttcaag gaaccctgtg 4680 gaaccttgtc cttgtcctcc agagagaatc ctctccgcct tagaggtccc tcctctctct 4740 cacctcccca ccaagcctcc ctgaactcaa tgtcttctgt ccccttccct gcccaacttc 4800 cacttctcta tgcccagcct ctgtggccca gtaccattgg ggttctgtgg gcagctgggt 4860 cctggtggtt ggggaccgtg ggaaggggcc tatctgtcgg atcttagatg gagcatccag 4920 aagccccacc cttcatactg gccagagtgg cccctgccag cgcctctctg gagtgtcatt 4980 aagctgaaag tgtttgcctt acctctgcag taggatgcat tactgaagtg gcctcttggt 5040 cacctagctc tgaattttcc tggctccaga aagaggctgt ggggcacagg tcccccacaa 5100 tgaggctgtg aaggggagag aggcaggcct gggccaggc a caggaggaca actagggctt 5160 ctcaggagct gtctcagcca agagtcacac acttgatacc taaaatggct tcaggaatct 5220 tccaagactg aagacttccc caggtgtggt ctagggcctg cctgcctcag agccatgagc 5280 agagccggtc aaaaggcttc ctagggaatc ctaccccaga cattaaaata gactcttggt 5340 gctggcaggt ggctggaatc tgcgtttgta gccaagtgct cttcctgtgt gactcagcaa 5400 agtgggggtg catttgggga acacccgggg ctggggcctg agtcctccac ccaaagccag 5460 gtttgattct tgcattcccc tccctgcctt ccatccagac aggcccaagg atgcaagagg 5520 cgttgatcag cccatctcca tccatgcctg ttgcctcaga gagggccgac ggcttttaaa 5580 atgctgttgc catagcaaca gcatccagcc agtgggtacc acaggcaggg agccacagaa 5640 actggggtgc tgggatggaa actgacttgt gagagaccac agctactgct agaaggaagg 5700 ggggcaaagc gggcacaggt aatctaagaa tacttgggcg ggaggagtcc ccaaggttac 5760 cttgtgcatc cctctgtccc cagaaagaac tgtaccccaa caatctctcc cctcactgca 5820 tcccctgggg aagaagggaa tgcagaaatg aaatgtcata atgagtaaca atgtataaaa 5880 atatcgaata ataacagct 5899 <210> 18 <211> 5490 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (380) .. (4225) <400> 18 gtctgacact gtcggggttc cctacctagt gcttcaacca gatcacctca cttttgagtt 60 tccttcctcc cctttaccct cgcccccact cccaaccccc ttttttggtt tttgtgtttc 120 tgcctcttcc tgcctggggg aggggtcgtc tcctggttgc tttgacggtt tttgagttgt 180 ttttccatgt gaatcggggt ttgaagcgac caccccccac aacctgccac ccccccaccc 240 caccgcccac cctcccgacc ccctcgccca agcgggtccc ccccgctggg accccccggc 300 tactcggtga cgagaagagc tggaaaccag agccagctgg agcgtgctga ggaccaaggc 360 tggtgtggtc cccttataa cct gcc tgg acc ctc cat tca gtc cgc cgc gtg 412 Pro Ala Trp Thr Leu His Ser Val Arg Arg Val 1 5 10 gcc ccg cgc ttc tcc atc ctg ccc atg agc cac gag atc atg cca ggg 460 Ala Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile Met Pro Gly 15 20 25 ggc aac gtg aac atc acc tgc gtg gcc gtg ggc tcg ccc atg cca tac 508 Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro Met Pro Tyr 30 35 40 gtg aag tgg atg cag ggg gcc gag gac ctg acc ccc gag gat gac atg 556 Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu Asp Asp Met 45 50 55 ccc gtg ggt cgg aac gtg ctg g aa ctc aca gat gtc aag gac tcg gcc 604 Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys Asp Ser Ala 60 65 70 75 aac tac acc tgc gtg gcc atg tcc agc ctg ggc gtc att gag gcg gtt 652 Asn Tyr Cys Val Ala Met Ser Ser Leu Gly Val Ile Glu Ala Val 80 85 90 gct cag atc acg gtg aaa tct ctc ccc aaa gct ccc ggg act ccc atg 700 Ala Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly Thr Pro Met 95 100 105 gtg act gag aac aca gcc acc agc atc acc atc acg tgg gac tcg ggc 748 Val Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp Asp Ser Gly 110 115 120 aac cca gat cct gtg tcc tat tac gtc atc gaa tat aaa tcc aag agc 796 Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys Ser Lys Ser 125 130 135 caa gac ggg ccg tat cag att aaa gag gac atc acc acc aca cgt tac 844 Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr Thr Arg Tyr 140 145 150 155 agc atc ggc ggc ctg agc ccc aac tcg gag tac gag atc tgg gtg tcg 892 Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile Trp Val Ser 160 165 170 gcc gtc aac tcc atc ggc cag ggg ccc ccc agc gag tcc gtg gtc acc 940 Ala Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser Val Val Thr 175 180 185 cgc aca ggc gag cag gcc ccg gcc agc gcg ccg cgg aac gtg caa gcc 988 Arg Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn Val Gln Ala 190 195 200 cgg atg ctc agc gcg acc acc atg att gtg cag tgg gag gag ccg gtg 1036 Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu Glu Pro Val 205 210 215 gag ccc aac ggc ctg atc cgc ggc tac cgc gtc tac tac acc atg gaa 1084 Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr Thr Met Glu 220 225 230 235 ccg gag cac ccc gtg ggc aac t cac aac gtg gac gac agc 1132 Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val Asp Asp Ser 240 245 250 ctg ctg acc acc gtg ggc agc ctg ctg gag gac gag acc tac acc gtg 1180 Leu Leu Thr Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr Tyr Thr Val 255 260 265 cgg gtg ctc gcc ttc acc tcc gtc ggc gac ggg ccc ctc tcg gac ccc 1228 Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu Ser Asp Pro 270 275 280 280 atc cag gtc aag acg cag cag gga gtg ccg ggc cag ccc atg aac ctg 1276 Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro Met Asn Leu 285 290 295 cgg gcc gag gcc agg tcg gag acc agc atc acg ctg tcc ccc 1324 Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser Trp Ser Pro 300 305 310 315 ccg cgg cag gag agt atc atc aag tac gag ctc ctc ttc cgg gaa ggc 1372 Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe Arg Glu Gly 320 325 330 gac cat ggc cgg gag gtg gga agg acc ttc gac ccg acg act tcc tac 1420 Asp His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr Thr Ser Tyr 335 340 345 gtgt gtg gag gac ctg aag ccc aac acg gag tac gcc ttc cgc ctg gcg 1468 Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe Arg Leu Ala 350 355 360 gcc cgc tcg ccg cag ggc ctg ggc gcc ttc acc ccc gtg Agg cag cag cag Pro Gln Gly Leu Gly Ala Phe Thr Pro Val Val Arg Gln 365 370 375 cgc acg ctg cag tcc atc tcg ccc aag aac ttc aag gtg aaa atg atc 1564 Arg Thr Leu Gln Ser Ile Ser Pro Lys Asn Phe Lys Val Lys Met Ile 380 385 390 395 atg aag aca tca gtt ctg ctc agc tgg gag ttc cct gac aac tac aac 1612 Met Lys Thr Ser Val Leu Leu Ser Trp Glu Phe Pro Asp Asn Tyr Asn 400 405 410 tca ccc aca ccc tac aag atc cag tac aat ggg ctc aca ctg gat gtg 1660 Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly Leu Thr Leu Asp Val 415 420 425 gat ggc cgt acc acc aag aag ctc atc acg cac ctc aag ccc cac acc 1708 Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr His Leu Lys Pro His Thr 430 435 440 ttc tac aac ttt gtg ctg acc aat cgc ggc agc agc ctg ggc ggc ctc 1756 Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser Ser Leu Gly Gly Leug 445 450 cag acg gtc acc gcc tgg act gcc ttc aac ctg ctc aac ggc aag 1804 Gln Gln Thr Val Thr Ala Trp Thr Ala Phe Asn Leu Leu Asn Gly Lys 460 465 470 470 475 ccc agc gtc gcc ccc aag cct gat gct gac ggc tt gtg tat 1852 Pro Ser Val Ala Pro Lys Pro Asp Ala Asp Gly Phe Ile Met Val Tyr 480 485 490 ctt cct gac ggc cag agc ccc gtg cct gtc cag agc tat ttc att gtg 1900 Leu Pro Asp Gly Gln Ser Pro Val Pro V al Gln Ser Tyr Phe Ile Val 495 500 505 atg gtg cca ctg cgc aag tct cgt gga ggc caa ttc ctg acc ccg ctg 1948 Met Val Pro Leu Arg Lys Ser Arg Gly Gly Gln Phe Leu Thr Pro Leu 510 515 520 ggt agc g gac atg gat ctg gaa gag ctc atc cag gac atc tca 1996 Gly Ser Pro Glu Asp Met Asp Leu Glu Glu Leu Ile Gln Asp Ile Ser 525 530 535 cgg cta cag agg cgc agc ctg cgg cac tcg cgt cag ctgcc ggt Leu Gln Arg Arg Ser Leu Arg His Ser Arg Gln Leu Glu Val Pro 540 545 550 555 555 cgg ccc tat att gca gct cgc ttc tct gtg ctg cca ccc acg ttc cat 2092 Arg Pro Tyr Ile Ala Ala Arg Phe Ser Val Leu Pro Pro Thr Phe His 560 565 570 570 ccc ggc gac cag aag cag tat ggc ggc ttc gat aac cgg ggc ctg gag 2140 Pro Gly Asp Gln Lys Gln Tyr Gly Gly Phe Asp Asn Arg Gly Leu Glu 575 580 585 585 ccc ggc ttcgc ttcgc ttcgc tat gtc ctt gcc gtg ctt cag aag agc 2188 Pro Gly His Arg Tyr Val Leu Phe Val Leu Ala Val Leu Gln Lys Ser 590 595 600 gag cct acc ttt gca gcc agt ccc ttc tca gac ccc ttc cag ctg gat 2236 Glu Pro Thr Phe A la Ala Ser Pro Phe Ser Asp Pro Phe Gln Leu Asp 605 610 615 aac ccg gac ccc cag ccc atc gtg gat ggc gag gag ggg ctt atc tgg 2284 Asn Pro Asp Pro Gln Pro Ile Val Asp Gly Glu Glu Gly Leu Ile Trp 620 625 630 635 gtg atc ggg cct gtg ctg gcc gtg gtc ttc ata atc tgc att gtc att 2332 Val Ile Gly Pro Val Leu Ala Val Val Phe Ile Ile Cys Ile Val Ile 640 645 650 gct atc ctg ctc tac aag aac aaa c cgc aag gac tca 2380 Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser Lys Arg Lys Asp Ser 655 660 665 gaa ccc cgc acc aaa tgc ctc ctg aac aat gcc gac ctc gcc cct cac 2428 Glu Pro Arg Thr Lys Cys Leu Asn Ala Asp Leu Ala Pro His 670 675 680 cac ccc aag gac cct gtg gaa atg aga cgc att aac ttc cag act cca 2476 His Pro Lys Asp Pro Val Glu Met Arg Arg Ile Asn Phe Gln Thr Pro 685 690 695 ggc atg ctt ac cac ccg cca att ccc atc gca gac atg gcg gag cac 2524 Gly Met Leu Ser His Pro Pro Ile Pro Ile Ala Asp Met Ala Glu His 700 705 710 715 acg gag cgg ctc aag gcc aac gac agc ctc aag ctc tcc cag gagtat 2572 Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 720 725 730 gag tcc atc gac cct gga cag cag ttc aca tgg gaa cat tcc aac ctg 2620 Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu His Ser Asn Leu 735 740 745 gaa gtg aac aag ccg aag aac cgc tat gcc aac gtc atc gcc tat gac 2668 Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile Ala Tyr Asp 750 755 760 760 cac tcc cgt gtc atc cc gtc atcc att gaa ggc atc atg ggc agt gat 2716 His Ser Arg Val Ile Leu Gln Pro Ile Glu Gly Ile Met Gly Ser Asp 765 770 775 tac atc aat gcc aac tac gtg gac ggc tac cgg cgt cag aac gcg tac 2764 Tyr Asle Asn An Tyr Val Asp Gly Tyr Arg Arg Gln Asn Ala Tyr 780 785 790 795 att gcc acg cag ggg ccg ctg cct gag acc ttt ggg gac ttc tgg cgt 2812 Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe Gly Asp Phe Trp Arg 800 805 810 atg gtg tgg gag cag cgg tcg gcg acc atc gtc atg atg acg cgg ctg 2860 Met Val Trp Glu Gln Arg Ser Ala Thr Ile Val Met Met Thr Arg Leu 815 820 825 gag gag aag tca cgg atc aag tgt gat cag tat tgg ccc aac aga ggc 2908 Glu Glu Lys Ser Arg Ile Lys Cys Asp Gln Tyr Trp Pro Asn Arg Gly 830 835 840 acg gag acc tac ggc ttc atc cag gtc acg ttg cta gat acc atc gag 2956 Thr Glu Thr Tyr Gly Phe Ile Val Thr Leu Leu Asp Thr Ile Glu 845 850 855 ctg gcc aca ttc tgc gtc agg aca ttc tct ctg cac aag aat ggc tcc 3004 Leu Ala Thr Phe Cys Val Arg Thr Phe Ser Leu His Lys Asn Gly Ser 860 865 870 875 agt aaa cgc gag gtc cgc cag ttc cag ttt acg gcg tgg ccg gac 3052 Ser Glu Lys Arg Glu Val Arg Gln Phe Gln Phe Thr Ala Trp Pro Asp 880 885 890 cat ggc gtg ccc gaa tac cca acg ccc ttc ctg gct 3100 His Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu Ala Phe Leu Arg Arg 895 900 905 gtc aag acc tgc aac ccg cca gat gcc ggc ccc atc gtg gtt cac tgc 3148 Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro Ile Val Val His Cys 910 915 920 agt gcc ggt gtg ggc cgc aca ggc tgc ttt atc gtc atc gac gcc atg 3196 Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val Ile Asp Ala Met 925 930 935 935 ctt gag cgg atc aag cca gag aag aca gtc gat gtc tat ggc cac gtg 3244 Leu Glu Arg Ile Lys Pro Glu Lys Thr Val Asp Val Tyr Gly His Val 940 945 950 955 acg ctc atg agg tcc cag cgc aac tac atg gtg cag acg gag gac cag 292 Thrag Met Arg Ser Gln Arg Asn Tyr Met Val Gln Thr Glu Asp Gln 960 965 970 tac agc ttc atc cac gag gcc ctg ctg gag gcc gtg ggc tgt ggc aac 3340 Tyr Ser Phe Ile His Glu Ala Leu Leu Glu Aly Val Gly Cy 975 980 985 aca gaa gtg ccc gca cgc agc ctc tat gcc tac atc cag aag ctg gcc 3388 Thr Glu Val Pro Ala Arg Ser Leu Tyr Ala Tyr Ile Gln Lys Leu Ala 990 995 1000 cag gtg gag cct ggc gag cac gtc gag cac gtc gag cac gtc gag cac gtc gaa ctc gag ttc aag 3436 Gln Val Glu Pro Gly Glu His Val Thr Gly Met Glu Leu Glu Phe Lys 1005 1010 1015 cgg ctg gct aac tcc aag gcc cac acg tca cgc ttc atc agt gcc aat 3484 Arg Leu Ala Asn Ser Lys Thr Ser Arg Phe Ile Ser Ala Asn 1020 1025 1030 1035 ctg cct tgt aac aag ttc aag aac cgc ctg gtg aac atc atg ccc tat 3532 Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile Met Pro Tyr 1040 1045 1050 gag agc aca cgg gtc tgt ctg caa ccc atc cgg ggt gtg gag ggc tct 3580 Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg Gly Val Glu Gly Ser 1055 1060 1065 gac tac atc aac gcc agc ttc tt gatgg cag cag aag gcc 3628 Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Gln Lys Ala 1070 1075 1080 tac atc gcg aca cag ggg ccg ctg gcg gag acc acg gaa gac ttc tgg 3676 Tyr Ile Ala Thr Gla Gly Pro Glu Thr Thr Glu Asp Phe Trp 1085 1090 1095 cgc atg ctg tgg gag aac aat tcg acg atc gtg gtg atg ctg acc aag 3724 Arg Met Leu Trp Glu Asn Asn Ser Thr Ile Val Val Met Leu Thr Lys 1100 1105 1110 1115 ctg cgg atg ggc cgg gag aag tgt cac cag tac tgg ccg gcc gag 3772 Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp Pro Ala Glu 1120 1125 1130 cgc tct gcc cgc tac cag tac ttt gtg gta gat ccg atgca 820 Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met Ala Glu Tyr 1135 1140 1145 aac atg cct cag tat atc ctg cga gag ttc aag gtc aca gat gcc cgg 3868 Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys Val Thr Asp Ala Arg 1150 1155 1160 gat ggc cag tcc cgg act gtc cgg cag ttc cag ttc aca gac tgg ccg 3916 Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln Phe Thr Asp Trp Pro 1165 1170 1175 gaa ca ggt gtg cca aag tcg ggg gag ggc ttc atc gac ttc att ggc 3964 Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile Gly 1180 1185 1190 1195 caa gtg cat aag act aag gag cag ttt ggc cag gac tct 4012 Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile Ser 1200 1205 1210 gtc cac tgc agt gcc ggc gtg ggc agg acg ggc gtc ttc atc acg ctt 4060 Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr Leu 1215 1220 1225 agc atc gtg ctg gag cgg atg cgg tat gaa ggc gtg gtg gac atc ttt 4108 Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile Phe 1230 1235 1240 cag acg cg gag atg acc cag cgg ccg gcc atg gtg cag aca 4156 Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro Ala Met Val Gln Thr 1245 1250 1255 gag gat gag tac cag ttc tgt tac cag gcg gca ctg gag tac ctc gga 4204 Glu Asp Glu Tyr Gln Phe Cys Tyr Gln Ala Ala Leu Glu Tyr Leu Gly 1260 1265 1270 1275 agc ttt gac cac tat gca acc taaagccatg gtccccccca ggcccgacac ggcccgccc cc gcc ccg ccccc cc gcc cc gcc cc gcc cc gcc cc gcc ggaggtggca gcggcagcag ctgtgtttct gcaccatttc cgaggacgac 4375 gcagcccctc gagccccccc accggccccg gccgccccag cgacctccct ggcaccggcc 4435 gccgccttca aatacttggc acattcctcc tttccttcca attccaaaac cagattccgg 4495 ggtggggggt ggggggatgg tgagcaaata ggagtgctcc ccagaaccag aggagggtgg 4555 ggcacagacc atagacggac ccctcgtcct cccccagcgg tggtaggggg acccgggggg 4615 ctcctccccg ctctgcagcc tggggacact gggctgggac cagaatccag ctttctttta 4675 aaactctcag tgtaactgta tcccgtgaca tttcattttt tttaaatagt gtattttttt 4735 tccatttttt tttttttaag agaaacaaaa gactcgccag tcaatgactt tcaaagagaa 4795 ctaactttgg cttattcata ttctgttcaa agacagtcta ttttttcact gtagaaagcg 4855 tccttgtgtg atagttacgt tcgcaaacgc gcacgccagg cccatttctttttttttttttttttttttt tttaattttt cctaccatca gaaagtgtgc tttgctcaca 4975 gaagaatggg atgtcctttt ttctttcttg gctttttttt tccccctttt tgtttcattt 5035 ttataaatta aattttcaga catatcaaat acagttctga gggtaaggtc atgggggagc 5095 tcggacccag tggcgttggg tgcggttgag ggggacgctg ctgtaagagg agagagatga 5155 cagtggtcct cctctgagag cctgagctgt ctccccgtct cccgccccca aggagacaga 5215 gaggatccta cttcttcggg gacagtggct gtatggctgt gctgccccac atcagggacc 5275 ctttccccct gggactatgg ggcagtttgg gagcaaaacc agaaggacag gcccccctct 5335 acccgcctac cctgagcaag cgagttgttc ctctttgtac aagggcaggt ctgcggttac 5395 tttcaacact gtttattcca gcggaagcag ccgggtggtt ttcccacccc cgtgtatgta 5455 gatatatcga ctttgtatta aaggaagatc gtctg 5490 <210> 19 <211> 5933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1025) <400> 19 gg agc gca ggc tca gct ccg cgc tgc gag cgc tac ggg cgc agg ggc 47 Ser Ala Gly Ser Ala Pro Arg Cys Glu Arg Tyr Gly Arg Arg Gly 1 5 10 15 ggg gag ccg gcc cgg agc gca gtt tcc ggg gcc ggg gtt tca ccc 95 Gly Glu Pro Ala Arg Ser Ala Val Ser Ser Gly Ala Gly Val Ser Pro 20 25 30 ggg ccc tct ctg ttt gaa ccg aac ccg aca aat ggg cgc atg acg atg 143 Gly Pro Ser Leu Phe Glu Pro Asn Pro Thr Asn Gly Arg Met Thr Met 35 40 45 gag agc agg gaa atg gac tgc tat ctc cgt cgc ctc aaa cag gag ctg 191 Glu Ser Arg Glu Met Asp Cys Tyr Leu Arg Arg Leu Lys Gln Glu Leu 50 55 60 atg tcc atg aag gag gtg ggt gat ggc tta cag gat cag atg aac tgc 239 Met Ser Met Lys Glu Val Gly Asp Gly Leu Gln Asp Gln Met Asn Cys 65 70 75 atg atg ggt gca ctg caa gaa ctg aag ctc ccc cagcag 287 Met Met Gly Ala Leu Gln Glu Leu Lys Leu Leu Gln Val Gln Thr Ala 80 85 90 95 ctg gaa cag ctg gag atc tct gga ggg ggt cct gtg cca ggc agc cct 335 Leu Glu Gln Leu Glu Ile Ser Gly Gly Gly Pro Val Pro Gly Ser Pro 100 105 110 gaa ggt ccc agg acc cag tgc gag cac cct tgt tgg gag ggt ggc aga 383 Glu Gly Pro Arg Thr Gln Cys Glu His Pro Cys Trp Glu Gly Gly Arg 115 120 125 ggt cct gcc agg ccc aca gtc tgt tcc ccc tcc agt caa cct tct ctt 431 Gly Pro Ala Arg Pro Thr Val Cys Ser Pro Ser Ser Gln Pro Ser Leu 130 135 140 ggc agc agc acc aag ttt cca tcc cat agg agt gtc tgt gga agg gat 479 Gly Ser Ser Thr Lys Phe Pro Ser His Arg Ser Val Cys Gly Arg Asp 145 150 155 tta gcc ccc ttg ccc agg aca cag cca cat caa agc tgt gct cag cag 527 Leu Ala Pro Leu Pro Arg Thr Gln Pro His Gln Ser Cys Ala Gln Gln 160 165 170 175 ggg cca gag cga gtg gaa ccg gat gac tgg acc tcc acg ttg atg tcc 575 Gly Pro Glu Arg Val Glu Pro Asp Asp Trp Thr Ser Thr Leu Met Ser 180 185 190 cgg ggc cgg aat cga cag cct ctg gtg tta ggg gac aac gtt ttt gca 623 Arg Gly Arg Asn Arg Gln Pro Leu Val Leu Gly Asp Asn Val Phe Ala 195 200 205 gac ctg gtg ggc aat tgg cta gac ttg cca gaa ctg gag aag ggt ggg 671 Asp Leu Val Gly Asn Trp Leu Asp Leu Pro Glu Leu Glu Lys Gly Gly215 220 gag aag ggt gag act ggg ggg gca cgt gaa ccc aaa gga gag aaa ggc 719 Glu Lys Gly Glu Thr Gly Gly Ala Arg Glu Pro Lys Gly Glu Glu Lys Gly 225 230 235 cag ccc cag gag ctg ggc cgc agg ttca gcc gca aac atc ttt 767 Gln Pro Gln Glu Leu Gly Arg Arg Phe Ala Leu Thr Ala Asn Ile Phe 240 245 250 255 aag aag ttc ttg cgt agt gtg cgg cct gac cgt gac cgg ctg ctg aag 815 Lys Lys Phe Leu Arg Ser Val Pro Asp Arg Asp Arg Leu Leu Lys 260 265 270 270 gag aag cca ggc tgg gtg aca ccc atg gtc cct gag tcc cga acc ggc 863 Glu Lys Pro Gly Trp Val Thr Pro Met Val Pro Glu Ser Arg Thr Gly 275 280 285 cgc tca cag aag gtc aag aag cgg agc ctt tcc aag ggc tct gga cat 911 Arg Ser Gln Lys Val Lys Lys Arg Ser Leu Ser Lys Gly Ser Gly His 290 295 300 ttc ccc ttc cca ggc acc ggg gag cac agg cga ggg gag aat ccc ccc 959 Phe Pro Phe Pro Gly Thr Gly Glu His Arg Arg Gly Glu Asn Pro Pro 305 310 315 aca agc tgc ccc aag gcc ctg gag cac tca ccc tca gga ttt gat att 1007 Thr Ser Cys Pro Lys Ala Leu Glu His Ser Pro Ser Gly Ph e Asp Ile 320 325 330 335 aac aca gct gtt tgg gtc tgaatcctag agacagaaag ttgactgagc 1055 Asn Thr Ala Val Trp Val 340 ctgaaagggc caggtcccag tgctgggccc ctggggagga gggagggtgg gcggtatggc 1115 tctcgaaagc ccaactccaa gttcctttcc cccagaaagc ggggagaagc cagagttctt 1175 ggctcaggac tgaagggaag gtggttggga gaggctgtct tgggggctag ctggtggagg 1235 aggtaagagt agctggagag tgagctgtgc gtgtgtgtgt gtgtgtgtgc atgtgtgtgt 1295 ctgtctggca tgcatgcact cactttgggg ctggaggtga cagtaggtga gggcagagga 1355 ggagatcaga aaatccctct gacatctcca ctgcccccaa agacctccgt tgaacattct 1415 gtatggaaaa gagccctgga gcatcaggtt ccccagatag gcccccaaat aaagacctgt 1475 ctatggctct cccaaccttc tgtcagcttc tttggcaaga cattgctcca ggcacaggga 1535 ctgaacccca ggcctcctgg gactggagca gcagtgaggc aaaacccgac ctgctagccc 1595 tttctgcctt ggaggtttca gtccatacct ggactctgag aaaatgagct gaataaggag 1655 tacagtgtgt aaggagcagc cagggaagcc ctagacactc cccgcgtctc ccccatgcac 1715 aggggaagga tgttgacata gcactgggct gtttgaatgc cttttcatct ccatggtctc 1775 atttgaaagt gagcgaggca ggcaggcat g atcccatttt ccagataagg aaacaagcct 1835 agatatgcta catgtccagg aacaactgca gccaggaggc agaacagcct aggtctaact 1895 gcagagtaga agctggaccc tggagttacc aacactcctc cccaacagtt cttagcaccc 1955 cgcaggctgg gcgctgtggc tcacgcctgt aatcccagca ctttgggagg gcaaggcagg 2015 cggattacct ggggtcagga gttcatgacc agcctggcca acatggtgaa accccgtctc 2075 tactaaaaaa atacgtaaaa attagccagg cgtggtggca cacgcctgta aacccagcta 2135 cttgggaggc tgaggcagga gaattgcttg agcccgggag agggaggttg cagtgaggcg 2195 agatcatgcc actgcactcc agcctggctg acagagcaag actcccctgt ctcaaaaaaa 2255 aataaaaaaa aacagttcgt agggccccat accccacaac ccctgtctcc tgcacttaac 2315 tcccacctgg gtcagagaac agccaattca ccagtgaggt agaagtgaac ccagaagaaa 2375 tagccacttg attttaaaat tcccagctcc attccgtggc cttctcccca ctagacacag 2435 cagtcccagg cctcctgttc cctcctcacc tagaggcagc cgggacggag ggggaagggc 2495 caggcagcag ctcagctccg gcttctctaa agccactctg ggcacgtggc ccaggagggc 2555 cacctagtga tccaggcccc cccccaggac tgccctggga agccactgtc cctcccactc 2615 cagtagggaa cactcactgg ctgggaaaag acaa tgtgga tcttcttttg ggctgaccaa 2675 gccaggaggg cacaccctcc cactgcccct ctctgcctcc cactgattgt ccctcagcct 2735 gatggggtgt gacagctgca attagaggca ggattccttc ccaccctcaa agcattaata 2795 gccagttgga gaggcaaaat agtaagaaaa ggctcttctg cttgcttcct ggatccctgg 2855 ggagagtgga gagaggggca gagctcaaga tgggattatg ggggcgcagc cgcggtggtt 2915 agggtcactc tcaaatccta cccagtcaaa tggtaagatg tttcattttt ggtgggggag 2975 ctgcaggagg gaggaaggcg ctcatgcttt ttgggttttg ttgagcactc actgtctgtc 3035 aggtaatgtg cacatctctc aaacttagaa ggaccctaga aggcattgtt ctccagacac 3095 atctatggag gttattaggg ggcgtgtaaa ctgccccgat taggctgcta gcaaaggaaa 3155 ggacagagat ttgaacagag ggttgggtta tctggctcca aaacccctgt ccttttcttg 3215 ctatttctct acctggagtt tgccaactga gcaagcccac tctggtggag ccagccactg 3275 caaatccttt gtgtcttccc agagaatacc aacatttcag ttttgagtga gggaacgttg 3335 gctctgactg cctttggagg tggagatggt ggaggtggtg gtggtggtgg tggtagtggt 3395 ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgcctg cgcgtgctaa gaaactgcat 3455 gttaagattc cacctactga atcatgagcg gaggaagtc g tgggacactg gctggtggag 3515 aagccatcta gcatattatt caagatgaca ccagctccaa gtctggaatg agtctgtggg 3575 aaaccaaggt acttcttgga cattcaccta taactcacgt gtttcgtgga ctggtcacag 3635 tggttcggat aaattgaaca gaactttatg aacacctccc agcaccaggt gttgttatag 3695 aaactaagaa cagagcaatg agaaggaccc aactcctgct ctcaaatgga tgcagtggaa 3755 aataagcaga ctttgaacca ttggttagtc agaagagact tgggagactg aaaacttgtt 3815 tcaacttggg ccagaacaaa aaattaggaa gcaacacttg ctgccaacat gatttacaag 3875 tgccagcacc ttcacctctg ttacttcctt ctcactacac actgaaagca gttgctcttg 3935 ttttacatgg acaggctcag agaagttaag caacttgtcc aaggtcacac agtagtggaa 3995 ttgagattga atcagttcca actgacttgc aatcttgtgc ttttcagacg atcccactaa 4055 ttgtccatat ctgttccaaa gccaaatcaa gaggaacaag agcaaaatct gtcctctcat 4115 attattcatg gtcctgcgtg gatcataaat ggcatgctga ctgtctgatg gagacttact 4175 tttcccttcc ccctggacac ctgccatggc aatgacagag gctgtatttt actgaagtgg 4235 agggaagagg tgaatgcaaa tgcctagggc ctaagtatac aggaaggtgt agggagaggt 4295 aagcagtgtg tatgtggagg agatagcaga cgtaagcaga gaga aatcag agagcttagt 4355 tcttcctctg gggcgcactt tgtggttaat taggacatgc aaatgagcta gaagctcatt 4415 taatatcctc cctgacatgt agccccaccc caccctgccc cacttccctg gcaggtacaa 4475 gggccacctg attggcccag gtatctgtgg aaggttccac ctgcttcttt gtggcccagg 4535 gaacagaaaa gagtccctgc tgggcatgct agtggggccg gcctggtctc cctcctccct 4595 ttctcttccc aacctttcag acttgggacc tctcttttcc ctctccctca gacacttccc 4655 ttgtgccccg cccctcaggg tgatctctga acccaaactt gccccaaaga aggttgctct 4715 gtcctctcca catccccatc tcctccctag ggccttgttg gggagaggct cctccatctt 4775 tcccaagtca caccatcgtt tcctacgtgg tctggacaag agcaagagca caccttgtcc 4835 ccaccttctc cagagcagcc agaacccacc tcaggtgcct tccccatccg gtgcagttaa 4895 ggcacttctg ccagcaccat ggtatgagca ctagacttgg agttaagatt tgagagcccc 4955 ctctgtcact gtggaagctt gagcatgttg cttgatctct ctgaaccttg tgtttctcat 5015 ctgtgaaagg tgataatgtg gggctgctgt gagatttaaa ggacataatg cacctacggt 5075 ccaagcactg cctggaatac agcagaagct cagcagatac tggacaaccc atccccttag 5135 tagaggcact aaccatgtga cccaaggcaa aagggcttaa gaaaaagtg c tttctctgag 5195 cgttggtctc ttcttctgtc gaaacattta tattgattta atatctcaca ggattgtagc 5255 aagggtcaga gaagacaata ggtgacatgt ttttgtacac tgtatactag ccacccagat 5315 gggctgttat ttgctaaatg gcaaatttac actgttcccc aaaggatgac atgcactggg 5375 gaggcggggg gtgtggaggt ggagaaaggc tgagcttgga gaaaaggtgc ttgaggaccc 5435 cactgcctaa ggacctgctc taggaaacat tcccactccc tacaccctag ctgcccctca 5495 cagtcaaccc ttaaggacct caaattcttg gcaaggggta aagagttgaa agtgccaagt 5555 cctagtggtt ttgagaagcc tctggtctgc tctttctgct ctgtaaagtc ttagttgcca 5615 gagtccccta tagcccccac atcgctccct tcctcctgcc ctccggccac cctggaaact 5675 aatggcctaa aggtgctgtg gctgtcctcc taaaatccat tccctcctga tggggtggag 5735 gaatctgtga agcccacctt caggagaggt ctcggggctc gggctggtgc tgccagagaa 5795 agggtgactg aaccagaaag gcctagggga aagcagctca aactgcagcc atccccttag 5855 tacgattact aggatgtccc ttgccttcct tttgcctcct ccacccaacc cctaaaataa 5915 acagtatgat gaaacctc 5933 <210> 20 <211> 6697 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3811) <400> 20 c atg gac ctg ctg acc agg gag aat gtg gcc ctc aag gtg gag tca gcc 49 Met Asp Leu Leu Thr Arg Glu Asn Val Ala Leu Lys Val Glu Ser Ala 1 5 10 15 cag cag ccc aag cag gtc ctc aag atg gag gtg gcc gtg ctc aag aag 97 Gln Gln Pro Lys Gln Val Leu Lys Met Glu Val Ala Val Leu Lys Lys 20 25 30 ttg caa ggg aag gac cat gtg tgc agg ttc att ggc tgt ggc agg aac 145 Leu Gp Gly His Val Cys Arg Phe Ile Gly Cys Gly Arg Asn 35 40 45 gag aag ttt aac tat gta gtg atg cag ctc cag ggc cgg aac ctg gcc 193 Glu Lys Phe Asn Tyr Val Val Met Gln Leu Gln Gly Arg Asn Leu Ala 50 55 60 gac ctg cgc cgt agc cag ccg cga ggc acc ttc acg ctg agc acc aca 241 Asp Leu Arg Arg Ser Gln Pro Arg Gly Thr Phe Thr Leu Ser Thr Thr 65 70 75 80 ttg cgg ctg ggc aag cag atc ttg gag tcc gag gag atc cac tct 289 Leu Arg Leu Gly Lys Gln Ile Leu Glu Ser Ile Glu Ala Ile His Ser 85 90 95 gtg ggc ttc ctg cac cgt gac atc aag cct tca aac ttt gcc atg ggc 337 Val Gly Phe Leu His Arg Asp Ile Lys Pro Ser Asn Phe Ala Met Gly 100 105 1 10 agg ctg ccc tcc acc tac agg aag tgc tat atg ctg gac ttc ggg ctg 385 Arg Leu Pro Ser Thr Tyr Arg Lys Cys Tyr Met Leu Asp Phe Gly Leu 115 120 125 gcc cgg cag tac acc aac acc acg ggg gat gtg cgg ccc cct cgg aat 433 Ala Arg Gln Tyr Thr Asn Thr Thr Gly Asp Val Arg Pro Pro Arg Asn 130 135 140 gtg gcc ggg ttt cga gga acg gtt cgc tat gcc tca gtc aat gcc cac 481 Val Ala Gly Phe Arg Gly Thr Val Arg Tyr Ala Ser Val Asn Ala His 145 150 155 160 aag aac cgg gag atg ggc cgc cac gac gac ctg tgg tcc ctc ttc tac 529 Lys Asn Arg Glu Met Gly Arg His Asp Asp Leu Trp Ser Leu Phe Tyr 165 170 175 atg ctg gtg ttt gca gtg ggc cag ctg ccc tgg agg aag atc aag 577 Met Leu Val Glu Phe Ala Val Gly Gln Leu Pro Trp Arg Lys Ile Lys 180 185 190 gac aag gaa cag gta ggg atg atc aag gag aag tat gag cac cgg atg 625 Lys Glu Gln Val Gly Met Ile Lys Glu Lys Tyr Glu His Arg Met 195 200 205 ctg ctg aag cac atg ccg tca gag ttc cac ctc ttc ctg gac cac att 673 Leu Leu Lys His Met Pro Ser Glu Phe His Leu Phe Leu AspIle 210 215 220 gcc agc ctc gac tac ttc acc aag ccc gac tac cag ttg atc atg tca 721 Ala Ser Leu Asp Tyr Phe Thr Lys Pro Asp Tyr Gln Leu Ile Met Ser 225 230 235 240 gtg ttt gag aac agc atg aag gag agg ggc att gcc gag aat gag gcc 769 Val Phe Glu Asn Ser Met Lys Glu Arg Gly Ile Ala Glu Asn Glu Ala 245 250 255 ttt gac tgg gag aag gca ggc acc gat gcc ctc ctg tcc acg agc acc 817 Phe Asp Trp Glu Lys Gly Thr Asp Ala Leu Leu Ser Thr Ser Thr 260 265 270 tct acc ccg ccc cag cag aac acc cgg cag acg gca gcc atg ttt ggg 865 Ser Thr Pro Pro Gln Gln Asn Thr Arg Gln Thr Ala Ala Met Phe Gly 275 280 285 gtg gtc aat gtg acg cca gtg cct ggg gac ctg ctc cgg gag aac acc 913 Val Val Asn Val Thr Pro Val Pro Gly Asp Leu Leu Arg Glu Asn Thr 290 295 300 gag gat gtg cta cag gga gag cac ctg agt gac cag gag aat gca ccc 961 Glu Asp Val Leu Gln Gly Glu His Leu Ser Asp Gln Glu Asn Ala Pro 305 310 315 320 cca att ctg ccc ggg agg ccc tct gag ggg ctg ggc ccc agt ccc cac 1009 Pro Ile Leu Pro Gly Arg Pro Ser Glu Gly Leu Gly Pro Ser Pro His 325 330 335 ctt gtc ccc cac ccc ggg ggt cct gag gct gaa gtc tgg gag gag aca 1057 Leu Val Pro His Pro Gly Gly Pro Glu Ala Glu Val Trp Glu Glu Thr 340 345 350 350 gat gtc aac cgg aac aaa ctc cgg atc aac atc ggc aaa agc ccc tgt 1105 Asp Val Asn Arg Asn Lys Leu Arg Ile Asn Ile Gly Lys Ser Pro Cys 355 360 365 gtg gag gag gaa cag agc cga ggc atg ggg gtc ccc agc tcc cca glug Glu Gln Ser Arg Gly Met Gly Val Pro Ser Ser Pro Val 370 375 380 cgt gcc ccc cca gac tcc ccc aca acc cca gtc cgt tct ctg cgc tac 1201 Arg Ala Pro Pro Asp Ser Pro Thr Thr Pro Val Arg Ser Leu Arg Tyr 385 390 395 400 cgg agg gtg aac agc cct gag tca gaa agg ctg tcc acg gcg gac ggg 1249 Arg Arg Val Asn Ser Pro Glu Ser Glu Arg Leu Ser Thr Ala Asp Gly 405 410 415 cga gtg gag cta cct gag agg agg tca cg gat ctg cct ggc tcg 1297 Arg Val Glu Leu Pro Glu Arg Arg Ser Arg Met Asp Leu Pro Gly Ser 420 425 430 ccc tcg cgc cag gcc tgc tcc tct cag cca gcc cag atg ctg tca gtg 1345 Pro Ser Arg Gln Ala Cys Ser Ser Gln Pro Ala Gln Met Leu Ser Val 435 440 445 gac aca ggc cac gct gac cga cag gcc agt ggc cgc atg gac gtg tca 1393 Asp Thr Gly His Ala Asp Arg Gln Ala Ser Gly Arg Met Asp Val Ser 450 455 460 gcc tct gtg gag cag gag gcc ctg agc aac gcc ttc cgc tcg gtg ccg 1441 Ala Ser Val Glu Gln Glu Ala Leu Ser Asn Ala Phe Arg Ser Val Pro 465 470 475 480 480 ctg gct gag gag gag gat ttc gac agc gtc gag agc gtc gac agc gtc atg agc atc gac 1489 Leu Ala Glu Glu Glu Asp Phe Asp Ser Lys Glu Trp Val Ile Ile Asp 485 490 495 aag gag acg gag ctc aag gac ttc cct cca ggg gct gag ccc agc aca 1537 Lys Glu Thr Glu Leu Lys Asp Phe Pro G Ala Glu Pro Ser Thr 500 505 510 tcg ggc acc acg gat gag gag ccc gag gag ctg cgg cca ctg ccc gag 1585 Ser Gly Thr Thr Asp Glu Glu Pro Glu Glu Leu Arg Pro Leu Pro Glu 515 520 525 gag ggc gaa gag cgg cgg cgg ctg ggg gca gag ccc acc gtc cgg ccc 1633 Glu Gly Glu Glu Arg Arg Arg Leu Gly Ala Glu Pro Thr Val Arg Pro 530 535 540 cgg gga cgc agc atg cag gcg ctg gcg gag gag gac ctg cag cat ttg 1681 ly Arg Ser Met Gln Ala Leu Ala Glu Glu Asp Leu Gln His Leu 545 550 555 560 ccg ccc cag ccc ctg cca ccc cag ctg agc cag ggc gat ggc cgt tcc 1729 Pro Pro Gln Pro Leu Pro Pro Gln Leu Ser Gln Gly Asp G Arg Ser 565 570 575 gag acg tca cag ccc ccc acg cct ggc agc cct tcc cac tca ccc ctg 1777 Glu Thr Ser Gln Pro Pro Thr Pro Gly Ser Pro Ser His Ser Pro Leu 580 585 590 590 cac tcg gga ccc cgc cct cga cgg aga gag tcg gac ccc aca ggc cca 1825 His Ser Gly Pro Arg Pro Arg Arg Arg Glu Ser Asp Pro Thr Gly Pro 595 600 605 cag aga cag gtg ttc tcc gtg gcg ccc cca ttt gag gtg aat ggc ctc 1873 Gln Arg Gln Val Phe Val Ala Pro Pro Phe Glu Val Asn Gly Leu 610 615 620 cca cga gct gtg cct ctg agt ctg ccc tac cag gac ttc aaa aga gac 1921 Pro Arg Ala Val Pro Leu Ser Leu Pro Tyr Gln Asp Phe Lys Arg Asp 625 630 635 640 ctc tcc gat tac cga gaa cgg gcg cgg ttg ctc aac agg gtc cgg agg 1969 Leu Ser Asp Tyr Arg Glu Arg Ala Arg Leu Leu Asn Arg Val Arg Arg 645 650 655 655 gtg ggc ttc tcg cac atg acccg cc atg accg c cca ctg gct 2017 Val Gly Phe Ser His Met Leu Leu Thr Pro Gln Val Pro Leu Ala 660 665 670 cct gtt cag cct cag gct aat ggg aag gag gaa gag gag gag gag gag 2065 Pro Val Gln Pro Gln Ala Asn Gly Lys Glu Glu Glu Glu Glu Glu Glu 675 680 685 gaa gat gag gaa gag gaa gaa gag gat gag gaa gaa gaa gag gag gaa 2113 Glu Asp Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu gag 690 gag gaa gaa gag gag gag gag gaa gag gag gag gag 2161 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 705 710 715 720 gct gca gcg gca gtt gcc ttg ggg gag gtg ctg ggg cgg Ala Ala Ala Ala Val Ala Leu Gly Glu Val Leu Gly Pro Arg Ser Gly 725 730 735 tcc agc agt gag ggg agt gag agg agc act gac cgg agc cag gag ggt 2257 Ser Ser Ser Glu Gly Ser Glu Arg Ser Thr Asp Arg Ser Gln Glu Gly 740 745 750 gcc ccg tcc acg ctg ctg gca gac gat cag aag gag tcc agg ggc cgg 2305 Ala Pro Ser Thr Leu Leu Ala Asp Asp Gln Lys Glu Ser Arg Gly Arg 755 760 765 gcc tcc atg gcc gatggg gac gag cct gag gag ggc tcc aaa acg 2353 Ala Ser Met Ala Asp Gly Asp Leu Glu Pro Glu Glu Gly Ser Lys Thr 770 775 780 ctg gtg ctt gtc tct cct ggc gac atg aag aag tcg ccc gtc act gcc 2401 Leu Val Leu Pro Gly Asp Met Lys Lys Ser Pro Val Thr Ala 785 790 795 800 gaa ctg gcc ccc gac ccc gac ctg ggc acc ctg gct gcc ctc act cct 2449 Glu Leu Ala Pro Asp Pro Asp Leu Gly Thr Leu Ala Ala Leu Thr Pro 805 810 815 cag cat gag cgg ccc cag ccc acg ggc agc cag ctg gac gta tct gag 2497 Gln His Glu Arg Pro Gln Pro Thr Gly Ser Gln Leu Asp Val Ser Glu 820 825 830 cca ggc acc ctg tcc tct gtc ctc aag tct gag ccc ag ccc ccg ggg 2545 Pro Gly Thr Leu Ser Ser Val Leu Lys Ser Glu Pro Lys Pro Pro Gly 835 840 845 cct ggg gca ggg ctg ggg gcc ggg aca gtg acc aca ggg gtc ggg ggc 2593 Pro Gly Ala Gly Leu Gly Ala Gly Thr Val Thr Thr Gly Val Gly Gly 850 855 860 gtg gca gtc acc tcc tca ccc ttc acc aaa gtt gag agg acc ttt gtg 2641 Val Ala Val Thr Ser Ser Pro Phe Thr Lys Val Glu Arg Thr Phe Val 865 870 875 880 cac att gcg gag aaa acc cac ctc aac gtc atg tct tcc ggt gga caa 2689 His Ile Ala Glu Lys Thr His Leu Asn Val Met Ser Ser Gly Gly Gln 885 890 895 gcc ttg cgg tct gag gag ttc agc gct ggg ggc gag gct ggt 2737 Ala Leu Arg Ser Glu Glu Phe Ser Ala Gly Gly Glu Leu Gly Leu Glu 900 905 910 ctg gcc tct gat ggg ggc gct gtg gag gag ggg gcc cga gcg ccc ctg 2785 Leu Ala Ser Asp Gly Gly Ala Val Glu Glu Gly A Ala Pro Leu 915 920 925 gag aac ggc ctc gcc ctg tca ggg ctg aat ggg gct gag ata gag ggc 2833 Glu Asn Gly Leu Ala Leu Ser Gly Leu Asn Gly Ala Glu Ile Glu Gly 930 935 940 tct gcc ccg cgg ggg gaa acc ccc tca gag atg gcc aca 2881 Ser Ala Leu Ser Gly Ala Pro Arg Glu Thr Pro Ser Glu Met Ala Thr 945 950 955 960 aac tca ctg ccc aat ggc ccg gcc ctt gca gac ggg cca gcc ccg gtg 2929 Asn Ser Leu Pro Asn Gly Pro Ala Leu Ala Asp Gly Pro Ala Pro Val 965 970 975 tcc ccg ctg gag cca agc cct gag aaa gtg gcc acc atc tcc ccc aga 2977 Ser Pro Leu Glu Pro Ser Pro Glu Lys Val Ala Thr Ile Ser Pro Arg 9 80 985 990 cgc cat gct atg cca ggc tct cgc ccc agg agc cgt atc cct gtc ctg 3025 Arg His Ala Met Pro Gly Ser Arg Pro Arg Ser Arg Ile Pro Val Leu 995 1000 1005 ctc tct gag gag gac acg ggc tcgcagcc ggc tca ctg tcg gcc 3073 Leu Ser Glu Glu Asp Thr Gly Ser Glu Pro Ser Gly Ser Leu Ser Ala 1010 1015 1020 aaa gag cgg tgg agc aag cgg gct cgg ccg cag cag gac ctg gcg cgg 3121 Lys Glu Arg Trp Ser Lys Ag Arg Pro Gln Gln Asp Leu Ala Arg 1025 1030 1035 1040 ctg gtg atg gag aag agg cag ggc cgc ctg ctg ttg cgg ctg gcc tca 3169 Leu Val Met Glu Lys Arg Gln Gly Arg Leu Leu Leu Arg 1010 tcg tcc tcc tcc agt gag gag cag cgc cgt gcc tct gag acc 3217 Gly Ala Ser Ser Ser Ser Ser Glu Glu Gln Arg Arg Ala Ser Glu Thr 1060 1065 1070 ctc tca ggc acg ggc tct gag gag gac acg ccc gcc tct gag ccgca 3265 Leu Ser Gly Thr Gly Ser Glu Glu Asp Thr Pro Ala Ser Glu Pro Ala 1075 1080 1085 gcg gcc ttg ccc agg aag agc ggg agg gca gcc gcc acc agg agc cgg 3313 Ala Ala Leu Pro Arg Lys Ser Gly Arg Ala Ala Ala Thr Arg Ser Arg 1090 1095 1100 att ccc cgc ccc att ggc ctc cgc atg ccc atg cct gtt gca gcc cag 3361 Ile Pro Arg Pro Ile Gly Leu Arg Met Pro Met Pro Val Ala Ala Gln 1105 1110 1115 1120 ca ccc gcc agc aga tcc cat ggc gcg gcc cca gca ttg gac aca gcc 3409 Gln Pro Ala Ser Arg Ser His Gly Ala Ala Pro Ala Leu Asp Thr Ala 1125 1130 1135 atc acc agc agg ctc cag ctg cag acg ccc cca ggg tcg gct 3457 Ile Thr Ser Arg Leu Gln Leu Gln Thr Pro Pro Gly Ser Ala Thr Ala 1140 1145 1150 gct gac ctc cgc ccc aaa caa cct cct ggc cgc ggc ctg ggc cca ggg 3505 Ala Asp Leu Arg Pro Lys Gln Pro Pro Gly Arg Gly Leu Gly Pro Gly 1155 1160 1165 cga gcc caa gcc gga gcc agg ccc cca gcg ccg cgc agc ccg cgc ctc 3553 Arg Ala Gln Ala Gly Ala Arg Pro Pro Ala Pro Arg Ser Pro Arg Leu 1170 1175 1180 ccc gcg tcc gca tcc cgc aat gcc agc gcg tcc ccc cgg agc 3601 Pro Ala Ser Thr Ser Ala Ala Arg Asn Ala Ser Ala Ser Pro Arg Ser 1185 1190 1195 1200 cag tcc ctg tcc cgc aga gag agc ccc tcc ccc tcg ca c cag gcc cgg 3649 Gln Ser Leu Ser Arg Arg Glu Ser Pro Ser Pro Ser His Gln Ala Arg 1205 1210 1215 ccc ggg gtc ccc ccg ccc cgg ggc gtc ccg ccg gcc cgg gcc cag cct 3697 Pro Gly Val Pro Pro Pro Arg Gly Val Pro Pro Ala Arg Ala Gln Pro 1220 1225 1230 gat ggc acc ccc tcc ccc ggg ggc tcc aag aaa gga ccc aga ggg aaa 3745 Asp Gly Thr Pro Ser Pro Gly Gly Ser Lys Lys Gly Pro Arg Gly Lys 1235 1240 1245 ctc cag gct cag cgc gca aca acc aaa ggc cgg gca gga ggc gcg gag 3793 Leu Gln Ala Gln Arg Ala Thr Thr Lys Gly Arg Ala Gly Gly Ala Glu 1250 1255 1260 ggc cgg gct ggg gcc aga taatgacgcc cgctgctctc cgcly Agg Acc Agcc Agcc AgAgcc AgAgcc AgAg Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag 1g Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Ag Atg Ag Atg Ag Atlg Ag Atlg Ag Atlg Ag Atlg Ag Atlg Ag Atlg Ag Atlg Ag Atlg Ag Atlg caccctcacc ccggcccccc acccgcagcc ggccacactg gagcagctcc cagcacagcc 3901 ttacgcgccc gacgcgcgcc acccgcggcc ccagctttcc gcctgcaccc gcgaggacgc 3961 gcgcgagcac acgcggcgcc ccgccaggcc ttagggcccg tgggggacgc ggccccgcgc 4021 cgcggggagg gtctgcctcc ccttcctcgc cctgtgtcct ctcatcctcc cgccgcccgt 4081 caggccggcc agcctcacat cagtctctcc gccccgggga aggctcagcc acttttcatc 4141 gaggact cca cttctgggga cgcctggttc gttcgcccac caggcctagg ctacgctcca 4201 tgctccccca gcaatctctg cctacacctc ctgcggcgcc ttgccctcct ccgacccctt 4261 tccagccaaa gtccccccac cccttcagag aagcagcctc aaattccaga agtggaggct 4321 ccagcctccc cgcgagggtc cagccccaca gtcttctggg agccattgtg gccagggacg 4381 gcctctggac tgccaggctg ggttggggac ccagggaaca tcggtctact caggtgtgag 4441 ggggcaggtc tgacctgccc caaagttggc tccatcctgg acaactcggt gagaggcagt 4501 gggcaagtga tcttggagat gggtgggcag gtgattctgt gggcagggga tgtgctcccc 4561 tgcacctctg gggtgcagaa acctcttgcc tccagatttg ggtggagcct ctgtgggaac 4621 cataggaagt gtgtgggctg ccttcctggg caagtatttc ccagtgggaa gttggagggg 4681 gctttaacaa agttttactc cctcccctgt tcccctgatc tagtgctcag gacccttcac 4741 catcaggaat tccttcctgt catctaacct cagtcctgcc tactgcagtt ccagccaacc 4801 tgctctttcc tgagttcaaa gcaggtggag actggctggt taccatcttt gcactggccc 4861 ttcggagatt cggggactca gttctggtgg ggtcaccctc cctgtcctcc cgcctgtggg 4921 agggagggag ggctggctca ggcatcgtct cccgcaatgg gcagagagag cagagacagg 4981 tggaccaaca g acagctggc ccctggaggc agaaaggccc ttctaacttc cagattgtat 5041 gcttgagtga tgggtcccca gcccaagccc actcttccct cagctcaccc ttcagcctgt 5101 tccttcttgc cctgacccca gcccgtgcag ctgctctact ccaggaatgg atgtggggac 5161 tcttcctggg ttctggctcc tgcatagctc accccacctc atcatgagcc tcaactgcct 5221 acatctgggg caagcagcac accggctgca gatgggacag ccagccctgc ctatctggac 5281 aggcccctgc agcctctgtc ccctggccta gcctctctgt ccttccctga gtcacagaga 5341 gcaagccaag acatccaggg aaagaggaag aaaggcctta gtgtgcccca gcagtctggc 5401 tgcgtccagc caccatcacc cggaaggatg cccacaaggc agctgaccct gaaagcagcc 5461 tccccctcat ggagagtcag cagcttgggc agccacttcc aggccagggt ggtggcttct 5521 ctgcagacca gctgagggga ggactcctgg gtggacagcc tttgacgtcc accccacgct 5581 gatgcagaag ctcccagaac actcaggaaa cttctccgga cagagccctc cttgtcaact 5641 tgaggccctc ccaaggccct ctactgccct ctgggtccag cagagggagt ggaggaaggg 5701 ccactgcctc ccacctagag cttctccgaa tgacaatcag ctcgtgccag gtggggacca 5761 ggatatgact cctggtgccc aggccctggg cctgctcctt gccaccaacc gaaccgtgaa 5821 tgtagggccc ccagcct cac ctctgcccca ggaccaacaa caccctggtt tggagctggg 5881 aggaagaagg gggcctgaga gagccccagg tccattctac ccccagcttc actcagcact 5941 ggagctggca gagacgcaaa acccagtctg cccttgggat tccaaacctc cctagggctc 6001 ccaactgacc tcaggcctct gagtcactga atgtcaccag gagaggtggg ggagggaaag 6061 tgggccagtg gggagggggt cacctagggg actgcctctg tgcctctccc caggaagcat 6121 ccagggcaga ggaagccaca tctcccggtg cccccaaccc cagctgcagc ctcctccccc 6181 tgagcattca ttctctccac caggcctcca ggtcctgagc ccttcctctg taaaagtgtc 6241 acaccacctc cctcagcact tccccatcac aacaacctat gtcactgact cagatgcagg 6301 gtctgctcac cccaacacat gccttccctc cccagccaca ccgtgcacga agggggcaca 6361 ggagaggaga ggggctgtgc cccaggctcc ccatttccca gctcctcaca gaggcctggt 6421 ttgctcagtc ttctgaactc cagggaccag ccctggtggg catggggtgg ggagcaggga 6481 gttgcccttc ccctccctcg ggaagccacc taagaatgtt tacatgccaa acagaatgta 6541 acacccctcc ccaagccctt cccagtcact gcatggcctc tgcccatcct gcacctgtcc 6601 accccacccc aacaccctgg aagccactgt caatgattag atcgggtctc ggaagggaag 6661 tagccatcac accattaaaa a gcctgtgga cctttt 6697 <210> 21 <211> 5851 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1055) .. (1390) <400> 21 atcacaaagg cggtgagact gcattcactt acaggttcct atttagggcc aagttgctct 60 gcctttccaa atcagcatgg gcctcaggcc ctggctcagc cctccaggct cgacttaccc 120 ggctgatgag ctgctcgccc gtctcggagg cagtgatgag tttgcaaagg gcttggaggg 180 caggattggg cagacctaaa ccaagaaaaa agggtagaag ttattcagaa gggcctctgc 240 acccaaaagc ctgccacctt cccaggggaa agaaccctaa atccttggca tcggtggcat 300 ttttcagaag ctcagcacag ctagacatgt gtgtctgtgt gtgccttgga aaaggacagc 360 gtggtctccc aggaaggtgg gtggaagtgg gttgagtcct gaccctgccg cagtcctcta 420 ggcgtggcca cactcccagg acccaggcag caccaccccg agtcaagcac ccagcttcac 480 cctggggttg gccgcacagc ttcatcgggg ccacagctgc tgatgacaat ggcagtagtg 540 gccagtgtct gccggaacga cctcccatca tcccgggaag gggcagcgcc agtggggcgc 600 agatgcctgc catcacagat ggaaacagca ggtaaatggc acttgtttcc tccaggtgtg 660 gagatgcttg tatctgggac cccctgccat ttctcaggac accctcctgc tcctagctgg 720 gagatccagc atcctcatga atgcggggcc caaggccacc aactgttcca cctgctgtca 780 gccaggcctg ttgccccagc cctacaccca cagctcaccc agcagggact ggagtgtgct 840 gctgcactgc tggagccggt cgcccgggtc ggaggttggg aagaagacag ccgctggcag 900 gccactggtt ggggggtcca gccggaagcc cacagcggtg aggagggcct gccagccagg 960 gatgccgccc actttgttct ccacactctg ctgggacgtg tacatggcat tgcgctgccc 1020 attctggatg cgctgcaggg atttctccac ctga ggg gga att ggg gta aac act 1075 Gly Gly Ile Gly Val Asn Thr 1 5 ggg atg ccg gag ctc agg cat ccc aga cag gag gaa gtg tgt act cac 1123 Gly Met Pro Glu Leu Arg His Pro Arg Gln Glu Glu Val Cys Thr His 10 15 20 acc agc cag gag gaa aca agc ctg cct ggg agg aca gac gat cag ccc 1171 Thr Ser Gln Glu Glu Thr Ser Leu Pro Gly Arg Thr Asp Asp Gln Pro 25 30 35 tgg ctg tcc ctc agg agc ggg ggg cct cca agg cac act gcc cac tgg 1219 Trp Leu Ser Leu Arg Ser Gly Gly Pro Pro Arg His Thr Ala His Trp 40 45 50 55 gtc aag gag tat cca gga gga gtt aga agc atg acc cat ctg cct ggc 1267 Val Lys Glu Tyr Pro Gly Gly Val Arg Ser Met Thr His Leu Pro Gly 60 65 70 acc agc acc tgg ggc tgc cag gca gcc acc cct gca gct gtg ttg aca 1315 Thr Ser Thr Trp Gly Cys Gln Ala Ala Thr Pro Ala Ala Val L eu Thr 75 80 85 gga cct ggc aga ggg act gac cca cct ttg gaa aat gac acc agc aat 1363 Gly Pro Gly Arg Gly Thr Asp Pro Pro Leu Glu Asn Asp Thr Ser Asn 90 95 100 atc agg atg tgt caa ctg gat tta tgt taagaaaata ggatttttgg 1410 Ile Arg Met Cys Gln Leu Asp Leu Cys 105 110 tgttcctctg tttcccaaag tttgagacac tttcagacac tctgctttgc ggttgtggcc 1470 gatgttaccc atgggtggga cttttgcttt gctctagatt tttgtaacac cctggggagt 1530 ttcaggggcc aatgctgaga gaagaccaca ggctgacaca tcatgaggtg cctaacttac 1590 tgagaatcat gcctgctgtg atgagccctt ggaaaccatc aggactggat ggtaggggtc 1650 ctgagaggat tgggggagga ggccttgata tgacagagtg gacagaggcc gtggaaccca 1710 ggacagccag cctgctccac aatcctcatc cccacagacc ttcatgtgtg gctcctaaat 1770 aagaggaaac ccactcctga taagtcaggg gctttgaaaa gtgattttgt ttaaatggtg 1830 caaacaagca agccaatctt ggggagacag ggctaaactt aagtccttta agaagctcta 1890 catactgaca agattctagt tcccttccac cttatatgct gcaaagtaaa aagtatcact 1950 gaatgagaaa atcagcataa agaagcccaa taatgtctgc ctgagtttcc cctatgatga 2010 cttttggtac tttttgggaa a cattaagta tgaagttatt tcaaaataat tttttggtgc 2070 ctctgcttgg tgttgcctta aactctgggt aagagaaaca ccaggtgcct gtcaggagat 2130 ggccttttcc aggtttctgg ttaagctaca aacagctaac tggctgctgt catcaaaata 2190 aaagctttct gaaggtggag gcatctgata cccagagtgc tgctatcagc cggcacggtg 2250 ggccgctggg tggcaggagc gtcgagaagg ccagctcgct tcctatctgg gattcagaat 2310 cagctatgga aacttgagag acctagagaa aataacttct ttcactttga actgattctt 2370 tgcttcataa gaaaagtatt atccagccac aaaaatggtc aaaattcaga tctacaaaag 2430 cctgtcaggc agaaactgac cccacttagg ccacgccaat gagcaagtca tcaaagcagc 2490 caagacaggt cctgtggggg ccacccatgc acagggccca gcctcgggtc ctaaccccgc 2550 ctatgctttc cgccaccata aagaggccca tctgggtaag acctgtcccg cctgctgtgg 2610 ggtattaggg cagatggggt ctgaggggtc tgagggctct gagagcagct ggcagctcaa 2670 ggacatccgg agttggagga tggagcaatg caggcccttg tggtaaagac agtcctgcag 2730 ccgcgcaggc agggatgctg caagtggagt gccaggcggg tgcggagccc tgtgggactg 2790 tggaggggtc agagggaagc caggattttg gggtctctga gagtttggag aaggggaaga 2850 agattaaagc ttgtttcaaa agtttct aat caggtgggca gggccaaggg tggctgtggg 2910 gtgagaccca tgactcaggg tggcccactg ttactctatt gatttttggg cgtttttttc 2970 caaattgatt attcttgctg aatgagacct gagtccttga ctgtcccctt aaagccccct 3030 gacttgtttt cagttccact ggcctgtcgg gctgttttct actcaactcc actcttgctt 3090 gtctgccctc cctgcctggg gcccagccag cagtcagctc aagggccaga tgaattgggt 3150 ggctgtgctc tgcccactgg gcatcgtgtg gatggtgggt gaccagcccc ctcaggtgct 3210 cagccaggcc tcaagccttg ctgtgtacct cagagcagct ctgtaccctg atgtcacagc 3270 aaagaaactt agacatgaca caaactgtgg cttcccaagg cagcaaagaa tggccagggg 3330 tcatgagggc cgtgccccac ttttggacag acctactcta aagtcacgct acctgcgtgc 3390 aaatcataaa atcaacactt ttgaggagat cacagctatg ccttcgtaac acagcccagt 3450 ccgaccagat agacggtgcc tcgtgacccg aaaacaagcc cccggccccc caccatgtgt 3510 gtgagcctta ccttggactg cacgctgagg gagcggatgg aagggacagc aaggaggccg 3570 aagcgctcgt agaggtactc attggaggag cttcccttca ggagggcgaa aggaatgagg 3630 tagagctccc cctccagaac caggatgagc tgccggtgcc ggcccacggg gccgctggag 3690 tgcatcaggc cctatggagc aagcacggag a ggctgacat gggtggccca gcaggcaggg 3750 ttttcaggca ccaggacaac cctgagccct agcctggatg acacaagcac gagcagagac 3810 aaatggcttc tctggaacat ccagctccga attttaaccc agagactatg agagacagag 3870 gtcgtcacat ccccctcacc tcatcttcac gtcaccatcg ctatcctcca cacctactta 3930 ctgagccacc accaagcagt taccctgaag tccagtttcc aagcccagag ttctcccagg 3990 caacccccaa tggatcccga atgtgtcttt gggtggtgaa ttctgattgg attgccgttt 4050 cggtcagcgg gaccttctgc atatgccctg gttgagtaca ggtcgagctc ttcagaaagc 4110 actcatagca aatgttatgt tgatcatgtc ctaatctgga gtttaagaaa gatgcgctcc 4170 ttgcgtatcg ccaaggttag aggatctgca ggtgacctcc gcggggcacc ggggagtttc 4230 ctttttactg gcagacacgg caggcctctc agggattcac agtatcacag gccagaggaa 4290 tgaaaatctc tgatcaccat gggggaggga aagaaaatgc ctgggtccat gagctttcag 4350 actgattaga cttgggatga aatggacttt actgtctaca ataaggattc cagaggcaaa 4410 gggcttcagg gtatccagat accccagaac tgtgtatagg gcttcacatt ttttcctgac 4470 tgatattttt gatggaataa atttatcaaa cagaactgtt taaggtagag gaaccctttc 4530 tgtgatgctg ctgggaaatc ctgtcatcat gggtgga tac atacagtttt ggcaaagatc 4590 acacacctcc tggaaatcac cctcaaccat aactgaagcc caccaagact gtagatactg 4650 tatttcagcc agaaatggaa aagcgaacat tcaacccatt caactgtatg ctttggccaa 4710 acaaccgccc actggtttgc ctgaagtacc taagaaggta ttggagaaac gtgaccaatg 4770 gccagcaaga gccagaaggg cctgcctgaa acccagggtc caacttcagc caaatcagct 4830 tgaagggact gttcaagctg caggagcctc tgtgcagtgg gcagggttgg aggggcggag 4890 gggagcctct ctctctatct tggctgacct ggtaaaaatg atccctccac ccctagtggc 4950 agaagaccct gacctgcctg gaacctgcca gggtaaggct aagatgtctg cttgttgaac 5010 accagctaga atagagccag cacgcagatg acactcatgt aacagcagcc atccaggtga 5070 gaatgccact taccacgtga gatcttgctg gttatcctgg gtgctgccac cactggtttt 5130 agtcatacag acagtttgca agtaattgcc tccatttttc ctcctcctaa tcagttgtga 5190 aaatgcttgt tgtccttggg tgatgtctgt cctcatttga atatcactac agatgtctca 5250 atcagaaatc aattagacag cctggtggtg gggctgccag tctcaaaggc ctcatcctct 5310 acctcatact ggaatctagg tctgattgtt tctaaggaca aaaattccct ggctataccc 5370 aagcctccca atctatttag aaaacaggca gccacgtggt c agtctcatt cctgttgcat 5430 ctgttctagg agaggccgac ttatcctgct acctgatttt gcaaggggta ttttacaaaa 5490 cacaagggag tcctttcccc cagggcagtg attacagtca tgacccaacc aaggccaagc 5550 cactctctag ctcggcagag ctagacccct gctttcactc ttagatgaga agtcttaggt 5610 gaaatccctg agctccagtg cttggaaagc agttcaacag cctaacagac ataaacaagt 5670 tttgaataag tttctaggat tttaaacagg tgactccaca cttcatgaat cacaagctga 5730 ggtgaatgag atgtactttt ctttctgatc aaagtcattt gctcttgcta cctgtcctag 5790 aaccttggtt tttaaattta aatacaggaa acagggaatt taaataaagg gaaataaaag 5850 t 5851 <210> 22 <211> 6118 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3468) .. (4982) <400> 22 cggcttgcca ggagctggag ggggaggtag gcggggcggc gcgtgaccta aggcctctct 60 gccgcgcgcg caggtacggg gcagaagtcg cagagccaag gcactgatgt ttgaactgga 120 aacttcaaaa cgtttaataa gagtcttcag gatgggtttg aactagacaa gctagaaatt 180 tctttagaac accagctcta gcatgcatct cccacttttg gctttcctgg agaggagctt 240 gaagaggtgg ttctgcagac agccacagtg atactcagga aaccagagga atggatttga 300 cttttctgct aggattcttt gttatagttt ctccctgagt tgtaagaggc atggaaatat 360 acatgaaact gaagaacctg caaggaaggg aagtggaact ttccatgctg agtgaaaact 420 aaccaagtgg cagttgtgac tgaaaacact gaaacctacc acgtccagat tcactggatt 480 gggggataga ggaacggtca cagctaggga gaaagaagtg ataccggaaa agaaaaccta 540 aatgaagaga atgaggatga ctgcacagta gatggccacc tctacctcca cagaggcaaa 600 gtcagcctcg tggtggaatt atttttttct ttatgatggt tccaaggtaa aggaagaagg 660 cgatccaaca agagctggca tttgttactt ttatccttcc cagaccctgc tagaccaaca 720 ggagttgctt tgtggacaga ttgctggagt tgtccgctgt gtttctgaca tttctgactc 780 tcctcctact cttgttcgtc tgagaaaact gaagtttgcc ataaaagttg atggagatta 840 cctttgggtg c tgggctgtg ctgtggagct ccctgatgtc agctgcaagc ggtttctgga 900 tcagctagtt ggattcttta atttttacaa tggacctgtt tccctagctt atgagaactg 960 ttctcaggaa gaactgagca cggagtggga caccttcatc gagcaaattc tgaaaaacac 1020 cagtgatctg cataagattt tcaattccct ctggaacttg gaccaaacta aagtggagcc 1080 cctgttgttg ctgaaggcag cccgcattct gcagacctgc cagcgctcgc ctcacattct 1140 cgctggctgc atcctctata aaggactgat tgtcagcacc caactcccgc cctccctcac 1200 cgccaaggtc ctgcttcacc gaacagcacc tcaggagcag gtattgtaaa gtccacccac 1260 ctggctggac agcatccccc agagcactgg tcactgagcc tgaggctgga gggatcagga 1320 gcagaggccg tggagcagtt gtttcacttg gtcttgtcag gaccccaagt cctccaatgt 1380 cattctcctc agtagtgaag ccattggtga ggctgaaaga aaatgttttc ttccacgagc 1440 taggcctgga tagttgtttt ttcttcaaac caaggaaatc ttggttgaat tcgacttccc 1500 ataagaattt gatgtctctt tatgtcaaag agatgttaga cttttcagag acagactgta 1560 aaggatgtgt ctttagaaag atttaggggg ttgggcacgg tggttcacac ctgtaatccc 1620 agcactttgg gtggctgagg tgggcagatc acttgaggtg aggagttcaa gaccagcctg 1680 gccaacatga tgaaaccc at ctctatttaa aatacaaaaa ttagctgggt gtggtggtgc 1740 acacctgtaa atcccagcta cttgggaggc tgaggcagga gaatcgcttg aacctggcag 1800 gcagaggttg aggtgagctg agatcgcgcc actgcactcc agcctgggta gcaagagtga 1860 gactctgtct caaaaaataa aaataaaaat aaaaaaataa ggaaaacaaa ctcttctaaa 1920 atacttccat tttatattta tttaattgtt tttatattga aaaaaaagcc atgcatgctc 1980 attgagaata aaattgccca tctttgaact gtacagggat agccactgcc agcatctggc 2040 atatctcctt ccagtccttt ttttgttttg tgtatgaagc tgtggtttcc agcgtatcat 2100 gaggctgtct ttttacacgt attagtgaac aggcatgtaa aatgctggta gggctctatt 2160 cagcctcctc agccactgtg gctatgggtg tcaattcgag tagcctttct gggaaacact 2220 ttgataatga gaacgttaag gatgcccttt atttttttcc taataatttg acttctagga 2280 atatatctta aggaaataat gtaactgctg aaaaaaattt atactcaaaa cttgatcaca 2340 acaagcttta tgaaagtgaa aaatcagaca aaacttgaat gcttaaagta ggaggtggca 2400 aattatggcc tgtgggccac ctgcctacaa atgaagtttt atttggctgc ttttgagcta 2460 taatagcaga accaagtagg tgggacagag accatatgcc ctgcaaagcc aaaaatattt 2520 actgtcttgt cttttgcaca gaa agtttac taattactgg tctaaggtag gtaaatgatt 2580 aatttactca tatcacttaa accttcataa aattttaatc agccgtttaa aatggccaaa 2640 gatgttttag tggcaggaaa tgcatgttac tgttttaagc agaaatatga aattttatat 2700 agtgtggcct caaaagtata aaaaatgcat aggcttaagg aaaaaatacc caatattaat 2760 agtactagct tggggatgag ggattgtatg tgattttttt tttcaacgct ttgtctagag 2820 taaattgagg ttaggcttag taatctaaaa catagttttt taaaaatcac caaaaaagga 2880 agaacaccat atcattctaa gattgaaagt cattttggct agaagagcag ttcttgtttg 2940 gtttggtttt gttttggtgg gttcttttgg aaccctcaga ttgagacgag agatgttttc 3000 atttttgaga aaatcatcag gttttaggcc ctgattgtga accagaacaa acgagagatt 3060 gggtatagca ttttgtttaa gtcaaatcct ttatcgtgag agtcacagta ttttgacatt 3120 tttattataa tggaatttat gtgaattcta catcagggct gtggcagatg tgactgtatt 3180 ctagaatatg agttccccaa aggtgtaaaa gagaacagga atcctcaatt ttattcccag 3240 aagggagaga gactgagaaa atcagaacgt agagtgtgat gtgagtttgg gtggagctgc 3300 tgccttgcag cctgtgtggg cccaggttct tgcttcatcc cagccatagt gggagccagc 3360 agcttggggg agcttctgtt ccatctgc tt ggctcttagc atgtggttgg gacaagcttt 3420 ctgggcctgg ctaagtttta tgaacagatg gcacagcaaa ttcctga tgg tta ggt 3476 Trp Leu Gly 1 caa gag gag aat gtg gtg ccc agc gcc aac ttc Tgt Gtg Gtl Gtt Asg Gt Gnt Ggt Ggt Gnt Ggt Ggt Ggt Phe 5 10 15 tca gag act ccc tac ggg agg gga tgc ccc gca gga aca tgg agc gca 3572 Ser Glu Thr Pro Tyr Gly Arg Gly Cys Pro Ala Gly Thr Trp Ser Ala 20 25 30 35 ttg ccc ccg aat gtc cag att atc cct gtt ttt gtg acc aaa gag gaa 3620 Leu Pro Pro Asn Val Gln Ile Ile Pro Val Phe Val Thr Lys Glu Glu 40 45 50 gcc att agt ctc cac gag ttc ccg gtg gaa cag atg aca agg tct cta 3668 Ala Ile Ser Leu His Glu Phe Pro Val Glu Gln Met Thr Arg Ser Leu 55 60 65 gca tct cca gca gga ctc cag gat ggt tca gcc cag cac cat cca aag 3716 Ala Ser Pro Ala Gly Leu Gln Asp Gly Ser Ala Gln His His Pro Lys 70 75 80 ggt ggg agc aca tct gcc ctg aaa gaa aac gcc act ggc cat gtg gaa 3764 Gly Gly Ser Thr Ser Ala Leu Lys Glu Asn Ala Thr Gly His Val Glu 85 90 95 tcc atg gcc tgg acc ac c cca gat ccc aca tcc cct gac gaa gct tgt 3812 Ser Met Ala Trp Thr Thr Pro Asp Pro Thr Ser Pro Asp Glu Ala Cys 100 105 110 115 cca gat ggc agg aag gag aac gga tgc ttg tct ggc cat gat ctg gag 3860 Pro Asp Gly Arg Lys Glu Asn Gly Cys Leu Ser Gly His Asp Leu Glu 120 125 130 agc atc agg ccc gca gga ctg cac aac tct gcc agg ggt gag gtt ctt 3908 Ser Ile Arg Pro Ala Gly Leu His Asn Ser Ala Arg Gly Glu Val Leu 135 140 145 ggc ctc agc tcc tcc ctg ggg aag gaa cta gtc ttt ctc caa gaa gaa 3956 Gly Leu Ser Ser Ser Leu Gly Lys Glu Leu Val Phe Leu Gln Glu Glu 150 155 160 ctc gac ttg tct gaa atcag gct cag gaa gtg gaa atg 4004 Leu Asp Leu Ser Glu Ile His Ile Pro Glu Ala Gln Glu Val Glu Met 165 170 175 gcc tca ggt cat ttt gcc ttc cta cat gtg cct gtt cca gat ggc agg 4052 Ala Ser Gly His Phe Ala Phe Leu His Val Pro Val Pro Asp Gly Arg 180 185 190 195 gct cct tac tgc aag gca tct ctc agc gcc tcc agc agc ctg gaa ccc 4100 Ala Pro Tyr Cys Lys Ala Ser Leu Ser Ala Ser Ser Ser Leu Glu Pro 200 205 21 0 acg cct cct gag gac aca gcc atc agc agc ttg cgc cct ccc tct gct 4148 Thr Pro Pro Glu Asp Thr Ala Ile Ser Ser Leu Arg Pro Pro Ser Ala 215 220 225 cct gag atg ctg acc cag cat gga gcc caa gag cag ctc gaa gac cat 4196 Pro Glu Met Leu Thr Gln His Gly Ala Gln Glu Gln Leu Glu Asp His 230 235 240 cct ggc cat agc agc caa gcc ccc att ccc aga gca gac cct ctc ccc 4244 Pro Gly His Ser Ser Gln Ala Pro Ile Pro Arg Ala Asp Pro Leu Pro 245 250 255 aga agg acc cgc agg ccc ttg tta ttg cct cgc tta gat cca gga cag 4292 Arg Arg Thr Arg Arg Pro Leu Leu Leu Pro Arg Leu Asp Pro Gly Gln 260 265 270 270 275 aga gga aac aag ctt ccc acg ggg gaa caa ggc ctg gat gag gat gtt 4340 Arg Gly Asn Lys Leu Pro Thr Gly Glu Gln Gly Leu Asp Glu Asp Val 280 285 290 gat ggg gtc tgt gaa agc cac gca gcc cct ggt ctg gcatc 388 Gly Val Cys Glu Ser His Ala Ala Pro Gly Leu Glu Cys Ser Ser 295 300 305 ggc tca gca aac tgt cag ggt gct ggc ccc tct gca gat gga atc agc 4436 Gly Ser Ala Asn Cys Gln Gly Ala Gly Pro Ser Ala Asp Gly Ile Ser 310 315 320 tcc agg ctg aca cca gca gag tcc tgc atg ggg ctc gtg agg atg aat 4484 Ser Arg Leu Thr Pro Ala Glu Ser Cys Met Gly Leu Val Arg Met Asn 325 330 335 ctc tac act cac tgc gtc aaa ggg gt atg ctg tcc ctg ctg gct gag 4532 Leu Tyr Thr His Cys Val Lys Gly Leu Met Leu Ser Leu Leu Ala Glu 340 345 350 355 gag ccg ctg ctg gga gac agc gca gcc ata gag gaa gtg tac cac agc Leu Glu Pro Glu Asp Ser Ala Ala Ile Glu Glu Val Tyr His Ser 360 365 370 agc ctg gct tca ctg aat ggg ctg gaa gtc cac ctg aaa gag acg ctg 4628 Ser Leu Ala Ser Leu Asn Gly Leu Glu Val His Leu Lys Glu Thr Leu 375 380 380 385 ccc agg gat gag gca gcc tcc acg agc agc acc tac aac ttc aca tat 4676 Pro Arg Asp Glu Ala Ala Ser Thr Ser Ser Thr Tyr Asn Phe Thr Tyr 390 395 400 tac gac cgc att cag agc ttg ctg atg gca aac ctgg gtg gcc 4724 Tyr Asp Arg Ile Gln Ser Leu Leu Met Ala Asn Leu Pro Gln Val Ala 405 410 415 acc ccg cat gat cgc cgc ttc ctc cag gcc gtc agc ctg atg cat agc 4772 Thr Pro His Asp Arg Arg Phe Leu Gln Ala Val Ser Leu Met His Ser 420 425 430 435 gaa ttt gcc cag ctg ccc gcg ctt tat gaa atg act gtc aga aat gcc 4820 Glu Phe Ala Gln Leu Pro Ala Leu Tyr Glu Met Thr Val Arg Asn Ala 440 445 450 tcc acg gct ggt tac gcc tgt tgc aac ccc atc cag gag aca tat ttc 4868 Ser Thr Ala Val Tyr Ala Cys Cys Asn Pro Ile Gln Glu Thr Tyr Phe 455 460 465 cag cag ctg gca cct gca gca cgg agc tcc ggc ttc cca acac cct Gln Gln Leu Ala Pro Ala Ala Arg Ser Ser Gly Phe Pro Asn Pro Gln 470 475 480 gat ggc gcc ttc agc ctc tcc ggc aaa gca aag cag aag ctg ctg aag 4964 Asp Gly Ala Phe Ser Leu Ser Gly Lys Ala Lys Gln Leu Lys 485 490 495 cac ggg gtg aac ttg ctc tgaactgcac ccaggaggtg actgggaagg 5012 His Gly Val Asn Leu Leu 500 505 agaaaaccag caaaggaagc tctgcctttt ataattgaaa aggcccctct attttatttt 5072 tcttgaaaac attccctttt ttaggaacca aatgatattt gagtttttgt tattcctttt 5132 gcagattggg atgtgttttg ggggcagggg ttagttcttc aggtcggcag acccagagca 5192 cttgataaag aactgtattt aatcggtagt gttggggccg ggacgggctt ggctccctct 52 52 ctgccatact gagcctgagg tatttcatat ctcctgctgt tccatcccag cttgaattgg 5312 tgccacaagc ttccaagttg gcattttttc tagaacctga tcgtccacta gcccagagtg 5372 tgtgtgttca acccccacac caggtggtgg taggcggtgt gactgcacag cgaggtgccg 5432 gatctgtgag caggccgact ccactcccac gccgcaggta ggtttctcca gtgcgctctt 5492 gctgggaggt ccggatcgtt cctgcaggga agcggcagca cacggagacc acttggttga 5552 attctgttgg aactctactc aaatctaggg gcgtcttctt tggacccaca atgggggcaa 5612 gccttaataa tatggaaggg agtttgggct ttagagatcc ctttataaaa gctctggggg 5672 ctgagccctg agaattcagt gacaacagga ccaacctgcg ctgcctttga ctacaagtgg 5732 gccgtgcagc tggttcctct cgagcgagtg tccctaaata ggagtttaca agatgtctgg 5792 gggtaaaagc actgtgcttt tcagtggtgg ctgcgtgaaa gggagcgaca ctcagctgtg 5852 tgttcctggg cttgtgtggt acttagaacc tcagttctat tacgttatag tcagacattt 5912 ttttgacagt atgagacaga ctgcaggatg aaaatatttg tcaaaatctt aactgaatgt 5972 ttactggaag tacttgagat tccatttgag agttgtattg ttaataattt catgtcagtg 6032 aactgatatc tgatgtttat gatatggtgt ctttttcttg aaacaagctt ccaagggcta 6092 gaa ataaaat agccaaaaaa tgctgg 6118 <210> 23 <211> 6957 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2026) <400> 23 c acg gcg cct ccc acg ttc ccc gca ctc acc ccc ggc ttc ccg ggc atc 49 Thr Ala Pro Pro Thr Phe Pro Ala Leu Thr Pro Gly Phe Pro Gly Ile 1 5 10 15 ttc cct cca tcc ttg tac ccc cgg ccg cct ctg cta cct ccc aca ccg 97 Phe Pro Pro Ser Leu Tyr Pro Arg Pro Pro Leu Leu Pro Pro Thr Pro 20 25 30 ctg ctc aag agc ccc ctg aac cac acc cag gac gcc aag ctc ccc agt 145 Leu Leu Lys Ser Pro Leu Asn His Thr Gln Asp Ala Lys Leu Pro Ser 35 40 45 ccc ctg ggg aac cca gcc ctg ccc ctg gtc tcc gcc gtc agc aac agc 193 Pro Leu Gly Asn Pro Ala Leu Pro Leu Val Ser Ala Val Ser Asn Ser 50 55 60 agc cag ggc acg acg gca gct gcg ggg ccc gag gag aag ttc gag agc 241 Ser Gln Gly Thr Thr Ala Ala Ala Gly Pro Glu Glu Lys Phe Glu Ser 65 70 75 80 cgc ctg gag gac tcc tgt gtg gag aag ctg aag acc agc agc gac 289 Arg Leu Glu Asp Ser Cys Val Glu Lys Leu Lys Thr Arg Ser Ser Asp 85 90 95 atg tcg gac ggc agt gac ttt gag gac gtc aac acc acc acg ggg acc 337 Met Ser Asp Gly Ser Asp Phe Glu Asp Val Asn Thr Thr Thr Gly Thr 100 105 1 10 gac ctg gac acg acc acg ggg acg ggc tcg gac ctg gac agc gac gtg 385 Asp Leu Asp Thr Thr Thr Gly Thr Gly Ser Asp Leu Asp Ser Asp Val 115 120 125 gac agc gac ctt gac aag gac aag ggc aag ggc aag tcc gcc gag ggc 433 Asp Ser Asp Leu Asp Lys Asp Lys Gly Lys Gly Lys Ser Ala Glu Gly 130 135 140 cag ccc aag ttt ggg ggc ggc ttg gcg ccc ccg ggg gcc ccg aac agc 481 Gln Pro Lys Phe Gly Gly Gly Gly Pro Gly Ala Pro Asn Ser 145 150 155 160 gtg gcc gag gtg cct gtc ttc tat tcc cag cac tca ttc ttc ccg cca 529 Val Ala Glu Val Pro Val Phe Tyr Ser Gln His Ser Phe Phe Pro Pro 165 170 175 ccc gac gag cag ctg ctg act gca acg ggc gcc gcc ggg gac tcc atc 577 Pro Asp Glu Gln Leu Leu Thr Ala Thr Gly Ala Ala Gly Asp Ser Ile 180 185 190 aag gcc atc gca tcc att gcc gag aag tac ttt ggc ccc ggc ttc atg 625 Ala Ile Ala Ser Ile Ala Glu Lys Tyr Phe Gly Pro Gly Phe Met 195 200 205 ggg atg cag gag aag aag ctg ggc tcg ctc ccc tac cac tcg gcg ttc 673 Gly Met Gln Glu Lys Lys Leu Gly Ser Leu Pro Tyr His APhe 210 215 220 ccc ttc cag ttc ctg ccc aac ttc ccc cac tcc ctt tac ccc ttc acg 721 Pro Phe Gln Phe Leu Pro Asn Phe Pro His Ser Leu Tyr Pro Phe Thr 225 230 235 240 gac cga gcc ctc gcc cac aac ttg ctg gtc aag gcc gag cca aag tca 769 Asp Arg Ala Leu Ala His Asn Leu Leu Val Lys Ala Glu Pro Lys Ser 245 250 255 ccc cgg gac gcc ctc aag gtg ggc ggc ccc agt gcc gag tgc ccc ttt 817 Pro Arg Asp Ala Leu Val Gly Gly Pro Ser Ala Glu Cys Pro Phe 260 265 270 gat ctc acc acc aag ccc aaa gac gtg aag ccc atc ctg ccc atg ccc 865 Asp Leu Thr Thr Lys Pro Lys Asp Val Lys Pro Ile Leu Pro Met Pro 275 280 285 aag ggc ccc tcg gcc ccc gca tcc ggc gag gag cag ccg ctg gac ctg 913 Lys Gly Pro Ser Ala Pro Ala Ser Gly Glu Glu Gln Pro Leu Asp Leu 290 295 300 agc atc ggc agc cgg gcc cgt gcc agc caa agc gag 961 Ser Ile Gly Ser Arg Ala Arg Ala Ser Gln Asn Gly Gly Gly Arg Glu 305 310 315 320 ccc cgc aag aac cac gtc tat ggg gaa cgc aag ctg ggc gcc ggc gag 1009 Pro Arg Lys Asn His Val Tyr Gly Glu Lyg Leu Gly Ala Gly Glu 325 330 335 ggg ctg ccc cag gtg tgc ccg gcg cgg atg ccc cag cag ccc ccg ctc 1057 Gly Leu Pro Gln Val Cys Pro Ala Arg Met Pro Gln Gln Pro Pro Leu 340 345 350 350 cac tac gcc aag tcc ccc ttc ttc atg gac ccc atc tac agg gta 1105 His Tyr Ala Lys Pro Ser Pro Phe Phe Met Asp Pro Ile Tyr Arg Val 355 360 365 gaa aag cgg aag gtc aca gac ccc gtg gga gcc ctg aag gag aag tac 1153 Glu Lys Arg Lys Val Thr Asp Pro Val Gly Ala Leu Lys Glu Lys Tyr 370 375 380 ctg cgg ccg tcc ccg ctg ctc ttc cac ccc cag atg tca gcc ata gag 1201 Leu Arg Pro Ser Pro Leu Leu Phe His Pro Gln Met Ser Ala Ile Glu 385 390 395 400 acc atg aca gag aag ctg gag agc ttt gca gcc atg aag gcg gac tcg 1249 Thr Met Thr Glu Lys Leu Glu Ser Phe Ala Ala Met Lys Ala Asp Ser 405 410 415 ggc agc tcc ctg cag ccc ccc ccc cac ttc aac ttc cgg tcc 1297 Gly Ser Ser Leu Gln Pro Leu Pro His His Pro Phe Asn Phe Arg Ser 420 425 430 cca ccc cca acg ctc tcc gac ccc atc ctc agg aag ggc aag gag cga 1345 Pro Pro Pro Thr Leu Ser Asp Pro Ile Leu Arg Lys Gly Lys Glu Arg 435 440 445 tac acg tgc agg tac tgt ggg aag atc ttc ccc aga tca gcc aat ctc 1393 Tyr Thr Cys Arg Tyr Cys Gly Lys Ile Phe Pro Arg Ser Ala Asn Leu 450 455 460 460 acc aga cac ctg agg acg cac act ggg gag cag ccg tac agg tgt aag 1441 Thr Arg His Leu Arg Thr His Thr Gly Glu Gln Pro Tyr Arg Cys Lys 465 470 475 480 480 tac tgc gac cgc tcc ttc agc atc tct tcg aac ctc cac cac gtc 1489 Tyr Cys Asp Arg Ser Phe Ser Ile Ser Ser Asn Leu Gln Arg His Val 485 490 495 cgg aac atc cac aac aag gag aag cct ttc aag tgc cac ctg tgc aac 1537 Arg Asn Ile His Asn Lys Glu Lys Pro Phe Lys Cys His Leu Cys Asn 500 505 510 cgc tgc ttc ggg cag cag acc aac ctg gac cgg cac ctc aag aag cac 1585 Arg Cys Phe Gly Gln Gln Gln Thr Asn Leu Asp Arg His Leu Lys Lys His 515 520 525 gag cac gag aac gca gtg agc cag cac ccc ggg gtc ctc acg aac 1633 Glu His Glu Asn Ala Pro Val Ser Gln His Pro Gly Val Leu Thr Asn 530 535 540 cac ctg ggg acc agc gcg tcc tct ccc acc tca gag tcg gac aac cac 1681 His L eu Gly Thr Ser Ala Ser Ser Pro Thr Ser Glu Ser Asp Asn His 545 550 555 560 gca ctt tta gac gag aaa gaa gac tct tat ttc tcg gaa atc aga aac 1729 Ala Leu Leu Asp Glu Lys Glu Asp Ser Tyr Phe Ser Glu Ile Arg Asn 565 570 575 ttt att gcc aat agt gag atg aac caa gca tca acg cga aca gag aaa 1777 Phe Ile Ala Asn Ser Glu Met Asn Gln Ala Ser Thr Arg Thr Glu Lys 580 585 590 cgg gcg gac atg cag atc gtg gac agt gcc cag tgt cca ggc cta 1825 Arg Ala Asp Met Gln Ile Val Asp Gly Ser Ala Gln Cys Pro Gly Leu 595 600 605 gcc agt gag aag cag gag gac gtg gag gag gag gac gac gat gac ctg 1873 Ala Ser Glu Lys Gln Asp Val Glu Glu Glu Asp Asp Asp Asp Leu 610 615 620 gag gag gac gat gag gac agc ctg gcc ggg aag tcg cag gat gac acc 1921 Glu Glu Asp Asp Glu Asp Ser Leu Ala Gly Lys Ser Gln Asp Asp Thr 630 630 630 gtg tcc ccc gca ccc gag ccc cag gcc gcc tac gag gat gag gag gat 1969 Val Ser Pro Ala Pro Glu Pro Gln Ala Ala Tyr Glu Asp Glu Glu Asp 645 650 655 gag gag cca gcc gcc tcc ctg gcc gtg ggc ttt gac ca c acc cga agg 2017 Glu Glu Pro Ala Ala Ser Leu Ala Val Gly Phe Asp His Thr Arg Arg 660 665 670 cat atg caa tgatgctgtc cctttccgaa gacactcctc tccacacccc 2066 His Met Gln 675 ctcccagggt tctctggacg cttggttgaa ggtcactgga gccacgtcgg agtctggagc 2126 atttcacccc atcaaccacc tctgacgggc tgggcagccg ggggccggtg gccagagcga 2186 gggcaccagc cacgaaggac ggaggcgggc ggggccccgg agaaccctgt ccctgcgtgt 2246 ggccactcct cagcatcctc cccacccacc atggttcatt ccgacttttc caatggaaac 2306 tcagatccca aaagtcccta aagcagtcgt agagtctcac catctccaag gattggtctt 2366 gagaacactg ttcagtgacg gccatgcagg tggccgtcca aagacagcca acggagctgc 2426 ctcgcagaat cagccagtgg gcaggtggac gctctgctga gacagaagct ggtggccact 2486 gccgggtgcc cgcgtggggt cgcggaaggg aatggataga ctggtgtgct caaaagagag 2546 agatcactca aatgattttt ataatgaaat gacaagaata acccttttgg taaccgtatt 2606 gactgcagag tctatttaag catgtggttt taaaaataga cagtattttt taaaaatcaa 2666 aaaatgactt gcaaattgtt ttttaaaagt aattttgcat tgctttgaaa tttgagctca 2726 tttgcaaacc cgagtctgcc tgggaacccg cactgtgcct ggg tgtattc tttatactgt 2786 agataatgga gaaattttct atctctgtcc ctatttgtat aagccaaggt gatgctgggt 2846 gccccgaggc agaacaagag gcgcggggcc acacccgtga accatgcaga cggccgaaga 2906 agtcttaggc agggcgccct gggctgcagg cctgcccgag gctgggatgg gaagtgtgcc 2966 tgccctcgtg tgacatggaa ttggtgtcag gaccgccacg tggccttcag aggaatccac 3026 aggtccccac ccaagatccc tcaattatat ggggaagtcg agggcctgtg gcttggatcc 3086 gccatgcaga gatgtggccg ggcacccatc ttccttccct cctctgtccc tgcctcggcc 3146 accccacgcg ggaacccagc gccgtcctct gaaggcaggg ccttggccac gtcctgggtc 3206 tcccacctcc cacctgaccc cagcggctcc ggtgtcctcc acgtggctgc cctggggagc 3266 aatcccagcg gatcgctccg ggccaccaag ccgcacctgt gcctgagact ccggatggac 3326 gacacagtcg tcacgtcgct cttcctgcgg gttcttggcg agacacagct tgagaacaga 3386 agggcgtcgg gggaacctgc cgcaaggagc agagacagca cagccccccg ggcccagccg 3446 cctccctctc ttgggacgca acttcttccc cactcggatg ggctttaaat tattcccata 3506 ggggccaatt tcaaataata atttttttcc ctgatggaat ttaccttaat ctgtatataa 3566 cttgtaattt tttctaattc atttcttttc ttattttatt tcctcctt aa cagtattttt 3626 ggcattagac attcttattg tgaagaaata atgttaatat aagtatctgg tgaaggacca 3686 aaaccgtgtg ataaggttgt gtgtcgtgtg ggagtggggc gattttttat gtgccaaata 3746 cccccgtccc ccccatgaat cctgctgtcc ctgctgccgt ttaccagaca atcatatgtt 3806 tttgttaaat ttgcgtttca gttacatttg catttaagac aagtgttcta tttatttctt 3866 gtattgtttg gaagaaaaaa tgatgataga gtcccaaaaa gaagagaaaa aaaatgccca 3926 agttgccctt taaaaaaaaa gagcgtaaat acaaacagga gtggtgcaag ccgccttggt 3986 gtgggtttgt gtcacgcgtg gacatctcct caggctttgt gtcacgcgtg gacatctcct 4046 caggctgtcc ccagcggtga cgggaggtgt cctggctgct ccaggacaaa agacaatcgt 4106 ctctgtgggt gccgggcggt ccaggcttgc actgaagacg tgccacgggg aggctcctgc 4166 aggaggctca acccgacgga tcacagtgaa agggattcct cccacgccag atctgcacaa 4226 cgaggcaaga caggacccac ctgtgcgtgc gctggggcca tggggtggcc cccccggggc 4286 agcgggggag ctgcctgcag aagagccagc cggcgtgtcg ggaaggatcc aggatctgca 4346 aacacaaccg ctcaggcctt ctcacgcgtt tccacaacat cccctgggtc agacccacca 4406 ggtaccccgt aggaatttcc agtttccctt gatctagatg ggattcttat aaa aattcaa 4466 cctcagacat aaacacccca tttctgtaaa cccaaattat atggtttctt ctgcgaaaga 4526 gtaaggtgtg tgcttttttt tttgcaatat ggccccgtct ctctgaagtg ggacattcgg 4586 acggatggag ccctcagcgt gtcttttcag caggagcaga accgatgaga gccgccctta 4646 ccgttggtct ccggatcccc cagtcccatc ccgccgtttt cggctgtctt cctaaccgtc 4706 ctgtcttctc ttggcgctct ttccttccac ctttcccaag agtcctggtt gcacgtttta 4766 agtcatatat tttcgtcccc ctgaaaatga tggcaagccc agtttctcct gagcattcag 4826 acccccaggc cccagcactt ggcgttttca ggaggccctg ttcttagagc ccctgacaaa 4886 ggcagcactt atttcctggg ctggtgcgcc ccaaaacacg gccccgacac ttagtgtggc 4946 cccaggcccc agcgagcctc gccctcccag ttttgctctg cccagcagtg ttggtgccca 5006 gagatgacaa gggccaggga gcctggcccg ggtgtgagaa ttcagagatt ctggcctcca 5066 gctgtcacca caccgtaacg gggccatgta actgtgcagc atggacaggg atgcgacggg 5126 gcagctggct gtgtccatgg ccaggtggcc agggtcaggg ctgcaagcca ggggtccagg 5186 gcccttccgt tcagcccaaa tgctgcccca atgctaactc cttggattgt caacccccat 5246 cccccaaatg gaaattccga aggaggcctc ctcgcacctg ccctccgctg ctcctcag ac 5306 cccagccccc agcgagccga cgtccccacc cgttcctgct ctcatcccca ggttgggcac 5366 gtggggttcc tcctctgtgg gcctggcaga cccttcatga gtgggaccca agatatcact 5426 gacttcaacc cagaggatcg agcccctgca ccctgcctgg ggccctgggg tgtggagcag 5486 tggctggggt gggcgtggtg tggcctgaga gactgcccag ctggagaggc cttcctttac 5546 aaggccacgc gtgcagctgt cccatccaga ccccgactgg ccaagacctc cacgtcccca 5606 gagtccagcc ctggaaattc caagggccct ggcgtcctct gccttccccg cttccccgtg 5666 agcgtctgca aaacacttgc ctgaatacat atcacgtatt ttagactcga agcctcgaag 5726 cactggattg tggtcccctg ccccctctgt cccgtccccc tgcccaagtg actgaaacct 5786 actgagctat attcactgtg ctgtcctagg gggagggaga gcagagctcg cccctgcact 5846 gcagccttgt gggggagggc aaggctctcc tcccagccag ggacgccagg acatagctgc 5906 tcctggtcag tggaggtcag ccgggtatca aaagccatga aactgtgtct ctgtagcaat 5966 gagtgatact gtgacaaaac catccttgca ttcttcctag aagagttcct ctgctccttc 6026 cattccattt ttgtgtttgt tttgttcttt tctgtcactg atccgtatta ccacttttgg 6086 aaaaaaataa ataaataaat aaataaaagg cagcttgagt ttccaaacgt gtgattcact 61 46 tgtgaacaaa agtcattcta acaattgcct tcagcgtcac gtgcattgcc actgcgcttt 6206 cggcacgagg gatgctgagc cctggtgtca gagtcgtaat ttaaagcgtg tgtgtatatg 6266 gactttgtcc cttaaggtcg atataaagaa tcctcgcaga atcacagacc tgtgccgccc 6326 gccaccttct gccattgtta cattacagat ttggtttagt ttcgttttgt tttgtttttt 6386 ctcttagaac tgtatagtat tgaaaaagaa atcaaatgta aatgtctggt tttcatataa 6446 tgtttaaaaa gaccattgag aaggaggctg gcgctcgccc catgtccccc ttgattgtaa 6506 attgcttctg ttctgtttat aagtaaactg tgcatgactc ctgcttagcg gtcattatcg 6566 tgtctgttgg tgaaattttt attaaaagga aaattctgta gatgcactta ttgaatatgt 6626 gattaggatc tacgtctgag actaggagtc ctgaactgct gacgcgaaag aggcgcagtt 6686 cccaattaat acggaaatcg ctgtgggaga agaatgaaat aagacgtgaa gtgtaggaaa 6746 tcatgaaaag aacaattttg caaattgcat tctgatgctt gtgatgaaca caaatgtact 6806 tgtgtagaga catttcctta agagaaagcc taggagaagc cgatttggag gttaatgctg 6866 tagaatagga ctgtatacca aatgtaatct ttccaatgct ccaatgaatt tatacatgag 6926 attgatatgc aataaatctg tgtgcttttc t 6957 <210> 24 <211> 5951 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (73) .. (3387) <400> 24 cacactctgg ggaggggctc ctttgcctgc tcagttgggg aagggacaga ctcataaact 60 caagtgcagt ga gat ggg aga aga agt tgt cca tgt tca cac tgg gtg aag 111 Asp Gly Arg Arg Ser Cys Pro Cys Ser His Trpg ag acc act gag tcc tcc atg aag aag ctg gcc 159 Glu Ala Glu Thr Thr Asp Met Thr Glu Ser Ser Met Lys Lys Leu Ala 15 20 25 tcc acc ctg ctg gac gcc atc acc gat aag gac ccc ctg gtg cag gag 207 Ser Thr Leu Leu Asp Ala Ile Thr Asp Lys Asp Pro Leu Val Gln Glu 30 35 40 45 cag gtc tgc agt gcc ctg tgc tcc ctc ggg gag gtg cgg ccg gtg gag 255 Gln Val Cys Ser Ala Leu Cys Ser Leu Gly Glu Val Arg Pro Val Glu 50 55 60 acg ctc cgt gcc tgc gag gag tat ctg cgg cag cat gac aag ctg gca 303 Thr Leu Arg Ala Cys Glu Glu Tyr Leu Arg Gln His Asp Lys Leu Ala 65 70 75 cac cca tac cga gca gcg gtc ctg agg gcc atgag agg gtc ctg agc 351 His Pro Tyr Arg Ala Ala Val Leu Arg Ala Met Glu Arg Val Leu Ser 80 85 90 agt cgc gcc agt gag ctg gac aag gac aca gcc agc acc atc atc ctc 399 Ser Arg Ala Ser Glu Leu Asp Lys Asp Thr Ala Ser Thr Ile Ile Leu 95 100 105 ctg gcc tcc agc gag atg acc aag acg aag gac ctg gtc tgg gac tgg 447 Leu Ala Ser Ser Glu Met Thr Lys Thr Lys Asp Leu Val Trp Asp Trp 110 115 120 125 cag cag gcg gcg agt ggc gtc ctg gtg gcc gtg gga aga cag ttc atc 495 Gln Gln Ala Ala Ser Gly Val Leu Val Ala Val Gly Arg Gln Phe Ile 130 135 140 agc aag gtg atg gag gag ctg ctg cg cg cg cc cg cg cg cg cg cg cg cg cg cct ggg acc ctg 543 Ser Lys Val Met Glu Glu Leu Leu Arg Arg Leu His Pro Gly Thr Leu 145 150 155 cca cac tgc gcc gtg ctg cac acc ctc gcc agc ctc tcg gtg gcc aac 591 Pro His Cys Ala Val Leu His Thr Leu Ala Ser Leu Ser Val Ala Asn 160 165 170 gcg ttc ggc gta gtc ccc ttc ctg cca tcc gtc ctg agc tcc ctg ctg 639 Ala Phe Gly Val Val Pro Phe Leu Pro Ser Val Leu Ser Ser Leu Leu 175 180 185 ccc gtg ctg gtg gcc aag cag gac acg gtg cgc gtg gcc ttc tgc 687 Pro Val Leu Gly Val Ala Lys Gln Asp Thr Val Arg Val Ala Phe Cys 190 195 200 205 tcc gct ctg cag cgc ttc agc gag ggt gcc ctg ag cac gcc S er Ala Leu Gln Arg Phe Ser Glu Gly Ala Leu Glu Tyr Leu Ala Asn 210 215 220 ctg gac cga gcc cca gac ccc acg gtc agg aag gac gcc ttt gcc acc 783 Leu Asp Arg Ala Pro Asp Pro Thr Val Arg Lys Asp Ala Phe Ala Thr 225 230 235 gac atc ttc agc gcc tac gat gtt ctc ttc cat cag tgg ctg cag agt 831 Asp Ile Phe Ser Ala Tyr Asp Val Leu Phe His Gln Trp Leu Gln Ser 240 245 250 cga gaa gcc aag ctc cgt ctt ggt gtg gag gct ctg ggg cct atg 879 Arg Glu Ala Lys Leu Arg Leu Ala Val Val Glu Ala Leu Gly Pro Met 255 260 265 agc cat ctg ctg ccc agt gag agg ctg gaa gag cag ctg ccc aag ctc 927 Ser His Leu Leu Glu Arg Leu Glu Glu Gln Leu Pro Lys Leu 270 275 280 285 ctc cct ggg att ctc gcc ctc tac aag aag cac gca gag acc ttc tac 975 Leu Pro Gly Ile Leu Ala Leu Tyr Lys Lys His Ala Glu Thr Phe Tyr 290 295 ttg tcc aag agc ctg ggc cag atc ctc gag gca gct gtg agt gtg ggc 1023 Leu Ser Lys Ser Leu Gly Gln Ile Leu Glu Ala Ala Val Ser Val Gly 305 310 315 agc cgc aca ctg gag acc cag ctg gat gccctg cac 1071 Ser Arg Thr Leu Glu Thr Gln Leu Asp Ala Leu Leu Ala Ala Leu His 320 325 330 tcc cag atc tgt gtg cct gtg gag tcc tca agc ccc ctg gtg atg agt 1119 Ser Gln Ile Cys Val Pro Val Glu Ser Ser Ser Pro Leu Val Met Ser 335 340 345 aac cag aag gag gtg ctg cgc tgc ttc act gtg ctg gcc tgc agc tcg 1167 Asn Gln Lys Glu Val Leu Arg Cys Phe Thr Val Leu Ala Cys Ser Ser 350 355 360 365 cct gac cgcta gcc ttc ctg ctg ccc agg ctg gac acc agc aat 1215 Pro Asp Arg Leu Leu Ala Phe Leu Leu Pro Arg Leu Asp Thr Ser Asn 370 375 380 gag agg acc cgc gtg ggc acc ctg cag gtg gtc aga cat ac gac atc ag Thr Arg Val Gly Thr Leu Gln Val Val Arg His Val Ile Asn 385 390 395 tca gct gct gct cag atg gaa gat aaa aag ccc ttt atc ctg tct tcc 1311 Ser Ala Ala Ala Ala Gln Met Glu Asp Lys Lys Pro Phe Ile Leu Ser Ser 400 405 410 atg agg ctt cct ctc ctg gac acc aac agc aag gtg aag cgg gca gtg 1359 Met Arg Leu Pro Leu Leu Asp Thr Asn Ser Lys Val Lys Arg Ala Val 415 420 425 gtg cag gtg att agc gcc atg gcc cac cac ggc tac ctg gag cag cct 1407 Val Gln Val Ile Ser Ala Met Ala His His Gly Tyr Leu Glu Gln Pro 430 435 440 445 gga ggt gag gcg atg atc gag tac atc gtg cag cag tgc gcg ctg ccc 1455 Gly Gly Glu Ile Glu Tyr Ile Val Gln Gln Cys Ala Leu Pro 450 455 460 ccc gag cag gag cct gag aag cca ggc ccc ggc agc aag gac ccc aag 1503 Pro Glu Gln Glu Pro Glu Lys Pro Gly Pro Gly Ser Lys Asp Pro Lys 465 470 475 475 gcc gac agc gtg cgg gcc atc agc gtg cgc acc ctc tac ctg gtc agc 1551 Ala Asp Ser Val Arg Ala Ile Ser Val Arg Thr Leu Tyr Leu Val Ser 480 485 490 acc acc gtg gac agg atg agt cac gtc ctc tgg cca ctc cag 1599 Thr Thr Val Asp Arg Met Ser His Val Leu Trp Pro Tyr Leu Leu Gln 495 500 505 ttc ctc acc cct gtg cgc ttc act ggg gcc ctg act ccg ctc tgc agg 1647 Phe Leu Thr Pro Val Arg Phe Thr Gly Ala Leu Thr Pro Leu Cys Arg 510 515 520 525 agc ctc gtg cat ctg gcg cag aag agg cag gag gcc ggg gcc gac gcc 1695 Ser Leu Val His Leu Ala Gln Lys Arg Gln Glu Ala Gly Ala Asp Ala 530 535 535 540 ttc ctc atc ag tac gac gcc cat gcg agc ctc ccg tct ccc tat gct 1743 Phe Leu Ile Gln Tyr Asp Ala His Ala Ser Leu Pro Ser Pro Tyr Ala 545 550 555 gta acc gga aga ctg ttg gtt gtg tct tcc agc ccc tac cta ggg Val Thr Gly Arg Leu Leu Val Val Ser Ser Ser Pro Tyr Leu Gly Asp 560 565 570 gga cgt ggg gca gcg gcg ctg cgc ctc ctc agt gtt ctg cac cca aac 1839 Gly Arg Gly Ala Ala Ala Leu Arg Leu Leu Ser Val Leu His Pro Asn 575 580 585 att cac cct ttg ctg ggt cag cat tgg gaa acg act gtc ccg ctg ctg 1887 Ile His Pro Leu Leu Gly Gln His Trp Glu Thr Thr Val Pro Leu Leu 590 595 600 605 ctg ggg tac ctg gat gag cacca gaa gag acc ctg cca cag gag gag 1935 Leu Gly Tyr Leu Asp Glu His Thr Glu Glu Thr Leu Pro Gln Glu Glu 610 615 620 tgg gag gag aag ctg ttg atg ttc ctg cga gac acc ctg gcc atc att 1983 Trp Glu Glu Leu Met Phe Leu Arg Asp Thr Leu Ala Ile Ile 625 630 635 tct gac aac gcg tgg atc tgc cag ctg agc ctg gag ctg tgc agg cag 2031 Ser Asp Asn Ala Trp Ile Cys Gln Leu Ser Leu Glu Leu 640 Arg 5 650 ctg ccc tgc tac gat gag gca ccc cag gag aag aac ttc ctg tac aaa 2079 Leu Pro Cys Tyr Asp Glu Ala Pro Gln Glu Lys Asn Phe Leu Tyr Lys 655 660 665 tgc ata ggc acc acc ctg ggt ggt gct gct tca gag gtg gtg agg 2127 Cys Ile Gly Thr Thr Leu Gly Ala Ala Ser Ser Lys Glu Val Val Arg 670 675 680 685 aag cac ctt caa gag ctg ctg gag acg gcc aga tac cag gag gag gca 2175 Lys His Leu Gln Glu Leu Leu Glu Thr Ala Arg Tyr Gln Glu Glu Ala 690 695 700 gaa cgc gag ggc ctc gcc tgc tgc ttc ggg atc tgt gcc atc tcc cac 2223 Glu Arg Glu Gly Leu Ala Cys Cys Phe Gly Ile Cys Ala Ile Ser His 705 gag 715 g acg ctg gcc cag ctg gag gac ttc gtg agg tca gag gtc 2271 Leu Glu Asp Thr Leu Ala Gln Leu Glu Asp Phe Val Arg Ser Glu Val 720 725 730 ttc aga aaa tcc att ggc att ctc aac att ttt aag gat cga Phe Arg Lys Ser Ile Gly Ile Leu Asn Ile Phe Lys Asp Arg Ser Glu 735 740 745 aac gaa gtg gag aag gtg aag agt gct ctg atc ctg tgc tat ggg cac 2367 Asn Glu Val Glu Lys Val Lys Ser Ala Leu Ileu Tyr Gly His 750 755 760 765 gtg gcg gcc cgg gcc ccc cgg gag ctg gtg ctg gcc aag gta gag tca 2415 Val Ala Ala Arg Ala Pro Arg Glu Leu Val Leu Ala Lys Val Glu Ser 770 775 780 780 gac atc ctc cgg aac atc cag cac ttc agc acc aag gac cca gcc 2463 Asp Ile Leu Arg Asn Ile Cys Gln His Phe Ser Thr Lys Asp Pro Ala 785 790 795 ctg aag ctg tgc ctt gtc cag agt gtg tgc atg gtc agc cgc gcc atc 25c Leu Val Gln Ser Val Cys Met Val Ser Arg Ala Ile 800 805 810 tgc agc agc acc cag gct ggc tcc ttc cac ttc acc cgg aaa gca gag 2559 Cys Ser Ser Thr Gln Ala Gly Ser Phe His Phe Thr Arg Lys Ala Glu 815 820 825 ctg gtg gca cag atg atg gag ttc atc agg gca gag ccc ccg gac tcc 2607 Leu Val Ala Gln Met Met Glu Phe Ile Arg Ala Glu Pro Pro Asp Ser 830 835 840 845 ttg agg aca cct att cgg aag aaa gcc atg tgc act tac ttg 2655 Leu Arg Thr Pro Ile Arg Lys Lys Ala Met Leu Thr Cys Thr Tyr Leu 850 855 860 gtc tcc gtg gag cca gcg ctg gac gag cag gcc cgg gcg gat gtg atc 2703 Val Ser Val Glu Pro Ala Leu Asp Glu Gln Ala Arg Ala Asp Val Ile 865 870 875 cat ggc tgc ctg cac agc atc atg gcc ctg ctg cct gag ccc aag gag 2751 His Gly Cys Leu His Ser Ile Met Ala Leu Leu Pro Glu Pro Lys Glu 880 885 gag gga ggc tgc cag aag tcc ctg tat ctg gag aca ctg cac gcc 2799 Glu Asp Gly Gly Cys Gln Lys Ser Leu Tyr Leu Glu Thr Leu His Ala 895 900 905 ctt gag gat ctg ctg acg agc ctc ctg cag cgg cag cg ag 2847 Leu Glu Asp Leu Leu Thr Ser Leu Leu Gln Arg Asn Met Thr Pro Gln 910 915 920 925 ggc ctg cag atc atg att gag cac ctg agc cca tgg atc aag tcc cca 2895 Gly Leu Gln Ile Met Ile Glu His Leu Ser Trp Ile Lys Ser Pro 930 935 940 aga ggt cac gag cgg gcg cgg gcc ctg ggc ctg agc gcc ctc ctg ctg 2943 Arg Gly His Glu Arg Ala Arg Ala Leu Gly Leu Ser Ala Leu Leu Leu 945 950 955 cgc tg cc gc ct gc cgc tg cc gc ct gc cgc ct gac ct gac cgt gtc agc gcc ctg gtg ccc ttc cac 2991 Arg Tyr Phe Leu Glu His Leu Arg Val Ser Ala Leu Val Pro Phe His 960 965 970 aac ctg ggc ctt ctc atc ggc ctc ttc tcc cca cgg tgt gcg Asac ctg 30 Gly Leu Leu Ile Gly Leu Phe Ser Pro Arg Cys Ala Asp Leu 975 980 985 tgg cct gcc acc cgc cag gag gcc gtg gac tgt gtc tac tcc ctg ctg 3087 Trp Pro Ala Thr Arg Gln Glu Ala Val Asp Cys Val Tyr Ser Leu Leu 990 995 1000 1005 tac ctc cag ctc ggc tat gag ggc ttc tcc cgg gac tac cgc gat gac 3135 Tyr Leu Gln Leu Gly Tyr Glu Gly Phe Ser Arg Asp Tyr Arg Asp Asp 1010 1015 1020 gtg gcg gc cgg ag cc gc ag cc gc ag cc gc ag cc ag ggc ctc gtg cac cct gac 3183 Val Ala Glu Arg Leu Leu Ser Leu Lys Asp Gly Leu Val His Pro Asp 1025 1030 1035 ccc gcc att ctc ttc cac acc tgc cac agt gta ggc cag ctg gtc atg 3231 Pro Ala His Leu Phe Cys His Ser Val Gly Gln Leu Val Met 1040 1045 1050 gtg ctt tgt cta ctg cca tct gaa ggg agg atg acc ctg ggc acc gcg 3279 Val Leu Cys Leu Leu Pro Ser Glu Gly Arg Met Thr Leu Gly Thr Ala 1055 1060 1065 tcc cct ccc cga ccc atg cct gcc tgg tct act ctg agg ctc agc tca 3327 Ser Pro Pro Arg Pro Met Pro Ala Trp Ser Thr Leu Arg Leu Ser Ser 1070 1075 1080 1085 caa cac aag ctt gaa tta ttg cca agc gcc tcc ccc cag acc agc tca 3375 Gln His Lys Leu Glu Leu Leu Pro Ser Ala Ser Pro Gln Thr Ser Ser 1090 1095 1100 tca gcc tct tgc taaccatgtt tgaggccctg ggagaccccg aaaagaactg 3427 Ser Ala Ser Cys 1105 ctcccgcggcgcgcgcgcgcgcgcgcgcgcgcgcggcgcgcgcgcggcggcgcgcgcgcgcgcggcgcgcgcgcgcgcgcgcgcgcgcggcgcgcgcgtc tgagcgtcct gcgctccaag cttcaggagg cccagggaga 3547 gcacgtcctg ccggccgccc agcacagcgt gtacctcctg gccacccagc actgcgcagc 3607 cgtggtgtcc agcctcctgg gcagcccctt gcccttggac aggtacccag ctcagactcc 3667 aggcttaggg gtccctctgg aatgatgctc cccctggaat gatgctcccc gagccctcca 3727 cccggctctg caccccgact ttctgcatga gttcccatgg ctgtaggcca cgtgggacag 3787 aaagtgacat ggagctaggc cccagtctct caggtaccca cggggacctc tcctctccag 3847 gcgttttggg atcctcactg gctccggtgg gccctgcaca gcacccccac agggaagctg 3907 ctgtttctgc cttcctctaa ggtcccaaaa ctgcctggct gctctgttgg ccccaggctc 3967 cagcacacac tggaggctgc ccctcaccct gtgtcttggt tccggctact ccaagccttg 4027 tcctctgcag ggcatccact gctgcctgtg agcagacccc tgggaactgc ctgatccg caaccttgtc tgtaccatac atcactatgt cttcccaagc 4147 tcacacctcc cagctcccag caaagggcag ggcgtgtcta ccacccacca gcccactggg 4207 gtcccccttc ctcgccgagg cctccggagc atgggtctgc tggcccttcc tttctttgcc 4267 atcttagtca tggacagagg ctggcccagg ggcacctggc ttcctgtgac ctccgggaga 4327 ctccatgctg ggcaaggcag agtgaccctt cccctggcag gcgggggcat gaggctgcca 4387 cggggaacac aggtttcctt gcacctggcc ctttaccctg tcagctttgc tgttttcatg 4447 tgctctgacg ccctcccatt aggtgcatcc aagctgcaat gcccacttcc tcctggcagg 4507 ggggacccgc aggcaccttc tgctcagagg tgcacttgtc tggtggccct gctccttcct 4567 ggtactgttg acctttctgt gtgtttgttt taaatctctt gcatggtaaa tagctgcatt 4627 ttgttactga taagagtgag tttaaatcca ctgtcatatc ttttgcgtct ttgttacaca 4687 ttttgttttt taaaaatctt ctttcttgtc cttttttaga ttgacagtgt ccctcttacc 4747 tcactttctc cactcagttt gtaatcctgc agtctgttgc ttttctttta gcgtttgccc 4807 taaaggtggc tgcatgtgtc ctcactgaag tccagcatgg gccccaaatg caggctgagg 4867 tctgggtctg gctgggctgc tgggcgcccg agtcatcatg accattgttc ctgggcacag 4927 ccggcgttga cttgtatttc ctcc gtgatt accgcctggc tcatcaatca ctgttttcgt 4987 tttccgtgga ggcgtggctc acacaaaggg caagcacgga gtcactgggt cctgcaggac 5047 tttccaggtc aaggcagagg aggtgtccgg tccccagcag gctcctgtgt gcccctcagt 5107 cccctagagg gtcacggcca cctgaccgcc accactagag gttttggcga ttgtgctgtg 5167 tggtgggtct tcccggcctc tgcttagcac agcagtgctg ctgcccatcc ttcctccttg 5227 ccaggtagtg ccgggtgctg ctgcccatcc ttcctctgcc gggcagtgcc gggtgctgct 5287 gcccatcctt tctccttgcc gggtagtgcc gggtgctgct gcccatcctt tctccttgcc 5347 ggacagtgct gggtgccgtg tgggctgcac tgtgtgtgtg tttctaggtg atggacattc 5407 agattgtttt ttggtttggg gctgctgggg atggcgatgc tttgaatgtt cctgggagtg 5467 tctgttggtg ggtagagcat gcatttctct ttcgtgtgta tataggagtg gaatcaaggc 5527 cgggcactgt ggctcatacc tgtaatccca gcagtgtggg aggctgaggc aggaggatta 5587 cctgaggtca gaagtttgcg accagcctgg ccaacatggc aaaaccccgt ctctactgaa 5647 aatataaaaa ttggccaggc atggccaggc gcagtggctc acccctgtaa tcccagcact 5707 ttgggaggct gaggtgggtg gatcacgagg tcaggagatc gagaccatcc tggctaacat 5767 ggtaaaaccc cgtctctact aaaaatata a aaaattagcc aggcgaggtg gcaggcgcct 5827 gtagtcccag ctactcggga ggctgaggca ggagaatggt gtgaacccag gaggcggagc 5887 ttgcagtgag ttgagattgc accactgcac tccagcctgg gcgacagagc aagaactct 5951 <210> 25 <211> 5965 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2657) .. (4528) <400> 25 gctgtccggc tcttcctgcc gcgctctggc cactccccct cgcccctcgc tgggcttggc 60 cttggcggcc gtgctctgca ggcagtgcct ccctcgggcg tgggtctgca ggagagccgg 120 acagggcagc ggccggcact accgcgctgc gatttgcgca gagctgaaga agcccctgac 180 cattgaagag gtggcccccg ccccgtcggg cctcacgagg tcagagttga tgtccatttc 240 tgtggagtta actttggtga tattttgatc tgccgtgatc aatatcagga aaggccccat 300 cttcccttca cacctgcctg gcatgggagg gcaggattgt ggtggtggga tttgctggag 360 gaaacattgc ttctgaacca gccaaccttc tgctcctgaa gaatatctct gctatgggcc 420 tgtactgtgg tcaatacaaa gatatgaact ttcccgtctt ctccaagagc ctatcttcag 480 tgcttcagta ctgccagcaa gggtgcatcc agctatatgt cagaatggtt ttcaagctgg 540 acgagataag cagaagacat ctttaggatt cttttgtgtg tttggaacag agagaggaaa 600 aacccagatc catttaagat tcagcagagg gcttggaagc ctaagagttc aggaagataa 660 aataactgca caacttactc aaaacccagg acaaattcag agagtcaagg atggaacttt 720 gggctcccca gaggctgccc cagacacgag ggaaggccac agcaccctca aaggatccag 780 accgagggtt tcggagagat ggacatcatc ggcctgtccc tcactcttgg cacaatggag 840 agaggtttca ccaatggcaa gacaaccgtg ggagccccca gccacagcag gagcccaggg 900 cagaccatca gcagcagccc cattatgcat ccaggccagg ggactggcat cagcctgtgt 960 ctggagttga ctattacgaa ggtggttatc gcaatcagtt gtattcaagg ccaggttatg 1020 agaattcata tcagagctat cagtctccca caatgaggga ggaatatgct tatggaagtt 1080 attactatca tggacaccct cagtggctgc aggaagaaag agtgccaagg caacggagtc 1140 cttatatctg gcacgaagat taccgagagc aaaagtacct tgatgaacat cattatgaaa 1200 accagcacag tccatttgga acaaatagtg agacccactt ccaatctaac agtaggaacc 1260 cttgtaaaga cagccctgct tccaactctg gacaggagtg gccgggggag ctgtttccag 1320 ggagcctgct tgctgaggcc cagaaaaata agccatcatt ggctagtgag tccaaccttc 1380 tccagcagcg tgagtctggt ctcagctcca gcagctatga gctcagtcag tacatcagag 1440 atgccccgga gcgggatgat cccccagctt cagcagcttg gagtccagtt caggctggtg 1500 ggttctaaaa tgatcagaag agttgattga atctgatgtg gaagggctgg gtggcaagtc 1560 tctgggaaag tcagccttat gatggatcat tgtccacctc atttgcttat gtaggtcacc 1620 tgggcagaga ggtcaacttt ggttccattt tctctctttt tgcttgtaat agtaattgca 1680 tcatagctga ttcctgga ag ggaacactgc ccctatccat tatcaagttg ggaaaggagg 1740 cactcagtgg tgcttttaag aaagggaaga ccagagagaa ttaggaaaag caaaagcaag 1800 atgcaaagct tcattgcttt gtctggatgt aggaactttg tcatgagtat agaggccatg 1860 aaagccagag actccttggc ctctcagcat cactgagagt ctgggctgag agcattatca 1920 tttggactga atcatcaagc ccacgcattg tattctgaca ccttctcaga ggcttaaatc 1980 tgactggagc agggaacatg ggcttcttct aattacacaa cccacccaga atcttatttt 2040 ggttcaggca gaatttgggc agaaatacat ctgtggcata ttcctaaact aaagaaaagt 2100 gatggaagta acgctaacaa tgtccatctg tgtctgttgg tcagaagatg tctcctcagc 2160 tggtcccaaa gcacccatga agttctacat ccctcatgtt cctgtgagtt tcgggccagg 2220 aggtcagctg gtgcgtgtag gtcccagctc tcccactgac gggcaagcag cccttgttga 2280 actgcacagc atggaggtaa agaagaccca gtgtccctgg aatgctggca cactgcttac 2340 ccaactactc ctaacatgct taccttgctt tcctgtgcct gagccggggc atctccagga 2400 atgggatgct cttgcgggaa actgggccat gtaccccctg gattaggagg gtgcaggaat 2460 gggtggggct cttctctgaa agaattgatg ctacagttgt gtttttcctg agatgtcaat 2520 gtctcatctt tagcaacaaa at tcactttt ttctttctgc tttctccaca aggccttgag 2580 ccatatccta gccccacggc cttggggtct gacactagac ttgactgaaa ggggcctagg 2640 gtggccacag tcttaa aca caa aat cta att gtt tta ttc cag gtt Att gat Att Gag Att Gag Att Gag Att Gag Att Gag Att Gag Att Gall atg aga agt ttc tca gga ccc ttg 2740 Asn Asp Ser Glu Glu Gln Glu Glu Met Arg Ser Phe Ser Gly Pro Leu 15 20 25 att agg gaa gat gta cat aag gtg gat att atg acg ttt tgc cag cag 2788 Ile Arg Glu Asp Val His Lys Val Asp Ile Met Thr Phe Cys Gln Gln 30 35 40 aaa gca gct cag agc tgc aaa tct gag aca ctg ggg agc aga gac tca 2836 Lys Ala Ala Gln Ser Cys Lys Ser Glu Thr Leu Gly Ser Arg Asp Ser 45 50 55 60 gct cta ctg tgg cag ctc ttg gtt ctc ctt tgt cgc cag aat ggg tcc 2884 Ala Leu Leu Trp Gln Leu Leu Val Leu Leu Cys Arg Gln Asn Gly Ser 65 70 75 atg gtg ggg tct gac atc gct gag ctg cta atg tgc aag aag 2932 Met Val Gly Ser Asp Ile Ala Glu Leu Leu Met Gln Asp Cys Lys Lys 80 85 90 ctg gag aag tac aag cgg cag ccc cct gtg gcc aac ctc atc aac ctg 2980 Leu Glu Lys Tyr Lys Arg Gln Pro Pro Val Ala Asn Leu Ile Asn Leu 95 100 105 acc gat gag gac tgg cca gtg ctg agc tct ggg acc ccg aac ctg ctc 3028 Thr Asp Glu Asp Trp Pro Val Leu Ser Ser Gly Thr Pro Asn Leu Leu 110 115 120 acg gga gag atc ccc ccc agt gtg gag aca cct gcg cag atc gtg gag 3076 Thr Gly Glu Ile Pro Pro Ser Val Glu Thr Pro Ala Gln Ile Val Glu 125 130 135 140 aaa ttc act agg ctg ctc tac tat gga agg aag aag gaa gcc ttg gag 3124 Lys Phe Thr Arg Leu Leu Tyr Tyr Gly Arg Lys Lys Glu Ala Leu Glu 145 150 155 tgg gcc atg aag aac cac ttg tgg ggc cat gct ttgtt gtt 3172 Trp Ala Met Lys Asn His Leu Trp Gly His Ala Leu Phe Leu Ser Ser 160 165 170 aag atg gac cca cag acc tac agc tgg gtc atg agt ggc ttc acc agc 3220 Lys Met Asp Pro Gln Thr Tyr Ser Trp Val Met Ser Gly Phe Thr Ser 175 180 185 acg ctg gcg ctc aat gac cca ctg cag acc ctc ttc cag ctc atg tcg 3268 Thr Leu Ala Leu Asn Asp Pro Leu Gln Thr Leu Phe Gln Leu Met Ser 190 195 200 ggg agg att cca cag gca gcc acg tgt tgt gga gaa aag cag tgg gga 3316 Gly Arg Ile Pro Gln Ala Ala Thr Cys Cys Gly Glu Lys Gln Trp Gly 205 210 215 220 gac tgg agg cct cac ttg gct gtg att ctg tcg aat cag gct ggg gac 3364 Asp Arg Pro His Leu Ala Val Ile Leu Ser Asn Gln Ala Gly Asp 225 230 235 cca gag ctg tat cag cgt gcg att gtt gcc att ggg gac acc ctg gct 3412 Pro Glu Leu Tyr Gln Arg Ala Ile Val Ala Ile Gly Asp Thr Leu Ala 240 245 250 ggg aag ggg ctt gtg gag gca gct cac ttc tgc tat ctc atg gct cac 3460 Gly Lys Gly Leu Val Glu Ala Ala His Phe Cys Tyr Leu Met Ala His 255 260 265 gtg ccc ttt ggc cac tac acc gtg aagca cat ctg gtc ttg ctg 3508 Val Pro Phe Gly His Tyr Thr Val Lys Thr Asp His Leu Val Leu Leu 270 275 280 ggc agc agc cac agt caa gag ttt ttg aaa ttt gca aca act gag gca 3556 Gly Ser Ser His Ser Gln Glu Phe Leu Lys Phe Ala Thr Thr Glu Ala 285 290 295 295 300 atc cag agg acg gaa atc ttc gag tac tgt cag atg ctg ggc cgc ccc 3604 Ile Gln Arg Thr Glu Ile Phe Glu Tyr Cys Gln Met Leu Gly Arg Pro 305 310 315 a aa tcc ttc atc cct tct ttc cag gtg tat aag ctc ctt tat gct tcc 3652 Lys Ser Phe Ile Pro Ser Phe Gln Val Tyr Lys Leu Leu Tyr Ala Ser 320 325 330 cgt ctg gca gat tat ggc ctc gtg tcc cag gctg tgc gaa 3700 Arg Leu Ala Asp Tyr Gly Leu Val Ser Gln Ala Leu His Tyr Cys Glu 335 340 345 gcc att ggt gca gct gtc ttg agc cag gga gag agc agt cac cct gtg 3748 Ala Ile Gly Ala Ala Val Leulu Gln Ser Ser His Pro Val 350 355 360 cta tta gtg gaa ctc atc aag cta gca gag aaa ctg aag ctg tca gat 3796 Leu Leu Val Glu Leu Ile Lys Leu Ala Glu Lys Leu Lys Leu Ser Asp 365 370 375 380 380 cct ctg gtt tta gaa aga cgc agt gga gac agg gac ctg gag cca gat 3844 Pro Leu Val Leu Glu Arg Arg Ser Gly Asp Arg Asp Leu Glu Pro Asp 385 390 395 tgg cta gcg caa ctt cgg agg cag ctg gag caa aag gta gca Gga gac 3892 Ala Gln Leu Arg Arg Gln Leu Glu Gln Lys Val Ala Gly Asp 400 405 410 att ggg gat cct cat cct act cgc tca gat att tcg gga gcc gga gga 3940 Ile Gly Asp Pro His Pro Thr Arg Ser Asp Ile Ser Gly Ala Gl y Gly 415 420 425 aca aca aca gaa aac act ttc tac cag gac ttt tct gga tgt caa ggc 3988 Thr Thr Thr Glu Asn Thr Phe Tyr Gln Asp Phe Ser Gly Cys Gln Gly 430 435 440 440 tac tct gaa gcc cct ggg tac cgc tca gct ctg tgg ctg aca cct gag 4036 Tyr Ser Glu Ala Pro Gly Tyr Arg Ser Ala Leu Trp Leu Thr Pro Glu 445 450 455 460 cag acc tgc ctg ctc cag ccc agc cca cag cag ccc ttt ccc ctc cag 4084 Gln Thr Cysu Gln Pro Ser Pro Gln Gln Pro Phe Pro Leu Gln 465 470 475 ccg ggc tcc tac cca gca gga ggg ggt gca ggg cag aca ggg aca ccg 4132 Pro Gly Ser Tyr Pro Ala Gly Gly Gly Ala Gly Gln Thr Gly Thr Pro 480 485 490 490 agg cct ttt tac tca gtt cct gag acc cat cta cca ggg act ggc agc 4180 Arg Pro Phe Tyr Ser Val Pro Glu Thr His Leu Pro Gly Thr Gly Ser 495 500 505 agc gtg gca gtg aca gag gcc act gga gga aca gtc tgg gag gaa atg 4228 Ser Val Ala Val Thr Glu Ala Thr Gly Gly Thr Val Trp Glu Glu Met 510 515 520 ctg cag aca cac ctg ggc cct gga gag aac aca gtg tct caa gaa act 4276 Leu Gln Thr His Leu Gly Pro Gly Glu Asn Thr Val Ser Gln Glu Thr 525 530 535 540 tcc cag cct cct gat ggc caa gag gtc att tcc aaa cca cag aca cca 4324 Ser Gln Pro Pro Asp Gly Gln Glu Val Ile Ser Lys Pro Gln Thr Pro 545 550 555 ttg gct gct aga gca cga agt att tct gag agt tcc gcc agt tca gcc 4372 Leu Ala Ala Arg Ala Arg Ser Ile Ser Glu Ser Ser Ala Ser Ser Ala 560 565 570 aag gag gat gag aag gag tcc tct gat gag gct gat aaa aac tct ccc 4420 Lys Glu Asp Glu Lys Glu Ser Ser Asp Glu Ala Asp Lys Asn Ser Pro 575 580 585 cga aat act gcc cag aga gag ctc agg gtt tgg ctg gtt cag ctg gtt 4468 Arg Asn Thral Ala Gln Arg Glu Leu Arg Val Trp Leu Val Gln Leu Val 590 595 600 tcg atc gaa gcc cac caa gaa cgc atc ccc cgc tgg aga cga gga ctc 4516 Ser Ile Glu Ala His Gln Glu Arg Ile Pro Arg Trp Arg Arg Gly Leu 605 610 615 620 ctc aga cag ccc tgccagcc gccccgccccg Leu Arg Gln Pro gctggcctgg gcctctcact gacaccttcc cctgagtccc cacctctgcc ggatgttagt 4628 gccttctcca ggggcagagg tgggggtgaa ggccgaggat ccgcatccag cgggggagca 4688 gctgcg ggcg ctggggttgg aggcttgtct ggaccagaga gtgtttcctt tgagctctgc 4748 tccaaccctg gtgttcttct tcctccacct gccttaaaag gggctgttcc tctttacaac 4808 ccatctcagg tgcctcagct gcccacggcc actagcctga atcggccaaa tcgcctagct 4868 cagcgtcgct atcccaccca gccatgctga gaataaacac acgtcccagg ctcatctccc 4928 aggactgaaa ctttcttgct ctctttttct caatctccca gcccctctct accatattgg 4988 gaccctcaag aggtttgtgc tagcccgatg cctccaccgg gcacttagaa ggcaagagga 5048 caggatctct caagacacag cacaattcag tctcttaaga ttaacttcac aatgatggaa 5108 attatttcat caggtggaaa gtctgggtct aatagcagac tgcacatgag cagagtgaca 5168 tggtggtggc acttatggtg gtggcttgag agccttgggg aaattagggc cctaacagct 5228 agaatcaaag atgataccgc agggccctgt agcaagaaat gggaagcagg gggaggggca 5288 ggggctcaga acaatattct agaccaactt tgactacttc ctgtcttagt aatagaccaa 5348 tacatggctc tatttagcaa agtttttata ctgaaacttg attattgctg ccctttataa 5408 tttcctcttc aatgatattt cagcagtttc cctcttggtc ctagttttgt gcacattttt 5468 ttgaatgtgg ttcagattaa ttatatttct ctcactttct tagctggtcc tattttttca 5528 cattctggca tgtggctatc aagttagatt gctgtaggca tcatattgtc atggtaacta 5588 ctgaacctaa tgatgcagat ggatggcaca tcagtataat aaatgatgga aaacggttcc 5648 taaaaattca tccctttcat aagaggggaa gaatgagtgc ctgatattgt taatacctcc 5708 ctttctacct caggcctttg caaattgatg ttcagagggt cactggagtg agagggagga 5768 ggggggcgtc ttggaaattt ccatttctct tttcaaaccc aaaataggaa tgactcttgc 5828 tgtttgtcag atttgctgaa aattgctcct cacaaagaac attttttttt gtacatgtaa 5888 ttgtaaatac aggtttagta cgttaatatt ctatagttct gatgttgata ataattaaac 5948 ccagataatt ttatagc 5965 <210> 26 <211> 6481 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3934) <400> 26 g gag gca gcc cgg cgc cgc cag cag cgc gag agc aag agc aac gcg gcc 49 Glu Ala Ala Arg Arg Arg Gln Gln Arg Glu Ser Lys Ser Asn Ala Ala 1 5 10 15 acg ccc act aag ggc cca gag ggc aag gtg gcc ggc ccc gcc gac gcc 97 Thr Pro Thr Lys Gly Pro Glu Gly Lys Val Ala Gly Pro Ala Asp Ala 20 25 30 ccc atg gac tct ggt gct gag gaa gag aag gcg gga gca gcc acc gtg 145 Pro Met Asp Ser Gly Ala Glu Glu Glu Lys Ala Gly Ala Ala Thr Val 35 40 45 aag aag ccg tct ccc tcc aaa gcc cgc aag aag aag cta aac aag aag aag 193 Lys Lys Pro Ser Pro Ser Lys Ala Arg Lys Lys Lys Leu Asn Lys Lys 50 55 60 ggg agg aag atg gct ggc cgc aag cgc ggg cgc ccc aag aag atg aac 241 Gly Arg Lys Met Ala Gly Arg Lys Arg Gly Arg Pro Lys Lys Met Asn 65 70 75 80 act gcg aac ccc gag cgg aag ccc aag aag aac ca act gca ctg gat 289 Thr Ala Asn Pro Glu Arg Lys Pro Lys Lys Asn Gln Thr Ala Leu Asp 85 90 95 gcc ctg cac gct cag acc gtg tct cag acg gcg gcc tcc tca ccc cag 337 Ala Leu His Ala Gln Thr Val Ser Gln Thr Ala Ala Ser Ser Pro Gln 100 105 110 gat gcc tac aga tcc cct cac agc ccg ttc tac cag cta cct ccg agc 385 Asp Ala Tyr Arg Ser Pro His Ser Pro Phe Tyr Gln Leu Pro Pro Ser 115 120 125 gtg cag cgg cac tcc ccc aac ccg ctg ctg gggg acc ccg ccc 433 Val Gln Arg His Ser Pro Asn Pro Leu Leu Val Ala Pro Thr Pro Pro 130 135 140 gcg ctg cag aag ctt cta gag tcc ttc aag atc cag tac ctg cag ttc 481 Ala Leu Gln Lys Leu Leu Glu Ser Phe Lys Ile Gln Tyr Leu Gln Phe 145 150 155 160 ctg gca tac aca aag acc ccc cag tac aag gcc agc ctg cag gag ctg 529 Leu Ala Tyr Thr Lys Thr Pro Gln Tyr Lys Ala Ser Leu Gln Glu Leu 165 170 175 ctg ggc cag aag gag aag aac gcc cag ctc ctg ggt gcg gct cag 577 Leu Gly Gln Glu Lys Glu Lys Asn Ala Gln Leu Leu Gly Ala Ala Gln 180 185 190 cag ctc ctc agc cac tgc cag gcc cag aag gag gag atg agg agg agg agg agg ag ag ag ag Leu Leu Ser His Cys Gln Ala Gln Lys Glu Glu Ile Arg Arg Leu 195 200 205 ttt cag caa aaa ttg gat gag ctg ggt gtg aag gcg ctg acc tac aac 673 Phe Gln Gln Lys Leu Asp Glu Leu Gly Val Lys Ala Leu ThryrAsn 210 215 220 gac ctg att caa gcg cag aag gag atc tcc gcc cat aac cag cag ctg 721 Asp Leu Ile Gln Ala Gln Lys Glu Ile Ser Ala His Asn Gln Gln Leu 225 230 235 240 cgg gag cag tcg gag cag ctg gag cag gac aac cgc gcg ctc cgc ggc 769 Arg Glu Gln Ser Glu Gln Leu Glu Gln Asp Asn Arg Ala Leu Arg Gly 245 250 255 cag agc ttg cag ctg ctc aag gct cgc tgc gag gag ctg cag ctg Lec Glec 817 Lys Ala Arg Cys Glu Glu Leu Gln Leu Asp 260 265 270 tgg gcc acg ctg tcg ctg gag aag ctg ttg aag gag aag cag gcc ctg 865 Trp Ala Thr Leu Ser Leu Glu Lys Leu Leu Lys Glu Lys Gln Ala Leu 275 agc cag atc tcg gag aag cag agg cac tgc ctg gag ctg cag atc 913 Lys Ser Gln Ile Ser Glu Lys Gln Arg His Cys Leu Glu Leu Gln Ile 290 295 300 agc att gtg gag cta gag aag agc cag cgg cag cag cag 961 Ser Ile Val Glu Leu Glu Lys Ser Gln Arg Gln Gln Glu Leu Leu Gln 305 310 315 320 ctc aag tcc tgt gtg ccg cct gac gac gcc ctg tcc ctg cac ctg cgt 1009 Leu Lys Ser Cys Val Pro Pro Asp Asp Ala Le u Ser Leu His Leu Arg 325 330 335 ggg aag ggc gcc ctg ggc cgc gag ctg gag cct gac gcc agc cgg ctg 1057 Gly Lys Gly Ala Lela Gly Arg Glu Leu Glu Pro Asp Ala Ser Arg Leu 340 345 350 cac ctg gag tgc acc aag ttc tcg ctg cct cac ttg agc agc 1105 His Leu Glu Leu Asp Cys Thr Lys Phe Ser Leu Pro His Leu Ser Ser 355 360 365 atg agc ccg gag ctc tcc atg aac ggc cag gct gct ggc tat gag ctc Pro Glu Leu Ser Met Asn Gly Gln Ala Ala Gly Tyr Glu Leu 370 375 380 tgc ggt gtg ctg agc cgg cct tcg tcg aag cag aac acg ccc cag tac 1201 Cys Gly Val Leu Ser Arg Pro Ser Ser Lys Gln Asn Thr Pro Gln Tyr 385 390 395 400 ctg gcc tca ccc ctg gac cag gag gtg gtg ccc tgt acc cct agc cac 1249 Leu Ala Ser Pro Leu Asp Gln Glu Val Val Pro Cys Thr Pro Ser His 405 410 415 gtc ggc cgg ccg cgc ctg gag aag ctg ggc cta gcc gca ccc gac 1297 Val Gly Arg Pro Arg Leu Glu Lys Leu Ser Gly Leu Ala Ala Pro Asp 420 425 430 tac act agg ctg tcc ccg gcc aag att gtg ctg agg cgg cac ctg agc 1345 Tyr Thr Arg Leu Ser Pro Ala Lys Ile Val Leu Arg Arg His Leu Ser 435 440 445 cag gac cac acg gtg ccc ggc agg ccg gct gcc agt gag ctg cat tcg 1393 Gln Asp His Thr Val Pro Gly Arg Pro Ala Ala Ser Glu Leu His Ser 450 455 460 aga gct gag cac acc aag gag aac ggc ctt ccc tac cag agc ccc agc 1441 Arg Ala Glu His Thr Lys Glu Asn Gly Leu Pro Tyr Gln Ser Pro Ser 465 470 475 475 480 gtg cct ggc agc atg aag ctg agc cct cag gaccc ctg tcc 1489 Val Pro Gly Ser Met Lys Leu Ser Pro Gln Asp Pro Arg Pro Leu Ser 485 490 495 cct ggg gcc ttg cag ctt gct gga gag aag agc agt gag aag ggc ctg 1537 Pro Gly Ala Leu Gln Leu Ala Gly Glu Lys Ser Ser Glu Lys Gly Leu 500 505 510 aga gag cgc gcc tac ggc agc agc ggg gag ctc atc acc agc ctg ccc 1585 Arg Glu Arg Ala Tyr Gly Ser Ser Gly Glu Leu Ile Thrl Ser Leu Pro 515 520 525 atc agc atc ccg acc gtg cag ccc aac aag ctc ccg gtc agc 1633 Ile Ser Ile Pro Leu Ser Thr Val Gln Pro Asn Lys Leu Pro Val Ser 530 535 540 att ccc ctg gcc agc gtg gtg ctg ccc agc cgc gcc gag agg gcg agg 1681 Pro Leu Ala Ser Val Val Leu Pro Ser Arg Ala Glu Arg Ala Arg 545 550 555 560 agc acc ccc agt ccc gtg ctg cag ccc cgt gac ccc tcg tcc aca ctt 1729 Ser Thr Pro Ser Pro Val Leu Gln Pro Arg Asp Pro Ser Ser Thr Leu 565 570 575 gaa aag cag att ggt gct aat gcc cac ggt gct ggg agc aga agc ctt 1777 Glu Lys Gln Ile Gly Ala Asn Ala His Gly Ala Gly Ser Arg Ser Leu 580 585 590 gcc ctg gcc ccc gca ggcttc gct ggc tcg gtg gcc atc agc 1825 Ala Leu Ala Pro Ala Gly Phe Ser Tyr Ala Gly Ser Val Ala Ile Ser 595 600 605 ggg gcc gtt ttg gcg ggc agc ccg gcc tct ctc aca cct gga gcc gag ccg 1873 Gly Ala Aly Pro Ala Ser Leu Thr Pro Gly Ala Glu Pro 610 615 620 gcc acc ttg gat gag tcc tcc agc tct ggg agc ctt ttt gcc acc gtg 1921 Ala Thr Leu Asp Glu Ser Ser Ser Ser Gly Ser Leu Phe Ala Thr Val 625 630 635 640 ggg tcc cgc agc tcc acg cca cag cac ccc ctg ctg ctg gca cag ccc 1969 Gly Ser Arg Ser Ser Thr Pro Gln His Pro Leu Leu Leu Ala Gln Pro 645 650 655 cgg aac tcg ctt cct gcc tct ccc gcc cac cag ctc t cc tcc agt ccc 2017 Arg Asn Ser Leu Pro Ala Ser Pro Ala His Gln Leu Ser Ser Ser Pro 660 665 670 cgg ctt ggt ggg gcc gcc cag ggc ccg ttg ccc gag gcc agc aag gga 2065 Arg Leu Gly Gly Ala Ala Gln Gly Pro Leu Pro Glu Ala Ser Lys Gly 675 680 685 gac ctg ccc tcc gat tcc ggc ttc tca gat cct gag agt gaa gcc aag 2113 Asp Leu Pro Ser Asp Ser Gly Phe Ser Asp Pro Glu Ser Glu Ala Lys 690 695 700 agg agg att gtg ttc acc atc acc act ggt gcg ggc agt gcc aag cag 2161 Arg Arg Ile Val Phe Thr Ile Thr Thr Gly Ala Gly Ser Ala Lys Gln 705 710 715 720 tcg ccc tcc agc aag cac agc ccc ctg acc gcc agc gcc cgt ggg gac 2 Ser Pro Ser Ser Lys His Ser Pro Leu Thr Ala Ser Ala Arg Gly Asp 725 730 735 tgt gtg ccg agc cac ggg cag gac agt cgc agg cgc ggc cgg cgg aag 2257 Cys Val Pro Ser His Gly Gln Asp Ser Arg Arg Arg Gly Arg Arg Lys 740 745 750 cga gca tct gcg ggg acg ccc agc ttg agc gca ggc gtg tcc ccc aag 2305 Arg Ala Ser Ala Gly Thr Pro Ser Leu Ser Ala Gly Val Ser Pro Lys 755 760 765 cgc cga gcc ctg ccg tcc gc ct ggc ctt ttc aca cag cct tcg ggg 2353 Arg Arg Ala Leu Pro Ser Val Ala Gly Leu Phe Thr Gln Pro Ser Gly 770 775 780 tct ccc ctc aac ctc aac tcc atg gtc agt aac atc aac cag ccc ctg 2401 Ser Prou Leu Asn Ser Met Val Ser Asn Ile Asn Gln Pro Leu 785 790 795 800 gag att aca gcc atc tcg tcc ccg gag acc tcc ctg aag agc tcc cct 2449 Glu Ile Thr Ala Ile Ser Ser Pro Glu Thr Ser Leu Lys Ser Ser Pro 805 810 815 gtg ccc tac cag gac cac gac cag ccc ccc gtg ctc aag aag gag cgg 2497 Val Pro Tyr Gln Asp His Asp Gln Pro Pro Val Leu Lys Lys Glu Arg 820 825 830 cct ctg agc cag acc aat ggg gca cac tac tcc cca ctc acc tca gac 2545 Pro Leu Ser Gln Thr Asn Gly Ala His Tyr Ser Pro Leu Thr Ser Asp 835 840 845 gag gag cca ggc tct gag gac gag ccc agc agt gct cga att gag aga 2593 Glu Glu Pro Gly Ser Glu Asp Glu Pro Ser Ser Ala Arg Ile Glu Arg 850 855 860 aaa att gca aca atc tcc tta gaa agc aaa tct ccc ccg aaa acc ttg 2641 Lys Ile Ala Thr Ile Ser Leu Glu Ser Lys Ser Pro Pro Lys Thr Leu 865 870 875 880 880 gaa aa t ggt ggt ggc ttg gcg gga agg aag ccc gcg ccc gcc ggc gag 2689 Glu Asn Gly Gly Gly Leu Ala Gly Arg Lys Pro Ala Pro Ala Gly Glu 885 890 895 cca gtc aat agc agc aag tgg aag tcc c ccc ttc acctc ccc gac 2737 Pro Val Asn Ser Ser Lys Trp Lys Ser Thr Phe Ser Pro Ile Ser Asp 900 905 910 atc ggc ctg gcc aag tcg gcg gac agc ccg ctg cag gcc agc tcc gcc 2785 Ile Gly Leu Ala Lys Ser Ala Asp Ser Pro Leu Gln Ala Ser Ser Ala 915 920 925 ctc agc cag aac tcc ctg ttc acg ttc cgg ccc gcc ctg gag gag ccc 2833 Leu Ser Gln Asn Ser Leu Phe Thr Phe Arg Pro Ala Leu Glu Glu Pro 930 935 940 940 tct gcc gat gcc aagct gct cac ccc agg aaa ggc ttt ccc ggc 2881 Ser Ala Asp Ala Lys Leu Ala Ala His Pro Arg Lys Gly Phe Pro Gly 945 950 955 960 tcc ctg tcg ggg gct gac gga ctc agc ccg ggc acc aac cct gcc aac 2929 Gly Ala Asp Gly Leu Ser Pro Gly Thr Asn Pro Ala Asn 965 970 975 ggc tgc acc ttc ggc ggg ggc ctg gcc gcg gac ctg agt tta cac agc 2977 Gly Cys Thr Phe Gly Gly Gly Leu Ala Ala Asp Leu Ser Le His His r 980 985 990 ttc agt gat ggt gct tct ctt ccc cac aag ggc ccc gag gcg gcc ggc 3025 Phe Ser Asp Gly Ala Ser Leu Pro His Lys Gly Pro Glu Ala Ala Gly 995 1000 1005 ctg agc tcc ccg ctg tgt ccc cgc ggc aag gag ggc tcg 3073 Leu Ser Ser Pro Leu Ser Phe Pro Ser Gln Arg Gly Lys Glu Gly Ser 1010 1015 1020 gac gcc aac cct ttc ctg agc aag agg cag ctg gac ggc ctg gct ggg 3121 Asp Ala Asn Pro Lys Arg Gln Leu Asp Gly Leu Ala Gly 1025 1030 1035 1040 ctg aag ggc gag ggc agc cgc agc aag gag gca ggg gag ggc ggc cta 3169 Leu Lys Gly Glu Gly Ser Arg Ser Lys Glu Ala Gly Glu Gly 10 Glu Gly 10 ctg tgc ggg ccc acg gac aag acc cca ctg ctg agc ggc aag gcc 3217 Pro Leu Cys Gly Pro Thr Asp Lys Thr Pro Leu Leu Ser Gly Lys Ala 1060 1065 1070 gcc aag gcc cgg gac cgc gag gtc gac ctc aag aat gg ctc 3265 Ala Lys Ala Arg Asp Arg Glu Val Asp Leu Lys Asn Gly His Asn Leu 1075 1080 1085 ttc atc tct gcg gcg gcc gtg cct ccc gga agc ctc ctc agc ggc ccc 3313 Phe Ile Ser Ala Ala Ala Val Pro Pro Gly Ser Leu Leu Ser Gly Pro 1090 1095 1100 ggc ctg gcc ccg gcg gcg tcc tcc gca ggc ggc gcg gcg tcc tcc gcc 3361 Gly Leu Ala Pro Ala Ala Ser Ser Ala Gly Gly Ala Ala Ser Ser Ala 1105 1110 1115 1120 cag acg cac cgg tcc ttc ctg ggc ccc ttc ccg ccg gga ccg cag ttc 3409 Gln Thr His Arg Ser Phe Leu Gly Pro Phe Pro Pro Gly Pro Gln Phe 1125 1130 1135 gcg ctc ggc ccc atg tcc ctg cag gcc acc gcc ggc 3457 Ala Leu Gly Pro Met Ser Leu Gln Ala Asn Leu Gly Ser Val Ala Gly 1140 1145 1150 tcc tcc gtg ctg cag tcg ctg ttc agc tct gtg ccg gcc gcc gca ggc 3505 Ser Ser Val Leu Gln Ser Leu Phe Ser Pro Ala Ala Ala Gly 1155 1160 1165 ctg gtg cac gtg tcg tcc gct gcc acc aga ctg acc aac tcg cac gcc 3553 Leu Val His Val Ser Ser Ala Ala Thr Arg Leu Thr Asn Ser His Ala 1170 1175 1180 atg ggc agc ttt tcc ggg gtg gca ggc ggc aca gtt gga ggt agg cag 3601 Met Gly Ser Phe Ser Gly Val Ala Gly Gly Thr Val Gly Gly Arg Gln 1185 1190 1195 1200 ggc ggc cgt ccg tcc gcc ccc cgc ccc ggc ccc cgc cgg agg ccc ctt 3649 Gly Gly Arg Pro Ser Ala Pro Arg Pro Gly Pro Arg Arg Arg Pro Leu 1205 1210 1215 cct ttg cag gtt ccc ttc cgc act ctc ttg cag cag gag ctg agc tgc 3697 Pro Leu Gln Val Pro Phe Arg Thru Leu Gln Gln Glu Leu Ser Cys 1220 1225 1230 agg tcc cct ggt gcc ggc cgg ccc ccg cca tcc gtg cac ggt ggc gaa 3745 Arg Ser Pro Gly Ala Gly Arg Pro Pro Pro Ser Val His Gly Gly Glu 1235 1240 1245 ctc cag tcc tgt ggg gag agg gct cac gct gag tcc gtg tgt ctt ggg 3793 Leu Gln Ser Cys Gly Glu Arg Ala His Ala Glu Ser Val Cys Leu Gly 1250 1255 1260 ttc tct ggt tgt aac cgc gtc cct ctt gtt ttc aga agg cca ccg tg Ser Gly Cys Asn Arg Val Pro Leu Val Phe Arg Arg Pro Pro Cys 1265 1270 1275 1280 gca ggg cca cca gag cat tac ttt ctc ccg tgg agg tca cct gct agg 3889 Ala Gly Pro Pro Glu His Tyr Phe Leu Pro Trp Arg Ser Pro Ala Arg 1285 1290 1295 tgt ggc cgc ccg ggc tct ggc aag gct ctg gga gct ggt gtt ggg 3934 Cys Gly Arg Pro Gly Ser Gly Lys Ala Leu Gly Ala Gly Val Gly 1300 1305 1310 taagagcgag tc cccgcagt gcctgcccag acagggcgga gaggagccgc cggggggagc 3994 ggcctggccc tggggctgct gcggggcggg gggccggagg gcggagggcg ggccaccacg 4054 agcctggccg agccgctgct tgtgcttggt gccagcacac gcctggcggc gccgtttcgc 4114 ttcccttttt gtgagcctgc ggctgctgct ctgcgcttgc ctggatgctg ccgcttgttg 4174 aagctgcgtt tttctctcct atttgcaggt gtctttaacc acgcggtgcc ctccgcctct 4234 gctcatccgt ttggagcccg tgtcggccgc ggggctgcat gtggcagcgc cacactgggc 4294 ccgagcccgc tgcaggcggc ggccagcgcc tcggcctctt cctttcaggc cccggcctcg 4354 gttgagaccc ggccgccccc tccgcctccg cctccgcctc ccccgctgcc cccgcctgcg 4414 cacctgggcc ggtcccccgc ggggccgccc gtcctccacg ccccccctcc acctaacgcc 4474 gccttgcctc ctcccccaac gctgctggcc tctaaccctg agcccgcgct tctgcagagc 4534 ctcgcgtccc tcccgcctaa ccaagctttc ttgcccccca cctctgctgc ctctctgccg 4594 cctgctaacg cctctttgtc tatcaagctc acctccctcc cgcacaaggg cgcccgcccc 4654 tccttcacgg tgcaccacca gcccctgccc cggctggccc tggcccaggc cgcgcccggg 4714 atcccacagg ccagcgccac ggggccgtcc gcggtgtggg tgtccctcgg catgccgcct 4774 ccctatgccg cgcacctt tc gggggttaag ccgcgataaa gaccttgctt agctagcagt 4834 gcgtattgtg taaggtaagg ccagagccct gcgcggtggc tcactccaga cactgaactg 4894 tccttccttt ggcagagaag acggccacag ggctcggcag aagttccggg ggtcctgagg 4954 agggaagagg gagagagcca gggagaccag ggagatggtc gcgagaggag ggactacagg 5014 acgggcacca gccatggagt ggcctgagtg tgttgggttc cagctgcccg cagctgggtt 5074 cctgcggtga cgccgcagga ctgaggccag ccctgggggc agctgtgcca gcccctgtgg 5134 gcgaggctca cggggtgcca ggccaggggg ctgggagctc tagctcctag agcagtctcc 5194 agggctccat ccgcaccagg cccaggtcac tcatgacggg tggcgtggct tggtgctgtt 5254 ccccaggcgc ccagcatgta gcaggcacgg tgccggctgc agaggtcctg gagagccagg 5314 gtggctggct ggatgcctct ggtcggggct gtctggccag tagcctcgga tgccctcata 5374 gggagccagt gaagccccaa gtgccctgcc tgcctggggg ctgatgggtt cccggcgggg 5434 tcgagaggca agctctgtgc cctgcgtgtt gaggccccct tgctggacac ggctgatggc 5494 cacactgccc tgtggtcatg gcccacagcc gaggggcttt cagctgctca gatgtcagca 5554 ccaagctggg caggttagtg tagacggtgc ccacctttga gaccagaagg aagttggaag 5614 caggagtgat tttgatgatg tg aggccttc agggaatgtc ctgttcactc ctcccccaag 5674 aggctgtgga gactgtggcc gctgacccct gagggcagtt ggccacccgt gccctccagg 5734 gacatggcgt gcctggcggc gtagtgcaaa ggtgccctct gcttgcccct ggccttctgc 5794 ctcaggggcc cctgggacac aggccttcct gggcgagtcc aaagcccacc gggcaaggag 5854 aggaggactg ggagccagga gccaaggcgg aggctgtggc cagggctggt cagcctggcg 5914 ggtcaatgcg ggcacctgcg ggctggacaa gctatgctgg gtctcttagg agatgagctg 5974 caggtagggt ggctttagct ggactcggct gtgtgtctcc tttggaggaa ggctggagct 6034 tggccggcgt gtccaggtgt caggctccct ggtctgtcac ggggcacgcc cgtcgtctgt 6094 tgtggttaga ggagctggca ctatgcctgt catggtgctg gccccaggtg gcgtgtgtgc 6154 tcgtgggagg cctcggtccc cagcctgggt gagtgttggg ctcccccagg cgcgatggta 6214 acctcaggcc gctcttcccg ctgtgccctt ctgcaggtaa ctaggatttc tacctcaacc 6274 gcgagaccta tgcaaggacg gtgtggacca actcgcgccc gcggcatggt gcccgccggc 6334 ctgccgggct cccacccctg gacggcagag gcaaggacgg acgggagctc cactgtgaat 6394 cggcggcacg cgccgcagga ggctgggact ggtccagttt gtactgtcga tagttttaga 6454 taaagtattt atcatttttt aaaaagt 6481 <210> 27 <211> 5956 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (746) <400> 27 cc gac atc ggt tgg att aca gga cac agc tac gtg gtg tat ggg cct 47 Asp Ile Gly Trp Ile Thr Gly His Ser Tyr Val Val Tyr Gly Pro 1 5 10 15 ctc tgc aat ggt gcc acc agc gtc ctt ttt gag agc acc cca gtt tat 95 Leu Cys Asn Gly Ala Thr Ser Val Leu Phe Glu Ser Thr Pro Val Tyr 20 25 30 ccc aat gct ggt cgg tac tgg gag aca gta gag agg ttg aag atc aat 143 Pro Asn Ala Gly Arg Tyr Trp Glu Thr Val Glu Arg Leu Lys Ile Asn 35 40 45 cag ttc tat ggc gcc cca acg gct gtc cgg ctg ttg ctg aaa tac ggt 191 Gln Phe Tyr Gly Ala Pro Thr Ala Val Arg Leu Leu Leu Lys Tyr Gly 50 55 60 gat gcc tgg gtg aag aag tat gat cgc tcc tcc ctg cgg acc ctg ggg 239 Asp Ala Trp Val Lys Lys Tyr Asp Arg Ser Ser Leu Arg Thr Leu Gly 65 70 75 tca gtg gga gag ccc atc aac tgt gag gcc tgg gag tgg ctt cac agg 287 Ser Val Gly Glu Pro Ile Asn Cys Glu Ala Trp Glu Trp Leu His Arg 80 85 90 95 gtg gtg ggg gac agc agg tgc acg ctg gtg gac acc tgg tgg cag aca 335 Val Val Gly Asp Ser Arg Cys Thr Leu Val Asp Thr Trp Trp Gln Thr 100 105 110 gaa aca ggt ggc atc tgc atc gca cca cgg ccc tcg gaa gaa ggg gcg 383 Glu Thr Gly Gly Ile Cys Ile Ala Pro Arg Pro Ser Glu Glu Glu Gly Ala 115 120 125 gaa atc ctc cct gcc atg gcg atg agg ccc ttc ttt ccc 431 Glu Ile Leu Pro Ala Met Ala Met Arg Pro Phe Phe Gly Ile Val Pro 130 135 140 gtc ctc atg gat gag aag ggc agc gtc gtg gag ggc agc aac gtc tcc 479 Val Leu Met Asp Glu Lys Gly Ser Val Glu Gly Ser Asn Val Ser 145 150 155 ggg gcc ctg tgc atc tcc cag gcc tgg ccg ggc atg gcc agg acc atc 527 Gly Ala Leu Cys Ile Ser Gln Ala Trp Pro Gly Met Ala Arg Thr Ile 160 165 170 175 tat ggc gac cac cag cga ttt gtg gac gcc tac ttc aag gcc tac cca 575 Tyr Gly Asp His Gln Arg Phe Val Asp Ala Tyr Phe Lys Ala Tyr Pro 180 185 190 ggc tat tac ttc act gga gac ggg gct tac cga act gag ggc ggc tat Tyr Tyr Phe Thr Gly Asp Gly Ala Tyr Arg Thr Glu Gly Gly Tyr 195 200 205 tac cag atc aca ggg cgg atg gat gat gtc atc aac atc agt ggc cac 671 Tyr Gln Ile Thr Gly Arg Met Asp Asp Val Ile Asn Ile Ser Gly His 210 215 220 cgg ctg ggg acc gca gag att gag gac gcc atc gtg agc aca ggc tgg 719 Arg Leu Gly Thr Ala Glu Ile Glu Asp Ala Ile Val Ser Thr Gly Trp 225 230 235 gcc tcc tcc ttc act cct aca cct cca tgatgcct Ala Ser Ser Phe Thr Pro Thr Pro Pro 240 245 aagttggggt gggagtccct ggcccgagtc acttctagca cccggggccg ccacattttg 826 cccttttgtt ctctgttgta cacaggccga ccaccctgca gtaccagaaa gtgctgtcat 886 tggctacccc cacgacatca aaggagaagg tgagtgtcct ggagatgagc tcctccctga 946 ttcctgaccc cacacccatt atgggcacct ctgtacgagg agcagactct ggagagtgga 1006 gtgatagggg atactgtggg ccaagctctc agtgttcttc tctctcaagt ggaaactgta 1066 ggggaggagg ctgaatagca ctcgtgttcg gtcgggtttc tgaaatgccc tggttctgct 1126 gtcctttcag gacacacatc cacagtggcc atgacccagt tgggcttggc taagcttggg 1186 gggtttcccc ttctgtccat ggtgtatctg gtggggacac cgtccagccc cattacagag 1246 agtttatgag aaaatgtcca gcctcatgta tcctcacggg cttggtcata gcactcaagc 1306 cagctctgca gccgccacgc gtgtgtgcca gagtgtgctc tggagtgtgc aggctgtgtg 1366 ctgcgctggg actctttgga cgaatctgac c tgtggttcc cactgcacag cgacatgctg 1426 ggggaatgca gaatgaggga ctagaatggc ctttaccaag gccacgcttt gtttcgagtc 1486 tgccagcttc ttggtggctg ggtctgggaa ggggcgggag cacctaggtg ttgcaatgcc 1546 aggtccatcc aggcacactg cctggcctgg cgtgacctgg acacacactg accccatgcc 1606 agggcactgc tgggcagact ggcttctcct gccctgccca gtggcttggg gtcaggcttg 1666 ccctcccgct gggaggccac cctgtgtcac agtgtgtccc agatgtcacc ttcctccctg 1726 cacttctatg tgccgttatt ccattattta cttaaatgct ctctttaaat tgacgcattg 1786 caagattgag aatttgtttc agtgctttac aaacagcatt ttcagttgcc atggaaaggc 1846 tatgctggta aggctgggat gtgggagaga gctggtaggg acccctgccc ggtgacatgt 1906 ccagatgtga tcaggagggt cagagaggac ggagacgagg acagtttctc aggtgtgact 1966 agggtaactt agtgcccccc tgaggttacc tcgctctggc aggagcctgg gcccctcctc 2026 tgaggactcc tgcatttcac atctctgggc tgggggtcca cagggcactg acgtgtcctg 2086 ggatttgaaa gccccatcta tgtctgagtc cagtggctga gccagtactc cctggggcca 2146 ctgagagggg tccgggcatg gtccactgtg tctggggatt cagcagcccc tggattgaac 2206 tccataaagc aagtgcaaga tcaaggaaag gacaat ggaa gtgaccttta gacaaacgtt 2266 tgggcatcac aatcactgtc tttcataggg tggcctagcc ttaggtctgt tggggtggtg 2326 ttggggcatg gtctgctgtg gacgctgctg cccagggcac gttctgcgtg tgtggagcta 2386 ttgcaagtct ggtgttgcca ggcttcttaa tgtctgccag atgtgtgggg ataatttgtc 2446 tatcatgtgt atgatgatgt gcattttcct gatttctaat gaatttgagt atccattcta 2506 taattatgaa gagctgatga acagctcttg gttggctcta aagctgcctg tgaatatcgt 2566 atatttgtcc ccactctctc tgttttgcag cagctctgaa aaagggcagc ccctggacct 2626 tgtctaggac ctagacccag caagcctctg gtgctgctgg ccaggctctt gtctctcttg 2686 tctccagtgt cctgagcctt gcctgcctcg tcctggctct taactggctc ctccacccat 2746 gtggaaggtt tcctccctcc agctccatcc tcagaactca acagtccagg cccacttctg 2806 atcccatatc aacgaccaag atgagaaaaa cggtgttctt tccctcaaag atctaacagc 2866 ctagtggggt ggcagcaggg ggactgacag ctgttcccac atagcatgtg ccataaacta 2926 gattcatggg tggagtcagg aaaggcttca cagagcagga ggtggctgaa ctgagtcttg 2986 agggatgaat aggagttcgc cacatggata taggaaggcc tttcaggcaa aggctgtagg 3046 tctttacaga tcatagcttg ttcagaaaac caatcatcca t tcatgcact taacaaccat 3106 gtgttgagca cctcctgtgt tccaggcatg gttctagatg ctggggacac agcagtgagt 3166 gagaaggtct ctgaccccat agaggggtca agagtagagg agagagacag acaaagagca 3226 agaaagatga tcaccaagga aacgacacag tcagttaggt gctacatgcc agggaagaat 3286 gggtgaaggt ggcatggggc tggggcagat gagcagtagg agagccacac atatatagaa 3346 gcttcgaggg agagacagag cacctcacag gccagtgggg acgggcaggc tatcagggat 3406 ggcaccggga tgagcaactc cttatatgga caacaatcaa attagatccc tcttcacagt 3466 gtgaactctt cctggaacat gccagggtac tgaaaaacga aagctagtat ttatgctata 3526 atgtgggctg gcccgtgctg cccagcagaa ctctcagctg cctctcagct gtctgtgttg 3586 tccagggtgg cagcctctgg ctgctcatgg tgctgaatgg cacttgaagt gtggctcatg 3646 cagccaggga gctgctgatt taattgaact gaaatagcta ccctggccca tggcaccatg 3706 ttgcacacac acccccaaag gctggtggtg cccatttgct gtgcatctgt gcaccttctc 3766 atggaagtct cattccatca aaccacatta tgggttattt cacagatgtg tacacagaga 3826 ggggaggtcc catgtcccag gtcacacgca gccagtcagc attagagctg agatgccaag 3886 ctctcagcca cacatgtgca ctcacctgga acatctgtgg agctgt taga atcgctgcca 3946 cttttcatga aactgaagtg catctttggg tttgcaacta aagaaaccag ctgctacaat 4006 gtcactaaca taggattcaa aagcccttcg gatttctggc agtctgtgca tagcaccctg 4066 cctcgggagt tggctccttg tctagtattt aatacatccc caaacttggc tttattttca 4126 gctgcctttg ccttcattgt ggtgaaagat agtgcgggtg actcagatgt ggtggtgcag 4186 gagctcaagt ccatggtggc caccaagatc gccaaatatg ctgtgcctga tgagatcctg 4246 gtggtgaaac gtcttccaaa aaccaggtct gggaaggtca tgcggcggct cctgaggaag 4306 atcatcacta gtgaggccca ggagctggga gacactacca ccttggagga ccccagcatc 4366 atcgcagaga tcctgagtgt ctaccagaag tgcaaggaca agcaggctgc tgctaagtga 4426 gctggcacct tgtggggctc ttgggatggg cgggcaccca agccctggct tgtccttccc 4486 agaaggtacc cctgaggttg gcgtcttcct acgtcccaga agcagccccc accccacaca 4546 tgacccacac cgccctcacg tgaagctggg ctgagagccc tttctcccat ccattggagg 4606 tcccaggagt gtcacccatg gagaggctat gcgacatggc tagggctggt tctgccatct 4666 gagtttggtt tcctggaatg aaaaggcatt gccatctcca ttcctctgcc ctcttgagcc 4726 agcacaggaa ggtgaggccc tgggatagcg cgcctgctca gataacacag a gctagttag 4786 ctagtagcaa ccgtgttttc tccagatctg tctagataca aaggtcagaa atcttatttt 4846 tatactttta tattgtggaa gaacagcatg caacactcac atgtagtgtg tggatttact 4906 tgaacatgtt ctttttaaca tgtagttatg aaaatctcct tttttgcctc tactggtgag 4966 gaaacatgag gatcagaggc cacattttta attattgtta gtgtatttgg aagtctgaat 5026 tggagatgtt tgtacctctg tctaaacagt tcccttgaga acttccaagc ctccggcatc 5086 ttttcctggt gagtgtttct cctgtgcttg gttgtgtata atggagctaa ctcctaagcg 5146 gtggggtgaa tgtggccgcc ttagttctga agctactcca gttatgttct gtttcttcaa 5206 gctgtgatcc agaaagattt ttgtgccccc agatgcctct tgataggaga ggcaacatac 5266 tccaaatagt tgggttcttc agggaagcta ttagaaactc aggtgacttg ttagagcact 5326 aacttggtca gagccaaatc ctggcaaacg ctgcctgacc ttcactctgt ggttggggca 5386 gtgagaacca ctgaggtcca atgatgagac ttggaggtct ggatccagtc tctctttgtt 5446 ttaatgtgac ttaggtgctg tcaacattag caagataatg gaaatcacga cgccagtggg 5506 tgcttacctc cctgctaggc atgcaggggc tggcggttgg caggggaagg aggcccagtg 5566 agccgggtcc cttaggggag ggagagtttg tcctctttgc cccacagtct accctt cagg 5626 gccttgtggc agtgccagtg ttcggggggt gtctgggcca ctgagtaccc actcggtcgt 5686 ggttgtgctg gcctcttggg tgagtgaacc tgtgaagccc aggaggtggt gttggctgca 5746 gggtacacaa atactgagtg gtggtctttt gttacaggct tagcaacaaa gctgtgccct 5806 gggcatgggg ggctgtagtg tagctacagt tgtgcgtttg tgaaatggct tagctttcca 5866 tgttgctgag aggaacctgg acatggtccc gggcatctga atgatctgta ggggagggag 5926 ttcaaataaa gctttatttt gttcattttc 5956 <210> 28 <211> 5868 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2486) .. (3064) <400> 28 gaattatctg ggtccagagc aaaggtggca ctctcagccc tccctggagt ccacgccggc 60 aggtgaagga tcagagcccc atgccccatc cttggggcca ggggctggga cccaggtcac 120 caggagcctc cagttgaagt ggggaggtga ctggggtggt gcagtagtga gccatcccct 180 cacacactgc cagccttgcc cactgtgtcc tccctggccg cccggagctg tgtccgcctc 240 ctgcctggct gcctgtgctc ggcccctcca caagcccaaa acagccctag ggtactcagt 300 gttttcagag ccgcctagat gcaggactgt ttgtgttttg gttttaaatt tttttaatta 360 atttattttt tatagagacc aggtctcacc atgttgccca ggctggtttc aaacccctgg 420 gctcaagtga cctgcccgcc gcagcctccc aaagtgctgg gattacaggt ttgagctact 480 gcacgccact ggttttaaat ttttaaacag aaaacaatat ttacatttcc tctgtctttt 540 tttttttttt tttttttgag acggagtctc gctctgtcac ccaggctgga gtacagtggc 600 gcgatctctg ctcactgcaa gctccgcctc ctgggttcat gccattctcc tgcctcagcc 660 ttctcgtctt ttaaaactga acactgaggt gggttttgtg gtggttggtg aacggacagg 720 tttgggcctg gatcccccac ccgaccctag cacccacagg tggggtcgcc aactctgctg 780 atgtgcctcc tccctcagca ctgtggacct gctggactgg agcagcctca tcgacagcag 840 gaccaagctg tccaagcacc tggtagtccc caatggacag gtaacacctc cgctcctcag 900 tgaggcccag ctcagcaggg cgctgcgcta agaagggaat tcagcctgcc acatgtttct 960 cttgttgcct accctgggaa cttaacatga ccaagatcac tgcacactat ggccccacag 1020 accccctatg gtccaggggg aaaagaagac aaacccacta gtgtccacag agtgcttggt 1080 gggacagaga cccacgcgga gccttaaaac accacaagga gagggggtct gggggccttc 1140 cccaagtcat ctgtcttgtg catcaggtca ccccaaactt cagaggccta aaacggcagc 1200 agccactctg cttctgcctc atggttctgg ggttgacagg gctcagctgg gcagtcctcg 1260 cttggggtct cctgggtagc tgtactcaca gagtggtggc gctgggacct gggggaggcg 1320 cccactcaca tgtctgggag ttggtgctgg ctgtggcttg ggctttttcc caacatggca 1380 gctgggctct aagggccagt gtcccctgag acgtgagagc caggcagaag ctgggtgacc 1440 ttttcctgcc tcacctcaga agtcacacgg tgtcttttct ggcaagttct gtttgttaga 1500 agcatgtcac caggccagcc tgtatactgc ggggagagga atgagactca tctgcctgtg 1560 ggaggggggc ccaggacctg gctgactgct tgaaaccaca acctaaactg gaattcgaag 1620 aaagaacaga agcaccttca gaaaacatcc tgcagaggca gctttccatg acacatctag 1680 ccccagtcca ctaaggg ccc agcctcaaac tcagagcccc cgacccagag cctcggggcg 1740 cagtgcgtac agtgtggctg tgcaccaagg ccaccagctg ttggagactt tagcatggtg 1800 tagcaaggga tagagtggta ctgcttgtgc ccagtgaggc aaggctgctg gggccagcaa 1860 aggggtgagc gggaggccct gcgggatggg tccccacggc ctctgagcac cagctccttg 1920 aaggcctcat cctggcggtt gccctggtcc ctggctacgt gtcagcacgt gctgcacaac 1980 tgccctgtct gcctgtagcc aggggtcttc ctcctgggcc ctcttcctgc tctgggtgga 2040 gcccttctgt ttgacgattg ggtggtcagt gttcacttcc tcagtgtcac atgggagctg 2100 cagggggccc tcccacaatg gtggggcctc tgtgagaact ggggaggctg ttagagtaca 2160 cacttcggag tgcaggcctg gactgagcct ggggcccact gacatgggca ctgagctccc 2220 tcctggtacc cccagggccc gcgtagggca gtgcactggc tgcgttggag gttccggggc 2280 tctgtgctgc ttgtccaggt ggccctccct cccggccctg catgagaggg ttcccgtggg 2340 ctgggaacac taagagaggt ttagcctggg cctcagggtg gcacttcctg gcccttgctg 2400 tggcctgacc atgtgctgta cccccagaca ggacagctgg agcccctgct gtcccggttt 2460 gctgaggagg aggagctaca gatga cga gga tgc tac agc gga tgg atg tcc 2512 Arg Gly Cys Tyr Ser Gly Tr p Met Ser 1 5 tgc cca agg cga gct gtc ccg ctc ggg cag agg gct ggg gcc ttg ggg 2560 Cys Pro Arg Arg Ala Val Pro Leu Gly Gln Arg Ala Gly Ala Leu Gly 10 15 20 25 acc cgg gac tca tgc aga aga ggg cac ctg cct cac ttg agc aat agt 2608 Thr Arg Asp Ser Cys Arg Arg Gly His Leu Pro His Leu Ser Asn Ser 30 35 40 tgc tcc cac tct ccc acc ccc tgc gcc tct cag aaa gcc aca gag atg 2656 Cys Ser His Ser Pro Thr Pro Cys Ala Ser Gln Lys Ala Thr Glu Met 45 50 55 ggc gtg cgg ctg atg gtg gat gcc gag cag acc tac ttc cag ccg gcc 2704 Gly Val Arg Leu Met Val Asp Ala Glu Gln Thr Tyr Phe Gln Pro Ala 60 65 70 atc agt cgc ctg acg ctg gag atg cag cgg aag ttc aat gtg gag aag 2752 Ile Ser Arg Leu Thr Leu Glu Met Gln Arg Lys Phe Asn Val Glu Lys 75 80 85 ctg ctc atc ttc aac aca tac cag tgc tac gc gc gat ag tat gac 2800 Leu Leu Ile Phe Asn Thr Tyr Gln Cys Tyr Leu Lys Asp Ala Tyr Asp 90 95 100 105 aat gtg acc ctg gac atg gag ctg gct cac cgt gag ggc tgg tgt ttt 2848 Asn Val Thr Leu Asp Met Glu Leu Ala His Arg Glu Gly Trp Cys Phe 110 115 120 ggg gcc aag ccg gtg cgg ggc gca tac ctg gcc cag gag cga gcc tgt 2896 Gly Ala Lys Pro Val Arg Gly Ala Tyr Leu Ala Gln Glu Arg Ala Cys 125 130 135 gca gca gag atc gga tat gag gac ccc atc aac ccc atg tac gag gcc 2944 Ala Ala Glu Ile Gly Tyr Glu Asp Pro Ile Asn Pro Met Tyr Glu Ala 140 145 150 acc aac acc atg tac cac agg tgc ctg gac tac gtg ctg gag gag ctg 2992 Thr Asn Thr Met Tyr His Arg Cys Leu Asp Tyr Val Leu Glu Glu Leu 155 160 165 aag cac aac gcc aag gcc aag gtg atg gtg gcc tcc cac aat gag gac 3040 Lys His Asn Ala Lys Ala Lys Val Met Val Ala Ser His Asn Glu Asp 170 175 180 185 aca gtg cgc ttc gca ctg cgc agg taggtgtgcc ccaccctgca ccgaaacccc 3094 Thr Val Arg Phe Ala Leu Arg Arg 190 aacctgagcc gttgtctcct ccagctgggg agaggtggca gcagtgcaga gctcagggtg 3154 ggcagagtga cctgctgggt ggtcgggcat ttgtggggaa aggctggtga aatgagctgg 3214 agggtggctt cagtgggcag gcccaggccc gctggcattc tggacatcgg actgtgagag 3274 cacaatggct ctttgcagtt acgttggttt ttaaaattaa cttttttttt tagatagaat 3334 ctcgct gtca cctatgctgg agtgcagtgg cgtggtctca gctcactgca acctccgctt 3394 cccaagttca agcaattctt catgcctcag cctcccaagt agctgggatt acaggcatgt 3454 gccaccacgc ctggctaatg ttttgtattt ttagcagaga cagggtttca ccatgttggc 3514 caggctggtc tcaaactcct ggcctcaagt gatcctccct tcttggcctc ccaaagtgct 3574 gggattacaa gcatcagcca ctgtacccag ccttttaaaa attaacattt gacttattaa 3634 acttcacaat taaaaaacta aatttcatca gggtattcgg atggctcctg aaaggtacaa 3694 atgtagtgtt ggagcccagt ccctcaggag gcctccacag cgctgcctca tttataagca 3754 gttcccttaa cattttaact acatctggaa tgtaacggtt tgttttctct ttaaacattt 3814 gtcccatgga gcacaacttc ggtagaattc taacaagtca aatgcagaag ttaggtgaag 3874 tcagttcttg gatactcctg tactgtcacc ctggtcttat ctcatgcctt agcccaagct 3934 atgcacacaa tggggtccta ggtccccctc ccctcccaga ttccgccttc ccagggatgg 3994 gaccccctag aaccctcgga ggcctgggca gtggcctcgc tggctctcgc cttcctagga 4054 gctgagcagg agctccactc tcagcagggc agggtgcccc agatccatga cttgtggcac 4114 gaaggggctc cccaagaagc tgtgaagcca cagggccagg cttggggcca gggctgcagc 4174 caacaggaca catcctggtg ctgctcggga gctgactcac ggctctgaaa tcattcagtg 4234 atgtccacat tcagcctttg tttacgatgc tgctactttt tcatggcctg aaattgcagc 4294 acacccattt ttgtgccctg atcctctgct aattgtcata gatgtgtcgg tgatgggaca 4354 gactcacttt ctccacacgc acaggcctgg tggccagcac tgcccagcac tcgggagctg 4414 gtgggggttc ctctcagctt gtaatcagga ctcccagcct ctgggtggac tctcaatgct 4474 ggtggactca cagcctgact agacacatca ccatccaact ccgaaaggac agcccgccct 4534 cagcagggct tcctctctcc agcttagccc cggcacctgt ctgtccctac tatcttgctg 4594 tggcagtggc ttccccagtg gacacagctt ccccctcccg agtggcagcc gggctctctc 4654 ctcttggccc caagggccct gtgccgggct cccccagtac catgctcaca tccctgcctg 4714 agaggctgga cccctgcagg cttcagctct gcccctgctg tgggtggctg gggagctctg 4774 gggagctggg gtcccctccc atgggtaagt ggttctagac tatggcagct gctctgtcct 4834 gtgctgggcc cagactgcca caccacccac cctcaaacaa cccgagttgg ctttggccaa 4894 ggaacaaacc agccccaaac ttagaggctg gaacagtggc atgttctgta ggccaggggt 4954 gggctggctc agctgatgct tctgctgctg gctgtgcctg tgtccctcct gcgtctgtga 5014 tctggggccg gtgggg ccta atgagctcat tcatggctgg tgtagtaaag gagactacat 5074 cctgggtcca gcgtcccaca ggccagccca ggcttgggca cgtggtgggc tcaggcttcc 5134 agaaggcctg gagagggcaa gcctctgctt gtgtcacctt tggtacctcc ctgttggcca 5194 aagtgcctca cgaggccaag cccagatccc aggtggagtg agccactgtc ctgtgctggg 5254 aggagccgca gtcacatggc agaggctgtg cacaccagca ggggaggggg cagccagcag 5314 tggcacccgg ctctcgggtt catgtcctgg ggttgaggaa gacacaagat ggaagccagg 5374 gcgatgtggc agagatgggt gcctgcttta gactgggtgg tcccgacact ggagcccagc 5434 ccagggatgg agggaaaggg cctctggccg atgggtactc tgggagccag ggctggggca 5494 gatggagaac aggggaggtg aggccctcgg ggagggagtg ggaagcacag cacaggcact 5554 gccagtcacc cgggtgatgc gtgagcagca ggcggaactc gccccaggct gggggaccca 5614 gtgctgtgca gaccagcgaa gtcgggatac ctggatatag taagctggag atgaaacttg 5674 agaactgtca ctgcgtggat atttcaaacc ctgagaatct ttgtaagacc ctatacgggg 5734 tggtgtgaag acaggacaga gtggaggccc caccccagta tctgagcagt gctaatagat 5794 gtataatgca agccacatct gtaatttaaa gttttttggt agctacgtta aaagataaaa 5854 tgaatttcaa gaat 5868 <210> 29 <211> 5983 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (137) .. (1000) <400> 29 gtccgggtaa ctgcggagga tccgagggtc aggctgcaga agcccagaat cccaccccag 60 tccccaagta cagaggtcgc tgtcaagatg gagtttccaa cccagtaaat ccaagggcca 120 gaccgtgacc tcataa ag cc gc atg atc tc gc atg atc tc gc atg atc tc gcc atg tc g gcg gca ttc aaa ttc tgc ccc tac tgt gga aat tct ttg cct 220 Ile Gln Ala Ala Phe Lys Phe Cys Pro Tyr Cys Gly Asn Ser Leu Pro 15 20 25 gta gag gag cat gta ggg tcc cag acc ttt gtc aat cca cat gtg tca 268 Val Glu Glu His Val Gly Ser Gln Thr Phe Val Asn Pro His Val Ser 30 35 40 tcc ttc caa ggc tca aag aga ggg ctg aac tcc agt ttt gaa acc tct 316 Ser Phe Gln Gly Ser Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser 45 50 55 60 cct aag aaa gtg aaa tgg tcc agc acc gtc acc tct ccc cga tta tcc 364 Pro Lys Lys Val Lys Trp Ser Ser Thr Val Val Thr Ser Pro Arg Leu Ser 65 70 75 ctc ttc tca gat ggt gac agt tct gag tct gaa gat act ctg agt tcc 412 Leu Phe Ser Asp Gly Asp Ser Ser Glu Ser Glu Asp Thr Leu Ser Ser 80 85 90 tct gag aga tcc aa a ggc tcc ggg agc aga ccc cca acc ccc aaa agc 460 Ser Glu Arg Ser Lys Gly Ser Gly Ser Arg Pro Pro Thr Pro Lys Ser 95 100 105 agc cct cag aag acc agg aag agc cct cag gtg acc agg ggt agc cct 508 Ser Pro Gln Lys Thr Arg Lys Ser Pro Gln Val Thr Arg Gly Ser Pro 110 115 120 cag aag acc agc tgt agc cct cag aag acc agg cag agc cct cag acg 556 Gln Lys Thr Ser Cys Ser Pro Gln Lys Thr Arg Gln Ser Pro Gln Thr 125 130 135 140 ctg aag cgg agc cga gtg acc acc tca ctt gaa gct ttg ccc aca ggg 604 Leu Lys Arg Ser Arg Val Thr Thr Ser Leu Glu Ala Leu Pro Thr Gly 145 150 155 aca gtg ctg aca gac aag agt ggg cga cag tgg aag ctg aag tcc ttc 652 Thr Val Leu Thr Asp Lys Ser Gly Arg Gln Trp Lys Leu Lys Ser Phe 160 165 170 cag acc agg gac aac cag ggc att ctc tat gaa gct gca ccc acc tcc 700 Gln Thr Arg Asp Asn Gln Gly Ile Leu Tyr Glu Ala Ala Pro Thr Ser 175 180 185 acc ctc acc tgt gac tca gga cca cag aag caa aag ttc tca ctc aaa 748 Thr Leu Thr Cys Asp Ser Gly Pro Gln Lys Gln Lys Phe Ser Leu Lys 190 195 200 ctg tca aca agt gga aga agc tgt act cga ccc cac tgc tgg cca tcc 796 Leu Ser Thr Ser Gly Arg Ser Cys Thr Arg Pro His Cys Trp Pro Ser 205 210 215 220 cta cct gca tgg gtt tcg gtg ttc acc agg aca aat aca ggt tct tgg 844 Leu Pro Ala Trp Val Ser Val Phe Thr Arg Thr Asn Thr Gly Ser Trp 225 230 235 tgt tac cca gcc tgg gga gga gcc ttc agt cgg ccc tgg atg tca gcc 892 Cys Tyr Pro Ala Trp Gly Gly Ala Phe Ser Arg Pro Trp Met Ser Ala 240 245 250 caa agc atg tgc tgt cag aga ggt ctg tgc tgc agg tgg cct gcc ggc 940 Gln Ser Met Cys Cys Gln Arg Gly Leu Cys Cys Arg Trp Pro Ala Gly 255 260 265 tgg tgc gta ccc agat tca gct gcc gcg tca ggg agg gca cat 988 Trp Cys Val Pro Arg Ser Cys Ser Ala Ala Ala Ser Gly Arg Ala His 270 275 280 cac atc cta gtt tagcaggcac tttagtcatt gacacttccg gcccccaccc 1040 His Ile Leu Val 285 cccctgcc gg cccctgcc gg ccacgcc atgatgggtg gtcagtcctg tggagggccc ttggggggcc atgagcattg gaggaaggag 1160 ccccggcctc aaactgaagg cttagattag gcttcctggt ggagggtgttt tctaagccaa 1220 gactctcagg atgagtggaa atagcaaagt gctgggtgga agaggaagag gatagatgag 1280 gagaggatgg tccggccaag gatacagctg gggcaaggct tgtgtggaag ggagagcata 1340 tggcatttgt tcattagttc attcattcat ccccattaaa tattcatcag gcacttgctg 1400 ggtgccagac gctgtccccg gggctgggtg cagagcaggg agcagcataa acatggtttc 1460 tgtgtcttag agctcacagt ctagtgggag gggccaatag tgaatcaaac agttgcacaa 1520 actatgacaa gtgctctgaa tagaagcggc ccctgctgtg attgagagta agagggccca 1580 gtttgcatcg ctggagggat ggacgtacca agggagcgac atgctgagtc ctaaggtctt 1640 tatgttcagt atctgcagta tggcactgca gtgcggaaga gatggagttg gtctggagag 1700 gtcagcggtg accacatcac acggggcctc gcacagcagg ctgaggggct gggatctgtc 1760 ttgagggcac tggagagcca caagagtgct gggattaggg gagggcgggg tcagctctgg 1820 gtacagaaag gccctcaggg gccatatggg gagggactgg aatggggaga agaatctgag 1880 tgagggtcca tgtgggagag gacaaggctg aggagggtcc cgggccccgg gggtggagag 1940 tctataggag gagaacgagc agaatttggt ggacagtaga gccctggggt caaagagggt 2000 tggggatatg atcagaatgt agctgacact caggcagcag acacaatcaa agaatt ggcc 2060 gggcgcagca gctcatgcca gtaatcccag cactttggga ggacgaggca ggtggatcac 2120 ttgagctcag gagttcaaga ccagcctggg caacatggca aaatgccctc tctaataaaa 2180 atacaaaaaa ttagccgggt gtggtggcac ccacctgtag tcccagctac ttgtgaggct 2240 gaggtgggag gatcacctga gcttgggaaa tcaaggctac agtgagcagt gattgtacca 2300 ctgcactcca gcctgggcaa caggagtaag accctgtctc aaaaatatat atatacacac 2360 agcaaaaaaa gagtctggag ctcataggga cagctggagc tggagatcaa gatataaatt 2420 gcttaacaag atttatttct gctctctagg acaggtgaga agagctcttt gatatccaca 2480 ggtgctgagt catttttgca gagagacatt aacccctttt ccctctgctg agtttgtcat 2540 cagctaagag agaaatacag gagtagatag gaagccacgc tttagctcaa ttgatgagct 2600 tcctgagagc ctgattagag gcgtgctcaa tgtgctgtca cagcgggctc ctcatgctac 2660 cccggattta gtcaggttta acccccagtc acagtgtcgg acaaccccag gccttaatag 2720 tggggctccc tcctggtctg caccatagcc tctctgtgtt agtcgtactg ctcatgcaga 2780 cactgacttg cttcttcccc cagctggatg ccctggagtt cctccatgag aatgagtatg 2840 ttcatggaaa tgtgacagct gaaaatatct ttgtggatcc agaggaccag agtcaggtga 2900 ctttggcagg ctatggcttc gccttccgct attgcccaag tggcaaacac gtggcctacg 2960 tggaaggcag caggagccct cacgaggggg accttgagtt cattagcatg gacctgcaca 3020 agggatgcgg gccctcccgc cgcagcgacc tccagagcct gggctactgc atgctgaagt 3080 ggctctacgg gtttctgcca tggacaaatt gccttcccaa cactgaggac atcatgaagc 3140 aaaaacagaa gtttgttgat aagccggggc ccttcgtggg accctgcggt cactggatca 3200 ggccctcaga gaccctgcag aagtacctga aggtggtgat ggccctcacg tatgaggaga 3260 agccgcccta cgccatgctg aggaacaacc tagaagcttt gctgcaggat ctgcgtgtgt 3320 ctccatatga ccccattggc ctcccgatgg tgccctaggt ggaatccagg tgggaagagc 3380 ttgtgaggct taagcctctc accccttgcc ctcacccgag ccctgcccca ggctccagga 3440 gacacttccc agaggctgtt ccacgttcat accagggccc agcttcccag ggagacactg 3500 ggtttttccg cacggtcctt gaacttccca gcctcaagga atggcaagta gcagaaaccc 3560 ggctcaactt ggctttaaga aaagtgggga ttgattggct gttgtagcta gaaaattaca 3620 agggggagct tcaggcacaa cgggattcag ggcctcaaaa atagcatcaa gacgttgttt 3680 gtctctcgcc atcttctgtc ccttcttgca tccatgcctc cctctgtcct tccacccggc 3740 cacctgtagt ctctactttc ctttggcctg gcccccttgg cgcccccata cacaaaaggt 3800 agctgctcca tgccttcggg tctcgttcat agtgcgcact accccttcct gtggatgacg 3860 gacactcctc acagccagca gctgggcgtt tgcttagttt cccagatttt tattttacca 3920 acagtgctgc ctgtgtgcac agcccggctg ctggcgcacg ctgtctgtgg atggaggtat 3980 caacttgaca gtgctgacta gatggcttta cttccatcag cactttgtgt aaacgtgcag 4040 gaatttttac aaggtcaaag acagactaca cagtaaattt tggcaagggt gcagagatgt 4100 gtgctgaaga ggagcttctc caggctcctt ttctctcccc ggagtagtca tttctctcat 4160 cggagttggc tggaaccaaa gctcagtgct ttgtctgatt tggcaccacc ctgggggcat 4220 ttggcagtgt ctggagacac ttggttgtca ggatgcggga cagtggaggc cgggatgctg 4280 cctgacatcc tgtgacatgc agcacggtgc ccacctgtac caccccacaa agaatccccc 4340 ggccccgtgg tcagcagcac cacgattgtg agatcctagt cgcagggcat cttgaacagc 4400 atctcctttt gacggcctgt ctcccggcgc agcgacgttc ttcttggcgc ttggattaca 4460 agtgcttctg cattcccaca acgtttcctt acatctgagg ctgaaacctg agctgacacg 4520 tgtgtgtcaa gcgattcgtg gagcacctgc gcacagagtg ggccagtggt gaggggtggg 4580 gactct tttc tccgtggtgg agtagcaggc tctctgcctc aaccagtggt gccgagagta 4640 aagtcatgac ctgtgccaat ctccctcttt cccccacctc tccagctcga tacacagctc 4700 ctccgtgtac ccagttatcc aggccagaca gctcggggtc ctccccaaca cccttgctcc 4760 cccagcagcc tcctccaaac cttcggtccc gggtgagact gaccacgggg tcacttgtca 4820 cagtcttctg ctggcagcca gctcctccag ggcagggtcg cgtctgactc tgtcatctct 4880 gcttttctgg catggcacag ggcagaggct tcatcctgtt tatcgatgga gcgagcccag 4940 gcttcccgtc gtcagtgcca ctgtgtctca cagtgccttc ctcacccagg gcaaagggca 5000 tttagaacct gacacctgac aacctcccag ggtctccacc gtctcacacc cacgcgctcc 5060 ctggaggcca ctcactcagc cccttggttg ggaacataac gaggagatgg catttaagga 5120 gcccagtgat cttcgagcac cttgaaggtc atcttgcctg tgctccacag cagctccttg 5180 ccttggcccg aggccgagct cccttcctcc cccgtgcacg atgcaccagc cacacccccg 5240 cccctctgat tctagaccag gccaagctgg accccacccc ggaacctttg cacctgccat 5300 cccgagttct ggaaagctcc cctcatcctg gctttatgta cctgctgctt ctcaagaccc 5360 gaggccttcc ccatcctcca tgaggcatcc tcactgcctc cccacccact tgctcatcat 5420 gtcacctgtt ttccacacag cccttgttcc catctggagg gaagcgtgtg tttagtgtgt 5480 agtctccacc cgcctcctcc tcatcctaag cccagcaggg gctcctcatc ccgtatggtc 5540 atgatgacat ccccagtacc tagaagatga catccccaga acctagaagg tgcttggcat 5600 gaagtgaagg catagagggt gttccttgaa tgaatgagac actaacagca tttttattgt 5660 cttccagaac tttccatttg cagtgtgcaa cagaaaaaaa aaaatgaagt aatgtgactc 5720 aaggcctgct gtttaatcac agataagctt ctagaacaag ccctggaatg tgcattcctg 5780 ccactggttt caggatactc atcagtcctg attagcctcc cggagggccc cagtttccct 5840 cccgtgaatg tgaagttccc catcttggtg gcctgccctt cagccagtgt cctagcaaag 5900 ctggatgggg ttgggccggc ccacaggggg gacccctcct acccttgaca cctctgtgct 5960 ttggtaataa attgttttac cag 5983 <210> 30 <211> 6440 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (396) <400> 30 aaa tac tgc tgc aac gag acg gag ttc cag gcg gtg atg cag gcg aac 48 Lys Tyr Cys Cys Asn Glu Thr Glu Phe Gln Ala Val Met Gln Ala Asn 1 5 10 15 ctc acg gcc agc tcc gag ggt tac atg cac aac aat tac acc gcc ttg 96 Leu Thr Ala Ser Ser Glu Gly Tyr Met His Asn Asn Tyr Thr Ala Leu 20 25 30 ttg gga gtg tgg atc tat gga ttt ttc gtg ttg atg ctg ctg gtt ctg 144 Leu Gly Val Trp Ile Tyr Gly Phe Phe Val Leu Met Leu Leu Val Leu 35 40 45 gac ctt ttg tat tac tcg gca atg aac tac gac atc tgc aag gtc tac 192 Asp Leu Leu Tyr Tyr Ser Ala Met Asn Tyr Asp Ile Cys Lys Val Tyr 50 55 60 ctg gca cgg tgg ggc atc caa gga cga tgg atg aaa cag gac ccc cgg 240 Leu Ala Arg Trp Gly Ile Gln Gly Arg Trp Met Lys Gln Asp Pro Arg 65 70 75 80 cgg tgg ggg aac ccc gct cgg gcc cct cgg ccg ggt cag cgg gcc cca 288 Arg Trp Gly Asn Pro Ala Arg Ala Pro Arg Pro Gly Gln Arg Ala Pro 85 90 95 cag ccg cag cct ccc cca ggc ccg ctg cca caa gcc cca cag gcc gtg 336 Gln Pro Gln Pro Pro Pro Gly Pro Leu Pro Gln Ala Pro Gln Ala Val 100 105 11 0 cac aca ttg cgg gga gat gct cac agc cca ccg ctg atg acc ttc cag 384 His Thr Leu Arg Gly Asp Ala His Ser Pro Pro Leu Met Thr Phe Gln 115 120 125 agt tcg tct gcc tgaaaacgct tttgctgtgc ctcaggtgg gaga Serga 130 atctgaagca cccggtgcag cctccgagaa gaacaacttc tacagagatg ccagggacag 496 ccgaggtagc ggcggtggca caggaggaaa tgctgcctgt gcccaaagcc cccttccgcg 556 gacttctaag attaggagca aactcagggg taggggctgg gggtgcaggg gaggggattc 616 tgagccacct gtccgcaagc aatagtccta ttttgggctg gtggcttctg agaggtgact 676 cattgtggac tcaggatgac caagacaaag caactctggc tgattccagc caggaggatt 736 gaggcctgtg agttatacct gtggttgaaa accgaagctt cccttgcccc tgctccctcc 796 agtagtggcc ccttggggct atttgtgtca gaatattgaa tgtgcgtgtg tgtgtgcgtg 856 tgtgtgattt ggggtgttct ttttgtttgc ttggttggtt ggtttttatt ggggcttccc 916 ccctcaagtt ctctgatggg catgagtcac cctccggctg ggggttctca tccgtgtcaa 976 tgtccgagcc gcaagcttat tgctaagcac agggtacggc ccctctgtgt ctcggggagc 1036 actggggatt tgaaaatgcc agtcagggtt gtttcttaca gaattcgttc ctgtaacaat 109 6 agtaatacta agggctgcat ctcaggctga ccacagggca ggtgccaagt taagtgtttt 1156 catgcactcc ctctctcacc acctgggagg caggtatgat taaccccctg cagaaaaact 1216 cacagtgggg aagcggtgcc ggaacccaaa gtccaggctc caactccctg gacgtgacat 1276 gctcgccagc cggggtacac cctgcacaat gctgggagca tctccttgat gcctccacca 1336 tcaccgcctg gagcgctgat ccactcagca cattctggct aagcatctgc tgtgtgccag 1396 gccccgtgct gggcagtgat gggaatgaaa gatgagttag atctcatctc tgcccccggg 1456 gagcctccca tctggtggga gacacagaca cgtggatctt tgctggaaag ggtaacaagg 1516 ccatggaaac ccaggcagga gcgttctaga aatccatcca ctttcaagta ggacttccat 1576 gcccgtaaca tccacccacc gagctaatca cccccactcc tgccccgctg ccctgggaca 1636 cctatgagat ggcatcacct aaatcatcac aaacatctcc aaaggccatg ctgccagtgt 1696 agacacactc attccatggg tgttagtgat accaaatctc ccccagctct tagctcggga 1756 ggccctgctt gatcaatgtg tgtgtcctct gacgcagttt cctcatttca tcagacctag 1816 tgttctcaca ctgaccaccc atccattcac cagacacgac agtgagcaag gcaggtccct 1876 gctcactgtg ctagctttct agctggggca ggaagacagt gaagaaggaa ggtggcgaag 1936 gca gtgagtg ctctgccggg aactcagtgc caggaactca gttcgaggga cacgtgagtg 1996 agacccttgt ggacctgggg tggtctggga aggccgcctt gagcagatga ttgaagccca 2056 gatttgaatg acacacagga gccagtaatg ggcgttaaag ataggaaaag agcattccag 2116 gcagaaggaa cggctagtgc aaagatcctg cggcagccac aggcttggtg gtttcaagga 2176 agcacaagaa agccaggtgg cacaagaaag ccaggtggct ggggacccag agggaaggca 2236 gaaggagatg agggtgatag tgcccagctc tgggctctgc tgtgagtcaa gctgtgcaaa 2296 cacaatgtcc tgcctttgga aaagcagaac aaacttgcta gggcataaag catcctccat 2356 tctgcctggc tgtccatcct ctcaacagcc ccatgaagaa ggggctctcc ccattttatg 2416 gacaagaaga cagactcagc tgggtcaagt ggcttgccca ggatcacaca ggtcagctgt 2476 ggaagaccca ggcccctggc ttcagtcttt gggtccagct gtctcctcca ggcagtgctg 2536 ccagtgtcca ggcatatggc ttggcaaagt gggagaacct ctgcttgggg tctcgattgg 2596 agaaaggaat ggcttcctct cccctgatgt gagccgtccc agggccatgt tgccgtaagg 2656 gggtgcacag cctgtccact agcccagctg cggaagccac agctgtgtcc cacgtgcagt 2716 gcctcagaag gcagaggaag ccttgaggtg ggggcccaag acccagattc tgacatcagc 2776 tctgccac tg agaacagcgt gacctcaggc aaggtctgtt acctcagttt ccccatcggt 2836 aagaggaagg agtcagatgg gtatttaagg agtttgcaac cctcgtgtcc tgctgtcctg 2896 gacaatgctc tgtaggtgct tcctctgcca aaaaggaact ggtggccttg cctccctctc 2956 ctggacacct ggggtcaaag gtcactgcca aatagacagc tagaactggg gttcacctaa 3016 gcatcccttg agatgtacaa ccttctagga ggacattcct cctgcctgcc cccctccccg 3076 caagaggtct tttcaggaat aactgaaaaa cccatggggt ttgtggtcct gctgctctgc 3136 caagtccctc ttgggcagct gggctgagga ctggaacatt ctgtggcaag caggaggcct 3196 cagcagagat caccaagacc cagcacacct ggtacagaca gcctgcggca aaggcaggtg 3256 cagagtgcag acagccacgg catcctcctt cctgcaggtc acccccacga gccacttaac 3316 ctctcagagc ctctgcttct cacctgtcaa gtgtgtgagg tagggtacca gttagtcacg 3376 gtacttgctg tctcacagag gagccgacag gtgagaacag tgtgcatgtg ggtgtgaaca 3436 ctcagtgtgg aaagcaggtg tgtgtgtatt caatccccca atggtgtcaa gggctcctca 3496 aaatgccatg ggtccccagg tcattgtgat aaacactgtc cccatcctgc tgtggttgtg 3556 gctggaaggt ccctcaagga gtagactgtc cctgagaaca agatggatgc agggtagtga 3616 cgagttcaag cat agctaga gttactgttt tttagcaact caacctgatt ttttaagctg 3676 cctactttta ctttttactg tgagcttctg tccatcacca tgtaatttgt aataataata 3736 atacaaaaag aaaaacgaga gagagaagag gacaagatgt ccacagagga atctgcattc 3796 gaggctgttt gcagaactac cgcgtttgta aggactgttt cccactggga actgtgtgta 3856 attaatgagc agttttatgc tttccctctc gtctgtgtac ggtgtgattg ttgtgtgttt 3916 cagaatctct attcagaacc aatagctggt aatgcctgct ggctcgctgc cctcaagtta 3976 gcctctgaac gtgccctgca cctagagaag cagccttctc acccgcctca cctggctgct 4036 ccagcggcca ggccagccac ctgaccatga ccattgctga tgtgcaacag gccttaattg 4096 aaaaaacaca caagtacata catgcacatg cgcgcacaca cacaggtgat ttcacaggta 4156 gatctggtcc ctcttgctgt ctccaatgct ctagaaagca gcaagtaggc agctgacagt 4216 gttcccaggg tgagtggcat ctcccctcat catcagaaag attcagtcaa attttggccc 4276 agagctgaag aggaggactt gggaatgtca gggaaaacat gacagggcta ggggttaaca 4336 ggcttctttg gccaggagat ggtttccagt tcaccgtcaa cccaaaagct ctcttcaggt 4396 catggcaaac agaccagggc tgtgggtgtg gctgtgcttg gcactgactc ccccacaggc 4456 cgctgtccag gttggctc ag gattccagct gccatcccca ggcaggcccc tccgctggct 4516 cggctgcttt cacaatcacc atgtctgtct attagagact gtgccattca aggagacggg 4576 gtccccgggg gtgcagactt gtaaaatttt ttaatttttc aacttggctg aactggtccc 4636 catcaacagg aaaagccttc ggaagtgaat ttacagattt ctcccatgtt tgaaattaac 4696 ataacatgaa cccagaaggc agagcttgca gtgagctgag atcgcaccag tgcactccag 4756 cctgggcaac agagtgagac tctgtctagg taggtaggta agaaggaagg aaggaagaac 4816 agacctggat ggagttattg ggaacatgtc ttatcaatgt tgaagggccc cctatcactg 4876 tagggagaca tccacgtggg ttgttttcgt ctgctgtgaa aatctagggt tggaatcatg 4936 gaagcaaact gcaggaattc ttaatcatcc tgctcacgtg gtgggcatca gagggtgtct 4996 gcttggcccc cacagcactg ggacagtcag agaggccatg agtggatgac gccctgatca 5056 ctgccctttg cagtccagga atacctcact gggctggggc cataccctgt gccctctgga 5116 agacaagcct gcgcacttac tatgtgccag atgccatgca cagtgcccta gttccttgct 5176 gtagcaccaa cacgtcccac gctggtgctt aaatgcacgc aaacaacttt ggtggttgtg 5236 gcccgaaaag ctcaaatgtt aaagttaagc agtcaggcaa gctagaagag gtgaggagcc 5296 tcctagaaaa ctcattcgat gac acgcgct tccctcacct attcagatac ttgccgagtg 5356 cctgccactt gcctggccct gtacccaggg cctatctggg agccattcct gctatagctg 5416 ggaccacttg tgaaacggct agttgtgcct aacagacatg ctcagattca caaaatgaat 5476 tcagaacact tacctgtccc acccgtgaaa gtgaccttgg aggtgtcatt gccccccacc 5536 accccagttt ctagtccaag ccaacagctg gtgctagata gatgcttgat gaatgagcag 5596 atttgactgt tagttactct gtacctaaaa ctcctatctt tacatcaaag ccctgacaga 5656 tttgcccttg acagactgaa atccggggct gctgcagggt tcacctccag gaggcaccat 5716 tcacgacact gtcccataaa tggtaatggg ctcccaggga tactgtttac atagactgca 5776 ctgagaacgg tgacccttag gtttgtacaa tgaggtaccc tgttgaatga ccctaaacca 5836 gcctccaaaa tgtgcaggat cccacattgg tcagcgccaa ccctgagcac aggatctaaa 5896 actatagatg atatggccac cctggccaca gctggaacca agctggtggc ccaagagaga 5956 gcctcttctt ggaattgcat gtcagtttct catacgcagt ttcttcctat ttttcccatt 6016 tcccgtttta aagctagtgg catacctcac agtcaaataa ccaagtggtc agtgtctcga 6076 caatgtgcag taacgaggtg ggggctgcaa gggtgagggg ctcagtcacc ttaacaaggc 6136 aggagacctc ccacaaaagg ctgatgtg tc gtccccaggg ccagctggac aagggcatgc 6196 agcgcagggg tagggggatg gaaatatttt ctctcccgta aactctgact tcatgtgagc 6256 aggcatgggg tctccctgag agctgataac cgggaaaacc aaaaccaata atattcctaa 6316 taataatact agaatgtaag aataatcatg tgtttttcac tgaccgctgt tgctctgctt 6376 ttgtctttat atacagtagt ttttataaca atgtccctag gttttaataa aggagtgtca 6436 tgtc 6440 <210> 31 <211> 5307 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (679) <400> 31 a cgg aac cgg cgg cgg gag tcg cgg tcc cgt tcg cgc tcc acc aac acg 49 Arg Asn Arg Arg Arg Glu Ser Arg Ser Arg Ser Arg Ser Thr Asn Thr 1 5 10 15 gcc gtg tcc cgg cgc gag cgg gac cgg gag cgc gcc tcg tcc ccg ccc 97 Ala Val Ser Arg Arg Glu Arg Asp Arg Glu Arg Ala Ser Ser Pro Pro 20 25 30 gac cgc atc gac atc ttc ggg cgc acg gtg agc aag cgc agc agc ctg 145 Asp Arg I Phe Gly Arg Thr Val Ser Lys Arg Ser Ser Leu 35 40 45 gac gag aag cag aag cga gag gag gag gag aag aaa gcg gag ttc gag 193 Asp Glu Lys Gln Lys Arg Glu Glu Glu Glu Lys Lys Ala Glu Phe Glu 50 55 60 cgg cag cga aaa att cga cag caa gaa ata gaa gaa aaa ctc atc gag 241 Arg Gln Arg Lys Ile Arg Gln Gln Glu Ile Glu Glu Lys Leu Ile Glu 65 70 75 80 gaa gaa aca gca cga aga gta gaa gagat agg gtg gag 289 Glu Glu Thr Ala Arg Arg Val Glu Glu Leu Val Ala Lys Arg Val Glu 85 90 95 gaa gaa ctg gag aaa agg aag gat gaa att gaa cga gaa gtt ctc cga 337 Glu Glu Leu Glu Lys Arg Lys Asp Glu Arg Glu Val Leu Arg 100 105 110 agg gtg gag gaa gcc aaa cgc atc atg gaa aag cag ttg ctc gaa gaa 385 Arg Val Glu Glu Ala Lys Arg Ile Met Glu Lys Gln Leu Leu Glu Glu 115 120 125 ctc gag cga cag aga caa gct gca ctt gcc gct aga gag 433 Leu Glu Arg Gln Arg Gln Ala Glu Leu Ala Ala Gln Lys Ala Arg Glu 130 135 140 gta acg ctc ggt cgt ttg gaa agt aga gac agt cca tgg caa aac ttt 481 Val Thr Leu Gly Arg Leu Glu Ser Arg Asp Ser Pro Trp Gln Asn Phe 145 150 155 160 cag tgt tgg gtt ctg cct cct gct cag ttc aga aag aga tgg aat aca 529 Gln Cys Trp Val Leu Pro Pro Ala Gln Phe Arg Lys Arg Trp Asn Thr 165 170 175 gac tat cta att cct ttc tcg tct aaa ctt aac att gct gcg aaa gtt 577 Asp Tyr Leu Ile Pro Phe Ser Ser Lys Leu Asn Ile Ala Ala Lys Val 180 185 190 aat ttt tta gcc tat tca gaa gtg ctg act gat aac tta aaa gtt gga 625 Phe Leu Ala Tyr Ser Glu Val Leu Thr Asp Asn Leu Lys Val Gly 195 200 205 agc ttt tat aaa aca tat tca agg ata ctt ttt gat tta atg gaa ctg 673 Ser Phe Tyr Lys Thr Tyr Ser Arg Ile Leu Phe Asp Leu Met GluLeu 210 215 220 gct att tgagaagtgt ttgaaacttt tgccatggct gcaggactta cattcttttt 729 Ala Ile 225 tgggaggacg gtggggagac agggagtggt aaagggaaaa ggttaaaaat ccacctgtgg 789 ttgtatattc ttctattctg tcactctgtt acctagactg tgagaggctt ttgccttcag 849 tcagattaaa aagagcaggg cctaacattg agtgatagca cctgctttga taaataggtt 909 ttctcactct tctttttttc cttcttttat ccctcactcc ctcccctaaa ccctgcttca 969 gcacaatgga ctaattctag cattctgatc ataaggccct ccattttcct aatgtgtttc 1029 aaggaatctt tttaggaaaa atatccagat tattcatcca ctttttttag tatctactaa 1089 caactccttt ttttctctag agagttatga aggaacaggt tgtccttgtc tggagtcaag 1149 ctaaacacat gatttgtttt atcagcagct ggagcagaag ttgaaaatgt ctttctgtga 1209 gacagtaatt tgctactgaa gctttatggc ttgtttgcac tgattactcc aggatccaaa 1269 aacttggtga aagtcactga aacactcaag gcaaattact ttacagccct gagtgtctgt 1329 caccatagtt tgcataatga atatgaatcc cattggtgtg tgatgtagga aatcctgtag 1389 ttgtattttc ttgaactgaa atatttgact caaaataatt aagactcatt gtcatttttc 1449 atcttggcat tattgtggac aagttgacat attaaatctc tttgctttct g gtaagctta 1509 gcttttaaaa tgcattttcc cttgtcctgt ctttaactag atatacatgc ttatatttat 1569 agtgggtttc acagactata aaattgaatg tatgaaattt ttatttatat cagtgctttt 1629 aataatgaag atatttttgg agtaatggtg ctgtcttgta gcgagttatt aatcatagta 1689 agattttttt ctcttcattt gctttttttg tttcatatta acaatttttt tttttacacg 1749 gacacaaccc tctgacagtc tttccaaata ttaaaatcat ttgaatatgt atgctgtgat 1809 ctgaacactg ctcaagccat caagcagtct tcatacagtt tgcattataa aatctcatta 1869 aattctccaa gaaaaaataa gttgaagaat tttatttcct gaccatgcat cccctggatt 1929 tctgagtttc agttcagatt gtagatgaca atataagctg ccttccgaaa ttgtcaacat 1989 ctgaatgtta agtccatttt ccccatggaa gaagcccgta gttccatgaa gtatggatta 2049 ccatttgtat ttttcactaa cagtaaatgt atttttctta ttaattgttt gccttaggaa 2109 tgatgaatta cattttttgt tccttcttac cataaacatc tgcattcctc agctcagcct 2169 tccttgtatg ttgtttcttt ataaatggtt gagctgctga tgcaggtatt gccaagctaa 2229 cagtacaaat cattttaaag aggaagctgg cgcgtatggc agccgaggag cacactctgc 2289 aggacactgg acaagacagt aaatattcaa cttttaatgc tgattaaagg agtata ggta 2349 aagaatacgt aggtatacat aattggtgag acaaatattc actttattta tattttatat 2409 attatttttt taatttggta aatactatcc agttttgtag ttgtccttgt tgatttgtgt 2469 gatattaaag tattagtaat aattgccagg aaactatcat tagggagggt ttagttggtt 2529 gctgtttgga ctgggaggga tgatttaaat ttagtgctag aaaccaattt tagtgactgc 2589 acagtttatc atttgtcaga cagaaggtag ctataaagct accctgtaag tcatatcaaa 2649 aaagttcaga ggaagattag taaatattta tcaataaaaa taaacatttt gtttttctaa 2709 tatcttaaca tatcctcccc tttaggagga agaacgtgca aaacgtgagg agctagagcg 2769 aatactggaa gagaataacc gaaaaattgc agaagcacaa gccaaactgg ccgaagaaca 2829 gttgagaatt gttgaagaac aaagaaagat tcatgaggaa aggatgaaac tagaacaaga 2889 acgacaacgt caacaaaaag aagaacaaaa aattatcctg ggcaagggga agtccaggcc 2949 aaaactgtcc ttctcattaa aaacccagga ttaaattgca aactctgaac tttttacaaa 3009 gaaaaatgga aaaactttgt atggtagctt catgttgaag tggttttttg tttttgtttt 3069 tgttttttta atttgtaaaa tctggaaagt tagcttgttc taataggggc tatgctctgc 3129 aattcccttt tttttttttt ttttccttcc actaagtcaa atccttatca gatcattgtt 3 189 gtattctaag gagtgacgta tttttcacct gtttggattc tatattagtg gtctgaggaa 3249 gagcagatca cattgtaaaa ctatggatgg tctgataagg cttttactga ccccactgac 3309 ttcagagtta tactctgttt gctacatcat aatgctggtt ttgctgactt tttgtttttt 3369 tatatattta taaaaaaaga aaaagttggt gattgcattg ggaaattccc agggtattac 3429 tggacctatg tggtgtattg ttaaaccagt gtccttgtga tactgttgct cttgatgttc 3489 ctgatacagg taaggaaaca gttggtcaac tctgatacaa agtatatata cagttcagta 3549 ttgtctctgt tcattttgtt tttatttcat tgacaaaatc aaaccagcat tccccattgt 3609 gtaaataaat gattttgctg aataaagtaa agtcttaaat tcatatgttg aagcaatttt 3669 ttttaatgtt atgttaagtc ttaaagaggg tggttcactt tttgatggtc aaccatttag 3729 aagtcttaga actatatttc ctcttgttta tacttttaac atagggttta tatgtacatt 3789 aaatatactt gtgaattagt atttaatggc tatttttaca aatatcaact ttatgctgat 3849 agagcaaatg gcatcagtgt tacctttaag aaagactaac aacatccaga agatttaaat 3909 tctcaaacct gtgcctctgt tttaggatat aagtattatc acaaagtata cttaataaag 3969 gctagaaaaa tgcttttaaa ttatggaatc tgagatcgtt ttcagagtgg gccatcagaa 4029 a gaacttagc tttatactgt caaaaaaagg ctaagatggt cgagtcattt tcattgtgta 4089 gtgtacttgc acgtttattt ttaggacaaa cacatttgaa ctttatgaat tttttttttt 4149 tttttttgca tgtgaaatct tatgaatggc tttcatttta tacactagaa tctgcctcat 4209 ttactcttaa catatgttta agtatactgg tattaaaaca ttcaagaaaa ggatattgat 4269 ctaaaatgct acctgagatg cataaacatg tcatcaagta gagaaaatat ttttattttt 4329 gcccaatatt ttttagacag tttgattatt cttaaaaatt gaaaacataa gctaaagaga 4389 tgactaaatg gtagattatt ttgtgtgtgc atgctaggaa aaatgctgtt gctttagttt 4449 tgagctcttc aatgagtcta attgtggtaa ggaacaatat aaaatcagtt taaagatctt 4509 taaaggtaga attttaaata ggcatgaaat atagtgagaa cttttagtaa acatactact 4569 tactctaaaa tcaaacattt tattttccta aagaatatag gttgccaaaa aatattttat 4629 ctctaaatat aggttagctg taattatttc atgaattttt ttttttttca atgtaacttt 4689 ttttggtgaa gattcatggt tcctaagttc tgtattcaag tttttggaaa tgtttattta 4749 aaaactgttc tatacaagtg ttcaaaacat tgtatctaaa gagagtagcc tggacttaaa 4809 atatttgaaa tcagcttatg cgtgcctttt aatttttttt ttaagtttct tactgccaca 4869 tatggtg tga agtgacagta agttgcttaa tgacatcctg cagtatctgc ttgcttttgg 4929 agactccagt gagatgttga aattgttcct gtgcttggta actactttcc tctgccaggc 4989 tatgggaaag aggatgtaat tgtgaataat atacaccatc cagtctttaa tgtgctgcaa 5049 caatgtagta atttgttttt ttcatttgtt cccactgcct ttgtgtacat agaaaactta 5109 aaaatttccc ccagtctatt agaagttaag atgttcccta atttattaaa tatgccttta 5169 ttcacaattt gtttttttag gttattctta atgcattata gaattaagta tgactttgtt 5229 tatttttatt acagtatgta gttattgaca tattgtggtt tgcagaatta tcaattgtat 5289 aaactaaacc tttaaatt 5307 <210> 32 <211> 5415 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (129) .. (824) <400> 32 gcgcagcgtc ggcggggagc gcgggctgcg gagaggcggg ccgggccaag cggagccgag 60 cgagcgggag cgcggcgtcc gggaggcggc ggagacgcgg ggctcggagg gtcagcctct 120 tatcgtag cag gtc tcc tcg gca cgc ccc cct tgt ttc gcc cca cgg cca 170 Gln Val Ser Ser Ala Arg Pro Pro Cys Phe Ala Pro Arg Pro 1 5 10 agc ccg ccg cgg gcc ggc gtg cgc tgg tca ctg agg ccc agg tcg ccg 218 Ser Pro Pro Arg Ala Gly Val Arg Trp Ser Leu Arg Pro Arg Ser Pro 15 20 25 30 ccg cgg cgc gtt ttt gaa atc atg aat cct gtt agt cct gga tct 266 Pro Arg Arg Val Phe Glu Ile Met Asn Pro Val Tyr Ser Pro Gly Ser 35 40 45 tct ggg gtt ccc tat gca aat gcc aaa gga att ggt tat cca gct ggt 314 Ser Gly Val Pro Tyr Ala Asn Ala Lys Gly Ile Gly Tyr Pro Ala Gly 50 55 60 ttt ccc atg ggc tat gca gca gca gct cct gcc tat tct cct aac atg 362 Phe Pro Met Gly Tyr Ala Ala Ala Ala Pro Ala Tyr Ser Pro Asn Met 65 70 75 tat cct gga gcg aat cct acc ttc caa aca ggt tac act cct ggc aca 410 Tyr Pro Gly Ala Asn Pro Thr Phe Gln Thr Gly Tyr Thr Pro Gly Thr 80 85 90 cct tac aaa gtg tcc tgt tcc ccc acc agc ggg gct gtg cca ccg tac 458 Pro Tyr Lys Val Ser Cys Ser Pro Thr Ser Gly Ala Val Pro Pro Tyr 95 100 105 110 tcc tcc tcc ccg aac ccc tac cag act gcc gtg tac cct gtg cga agt 506 Ser Ser Ser Pro Asn Pro Tyr Gln Thr Ala Val Tyr Pro Val Arg Ser 115 120 125 gcc tac ccc cag cag agc ccg tat gca cag caa ggc acg tac tac aca 554 Ala Tyr Pro Gln Gln Ser Pro Tyr Ala Gln Gln Gly Thr Tyr Tyr Thr 130 135 140 cag ccg ctg tat gca gca cct cct cac gtc atc cac cac acc acg gtg 602 Gln Pro Leu Tyr Ala Ala Pro Pro His Val Ile His His Thr Thr Val 145 150 155 gtg cag ccc aac ggc atg cct gca acg gtg tac cct gct ccc atc ccc 650 Val Gln Pro Asn Gly Met Pro Ala Thr Val Tyr Pro Ala Pro Ile Pro 160 165 170 cct cct aga ggc aac ggg gtc acc atg ggc atg gtg gct ggg acc acc 698 Pro Pro Arg Gly Asn Gly Val Thr Met Gly Met Val Ala Gly Thr Thr 175 180 185 190 atg gcc atg tca gca ggt acc ctg ctg act gct cac tcc cca act cct 746 Met Ala Met Ser Ala Gly Thr Leu Leu Thr Ala His Ser Pro Thr Pro 195 200205 gtc gcc ccc cac ccg gtc act gtg ccc acg tac cgg gcc cca gga acg 794 Val Ala Pro His Pro Val Thr Val Pro Thr Tyr Arg Ala Pro Gly Thr 210 215 220 ccc act tac agc tat gtg ccc cct cag tgg tgatcacctg caaatgtttg Pro Thr Tyr Ser Tyr Val Pro Pro Gln Trp 225 230 aggacggagc tgtgcagtca cattattggg gattccacag ctggtgctgc aggccttgcg 904 cctccaacca ggactttctt cttaatgctc tcgacactta gctaaacacg actatatccc 964 ggcccagcag gccccagcgc cgttagtctc cagctgactc tgtgggttgg tcttaaagca 1024 aattctgttt tgtggactgc ctggcaattt tttagctaac tgtaatgata aaaagggagt 1084 attaatctat tctgaatcat atctagttga atgcatgttt aaaaaaacaa acacaaaaag 1144 cttgctcaat ctacctgcag tgactgatgc aaaaccatca tatgcaaaat ccaaaggaat 1204 ggaaacgtat tttacaactt gtatcactaa tgcactgttg taatgtatgc aaagtcttac 1264 agttataagt gttaaagtga atttcttcat agagcatctg aaatatctta gatgattctt 1324 caaccttttg gggttgatgt gggttgccag ttagggatgt ggacatttta gttttcagcg 1384 acctgtttct ttggcactga ctgtcctggg agggagttgc gaggtttggg agagagtagg 1444 gaagccacag ctgcttgggt gcagctgg tt catggacatc cctttgagtt taggcttggt 1504 ggagtcagtg gaacagggac atgcttaaag ctcatcatga aagattatgg tagtgtggcc 1564 agtgaaattt ggggcgaggg gggtggttta tgtgtcagca aagcagtttc tctgctatct 1624 aaattttcat tacagttctc ttagagagat gatgttttta tatgtcttta ttggaaaagt 1684 cctatgtaaa actaaattat tttcctggga tggaagaaat gtgaaagaga aacagccatg 1744 cttgcaggag gtattgtcct ctgctttatt tagcttagaa aatcattcct tttttttttt 1804 tttcctggag aaatgtttga atcagctgaa aacaggtagg cattgctgtt tttccccaac 1864 aaagaagggc aaaggtttca gctgtatgtt atgaagaaag tggtatattt aagaatgagt 1924 taaaagggaa caaaacttta tttaaaattc ctccaatttc ttgtagaaag gcagggccgt 1984 ggatatgtct ggaaatgtag aaacctgtag ctgcttctgg gatcacccac ctgatggtgg 2044 tgacttgtct gctgaggccg gctggagggg acgcttagag atggggcgag ggggaggcca 2104 gtgtctgttg tctgcgagcc tctcctgcca tctcttttgc agctgagggc acttggcaca 2164 aagcaagcac agacagcaga gagggccagg cagtgctgga gtgcgtttgc tggcagggtt 2224 tattgtggga gaggaatttg agtttaggat ctgaatcttg tacataagaa atgaaaaggc 2284 ttccctccac cccgccccca aaatatgccc gt cctgtatc catgagagtg catgtcggtt 2344 ctcagtgagg gtcagagtgg gggtggggga tgtaaggcct gggtcccttt cagcggcctc 2404 tagggcagga gcgtgcgtct tcttcccagt gcagtggtgg tttgagtgct gtgggctctg 2464 gtggggaggg ggctctgctc ctcttcattt gctggtagct gggtcagggc actggcgccc 2524 agtgaggatg cccactagca ttctgcccca gttggttggt ggggggacac ctgaccactg 2584 agcctttggt aaccttattt tttatagtaa gtacttctta taattttctt tttcacatct 2644 tattttataa gaagtttagg aatatttttg catggatcat tgtaaacagc agattcttta 2704 ttcctgatgt ctattaacat agaatgttta ctgataagta ctttaaattg cttcatgagc 2764 acttaatcca tcttagtgtc tatgtgtggg ggcagacatt taccgcaggc acacagtttg 2824 tgcccctttc ttcaagtctc tgttggtaat tccatctgtt tagtggatgg ttggcaggat 2884 tagtaggttc taacggttcc aggggttcag ctgaccaagt agcagagaag tctttttttc 2944 ccaattgagt gctaatagat taggataaaa tactcacaat gttagtgtat gcttttaaaa 3004 agccccacac aacaaaatgg aaacatacat gtacaactcc tgtgagggct ggagtcttgg 3064 ggttcaggag gaggttagaa gttacaggca tctcttcagg cttgcttggt acttggcaca 3124 cacaggatgg tgttttaaag agtgggctgc acccccc aca cgccatttac atcagcttca 3184 taaacacttt tcttcctccc tgtaacttaa ccttttttcc cttttatgaa gttgagaggc 3244 tttatgaaat aagtttgcat tgcacatccg tgcagaaatc tttctgactt tgaaattttt 3304 aggacgtcag ctgtcagata cgaaaggtag atatcaggta agaatctgga cttaggaaat 3364 agtcacaaaa ctgtcatagg ttgtaatttt atcaacattc gcttctagta aaattaaagt 3424 caattaagaa atagaacttg ggtcaaaatt ctgttacaaa gcttcataat ttgtcccgaa 3484 gcatatggtg gagcattctg agaaatttgc tttttgtgtg tttgacattc ctaatttggg 3544 agtccttcag ctgaattact attcttttag aagttgagac agcaggtaag caaaggacct 3604 agttcatgta aacatggaca tcatgatggc tatttaaaaa atatttgttc tacaccttct 3664 cccctgaggc ttggggagtg tgttcagccg ctgcagtttc tctgctcatg gaggtcttgt 3724 ttggatctgt gctggcggct gagcatttag tgtgagccag tgacccatga acttgccgct 3784 ctgtgagggc cagagtcagg gccagtcatg gtaatgggcc tgaaggcact tccagaacct 3844 tttatgtctc tcgtgagcca tctgttaaga acgttcttct tggtgtggtt tgtaggccta 3904 cctgtcgcta ttctgggaaa ccttcttgag tgctatgcaa atgtgttcac aggcaatggg 3964 ggtggtcctg agccttgggg tgggcacctg gtcagtgagt gt cttgccct tccccagctg 4024 ggcatacagt accttgctct ttctggtggc atcatctggc tgtgatgaat gaggtctagg 4084 aaataatttg catgtgtctt gggggacaca acagtaacga gaggaaatac attattacag 4144 caacttgcga cgtactaata cctgtcagtg ttggcccccg taaggtatgt aaggcacctg 4204 tgagtgccag tgagtgctgg tgaaaggcca acatgtacta gttatgtaag tattggtgtc 4264 tgctttaaaa aaggagaccc agacttcacc tgtccttttt aaacatttga gaacagtgtt 4324 actctgagca gttgggccac cttcacctta tccgacagct gactgttgga tgtgtccatt 4384 gtcgccagtt tggctgttgc ccggacagga caggacctcc attgggcgca gcagcaggtg 4444 gcaggggtgt ggcttgaggt gggtggcagc gtctggtcct cctctctggt gctttctgag 4504 agggtctcta aagcagagtg tggttggcct gggggaaggc agagcacgta tttctcccct 4564 ctagtacctc tgcatttgtg agtgttccct ctggctttct gaagggcagc agactcttga 4624 gtatactgca gaggacatgc tttatcagta ggtcctgagg gctccagggg ctcaactgac 4684 caagtaacac agaagttggg gtatgtggcc tatttgggtc ggaaactgca tgtttcagaa 4744 agtttgtctc tttttcctac tcattatttg aagaagagag agcctgtggg gatagcctta 4804 tcttggtcca caggactgaa gtgaagtcac ttgggaaggg gagacag agg atgagcggcg 4864 tctgtgtagg gacccccccc cgggcctgca gaagggtggt gtgctcccag gactggcatg 4924 acaggtgtct cctcctcacc acaggctgtg cccatgagtc cctgtgcaga ccagtgggca 4984 aggcagctgg gccagatctc aggccagccg tttgtgctcc tagcagggtt gctgtgctgg 5044 ccacacggag aggccctaga gagcctcatg gattgtaact aaagaagaaa cggttccttt 5104 ttgttttttt aaaaatgatt tttaaatacc gttttttaca ccgttctctc ggtacttttt 5164 ttaagctaag tcagcattgt cttccagtgt taaaggcatc cctcacctct gcattgaact 5224 tacgtatcca tgccaaggaa tggaatttcc atcctgagcc agttcagtta ggtgtcaatt 5284 gatactattt taatttttta tgcaatctga tgagatgagc tcagatttaa aaatctcaaa 5344 agcacgttta ttgtaacaag aattgttatg tattaatact gcagttttca ataaagattg 5404 acttgtgttg c 5415 <210> 33 <211> 5878 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4167) .. (5285) <400> 33 caggtcggtg gtacacatgc tgttgcaggc gtgcaggtcg gtggtgttac acactttcac 60 gctgttgcag acgtgcaggt cggtgctgtt acacacgctg ttgcaggcgt gcaggtcggt 120 ggtgttacat tcacacttgc aggcgtgcag gtcggtgttg ttacacactc atgctgttgc 180 aggcgtgcag gtcggtggtg ttacattcac gctgttgcag gtgtgcaggt cggtggtgtt 240 acacacattc acgctgttgc aggcgtgtag gtcggtggtg gtacacacat tcatgctgtt 300 gcaggagtac aggtcggtgg tgttacattc acacttgcag gcgtgcaggt cggtggttac 360 attcacactg ttgcaggcgt gcaggttggt gttacattca cacttgcagg cgtgcaggtc 420 ggtggtgtta cacacattca tgctgttgca ggcgtgcagg tcggtggtta cattcacact 480 gttgcaggcg tgcaggttgg tgttacacac attcacagtt gcaggcgtgc aggtcagtgg 540 tgttacacac tcacacttgc aggcgtgcag gtcggtggtg ttacacacat gctgttgcag 600 gcgtgcaggt cggtggtgtt acacacattc actgttgcag gcgtgcaggt cggtggtgtt 660 acacattcac gctgttgcag gcgtgcaggt cggtggtgtt acattcacgc tgttgcagac 720 gtgcaggtca gtgctgttac acacgctgtt gcaggcgtgc aggttggtgg tgttacattc 780 acactgttgc aggcgtgcag gtcggtggtg ttacacacat tcatgctgtt gcaggcgtgc 840 aggtcagtgt tacacacatt cacgctgttg caggcgtgca ggtcggtggt gttacacaca 900 ttcacgctgt tgcagatgtg caggtcggtg ctgttacatt cacgctgttg caagcgtgca 960 ggtcggtggt gttacattca cgctgttgct ggcgtgcagg tcggtggtgt tacacacatt 1020 cacactgttg cagacatgca ggtcggtgct gttacacaca ttcatgctgt tgcaggcgtg 1080 caggtcggtg gtgttacatt cacacttgca ggcgtgcagg tcggtggtgt tacacacatt 1140 catgctgttg caggcgtgca ggtcggtggt gttacacaca ttcacactgt tgcaggcgtg 1200 caggtcggtg gtgttacatt catgctgttg caggcgtgca ggtcagtggt gttacacatt 1260 cacgctgttg caggcgtgca ggtcggtggt gttacacaca ttcacgcttt tgcaggcgtg 1320 caggtcggtg gtcttacatt catactgttg caggcgtgca ggtcggtggt gttacattca 1380 cactgttgca ggcgtgcagg ttggtgttac acacattcac acttgcaggc gtgcaggtcg 1440 gtggtgttac acacatgctg ttgcaggcgt gcaggtcggt ggtgttacat tcacactgtt 1500 gcaggcgtgc aggtcggtgg tacacacatt cacactgttg caggcgtgca ggtcggtggt 1560 gttacacaca ttcatggtgt tgcaggcgtg caggtcggtg ttacacacat gctgttgcag 1620 gcgtgcaggt cggtggtaca ttcatgctgt tgcaggcgtg caggtcggtg gtgttacaca 1680 ttttcacgct gttgcaga cg tgcaggtcag tggtgttaca ttcatgctgt tgcaggcgtg 1740 caggtcggtg gtgttacatt cacgctggtg caggcatgca ggtcggtggt gttacacaca 1800 acgctgttgc aggcgtgcag gtcagtggta cacacattca cgctattgca ggcgtgcagg 1860 ccggtggtgt tacattcacg ctgttgcagg cgtgcaggtt ggtgttacac acattcacac 1920 ttgcaggcgt gtgggtcggt ggtgttacac acattcatgc tgttgcaggc gtgcaggtcg 1980 gtgttacaca cattcacact tgcaggcgtg caggtcggtg gtgttacaca cattcacact 2040 gttgcaggcg tgcaggtccg tggtgttaca cacatgctgt tgcaggcgtg caggtcggtg 2100 gtgttacatt cacactgttg caggtgtgca ggttggtgtt acacacattc acactgttgc 2160 aggcttgcag gtcggtggtg ttacacacat tcacacttgc aggcgtgcag gtcagtggtg 2220 ttacacacat tcatgctgtt gcaggcatgc aggtcggtag tgttacacat tcatgctgtt 2280 gcaggcgtgc aggtcggtgg tgttgcacat tcatgctgtt gcaggcatgc aggtcggtgg 2340 tgttacattc acgctgttgc aggagtacag gtcagtggtg ttacacacat tcatgctgtt 2400 gtgcagctat cacttccatc tccagagccc ttttcatctt aaaactgaag ctctcccatc 2460 acacagtgac ccttcatgtc cctccccagt ccctgaaaaa cactgttcag gtttttcttc 2520 ctggacctca ttgtgtggag tt cctcgtgt gagtgcagtc acacacgatt tgtccttttt 2580 tttttttcgt ttgttgagac agagtctcat tctgtcactc aagctggagt gcagtggcgt 2640 gatctcagct cactgcaacc tccactccca ggttcaagtg attctcctgc ctcagcctcc 2700 caagtagctg ggattacagg cgcctgccac cacgcccagc taatttttgt gtttttatta 2760 gagacagggt ttcaccaagt tggccagact ggtctcaaac tcctgacctc gtgatccacc 2820 cgcctgggcc tcccacagtg ctgggatgac aggcgtgagc taccacaccc ggctgattta 2880 tccttttatt tgggctcctt tcactcagcg tctttaagct tcatacgcga aagatgcttc 2940 agagattcct ttttcaggct gaatatctgc tgcgtggcta ggccactttt tgtttaatcc 3000 tctctcctct ggtggacacc aggactgtgc tgttttggtt gctgtaagcg cgggtgcaca 3060 cgcctgcctg aggctgtgtt ttggccgttg tgagtgtggg tgcacacacc tgcctgaggc 3120 tctgctttgt tgtgagtgcg ggtgcacaca cctgcctgag gctgtgtttt gggtgttgtg 3180 agtgtgggtg cacacacctg cctgaggctg tgttttgggt gttgtgagtg tgggtgcaca 3240 cacctgcctg aggctgtggc gcgatctcgg ctcactgcaa cctccacctc ccgggttcaa 3300 gcgattctcc tgcctcagcc tcccgagtag ctgggaccac acccaccacc acaccccgtt 3360 atttttttgt atttttagta gagatgg ggt tttgccatgt tggccaggat ggtctggaac 3420 tgacctcagg tgatccaccc actggcctcc caaagtgctg ggattacagg tgtgagccac 3480 tgtgcccggc ctctttttac tttgttaatg gtgtattttg atagataaca gattgtcatt 3540 ttcatgaagc acagctggtc agtttattgt tgctcatgta tttggcctca tgttcgagtc 3600 cctgttttta atcatgagct ggacacagcc ctctttagag caactgtgac cacttgtggt 3660 gagaagtgca gcccacacca tccacgtgag gctcccatgc agacatttag aaggcgtttt 3720 cactgcagct cagaaaatgg ccccaggccc ccatgggcac ccccatgtca ccagggcctc 3780 tggttgctgc cggtacacag ggataggcag ccaggcctcg aaggtgctgg gcatgggttt 3840 gggtgtctgc gttgggtaga gacccggagc gcccttgctg ggcgtgccct aacatcccgg 3900 taccctgtgc ccctctgtgg gccaggacgc ctggtgctgc cagctgggcg taagccctga 3960 ggagctgagg gtggctgtga tttggaggat gagtaggagc tcaccaggag ggcgtggagc 4020 cgaggcgttt aatatcatca ggagcaacac tgggctcaga aggcaggcac acttgccgtc 4080 cctccagagc catggctgac ggccaggcct ggtgggctct cgtgaggaca gtgcctgtgg 4140 ttgtcagatg ctgtcccttc gagtaa ggg atg aga gcc atc ctg aag atg ggt 4193 Gly Met Arg Ala Ile Leu Lys Met Gly 1 5 cag ctc tgt ggt gac cac ccg ttg gga gca gtg aca ttc agg tgc gtt 4241 Gln Leu Cys Gly Asp His Pro Leu Gly Ala Val Thr Phe Arg Cys Val 10 15 20 25 gca ctg gtg gct gtg tgg ctg tgt ggt g gc g acc agg agc cat gtg 4289 Ala Leu Val Ala Val Trp Leu Cys Gly Thr Ala Thr Arg Ser His Val 30 35 40 ggc aag gac agc tgt ggg ctg ggc aca gag ctc tct ctg ctg gga gtc 4337 Gly Lys Asp Ser Cys Gly Leu Gly Thr Glu Leu Ser Leu Leu Gly Val 45 50 55 agt cgg tgc tgg ggc gag ggg agg cag agc tca cag agc ccc tct aca 4385 Ser Arg Cys Trp Gly Glu Gly Arg Gln Ser Ser Gln Ser Pro Ser Thr 60 65 70 gct cac cct gca gct cgg ccc tgg cca gta aac cca cca tcc ccc ttt 4433 Ala His Pro Ala Ala Arg Pro Trp Pro Val Asn Pro Pro Ser Pro Phe 75 80 85 ctg ccg cag gag gca gtg gag aag gtg aca cag cac atc cac ggc ctg 4481 Leu Pro Gln Glu Ala Val Glu Lys Val Thr Gln His Ile His Gly Leu 90 95 100 105 tct ggg aag aag gat ggg ctg gtg ccc atg ttc atc aat acc cac agt 4529 Ser Gly Lys Lys Asp Gly Leu Val Pro Met Phe Ile Asn Thr His Ser 11 0 115 120 ggc ctc ttc acc cac ctg ggc gta ttc acg ctg ggc gcc agg gcc gac 4577 Gly Leu Phe Thr His Leu Gly Val Phe Thr Leu Gly Ala Arg Ala Asp 125 130 135 agc tac tat gag tac ctg ctg aag cag tg cag ggc ggg aag cag 4625 Ser Tyr Tyr Glu Tyr Leu Leu Lys Gln Trp Ile Gln Gly Gly Lys Gln 140 145 150 gag aca cag ctg ctg gaa gac tac gtg gaa gcc atc gag ggt gtc aga 4673 Glu Thr Glu Leu Leu Glu Val Glu Ala Ile Glu Gly Val Arg 155 160 165 acg cac ctg ctg cgg cac tcc gag ccc agt aag ctc acc ttt gtg ggg 4721 Thr His Leu Leu Aru His Ser Glu Pro Ser Lys Leu Thr Phe Val Gly 170 175 180 185 185 gag ctt gcc cac ggc cgc ttc agt gcc aag atg gac cac ctg gtg tgc 4769 Glu Leu Ala His Gly Arg Phe Ser Ala Lys Met Asp His Leu Val Cys 190 195 200 ttc ctg cca ggg acg ctg gct ctg ggc gtc tac cc 4817 Phe Leu Pro Gly Thr Leu Ala Leu Gly Val Tyr His Gly Leu Pro Ala 205 210 215 agc cac atg gag ctg gcc cag gag ctc atg gag act tgt tac cag atg 4865 Ser His Met Glu Leu Ala Gln Glu Leu Met Glu Thr Cys Tyr Gln Met 220 225 230 aac cgg cag atg gag acg ggg ctg agt ccc gag atc gtg cac ttc aac 4913 Asn Arg Gln Met Glu Thr Gly Leu Ser Pro Glu Ile Val His Phe Asn 235 240 245 ctt tac ccc cag ccg ggcgt cgg gac gtg gag gtc aag cca gca gac 4961 Leu Tyr Pro Gln Pro Gly Arg Arg Asp Val Glu Val Lys Pro Ala Asp 250 255 260 265 agg cac aac ctg ctg cgg cca gag acc gtg gag agc ctg ttc tac ctg 5009 Arg His Leu Leu Arg Pro Glu Thr Val Glu Ser Leu Phe Tyr Leu 270 275 280 tac cgc gtc aca ggg gac cgc aaa tac cag gac tgg ggc tgg gag att 5057 Tyr Arg Val Thr Gly Asp Arg Lys Tyr Gln Asp Trp Gly Trp Glu Ile 290 295 ctg cag agc ttc agc cga ttc aca cgg gtc ccc tcg ggt ggc tat tct 5105 Leu Gln Ser Phe Ser Arg Phe Thr Arg Val Pro Ser Gly Gly Tyr Ser 300 305 310 tcc atc aac aat gtc cag gat cct caag aag cct agg gac aag 5153 Ser Ile Asn Asn Val Gln Asp Pro Gln Lys Pro Glu Pro Arg Asp Lys 315 320 325 atg gag agc ttc ttc ctg ggg gag acg ctc aag tat ctg ttc ttg ctc 5201 Met Glu Ser Phe Phe Leu Gly Glu Thr Leu Lys Tyr Leu Phe Leu Leu 330 335 340 345 ttc tcc gat gac cca aac ctg ctc agc ctg gac gcc tac gtg ttc aac 5249 Phe Ser Asp Asp Pro Asn Leu Leu Ser Leu Asp Ala Tyr Val Phe Asn 350 355 acc gaa gcc cac cct ctg cct atc tgg acc cct gcc tagggtggat 5295 Thr Glu Ala His Pro Leu Pro Ile Trp Thr Pro Ala 365 370 ggctgctggt gtggggactt cgggtgggca gaggcacctt gctgggtctg tggcattttc 5355 caagggccca cgtagcaccg gcaaccgcca agtggcccag gctctgaact ggctctgggc 5415 tcctcctcgt ctctgcttta atcaggacac cgtgaggaca agtgaggccg tcagtcttgg 5475 tgtgatgcgg ggtgggctgg gccgctggag cctccgcctg cttcctccag aagacacgaa 5535 tcatgactca cgattgctga agcctgagca ggtctctgtg ggccgaccag aggggggctt 5595 cgaggtggtc cctggtactg gggtgaccga gtggacagcc cagggtgcag ctctgcccgg 5655 gctcgtgaag cctcaggtgt ccccaatcca agggtctgga ggggctgccg tgactccaga 5715 ggcctgaggc tccagggctg gctctggtgt ttacaagctg gactcaggga tcctcctggc 5775 cgccccgcag ggggcttgga gggctggacg gcaagtccgt ctagctcacg ggcccctcca 5835 gtggaatggg tcttttcggt ggagataaaa gttgatttgc tct 5878 <210> 34 <211> 5429 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (919) <400> 34 c gaa ggg ggc ggg gtc ggc cct ggg cga ccc gct gag ggg agg gcc gcg 49 Glu Gly Gly Gly Val Gly Pro Gly Arg Pro Ala Glu Gly Arg Ala Ala 1 5 10 15 ggc cgc cgg gga ctg gag cat ggg acg gcg cgc ctg aag gag cag gaa 97 Gly Arg Arg Gly Leu Glu His Gly Thr Ala Arg Leu Lys Glu Gln Glu 20 25 30 ggg gaa gga ggc ctg gga ccc cga aaa gag aag ggg aga gcg agg gga 145 Gly Glu Glu Gly Pro Arg Lys Glu Lys Gly Arg Ala Arg Gly 35 40 45 cga gag cgg agg agg aag atg caa ctg act cgc tgc tgc ttc gtg ttc 193 Arg Glu Arg Arg Arg Lys Met Gln Leu Thr Arg Cys Cys Phe Val Phe 50 55 ctg gtg cag ggt agc ctc tat ctg gtc atc tgt ggc cag gat gat ggt 241 Leu Val Gln Gly Ser Leu Tyr Leu Val Ile Cys Gly Gln Asp Asp Gly 65 70 75 80 cct ccc ggc tca gag gac cct gag cgt gat gac ggc cag ccc 289 Pro Pro Gly Ser Glu Asp Pro Glu Arg Asp Asp His Glu Gly Gln Pro 85 90 95 cgg ccc cgg gtg cct cgg aag cgg ggc cac atc tca cct aag tcc cgc 337 Arg Pro Arg Val Pro Arg Lys Arg Gly His Ile Ser Pro Lys Ser Arg 100 105 1 10 ccc atg gcc aat tcc act ctc cta ggg ctg ctg gcc ccg cct ggg gag 385 Pro Met Ala Asn Ser Thr Leu Leu Gly Leu Leu Ala Pro Pro Gly Glu 115 120 125 gct tgg ggc att ctt ggg cag ccc ccc aac cgc ccg aac cac agc ccc 433 Ala Trp Gly Ile Leu Gly Gln Pro Pro Asn Arg Pro Asn His Ser Pro 130 135 140 cca ccc tca gcc aag gtg aag aaa atc ttt ggc tgg ggc gac ttc tac 481 Pro Pro Ser Ala Lys Val Lys Lys Ile Phe Gly Trp Gly Asp Phe Tyr 145 150 155 160 tcc aac atc aag acg gtg gcc ctg aac ctg ctc gtc aca ggg aag att 529 Ser Asn Ile Lys Thr Val Ala Leu Asn Leu Leu Val Thr Gly Lys Ile 165 170 175 gtg gac cat gg aat ggg acc ttc agc gtc cac ttc caa cac aat gcc 577 Val Asp His Gly Asn Gly Thr Phe Ser Val His Phe Gln His Asn Ala 180 185 190 aca ggc cag gga aac atc tcc atc agc ctc gtg ccc ccc agt aaa gct 625 Thr Gly Gln Gly Asn Ile Ser Ile Ser Leu Val Pro Pro Ser Lys Ala 195 200 205 gta gag ttc cac cag gaa cag cag atc ttc atc gaa gcc aag gcc tcc 673 Val Glu Phe His Gln Glu Gln Gln Ile Phe Ile Glu Ala Lys AlaSer 210 215 220 aaa atc ttc aac tgc cgg atg gag tgg gag aag gta gaa cgg ggc cgc 721 Lys Ile Phe Asn Cys Arg Met Glu Trp Glu Lys Val Glu Arg Gly Arg 225 230 235 240 cgg acc tcg ctt tgc acc cac gac gcc aag atc tgc tcc cga gac 769 Arg Thr Ser Leu Cys Thr His Asp Pro Ala Lys Ile Cys Ser Arg Asp 245 250 255 cac gct cag agc tca gcc acc tgg agc tgc tcc cag ccc ttc aaa gtc 817 His Ala Gln Ser Ser Ala Thr Trp Ser Cys Ser Gln Pro Phe Lys Val 260 265 270 gtc tgt gtc tac atc gcc ttc tac agc acg gac tat cgg ctg gtc cag 865 Val Cys Val Tyr Ile Ala Phe Tyr Ser Thr Asp Tyr Arg Leu Val Gln 275 280 285 aag ggt tgc cca gat tac aac tac cat agt gat acc ccc tac tac cca 913 Lys Val Cys Pro Asp Tyr Asn Tyr His Ser Asp Thr Pro Tyr Tyr Pro 290 295 300 tct ggg tgacccgggg caggccacag aggccaggcc agggctggag ggacaggccg gg gag catg gg ggacaggcgg ggacaggcg gg gttgggcctc aggcagggag 1029 gggggtggag acgaggagat gccaagtggg gccagggcca agtctcaagt ggcagagaaa 1089 gggtcccaag tgctggtccc aacctgaagc tgtgga gtga ctagatcaca ggagcactgg 1149 aggaggagtg ggctctctgt gcagcctcac agggctttgc cacggagcca cagagagatg 1209 ctgggtcccc gaggcctgtg ggcaggccga tcagtgtggc cccagatcaa gtcatgggag 1269 gaagctaagc ccttggttct tgccatcctg aggaaagata gcaacaggga gggggagatt 1329 tcatcagtgt ggacagcctg tcaacttagg atggatggct gagagggctt cctaggagcc 1389 agtcagcagg gtggggtggg gccagaggag ctctccagcc ctgcctagtg ggcgccctca 1449 gccccttgtc gtgtgctgag catggcatga ggctgaagtg gcaaccctgg ggtctttgat 1509 gtcttgacag attgaccatc tgtctccagc caggccaccc ctttccaaaa ttccctcttc 1569 tgccagtact ccccctgtac cacccattgc tgatggcaca cccatcctta agctaagaca 1629 ggacgattgt ggtcctccca cactaaggcc acagcccatc cgcgtgctgt gtgtccctct 1689 tccaccccaa cccctgctgg ctcctctggg agcatccatg tcccggagag gggtccctca 1749 acagtcagcc tcacctgtca gaccggggtt ctcccggatc tggatggcgc cgccctctca 1809 gcagcgggca cgggtggggc ggggccgggc cgcagagcat gtgctggatc tgttctgtgt 1869 gtctgtctgt gggtgggggg aggggaggga agtcttgtga aaccgctgat tgctgacttt 1929 tgtgtgaaga atcgtgttct tggagcagga aataaagctt gccccggggc actggagtca 1989 gagttgtcca aggaaagggc ctcaggcatc ccttggtcca ggaagaattt ctctgatggc 2049 cgcaggacat ttgcttgaga cccaagtggc agggatccaa ccgcccttgg cgctgatgtt 2109 tgctgagggc tcagggcttc cctctccagc cccggttcca agctgtctga tcccccacga 2169 ggaaacttga gcaaacaccc tgggctcggt gctggaggag ggcgtagcat cttcaagaac 2229 agctcaggga gggagagcta gcaggtagaa tgggccaatg agggtgttcc ttggtgtcct 2289 ccctgaactg ccatctgcag acccagcagg gtcctagccc cgtcattttg ctgcgtggcc 2349 ttggccatgt ccattctcct ctctggcttt ctttctttgt ttcttcctct atgacatgaa 2409 gggcttgccc agaccagggg ttctcaaacg cggatcaccc agagggtttg ttaacacaca 2469 gatttctggg tcctacccac atttctaatt cagcaggcct gggtggggcc taagaattag 2529 aatttctaac gagtgcccag gtctatgctg atgctgctgc tccagggccc atgctgggag 2589 acccactcaa aggaccttga agttcatctc tggctatggc tccgcaggag ggggagacac 2649 ctcggatgtg atttcccagc tgtaatttcc atctgcttct cctggggaag gggcctttca 2709 gagaatcggg gctattgtat tggattttca atctgaccac atgccagtga aggaacaggc 2769 tggagtgggg tgtggacaca gggcctgcgt cagtcactcc cctcct gcag ctagtaagag 2829 gcctcagaat ggccagctgc cagtggcacc ttgtctggga gttagttggg ccctttggga 2889 ctctgtgaag ggaagacact accaaggtca cagtgccttc tggaggtcat tctaagtcgg 2949 ctctcttggg agggcagcac tcagggccct ttgggccctc ttgaggagag gagagtcctg 3009 gcagtaaggt aagatgggct tgccaccccc cacctttcgc ccctgcccac cagcgctccg 3069 cgcaaactgg tcccctcata ctgcagcgca gagttgggtg gggctgagaa gccatctggt 3129 tacagcccac cttgtaggaa atgacccagc ttgtttcccc cacatcatgc ttccaggggc 3189 cgtctctcct gagtggagat gtgagacaca cacccctcct ccagaccacc ctccgctccc 3249 caccctggag gcttgagact gctggcactg gagcagccca ccaatggaca cccaccgtgt 3309 gccgttcagc ctcccacagt gctgtggaga ctgcaggaag gaggaggaag caatggggcc 3369 agaggccctg ggcgccctcc ccacctcccc tggctgaact ctcagcaggc actgggggca 3429 ctttgacccc cctcctgctc ctctcctcct gtggagagcc agatgctggc gacagctgga 3489 gggcccggcc ttcctggcac acagttctgc ctgcaccagg gatggattca ttttaataac 3549 ttcatttcac cctcatgcac actgccgcct catccctcct ttccaccttc cccagtagcc 3609 tggctgctct cctcagctag gacttcgcta acagatttcc tcccaaacct taattctttg 3669 gaatagccct ctggtcccta ctgttcttgc cagatacttc tgtgcccgct tggtcctcac 3729 aagggcaagg ggtccatcca acttcctctg gctaagaaga cgtcacctct gccccattgg 3789 cgagcagtgt ccccatggtg atgccccccc accatcacga cgaagtgcgc tggcctccca 3849 ctcttgccat gcacacactc acaggagatt cctctgaaga aacctgtccc cactctgccc 3909 agaccccaaa gggccaggtc ctactcacac tccaacccgt tgaccttccc catccactgc 3969 ccttcaaggc agtctgaaat gccctcagac cgtttagcgg tcccgtggtc ctccacccta 4029 acccctcagc ccagctgggg gctgccgggg gccttgtctc ctccatcagt ggagcctctg 4089 ggacaagttt accaggctgg gggttcttta aggacacagc ttggatctcc ccatcaggct 4149 ggggaacacc tagggccggg ggccatgcct ccctcatcag actgaggaca ccctgatgtc 4209 aggggctgga tggcccctta gactgggggt ccctgagggc agaagctatg cctcccctca 4269 tcagactgga gtctccctga gggcaagaac tgtgctatgg atgggagggg gacagcttgc 4329 cttttcctag gcatcagagc acctggaggc tgcctctgcc cttcagcttt gctcaaaggc 4389 gctgtctggg tctcagcatt cctttctcaa gtagggtgaa tctcctagca ctctgtgaag 4449 ctaataaggg ggattacccg ttaggtcaac tggtagcaat gcccgagtct ccttc tcgat 4509 gaagcttaag gcaaaagcaa atgaatatct aggtcccttc ccccccttcc ccccttccct 4569 ttcctgggat gagcaagcgg gaactgagtc accctgttcc ccatccttgg caggaatgct 4629 ggtgaccttg cattgtggca gattcaggtg gcgaggccca ttgctcgaga tgcacctggt 4689 gggtgggtgg cagggatcct gggggagtgt ttatggggac ggaggcagct gaagggcagg 4749 gaggggtgac caggtgctgg gatcatcgag tgagtatgtg caggagggat tgtagagaca 4809 caatgaaaca gttgctctgt gttgggaagt gatccagtgt catcgctggg agtgggagac 4869 agaaatgtta cttccaaaga ttccgagtcc tgtggtactg ccaggagaac cgggggctgg 4929 ggtgatgggt aaggagaggc accattagcc ccgccaggca gaggcaagat ggggtggggg 4989 cggcacctgc caattatgcc aaagtcttgg agtggcagct ggcaccatca ccaaggcaca 5049 aatgccagca gagacctggc actcacctgg gttgtgattc catagggccc ctgtctcctg 5109 ttggtctccc aggctcaaag gctgacctga taattcaagt gaaggatgcc tagttcaagg 5169 cctcccagtt cctcatccca ggccacctgg tcaggtggtc ccaagggaca agctaggtcc 5229 tcctgaactg cagaggctgc caataaactg gcaacacagg tgttgcagga agatatagct 5289 gggtcctcat cctgggtctg taatttatta gacgtgtggc tttggacaaa tgacataatt 5349 tcccagagcc tccttagata aaaaactagg gctttgctta ccttggcgta ttgttaggaa 5409 aattaaatga gttgctcaat 5429 <210> 35 <211> 5275 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1827) .. (4259) <400> 35 tttactttgt ctctatgttt ctgtttcttt ctctgtaagt aagagtgggg agactagagc 60 tacctatctc aggattgtgt ggagtaaatg aataatgtgt gtaaaacatt taaaatagtg 120 tctcatgtac actaagtgct taataaatgc taataatagg aatagtaaca acagtatagt 180 tacattgtta ttataaatct gtatctgtgg tactcttagc ttaagttcgt acaaaaatat 240 tgagctgcct gttagaaatc tacatttgga tgcctcccca gaacatcctg tgcccgacgg 300 gacaatccca gagcctcctc tcgcaacaga accatccagc gagacaaccc cagaacatcc 360 tgtgcccagc gggacaatcc cagagcctcc tctcctaaca gaaccatcca acaagagaac 420 ctcagaacat cctgtacccg acaggacaat cccaggacct cctctcccaa tagagccaca 480 cgagacaacc ccagaacatc ctgtgcccag cgggacaatc tcagagcctc ctctcccatc 540 agagccaccc aacaggacaa ccccagaact tgtattcaac agaacatccc cagatcatct 600 tctacccaac aagacaaccc taaaacctct tgtaccaaac gagataacct cagacccact 660 tgtacacagc gggaccgcac acagtccttt tcctttcaac gagacaaccc tggaacctcc 720 tcatctcaat gctgcaccca aaaggagaat ctgagaccat catctcccca ccgctccact 780 caatggaaca atcccaggaa ttcatctccc catcgtacta acaaagacat cccctgggcc 840 tcgtttcccc tccggccaac tcagagtgat ggtccccgaa cctcttcccc atctcgctcc 900 aagcaaagcg aggttccctg ggcatccatc gccctccggc caacccaagg tgacaggcct 960 cagacatcct ctcccagcag gccagcccag catgacccac cccagtcctc ctttggcccc 1020 acccagtaca acttgccatc ccgggccacc tcttcctccc ataacccagg ccaccagagc 1080 acctcccgaa cttcctcacc tgtgtacccc gctgcctatg gggctcccct gacctctcct 1140 gagccctccc agcctccatg tgctgtgtgc attgggcacc gggatgcccc tcgagcctct 1200 tcgccccctc gctatttgca gcacgacccc ttccccttct tcccagagcc ccgcgcccct 1260 gagagtgaac cgccccacca cgagcctccc tatataccac ctgctgtgtg cattggacac 1320 cgagatgccc cccgggcgtc ctcgcccccc cgccacaccc aatttgaccc cttccccttc 1380 ctcccagaca catcagatgc cgagcatcag tgtcagtccc cccaacacga gccccttcag 1440 ctccctgcac ctgtgtgtat tgggtaccga gatgcacccc gggcctcctc cccaccacgc 1500 caggccccag agccttccct cttattccag gacctcccca gggccagcac agagagcctt 1560 gtcccttcca tggactctct gcacgagtgc ccccacatcc ccacccctgt gtgcattggg 1620 caccgggatg caccctcctt ctcatcccca ccacgccagg ctcctgagcc atccctcttc 1680 ttccaggatc cccctgg aac tagtatggag agcctggccc cctccactga ctctctgcat 1740 ggctccccag tgctgatccc ccaagtgtgc atcgggcacc gggatgcacc ccgagcctcc 1800 tccccacccc gccacccacc cagtga cct agc gtt cg gg c ct gc acc gcc acc ct gc acc ct gc acc ct gc acc ct gc acc ct gc acc ct gc acc ct gg cgg gga gac 1901 Thr Gly Gln Leu Trp Gly Leu Pro Gly Leu Ser Ala Ser Arg Gly Asp 10 15 20 25 cag gca caa ctt gga gcg gga gga gta cac tgt gct ggc cga cct gcc 1949 Gln Ala Gln Leu Gly Ala Gly Gly Val His Cys Ala Gly Arg Pro Ala 30 35 40 ccc acc cag gag gct ggc cca gag aca gcc agg gcc cca ggc gca gtg 1997 Pro Thr Gln Glu Ala Gly Pro Glu Thr Ala Arg Ala Pro Gly Ala Val 45 50 55 cag cag cgg ggg ccg cac cca cag ccc tgg ccg tgc aga ggt gga gcg 2045 Gln Gln Arg Gly Pro His Pro Gln Pro Trp Pro Cys Arg Gly Gly Ala 60 65 70 cct ctt cgg gca aga gcg cag gtg acc atg ctc cct gcc aaa cag gca 2093 Pro Leu Arg Ala Arg Ala Gln Val Thr Met Leu Pro Ala Lys Gln Ala 75 80 85 gaa ctg acc cgg cgg agc caa gca gag ccc cct cat cct c gg agt cct 2141 Glu Leu Thr Arg Arg Ser Gln Ala Glu Pro Pro His Pro Arg Ser Pro 90 95 100 105 gag aag aga cct gag gga gat cgg cag ctc cag ggg tcc ccg ctg ccc 2189 Glu Lys Arg Pro Glu Gly Asp Arg Gln Leu Gln Gly Ser Pro Leu Pro 110 115 120 ccc agg aca tca gcc agg acc cct gag agg gag ctg cgg aca cag aga 2237 Pro Arg Thr Ser Ala Arg Thr Pro Glu Arg Glu Leu Arg Thr Gln Arg 125 130 135 cct ctg gag agt ggc caa gca ggc cca aga cag cct ctg ggg gtg tgg 2285 Pro Leu Glu Ser Gly Gln Ala Gly Pro Arg Gln Pro Leu Gly Val Trp 140 145 150 cag agt cag gag gaa ccg cca ggg tcc cag ggc cct cat aga cac cta 2333 Ser Gln Glu Glu Pro Pro Gly Ser Gln Gly Pro His Arg His Leu 155 160 165 gaa agg agc tgg agc agc cag gag gga ggc ctg ggc cct ggg ggc tgg 2381 Glu Arg Ser Trp Ser Ser Gln Glu Gly Gly Leu Gly Pro Gly Gly Trp 170 175 180 185 tgg gga tgt gga gag ccc agc ctg ggg gca gcc aaa gcc ccg gag gga 2429 Trp Gly Cys Gly Glu Pro Ser Leu Gly Ala Ala Lys Ala Pro Glu Gly 190 195 200 gca tgg ggg ggc act tcc agg gag tac aag gag agc tgg ggg cag cca 2477 Ala Trp Gly Gly Thr Ser Arg Glu Tyr Lys Glu Ser Trp Gly Gln Pro 205 210 215 gag gcc tgg gag gag aag ccc act cat gag ctc ccc aga gaa cta gga 2525 Glu Ala Trp Glu Glu Lys Pro Thr His Glu Leu Pro Arg Glu Leu Gly 220 225 230 aag aga agc cca ctc acg agc ccc cct gag aac tgg gga ggc ccc gca 2573 Lys Arg Ser Pro Leu Thr Ser Pro Pro Glu Asn Trp Gly Gly Pro Ala 235 240 245 gag tcc tca caa tcc tgg cac tct ggg aca ccc act gct gtg ggc tgg 2621 Glu Ser Ser Gln Ser Trp His Ser Gly Thr Pro Thr Ala Val Gly Trp 250 255 260 265 ggg gca gag gga gcg tgt cca tac ccg cgt ggc tct gag agg cga ccc 2669 Gly Ala Glu Gly Ala Cys Pro Tyr Pro Arg Gly Ser Glu Arg Arg Pro 270 275 280 gag ctt gac tgg agg gat ctg ctt ggc ctt ctc cgg gca cca gga gag 2717 Glu Leu Asp Trp Arg Asp Leu Leu Gly Leu Arg Ala Pro Gly Glu 285 290 295 295 ggg gtc tgg gcc cgt gtc ccc agc ctg gac tgg gag ggc ctc ttg gag 2765 Gly Val Trp Ala Arg Val Pro Ser Leu Asp Trp Glu Gly Leu Leu Glu 300 305 310 ctc ctg ca gcc agg ctg ccc cgc aag gac cca gct gga cac agg gat 2813 Leu Leu Gln Ala Arg Leu Pro Arg Lys Asp Pro Ala Gly His Arg Asp 315 320 325 gac ctg gcc agg gct tta ggg cca gag ctg ggt ccc cca ggc aca Asp Leu Ala Arg Ala Leu Gly Pro Glu Leu Gly Pro Pro Gly Thr Asn 330 335 340 345 gat gtc cct gag cag gag tca cac agc cag cca gaa ggc tgg gcc gag 2909 Asp Val Pro Glu Gln Glu Ser His Ser Gln Pro Glu Gly Trp Ala Glu 350 355 360 gcc acc cca gtc aat gga cac agc ccc gca ctg cag tcc cag agc ccg 2957 Ala Thr Pro Val Asn Gly His Ser Pro Ala Leu Gln Ser Gln Ser Pro 365 370 375 375 gtc cag ctg ccc agc cct gcc tgc acc tcc acc cag tgg cca aag atc 3005 Val Gln Leu Pro Ser Pro Ala Cys Thr Ser Thr Gln Trp Pro Lys Ile 380 385 390 aaa gtg aca aga gga cca gcg acc gca act ctg gca ggc ctg gag cag 3053 Lys Val Thr Arg Gly Pro Ala Thr Ala Thr Leu Ala Gly Leu Glu Gln 395 400 405 acg ggc ccc ctg ggg agc agg agc act gcg aag ggc ccc agc ttg cca 3101 Thr Gly Pro Leu Gly Ser Arg Ser Thr Ala Lys Gly Pro Ser Leu Pro 410 415 420 425 gag ctg cag ttc caa cca gag gag cct gag gag tca gaa cca agc aga 3149 Glu Leu Gln Phe Gln Pro Glu Glu Pro Glu Glu Ser Glu Pro Ser Arg 430 435 440 440 ggc caa gac ccc ctg act gac cag aag cag gac tcg ccc gat ctg 3197 Gly Gln Asp Pro Leu Thr Asp Gln Lys Gln Ala Asp Ser Pro Asp Leu 445 450 455 ctc aac ttc aag aag gga tgg atg tcg atc ttg gac gag cct gga gag 3245 Leu Asn Phe Lys Met Gly Ser Ile Leu Asp Glu Pro Gly Glu 460 465 470 cct ccc tcc ccc tcg ctc acc acc acc tct act tcg cag tgg aag aaa 3293 Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln Trp Lys Lys 475 480 485 cat tgg ttt gtg ctg aca gat tca agt ctc aaa tat tac aga gac tcc 3341 His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr Arg Asp Ser 490 495 500 505 act gct gag gag gca gat gag ctg gat ggt gag atc gac ctg cgt tcc 3389 Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp Leu Arg Ser 510 515 520 tgc acg gat gtc act gag tac gcg gtg cag cgc aac tat ggc ttc cag 3437 Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Ag sn Tyr Gly Phe Gln 525 530 535 atc cac acc aag gat gct gtc tat acc ttg tcg gcc atg acc tca ggc 3485 Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met Thr Ser Gly 540 545 550 atc cgg cgg aac tgg atc gag gct ctg aga aag acc gta cgt cca act 3533 Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val Arg Pro Thr 555 560 565 tca gcc cca gat gtc acc aag ctc tcg gac tct aac aag gag aac gcg 3581 Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys Glu Asn Ala 570 575 580 585 ctg cac agc tac agc acc cag aag ggc ccc ctg aag gca ggg gag cag 3629 Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala Gly Glu Gln 590 595 600 cgg gcg ggc tct gag gtc atc agc cgg ggt ggc cct cgg aag gcg gac 3677 Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg Lys Ala Asp 605 610 615 ggg cag cgt cag gcc ttg gac tac gt tcg ccg ctg acc cag 3725 Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro Leu Thr Gln 620 625 630 gct tcc ccg cag cgg gcc cgc acc cca gcc cgc act cct gac cgc ctg 3773 Ala Ser Pro Gln Arg Ala A rg Thr Pro Ala Arg Thr Pro Asp Arg Leu 635 640 645 gcc aag cag gag gag ctg gag cgg gac ctg gcc cag cgc tcc gag gag 3821 Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg Ser Glu Glu 650 665 660 cgg cgc aag tgg ttt gag gcc aca gac agc agg acc cca gag gtg cct 3869 Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro Glu Val Pro 670 675 680 gct ggt gag ggg ccg cgc cgg ggc ctg ggt gcc ccc gag gac 3917 Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu Thr Glu Asp 685 690 695 cag caa aac cgg ctt agt gag gag atc gag aag aag tgg cag gag ctg 3965 Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp Gln Glu Leu 700 705 710 gag aag ctg ccc ctg cgg gag aat aag cgg gtg ccc ctc act gcc ctg 4013 Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu Thr Ala Leu 715 720 725 ctc aac gacc gag cgc cga ggg ccc cca agt gac ggc cac 4061 Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser Asp Gly His 730 735 740 745 gag gca ctg gag aag gag gtt cag gct ctt cgg gcc cag ctg gag gcg 4109 Ggl u Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln Leu Glu Ala 750 755 760 tgg cgt ctc caa ggg gag gct cct cag agt gca ctg aga tcc cag gag 4157 Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg Ser Gln Glu 765 770 775 gat ggc cac atc ccc ccg ggc tac atc tca cag gta agg ccg ggg ggc 4205 Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Val Arg Pro Gly Gly 780 785 790 tgt ttt tca ggg gga ggg ggc gg ctg gtt gcc gtg tta tca gga 4253 Cys Phe Ser Gly Gly Gly Gly Arg Phe Leu Val Ala Val Leu Ser Gly 795 800 805 aac agc tgagattttg ggagcccttc ctgtgtgtgc tggaacctgt gtggggcatt 4309 Asn Ser 810 tgacatgcgt catctcattt actctcccca cagctggtgg gcgtgatcac tgtgcccgtt 4369 ttacagacaa ggccactgag ctctgagagg ttatgtgact tgcccaaggt caccccgcct 4429 gcaggtctca aaggtgggat ttgagcgagg gtccggctga ctgcagagcc tgtgtgtgag 4489 tccccgtgtg acactctgca cttggaccct tgccccgggg aagtgggggg ctagtggccc 4549 cgagagtcac tccctgaaca cagggaaatc ctgccgaggc ccactgggcc aaggccccac 4609 acaaggaggt ctgcaggaca ggggagcccc cagtagccct cagagaatgc accgtccgcc 4669 taggacagcg gttctcaacg gggtccattt tgtccccctt ggggacattt ggctgtgtct 4729 gggaatactt ctggttgtca caactaggac aaactaactc tctagaaaaa acgtgtgtgt 4789 gtacacatat ataagtttat tataaatttt accaataaaa acaatgctta gtacacaatt 4849 tacaaataaa aatatataat tttattgtga attccgtaca gcaaatggat ttttctcaga 4909 atgctttcag tgattttttc catactcttg tatccacaac tgattaacaa agggggttgt 4969 tctaacatgt gtgctggttg acatttttgt ttatggtaat gagtaagatg agaagacatt 5029 tgtcgaaact ttactggtcc atgttgtcag ctacttcttt gctagatcgg atagtagttt 5089 tctattgaga atatatgaga atattctatt aagaatattt ttgcaatttt ttgttctatt 5149 tacaatgtaa tggttataga tgtgagatac ttctaagttt aatctgcatt attagcattt 5209 tcttatcact tgcttaagtc tagacaatca acaaaacaat aaatcaagcc 5 gtg atg <210> 36 <211> 4973 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (646) <400> 36 g ccc agc cgg aca ctg cgc cag gcc agc cac gag tcc att gag gac agc 49 Pro Ser Arg Thr Leu Arg Gln Ala Ser His Glu Ser Ile Glu Asp Ser 1 5 10 15 atg aac agc tat ggc tca gag ggc aac ctt aac tat gga gga gtt tgc 97 Met Asn Ser Tyr Gly Ser Glu Gly Asn Leu Asn Tyr Gly Gly Val Cys 20 25 30 ctg gcg tcg gac gcc cag ttc agt gac ttc ctg gga agc atg ggg ccg 145 Leu Ala Ser Gln Phe Ser Asp Phe Leu Gly Ser Met Gly Pro 35 40 45 gca cag ttt gtg ggc cgc cag acc ctg gcc acc aca ccc atg ggg gat 193 Ala Gln Phe Val Gly Arg Gln Thr Leu Ala Thr Thr Pro Met Gly Asp 50 55 60 gtg gag atc ggt ctg cag gag cgg aac ggt cag ttg gag gtg gac att 241 Val Glu Ile Gly Leu Gln Glu Arg Asn Gly Gln Leu Glu Val Asp Ile 65 70 75 80 atc cag gct cgg gga ctg aca gcc aag cca ggc tcc aca ctg cca 289 Ile Gln Ala Arg Gly Leu Thr Ala Lys Pro Gly Ser Lys Thr Leu Pro 85 90 95 gcg gcc tac atc aag gcc tac ctg cta gag aat ggc atc tgc att gcc 337 Ala Ala Tyr Ile Lys Ala Tyr Leu Leu Glu Asn Gly Ile Cys Ile Ala 100 105 1 10 aag aag aag acc aaa gtc gct cgc aag tcg ctg gac cca ctg tat aac 385 Lys Lys Lys Thr Lys Val Ala Arg Lys Ser Leu Asp Pro Leu Tyr Asn 115 120 125 cag gtg ctg ctg ttt cct gag agt ccc cag ggc aaa ctc cag gtg 433 Gln Val Leu Leu Phe Pro Glu Ser Pro Gln Gly Lys Val Leu Gln Val 130 135 140 atc gtg tgg ggg aac tac ggg cgg atg gag cgg aag cag ttc atg ggt 481 Ile Val Trp Gly Asn Tyr Gly Arg Met Glu Arg Lys Gln Phe Met Gly 145 150 155 160 gtg gct cgc gtg ctg ctg gag gag ctg gac ttg acc acc ctg gcc gtg 529 Val Ala Arg Val Leu Leu Glu Glu Leu Asp Leu Thr Thr Leu Ala Val 165 170 175 ggc tgg tac ctc ttc ccc acc tcc tcc atg gtg gac cca gcc aca 577 Gly Trp Tyr Lys Leu Phe Pro Thr Ser Ser Met Val Asp Pro Ala Thr 180 185 190 ggc ccc ctg ctc cgg cag gca tcc cag ttg tcc ctc gag agc acc gtg 625 Pro Leu Leu Arg Gln Ala Ser Gln Leu Ser Leu Glu Ser Thr Val 195 200 205 ggg ccc tgc gga gaa cga tct tagtgctgga atggggaggg gctccccaag 676 Gly Pro Cys Gly Glu Arg Ser 210 215 atggcctgga gaccacccag ccctg acctg ggaccccagg cccaggggca cattgaacag 736 gaggacgggg ctctccccca cagtggggaa gcagaacggg gagacctgcc cccccttggg 796 cccctcctca ccccttcttt gcctcctacc cccgagacct cccctctccc aacgggattg 856 gctacacttt tgacttggcc ggttcttgac ctggtggatg tggctgcagt ccagagaaag 916 gaaagattga ggtggcagag cagaccactc tcccttccca aactgtccaa cttctccccc 976 tttttgcctc ctcggaagct cgctgcccag agccatgtcc agaacccagc cggccatctc 1036 catggtgcca attaccagca agtgtctttc ctgcggcacc gggttcaggc agctactcct 1096 gccccagaga tgaaggggca gctttgcaag gatccggagc cagctcccag gggcccagag 1156 ccccccactt gaagaggagc ttgagcttcc ctctgcctgc ccgtggaagg agctttgccg 1216 cagcctgtcc gagtccatcc gtccgtcccc tcctgcctgc ccctcttctg gtggctctag 1276 gaattggggt tcagcaggga ccaaaggaaa ggaggaggtg ccgggggcct ggcacagacc 1336 cctaggtgcc tcgctccatg ggattgcaac aagctagttt aggaaccgct ggcggactag 1396 aaagaatgtt gtcgtctgtg ttccggtgga ggagctgtgg aacctgagtt tccagaaccc 1456 caaccctaga gagcatttgg gggtgctgta ttggaggggg aggctaagga aagttgggat 1516 tgggactggt ggtgccaaga taagggtttc tcaaa ttgga gaacccctcc ttgttgcatg 1576 aggtcaatgg tcatcttgtc tacccaccct gcctccaggc cagggggctg gggaggcaaa 1636 tagagccccc ctattttagt ctttttaaaa aaaacatcct atactaaggg cagaacccac 1696 tgccccggcc tcaattacct tggctgaagg aaagatggcg gtaggagaga aaagtgaaga 1756 ggcgtgagtg taagaactgg gagattcctt ttccagcagg cctgggtagc tgccttccca 1816 gcccagccct ccctggggcc tgcgggagcc cttttgcatg caagggagga tggaggctgg 1876 cccctcttta tagaagcaca tttctgccac ctcccctggg aggcacccag aagcctgcca 1936 ctctttacct agtccctgct gtgtagggcg tagtccaggt tagctaggta gagttagtgc 1996 tccaagccct ggggcctgtt cttagctcat gcatagtcct tacagagtcc caggaccggg 2056 ggtggagagg agcctcaagt acattccagg agaccactgt ctcctcgctg gcctgggcct 2116 agatggggca gcctggctca caggaggcca gcccctcctc ctccgccccc ttccttccct 2176 tgtccccgta gggttatagc tggagctgcc tgttatactc ggctgttctg atttattatt 2236 cttggtactg actttcttta tgagggactc ctaagggttg taggaccttg gcagaggggg 2296 cctggtctcc attagagggt gttgttttct cctgaggaca cccaggctgc ctttggtccc 2356 accctgttcc tggtcccggt cccggtccca gtcccaccag gcaactcctt ccacccggaa 2416 attcttccct tcccttagcc tgtggaaacc ctgggtattc tttaaagttc tggtcaatgt 2476 atatcacctc cacagagctg cttaccctgc actgggaagg ggagatggag acgccccctt 2536 tacccaggag gtcttcagag tttcctggga ccgcggtggg tggaatccca aggctggggg 2596 tggaaggagc agggctctgg agggattcgc attcaaggca cagaattggc cccttgcctg 2656 tttgtttttc taaccagtgt gatttctctg ctgttcgttt attacttacc attggaatat 2716 tttgagccag gagagcgcct tctctctcca gccatcaccg ctgtggttgt tcaggggtag 2776 cttttcaaaa acagggcaga gcctggctgt cccaaccagg gggagcaggg gcttggccct 2836 gacagcctga gcccttcccc tggtgtctgc acagccttta taaagagaga gagagctccg 2896 aagcaataac aacacctggg ggtggtcagt gagggccccc tcaatgattt tcttgtttgt 2956 tctgtgaaat cccgctcacc tcctggaggg gtggagcagc tgggggctgg agccctgttt 3016 ctttgtgtca tcgtgagcat gtgccccttc ccaggggctg tgaccattgg gtgtgggaac 3076 tacggtctgt cctcaccaag ggatgggggt ttggggagga gagtgacatt ttcatcatta 3136 gcttcggaga agcttcaagc ccatcctgtc cccgctactg cctggcccct tgctgactca 3196 ggctgcactg tttgaagagg agcagagagg ctggcactag gggcc actgg ggggctgggg 3256 tctccagggg atgactgttt tcaatctctg ggccaagatc acatgcagga taccacggga 3316 aggagccatc tccactctcc ttctccagaa cccccttgaa gggcctttgg gaccattagt 3376 ccatttccat tttacagaca aggaaatcaa gacccagctt gggggaaaag ccacccctgg 3436 agtcacctgt gtgttcagtg gcacccccag cctgggtccc ctcctcccaa tagaggctga 3496 gccggagcca gggcagtatg aggtggggct gccactgccc atacctcctc ctcccttctt 3556 tctttgaagc ctaatggccc cccaaaagat gggcaggaca agctgtagcc catctgagag 3616 gttgggaaac tgaggcccag aaacaggaag tgactcacac aagacccctc agcaagggtg 3676 caaaggggga agaactaggg gctccattgt tcttcaggcg acaggagacc gttgctccag 3736 tgcatgtctg ctgggacaag gattcctggc ctcgaagccc tgggctgcac agccctactg 3796 ggctccacct ctataaacca gtgacttctc tgggcctggg tctgggggag agggttgcca 3856 gggagactca gctctccttg ggggctggcc cagctgactg agggtacaca ggattgggtc 3916 tagaccttga tgcctgggtg gagggccctt gtaaggggcc atagcctctt caggaccaac 3976 tggagggaga gttaggaaac accagctcct gcctggggca gtgagggaat gggagcagct 4036 gtgggcgcct catttcaggc aagtcctccc caaaccttca gatgcagtga gacctggcct 4096 tcctgttgtg cttttcagac tttgttttca gaatgctttt atctcgagtg tgcccttcgg 4156 ccctcacaag agcccctggg gagtaggtgg tggcctgtgc cgtcatcccc atttcaaagc 4216 agggagctga ggtcctggga ggggaaagtg cttgcctgag gtcccactgt gttagtgggt 4276 gggcaggact ggaactcggt tctccaacag cccagagctc actcttttac acccagaggt 4336 ggagcaggtg gcttaggggg tggttatgta cttcacaagc caattccctt cagccaggag 4396 ctcctgggtg catttccgtg tcagaaacag taccgagtcc caccccctct ggaggcacag 4456 ctgttgcgtc aggcaaggtc acctgcattt atttattgag cagcagtgct gtgtcaggcc 4516 cagggaccga gcccctctcc ctgttcccct atggtgtctc cgaggccctc tgggagggcc 4576 ccacatctgg agcagcacct cagagtggac agaaagcatt agcgtccacg agctcacccg 4636 acgccgagcc tgtgaggtgg gctgatggtg cccgtctaac ccagcgcttc agggaggtca 4696 gaatggagcc gaacccaggg ctgtgagcat cacctctgga gccctttcac tttatgactg 4756 cttcctggac gggtggtggg aaggcaggag cctgggtcct taggctgggg gcctctctcc 4816 atccacccac ctttccctca ttccctctct tggagcagca gccgcccagg cctttaggga 4876 gggagggttt ctggggccct tgggttggag tggggtcgcg ttgcattgtg ttca tgacca 4936 tgtagctcat gttgaaatta aagtttttgg cttttct 4973 <210> 37 <211> 5223 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (3402) <400> 37 cgc ctg gca ctc tca ccc gaa gac aag ccc atc cgc ttg tcc ccc tcc 48 Arg Leu Ala Leu Ser Pro Glu Asp Lys Pro Ile Arg Leu Ser Pro Ser 1 5 10 15 aag atc aca gag ccg ctg cgg gag ggc ccg gag gaa gaa ccg ctg gct 96 Lys Ile Thr Glu Pro Leu Arg Glu Gly Pro Glu Glu Glu Pro Leu Ala 20 25 30 gag cgg gag gtg aag gca gag gtg gag gac atg gac gag ggc ccc aca 144 Glu Arg Glu Val Lys Glu Val Glu Asp Met Asp Glu Gly Pro Thr 35 40 45 gag ctg ccg cct ctg gag tcg ccg ctg cca ctg ccc gcc gcg gaa gcc 192 Glu Leu Pro Pro Leu Glu Ser Pro Leu Pro Leu Pro Ala Ala Glu Ala 50 55 60 atg gct acc ccc agc cct gca ggg ggt tgt gga ggt ggc ctg ttg gag 240 Met Ala Thr Pro Ser Pro Ala Gly Gly Cys Gly Gly Gly Leu Leu Glu 65 70 75 80 gcc cag gcg ctg agt gcc acc ggg cag agc tgc gca gag ccc tct gag 288 Ala Gln Ala Leu Ser Ala Thr Gly Gln Ser Cys Ala Glu Pro Ser Glu 85 90 95 tgt cca gac ttt gtg gag ggg cct gaa cca cgg gtg gat tcc ccg ggc 336 Cys Pro Asp Phe Val Glu Gly Pro Glu Pro Arg Val Asp Ser Pro Gly 100 105 110 cgg aca gaa ccc tgc acc gcc gcc ctg gac ctg ggg gtg cag ctg aca 384 Arg Thr Glu Pro Cys Thr Ala Ala Leu Asp Leu Gly Val Gln Leu Thr 115 120 125 ccc gag aca ctg gtg gag gcc aag gag gag ccg gtg gg cct gtg 432 Pro Glu Thr Leu Val Glu Ala Lys Glu Glu Pro Val Glu Val Pro Val 130 135 140 ggg gtg ccc gtg gtg gag gca gtg ccc gag gaa ggc ctg gcg cag gtg 480 Gly Val Pro Val Val Glu Ala Val Pro Glu Glu Gly Leu Ala Gln Val 145 150 155 160 gca ccg agc gag tcc cag ccc acc cta gaa atg tca gac tgt gac gtg 528 Ala Pro Ser Glu Ser Gln Pro Thr Leu Glu Met Ser Asp Cys Asp Val 165 170 175 ccc gcc ggg gag gga cag tgc ccg agc ctg gag ccc caa gag gcc gtg 576 Pro Ala Gly Glu Gly Gln Cys Pro Ser Leu Glu Pro Gln Glu Ala Val 180 185 190 cct gta ctc ggc agc acc tgc ttc ctg gaa gag gca agc tct gac cag Leu Gly Ser Thr Cys Phe Leu Glu Glu Ala Ser Ser Asp Gln 195 200 205 ttc ctg ccc agt ctg gag gac cca ctg gct ggc atg aac gcc ctg gcg 672 Phe Leu Pro Ser Leu Glu Asp Pro Leu Ala Gly Met Asn Ala Leu Al a 210 215 220 gca gct gcg gag ctg ccc cag gcc agg cct ctg ccc tcc ccg ggt gct 720 Ala Ala Ala Glu Leu Pro Gln Ala Arg Pro Leu Pro Ser Pro Gly Ala 225 230 235 240 gct gga gcc cag gcc ttg gag aag ctg gaa gca gcc gag agc ctt gtc 768 Ala Gly Ala Gln Ala Leu Glu Lys Leu Glu Ala Ala Glu Ser Leu Val 245 250 255 ttg gag cag agc ttc ctg cat ggc atc acc ctg cta agt gag atc gca 816 Leu Glu Ser His Gly Ile Thr Leu Leu Ser Glu Ile Ala 260 265 270 gag ctg gag ctg gag agg agg agc caa gag atg gga ggt gcg gag cgg 864 Glu Leu Glu Leu Glu Arg Arg Ser Gln Glu Met Gly Gly Ala Glu Arg 275 280 g ctg gtg gcg cgg ccc tcc ctg gag agt ctg ctg gca gct ggc agc 912 Ala Leu Val Ala Arg Pro Ser Leu Glu Ser Leu Leu Ala Ala Gly Ser 290 295 300 cac atg ctg agg gag gtg ctg gat ggg cccgt aag 960 His Met Leu Arg Glu Val Leu Asp Gly Pro Val Val Asp Pro Leu Lys 305 310 315 320 aac ctg cgg ctc ccg cgg gag ctg aag ccc aac aag aag tac agc tgg 1008 Asn Leu Arg Leu Pro Arg Glu Leu Lys Pro AsnLys Lys Tyr Ser Trp 325 330 335 atg cgc aag aag gag gag cgg atg tat gcc atg aag tcc tcc ctg gag 1056 Met Arg Lys Lys Glu Glu Glu Arg Met Tyr Ala Met Lys Ser Ser Leu Glu 340 345 350 350 gac atg gac gcc ctg ctg gac ttc cgg atg cgg ctg gcc gag gtg 1104 Asp Met Asp Ala Leu Glu Leu Asp Phe Arg Met Arg Leu Ala Glu Val 355 360 365 cag cgc cag tac aag gag aag cag cgt gag ctg gtg ag Gcggcgggcggcagggcggggcag Tyr Lys Glu Lys Gln Arg Glu Leu Val Lys Leu Gln Arg 370 375 380 cgc cgg gac tcc gag gac agg cgc gag gaa ccc cat aga agc ttg gca 1200 Arg Arg Asp Ser Glu Asp Arg Arg Glu Glu Pro His Arg Ser Leu Ala 385 390 395 400 cgc aga ggc cct ggc agg ccg cgg aaa cgg acc cac gcc ccg agc gcc 1248 Arg Arg Gly Pro Gly Arg Pro Arg Lys Arg Thr His Ala Pro Ser Ala 405 410 415 ctg tcg ccc ccc cgc aag aga ggg ag ag cac agt agc gga aag 1296 Leu Ser Pro Pro Arg Lys Arg Gly Lys Ser Gly His Ser Ser Gly Lys 420 425 430 ctg agc agc aag tct ctg ctg aca tca gat gat tat gag ctg gga gca 1344 Leu Ser Ser Lys Ser Leu L eu Thr Ser Asp Asp Tyr Glu Leu Gly Ala 435 440 445 ggg ata aga aag aga cac aag ggg tct gag gag gaa cat gat gcc ctc 1392 Gly Ile Arg Lys Arg His Lys Gly Ser Glu Glu Glu His Asp Ala Leu 450 455 460 atc gga atg ggg aaa gcc agg ggg agg aac cag act tgg gat gaa cat 1440 Ile Gly Met Gly Lys Ala Arg Gly Arg Asn Gln Thr Trp Asp Glu His 465 470 475 475 480 gag gcc tcg tcg gac ttc atc agt cag cta aag attag aag aag 1488 Glu Ala Ser Ser Asp Phe Ile Ser Gln Leu Lys Ile Lys Lys Lys Lys 485 490 495 atg gcc agc gac cag gag cag ttg gca agc aag ctc gac aag gcc ctc 1536 Met Ala Ser Asp Gln Glu Gln Leu Ala Ser Leu Asp Lys Ala Leu 500 505 510 tcc ctc acc aag cag gac aag ttg aag tcg ccc ttc aag ttt tcg gac 1584 Ser Leu Thr Lys Gln Asp Lys Leu Lys Ser Pro Phe Lys Phe Ser Asp 515 520 525 agt gct ggg ggg aaa t aaa act agc ggg ggc tgc ggc agg tac ttg 1632 Ser Ala Gly Gly Lys Ser Lys Thr Ser Gly Gly Cys Gly Arg Tyr Leu 530 535 540 act cct tac gac agc ctg ctg ggg aag aac agg aag gcg ctg gcc aag 1680 ro Tyr Asp Ser Leu Leu Gly Lys Asn Arg Lys Ala Leu Ala Lys 545 550 555 560 ggc ctc ggc ctg tct ctg aaa tcc tcc aga gaa ggt aaa cac aaa agg 1728 Gly Leu Gly Leu Ser Leu Lys Ser Ser Arg Glu Gly Lys Arg 565 570 575 gca gcc aaa acc agg aag atg gag gtg ggg ttc aag gcc aga ggc cag 1776 Ala Ala Lys Thr Arg Lys Met Glu Val Gly Phe Lys Ala Arg Gly Gln 580 585 590 ccc aag tcg gcc cat tcc ccg tcg gaa gtg agc agc tac tct 1824 Pro Lys Ser Ala His Ser Pro Phe Ala Ser Glu Val Ser Ser Tyr Ser 595 600 605 tac aat acg gac tca gag gaa gac gaa gaa ttc ctg aag gac gag tgg 1872 Tyr Asn Thr Asp Ser Glu Glu Asp Glu Glu Phe Leu Lys Asp Glu Trp 610 615 620 ccc gcc caa ggc ccc tcc agc tcc aaa ctg acg cct tcc ctc ctg tgt 1920 Pro Ala Gln Gly Pro Ser Ser Ser Lys Leu Thr Pro Ser Leu Leu Cys 625 630 635 640 agc atg gtg gca aag aac agc aag gca gct ggt ggc ccc aag ctg acc 1968 Ser Met Val Ala Lys Asn Ser Lys Ala Ala Gly Gly Pro Lys Leu Thr 645 650 655 aag agg ggc ctg gcg gcc ccc cgg act ctg aaa ccc ccg gcc acc 2016 Lys Arg Gly Leu Ala Ala Pro Arg Thr Leu Lys Pro Lys Pro Ala Thr 660 665 670 agc agg aag cag ccg ttt tgt ctg ctg ctt cga gag gcc gag gcg cgt 2064 Ser Arg Lys Gln Pro Phe Cys Leu Leu Leu Arg Glu Ala Glu Ala Arg 675 680 685 tcc tcc ttc agc gac tct tcg gag gaa tcg ttt gac caa gat gag agc 2112 Ser Ser Phe Ser Asp Ser Ser Glu Glu Ser Phe Asp Gln Asp Glu Ser 690 695 700 tcg gag gag gag gag gag gag gag ctc gag gag gag gac gag gcc 2160 Ser Glu Glu Glu Asp Glu Glu Glu Glu Leu Glu Glu Glu Asp Glu Ala 705 710 715 720 agc ggt ggt ggc tac agg ctg ggt gcc cgg gag cgg gcc ctgca Serca Gly Gly Gly Tyr Arg Leu Gly Ala Arg Glu Arg Ala Leu Ser Pro 725 730 735 ggc ctg gag gag agt ggg ctg ggc ctg ctg gca cgc ttc gcc gcc agc 2256 Gly Leu Glu Glu Ser Gly Leu Aly Arg Ala Ser 740 745 750 gcc ctc ccc agc ccc acg gtg ggt cca tcc ctg tct gtg gta cag ctg 2304 Ala Leu Pro Ser Pro Thr Val Gly Pro Ser Leu Ser Val Val Gln Leu 755 760 765 gag gcc aag cag aag gcc cgg aag aaa gag gag cgg cag agc ctg ctg 2352 Glu Ala Lys Gln Lys Ala Arg Lys Lys Glu Glu Arg Gln Ser Leu Leu 770 775 780 ggc aca gag ttc gag tac acc gac tca gag agc gag gtc aag gtg Gglu Ghe G400 Ghe Tyr Thr Asp Ser Glu Ser Glu Val Lys Val Arg 785 790 795 800 aag cgg tcg cct gcg ggg ctg ctg cgg ccc aag aag ggg ctg ggg gag 2448 Lys Arg Ser Pro Ala Gly Leu Leu Arg Pro Lys Lys Gly Leu Gly Glu 805 810 815 ccg gga ccc tcc ctg gcc gca ccc acg cct ggc gcc cgc ggt ccc gac 2496 Pro Gly Pro Ser Leu Ala Ala Pro Thr Pro Gly Ala Arg Gly Pro Asp 820 825 830 ccc agc agc cca gac aag gcc aag ctg gag ggt ggg cgc aag 2544 Pro Ser Ser Pro Asp Lys Ala Lys Leu Ala Val Glu Lys Gly Arg Lys 835 840 845 gcc cgg aag ctg cgg ggc ccc aag gag cct ggc ttc gag gcg ggg ccc 2592 Ala Arg Lys Leu Arg Gly Pro Lys Glu Gly Phe Glu Ala Gly Pro 850 855 860 gag gcc agc gac gac gac ctg tgg acg cgg cgc cgc agc gag cgc atc 2640 Glu Ala Ser Asp Asp Asp Leu Trp Thr Arg Arg Arg Ser Glu Arg Ile 865 870 870 ct 880ttc cac gac gcc tcg gct gct gca cct gcg ccc gtc agc acc gcg 2688 Phe Leu His Asp Ala Ser Ala Ala Ala Pro Ala Pro Val Ser Thr Ala 885 890 895 ccc gcc acc aag acc agc cgc tgc gcc aag ggc ggc ccc ccg 2736 Pro Ala Thr Lys Thr Ser Arg Cys Ala Lys Gly Gly Pro Leu Ser Pro 900 905 910 cgc aag gac gcc ggg cgt gca aag gac agg aag gac ccc agg aag aag 2784 Arg Lys Asp Ala Gly Arg Ala Lys Asp Arg Lys Asp Pro Arg Lys Lys 915 920 925 aag aaa ggg aaa gag gct ggg cca gga gct ggg ctg ccg ccg ccc cga 2832 Lys Lys Gly Lys Glu Ala Gly Pro Gly Ala Gly Leu Pro Pro Pro Arg 930 935 940 gct cct gcc ttg ccc tct agg gct cct cct cct cct cct cct 2880 Ala Pro Ala Leu Pro Ser Glu Ala Arg Ala Pro Pro Pro Pro Pro Pro 945 950 955 960 cct cct cct cat cct cct ctt cct cct cct cct ctt cct cct cct cct 2928 Pro Pro Pro His Pro Pro Leu Pro Pro Pro Pro Leu Pro Pro Pro 965 970 975 ctt cct ctt cgt ctt cct cct ctt cct cct cct cct ctt cct cgt cct 2976 Leu Pro Leu Arg Leu Pro Pro Leu Pro Pro Pro Pro Leu Pro Arg Pro 980 985 990 cat cct cct cct cct cct cct ctt cct cct ctt ctt cct cca cca cag 3024 His Pro Pro Pro Pro Pro Pro Leu Pro Pro Leu Leu Pro Pro Gln 995 1000 1005 acg agg act ctt cct gca gct cgg acg atg agg cag ccc ccg ccc cca 3072 Thr Arg Thr Leu Pro Ala Ala Arg Thr Met Arg Gln Pro Pro Pro 1010 1015 1020 cgg ctg gcc ctt ccg cgc agg cgg cgc tcc cca cca agg cca cca agc 3120 Arg Leu Ala Leu Pro Arg Arg Arg Arg Ser Pro Pro Arg Pro Pro Ser 1025 1030 1035 1040 agg ccg gca agg cgc ggc cct cgg ccc act ccc cag gca aga aga cgc 3168 Arg Pro Ala Arg Arg Gly Pro Arg Pro Thr Pro Gln Ala Arg Arg Arg 1045 1050 1055 ccg cgc ccc agc ccc agg cgc ctc ctc cgc agc cca cac agc ctc tgc 3216 Pro Arg Pro Ser Pro Arg Arg Leu Leu Arg Ser Pro His Ser Leu Cys 1060 1065 1070 agc cca agg ctc agg ccg ggg cca aga gag gac caga 3264 Ser Pro Arg Leu Arg Pro Gly Pro Arg Ala Asp Pro Arg Arg Glu Arg 1075 1080 1085 gcg tcc acc tcc cca cca cca agg agc tgg cca agc ggc agc gcc tgc 3312 Ala Ser Thr Ser Pro Pro Pro Arg Ser Trp Pro Ser Gly Ser Ala Cys 1090 1095 1100 cgt ccg tgg aga acc ggc cca aga tcg ccg cct tcc tgc cag ccc ggc 3360 Arg Pro Trp Arg Thr Gly Pro Arg Ser Pro Pro Ser Cys Gln Pro Gly 1105 1110 1115 1120 agc tct gga agt ggt tcg gca agc cca ccc agc ggc gtg gca 3402 Ser Ser Gly Ser Gly Ser Ala Ser Pro Pro Ser Gly Val Ala 1125 1130 tgaagggcaa ggcccgcaag ctcttctaca aggccatcgt gcgcggcaag gagatgatcc 3462 gtatcgggga ctgtgccgtg ttcctctctg ccggccgccc caacctgccc tacatcggcc 3522 gcatccagag catgtgggag tcgtggggca acaacatggt ggtccgcgtc aagtggttct 3582 accaccccga ggagaccagc ccgggcaagc agttccacca gggccagcac tgggaccaga 3642 agtccagccg cagcctcccg gcggccctgc gggtctccag ccagaggaag gacttcatgg 3702 agcgcgcgct ataccagtcc tcgcatgtgg acgaaaatga cgtgcagacg gtgtcgcaca 3762 agtgcctggt ggtgggcctg gagcagtatg agcagatgct gaagaccaag aagtaccagg 3822 acagcgaggg cctgtactac ctcgcgggca cctacgagcc caccacgggc atgatcttct 3882 ccacggacgg cgtgcccgtg ctctgctgag cccgccgggc cctgcgggcc acctgtgccc 3942 cgagggcggc cagggaccca tctcca tcac tgccatggcg cggagaccac gtgcgttgtg 4002 tgcatgcgag cgctcctgca ggcgtgtgca tggggccagg tgtgcacgtg gatgcccggg 4062 tgagtgtgtg tgcatgcacg tgtgtgcacg catgtgcaca tgcctccagc cccaccttcc 4122 aacccctcag tgcccccagg acaggggccc ctcttagcta tcagggtatg gccggaccgg 4182 cccttcctgc ccagcacgtt gcaagcactt ggccaggccg gccctccagg ctgctgctgc 4242 gtgggggccc gggtgccccc aggtccatgc agactgggga ttcggtgggg aggggcgctt 4302 ctaaggaacc aaactgacgc tcactctggg cttcccaagc acccttagca tggagcccac 4362 cccaaggcct cccaccgtgc atgggacagg gcagcccgat gccagctggc ctacctgact 4422 gtgccagggg ccctgccccc accctctcag gatggcctag acttggggaa cagagccggg 4482 tggggttgca gcccggagtg tctgtcaaag gcaccaggtg gagagggccc ggcacaggcc 4542 caccctggtc caaaccctca cactacagaa aaccccaatg gtgctgaaac tgtcgcccgg 4602 ccacgcctgg cccctcccca cccaggaggg aggtggcact tcttaacctg tacagtttta 4662 ttgtaccaag agactcgccc cgcccctgta tcataagcct ttaaatggag tcaacttttt 4722 aattatatat ataaagataa atatatataa atatatatat aaacttttta aaactgtgaa 4782 aaatagctat gaaattataa aaaaaaacat t ctgacgtgc agaatattat tttttatttc 4842 ctgttagatt atagtgtcta gcaccggctt caccggcctc ccagtcccca gcacaccccc 4902 cgcccacccc accaagtgta ctgtactcac cccccaggat agagaagtgt ttgttaggga 4962 gagaagaggg agaggcagga gccggcccaa gcccagggtc cctgcttggg ccccagaaag 5022 cacttaacca ggccccaagc cttcaaggga aaccaaggcc tcaaccagac aatcttgagg 5082 gaaggaaaag ccagactttg ggtttgtttt ttgggggaat tattggtttt tttttttatg 5142 tttcttttgg aattttgttt gttggcaaat tctgtgtgat cttttttcat aaaaaaaaag 5202 aaaagattta attggaaaaa t 5223 <210> 38 <211> 5196 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3692) .. (4990) <400> 38 cttgcagacc taccgtgcgc agctgcagca ggtggagctg gccttgggcg ccggcctgga 60 ttcgtctgag caggctgacc tgcgccagct gcagggggac ctgaaggagc tcatcgagct 120 caccgaggcc agcctggtgt ctgtcaggaa gagcaggttg ttggccgcgc tggacgaaga 180 gcgcccgggc cgccaggaag atgctgagta ccaggctttc cgggaggcca tcactgaggc 240 ggtggaggca ccagcagcgg cccgtgggtc cggatcagag accgttccta aagcagaggc 300 ggggccagaa tctgcggcag gtgggcagga ggaggaagag ggagaggacg aggaagagct 360 gagtgggaca aaggtgagcg cgccctacta cagctcctgg ggcactctgg agtatcacaa 420 cgccatggtg gtgggaacgg aagaggcgga ggatggctcg gcgggtgtcc gtgtgcttta 480 cctgtacccc actcacaagt ctctgaagcc gtgcccgttc ttcctggagg gaaagtgccg 540 ctttaaggag aactgcaggt tctcccatgg gcaggtggtc tctctggatg agctgcgccc 600 cttccaggac ccagacctga gctccctgca ggccggctct gcgtgtctgg ccaagcacca 660 ggatggcctc tggcacgcag cacgcatcac cgatgtggac aacggctact acacagtcaa 720 gtttgactcg ctgctgctga gggaggccgt ggtggagggg gacggcatcc tgcccccact 780 gcgcacagag gccacagagt ccgactcaga cagcgacggt acgggtgact ccagctatgc 840 cagaggtatg gcagcagctg cggagcccag gagccaggaa ggtggggtca ccctgagagg 900 ctcctggccg gtgagggcac caaccatcta accaaactat tggagagtgt gtgactgcgg 960 cgagggtgcc acctgtgcct gaggaggccg tgtgggtagg ggtagatccg tggcggcctt 1020 tatcttcaag gagtgtgggt gcaacagcta cagtctcatt gatgggaggc catggtcgtg 1080 gctgtggcca tgggagagga ggggcctgga gttgccgagg aagtcacaga aaatgaccaa 1140 ctgatggggc ctggagtgca ggaggggcag ctcctctgca tggcttctca gacttgggac 1200 ctgggtgcct gggatcctgg cagacagagg ttgtgtccag acagccagca tggaagtttc 1260 gggaatggga actggtgggc agtgtccagc tctccagagg ggtgtgtgta tgcgtgtgcg 1320 tgtgtgtgta tatatgtggg aggtcacctg acccaagcat ggcgggctga gtccaggagg 1380 ggtctgcatg ttggaggtgt acccagggat cagtgatggt ggtttctgaa gccccatgtc 1440 cctggtgaag gaggactgaa ccaaggactc tgtgagggca ggtgaggcgc tcacagcctc 1500 gcgaaggtgg agaagggcag gggcaggaga gggctgcgga ggaggggcca cggtgcagca 1560 ggccgtgggg actgccatgc actctgcctg gtgtcacatg cccacagcag cctcggtgac 1620 gagagcacgg agcccaagag gtggggtgtc gtggctctgc ccaggatctg agctcattgg 1680 tcaaagcccg ggtcacca tg cacaatcctc tggcctggct gggccactgc cctctgtcca 1740 tctcttgcag tggtggggtc ggacgccgtg gactctgcac agtcctctgc cctctgtccg 1800 tctcttgcag tggtggggtc agatgctgtg gactctggga cctgcagctc tgcctttgct 1860 ggctgggagg tgcacacgcg aggtataggc tccagactcc tcaccaagat gggctatgag 1920 tttggcaagg gtttgggccg acacgcggaa ggccgggtgg agcccatcca tgctgtggtg 1980 ttgcctcgag ggaagtcgct ggaccagtgt gtggagaccc tgcagaagca gaccagggtt 2040 ggcaaggctg gcaccaacaa gccccccagg tgccggggaa gaggggccag gcctgggggc 2100 cgcccagctc ctcggaatgt gtttgacttc ctcaatgaaa agctgcaagg tcaggctcct 2160 ggggccctag aagccggggc ggccccagcg gggaggagga gcaaggacat gtaccatgcc 2220 agcaagagtg ccaagcgggc cctgagcctg cggctcttcc agactgagga gaagatcgag 2280 cgaacccagc gggacatcag gagcatccag gaggctctcg cccgcaacgc tggccggcat 2340 agcgtggcgt cagcccagct gcaggagaag ctggcaggag cccagcgcca gctggggcag 2400 ctccgggctc aggaagccgg cctgcagcag gagcagagga aggcagacac ccacaagaag 2460 atgactgagt tctagagacc ccacaagcac tatggacgaa gcgtgggacc ccagcacggg 2520 ctgccctcag gaagaccagt gt tgcccgag gaggggccgg cctgctggcc tggggcgtgc 2580 ggacactgct gagtggagac agagctgcgg ggtcccatct ggacacttac ttgcccacct 2640 gccagtgtct tgggcatttc cttggcaagg acattaaagt gatttcatca cagtgtcatt 2700 cagtggagat cagctggctg cagggtctct ggggagagaa gggtctgtgc agggctgtgg 2760 tgagagacgg gctgggctgg aggggcctag gaggccggca ttctcccttc ttacccttct 2820 ctgaccaagg cagatcggag gccagggtgc ccgccaggct gcctgacacc cacagatggg 2880 tggagctcag tgctgctcca gcgggcgaga cgggcgggag aggactgtgg cccaccacgt 2940 ggggcactct tggtgaggca ggcggacctg gccctgtggg tttgggggtt ctgtgccagc 3000 tctgctcacg tcttcgtgtg tggaggggtt gtgagttagg ctgtcagaac agtgcgggct 3060 agaggcgcac acgtttcatc taggcttcgg gcggggcgca gcaggtgggt gaggctgcgg 3120 tggtggctgc tgcccagggt gggaggctca ggggaggcgc ttggcgacag gagcaggaag 3180 tgatgaggtg gggagctcag ccgagggctg cacaaagacc ttcctggcct gccccagaca 3240 gagctgagga cccctggccg tgggcttggt aagtgccctc ctggggggca gctggggtct 3300 gggaggcctt gggatgtggc tgcagctggg tcagtcagcc aggctgaagc ccactccctg 3360 ggtctgagca gactggcccc aaactcca ga gaccacccct caccccccag cttctgtctc 3420 tgctgctgga ctgtgctgtt tgtaaggcat cccccacccc gagaagttct gctaagatcc 3480 ccaagaaggg gacagatcct ctctggcaga gacactggca gacaagaaga gccagagaga 3540 agtggggtgg gggcatcagc acccccagca gctgctgctg cctgctgacc cagcctccag 3600 ctcctccggg tgcagggtcc ctcctgctga ccagcctcca gctcttccca gttctgggct 3660 ccgcagcgag cggcttgggg gcactacctg a cac agg aga cca tgt ctg ggc 3712 His Arg Arg Pro Cys Leu Gly 1 5 aga ggg tgg ctg cag gtg gag tct gtg gcc tgt ggc gca cac cca ggg 3760 Arg Gly Trp Leu Gln Val Glu Ser Val Ala Cys Gly Ala His Pro Gly 10 15 20 gct ccc ccg atg ctg gtt act atc tgg gct atg gtg gcc aca gct gtc 3808 Ala Pro Pro Met Leu Val Thr Ile Trp Ala Met Val Ala Thr Ala Val 25 30 35 ctg ccc ctc ctc acg gcc gtg ctg ggt gtt acc gtg gtc acc cgc agg 3856 Leu Pro Leu Leu Thr Ala Val Leu Gly Val Thr Val Val Thr Arg Arg 40 45 50 55 gac acg gag ggg cca ggc aga gca gcc cta gtt cac ctc acc ggg agc 3904 Asp Thr Glu Gly Pro Gly Arg Ala Ala Leu Val His Leu Thr Gly Ser 60 65 70 ccc cgc cag aag gtg ggc acc tct ggg agg gag gga ctg cca ggc ctt 3952 Pro Arg Gln Lys Val Gly Thr Ser Gly Arg Glu Gly Leu Pro Gly Leu 75 80 85 ggg gct tcc tgt gct gag tca gag ctg gaa cgg gag acg gag ccc 4000 Gly Ala Ser Cys Ala Glu Ser Glu Leu Glu Arg Glu Thr Gln Glu Pro 90 95 100 cgc agc cgc ggg agg tgc aga ttt ggg gct gcc agg tgg cgc cag gtc 4048 Arg Ser Arg Gly Arg Cys Arg Phe Gly Ala Ala Arg Trp Arg Gln Val 105 110 115 ccc ttg gcc agc ccc cag cgc ccc ttt ctt ctg tcc cca ggg cct cgg 4096 Pro Leu Ala Ser Pro Gln Arg Pro Phe Leu Leu Ser Pro Gly Pro Arg 120 125 130 135 ctt cac agg atg ggg ctg cca gtg tcc tgg gcc cct cct gcc ctc tgg 4144 Leu His Arg Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp 140 145 150 gtt cta ggg tgc tgc gcc ctg ctc ctc tcg ctg tgg gcg ctg Tgc aca 4 Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr 155 160 165 gcc tgc cgc agg ccc gag gac gct gta gcc ccc agg aag agg gcg cgg 4240 Ala Cys Arg Arg Pro Glu Asp Ala Val Ala Pro Arg Lys Arg Ala Arg 1 70 175 180 agg cag cgg gcg agg ctg cag ggc agt gcg acg gcg gcg gaa gcg tcc 4288 Arg Gln Arg Ala Arg Leu Gln Gly Ser Ala Thr Ala Ala Glu Ala Ser 185 190 195 cta ctg agg cgg acc cc cc tc aag tcg gac acc aga 4336 Leu Leu Arg Arg Thr His Leu Cys Ser Leu Ser Lys Ser Asp Thr Arg 200 205 210 215 ctg cac gag ctg cac cgg ggc ccg cgc agc agc agg gct ctg cgg cct 4384 Leu His Glu Leu His Arg Gly Pro Arg Ser Ser Arg Ala Leu Arg Pro 220 225 230 gcc agc atg gat ctc ctg cgc cca cac tgg ctg gag gtg tcc agg gac 4432 Ala Ser Met Asp Leu Leu Arg Pro His Trp Leu Glu Val Ser Arg Asp 235 240 245 atc acc gga ccg cag gca gcc ccc tct gcc ttc cca cac cag gag ctg 4480 Ile Thr Gly Pro Gln Ala Ala Pro Ser Ala Phe Pro His Gln Glu Leu 250 255 260 ccc cgg gct ctg ccg gca gct gca gcc acc gca ggg tgc gct ggc ct 4528 Pro Arg Ala Leu Pro Ala Ala Ala Ala Thr Ala Gly Cys Ala Gly Leu 265 270 275 gag gcc acc tat tcc aac gtg ggg ctg gcg gcc ctt ccc ggg gtc agc 4576 Glu Ala Thr Tyr Ser Asn Val Gly Leu Ala Ala L eu Pro Gly Val Ser 280 285 290 295 ctg gg agt ccc caa gag cca cag cag ggg aag act gag 4672 Lys Gly Thr His Arg Ser Pro Gln Glu Pro Gln Gln Gly Lys Thr Glu 315 320 325 gtg acc ccg gcc gct cag gtg gac gtc ctg tac tcc agg gtc tgc aag 4720 Val Thr Pro Ala Ala Gln Val Asp Val Leu Tyr Ser Arg Val Cys Lys 330 335 340 cct aaa agg agg gac cca gga ccc acc aca gac ccg ctg gac ccc aag 4768 Pro Lys Arg Arg Asp Pro Gly Pro Thr Thr Asp Pro Leu Asp Pro Lys 345 350 355 ggc cag gga gcg att ctg gcc ctg gcg ggt gac ctg gcc tac cag acc 4816 Gly Gln Gly Ala Ile Leu Ala Leu Ala Gly Asp Leu Ala Tyr Gln Thr 360 365 370 375 ctc ccg ctc agg gccg gc gc gc ggc ccc ctg gaa aac gtg 4864 Leu Pro Leu Arg Ala Leu Asp Val Asp Ser Gly Pro Leu Glu Asn Val 380 385 390 tat gag agc atc cgg gag ctg ggg gac cct gct ggc agg agc agc acg 4912 Tyr Glu Ser Ile u Leu Gly Asp Pro Ala Gly Arg Ser Ser Thr 395 400 405 tgc ggg gct ggg acg ccc cct gct tcc agc tgc ccc agc cta ggg agg 4960 Cys Gly Ala Gly Thr Pro Pro Ala Ser Ser Cys Pro Ser Leu Gly Arg 410 415 420 ggc tgg aga ccc ctc cct gcc tcc ctg ccc tgaacactca aggacctgtg 5010 Gly Trp Arg Pro Leu Pro Ala Ser Leu Pro 425 430 ctccttcctc cagagtgagg cccgtccccc gccccgcccc gcctcacagc tgacagcgcc 5070 agtcccaggt ccccgggccg ccagcccgtg aggtccgtga ggtcctggcc gctctgacag 5130 ccgcggcctc cccgggctcc agagaaggcc cgcgtctaaa taaagcgcca gcgcaggatg 5190 aaagcg 5196 <210> 39 <211> 4991 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (318) .. (1256) <400> 39 ctaacgggca gtagagtgtc cggcttcggt gccgagtgcc accgcgagtg ggccgagacg 60 cggagggagg cgcggccgga gctcgggtcg ccgacgctgg ccaggaccgc gcttcttccc 120 ggcggcaggc ggcgcggtcc ccgtgactct cagaagccgc ccgatgtaga gccgcttctt 180 tgtctcatac ccctgaccat tcgtgcgtgg cacggagccg ggtatctgcg ggtacagcga 240 tgaacagggc agacgtggcc aggccacact accatcaccc ctttctccaa ccctgaaaaa 300 cagttcctga gacctga act att gac cat cat ttt aat cgg acc aac tgc 350 Thr Ile Asp His His Phe Asn Arg Thr Asn Cys 1 5 10 agc tgt aac aag ctt ctc ttt ggg gtc aca atg acc act gca ggc agg 398 Ser Cys Asn Lys Leu Leu Phe Gly Val Thr Met Thr Thr Ala Gly Arg 15 20 25 gga aat tta ggc ctc atc ccc agg agc act gct ttc cag aag caa gag 446 Gly Asn Leu Gly Leu Ile Pro Arg Ser Thr Ala Phe Gln Lys Gln Glu 30 35 40 ggg cgc ctg act gtg aag cag gag cca gca aac cag acc tgg ggg cag 494 Gly Arg Leu Thr Val Lys Gln Glu Pro Ala Asn Gln Thr Trp Gly Gln 45 50 55 ggc agc agt ctc cag aag aac tat cct cct gtc tgc gaa atc ttc cgg 542 Gly Ser Ser Leu Gln Lys AsnyrPro Pro Val Cys Glu Ile Phe Arg 60 65 70 75 cta cac ttc agg caa ttg tgt tac cac gag atg tct ggg ccg cag gaa 590 Leu His Phe Arg Gln Leu Cys Tyr His Glu Met Ser Gly Pro Gln Glu 80 85 90 gca ttg agc cgg ctt cgg gag ctc tgc cgc tgg tgg ctc atg cca gag 638 Ala Leu Ser Arg Leu Arg Glu Leu Cys Arg Trp Trp Leu Met Pro Glu 95 100 105 gtg cac acc aag gag cag atc ctg gag ctg ctg gtg ttg gtg ttg gtg ttg gtg gtg gtg 686 Val His Thr Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln Phe 110 115 120 ctg agc atc ctc cct ggg gag ctc cgg acc tgg gtg cag ctg cat cac 734 Leu Ser Ile Leu Pro Gly Glu Leu Arg Thr Trp Val Gln Leu His His 125 130 135 cct gag agt ggt gag gag gct gtg gct gtg gtg gag gat ttc cag aga 782 Pro Glu Ser Gly Glu Glu Ala Val Ala Val Val Glu Asp Phe Gln Arg 140 145 150 155 cac ctc agt gga tca gag gag gtt tca gcc cca gca cag aaa cag gaa 830 His Leu Ser Gly Ser Glu Glu Val Ser Ala Pro Ala Gln Lys Gln Glu 160 165 170 atg cat ttt gag gag aca aca gct ctg ggt aca aca aag gaa tct cct 878 Met His Phe Glu Glu Thr Thr Ala Leu Gly Thr Thr Lys Glu Ser Pro 175 180 185 cct acc tca ccc ctc agt ggg ggc tca gcc cct gga gcc cac ctg gag 926 Pro Thr Ser Pro Leu Ser Gly Gly Ser Ala Pro Gly Ala His Leu Glu 190 195 200 cct cct tat gac cca ggg aca cac cac ctc ccc agt ggg gac ttc gct 974 Pro Pro Tyr Asp Pro Gly Thr His His Leu Pro Ser Gly Asp Phe Ala 205 210 215 caa tgt act tct cca gtt cct acc ctt cct caa gtg ggg aac tca gga 1022 Gln Cys Thr Ser Pro Val Pro Thr Leu Pro Gln Val Gly Asn Ser Gly 220 225 230 235 gac caa gca ggg gca act gta ctt cgg atg gtc agg ccc cag gat act 1070 Asp Gln Ala Gly Ala Thr Val Leu Arg Met Val Arg Pro Gln Asp Thr 240 245 250 gtg gca tat gag gac cta tct gta gac tac act cag aag aaa tgg aaa 1118 Val Ala Tyr Glu Asp Leu Ser Val Asp Tyr Thr Gln Lys Lys Trp Lys 255 260 265 agt ctc aca ctc agt cag aga gcc ctg cag tgg aac atg atg cca gaa 1166 Ser Leu Thr Leu Ser Gln Arg Ala Leu Gln Trp Asn Met Met Pro Glu 270 275 280 aat cac cat agc atg gcc tcc ttg gga atg gtt gct ttc aac att Hitc 1214 Asn s His Ser Met Ala Ser Leu Gly Met Val Ala Phe Asn Ile Phe 285 290 295 cag gtt gtg aaa ggt ttg cca cga ttc tca ggg gtg tgg ttc 1256 Gln Val Val Lys Gly Leu Pro Arg Phe Ser Gly Val Trp Phe 300 305 310 taagctgcat cagtggaaca aatacaaaat gctgtcctcc tcccaggctg gaaggcagtg 1316 cactttctcc tcttaacagc cagactagcg ggtgaggagt cagtgctgtg acccaggcca 1376 agctggagtg tccgcatggc tttttctctg accagtgggg attccatcta tcttgaggcg 1436 tgctggctgg gccccgtttc cacaccagca catggtgaga cagggtagct tatcaacagg 1496 ctgctgggcc ttaatactga cagtgagtgt ggcgggtcac agccaggaag ggactaacac 1556 agatgcccgc ccagccccca ctgctggcct aattttagaa taccacggaa aaaagctttg 1616 atgaagacaa caggaagtca acacagcaga gagtggtgtg gacaacccag aagccagcct 1676 cacgcattcc atgcccacag ttaacgatga caacaacagc agtaaaacaa aggtacaggt 1736 gaaaagcagc gctcggggtg tgctgctgca agctggggaa ggtgcgtgct caacttggat 1796 gggacacacc tagtctttct tcaagtccct ggattcaaag agcttcaacc gttcttgcac 1856 cgtcaggcct tccttcagac tcttggacct gatgtttctg agttgccagg tgacacagga 1916 tctgtctttc ttcaagaag t cagggttgct tttagatttc attatatcat atccggacac 1976 catggcactg tcaggggact tttcccccag tgcttccgtt gcagccttaa gctgctcttt 2036 caacctgctg atgtcacagt cagccttagc ctttgcgatg ctgagctctg tgtagatgtc 2096 tttgtggtgt cacttgcgta cttcttgtcc cacagtgctg tctgcagctc atccttgagg 2156 gagctaatct cctgtttcag gtactgtatt tccgattcct atatccgcaa taagacttct 2216 agttcatagg catccttgcc ctgtgcaagg ggtgacccag tggcctcccc accgccgtcc 2276 ccagtcagca gcgtccgcaa ccgtgtgatc tctgcagcca ggcggttgtt cagctcctgg 2336 ttgtgggcat tgagctcctg gttctcacgc tggcactgcc gcagggcctg ctgcccggcc 2396 tccagcgcct gggccagatg ggcattctcc aggcacttct gcgagtactg ctccgagagg 2456 acctccagtt cccgctgcac cgactgcagc tcctccaggt actggcgccg cagggcctca 2516 acatccgagt tgacgctgct gatctgggac cgctggctct tctccagctc ccgctccatc 2576 tcctcccggt gggcgttctt catggcttcg atggctgaga tggtggccgc tgtctcctcg 2636 gctaggagtc ggtctttctc ttctcgaagt ttctctagct cccgctggtg ctgcctctgg 2696 agatcttcaa tcttcttctg gtgcgtttct tccattgctg caaaccctca cttgcacgtg 2756 gcctgcagca tgtagccctc acg ggcgctc tgctcccggc ccagggccac cctcagctgg 2816 tcctgcagga gccggttctg ctccagaagg tctgaggcct ccttctggct ctgctccagc 2876 tccttcttga gcagagaggt cagctcgtgt gtggagagcc ggtcaccccc atcttcagaa 2936 gacaggtgga cggggacgat gggcacctgc ttctcttccc ggagaggcgt ggtctccacc 2996 tgatgccacc gctgctcgat ctccacgtgg acgttatgcg tcttgaggtc gctcacaggc 3056 agccctgggc tccggtccac ctccatgcgc agggctgcat cctcagtgcc tggcccgcct 3116 gtggcgtcca gcatcccgaa gtgcttgcgg cgctcctccc gcctccgtgc acgctcccgc 3176 tccagctccc caggctccgc ctcagggcgc aggggctcgt gggtgtcagc aggccccaca 3236 ccgcccaccc gctcctgatt cagggcctgc tggatgggac ggaactcagc ccagtcaaag 3296 gtcttggaga ggccctctcg cctccgctcc cacgtgcggc tcctcttctg ctcagggtcc 3356 ggctcccccg gctctgcctc ttgcttctca gtaggcctcg ggcaggtctc aaaagagcag 3416 ctgctcttgt ttttttcctc tggcaaccag ctggtcacat ccggggcggt ggtcgggtgc 3476 acatgcttca tgatggtctg gatccagttc cgccgaatcc cagatgtcat ggccgacagg 3536 gtaaactcgc cctcctttgt atgtatctgg aagccatagt ttctctgaac tggatactct 3596 gtgacatcgt aacatgcaga caagtcaat t tctccatcca agtcggctgc ctcctcagcc 3656 actgaatccc tgtagtatct caggctttga tcggcgagga caaaccagtg tttcttccac 3716 tggctgtcct catactgctt agtcagccag cctttcttga aattcagcag gtcgggcgtc 3776 acggagggct ctgtggacct cctgtccagt gacttggctc ttcggtgtgg agacggggga 3836 agccgaggcg tctgggagag gagcttgggg ggggggcttc attggtgaag tcctgcttgc 3896 tagggaacgc ccttttctcg ctgcggccct ggcgtgtgtc actggatggc gagggcccca 3956 ctgcattggt ctccatgtgc tctgccttct caatgtccaa ggcctcaaac ttttcaatca 4016 cctgggacct cctgtggttg ggggtgctgg ggctgggagg ggagagcggc gggggcagct 4076 gctgttcttc ggccttcaag tcgtgtttgg tcttctccag agagaagtag ctgctctccc 4136 cccggacttt gcggccacag tccatgcggt cgctactcat ggcgctctcc tcttctttgc 4196 tctccagccc aggttcccgc agggagctgg cagcaggagg ctggctctgg ctgggactct 4256 gagctggact cagactgctg ccatctggct ggtccttggt cctcatttct tcctgccaga 4316 gtgtggactt ggtggtgggg actttctcag cactggggat gctgctgctg ctgctgctgc 4376 tggtggtaac agccaccttg gcaggcccag gctcctgcgg tgtggggggc tccactttcc 4436 atttcttctt ctgattctgc ttgttggtcc ggg gatagac catgagcatc tccagccacc 4496 cactgacgat ctccttggtc tccgcccgga tgaaatgctc cttctcaggc gtcagaatac 4556 acagggagaa cctctggccc gtgcggccct ccccatccac cacatctgtg cactggttca 4616 tgttgatggt gccctgagga agggtcgtgg gcatctcatc cagggcgtag cgcaagaggc 4676 catgctcgta aaggatgaag aactgtcgct gccatttcgg agaccggtgc actgagttgt 4736 caaagtcggt cccatctgga gccaggagga gccaaccgcc ataaatgggt tttgcctgcg 4796 tcaggtcctc gtcgttgagg agatgcgact cgcggggctg gaagcagttc tgacacttgc 4856 tcttgttgaa gatgttggcc tggaatttcc tgcacgggtt ctccttggct gccgacatgg 4916 tcggcgcggc ggcggcggcg gcgcaggccc agccggcctg gcgctcccgg cgggctaggg 4976 gctcagcgcg gccgc 4991 <210> 40 <211> 5123 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (968) .. (2281) <400> 40 taaagccaca cagaggaagt tacgcagccc ggatcagacc gagagataaa agccccgatg 60 gtgatcgtga gtgatggcaa gaggatttag cctcggcatt aacttggaac ggctgcgggc 120 ggctccctgg ccccgatctg acggcggcgg cggcggcggc cacagcggcg ggagcggcgc 180 ggggaaggag cagcggctcg cagccctcgg cccgcgcccc cacccagcgc cagcccgagg 240 ggggaggcgc agcgccggag ggtggcggtc ctcggccctc ccaggtctcc gcgccgggaa 300 gccgctccga gccgggattg tgcctatgat tggggggctg tttctcagtg cctggctctt 360 catggttggc cagcacgtgg agcactctgt tcatctgtac atataggtgt tgttgctaat 420 gagctctctc tctctcctcc cctcttacaa tgaaagacaa gtcagacccc aggtacctgg 480 atggattgag agctgagatc tcagaaactt cataataagt tgccgatggc taccagccaa 540 ggctggaggg ttgttttgcc gttgtgttga gcacgtcacc cattaagagc cctttaaaga 600 cctggattga ttggaaggac aaaaattaaa agcaatctga tccagcctca tgcaggatcc 660 ctgcggattt tctccttatc ccatttccat ccactgtcac aatttgagaa tctgcctgat 720 ttgatcagat tcacctccag gggaggtgtg ataccagggt taggaggacg tgaagttatg 780 ggcaactttc tgatctgtcc atcagcagtc tgagaaacgc tggctctgaa ttttccgtgt 840 cggccttttg g aaacaacaa gttcctcgct gtttgcaaag cttcagtgct cgggtccctg 900 ggacaccccg gccaccctcg cctggtagat gtggcatttc catgctgagg ccgcgagtcc 960 cgcctga ccc cgt cgc tgc ctc tg ag gc tc gc cc gc cc gc ct gc cc gc ct g gcc atg ctg cat ctg ctg gcg ctc ttc ctg cac tgc 1057 Ala Asp Cys Ala Ala Met Leu His Leu Leu Ala Leu Phe Leu His Cys 15 20 25 30 ctc cct ctg gcc tct ggg gac tat gac atc tgc aaa tcc 1 Leu Pro Leu Ala Ser Gly Asp Tyr Asp Ile Cys Lys Ser Trp Val Thr 35 40 45 aca gat gag ggc ccc acc tgg gag ttc tac gcc tgc cag ccc aag gtg 1153 Thr Asp Glu Gly Pro Thr Trp Glu Phe Tyr Ala Cys Gln Pro Lys Val 50 55 60 atg cgc ctg aag gac tac gtc aag gtg aag gtg gag ccc tca ggc atc 1201 Met Arg Leu Lys Asp Tyr Val Lys Val Lys Val Glu Pro Ser Gly Ile 65 70 75 aca tgt gga gac ccc cct gag agg ttc tgc tcc cat gag aat ccc tac 1249 Thr Cys Gly Asp Pro Pro Glu Arg Phe Cys Ser His Glu Asn Pro Tyr 80 85 90 cta tgc agc aac gag tgt ga c gcc tcc aac ccg gac ctg gcc cac ccg 1297 Leu Cys Ser Asn Glu Cys Asp Ala Ser Asn Pro Asp Leu Ala His Pro 95 100 105 110 ccc agg ctc atg ttc gac aag gag gag gag ggc ctg gcc acc tac tgg 1345 Pro Arg Leu Met Phe Asp Lys Glu Glu Glu Gly Leu Ala Thr Tyr Trp 115 120 125 cag agc atc acc tgg agc cgc tac ccc agc ccg ctg gaa gcc aac atc 1393 Gln Ser Ile Thr Trp Ser Arg Tyr Pro Ser Pro Leu Glu Ala Asn Ile 130 135 140 acc ctt tcg tgg aac aag acc gtg gag ctg acc gac gac gtg gtg atg 1441 Thr Leu Ser Trp Asn Lys Thr Val Glu Leu Thr Asp Asp Val Val Met 145 150 155 acc ttc gag tac ggc cgg ccc acg gtc atg gtc ctg gag aag tcc ctg 1489 Thr Phe Glu Tyr Gly Arg Pro Thr Val Met Val Leu Glu Lys Ser Leu 160 165 170 gac aac ggg cgc acc tgg cag ccc tac cag ttc tac gcc gag gac tgc 1537 Asp Asn Gly Arg Thr Trp Gln Pro Tyr Gln Phe Tyr Ala Glu Asp Cys 175 180 185 190 atg gag gcc ttc ggt atg tcc gcc cgc cgg gcc cgc gac atg tca tcc 1585 Met Glu Ala Phe Gly Met Ser Ala Arg Arg Ala Arg Asp Met Ser Ser 195 200 205 tcc agc gcg cac cgc gtg ctc tgc acc gag gag tac tcg cgc tgg gca 1633 Ser Ser Ala His Arg Val Leu Cys Thr Glu Glu Tyr Ser Arg Trp Ala 210 215 220 ggc tcc aag aag gag aag cac gtg cgc ttc gag ggt ttc 1681 Gly Ser Lys Lys Glu Lys His Val Arg Phe Glu Val Arg Asp Arg Phe 225 230 235 gcc atc ttt gcc ggc ccc gac ctg cgc aac atg gac aac ctc tac acg 1729 Ala Ile Phe Ala Gly Pro Asp Leu Arg Asn Met Asn Leu Tyr Thr 240 245 250 cgg ctg gag agc gcc aag ggc ctc aag gag ttc ttc acc ctc acc gac 1777 Arg Leu Glu Ser Ala Lys Gly Leu Lys Glu Phe Phe Thrrl Leu Thr Asp 255 260 265 270 270 ctg cgc atg cgg ctg cgc ccg gcg ctg ggc ggc acc tat gtg cag 1825 Leu Arg Met Arg Leu Leu Arg Pro Ala Leu Gly Gly Thr Tyr Val Gln 275 280 285 cgg gag aac ctc tac aag tac ttc tac gcc atc tcc aac atc gag gclug Leu Tyr Lys Tyr Phe Tyr Ala Ile Ser Asn Ile Glu Val 290 295 300 atc ggc agg tgc aag tgc aac ctg cac gcc aac ctg tgc tcc atg cgc 1921 Ile Gly Arg Cys Lys Cys Asn Leu His Ala Asn Leu Cys Ser M Arg 305 310 315 gag ggc agc ctg cag tgc gag tgc gag cac aac acc acc ggc ccc gac 1969 Glu Gly Ser Leu Gln Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp 320 325 330 tgc ggc aag tgc aag aag aat acctcc cgg tcc tgg cgg gcc ggc 2017 Cys Gly Lys Cys Lys Lys Asn Phe Arg Thr Arg Ser Trp Arg Ala Gly 335 340 345 350 350 tcc tac ctg ccg ctg ccc cat ggc tct ccc aac gcc tgt gcc gct gca 2065 Ser Tyr Leu Pro Le Pro His Gly Ser Pro Asn Ala Cys Ala Ala Ala 355 360 365 ggt tcc ttt ggc aca act ctc agg ctc tcc cag gag ctc cat cag tgc 2113 Gly Ser Phe Gly Thr Thr Lele Arg Leu Ser Gln Glu Leu His Gln Cys 370 375 380 tgc ttt gga aaa cgg gac agg act ttt tgc agg ttt ctt ggc ccc tgg 2161 Cys Phe Gly Lys Arg Asp Arg Thr Phe Cys Arg Ser Leu Gly Pro Trp 385 390 395 gtg ggc tcc ctg ctc ctc ctg cca ccc cg cca ccc cg cca ccc acg cca ccc acg cca ccc gga 2209 Val Gly Ser Leu Leu Leu Leu Pro Pro Thr Pro Leu Leu Ser Pro Gly 400 405 410 tct ggg aga gca gtc tct cct gcc agt caa gag tgg ggt gac ctt ccc 2257 Ser Gly Arg Ala Val Ser Pro Ala Ser Gln G lu Trp Gly Asp Leu Pro 415 420 425 430 cca cca ggg gca gaa tcc acc ccc tagcctaacc atgggggcag cctccctctg 2311 Pro Pro Gly Ala Glu Ser Thr Pro 435 ggcagcctct gcagccagct tgtcccaggg ctctgctcgt ccaggtcagc tcaggtccca 2371 ggggagtcgg accagggagg ggcatctgca ggaggtgggg gtcctgagag ttccccagga 2431 gggcgagggc gacatggcgc ccacaggtta tcagtaaatg tcatcgagac tgtccccaga 2491 cactcacagg gtgccaggca cggtctctcc tttcagcctt gcaaacccct ccccctggga 2551 ggtcgccatc tgctctgcga ggcagcagga gaggactggc caatgtcaaa gagccagccg 2611 ggagcagacc ccaaatctca gagatgcttc tggggtgcac cgtcaccctc caccagggct 2671 ctgtggggcc ccacatccca cccaagttgt ccctcccgga cccagggggc ccctggctgg 2731 gaagccagtg agccgagagg gcgccagaaa gaagctggac cctgcaggga cgctggtctg 2791 cacagccgtc gtaagttgct tctctgtggt gtccccaccc cggcaacccc ccaaccctct 2851 cttgcttttc ccatctctca ccaggcatca gcaggtccca gaaagacccc gaccccaaag 2911 gccctgtggc cactgcggcc accacagcca tgacaggggc ccctactact cctgtcccct 2971 ccacgtccac tgcctgggcc cccatggcgc ccagcacccc acagcccaca ggtgggtgcc 3031 ag ggtacagc gacccctgtc atcccaccct ctcctgcttc tagcctgggt ccctgcctct 3091 cttggggtgg gagggtcggc agccctgggc agagagcagg ggcttggctc ttagaataga 3151 gacgctagaa ccctagagct gggaggccac aggccaaagg ggcttgagga cacctgggtc 3211 aacctgttcc tgagcccagc caggggattc agggatcagt tcagcttcca aagtcgtctt 3271 cctcctgccc ttcaagccat tgcttggaag ggctcccaga ccattgtggc cagacggctg 3331 caggaactga gaggaaaggt gctgggggca gcgaggccat cctgacatgc agccaaagac 3391 tggccttatc tcccaatggt gcttctgcct ccgtggtccc tggagccccg cccacaccct 3451 gtccccacct ggcccccagg gcctctctgt ccttagcccc tcagcagcac accggtggga 3511 tggatggagc agggttagcc cagaaagcaa atgtctctga tcagcagggc aaagggagcc 3571 tctggagctg agtttggaca ccgtgggctg ctgggaatgt ggaggctgtg tgtgtagtgc 3631 aaggccaggc cagggccaga cgtcctgccc cctcaggggt ctgccacaga caggcatgga 3691 aacctgattc tcgctcccct ccaacggagg gattcacgtg tattcaaggc tgggggtgct 3751 ggagtgggcc tctgctctca cctggactca cctggggagt atccctgcac tctgtgcagt 3811 gcaggtgcca ggggtctgaa aggatttatc cttcccagag ggcaccagga agacgatgac 3871 caagggga at tcttcctggt cccagccagg gaggggtgct ccaatagcct gccacaccct 3931 gtcccccgcc accctgcagg gaggacctgg tggggactcc tggccccttg ggtagtgccc 3991 tggccctcca tctctctgat ccaaggagac ctgccccact gatccttccc ccttgggggg 4051 tggcatttct aaagggcaga gtcccctcca tcagctcctg cctcggcctg ttgctgggtg 4111 gacactcagg ctccccagac aggggcaaat gctgagagaa agacctcctc cttcctaggc 4171 catccagagc agctcccctg ggggcagcac accccacctc tttctacatc cttccttttc 4231 tgcaggaggc atttacagga ggcaggggct agccaaaaga ttggaggatt tccgggaagc 4291 ctcctgaccc aggaatcctc tttggggtgg aagacatggg tcactctgag aattctggac 4351 ttcagacata ggttggccca gccacaaggg acctgtgctt tgctgctgag cctgtggtgg 4411 gcagacagaa gcaaaaacag tggtggtggg tgctgtgcct gtctccaaac aggggtttgg 4471 ctgggaggcc agatactctc catatcacat gtgcaagtgc acacatgcac acacacacat 4531 gcatgcacac acacaggcat gcacacgcac atgtacacac acacacacac agaggaatcc 4591 atttgcagag ctgcttctga cttggtgcca gggcagccgt gggaggctgg gcagattgtg 4651 caaagttggg aattaaagag gaaaagtcag aggccagagt gggaaatgca ggggaggtga 4711 gggtccccag ga ccccctca gtgagcagaa ggcacaccct ccctctcggc aagacagtgc 4771 tgctctgcac cctcagccct gtatcaagaa gcaggacatt aggggaggag gtggctccaa 4831 tgtgacagcc agtggcccct acagcccaca tctaggggct cctccctcct cttcagcaac 4891 tgaagcccct gtccagagcc cccattaatg aaaacgatca ttgcagtagc tgagggtgag 4951 ttctcctggg ctgtgctcgt atcattgtat catcatatca ttgtattctg ggctcacagc 5011 tccgtgagat ggaggctgtt attttcctag tcccacaggt gaggggatcg aggcttagga 5071 agaagcagct ggattttatg atatgtaaat tacacctcaa tcaagctgtt tc 5123 <210> 41 <211> 5417 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1515) <400> 41 cag agc tct gac tta gcc gtg cca acc atg gcc ggt cca cct ccc agc 48 Gln Ser Ser Asp Leu Ala Val Pro Thr Met Ala Gly Pro Pro Pro Ser 1 5 10 15 acc gtg gac ggg cct ctc tcg gct tct cag gag agc agc ttt cat ggg 96 Thr Val Asp Gly Pro Leu Ser Ala Ser Gln Glu Ser Ser Phe His Gly 20 25 30 aat act gtc tgc ctt cct tcc gaa acc tct ttc act gac tcg gag cca 144 Asn Thr Val Cys Leu Pro Ser Glu Thr Ser Phe Thr Asp Ser Glu Pro 35 40 45 ccg gct ggg aaa gac gga cat ccc aga gat ccc tca gcg gtc agc ggc 192 Pro Ala Gly Lys Asp Gly His Pro Arg Asp Pro Ser Ala Val Ser Gly 50 55 60 gtc cct ggg aag gac agc aga gac ggc agt gag agg gcc cca aag tca 240 Val Pro Gly Lys Asp Ser Arg Asp Gly Ser Glu Arg Ala Pro Lys Ser 65 70 75 80 cca gat gct ctg gag tcg gct cag tcg gag gag gaa gtg gac gag ctg 288 Pro Asp Ala Leu Glu Ser Ala Gln Ser Glu Glu Glu Val Asp Glu Leu 85 90 95 tcc ctc att gac cac aac gaa att atg tcc agg ctg acg ctc aag cag 336 Ser Leu Ile Asp His Asn Glu Ile Met Ser Arg Leu Thr Leu Lys Gln 100 105 110 gag ggt gat gac ggg ccg gac gtc cgc gga gga tct ggg gac atc tta 384 Glu Gly Asp Asp Gly Pro Asp Val Arg Gly Gly Ser Gly Asp Ile Leu 115 120 125 ctg gtc cat gct act gag act gac agg aaa gat ttg gtt tac tgc 432 Leu Val His Ala Thr Glu Thr Asp Arg Lys Asp Leu Val Leu Tyr Cys 130 135 140 gag gca ttc ctg acc acc tac agg acc ttc atc tcc cca gag gag ctc 480 Glu Ala Phe Leu Thr Thr Tyr Arg Thr Phe Ile Ser Pro Glu Glu Leu 145 150 155 160 atc aag aag ctg cag tac aga tat gag aaa ttc tct ccc ttt gcc gac 528 Ile Lys Lys Leu Gln Tyr Arg Tyr Glu Lys Phe Ser Pro Phe Ala Asp 165 170 175 aca ttc aag aag cg gtc agc aag aac acg ttc ttc gtg ctg gta cgg 576 Thr Phe Lys Lys Arg Val Ser Lys Asn Thr Phe Phe Val Leu Val Arg 180 185 190 gtg gtg gat gag ctc tgc ctg gtg gag ttg aca gaa gag atc gaa gag atc 624 Asp Glu Leu Cys Leu Val Glu Leu Thr Glu Glu Ile Leu Lys 195 200 205 ctg ctg atg gaa ctg gtc ttc cgc ctg gtg tgc aat ggg gag ctg agc 672 Leu Leu Met Glu Leu Val Phe Arg Leu Val Cys As r 210 215 220 ctg gcc cgt gtg ctc cgg aag aac atc ctg gac aag gtg gac cag aag 720 Leu Ala Arg Val Leu Arg Lys Asn Ile Leu Asp Lys Val Asp Gln Lys 225 230 235 240 aag cta ctc agg tgtgc acc tcc ag cag ccc ctg gca gcc cgg ggg 768 Lys Leu Leu Arg Cys Ala Thr Ser Ser Gln Pro Leu Ala Ala Arg Gly 245 250 255 gta gca gcc agg ccg ggg acc ttg cac gac ttt cac agc cat gag ata 816 Val Ala Ala Arg Pro Gly Thr Leu His Asp Phe His Ser His Glu Ile 260 265 270 270 gcg gag cag cta acg ctg ctg gat gct gag ctc ttc tat aaa ata gag 864 Ala Glu Gln Leu Thr Leu Leu Asp Ala Glu Leu Phe Tyr Lys Ile Glu 275 280 285 at cct gag gtt ttg ctt tgg gca aaa gag cag aat gag gag aag agc 912 Ile Pro Glu Val Leu Leu Trp Ala Lys Glu Gln Asn Glu Glu Lys Ser 290 295 300 ccc aac ttg acc cag ttc acg gag cac ttc tac aac atg tcc tgg 960 Pro Asn Leu Thr Gln Phe Thr Glu His Phe Asn Asn Met Ser Tyr Trp 305 310 315 320 gtc cgg tcc ata atc atg tta cag gaa aag gcc cag gac agg gaa cgg 1008 Val Arg Ser Ile Ile Met Leu Gln Glu Lys Ala G ln Asp Arg Glu Arg 325 330 335 ctg ctc ttg aag ttc atc aag atc atg aag cac ttg cgg aag ctg aat 1056 Leu Leu Leu Lys Phe Ile Lys Ile Met Lys His Leu Arg Lys Leu Asn 340 345 tac ttc ac gcc atc ctc tct gcc ctg gac tcg gcg ccc 1104 Asn Phe Asn Ser Tyr Leu Ala Ile Leu Ser Ala Leu Asp Ser Ala Pro 355 360 365 atc cgc agg ctg gag tgg cag aag cag act tca gag ggc ctg gcc gag Arg 1152 Leu Glu Trp Gln Lys Gln Thr Ser Glu Gly Leu Ala Glu 370 375 380 tac tgc aca ctg atc gac agc tcg tcc tcc ttc cga gcc tac cgg gcc 1200 Tyr Cys Thr Leu Ile Asp Ser Ser Ser Ser Phe Arg Ala Tyr Arg Ala 385 390 395 400 gcc ctc tcg gag gtg gaa ccg ccg tgc atc ccg tac ctg ggg ctg atc 1248 Ala Leu Ser Glu Val Glu Pro Pro Cys Ile Pro Tyr Leu Gly Leu Ile 405 410 415 ctg cag gac ctg ac ttg gtt cca gac tac atc gac 1296 Leu Gln Asp Leu Thr Phe Val His Leu Gly Asn Pro Asp Tyr Ile Asp 420 425 430 ggg aaa gtg aac ttc tcc aag cgg tgg cag cag ttc aac atc ctc gac 1344 Gly Lys Val Asn Phe Ser Ly s Arg Trp Gln Gln Phe Asn Ile Leu Asp 435 440 445 agc atg cgc tgc ttc cag cag gcg cac tat gac atg cgg agg aac gac 1392 Ser Met Arg Cys Phe Gln Gln Ala His Tyr Asp Met Arg Arg Asn Asp 450 455 att ata aac ttc ttc aat gac ttc agt gac cac ctg gct gag gag 1440 Asp Ile Ile Asn Phe Phe Asn Asp Phe Ser Asp His Leu Ala Glu Glu 465 470 475 480 480 gcc cta tgg gaa ctg tct ctg cc a aaa c aca agg 1488 Ala Leu Trp Glu Leu Ser Leu Lys Ile Lys Pro Arg Asn Ile Thr Arg 485 490 495 aga aaa aca gac cgg gaa gag aag acc taggagcaga cgccgggatc 1535 Arg Lys Thr Asp Arg Glu Glu Lys Thr 500 505 cagggag cgg gag gg cag gag gg cttggacctg 1595 ttaggcgcat ggcaggagtc ccggcctcgg agccatgagg ctggccagcc ctcagcgggg 1655 ccgggcggga gctggagcct gccagccgct tcctgcctcc ttcctctgtg ggagcagacc 1715 cgtgggcctc agggcagcca gcaggggtgc attatttagg aagcagtcaa ggtgtggttc 1775 gggccatctg agtccctcat tggctgccag cagtctgggg gaatatgtcc ttggctgcaa 1835 agggctgtgt cctgactctg cagctgataa gcaaaaggac cctgg aggga gagacaccag 1895 agaccgtgtt gctggaagag gggctctgtg gacccactgg ggcgccagtg gctgcgtgct 1955 aggagaggct gtgcccaggg ccgcccccgc acctacctcg tgggagtaga cgatggcgat 2015 gagaccgatg ggaccaccca gttgcaggaa aacaaactca gggctctcac tgattctaca 2075 tcaaggccgg agtgcagtgg cgtgatcttg gctcactgca agctccacct cccgggttca 2135 caccattctc ctgcctcagc ctcccgagta gctgggaccg cgggcgcccg ccaccatgcc 2195 cggctaattt tttgtatttt tggtggagac ggggtttcgc catgttggcc aggatggtct 2255 cgatctcctg acctcgtgat ccacccgcct cggcctccca aagtgctggg attacaggtg 2315 tgagccaccg cgtccgcccg gggttgtctg ttttgtatat gaaaagcatg ctctgccccg 2375 agccttagct atctctctct cttttttatt tttgagacgg agtcttgctc tgtggcccag 2435 gctggagtgc agtggcacca tctcggctca ctgcaacctc cacctcccgg gttcaagcgg 2495 ttctcctgcc tcagcctccc gagtagctgg gattgcaggc gcccgccacc acgcccagct 2555 gatttgttgc atttttagta gaggcggggt ttcgccgtgt tcgccaggat ggtctcgatt 2615 tcctgacctc gtgatctacc cgcctcggcc tccaaaagtg ttgggattac aggcgtgagc 2675 caccgcgccc ggctggaaat ccataatttc aatggatcag aatttgcctg tcacgttctc 2735 tgtgccaggc acggagcggg ggggcggcag ggatggaacc cggcacatgg gcctctgcct 2795 ccttggcgcg ctgtaggcgc gagcctaaag tcatcaggcg acagcccccg ccacgttccg 2855 gggcgccccg acggctccag cagcgggtgg ggtgggaggc gtccggacag tccggaggcc 2915 tcgatggcca agaggagcct gggctggagg gggccaggcc ccggggcggc cgggggaggg 2975 cccgggactg gcgcagaggc agcgcgaggc agaggcaagc actcggacga aggcgcagcc 3035 ccagcctcgg ggtgcggaac gggcaccttc cgggccactt gagtctgaga ccttgtagcc 3095 ggctcgaggc ccgggcgcag cagtccctgc cagccagctt tcggcgcaat gggacgcggg 3155 cgctcctggt gtgccggcct cgggccctgc accctcacgc atgcgcgccc ccccccggtg 3215 gactacaact cccggcgtgc cccgcgcgcc tcccggaagt gatcgctcca gtcgcctccg 3275 acctcggcgc tgggcgggcg cgccgggcct ggggaagggg cgggcgcggg gacccgatgc 3335 gcgggagcgg aggccgagat ggcttcggcg ggaggcgaag actgcgagag ccccgcgccg 3395 gaggccgacc gtccgcacca gcggcccttc ctgatagggg tgagcggcgg cactgccagc 3455 gggaagtcga ccgtgtgtga gaagatcatg gagttgctgg gacagaacga ggtggaacag 3515 cggcagcgga aggtggtcat cctgagccag gacaggttct acaaggtcct gacgg cagag 3575 cagaaggcca aggccttgaa aggacagtac aattttgacc atccagatgc ctttgataat 3635 gatttgatgc acaggactct gaagaacatc gtggagggca aaacggtgga ggtgccgacc 3695 tatgattttg tgacacactc aaggttacca gagaccacgg tggtctaccc tgcggacgtg 3755 gttctgtttg agggcatctt ggtgttctac agccaggaga tccgggacat gttccacctg 3815 cgcctcttcg tggacaccga ctccgacgtc aggctgtctc gaagagttct ccgggacgtg 3875 cgccgaggga gggacctgga gcagattctg acgcagtaca ccaccttcgt gaagccggcc 3935 ttcgaggagt tctgcctgcc gacaaagaag tatgccgatg tgatcatccc acgaggagtg 3995 gacaatatgg ttgccatcaa cctgatcgtg cagcacatcc aggacattct gaatggtgac 4055 atctgcaaat ggcaccgagg agggtccaat gggcggagct acaagcggac cttttctgag 4115 ccaggggacc accctgggat gctgacctct ggcaaacggt cacatttgga gtccagcagc 4175 agaccccact gaggggctgc cgagcctcag ggcaggtctc ccgcccggca tgtgtgttca 4235 gggactgagc ctggggacgc ccacccacac ccactgcttc ctctcggcgc accccagggg 4295 agtgttagca gcgaggcctt cctcactcag gagtggaaac tcagatgtgt cactcagact 4355 caacttgctg ggacactgac aggcgttcct gaggttttca gccacttagg ctcgttgcgg 4415 tttaaagatc cctctaggtc actgagaaat gccacagaat gtgcaggaag cctgggaggc 4475 ttctgtgagg aatgtgaggc acattattgg ggaaattgag gagacagcct agacactggc 4535 tggcctgatg ttttgttgac agtgaaccca cagtgggaga gagttttttc cagtctgatc 4595 tggttcttac acacacacat aactcaaaag ttttgtgaac aagtactttc cttttttaca 4655 tgttacatgt cctcatgttt tctgttttct gtttcataac acaaggctgg ttgtggccta 4715 caaacctaat ttcatgaccc agtggtttgc agtccagcgt ggcctacacg gatatgggga 4775 gccactgagg gatgttttcc ccccttgctt gtgccttaaa ggcagagaag cgaggcggat 4835 gccctggaag cacccagcat cacacccagg cttgtgcggg gccaggctgg gagcccatgc 4895 agtagggcag aaggcagcgg aggccaggtc tgtcccggct ggagaacagc gtccacgcag 4955 tcctgcctgg ggtcaggccc tcactgaccc tcaggggagc ccccaaggtg ctgtctgtct 5015 agacaggctg tcccacccca gggtggctag tggccatatg cagggaatgg tgcttctggc 5075 tgtggcacgc actggatcac ccaggtccca gcagacatgg ccgcccaaag tcagcaagcc 5135 tcctttgtgc tatgtggagc tcacagcctc acatgtgaac acccgtgtct gggttgcctg 5195 gggtgatcct ccctcctgcg tggtggctgt ctctggaaag catcccttgc cgctgccacg 5255 ggcagcccca gcccccgtcc gtccaggctc acccacagta gtgatgcaga cgtgacgtgg 5315 gggaaggggg ctgagccctg tggctgggtt ctgacaactg taacggtttt gtcgagctta 5375 ggcccctttg gagggagaat caataaataacaataa <210> 42 <211> 4834 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2205) <400> 42 ttc ttt act aac cct aca aaa aac cta gtg tct ata act aaa gat tct 48 Phe Phe Thr Asn Pro Thr Lys Asn Leu Val Ser Ile Thr Lys Asp Ser 1 5 10 15 gaa ctg ccc acc tgc agc tgt ctt gat cga gtt ata caa aaa gac aaa 96 Glu Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp Lys 20 25 30 ggc cca tat tat aca cac ctt ggg gca gga cca agt gtt gct gct gtc 144 Gly Pro Tyr Tyr Thr His His Leu Gly Ala Gly Pro Ser Val Ala Ala Val 35 40 45 agg gaa atc atg gag aat agg tat ggt caa aaa gga aac gca ata agg 192 Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile Arg 50 55 60 ata gaa ata gta gtg tac acc ggt aaa gaa ggg aaa agc tct cat ggg 240 Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His Gly 65 70 75 80 tgt cca att gct aag tgg gtt tta aga aga agc agt gat gaa gaa aaa 288 Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu Lys 85 90 95 gtt ctt tgt ttg gtc cgg cag cgt aca ggc cac cac tgt cca act gct 336 Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr Ala 100 105 110 gtg atg gtg gtg ctc atc atg gtg tgg gat ggc atc cct ctt cca atg 384 Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro Met 115 120 125 gcc gac cgg cta tac aca gag ctc aca gag aat cta aca tca tac aat 432 Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr Asn 130 135 140 ggg cac cct acc gac aga aga tgc acc ctc aat gaa aat cgt acc tgt 480 Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr Cys 145 150 155 160 aca tgt caa gga att gat cca gag act tgt gga gct tca ttc tct ttt 528 Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser Phe 165 170 175 ggc tgt tca tgg agt atg tac ttt aat ggc tgt aag ttt ggt aga agc 576 Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg Ser 180 185 190 cca agc ccc aga aga ttt aga att gat cca agc tct ccc tta cat gaa 624 Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His Glu 195 200 205 aaa aac ctt gaa gat aac tta cag agt ttg gct aca cga tta gct cca 672 Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala Pr o 210 215 220 att tat aag cag tat gct cca gta gct tac caa aat cag gtg gaa tat 720 Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu Tyr 225 230 235 240 gaa aat gtt gcc cga gaa tgt cgg ctt ggc agc aag gaa ggt cgt ccc 768 Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg Pro 245 250 255 ttc tct ggg gtc act gct tgc ctg gac ttc tgt gct cat ccc cac agg 816 Phe Ser Gly Val Thr Cys Leu Asp Phe Cys Ala His Pro His Arg 260 265 270 gac att cac aac atg aat aat gga agc act gtg gtt tgt acc tta act 864 Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu Thr 275 280 285 cga gaa gat aac cgc tct ttg ggt gtt att cct caa gat gag cag ctc 912 Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln Leu 290 295 300 cat gtg cta cct ctt tat aag ctt tca gac aca gat gag ttt tcc 960 His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly Ser 305 310 315 320 aag gaa gga atg gaa gcc aag atc aaa tct ggg gcc atc gag gtc ctg 1008 Lys Glu Gly Met Glu Ala Lys Ile Lys Ser GlyAla Ile Glu Val Leu 325 330 335 gca ccc cgc cgc aaa aaa aga acg tgt ttc act cag cct gtt ccc cgt 1056 Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro Arg 340 345 350 tct gga aag aag agg gct gcg atg atg aca gag gtt ctt gca cat aag 1104 Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His Lys 355 360 365 ata agg gca gtg gaa aag aaa cct att ccc cga atc aag cgg aag aat 1152 Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys Asn 370 375 380 aac tca aca aca aca aac aac agt aag cct tcg tca ctg cca acc tta 1200 Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr Leu 385 390 395 400 ggg agt aac act gag acc gtg caa cct gaa gta aaa agt gaa acc gaa 1248 Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr Glu 405 410 415 ccc cat ttt atc tta aaa agt tca gac aac act aaa act tat tcg ctg 1296 Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser Leu 420 425 430 atg cca tcc gct cct cac cca gtg aaa gag gca tct cca ggc ttc tcc 1344 Met Pro Ser Ala Pro His P ro Val Lys Glu Ala Ser Pro Gly Phe Ser 435 440 445 tgg tcc ccg aag act gct tca gcc aca cca gct cca ctg aag aat gac 1392 Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn Asp 450 455 460 gca aca gcc tca tgc ggg ttt tca gaa aga agc agc act ccc cac tgt 1440 Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His Cys 465 470 475 475 480 acg atg cct tcg gga aga ctc agt ggt gcc aat gca gct gct gct gat 1488 Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala Asp 485 490 495 ggc cct ggc att tca cag ctt ggc gaa gtg gct cct ctc ccc acc ctg 1536 Gly Pro Gly Ile Ser Gln Leu Gly Glu A Val Pro Leu Pro Thr Leu 500 505 510 tct gct cct gtg atg gag ccc ctc att aat tct gag cct tcc act ggt 1584 Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr Gly 515 520 525 gtg act gag ccg cta acg cct cat cag cca aac cac cag ccc tcc ttc 1632 Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser Phe 530 535 540 ctc acc tct cct caa gac ctt gcc tct tct cca atg gaa gaa gat gag 1680 Leu T hr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp Glu 545 550 555 560 cag cat tct gaa gca gat gag cct cca tca gac gaa ccc cta tct gat 1728 Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser Asp 565 570 575 gac ccc ctg tca cct gct gag gag aaa ttg ccc cac att gat gag tat 1776 Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu Tyr 580 585 590 590 tgg tca gac agt gag cac atc ttt ttg gat gca aat att ggt ggg gtg 1824 Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly Val 595 600 605 gcc atc gca cct gct cac ggc tcg gtt ttg att gag tgt gcc cgg cga 1872 Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg Arg 610 615 620 gag ctg cac gct acc act cct gtt gag cac ccc aac cgt aat cat cca 1920 Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His Pro 625 630 635 640 acc cgc ctc tcc ctt gtc ttt tac cag cac aaa aac cta aat aag ccc 1968 Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys Pro 645 650 655 caa cat ggt ttt gaa cta aac aag att aag ttt gag gct aaa gaa gct 2016 Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu Ala 660 665 670 aag aat aag aaa atg aag gcc tca gag caa aaa gac cag gca gct aat 2064 Lys Asn Lys Lys Met Lys Ala Ser Glu Lys Asp Gln Ala Ala Asn 675 680 685 gaa ggt cca gaa cag tcc tct gaa gta aat gaa ttg aac caa att cct 2112 Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile Pro 690 695 700 tct cat aaa gca tta aca tta acc cat gac aat gtt gtc acc gtg tcc 2160 Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val Ser 705 710 715 720 cct tat gct ctc aca cac gtt gcg ggg ccc tat aac cat tgg gtc 2205 Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 725 730 735 tgaaggcttt tctccccctc ttaatgcctt tgctagtgca gtgtattttt tcaaggtgct 2265 gttaaaagaa agtcatgttg tcgtttacta tcttcatctc acccatttca agtctgaggt 2325 aaaaaaataa taatgataac aaaacggggt gggtattctt aactgtgact atattttgac 2385 aattggtaga aggtgcacat tttaagcaaa aataaaagtt ttatagtttt aaatacataa 2445 agaaatgttt cagttaggca ttaaccttga tagaatcact c agtttggtg ctttaaatta 2505 agtctgttta ctatgaaaca agagtcattt ttagaggatt ttaacaggtt catgttctat 2565 gatgtaaaat caagacacac agtgttaact ctacacagct tctggtgctt aaccacatcc 2625 acacagttaa aaataagctg aattattatt tcatggtgcc attgttccaa catcttccaa 2685 tcattgctag aaaattggca tattcctttg aaataaactt atgaaatgtt ttctctctta 2745 aaatatttct cctgtgtaaa ataaatcatt gttgttagta atggttggag gctgttcata 2805 aattgtaaat atatatttta aaagcacttt ctatttttaa aagtaacttg aaataatata 2865 gtataagaat cctattgtct attgtttgtg catatttgca tacaagagaa atcatttatc 2925 cttgctgtgt agagttccat cttgttaact gcagtatgta ttctaatcat gtatatggtt 2985 tgtgttcttt tactgtgtcc tctcacattc aagtattagc aacttgcagt atataaaata 3045 gttagataat gagaagttgt taattatctc taaaattgga attaggaagc atatcaccaa 3105 tactgattaa cattctcttt ggaactaggt aagagtggtc tcttcttatt gaacaacctc 3165 aatttagttt catcccacct ttctcagtat aatccatgag aggtgtttcc aaaaggagat 3225 gagggaacag gataggtttc agaagagtca aatgcttcta atgtctcaag gtgataaaat 3285 acaaaaacta agtagacaga tatttgtact gaagtctgat acagaat tag aaaaaaaaaa 3345 ttcttgttga aatattttga aaacaaattc cctactatca tcacatgcct ccccaacccc 3405 aagtcaaaaa caagaggaat ggtactacaa acatggcttt gtccattaag agctaattca 3465 tttgtttatc ttagcatact agatttggga aaatgataac tcatcttttc tgataattgc 3525 ctatgttcta ggtaacagga aaacaggcat taagtttatt ttagtcttcc cattttcttc 3585 ctattacttt attgactcat tttattgcaa aacaaaaagg attacccaaa caacatgttt 3645 cgaacaagga gaattttcaa tgaaatactt gattctgtta aaatgcagag gtgctataac 3705 attcaaagtg tcagattcct tgggagtatg gaaaacctaa tggtgcttct cccttggaaa 3765 tgccatagga agcccacaac cgctaacact tacaattttg gtgcaaaagc aaacagttcc 3825 agcaggctct ctaaagaaaa actcattgta acttattaat aatatctggt gcaaagtatc 3885 tgttttgagc ttttgactaa tccaagtaaa ggaatatgaa gggattgtaa aaaacaaaat 3945 gtccattgat agaccatcgt gtacaagtag atttctgctt gttgaatatg taaaataggg 4005 taattcattg acttgtttta gtattttgtg tgcctaaggt ttcttatata catataagta 4065 tataaataag tgattgttta ttgcttcagc tgcttcaaca agatatttac tagtattaga 4125 ctatcaggaa tacacccttg cgagattatg ttttagattt taggccttag c tcccactag 4185 aaattatttc ttcaccagat ttaatggata aagttttatg gctctttatg catccactca 4245 tctactcatt cttcgagtct acacttattg aatgcctgca aaatctaagt atcactttta 4305 tttttctttg gatcaccacc tatgacatag taaacttgaa gaataaaaac taccctcaga 4365 aatattttta aaagaagtag caaattatct tcagtataat ccatggtaat gtatgcagta 4425 attcaaattg atctctctct caataggttt cttaacaatc taaacttgaa acatcaatgt 4485 taatttttgg aactattggg atttgtgacg cttgttgcag tttaccaaaa caagtatttg 4545 aaaatatata gtatcaactg aaatgtttcc attccgttgt tgtagttaac atcatgaatg 4605 gacttcttaa gctgattacc ccactgtggg aaccaaattg gattcctact ttgttggact 4665 ctctttcctg attttaacaa tttaccatcc cattctctgc cctgtgattt tttttattagg 4725 cttattcaat gttctgcagc attgtgat g tatgctgat g tatgctgat g tatgctgat g tatgctgat g tatgctgat <210> 43 <211> 5481 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2021) .. (2767) <400> 43 cctgccacca ggtagaagct ggtggagcct caatcctggc cacggcagcc aacctcctgc 60 gccactaccc cacagaggaa gaggagcagg cgctggagct gctctcagag atggaagaga 120 acgagcccta cccggcggaa tatgaggtca tcaaccagtt ccagccaccc cctgcttaca 180 caccctaatg ccagccctgg gctctcttcc tcggcagccc ctccctcaac tctgcagctc 240 ctctcgcacc cagaggagct cctttcccca gcaggcctca ctggtaggat cctgaccatc 300 ttctccaaac cttccccagg agagactctg cctttagggt catccaagta tccctgctct 360 cagaaccgga ggtccactgg ttttctataa tgtactcttt ccctcctgcc acatcctgcc 420 cccttcacat tcacgagtca ttaccagcca gggaaggtca tccaagtttc ctccagcatg 480 ggcgatatct ttgggaccga gactttcctt ggagagctgc tgagagcgga cagtcccaaa 540 aacaagtgtc aaagggccca agggaaaggg gactgtgccc tggaggctca cttcacaggg 600 atcagtgttt gctccacagc tgtagctctg ggctgacgcc ccccagaccc cttccttctc 660 ggagtgaccc gcccccaggc cacctgctcc ggggagttct gtgcacttta ctctttggac 720 ttctcctcac gtgtgccctg gttttatggg gagagggaat cgctgttggg aaggcagagc 780 agttgcaacc ctctctgccc ttgcttcatg tggctggagc ccaggcaagg agagcaggag 840 ccagcgtgag a ctgaggccc cctggtgcct atcaaggacc agagtgaagg ggactacatc 900 tcccagccct tcacctttta aatatgagtg gttttaaaag gaaaaaaatg aaaccaggca 960 acagcaacaa tattctgttt ttaaaatagg gacaagactg ttgtcacttt ttagacatgt 1020 atcccattcc ttttggctct gcaatatttg gggctgtagc tccttccaag cccatggtag 1080 tccctccccg agtctctccc agtagaatgc agcctccctt ccctggcccc ttccctctca 1140 gtgacggtga ctccctgggg ccttctcgtg gaacccagag gggctgagga ctgtggcctg 1200 gctggcgggc cagcgtggtg ctcctcagga ctgcagcact gagatggaac ctggcctcag 1260 tttaggaaca ggggccacaa cagggcagga acccaccacc ctccacatag gaatacaacc 1320 agtggggcca catcatgtga ggcatcagac ccacactgtc agcccagcag gccgggctgt 1380 gtccttcaga cccagtgctg ccctagactc tgactcggga ctccagcttg ccacgtgccc 1440 tctcccctct tgaatgtact ctggtcttgc agtgtgctgc tgggactttc ttgctcagcc 1500 atcactctgg tcaccttgtt tgctctgggt ctggctgaat tttctgccct gagatctggg 1560 cataaagtgg atgaaacttg aaagaccttc agtgtagatc cagatggcca acctgtcctt 1620 gttaagttac ttgcttcttg ggaatcagtg tcccctgctg agctgaaaag gaaatggatt 1680 ccaatctctt ccaacctt ta aggtgataga tagtttgagc aagactggag aatggacaac 1740 actatgaagc tgtggctaga aagggactgt catgtcccat cctttggcca gattgactgg 1800 ggatgtccgg acagatgcct gcatgggtgg tgagggccac atctgcacac gagccagtgg 1860 ctgcttgcag ttcactgctg tgatgccaga gtgtgttcaa aggtgactct cctgctcttc 1920 tggactcttc tctcaggcaa gaaaggctgc aggctgcctg ctatgtgatg cctgagcaca 1980 aagccaagga actgaactaa gtctttctgt taagtcctga gtt tgt cat tgg cag 2035 Val Cys His Trp Gln 1 5 gtt tac ttg tgg cca gct ctc tct gcc ctt ggg tgt ctg agc agg cag 2083 Val Tyr Leu Trp Pro Ala Leu Ser Ala Leu Gly Cys Leu Ser Arg Gln 10 15 20 acc aga aga cca ggc act gga cct gca tgc caa agg gac tgg tca tct 2131 Thr Arg Arg Pro Gly Thr Gly Pro Ala Cys Gln Arg Asp Trp Ser Ser 25 30 35 cct gag gac ctg tac atg acc ctg tgg act gtt ccg cac gat ccg gaa 2179 Pro Glu Asp Leu Tyr Met Thr Leu Trp Thr Val Pro His Asp Pro Glu 40 45 50 ccc act ttt tat tca ctc ccc atg tct ttg gcc ttc ctc ttc ttt ctc 2227 Pro Thr Phe Tyr Ser Leu Pro Met Ser Leu Ala Phe Leu Phe Phe Leu 55 60 65 ttt ccc tct gcc atc ctg aca ctg ata gtt tgt cat ata aat tcc ccg 2275 Phe Pro Ser Ala Ile Leu Thr Leu Ile Val Cys His Ile Asn Ser Pro 70 75 80 85 ggt tgt gtt ttt ttt tct aga aaa aaa tta aaa ggg aaa aca aaa cca 2323 Gly Cys Val Phe Phe Ser Arg Lys Lys Leu Lys Gly Lys Thr Lys Pro 90 95 100 aaa aaa cca gaa acc acg aat aag aat gga aat gac aat ggc tgc ctg 2371 Lys Lys Pro Glu Thr Thr Asn Lys Asn Gly Asn Asp Asn Gly Cys Leu 105 110 115 tca ttt ttc tgt cac gat ttt cct gat ttg gtt tgt tcc ctt tgt ctc 2419 Ser Phe Phe Cys His Asp Phe Pro Asp Leu Val Cys Ser Leu Cys Leu 120 125 130 aga gaa gca gga gat gtt gat gag gct gta ttt ttt ttt ctt ttt ctt 2467 Arg Glu Ala Gly Asp Val Asp Glu Ala Val Phe Phe Phe Leu Phe Leu 135 140 145 gtt ttt gag aca aga gtc tcg ctc tgt cac ccg ggc tgg agt gta Gglu Ghe Pg Thr Arg Val Ser Leu Cys His Pro Gly Trp Ser Val Thr 150 155 160 165 tgg cat gat ctc agc tca ctg caa cct ctg cct cct ggg ttc aag cga 2563 Trp His Asp Leu Ser Ser Leu Gln Pro Leu Pro Pro Gly Phe Lys A rg 170 175 180 tta tcc tgc ctc agc ctc ctg agt agc tgg gat tac agg cat gcg cca 2611 Leu Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp Tyr Arg His Ala Pro 185 190 195 cta tgc cca gat aat ttt tt gta ttt gta gag aca ggg ttt cac 2659 Leu Cys Pro Asp Asn Phe Phe Val Phe Leu Val Glu Thr Gly Phe His 200 205 210 cat gtt ggc cag gct ggt ctg gaa ctc cta acc tca ggt tat cca ccc 2707 His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Tyr Pro Pro 215 220 225 acc ttg gcc tcc caa agt gct ggg att ata ggc atg aac cac cgt gcc 2755 Thr Leu Ala Ser Gln Ser Ala Gly Ile Ile Gly Met Asn His Arg Ala 230 235 240 245 tgg cca aag atg taatttaaaa tagttagaag ggacttggca tgggccagct 2807 Trp Pro Lys Met ccgtgcatgg cattttcacc cccagagctt cctaatcctg ttttcacaca ggaagtttct 2867 aggtctttct agaacagcta gaaatagtag ctgactcccg cccaaggccc aaccttcaaa 2927 ccctgagctc ttcaggctgc atcctctggt gagctataga ggagaacgtg gctcctaaac 2987 tctagccatc ctgtgggagg aaatagactt ctttgggctg tggcttgcag aacaaactac 3047 actttttttc cctctattgt ttaaatttta ttt aataatt tgtgtgtttt tctgtcttta 3107 ttttctgtat ttcacgtgtt ccttcactcc ctagaaactg cactttcttt gaaaccatag 3167 gtaatgaatc ttactaggag aggcatgggg atagagacag ttctgggagt gtgacctgta 3227 agcctcctgt agggcagtgc caggccttga ttgcccacgt tctctccgtt ccttcttcct 3287 tcatacattt gatcacacag cctacaccca gccccgagtg tgcatcacgg taaaagagct 3347 gagggctctc ttcagggagc agcccattta ggtctctttt gttgttgtta gggagaatac 3407 acatctttct tggaagctgg gagtgtgttc tcatttcatg tccattcaga caaagcacca 3467 ttaggcacca tgaaatatac agtgacggac aggaccctgt ctgcaaggat tttatgtcct 3527 tagttcagga gatggacttg tccacagaaa ggcagagtga agtgggcggc cggctcggaa 3587 aagtcctgtg cccagaaggg agccagttct gacctgagtg ataatgaaag gcttcctgga 3647 ggacgcagct tgagccacac ttgatgtggg agtgaactgg gatagggaca ctcctgctga 3707 gagaatggca agagcaaaag cacactggtg gccaggaggt ggtaagagcc gaggttagaa 3767 aggtgagggg tgctcattta aggcactaac agcagaagga gcccaggaag gattttcaga 3827 agggaaggga gggatgcaac cttattttaa tgactggtga cagtaggaag ggttctgcct 3887 ggccttaagt gagggtgttg aaagtgggag acaggacc tg ccaaagggga agagggcggt 3947 cacagtcaat cccagggccc agtgtctcag ccaggtgctg gagttgggaa tgcgggagcc 4007 ccagtctctg cccacctgtc acgtggcagc tggaaggtgg catcaactgc acaggcgaag 4067 aggggcccgc acacgagaag ccatgggatg tgaagggccg caaggagagg accctgggac 4127 acaggaagag gtggtgcatc tggggcaggg cggctttccc aagatgacta gagaatcttc 4187 agctggcatc ttgcctgaaa tatccacgct ctcagccact acactaatgg aacacagatg 4247 ctatggggag acagaaggga actgacaaac ttcatgcccc tgttttcaaa tagcctgcaa 4307 tcttacctct tcctctgcat tttttggggg gagtgacatt ttaatgggag gcaggaggtt 4367 tgtggagaag agaaaatgtt ttttttgtgg gggtgggtag agacagtctc accatgttgc 4427 ccaggctggt ctcaaactac tggcttcagg caatccttct gcctcccttc ccaaagggtt 4487 gggattacag gcttgagcca ctgcaccaag cctgaaaatg tcgttttgaa tgagcccacc 4547 tgaaacgaag acgcttcatt agggttactg gtttgagaat taagatcagt tctggccggg 4607 tgcggtggct cacgcctatt atcccagcac tttgggaggc cgaggtgggt ggatcacaag 4667 gtcaggagat cgagaccatt ctggccaaca tggtgaaacc ccgtctctac taaaaataca 4727 aaaattaacc aggcatggtg gcaggtgcct gtagtcccag cta ctcggga ggctgaggca 4787 ggagaatcac ttgaacccgg gaggcagagg ttgcagtgag ccgagatcat gccactggac 4847 tccagcctga cagagtgaga ctccatctca aacacacaca cacacacaca cacacaccac 4907 acacacacac acaggttcct caccataagc tttggggaaa attcttggct tttttgctgg 4967 gggagagagc agtgcccagg gaagattggc tgatctcaga gctggagggt ttatgcggga 5027 ctggccagcc ccttcagctg agtgggacag caacacagtg ggtggtaagg ggcttcataa 5087 gatgtacaag atgagggaga ggcccctcca gccaaccctg tgtctaaaga gtcaggtaac 5147 gaagaacttt ccagagacag ctgtgagtcc gtctggctta aggggttgta caggtgtctg 5207 agaatggggc ctgaaggtgc agggcctgca ggctgccctg tttggaaggt tcctgtcctt 5267 ctgtcttggt agaaaatggc agctagcctt gtaaagggcc tccttgtgta gcgagataga 5327 ccatgtagcc ccagatgccc ccatggcttc acttccctct tgggggtctc tcagtatatg 5387 tctagtgcca ccactattgg tggagagttt ccttctggaa taaccttggg gtggtggatg 5447 ggttttattt taataaaaga agaatgtctc attc 5481 <210> 44 <211> 5429 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1381) .. (3096) <400> 44 tcgcgatcta gaactagtgc cctgtctcta ctgaaaatac agaaggattg gctggacatg 60 gtggtgggtg cctgtggtcc cggctgctcg ggaggctgag gcaggagaat gacatgggcc 120 ttggaggcgg agcttgcagt gagcccagat ggcgccactg tgctccagcc tgggcgactg 180 agcgaggctc cgtctcaaaa aaaaaaaatt ctttcattta tttagttact tttagagata 240 gagcctcccg ctgttgccca ggctggagtg cagtggcagt catggcttac tgcagctttg 300 aactcctggg ctcaaatgat cctcctgtct cagcctctcc agtagctggg actgactgca 360 ggcacgtgcc accacaccca gctaattttt atttttattt ttattttttt gagacagggt 420 tttactctgt cacccaggct agagtgcagt ggtgagatca tggctcactg tagcctctgt 480 ctccggggct caatcaatcc tcccacctca gcctccccag tggctgggat tactggtgca 540 caccaccata ccctgctaat tgtatttatt tttagtagag atgggatttt gccatgttgc 600 ccagactggt cttgagctgc tgggctcaag cgatcttccc atcacagctt cccaatgtgc 660 tgggattaca ggtgtgagcc actgtacctg gccagcttta cttcttttac cagcactcct 720 gattttataa atagtgaggc ttatcaaccc catttctacc caaatcttct ggtagacttg 780 agtatagtag ggcttcatag gtagcagccc tgtccctgtc ctattatgat ggtagctgtt 840 gtgatgtggc gatctctgat ctagaaaccc ctgaggggcc attgtggcct gcccagtctc 900 ccggccacgg ttgaaaccag acgtgcagtg gggctgaccc ctgtgcccca ccccagagtc 960 atgccagcgt gggtggtggg gcattctctg ggatgaatga tctggatccc atagccatct 1020 gtgtcctgtt tgaggaatgg gaccctcaaa cagagaacag ccaagatgct caagcaggtg 1080 tgtgcttggg ccagactctg cagcctttgg tttgggactt gactgccatt cactgaaggg 1140 gcccaggaaa tgggcagctc acatggtgtt gctgggtgtc cagctgcggc agtttagcag 1200 aggaggactt gtaatgagat ggtagcttct tataggctaa gacatgattt ttctgttctt 1260 ttactacctc ctgcaccttc tagaactgtt ccttcctgat gctgttttcc tttcttccag 1320 tggtttatct ctagggtctc catagcaggg gaggtagggt cagactcctg agatggctga 1380 tgt cct acc ctg ccc cca acc agg ggc ccc agg aga ctc ctt ttt Arg Pro Cyg Pro 14G gca act ttg gcc tcc tca gtc tgc aga tct cca ggg gag ccc acc 1476 Thr Ala Thr Leu Ala Ser Ser Val Cys Arg Ser Pro Gly Glu Pro Thr 20 25 30 agc cta gtc aac atg gcc tcg gaa gac att gcc aag ctg gca gag aca 1524 Ser Leu Val Asn Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr 35 40 45 ctt gcc aag act cag gtg gcc ggg gga cag ctg agt ttc aaa ggc aag 1572 Leu Ala Lys Thr Gln Val Ala Gly Gly Gly Gln Leu Ser Phe Lys Gly Lys 50 55 60 agc ctc aaa ctc aac act gca gaa gat gct aaa gat gtg att aaa gag 1620 Ser Leu Lys Leu Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu 65 70 75 80 att gaa gac ttt gac agc ttg gag gct ctg cgt ggc aac aca 1668 Ile Glu Asp Phe Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr 85 90 95 gtg ggc gtg gaa gca gcc agg gtc atc gcc aag gcc tta gag aag aag 1716 Val Gly Val Glu Ala Ala Arg Val Ile Lys Ala Leu Glu Lys Lys 100 105 110 tcg gag ttg aag cgc tgc cac tgg agt gac atg ttc acg gga agg ctg 1764 Ser Glu Leu Lys Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu 115 120 125 cgg acc gag atc cca cca gcc ctg atc tca cta ggg gaa gga ctc atc 1812 Arg Thr Glu Ile Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile 130 135 140 aca gct ggg gct cag ctg gtg gag ctg gac tta agc gac aac gca ttc 1860 Gly A la Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe 145 150 155 160 ggg ccc gac ggt gtg caa ggc ttc gag gcc ctg ctc aag ag agc tca gcc 1908 Gly Pro Asp Gly Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ala 165 170 175 tgc ttc acc ctg cag gaa ctc aag ctc aac aac tgt ggc atg ggc att 1956 Cys Phe Thr Leu Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly Ile 180 185 190 ggc ggc ggc ag atc gct gaa tgt cac cgg aaa 2004 Gly Gly Gly Lys Ile Leu Ala Ala Ala Leu Thr Glu Cys His Arg Lys 195 200 205 tcc agt gcc caa ggc aag cct ctg gcc ctg aag gtc ttt gtg gct ggc 2052 Ser Ser Ala Gln Gly Lys Ala Leu Lys Val Phe Val Ala Gly 210 215 220 aga aac cgt ctg gag aat gat ggc gcc act gcc ttg gca gaa gct ttt 2100 Arg Asn Arg Leu Glu Asn Asp Gly Ala Thr Ala Leu Ala Glu Ala Phe 225 230 235 240 agg gtc atc ggg acc ctg gag gag gtc cac atg cca cag aat ggg atc 2148 Arg Val Ile Gly Thr Leu Glu Glu Val His Met Pro Gln Asn Gly Ile 245 250 255 aac cac cct ggc atc act gcc ctg gcc cag gct ttc gct gtc aac ccc 2196 Asn His Pro Gly Ile Thr Ala Leu Ala Gln Ala Phe Ala Val Asn Pro 260 265 270 ctg ctg cgg gtc atc aac ctg aat gac aac acc ttc act gag aag ggc 2244 Leu Leu Arg Val Ile Asn Leu Asn Asp Asn Thr Phe Thr Glu Lys Gly 275 280 285 gcc gtg gcc atg gcc gag acc ttg aag acc ttg cgg cag gtg gag gtg 2292 Ala Val Ala Met Ala Glu Thr Leu Lys Thr Leu Arg Gln Val Glu Val 290 295 300 att aat ttt ggg gac tgc ct gtg cgc tcc aag ggt gca gtt gcc att 2340 Ile Asn Phe Gly Asp Cys Leu Val Arg Ser Lys Gly Ala Val Ala Ile 305 310 315 320 gca gat gcc atc cgc ggt ggc ctg ccc aag cta aag gag ctg aac Astgla A388 Ile Arg Gly Gly Leu Pro Lys Leu Lys Glu Leu Asn Leu 325 330 335 tca ttc tgt gaa atc aag agg gat gct gcc ctg gct gtt gct gag gcc 2436 Ser Phe Cys Glu Ile Lys Arg Asp Ala Ala Leu Ala Val Ala Glu Ala 345 350 atg gca gac aaa gct gag ctg gag aag ctg gac ctg aat ggc aac acc 2484 Met Ala Asp Lys Ala Glu Leu Glu Lys Leu Asp Leu Asn Gly Asn Thr 355 360 365 ctg gga gaa gaa ggc tgt cagac ctt gag gtg ctg gag ggc ttc 2532 Leu Gly Glu Glu Gly Cys Glu Gln Leu Gln Glu Val Leu Glu Gly Phe 370 375 380 aac atg gcc aag gtg ctg gcg tcc ctc agt gat gac gag gac gag gag 2580 Asn Met Ag Ala Aet Ala Ser Leu Ser Asp Asp Glu Asp Glu Glu 385 390 395 400 gag gag gag gaa gga gaa gag gaa gaa gag gaa gca gaa gaa gag gag 2628 Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu 405 gaa gat gag gaa gag gag gaa gaa gag gag gag gag gag gaa gaa 2676 Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 420 425 430 gag cct cag cag cga ggg cag gga gag agcc tg cgg 2724 Glu Pro Gln Gln Arg Gly Gln Gly Glu Lys Ser Ala Thr Pro Ser Arg 435 440 445 aag att ctg gac cct aac act ggg gag cca gct ccc gtg ctg tcc tcc 2772 Lys Ile Leu Asp Pro Asn Thr Gly Glu Pro Ala Pro Val Leu Ser Ser 450 455 460 cca cct cct gca gac gtc tcc acc ttc ctg gct ttt ccc tct cca gag 2820 Pro Pro Pro Ala Asp Val Ser Thr Phe Leu Ala Phe Pro Ser Pro Glu 465 470 475 480 480 aag ctg ctg cgc cta ggg ccc aag agc tcc gtg ctg ata gcc cag cag 2868 Lys Leu Leu Arg Leu Gly Pro Lys Ser Ser Val Leu Ile Ala Gln Gln 485 490 495 act gac acg tct gac ccc gag aag gtg gtc tct gcc ttc c16 aag gt Asp Thr Ser Asp Pro Glu Lys Val Val Ser Ala Phe Leu Lys Val 500 505 510 tca tct gtg ttc aag gac gaa gct act gtg agg atg gca gtg cag gat 2964 Ser Ser Val Phe Lys Asp Glu Ala Thr Val Arg Met Ala Val Gln Asp 515 520 525 gca gta ggt aat gtg ggc tgg gtg aga cct ggg tgc cct ctg tcc ctt 3012 Ala Val Gly Asn Val Gly Trp Val Arg Pro Gly Cys Pro Leu Ser Leu 530 535 540 gat gct cgt ggg ccc cag gtag tcctt gtt gcc gta act cgt cag 3060 Asp Ala Arg Gly Pro Gln Val Ser Phe Val Val Ala Val Thr Arg Gln 545 550 555 560 ccc cag cgc tct cat ggg aac tgc tct ttg gcc acc tgagtttttc 3106 Pro Gln Arg Ser His Gly Asn Cys Ser Leu Ala Thr 565 570 ctccgtcagg gtcctgccgt ggagccagct ggctgctctt ctccctgttt ttcaccactg 3166 agaaactgag gcctttccca aatccacaca gccatgtaca gttagaaccc atagcccgct 3226 ctaggaagtc cagatagcca cat ctgcaag cccaatggac gcaggtctat cgggaggagg 3286 gatggtgaga gccaagccct tgtccacacc ttggagcttc tgtgctcacg tccactctac 3346 ctggaggttc cttgcacaga ggacaccttt ccccataaca ttatgggggc ttccttggag 3406 caccagccca tatccctcca gccctatcac aaccctctcc ccaccctgtc tgtttcctcc 3466 attccagcac ctgtcacctt ccaccctgtt tccatgtgct tgactgagcc tccacatcta 3526 acgaaacctg agccagttcc ggttaggcag aggggaggaa gggccctgag gcgaggggga 3586 cggttcctgg aaaagataga aaggggtgga aggacatgtg gtgcctcttc ccggcgtggc 3646 gtcgaagcgg ggagggcggc tcagtgggaa atgaggctcg gaaggaggtg ggggccagac 3706 acaagcctgc tccctgaggg cccgcctgtg ggcatttttg ggaacaagtt gccctagttc 3766 tgtttcccag gaagcctagc acagtccctg cacatcccct caccctgcca aaataacctg 3826 aatcctcccc agtggtagcc tgcctcagga aatctccatt cccacggtgt gaggtgggca 3886 cagtgggtgt catccccatg cccattttat acctgaggcc aggatgggca agggccagag 3946 tgtcacagct ggcagatgga ctgagcccat cccctgatgc caactgccac tccctctggt 4006 tcctgtgtct ctgccgtccc tctcgtgttc gcctcttcgt cagggcgagg aggcaggcga 4066 gcctgtgtct gcgcggtgtt gggggaac cc tgggtgcctt ggcccagccc tctgccatag 4126 ccagcagcct gcccctgctg cttctgccct acagatgccc tgatgcagaa ggctttcaac 4186 tcctcgtcct tcaactccaa caccttcctc accaggctcc tcgtgcacat gggtctgctc 4246 aagagtgaag acaaggtcaa ggccattgcc aacctgtacg gccccctgat ggcgctgaac 4306 cacatggtgc agcaggacta tttccccaag gcccttgcac ccctgctgct ggcgttcgtg 4366 accaagccca acagcgccct ggaatcctgc tccttcgccc gccacagtct gctgcagacg 4426 ctgtacaagg tctagactca aagcctctcc catcccttgg cctggaccag tgagctgggg 4486 agggactcgg atgaactgag gcgcagccta cgccattgcc ttggacagga ctctggccac 4546 aggcagggcg ggtctgtgtc ccatgtgtcc tgtcagtccc ctgagtatgt gtgtgggtgt 4606 ggcgcatgtg caggtctgtg cctcctgtcg ggatttgggt tttaacgtct tctgctggcc 4666 cagccctgct ctgttgtggg gagttggccc ccaggggaaa gggctgtgag ctgctccgcc 4726 attaaactca cctccacctg agggcgctct gctgatctcc gcctgggccc tgatggccgt 4786 ccccacccac ctgccttccg gcccggctcc ctggcggagc cagaacccag ggagttgccc 4846 gcgtgctgtc cttcccctct gtgttgtgat tgggttgttt cctgccctgc ctggggctgc 4906 ttctcgtcac caagccctgg tcctgcggca gct gtcaccc ctaccatcca taccactgtg 4966 ctgaccgctc agcctgaaga gcagagaatg ccatgggtgg gactgtgggg gtcggatcgt 5026 ggggttgttg gcagagggca accctgggcc ccacaccatg tggacaggca gacactagat 5086 tgtccaggag caggagctgc tgggactgcg ctggccccgg acctagtggg ccttctcctg 5146 gctgctgaga tgtcgtctgt gactggcctg gctggagggg gagtgttgac aacccaaagc 5206 tgttctccag tctggggagg gagaggcagg gtccccaatg tccgagctgc atctggacgc 5266 tgctcttaaa ggacctcctg gggcagggga gcggtagggt ctggactggg cagatgctgt 5326 atgacctccc tgagcacccg tgactgcccc atgctttccc ctttgtgctc tgtgtgtgtc 5386 tgggctgtgc ccgggggctt cacaaataaa gtcgtgtggc agc 5429 <210> 45 <211> 5179 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (36) .. (956) <400> 45 gaggaaagcg cgcgggagag cgagctgcgc tttag ctg ctg cgc cac gcg cgc 53 Leu Leu Arg His Ala Arg 15 5 ctc ggg cct ggg cgc aga gga tcg gcc ggg cgc ggc ggg Aag Gag Gly Gag Aly Gag Gly Gag Gly Gag Agly Arg Gly Gly Lys Glu Ala 10 15 20 gcg ggc agc gag gag cgg ctg gcg ctc gag gcg gcg gac ggc acc atg 149 Ala Gly Ser Glu Glu Arg Leu Ala Leu Glu Ala Ala Asp Gly Thr Met 25 30 35 tcc cgg ggg gtg aag agc gag tac atg aag cgc tac cag gag 197 Ser Pro Gly Ser Gly Val Lys Ser Glu Tyr Met Lys Arg Tyr Gln Glu 40 45 50 ccg cgc tgg gag gag tac ggg ccg tgc tac cgc gag ctg ctg cac tac Trp Glu Glu Tyr Gly Pro Cys Tyr Arg Glu Leu Leu His Tyr 55 60 65 70 cgc cta ggc cgc cgg ctg ctg gag cag gcg cac gcg ccc tgg ctc tgg 293 Arg Leu Gly Arg Arg Leu Leu Glu Gln Ala His Ala Pro Trp Trp 75 80 85 gac gac tgg ggc ccg gcc ggc tcc tcg gag gac tcg gcg tcg tca gag 341 Asp Asp Trp Gly Pro Ala Gly Ser Ser Glu Asp Ser Ala Ser Ser Glu 90 95 100 tcg tcg ggc gcc ggg ggc ccc gcc ccc tgc gcc ccg ccc tcg ccc 389 Ser Ser Gly Ala Gly Gly Pro Ala Pro Arg Cys Ala Pro Pro Ser Pro 105 110 115 ccg ccg ccc gta gag ccg gcg acc cag gag gag gcg gaa cgg cgg gcg 437 Pro Pro Pro Val Glu Pro Ala Thr Gln Glu Glu Ala Glu Arg Arg Ala 120 125 130 cgc ggg gcc ccg gag gag cag gac gcg gag gcc ggg gac gcg gag gcc 485 Arg Gly Ala Pro Glu Glu Gln Asp Ala Glu Ala Gly Asp Ala Glu Ala 135 140 145 150 gag gac gc gag gac gcg gct ctg cca gca ctg cca gtg aaa gat gta 533 Glu Asp Ala Glu Asp Ala Ala Leu Pro Ala Leu Pro Val Lys Asp Val 155 160 165 gaa gat aaa cct gaa caa caa acc aga aca aga gag act gac aaa taca Glu Asp Lys Pro Glu Gln Gln Thr Arg Thr Arg Glu Thr Asp Lys Ser 170 175 180 ccc acc agt act gag cct cga cag caa cca agt gcc tta ttt gct aga 629 Pro Thr Ser Thr Glu Pro Arg Gln Gln Pro Ser Ala Leu Phe Ala Arg 185 190 195 gga aac agg aaa gcg gtc aaa agt ccc caa aga tca tcg agt aaa ata 677 Gly Asn Arg Lys Ala Val Lys Ser Pro Gln Arg Ser Ser Ser Lys Ile 200 205 210 aaa gaa aac aag cat cca ttt gct ctt tat ggc tgg gga gaa aaa cag 725 Lys Glu Asn Lys His Pro Phe Ala Leu Tyr Gly Trp Gly Glu Lys Gln 215 220 225 230 acc gat aca gga agc cag aag act cac aac gtc tgt gcg tcc gct cct 773 Thr Asp Thr Gly Ser Gln Lys Thr His Asn Val Cys Ala Ser Ala Pro 235 240 245 gtg cac gag att cat gaa tca gca tta cga gcc aag aac aga aga cag 821 Val His Glu Ile His Glu Ser Ala Leu Arg Ala Lys Asn Arg Arg Gln 250 255 260 gtg gaa aaa agg aaa ctg gtt gct caa agg cag cga gct cac tct gtg 869 Val Glu Lys Arg Lys Leu Val Ala Gln Arg Gln Arg Ala His Ser Val 265 270 270 275 gat gtg gag aag aac aga aag atg aag gct tcc tcc tcc tcc aac cca 917 Asp Val Glu Lys Asn Arg Lys Met Lys Ala Ser Ser Ser Glu Asn Pro 280 285 290 tgg atg aca gaa tac atg agg tgc tat tcg gca aga gct taaagaaaca 966 Trp Met Thr Glu Tyr Met Arg Cys Tyr Ser Ala Ag 295 300 305 cttgcgtgga cagcctcttt taaaaagtgt aaatgactga aaggaaaaac aaaacaaaaa 1026 ccatcaaaag aaacggacac aggtttaaga aaccaactga ttatgcaagg ttttttttag 1086 ggaatttgta aaagattgtt ttattttgat gaata ttggt cacctacctc ggcagtaggg 1146 cagacagttg aagccataga catttggtta tttatgaaga taattcccta aatctttgat 1206 attcttataa ggtttttgtt ttaaagcatc ttaatctttt aagatactga caccaaatgc 1266 ctttaaatgg caacagatgc ttacagttca gtattctttt cataagctta ggtagagcct 1326 attatcatct tgttctaaat aactttccag attccatagc tataagatca ttccatccta 1386 cagcataaga ctcgttttcc ttatatgccg ttttgtttgt gaaagaatat caagtcaaaa 1446 atgagtgtca gcactactac tgattccatg tataatgaaa gtagaacttt gctagttcct 1506 gaaaattttt aacttatttg tatttcagtt cagcagcatc tttatgtaga ttgtgatatt 1566 taagaattat ctgggctggg cgagggtctc tttttctctt tcagtgatca tctaggcagt 1626 tattatttaa tagtttaata gctcaagtac attccaatag acgaagtgca cacaacacaa 1686 tatgtgtgaa cagtagtagt aaagtttctt ttgagtagtc aaagactcac tttttttatt 1746 gccttttttt ttttttttta aagaatacat actgtggatt cagtcccttg tcacacttga 1806 ccttttggca tacacccact gtggactttt gcctcttctg taatggctgg caatgacatt 1866 tcaaacttac aatctggaat tgcacttggt acattggcat tgcttgttcc actgggatgg 1926 ggaccagtgt gaagatgcct gttagataga ctgcccaccc ctactttctc tttttcttta 1986 tagcacttaa caataacaaa gtcttgatga tgtacagtat tcaaacttta ggttgaaata 2046 cgttactctt tgattcctag ccagtagatc ttatctacac tttaatggga gagaatggtg 2106 gtgtgtgggt aggcacaaat ttatgtaaat agtgctcctt ctctttagta tgtttgcttt 2166 gggggtagaa aaatggtttt aacaaacact ggtttccatc aaatgaatga tgtcttctcc 2226 atcctgtgga gacaagaatc tgctagaagg atatgtgcta agttccttat aagagataat 2286 ggtgctctgc ctatgccagc ttggcacccg aagatgtgtg agtggacgtg aggctgagta 2346 ttaccttagt atttttctct gggtctttgg aaaaccatag tcaattttta gaacatattg 2406 ctttcattcc ccataaactc ttcacacatg ataactgttt aagctttgaa aacacatact 2466 gaagtattgt gagcttaaaa aaacttttta aatatttgca tagttttgag gtgaatttgt 2526 ttccttacag atctctccta atcattgaga tgtatatttc aaaagaggaa attttacatg 2586 ttgtccaaaa cagccttgct agtaactggt gaattttggt attaactatt attaaagtct 2646 ttaaacgaca caggtaccta aagatcacct taatgtggca atttgtgatg gtgtagctag 2706 ctgattgtga aaactgttcc tttaaagtcg cttcttgcat gttcggtgtt agtcatccag 2766 ctcaggcttg tgttgcagct gacaatctag gaaagacggc ctta gagagt ggtgcaggcc 2826 ccacactgac ggactgcctt agaaacccga cttcctctag actttgaacc gccagacttt 2886 tctcttgttt agaaaacaaa cttatattta atgtacttac tacttaaaac tccagacaga 2946 gatataatgt agaaggcaaa tattggccaa ttttttcctc tttttaagtg gaagacaaat 3006 gaacgggatt tttaaagtgc ttttaaagtg catgaatggt taataaatca gtatgaattg 3066 taagccttca tcttacatcc aagtccttag ttggttaggg tttcttttct ttctttttta 3126 aagagtgtca attacctttt gaacctgtga aaatttgata gttgttaaca gtctgatggt 3186 cctaattctt tcttttcatt ctagaaatga atgtggttgt aatcatgttc ctaattcttg 3246 ggacaacctg caagacagtg agacagttta aaaattacct ttcatgttga aaaagtctga 3306 aacagagaac ccaatgatat ttaaaataaa tgctacataa aactcttttt aaaattttga 3366 ttttaactta attaaaacaa tgtcataaat atgctttttg attttgttac tgcttttaat 3426 attaaagtaa tagaatattg aagcaatatt gtctagcact ctgctggaca ttaagtccgc 3486 gggaggagaa gtgaacagga atcgattctt tgtcttttaa ctgcccttag ttaggagatg 3546 ttaaaatact tggcacctct ggttatatgt atgttatgtg tgttctcccc cctaaaattt 3606 ctaagcacat ttattcactt ttaaaatgaa tctttaaaag attatagtta gtagttatag 3666 ttaatatttt atttacttgg aaaaatgtga ataaatggat cttcaaaaga ttcattttaa 3726 aaatgaataa atgtataata ggctataggt gatcttactt gcgtattagg taggaggcac 3786 atatttatac catttcatat gtaatatctt tgtcattgtg tttcatcgaa gatcaattgc 3846 tagcaacttg aagggtattt atacttgggt cacttgaact cagctgacta aattgtaaga 3906 acgagagcaa gcaagatggc tgttattgga agccataact tccagaagat aattctgcac 3966 aattcgtaag ttaaaaaaaa tctgtagggt cttccactat cctttttcag gttgataatg 4026 ctgttctggg cacacacttt gtaaatggaa tgttatggta cagtcgcctc tcagtatcca 4086 tggggcattg gttccaggcc tcccttagga tgccaaactc catggatact caaacccctt 4146 ctataaaatg gtgtagtatt tgcatatatc ctagacacat cctcctgtat gctttaaatc 4206 atctctagat tacttaaaat acctaataca atgtaaatgc tctgtaaata gttgttatac 4266 tatattgttt agggaataat gacaaggaaa aaaaagcctg tacatgttca gcacaagtga 4326 aaccatcctt tttgccccca aatattttca atttgtattt ggttgaatcc atggatgcag 4386 aactcacgga tacagagggc cgactgtact ttctttaaag tgttcaaaag tattactagc 4446 aaagaggagg aggagcaaag catatatcag aagtaaaaca atttttcttg ttga ctgctt 4506 tggtaaaaaa cagtttgatg gatagtttta catttcactg gactagataa aaaatggtgc 4566 taatatttat gtagcttgat gctatagttg ctttggtatc aaacttaata cctaacccat 4626 ataagatcct tattatataa ttttgtgatc agtaaaatga tattttaaag agtgatctta 4686 aaaatatgac ctggtcattg cacaacgttt gcatttgaaa tgaatttttg tactataggg 4746 tggatatgga gttattcagt gcaagtgtgt gcttaatatc aaaccctatg caaggagcta 4806 tgtctagatt tttggtccaa atttgcctcc ttcaagccta ctagtgtgag atggaaaaaa 4866 atcgattgct cttttaatat tatttccatt ttgaaattct cgacacttga atgaaggcag 4926 tagaggcctc tttttggatt tctcttctaa taacaaaact ttatttaggg aaggtttccc 4986 tgtgctatcg taagtttgtt ttgagcactg cattcacttt aaaattctgg aggaacaaag 5046 gctgggcaca taatcag tattgatt cagta tattgag cattacattatt gagcattatatt gagcattatatt gagcattatatt gagcattatattg <210> 46 <211> 5551 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (610) <400> 46 a gct ttt gga agt ttg agt aat tcc agc cca tcc agg tcc atg ctg agc 49 Ala Phe Gly Ser Leu Ser Asn Ser Ser Pro Ser Arg Ser Met Leu Ser 1 5 10 15 tgt ttc cga gga ggg cgt gcc cgc cag aag cgg gct ttg tct gtc cac 97 Cys Phe Arg Gly Gly Arg Ala Arg Gln Lys Arg Ala Leu Ser Val His 20 25 30 ctg cac agt gac ctg cag ggc ctg gtg cag ggc tct gac agt gaa gcc 145 Leu His Ser Asp Gln Gly Leu Val Gln Gly Ser Asp Ser Glu Ala 35 40 45 atg atg aac aac ccc ggg tat gag agc agt ccc cgg gag agg agt gcg 193 Met Met Met Asn Asn Pro Gly Tyr Glu Ser Ser Pro Arg Glu Arg Ser Ala 50 55 60 aga ggg cat tgg tac ccg tac aat gag agg ttg atc tgt att tac tgt 241 Arg Gly His Trp Tyr Pro Tyr Asn Glu Arg Leu Ile Cys Ile Tyr Cys 65 70 75 80 gga aag tcc ttc aac cag aaa gga agc ctt gat agg cac atg cga ctc 289 Gly Lys Ser Phe Asn Gln Lys Gly Ser Leu Asp Arg His Met Arg Leu 85 90 95 cat atg gga atc acc ccc ttt gtg tgc aag ttc tgt ggg aag aag tac 337 His Met Gly Ile Thr Pro Phe Val Cys Lys Phe Cys Gly Lys Lys Tyr 100 105 1 10 aca cgg aag gac caa ctg gag tac cac atc cgg ggc cat aca gat gat 385 Thr Arg Lys Asp Gln Leu Glu Tyr His Ile Arg Gly His Thr Asp Asp 115 120 125 aaa cca ttc cgc tgt gag atc tgc ggg aag tgc tttca ttc caa ggt 433 Lys Pro Phe Arg Cys Glu Ile Cys Gly Lys Cys Phe Pro Phe Gln Gly 130 135 140 acc ctc aac cag cac ttg cgg aaa aac cac cca ggc gtt gct gaa gtc 481 Thr Leu Asn Gln His Leu Arg Lys Asn His Pro Gly Val Ala Glu Val 145 150 155 160 agg agt cgc att gag tcc ccc gag aga aca gat gtg tac gtg gaa cag 529 Arg Ser Arg Ile Glu Ser Pro Glu Arg Thr Asp Val Tyr Val Glu Gln 165 170 170 175 aaa cta gaa aat gac gca tcg gcc tca gag atg ggc cta gat tcc cgg 577 Lys Leu Glu Asn Asp Ala Ser Ala Ser Glu Met Gly Leu Asp Ser Arg 180 185 190 atg gaa att cac aca gtg tct gat gct ccc gat taagatggta aagaagtluca 630 Thr Val Ser Asp Ala Pro Asp 195 200 cccaaacaaa gcacattaat caatgcatat ttgtgatttg ctttgttgta atctttggtt 690 ttcccaacca tctggaaatc tcttggtctc ttggcagttt ttctaaagtt tctggatgga 750 acacttcgtt gtgtttatcc tttcccctgc cctccctccc cgaaggagct caaagcatga 810 agggcaacgc atccagggaa aacacaggct gacagtattc ctctttggct gaactcttaa 870 tccaaaatct gccagtgatt tagctatgcc aactggttga ccctccattc tctgccaaga 930 ggcatactct ttctcattgt gtgcgctggc agcagtgcac ttccacggag ggagattagg 990 atgccgtcag ctgatacaaa tgggtaacct tttctaattt aaaattcctt ttagggggta 1050 gttagacaat ttatatatat atataataaa actattatta tatatatagt atatatacat 1110 tttcaaattt gattttattc tggttgaggt gaatgtaaga ggaatatata atttaataca 1170 atgtgaacag ggcttctgag tctatctcat ccctacctaa tatgttaggg ttttgcccct 1230 tcatttccct tacaaaagaa tgttagtagg tttatattaa tcattgtgtc caaaagcaag 1290 caaagcaaat cacagtgttc acagctctgc ttcataacaa atacataaac caaatgccat 1350 aaaatttctt caactctagt tggaaaccgt ttggaatttt tgttagttgt ccagcaggta 1410 agctggatga cctgtggtgc tgaccttttt acatagtgta gtgttatatt agcccccaaa 1470 ggagcagtgg ttttcaaggt ttttactggc ctacaaatct accttcattc cgtactgtag 1530 aaacatacat accaggtaac taaatcgaat cactctctat catgagttag tactcactcg 1590 cacttaagga aagggattt g tagttctgtc tacaaaattc tccaagcagt gttgtggttt 1650 tttttgtttt tgtttttttt ctttctcttt tcaaacagcc agttcaggtg cacagcaact 1710 ttttctacat gcagttccca gggaaactgc agaacttaga atttgtactt tttgtaaagc 1770 tatactctat gggaattgca agcaatatat ctatcttagt attgtgtgtg ctaatgagag 1830 cctcagtggc tcccccactc tctcagtgtt tcctgcttaa agaaccaaca gtttaaaagc 1890 cctctaagat actctgtgtg tcaccaaatc tgtgtgtcac cattttttgg tcatgtggtg 1950 ctatttttgt taagtgtctt tttaggtcag tatagttgta gaaaatgtga aatctgatgg 2010 taataatgaa ttataattgt tttcctctct tgagttcata gcttgaaaag agacctcaaa 2070 agcatgtgct ggcaaacacg ttactgtatg aaaacatacc tgagtccatt tgaataatgt 2130 tttattagta ctttcggaaa tgtcttcagt tctgtattgt gttcacatac acaaacaggc 2190 tttacaagat tgcttcggta ctgtaaactc tggcagagag taattttgta ggcagtttgg 2250 tggtgagttt gtgctgcagg ctgcctgtgg gatgtcagcg ttctggtatc tgcctgagaa 2310 cctgggctct gagacgcaca accagtgcac ctccatagga gaacagtgca gccacctaaa 2370 agaaaaacga acgaaggacc agcctcagag gctagaagtt aaaggaatac agaattagat 2430 gtttgctggt tttctgtgct ttt ttggctc ctaaaatacc aatggtggat ttgtttttgt 2490 ttttgttttt tgttttgaga aataaaaagt cattcaagcc ctttgtgtgt aatagccccc 2550 aggggtggca gctgtgcagt cgcatctctt tggcacacag gatctgttca cgtgtgaact 2610 gctgcgctac acatcagtgt taactcccta cagattacac tctaatcccg ctgctcccga 2670 ggagcggctt tgctaaatcg ggtatatagt atatgccttt ttcctcgtca aactgcctaa 2730 gtaggggttc gttctctccc tgaagcactt gttcaactcc tgttaaagcc gcgtgcctca 2790 aggggaggct ggaccccaag tgtttaccca cttaaatatg ttctggggtt tcaggtaaat 2850 gtttgtgggt tttttttttc cttacatgaa taagtttggt tttgattttt ttttaattga 2910 atgcaaaaaa tttgtgttgt gatacaaatt aagtttgtga caagaaatgc ccaaatccaa 2970 ggacataaga ggtcaagctc agggaaggaa cctccttttc actcaggctt ggggcctcca 3030 gcgaggtttc cagagcattc catggtatga gagacagtga ggagggaggg cacctggcgc 3090 gggcacttcc agcgtcctgg ctcttggcat tgtccgtctt aaccttattt acatggagtt 3150 ctttgtattt gtgaatctgt ttaactggtt tgagtttacc aaagagtgac ttatccaaaa 3210 ttgtctttga caaaaatatc cattgctttg attgtacagt tcaggttcaa acattgtaat 3270 gggactgtta aggggcagaa aattgattg a gtttctctct aagaatcatg attccacatt 3330 ttgcaagttc cacttgctcc cattcgtgtt gctaacactt taccctttcc actgctcgca 3390 gtgttaagaa tgaattctca agccataaca cagtactgta aagttccgca gggcttcgag 3450 ggaggcagcg cctaggccag cacggagctg tgtagcctct ctgagcgttc gcactgtcat 3510 gcttcccagg ggtgtgactg gtgagagatt aactccattc agatcgggca gcagcaatta 3570 attgtgcctt gccgcatgag gatgtgtcag gaggattaac atgaccacag aaccgaaaca 3630 ttctctccct gaagttcact tcacgtctcc gcagacgaag tacgctgtgt aactccttag 3690 agcaactctt tttggaaagc aaagtcccta tttctgtaca gttttaggtt aggtgtttca 3750 tttataacag atgcagaaat caattaagat aaagtgatat gtgaagaaat cttttacagt 3810 aaaatatatc ctgaattcat ataggcttgt tcataattga gtctcttctt gagctacctt 3870 ttcaatatta gacaatgtga agacagtgac agcgtccttt tctagagata tttagcctgt 3930 tattacaaac tgtgaagaca aagaatttta tacttttact aatgtttgtg gttttaaaca 3990 gttattttca ttctaatcag ttctctaccc tctaatttct actaaagctg taaatacatt 4050 tagaaattat atttgtaaat acagtatatg gagacaagtt aattttttgg tcagtggaaa 4110 aagcctccca accaattggc cctgccttgg cag ttgtgtt ttttgttgtt gttgttgttg 4170 ttttagttta gttttttttt ttaaacagca gaaaggatac tgtcggttca ctgttgagca 4230 gaatatactg tagaacgaaa atgataattt ttaaatcttc cagagcatga gtaaatgtct 4290 tttctaatga tagcaaatat aaccaactct ttgtttttcc cttagcccag accatataga 4350 cctgcgtatt ttgtgtgtgg ttttgttttt atttttgttc ttacagccta gaccctagga 4410 aaaatttgca ggaacacgaa acaagggctg gggggaaaat catctatgtg aatgagcttt 4470 actttaaaga gatcaatgta ttttatttta tcaacttttt ctcttagtta ctgtgatttt 4530 tgttgttgtt gtcctcgtta ttgttaaatt ctgtaatggt ttcctgtgaa gcctccactg 4590 aaagggactc aaatatgcaa cacctaaact attttccaag ggcacatgcc ccttgaatgg 4650 tgcttctaga ctggtcaggg ttatttatta aattttatat atgaaagtat tggggaatta 4710 tgtaaattct ttatatgaaa ctatctagtt cataaatcat agatttcata ttactcagtg 4770 caactgaact aaaagttcag aaaagtcatt cacattgttc caaatttgta atggttgtca 4830 catgtcacat gcgtcttttt cagtaagtgc cagagtgttc ccactgtttc tgcccagtgc 4890 ttgacttctc ggcccggaag agaacctgct ttctctggtt tccttcctga gtctggcaca 4950 gacggggcta ttgtagttct tgatcaagtc ctggagtca g ccttgcctgg ctctccttgt 5010 agcagattca gtccacagac ctcttgctgc ccctcagtga caagtatgct gtgaattcaa 5070 cctttggact tgctgcccaa gcctttggtt gctgccctga ctattgtaag aggtaaactt 5130 acctggtttg tttgagaatg accattttcc taatgtgaaa accatctctc tcaccacttt 5190 tattagtagg gctaacattt ttttccgtta taaatggttg agcaatttga atgacttaac 5250 acagtgtcat tatcttgcaa tataaactgg taacctcaca actccacact tcatcaccat 5310 atgaagtaaa tgaagctagc taagcggatg ctgtatcaac tagtaacttg ccattaagga 5370 ttattttata gcatgaattt aagactattt attcaaatga tattttactc ttgtattcac 5430 tttgttttag atttgtgaca tgaatatttc agtgctgctt aattttgttc tgaattcttg 5490 tttcttgctt gtaaatggct tttttatggt ataaataaag tcaatggaca ttgctgtttg 5550 t 5551 <210> 47 <211> 5403 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (88) .. (1173) <400> 47 ggacccgaaa cggggaagtt gtcttgtttg gagaggttag tagagcagcg cgcgcgtcac 60 cagagtcgtt tctcttcgga gtcttag gtg atc gag ggt gtg ccc agg ggg cgg 114 Val Ile Glu Gly Val Pro Arg Gc cct gc cct gc cct gc cct gc cct gc cct cg cct gc cct gc cct cg cct cg ccc 162 Thr Cys Leu Arg Leu Pro Phe Pro Pro Asn Phe Gln Thr Cys His Pro 10 15 20 25 ggc gcc gac ggc cct gtg cag ggg aag cag atg gag ttc aag ctg gag 210 Gly Ala Asp Gly Pro Val Gln Gly Lys Gln Met Glu Phe Lys Leu Glu 30 35 40 gct cat cgc atc gtc agc atc tct ctg ggc aag atc tac aac tcg cgg 258 Ala His Arg Ile Val Ser Ile Ser Leu Gly Lys Ile Tyr Asn Ser Arg 45 50 55 gtc cag cgc ggc ggc atg aag ctg cat aag aac ctc ctg gtc tcg ctg 306 Val Gln Arg Gly Gly Ile Lys Leu His Lys Asn Leu Leu Val Ser Leu 60 65 70 gtg ctg cgc agc gcc cgc caa gtc tac ctg agc gac ccg tgc ccc Ser Ala Arg Gln Val Tyr Leu Ser Asp Pro Cys Pro Gly 75 80 85 ctc tac ctg gcc ggt ccc gct ggg acc ccg gcg ccg cca ccg cag cag 402 Leu Tyr Leu Ala Gly Pro Ala Gly Thr Pro Ala Pro Pro Pro Gln Gln 90 95 100 105 cag ccc ggg gag ccg gcg gcc ggg cca ccc gcc ggc tgg gga gag ccg 450 Gln Pro Gly Glu Pro Ala Ala Gla Pro Pro Ala Gly Trp Gly Glu Pro 110 115 120 ccc ccg ccc gcc gct cgt gcc tct tgg ccg gag acc gag ccg cag ccg 498 Pro Pro Pro Ala Ala Arg Ala Ser Trp Pro Glu Thr Glu Pro Gln Pro 125 130 135 gag cgc tcc tcc gtc tca gac gcg ccg cgg gta ggg gac gag gtg ccg 546 Glu Arg Ser Ser Val Ser Asp Ala Pro Arg Val Gly Asp Glu Val Pro 140 145 150 gtg gcc acg gtg act gga gtc ggg gac gtt ttt cag ggc gga gag gcg 594 Val Ala Thr Val Thr Gly Val Gly Asp Val Phe Gln Gly Gly Glu Ala 155 160 165 gac gcg acg gaa gct gcc tgg agc cgc gtg gag ggg ccg cgc cag gcg 642 Asp Ala Thr Glu Ala Ala Trp Ser Arg Val Glu Gly Pro Arg Gln Ala 170 175 180 185 gcg gcc aga gag acc g gcc gga ggc tgg ggc gtc ttc ccc 690 Ala Ala Arg Glu Ala Glu Gly Thr Ala Gly Gly Trp Gly Val Phe Pro 190 195 200 gag gta tct cgt gcc gcg cgc cgc ccc tgc ggc tgc ccc cta ggc Ggg Aggla Al a Arg Arg Pro Cys Gly Cys Pro Leu Gly Gly 205 210 215 gag gac ccg ccg ggt aca ccg gcc gcg acc ccc cgc gct gcc tgc tgc 786 Glu Asp Pro Pro Gly Thr Pro Ala Ala Thr Pro Arg Ala Ala Cys Cys 220 225 230 tgc gcg ccg cga cca gcg gag gac gag ccc ccc gcg ccg ccc gcg gtg 834 Cys Ala Pro Arg Pro Ala Glu Asp Glu Pro Pro Ala Pro Pro Ala Val 235 240 245 tgc ccc agg aag cgc tgc gcg gcgg ggg gg gcg ggc 882 Cys Pro Arg Lys Arg Cys Ala Ala Gly Val Gly Gly Gly Pro Ala Gly 250 255 260 265 tgc ccg gcg ccc ggc tcg acc ccg ctc aag aag ccc cgc cgg aac tta 930 Cys Pro Ala Pro Gly Ser Thr Pro Leu Lys Lys Pro Arg Arg Asn Leu 270 275 280 gag cag ccg ccg agt gga gga gag gac gac gac gcg gag gag atg gag 978 Glu Gln Pro Pro Ser Gly Gly Glu Asp Asp Asp Ala Glu Glu Met Glu 285 290 290 295 acc ggg aac gtg aac ctc atc agc atc ttc ggt tcc agt ttc tcg 1026 Thr Gly Asn Val Ala Asn Leu Ile Ser Ile Phe Gly Ser Ser Phe Ser 300 305 310 gga ctc cta cgg aaa agc ccc ggg ggc ggc aga gag gaa gag gag gga 1074 Leu Arg Lys Ser Pro Gly Gly Gly Arg Glu Glu Glu Glu Gly 315 320 325 gag gag agc ggt ccg gaa gcc gcc gag ccc ggg cag atc tgc tgc gat 1122 Glu Glu Ser Gly Pro Glu Ala Ala Glu Pro Gly Gln Ile Cys Cy 330 335 340 345 aag ccg gtg ctg aga gac atg aac ccc tgg agc aca gcc atc gtg gcc 1170 Lys Pro Val Leu Arg Asp Met Asn Pro Trp Ser Thr Ala Ile Val Ala 350 355 360 ttc tgagcccttg gcccc gcgcgggcgcggcgcggcggcggggcgg ccggctgcga ggacgcccag agaccgcggg cgctgagcgc 1283 gttgggcaga ctggttgcct ctgggcatcg caaactgccc ccgggcgcat ctggcttatc 1343 tggagacctg ggagcttgag gctcattgga agaggacgat cgttaacttt tgtgtttgtg 1403 tatgtctgtg tatgtaagtt tgtcttgtgg cattaagact attttgctct tctggaatgc 1463 accactcctt ccccagggtt taagagattg ggggcagaca gggactttcc tctgccggct 1523 gcgtggagaa ggaagcggct aaaaggtttg ggccggggag ttccccattc gttctccggg 1583 gagggaggga ctttacacct acccctcacc ggaaagctag acccgcttca gggccaggag 1643 tggcgtttcc gcacaggatt tcctaagacg agagggattt agccaagagc acagacttgg 1703 a ttccttctg tccctcccca cctttctctc ccaatgaaga aacgtttata tcctgtgatt 1763 actctaggaa aggggcgtat taacggtcct ttgcttcccc gcaggggaga aaaagcttga 1823 cgaacttcac agaagagttc aagcttggaa ataatggagt ttatagagaa aagatatatt 1883 tttaaaagct ctaggtcaga agtactacac agtgctttta aaaagtgttt aatgagagtt 1943 tacagacaga agcccgaagt ggaaagacct tatggttttg tagatatggt gactccagtc 2003 tttgttgtat aaaggttggg ggagctgata aggtttttgt acagtatttt ctccttcgtt 2063 gtattgattt ttgtataaaa atgtaacttc tacgtgtcta acacgtatta aatattttga 2123 agcaacgtaa ctgcctgctt gtctgtaata acctgcctgg gttgggaggg aagtgggagg 2183 agggaaacca gggcctgagc tagaaaattg aaggtgtggt tcttagtatc agtcattcgc 2243 agactgagga cattgtttac tgactccact aagtatcaag agagacagaa gcccgaagtg 2303 gaaagacctt atggttttgt agatatggtg actccagtct ttgttgtata aaggttgggg 2363 gagctgataa ggtttttgta cagtattttc tccttcgttg tattgatttt tgtataaaaa 2423 tgtaacttct acgtgtctaa cacgtattaa atattttgaa gcaacgtaac tgcctgcttg 2483 tctgtaataa cctgcctggg ttgggaggga agtgggagga gggaaaccag ggcctgagct 2543 agaaaa ttga aggtgtggtt cttagtatca gtcattcgca gactgaggac attgtttact 2603 gactccacta agtatcaaga gagacacgtt taatttttcc tcctagatca gaggactgct 2663 attagatact aatatcggcg acctgtcagg ttctagaaac ctgccactac aactgccttt 2723 tctaaggtca gtttagacca atttgtcacc caatatgtgg gtgtctaata ctaagtaatt 2783 taaccaactt ttgaagcccc gcttatccac aaaaatgttt ttcagcaaaa ctttgtttcc 2843 tgttaagcta ttaatacggg tcatctttta gctttgtaat tgaaaaaaaa aaagtttaga 2903 tagtagttta ccttaaaagc ccattcgaac tgacatagga agatgaaaga gactgacttg 2963 tccaaattgt caggtccacc tctgcatcac agtggatgtc aggatgtaaa ttttcagttt 3023 ttctcttaca tctagaaagt aaatatattg ctgagaggga aattgtttgc atcaaaccag 3083 ataaggaagg agggctaggc aaatttagtt ctcatttagc aaaacttcct gatttgtttt 3143 gttacttaaa tggtgacatc agtgtttggt catggtagac acttaggtga tgatagccaa 3203 aacatccatc gattttacta aaatcactgc cattaagaga gttttttgtc tcttcatgtt 3263 caatgtttga aaggtattca gtaatctatt tcagaagcaa atcaattagg gaatggtgtt 3323 tattaaaata cggtacagtt gccaggactt taaaagatgg tactggtttc taacaactta 3383 cgagtatata g ggtatttaa aagatgggag agattgaaga aagacaaagg tttaaaggtc 3443 atagccttcg agcataagag gcatatgaat ggtgtcttgg ccttaactcc caattatacg 3503 aacttctgtt ttagctgaat aggccagtgc ctcgtgcctt gatatttcgg caaatctatt 3563 agtggttcct taagcatagg gaactttgta ctttatgctc tgtcgccata ataatgtatt 3623 tatagaatta aacattctca aattagggtc ttgttaaact gactttttct ttcagaaagt 3683 agctacttaa attctgttac agctacaaaa gatccatcaa gtgctgactg cttaaactga 3743 agaaggtgtc cagggcctta attctgcaaa catttcctgt tgttagaaag tatgatgctt 3803 gaacagcgat ctcagtgtat tttatgtttt aaagggggta acgtttggtg tgtttaagag 3863 agctgatgtg ttttggatga gactaaagtt gatccttggt tttacattaa gatgaacctg 3923 ggtccatgtg tctgcttaaa gaatgtaaat tggcatactt gataggagga taaagctttg 3983 taggaattag aaaagatcat tctctttttt gttgcagaag cagtatagta tagtagttag 4043 agcatgggcc ctggagccag gctgcttggt gtcttccttt atttatttat ttatttaatt 4103 ataaaaagta aatataaagt gagctatgtt gaccaggttc gtcttgaact cctggcctca 4163 agcaatcctc ctgcctcagc ctcccaaagt gctgggatta caggcatgag ccaccacaac 4223 ctggcctgct tgggtt tttc tatcttggct ctgccaccta gctgtgggtc cttggacaag 4283 ttacttcatc tctctgtgcc tcaggttttt caaatgtaaa attgggataa ttggatctgt 4343 ctcatagggt tgtgaaaatt aatgagttaa tgctcttaga agagtacctc atatgtaata 4403 agcacacaac tgttaattat tgttaatgta gaagttaatt ctgtgtataa atcagataca 4463 ctgtggtcaa agatttgtgt gtatttgtaa gaaaagagga gaatggagaa tctattttta 4523 agtggtccta tgtgtgaatg ctgggttctt ttattcctct ttttctctgg acacttggca 4583 gtcaggaagc tttgttctac caacatagtt ttgttgctgt gaatgtctca caccaaccgg 4643 atgatttttc caattgtatc aaacaactct attttcaggg aggagtaagc tgaagtgaaa 4703 acaggcaagg agcaaagttc ttgttgacat acaaatgctt tctgtggatg agtaaagaaa 4763 aaagtagccc ataaagttat ttttgcttga attattgcgc atggaatgtt taaaacatgc 4823 ttattgatag gttctggaca agagccttcc caatgccaac ctagggctat cacacaacca 4883 aatcagatgc agtgtgacta gaaacgatgc catggtttta gtacctaacc acttcttcac 4943 cactctggga gggacctagt ctcttgatca aattaacctt agctctgggg tgtaaaaaaa 5003 ccttctgact gctgcgtaaa agccagatgt ttaaagtgct ttccaacaag tactccaaga 5063 agatcacatt aatagggatt a caggcgtga gccactgccc ccggcctagt atgtacttct 5123 caaccatgtt gttttaaccc tgtcttccct tttagaaacc atcatttgtt cttggcgatg 5183 ggaactaatg atggaaagcc tgaattgctc ctccaaggtg actgggtttt ctttatggca 5243 ccaaataacc tttccattcc ttctactcat cactgattgg atttgggagt gtgaagtgag 5303 aggaaatggg tcatttgaca actttggtgg aaagcttctc agaataaaga tgtcagaaat 5363 attgggaatg aaattaataa ttataaaact gttccatctt 5403 <210> 48 <211> 5689 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (716) <400> 48 gg ccg gcg tcg gct gtt gtg cgc gcc cag ggg tcc cgc ggg ttt tcg 47 Pro Ala Ser Ala Val Val Arg Ala Gln Gly Ser Arg Gly Phe Ser 1 5 10 15 ggc gca ggg tgg cgc ccg cgg cag gcg gg gcc atg aac ttc tcc gag 95 Gly Ala Gly Trp Arg Pro Arg Gln Ala Ala Ala Met Asn Phe Ser Glu 20 25 30 gta ttc aag ctc tcc agc tta ctc tgc aag ttc tcc ccg gac ggc aag 143 Val Phe Lys Leu Ser Leu Cys Lys Phe Ser Pro Asp Gly Lys 35 40 45 tac ctg gct tcc tgt gtc cag tac cgg tta gtg gtc cgg gat gtg aac 191 Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val Val Arg Asp Val Asn 50 55 60 acc ctt cag atc ctt cag ctg tac acg tgc cta gac cag atc cag cac 239 Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu Asp Gln Ile Gln His 65 70 75 atc gag tgg tcg gca gac tcg ctc ttc atc ctg tgac gcc atg 287 Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu Cys Ala Met Tyr Lys 80 85 90 95 cga ggg ctg gtg cag gtc tgg tct tta gag cag ccc gaa tgg cac tgc 335 Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln Pro Glu Trp His Cys 100 105 110 aaa ata gac gag ggc tca gcc ggg ctg gtg gcc tcg tgc tgg agc ccg 383 Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala Ser Cys Trp Ser Pro 115 120 125 gac ggg cgc cac att ctc aac acc acg gaa ttc cat ct acc 431 Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe His Leu Arg Ile Thr 130 135 140 gtc tgg tcc ttg tgc aca aaa tcc gtg tct tac atc aaa tac ccg aaa 479 Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr Ile Lys Tyr Pro Lys 145 150 155 gct tgt ctg cag gga atc acc ttc acc agg gac ggc cgc tac atg gcg 527 Ala Cys Leu Gln Gly Ile Thr Phe Thr Arg Asp Gly Arg Tyr Met Ala 160 165 170 175 175 ctg gca gacac cg tgc aaa gat tac gtg agc atc ttc gtc tgc 575 Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val Ser Ile Phe Val Cys 180 185 190 agt gat tgg cag ctc ctg cgg gta agg cgt ccc cca gac tgg Asat aaa 623 Gln Leu Leu Arg Val Arg Arg Pro Pro Asp Trp Asn Lys 195 200 205 gtt gtc ctg ctg act gtg gag gga tcg agt gaa gta gat cct tcc aga 671 Val Val Leu Leu Thr Val Glu Gly Ser Ser Glu Val Asp Pro Ser Arg 210 215 220 ttc cag ggg atc ttt ggt agg ata tgg agc aag gtg atg ttg tat 716 Phe Gln Gly Ile Phe Gly Arg Ile Trp Ser Lys Val Met Leu Tyr 225 230 235 taacaaagcat caggtgccag tggaggtgcagtggg gcgaatgag cgg tggaggtgcagtg ggg cccttttcct tgtcctgtgt gatggtgttt gcgcatgtgt gtgccacgtc gggagttggg 896 gggacgtgga agttcacctt gactgagggc ctgcattagg cagggcgctc tgccaggtgc 956 ccaggcacag agggcactgc ccccacagca gacatatgaa cacgattcca gcacaatcca 1016 tcattaaggt agagcaacct ctggaatgct gtcagagtgc agaacccggg atccaggcag 1076 tgctctggaa gggacttgtc tgagctgggt ctaaaggagt gagcctggcc aggcaaggaa 1136 aggtgagggg gagagtgtgc acatgagtgc aggtgcgggg agaccaagcc accttcgggg 1196 gctggccagg caaggaaagg tgagggggag agtgtgcaca cgagtgcagg cgcggggaga 1256 ccaagccgcc ctcgggggct ggccaggcaa ggaaaggtga gggggagagt gtgcacacga 1316 gtgcaggcgc ggggagacca agccgccctt gggggctggc caggcactga cgctggcacc 1376 tgtggcggtg cagccccagc agcagcatgagcatgatgaggattgagcgatcgagcatgagcgagcagcatcgagcgagcat gatt ttgtcaattt ctatataagg aaattaagtg cgttaagaac atcagtcata 1496 aatgcaatta tttatttacg aaaatatttt ccaaatttaa tgtttccccc ccttcctttg 1556 gaagcatttt gatacggaca cccaggatct cacagggatt gagtgggccc caaacggctg 1616 tgtgctggca gtgtgggaca cctgcttgga ggtatgaaga tgaccaggtg acatgtttgc 1676 tttcgagagc ttttcccgga atttcatgct ttctgaatgc tgcaatatag tttgctttat 1736 cttatttcag ataacaagtt gagctttgtt ttaaaagaca gggtcttgct ctgtcaccca 1796 ggctggagtg cagtggtgtg atcacggccc actgcagcct cgacctcctg gactcaagtg 1856 atcctcctac ctcagcctcc caagtagctg ggaccacaag catgcaccac cacgcccggc 1916 taatttttgt attctttgta gagatggggt ttcaccgtgt tgcccagact gctcttgaac 1976 ttctgtgttc aagtgatctg ccagcttcgg cctcccaaag tgctgggatt acaggcgtga 2036 gccacagtgc ccggccgagt tgaactttta tcagcgagcc attaggttga cctcccaatt 2096 tccccttttt cctcatgctc tcactgcctc tccgtgacta tctcagtact agctggcagt 2156 tccagctttt ccacggccac gcggacagtc ctgccagctt tgtgctatct gcaccaatgt 2216 cactctgcag cacccgcgtc tgtggtgtgt tcctggcgac gggggtgtat tcattattaa 2276 ctgaaatgtc t catctgcag tacaagattc tgctgtactc attggatggc cggttgttgt 2336 ccacgtacag cgcttacgag tggtccctgg gcatcaagtc tgtggcctgg agccccagca 2396 gtcagttcct ggcagttggg agctatgatg gaaaggtggg aaccagtgca gggcactcag 2456 gaagtccgac cgcccagcgg gccgggccct gcctcacctg tgcatggttt ccttcctcag 2516 gtgcgcatcc ttaatcacgt gacttggaaa atgatcacgg agtttgggca tcctgcagcc 2576 attaatgatc ccaagatagt aagtctggaa cacgtgtttc tgcctgagca ggctgttggg 2636 gagggcggtg ggaaactgct ccttcacttt gctttcttga ttgtggttta ttatttaacc 2696 gggcacttcc atcaccgtaa acttgctact gtgacatttc acgcgtctgg ccctgccctg 2756 gcctttgttc ttcctcctcc acgctgccca aagggtctga agtgggcctt gccctggcct 2816 gtcctctgcc gctgccaccc cagtccagtt ttctcctttg tggtctgtct ggatgcagat 2876 ccctgtgctg tacagagtgg ccagggtctc ctgcccccaa acactgggca tctgctgtcg 2936 tgccaggcac tgtgctctgg gccgcagcca gagaagaaga gacagacccc tgcacttgca 2996 gagtgcggct ggagagacag ggaaggggct ggagagctgg gtgtctccac ggggtggcag 3056 ggagtggcca ccagcgaggg atcgcaggca cagatgctgc accagtgatc agggactcgg 3116 ggagggagcg ttccag gcca agggaacagg aaatgcaaag gccccgagga gtgggccacg 3176 catccatgtg tgcagcgggc actgcgctgg gagccagaga caaatgctgc cctcctggtg 3236 ttgacctgta accgacagag ctgagtgaaa ggcggcttgg attcgatgaa gaggccagtg 3296 agtggctggg gctgcgcatg ccagatcagc cactgccggg gatgcatcct ggaggggtgt 3356 ttaagtgaag accaggagga ggagctgcgc ggtgtctggg cagaaagggt gtttcaggca 3416 gaggggcctc ctgacgtggc cagtggcttg tgtggctgga ggccagggtg tctggacagg 3476 tgagcccgag cagggctggc cacacaggtc ctgaaggttt gcctgtgatt cctgcattct 3536 ccaaatccct tcgccacaca gcagcagagc atgctttaaa ggcatgaacc aggccaggtg 3596 actcccttac ctggggctct tcaggggcgt aggggctgcc cgccttccac tgagcctggg 3656 ccgctgtcct ttgcttgcca ggctctcggg cacagatgcc cccacctcgg gtctgtgtct 3716 gctgctcccg gggcctctgc tgtgttggtg caagtgttct ctgtatcctc ttatcacgga 3776 gggaaggctg agcccactcc cttgctggat gatggtggct gcagtggtct cccgtctgta 3836 atcacagggc acacatttgc tgcctgtgtc tcaaagggtg ggctcctcag caggacacga 3896 gagagggtgg ctgggtgatc tcagctctcg ggactgcggg gttcgtgctt ccgtctctcc 3956 cggtggcagc aggaccagct g tcatggcag gcacacctgt tgaccatgcg ctgtcatggg 4016 catttgccac gtccatcctt ggcttccggg tccctgtcct gagccgggcg tggccacctt 4076 gtgtctttca ggtggtgtat aaggaggccg agaagagccc acagctggga ctgggctgcc 4136 tctccttccc gccgccccgg gccggggccg gccctctccc gagctcagag agtaaatgta 4196 agtagcacat gtgatgtcat ttgttttcct ttcttaatgc aagattcctc gttgtccaga 4256 taaacttcgg atgttcctta tgtttaaaaa aaaaaacttt ttttcccttc catgcttcca 4316 gccagtgtgc ccctcagcct gttggctgga ggttgactag ggtctgaatt gcgcagtggg 4376 ccgtgaaggt gcggcttctg ttactgaata tgagccctgg agacccggat ctgacagcgg 4436 gagctccgag gggatgtttt tccggagctc cgagaatgat gtttttcaaa gaaacacttt 4496 tccgtgggtg gcgctcagag tgggtctgga acccggcggt gctcccgagc gctgtctccg 4556 gcttgaggcc cggttctgat gcagcctctt gactctgggc atttcctatg tgtctgtttc 4616 ctcatcgctg aaatgggcat agtaaaagca cccatcccac aggggcatga gggcatctga 4676 aggttgcagg tagaggaagc ggtgccccaa gtgccgacgg gcccaccccg gggctcggtg 4736 tgtgctcagg atgggggtca ggacaggtgc agcctggcac acaggaggcg ctccccagga 4796 gcccaggggc gtccttgttc cacagc ccct gcttctgctg tgatgatggt tcttccacag 4856 ccggaaagtc taagggtact gacgctgagg tggaagggat tgtgaactca gatgctggta 4916 gtcgacagaa aagtgctgag gagttggagc tgctgagatt gcagctagga cctgtccatg 4976 tccctctcca gtcagcccct ggcacgtggg gtccaccccc cacctagtcg ggcctggcag 5036 gtgatggtgc cactctcatc cggggcactt gcgggcaggc ccctcgctgc ggctgccagg 5096 ctttgcttag ctcttcctgc ccttgggccg cactttcctc ccctttgaac agaggagctg 5156 ggttcgcgat gcccgatgca ggcacagcag cctctcagcc gcgtgcgtac ttcccgaaag 5216 ggtgacaatg gcgtgttctt cctgttggtg ttctagatga gatcgcctct gtcccagtct 5276 ccttacagac actgaaacct gttaccgaca gagcaaaccc gaaaatcggc ataggaatgc 5336 tggcatttag tcctgacagc tacttcctgg cgacaaggaa cggtcagttg tgctgacgca 5396 ggtgctgtct caccctttac tgtgtcctgt ggccccaggt gtagaagcga ctggaaaaga 5456 aaatgaagtt gggggtttcc gacacgtcac ctcctttcac gtttctgcag tagccgaggt 5516 gctcacagaa gctccttgga ggcgctgggc ctttgtcctg cagcagccgc aggtccgcgc 5576 atgagtcagg aggcctccac cctgctcact tgctccactc tgctgagtag aaagcagggc 5636 tgggcacact gcagcccgcc ttttgttaag g gtttctcca tttgtaaagg gct 5689 <210> 49 <211> 5147 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2074) .. (2346) <400> 49 gttttctaaa atgagagccg tcagaggcag ttgaaccaga gcgactccat cttgattagg 60 ggctgggtaa caaaaggctg agacctactg ggttgcattc ccaggaggct aggaattcta 120 agtcacagga tgagatagga catcagcata agatacaggt tacaaagacc ctgctgataa 180 aacaggattc ggcaaagacg ccagccaaag cccaccaaag ccaagatggg cacaaaagtg 240 acctccagtc atcctcacta ttcattgtgc accaactata ttagcatgtt ggagtcactc 300 accagtgcca cgacagttta caaatgccac ggcaacgtca ggaagttgcc ctatattgtc 360 taaaaggagg aggaattctc ggttccggga actgcccacc ccttacccgg aaactcatga 420 ataatccacc ccttgtttag catgtaatca ggaaataact ataagtatat tcagttgagc 480 agcccatgcc gctgctctgc ctatagagta ggttttcttt ttttgagatg gagtctcgct 540 ctgttgccca ggctggagtg catttttgca accttgggtc actgcaacct ctgcctcctg 600 ggttcgggag attctcctgc ctcagcctcc cgactagctg ggactacaga catgtgccac 660 caggcccagc tactttttgt atttttagta gagacagggt tttgccatgt tggccaggct 720 ggtctcgagc tcctgacctc aagtgatccg cctgcctcgg cctccctagg tgctgggatt 780 acaggcgcga gccactgcgt gtggcccaaa ttctttcttg cttgagatct aagaaccctc 840 tcttgggatc t ggatcgggt cccctttctg gcaacagagt cacctccttc aagaggccct 900 gatgtcctca gcaggtcgct aagggcctgt ctagctccct gaggcccaaa cactgtgcca 960 ttttgacagc caggggcccc aggtccatct tgaggctgtg aacatgctgg ctgtccaggg 1020 gtctgtgagc tggtatcagg ggagggtggg gcagcaaagt gaagccgctc ccagggcaga 1080 agcctccatg cccacatccg ggaaatcttc ctctcggagg ccctgcctgg gaggcatctg 1140 caggcgctcc cccgctcata gaaggtctgc tcatccagcc cacccctgaa gtcactatca 1200 ggcagggggt agggcaggcc atggggacct acctgccctc catgcattcc aaagaatcga 1260 agtcctccat agggtccagg tcctcttcag agtcagtcat gccaagaacc tccatggtcg 1320 ggggttccag gagctgctca tacaggaggg tctccatcaa gatgtctctg gagaggggtc 1380 ttacttcaga catttctcct ctggggcaaa aagacagcat atgactggac ccctaagaac 1440 tgagcagtct gggggctctc tcacaggatg acccccagat tgtatagccc tactcaccag 1500 ctcttttgat ccgctaaagc cgtcaatatc ccccaacccc agctcccaca ggcatgaatc 1560 ctgctacatg ctggctgtgt gcctctgggc aagtcgccta gcatctctgt tcttggaagg 1620 gaggaacttg aagatgattc ataagggccc tttctttctt tctttgtttt tggatactga 1680 gtcttgctgg aggctgga gg gcagtggcac aatcttggct cactgcaacc tctgcctcct 1740 gggttcaagc gattctcctg cctcagcctc ccgagtagct gggactacag gcatgagcta 1800 tgcctggcta attattttgt atttttagta aagacggggg tttcatcatg ttggccaggc 1860 tggtcttgaa ctcctgacct caaagtgatc caccccacct cggcctccca aagtactggg 1920 attacagcac tttggattaa tttattaaat acccattacc ctctaccaca aagaagggac 1980 ctaatctgaa cctttaacca tctggcctct gggcccaggc cctcagattg acttgatatg 2040 aatggcaaag atcccatcac caactgggcc tag gct ggc ctt agg gcc cag atc 2094 Ala Gly Leu Arg Ala Gln Ile 1 5 tgc atg gga aaa gtg tgg agc cag gga gtg gaa ggt ggg gag cct gcc 2142 Cys Met Gly Lys Val Trp Ser Gln Gly Val Glu Gly Gly Glu Pro Ala 10 15 20 cag gag ggt cct tgc agc agc gac ctc ctg ctc tgg tct ctc ctg gcc 2190 Gln Glu Gly Pro Cys Ser Ser Asp Leu Leu Leu Trp Ser Leu Leu Ala 25 30 35 acc cca cca gcc caa ggg agg ccc agt cct gtc agc gcc tac 2238 Thr Pro Pro Ala Gln Gly Arg Pro Ser Pro Val Ser Ser Tyr Leu Ala 40 45 50 55 cca gct ctg aat gcc tta ctg gtc tcc agc ctt cag tgg agc tct ct c 2286 Pro Ala Leu Asn Ala Leu Leu Val Ser Ser Leu Gln Trp Ser Ser Leu 60 65 70 caa cct aat ctc aag gta gca gcc tca acc ctg acc ctg tca ctg ctc 2334 Gln Pro Asn Leu Lys Val Ala Ala Ser Thr Leu Thr Leu Ser Leu Leu 75 80 85 tgt tcg gct ccc tagacctggc ctggtgcagt gcggctcatg cctgtaatcc 2386 Cys Ser Ala Pro 90 cagcactttg agaggtggag gcgggtggat cacctgagct taggagtttg agactagcct 2446 ggctaacatg gtgaaacgcc atctccgctg aaaatgcaaa aattaaccag gtgtggtggc 2506 gctcgcctgt aatcccagct acttgggagg ctggggcggg agaatcactt gaatccggga 2566 ggcagaatat gcagtgagcc gagaccgcgc cactgcactc caacctgggt gacagagcga 2626 gacttgtctc aaaaacaagt ggggggttgt gccacatcca ctaacaggcc ctccccctgt 2686 ggccctgcca ccccaatctt ggttcccgct ctaaccacac tcaagtatgc tttccatgga 2746 tggtgcctgg tcctgccatg cctccaaagt cttcaaatgt gcagccaacc tcagaccggc 2806 ccatgcctac acctattggt ccttttttaa aaattaaatt ttattattat ttttttcaca 2866 gacagggtct cacccgtttg cccgggctgg agtgcagtgg cctgatcatg ctcactgcag 2926 cctcaaactc ctgggctcag gtggtcatcc cacctcagcc tccagggtaa ctcgacaggt 2986 atgtaccact gcacttggct catttttata gaattgctgt agagataggg tcttgctttg 3046 ttgcccaggc ttgtctcgga actcctggct tcaactcccg cctgggcctc ccaaagtact 3106 gagaggatgg gtatgaggct ggcctattca ggcatcacct tcttggaccc tcagagtctg 3166 cttgggggcc tcctgggggt cctgcagccc ctgtctctgc tcccctctgg ctccagctga 3226 ccactgcact ccaggctggg ctacagggca agactccata tcagaaaaaa aaaaaattag 3286 aatggagata ctagtaacac ctattgcaca ggactgttgt ggggatgaaa tgatccggca 3346 cagagtaaac cgctaagaga ggggctgctg ctcttatcag tttctggttg tcagcccaag 3406 gcctggcata gagcagacat atgtttgttg actgaagaca tgaaggcaac ctattcccag 3466 aggacccact gtgaggtcac tgcagctgca gatccaggaa actggactgg tttttattat 3526 cttttttttt ccagcaaact tgcaaatgag tagttgaaac ccttctttgg tgaaggaaga 3586 cacacctagc catgtgtccc cacccaggct acagcccgca cttagcctcc tacacactca 3646 ccagtggaaa caccaggcgc cagtcagaag ccctatttta ccctaagagg ttaggatgca 3706 aatctagtat gtgcagaaaa gagtgccaca cccacggcct tgagggcacc tgcagggctc 3766 cgagtgggag ggagggcagg ttctggacag agcagcctac atttggtgaa cagct ctgca 3826 ctcgacagct cgcctatggc tcatctggaa gatggggaaa cgccatctac ctcccaagcc 3886 cctcccaggt tgcccagaag cacaagcaag tagagatgtg ttctgctcag ccctcagcag 3946 gtgttcaagg gccgaggctg caggagtgtc agagcggggt tgggggcaga ggtggatggg 4006 gctggacctg aggatgaggt cgaactcctg gtagggaccc tcagactctc atgacctcgc 4066 ccagtcctgt caaagccaag caggcgggat ctgacacttc ctgtttcaca ggcaggcaaa 4126 ccgagagggt caggggccac gctggggtca cagggagggc cagctgagtg ggcccagcta 4186 gaaaaccctg gtccagtctt ccacgtgcca ccctcccagt cacagcctgg ccctggacca 4246 tgagggtggg gtggcacaaa gcccttggag cgcacacaac tccagtgtaa cccagcagga 4306 aacgccctga gcctgcagcc aggctggacc tcagttccac cccctgctcg gcccctgctg 4366 tgtgaggcag aacaaccagc tcacctctga gccttgcaga aacagccggg cctccagggc 4426 tgctgagagg atgaaaacat acactactgc ccattttcca ccacctagca ggggctccat 4486 aaaagctggt taacacaatc aacagcctta gaagagagga gaccagaggc cactcacagc 4546 tcaggacgcc acggtggact gaacatgttg ctgcctttct ggagggtagt gtgaccatca 4606 gcatccacca gtcacacacg cacatgacct ttgatttcta gggatgcatc ccacacacac 4666 ccctgcatgg acctggcagc cttgaaaaat tgaagccata gatcacaggc accgctgtgc 4726 tgtcatcaca gcccttcggg aggccgaggc gggcacgtcg cacgagccca gttcaagacc 4786 agcctgggca atacaacgag accccctctc taaaaataaa ttaacaataa aaaattttaa 4846 aaatatatga aatgggccag ccgcggtggc ttacacctgt aatcccagca ctttgggagg 4906 ccaaggtggg cagatcatga ggtcaggagt tcaagaccag cctgactaac atggtaataa 4966 aactccgtct ctaccccgtt tcaaaaaaaa ttagccaggt gtggtggtgc gcgcctgtaa 5026 tccagctact cgggtggctg aggcaggaga atcgcttgaa cctgggagga ggagtttgca 5086 gtgagccgag atcacaccat tacactccaa cctgggcgac aagagcgaaa aactccatct 5146 c 5147 <210> 50 <211> 5161 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3272) .. (3769) <400> 50 caagtagtag aagaacgaaa gcaaatgaag ggaaaaaaga aacatgggat acagcagaag 60 aagactctgg aactgatagt gaatatgatg agagtggcaa gagtagggga gaaatgcagt 120 acatgtattt caaagctgaa ccttatgctg cagatgaagg ttctggggaa ggacataaat 180 ggttgatggt gcatgttgat aaaagaatta ctctggcagc tttcaaacaa catttagagc 240 cctttgttgg agttttgtcc tctcacttca aggtctttcg agtgtatgcc agcaatcaag 300 agtttgagag cgtccggctg aatgagacac tttcatcatt ttctgatgac aataaggttg 360 attaaaataa tcttcgagta gttagagtct attttaaatg atagatttga gaacagcttt 420 tactacttcc aagtgaggtg aagtagataa actggaagga ttttttttta atgattaatg 480 gtaatttggg gggttttttg ttgttatttt tcttcactca tctaacaaac atttgtgaaa 540 tgttagctgt gtgtcagtta ctattctagg tgctggggat tcagaggtaa aagatatgcc 600 tgttctcaga gagcctataa tctagagtat tttggaaagt ttaaaaatgg gatgagaatg 660 ggttgtttat tctgctgaga cagcatgtct aaaaaaatgt ttttaactta tagattacaa 720 ttagactggg gagagcactt aaaaaaggag aatacagagt taaagtatac cagcttttgg 780 tcaatgaaca agagccatgc aagtttctgc tagatgctgt gtttgctaaa ggaatgactg 840 tacggcaatc a aaagaggaa ttaattcctc agctcaggga gcaatgtggt ttagagctca 900 gtattgacag gtttcgtcta aggaaaaaaa catggaagaa tcctggcact gtctttttgg 960 attatcatat ttatgaagaa gatattaata tttccagcaa ctgggaggtt ttccttgaag 1020 ttcttgatgg tattttcaat atttttgggg ggaagtatca gttagaaata ctctagaact 1080 aatagaagcc tatagttttt aatcaaataa tgagttacga ggaatctaat atacattata 1140 gtgttttgtg ttatattaag cataacgata tccttattat ggattgatgt gattcctacc 1200 tacgtcttat ccttgggagt tttattttct tcccctgtgt cctaatgtaa ctgcttaagt 1260 tgtttttgaa agaataatca gtgtctttca gccttctgct atctttctct ggttcccatt 1320 tgccttttaa gtattctttt tttgaatgtt gagaatatta attccccctt atgaggaaat 1380 tacaaagtta ggtttttaat acattttaag aaaactctgc taatattttc ttagccacgt 1440 ttgttcttta gtttcttttt tactattatg gcttattttg tattgaagac atggtactga 1500 taatttatca gagactcaag aacaatgact atttgtgtcc taagccaggt ggcttaaaga 1560 atagaagtgt attgtctcac aatctgagat caggctgtca acagggttgg ttccttctga 1620 gtgctgtggg ggagaatctg ttccatactc tctcctagct tctgtggttt ttggccatca 1680 ttggcaacct tggcttgt ag atacatcacc ccagtctctg ccttcatctt catgtggtgt 1740 tctttctgtg ggcttgtctg tctgtattgt tttccccttt ttcataaacc actagtccta 1800 ttgtattagg gcccaccctg aagaccttat tttactttga gtatcactgg aaagacccta 1860 tttccaaata aggtcacatt ctgaggtact agggattagg atttcaaaat gtctttttgt 1920 ggggggcaca attcaaccca tagcagtgac cttgaggagg tccaagtagc agacatactt 1980 gtcacacctc ccagttttcg ttatcaacat tggcacattt aaagtattgg tgtttggagg 2040 gaggcttata ggaggaaagt tggcttttag aagatcacat caaggtaaac aactagttct 2100 atattctttt tttgctgttg cttaggaaaa ttttaatttt ccttttcttc tgtagaaagt 2160 aaaatatgaa ttctggatat tttgttacaa gattatccta gtttttagag agctcaataa 2220 tactaacacc tcatgtattt caggctgctt caggtctaat tcaaccataa atttaaatgg 2280 ttgaaattct gattaattga caagttaagt tgggaggtaa ggaacaacta ggataccatc 2340 tactatggtg tgtaggcaag tgctccagat tgtgatttct ttgagtatct ggggtcgtag 2400 ggaataatca ctgtgcctgg gtaagtcagg aagagatcat aaatgacaaa gaagtcaccc 2460 ttgtaaggat tgagtatgta ttagcagaga tggattcatc tgaaaatggt actagatggt 2520 gggtgcctgc atcagtatta ttt cagtata ttttcacatc aagatagttg agtaagaaat 2580 gtcatgtgat taaatccaag aggtatttat tgacctgtaa tttgccagac actgctaatc 2640 ccttgtgcta caaaaatgag taagaaccac ttattggtgc acacagtctg tggaagaaac 2700 agaactgcaa acctgtcatt ctaaaataat aggtactaag ggactgaatc agtagaagtt 2760 cttcttgtgt acaccagaga aaagtgacaa ttgagttgat gcttgaaaag tgacaattga 2820 gttgatgctt gaaaagtgac ataatggaaa agtgacaatt ttgaagaatc actaaattgg 2880 ggagtaaatg gaaagagaag gattaataat agctttagtg aaaaaagagg ataaagtgaa 2940 gttgatttgt ttatgatttt agatagggat aggagccaat agagaaacaa agattggaaa 3000 tccagagaag agagtaattg gtaatgcagt gttcaacagg agtcaggagg gagtggaatt 3060 aggagtactg gtttgaagaa gagaggaatt atcttctgag actggagaga agagagtaaa 3120 tatttcattc tcaaaaactc cttgggataa ttgggttttt tcttgtgccc actttttaag 3180 agtaacactt gaagtaaatc tttttgttta gtaaggcact aagggaaaag tcaaattatg 3240 aaccttcaga ggaaatagaa tgatgaccta a tct tgc ata ttc tta ggg gta 3292 Ser Cys Ile Phe Leu Gly Val 1 5 gag aag atg aag tcc atg tca cag ctt gca gtt ttg tca aga cgg tgg 3340 Glu Lys Met Lys Ser Met Ser Gln Leu Ala Val Leu Ser Arg Arg Trp 10 15 20 aag cct tca gag atg aag ttg gat ccc ttc cag gag gtt gta ttg gaa 3388 Lys Pro Ser Glu Met Lys Leu Asp Pro Phe Gln Glu Val Val Leu Glu 25 30 35 agc agt agt gtg gac gaa ttg cga gag aag ctt agt gaa atc agt ggg 3436 Ser Ser Ser Val Asp Glu Leu Arg Glu Lys Leu Ser Glu Ile Ser Gly 40 45 50 55 att cct ttg gat gat act gaa ttt gct aag ggt aga gga aca ttt ccc 3484 Ile Pro Leu Asp Asp Thr Glu Phe Ala Lys Gly Arg Gly Thr Phe Pro 60 65 70 tgt gat att tct gtc ctt gat att cat cag gat tta gac tgg aat cct 3532 Cys Asp Ile Ser Val Leu Asp Ile His Gln Asp Leu Asp Trp Asn Pro 75 80 85 aaa gtt tct acc ctg aat gtc tgg cct ctt tat atc tgt gat gat ggt 3580 Lys Val Ser Thr Leu Asn Val Trp Pro Leu Tyr Ile Cys Asp Asp Gly 90 95 100 gcg gtc ata ttt tat agg gat aaa aca gaa gaa tta atg gaa ttg aca 3628 Ala Val Ile Phe Tyr Arg Asp Lys Thr Glu Glu Leu Met Glu Leu Thr 105 110 115 gat gag caa aga aat gaa ctg atg aaa gaa ag aaa gaa gac ag cag 3676 A sp Glu Gln Arg Asn Glu Leu Met Lys Lys Glu Ser Ser Arg Leu Gln 120 125 130 135 aag act gga cat cgt gta aca tac tca cct cgt aaa gag aaa gca cta 3724 Lys Thr Gly His Arg Val Thr Tyr Ser Pro Arg Lys Glu Lys Ala Leu 140 145 150 aaa ata tat ctg gat gga gca cca aat aaa gat ctg act caa gac 3769 Lys Ile Tyr Leu Asp Gly Ala Pro Asn Lys Asp Leu Thr Gln Asp 155 160 165 tgactctgat agtgtagcat tttccgg ggtgg ggtgg ggtgg ggtgg ggtgg ggttgg tggttggggt aacccagtga caccagcact 3889 gattggactg ccctacacca atcagaagct cagtgcccaa tgggccactg ttttgactcg 3949 gaatcatgtt gtgcactata gtcaaatgta ctgtaaagtg aaaagggatg tgcaaaaaaa 4009 taaaaaaaaa caacaaaaaa agctaacctt ctattagaaa aggggacagg ggaatgagta 4069 aacttctttt attgcggaca aatgtgcaca tagccgctag taaaactagc ctcaaacagg 4129 atgctcatag cttaataata aaagctgtgc aaaggccatg aatgaatgaa ttttctgttt 4189 atttcactga tgcacacatt acctcattga caattcagaa gtaaatccaa cgtgtgttga 4249 ctcttggaaa gcagcaaaaa caggagctga agaaaagaaa ttcttggaac cagccgtaac 4309 ccagtaagga attgtgaagt tgtgttttta ttttgtttca ttttttgcag agtattaaga 4369 acattattct ggaacatcag aacgtttccc ttagaccgat cccagcaggt ggcagctcag 4429 attgctgcag tgttgtaatt ataactgatt gtacttaagt tatggatgta gagaatatgt 4489 ttcattcatt tattcagcat gtaaataaaa ttgatcctgt tgagttatca taattgcagt 4549 tcaactatct gccatgatta ttcttttcac gtatcattca ttctgtacat ttgtgtacat 4609 tgagaagtat agcaatctat gtaaatgtaa tcctcagtga ggttcctcag tgctaggtcc 4669 cataggattg tcgttgccct tgttaatgag gtttctctgt tcagcggctt caattttttt 4729 ctctttgtac atctagtttt gaagatttac ttcaagtttg aatcttctag aatgcttgta 4789 agtccagttt taatttttag agtcaatttg tagttacatg tagtttaact tttgggaaac 4849 gtcttaacat tgttctgaat aaacttgcta atgaggtcag gtcatggtac agactgatgc 4909 agtcaacatg atttcattgc agagtttatt agtatcagca agtttttgct ttgctaaata 4969 aaagtactca atgaacacaa ttctacataa attttgacat accatctaat ttataaaaat 5029 caataaaaaa ggttttggta aaactttttc atgccagatg ctgtttacaa caatgaacat 5089 gccaataaaa catttgttca ttctgttgtg ttattttagt cattaaactt ctgtggatga 5149 agaa tctggg tt 5161 <210> 51 <211> 5581 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (610) <400> 51 c cgg acg gct gtg cct gac ctt gac cgc gag agc cag gag cgc tac gag 49 Arg Thr Ala Val Pro Asp Leu Asp Arg Glu Ser Gln Glu Arg Tyr Glu 1 5 10 15 gtg gtg atc cag gcc aca gac atg gcg ggt cag ctg ggt ggc ctc tcg 97 Val Val Ile Gln Ala Thr Asp Met Ala Gly Gln Leu Gly Gly Leu Ser 20 25 30 ggc tcc act acc gtc acc atc gta gtc acc gac gtc aat gac aac ccg 145 Gly Ser Thr Thr Val Thr Ile Val Val Thr Asp Val Asn Asp Asn Pro 35 40 45 ccc cgt ttc ccg cag aag atg tac cag ttc agc atc cag gag tca gcc 193 Pro Arg Phe Pro Gln Lys Met Tyr Gln Phe Ser Ile Gln Glu Ser Ala 50 55 60 ccc att gga acg gct gtg gga cgt gtg aag gct gag gac tca gac gtg 241 Pro Ile Gly Thr Ala Val Gly Arg Val Lys Ala Glu Asp Ser Asp Val 65 70 75 80 gga gag aac aca gac atg act tac cac ctt aag gac gag agc agc agc 289 Gly Glu Asn Thr Asp Met Thr Tyr His Leu Lys Asp Glu Ser Ser Ser 85 90 95 ggc ggc gat gtg ttc aag gtc acc aca gac agc gac act cag gag gcc 337 Gly Gly Asp Val Phe Lys Val Thr Thr Asp Ser Asp Thr Gln Glu Ala 100 105 1 10 atc atc gta gtg cag aag cgc ctg gac ttc gaa tcc cag ccc gtg cac 385 Ile Ile Val Val Gln Lys Arg Leu Asp Phe Glu Ser Gln Pro Val His 115 120 125 acc gtg atc ctg gag gcc ctc aac aag ttc gtg gc cgc ttc gcc 433 Thr Val Ile Leu Glu Ala Leu Asn Lys Phe Val Asp Pro Arg Phe Ala 130 135 140 gac ctg ggc acg ttc cgc gac cag gcg atc gtg cgc gtg gcc gtg acc 481 Asp Leu Gly Thr Phe Arg Asp Gln Val Arg Val Ala Val Thr 145 150 155 160 gac gtg gac gag ccc ccc gag ttc cgg ccg ccc tcc ggc ctc ctg gag 529 Asp Val Asp Glu Pro Pro Glu Phe Arg Pro Pro Ser Gly Leu Leu Glu 165 170 175 gtg cag gag gac gcg cag gtg ggc tcc ctg gtc ggc gtg gtg acg gcg 577 Val Gln Glu Asp Ala Gln Val Gly Ser Leu Val Gly Val Val Thr Ala 180 185 190 cgg gac ccc gac gcc gcc aac cgg ccc gtc cgg tgagaccccc Ascgcccc Asccc Pro Ala Ala Asn Arg Pro Val Arg 195 200 gacgcctgct gcctgctatc ccgccatcac ccccgcggac agactgcggg cagaggggag 690 gagggctggg gcgggcaggg ccgaaggaag gggctgcgtg ggggagggag gcggggagc750 gtggagagaa acaggcacgg agccaaagag ccaaggaagc agatgtgaga 810 acagtcaatg agacaggcag gcgagccagg ccaataaggg agagaaccag gagggacaga 870 cacagaggcg ggcactgcac tggcggggtc tccgcgctgc tggctgcagc cacactggct 930 ccctgatctc tcgactgggc catccctgtg cccaggactc ccccagtctt ctccctgcac 990 ccccttccct ctcatcatct cccttggtgt tccgctagac acctcaaact taagttcaga 1050 actgggttcc tggtctctcc atcaaaagaa aaaaaaaacc caccagtttg cctgccgtta 1110 tctccatctt gggaatgaca gctctatcct tccagttgtt taggttaaaa acgttggagg 1170 catccttgcc tcctctcatt ctctcatgcc tcccttcaat ccattagcga attctgctgt 1230 ctctacctta aaaatggatc cagaatctga ccacttctca ccacctctgc tgctaccacc 1290 ttggtcccga ccaccgtttt ctcttgcctg gagtattgca gttgcctcct tgctggtgtc 1350 cctgattctg tcctcacccc tctttaacct agaattgttg caggagccag cctgatcctg 1410 ctcaaatgtg aactagagcc tggccctgct ctgcccaagc cctccaaaga cacctactag 1470 gctcagaata aaagcccaag cccttacaat gacagctctg gcctccctga acctctcaga 1530 ccacacctcc ctctcctttc cagtccactc tgctgcaacc acactggccc cctcacagcc 1590 ttgcaaacac accacgctc a tctgcactct gggcctgtgc tacagcggat ccctcggcct 1650 agaacgttct cgccctaata gcccccatag ttcgctctct cacttcctcc aggtctttgc 1710 tcaaaagtca tcttctcagt gagaccttct ctggccactc ttcctaaaat ttcaactcca 1770 ccccaaccct tagccctgac tcttcctatc ccctgtcttc ctctgctgct tccttattac 1830 ctttcatcac catctgacat gctacctgct tttctgatta ccttttttgt ctcctactga 1890 aaggtaagct gtctgagggt agggatttac gtctatttgt tcaccactat acccataggg 1950 cctagcccag gcctcagcac tcagtggaca cgtgctgaat atgtggtgaa ttaatgatat 2010 gtaaaaatag aggccgggtg tggtggctca tgcctgtaat cccagcactt tgggaggccg 2070 aggcgggcag atcacccgag gtcaggagtt tgagaccagc ctgaccaaca tggtgaaacc 2130 ccgtctctac taaaaataca aaattagccg ggtgtggtag cgcacacctg tagtcacagc 2190 tactctggag gctgaggcag gagaatcgct tgaacccgga ggcaggggtt gcagtgagcc 2250 gagattgcac cattgcactc tagcctgggc aacgagagca aaactgtctc aaaataaata 2310 aattaattaa ttaattaaaa taaactaaaa aaataaaaat aaagactgaa aaaagaggca 2370 gaaaaacaga ctcacagaga tgtagagaga ccaacaatga gaggaagaga ctggagagaa 2430 agaaaagccc ataaaaagag gaca ggaggg actgacctgg caatgtggaa acagaagggc 2490 accttggaga ggaaaccaga aaagggaaga aatagacaca gacacaggca agccagaggc 2550 agagcaggga tggggcagct ggggtccctg gaagggtctg ggagctgtaa gtattgggga 2610 gtctctgaca gtagcctagg ctggaagatg ttcagataga agagggaaga aaggctgtag 2670 aagaaactga tccagaggag gaggttaggg gctgggggga tggccagtgt tagagggatg 2730 ggaaggaggc actggggctc cctgattcat tcccaaaacc cctgtaccta ttcaatgagt 2790 aacccctgag ctgactatga gcctagccct gtgctgggca ttgaggagag ggggagggaa 2850 agtttatttg aggacctctg cattgtgcaa ctccagaggg caacgttccg tcattgtctg 2910 tctgaatggc tctatcagga ttgtgcagtg cacagcctgt tcaaccttac atggcagccc 2970 taagtgagac acacagatgc tatcctgctt aactgttcat ggattctcag actgggagat 3030 agccccagga gtctgggaag acttctgaag gaggcaggaa ttgacctgac ctaggtatct 3090 gggtatggtg taaatatcag gagaggcaca ttccagacag acgaacagct tgtgcagagg 3150 tatacaggca gaggagtggt tggtgtgcct gaagaagagc agactgtgat cgctacaggg 3210 ggctgggaaa gatgaggcac aaaagtgaag tctaacaggg cctcagaggc aggctgagga 3270 gctcagactc tgtcctgaag ccgagaatg c ccacgctact ttcactacac tcgctgccaa 3330 tgccatcctg tcactgcctc tgaactcctc cactcccttc cacccgggct ggtggcatag 3390 tctctgaaca acccccttgg cctctggcct gggcccagac ctctccagga agggcactgt 3450 cacctctgtt tgtctgggag ttgaggccca gggaggggag gaggattctg caggctctcc 3510 cagggaggta agaacacgga gcgggaggcg agtccttggc cccaggtcag tcctcccatc 3570 tgccagctcc cctcctctcc aattccactc tccacacccc ctctcagtcc tcttcctcct 3630 ccccgctttg gctcccttcc ctcctgcttt tatctgcact gaaagggcca actttgaaac 3690 ctacttctca ccttctttca tctctctttg ccggcccctt ccctggggct cctcagatgt 3750 ggaggcagtg aggagctgga gactggtcca atttaacacc acaaacattt acccagctcc 3810 tcctccatgc caggccctga gccaggcctg gggacaccaa gatgactcag ccaaggacag 3870 aactggggtg gagctcccag actgtggggt acaaaaatgg aaatgggagg ccattgaggg 3930 tctgtgggag acagagaagg ggtcctcaca ggccatgtgt gctgccagag tccagctcgc 3990 tctaagggtt ccattctggc agcacctgcg ttctcagggt cacaggctta ggcagcaact 4050 ccgcattgag ttgtgcccgg cactgttctg tgcagtgagg aagcagagat gataaaacag 4110 gatccctgcc cacgtggagt ttgccttctc ctgc agagag acagacagca aatggttaaa 4170 tggaataact gctgaaagca ctatgaagaa aatagagtga taggataagg agggattggg 4230 gccacagagg gccactttga attgagtggt cagggatgtg acacatgagc tgagatcaga 4290 atgatgggga gccatccatg caaaaatgtg aggaaaagca ttccaggtag agggaacagc 4350 aagcagaatg gccctgaggc aggaacaagc ttggcgtgtc cctggaaatg aagacatgag 4410 gtggcatcct gggagacttt gcctagcatg gtttgcaggg cacagtgagt gcctggaaat 4470 tataggaaag cagacagtac agagagattt tttcttagca tctgcactgg agatagtaga 4530 aggtgcctca tgttactaca tttacccttc agaggtattg tactcatttg acagacgaag 4590 aaactgagag tcagagaggg gaaatgactt cccaaagcca cccagctcaa aaggggaagc 4650 accggggttt gacccatgac tcaccacttc ctgaatccag cctttggcca tttcactcct 4710 gcttcttact ctccttgtgg ttagtgcagt tcctaaactg gtgcagcgtc ctcccctgtg 4770 cactggccac agagatgatg gcctcagaca tgggccagtg ggaaagcttg gcccgtgtga 4830 acgaatccag tgacaggtcc aggtccaagt gggcttgggc tgaggcaggg gcttgaggag 4890 ctccagggag gggtgagtag tttatgcacc aggaagggga gtgacagagg tttgccccaa 4950 aaggcccctg caaggggacg aagaggacaa ggcttggaa t ggggagagtg tgccccaggt 5010 tggagtgatg gggaggagag atggcaggga cagaatcatg gagccaggag gttaagttca 5070 ggagcagcga gaccagctgg acaagctcac gacaagggac aagggagcac ttggagacag 5130 gctgcgaagg acattgaatg ccacatgaag aagtgggact ttatcctcta ggcagtggga 5190 agccttagaa ggcttgagaa ggaggcagga aagtgctcag atgggcccac ctctcagtta 5250 ggcaggtttg cagatagact ggccatttat cagcccagcc acgttcctac ctagccccat 5310 tgtgagtctc ctttgatcat caaaaacagc tagtccacac tgcagcagag gaagcgaaca 5370 cttcctttct ccacccagca ctccacagtg tggtgcagca gaaactgcaa gggctttgaa 5430 atcagaggag acctgggttc aaatcccagc tcagttgtgg agtcttgggc aagtcaatgc 5490 accccctctg agcctcggtt tccccatctc taaaatagac atcataatag tatgtgcctc 5550 attcataggcatta <210> 52 <211> 5213 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1248) .. (4820) <400> 52 cgggcccccc ctcggtgggg ggtcgcggaa agcggagagg tcagggccct gccgttcgcc 60 catccgggcc tcgacttccc tcctccggcc cccaggctgc cgaggggcca ccgggcaggg 120 gtgggcaggg cctggggccg gagtcagcgc ggactgctag gtgggggcgc cggccgggcg 180 ggggagggag ggaaggaggg gcgcgcgtgt ctgcgctttt ggaggaaaca gtcccacctc 240 gtcctttgcc gtccccattg ctgagcatga ccgggccctg acacctggtg cagaagggtc 300 cctgggcaca gcagaccccg gggggacccg ccgccagaac caggggatct cgctcctccc 360 tcttggggca gccataagcc taggagctcc tgacgctgtc cgggccccgc ggctccccgc 420 gctctctagg ggagagcctt ggggcgtatc cggggtcgcg ctcaccctcc cgcgccgccc 480 cctgcacggg ctcggagctc ccgagtgctg ggagggcttc cgggcggcgg cgagcggcgg 540 ggggcggtgt caggaggccc ggccaggccc cgccccctcg tccgccctcc ctccctccct 600 gcgcacccgg ctcgggtccc cgggctcgcg gctgcggctt ctgctcaggg aggcggaagg 660 cggcggcggg agcggtcatg gaggcgggcg ccggagccgg cgcgggagcc gcgggctgga 720 gctgcccggg cccaggtcag agccgcccct ccgtcacctg tctaccgccc ctcctttctc 780 tcctccatcc ctcctccttc cagaccccca ggtgctcccg gcctccgcgg ctcccctttc 840 tccgcccaaa gtcttcctcc ctccatcctg gcctccaccg gggcccggtc tccatccttc 900 cggcctggga ctgaggcttc cgcgcaccgg ccgcatcctg cctggtggtc cctccccagc 960 gcgtctctcc acttcagtcc gacggtgctt ccagccttcg ggactgcaga ccctacacct 1020 cctgcagccc cggagactcc tgagcgcggg gcgagggtgg ggtgggcaag gtccagcgag 1080 agaatgggag gagaggggag gggagcggtc gcagccctac cccttcccgc acgcccccca 1140 ctcctccctc cctccatctg taggccacct cagcctttca gcctcttctt cactggctcc 1200 cgccctcttt cagtcttggc cctctcctcc ctgtcccccc ggactaa ata cgc aca 1256 Ile Arg Thr 1 ccc cct ctt tct ttc tgt gca agc aag agg gtc ctg gaa cag cgg gtt 1304 Pro Pro Leu Ser Phe Cys Ala Ser Lys Arg Val Leu Glu Gln Arg Val 5 10 15 ctg agg agg ctg gga ggc agg gct gag tgg ccg aga gag agg agt 1352 Leu Arg Arg Leu Gly Gly Arg Ala Glu Arg Trp Pro Arg Glu Arg Ser 20 25 30 35 cgc aga gcc gcc aga gtg agt cag gca cct cca ctg gga tta cag atc 1400 Arg Arg Ala Ala Arg Val Ser Gln Ala Pro Pro Leu Gly Leu Gln Ile 40 45 50 cca gag cct cga gga gct gga aga cat gtc ccc ttc ttt cct ctg cac 1448 Pro Gl u Pro Arg Gly Ala Gly Arg His Val Pro Phe Phe Pro Leu His 55 60 65 ccc agc ccg cag cca gcc ccc cac ccc cca gcc cct cct ttc tcc ctg 1496 Pro Ser Pro Gln Pro Ala Pro His Pro Pro Ala Pro Pro Phe Ser Leu 70 75 80 ctc tca gga ccc aca gtg acc act cta ggc tcc tat gag gct tcc gag 1544 Leu Ser Gly Pro Thr Val Thr Thr Leu Gly Ser Tyr Glu Ala Ser Glu 85 90 95 ggc tgt gag agg aag aag ggc caa cgc tgg ggg tcc ctg gaa cga cgg 1592 Gly Cys Glu Arg Lys Lys Gly Gln Arg Trp Gly Ser Leu Glu Arg Arg 100 105 110 115 ggg atg caa gct atg gag ggg gag gtg tta ctc cca gct ctc tat gag 1640 Gly Met Gln Ala Gly Glu Val Leu Leu Pro Ala Leu Tyr Glu 120 125 130 gag gaa gag gaa gag gaa gag gag gaa gaa gag gtg gaa gaa gaa gaa 1688 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Glu Glu Glu 135 caa gtg cag aaa ggt ggc agt gtt ggc tct ctg tca gtc aac aag 1736 Glu Gln Val Gln Lys Gly Gly Ser Val Gly Ser Leu Ser Val Asn Lys 150 155 160 cac cgg gga ctg agc ctc acg gag aca gag ctg gag gag gct 1 784 His Arg Gly Leu Ser Leu Thr Glu Thr Glu Leu Glu Glu Leu Arg Ala 165 170 175 cag gtg ctg cag ctg gtg gca gaa ctg gag gag acc cgg gaa ctg gca 1832 Gln Val Leu Gln Leu Val Ala Glu Leuglu Glu Ar Thr Glu Leu Ala 180 185 190 195 ggg cag cat gag gat gac tcc ttg gag cta cag ggg ctc ctg gag gat 1880 Gly Gln His Glu Asp Asp Ser Leu Glu Leu Gln Gly Leu Leu Glu Asp 200 205 210 gaa cgg cta gcc agc gcc cag cag gca gag gtg ttc acc aag cag atc 1928 Glu Arg Leu Ala Ser Ala Gln Gln Ala Glu Val Phe Thr Lys Gln Ile 215 220 225 cag cag ctc caa ggt gag ctg cgt tct cta cgg gag gag att tcc ctg 1976 Gln Gln Le Gly Glu Leu Arg Ser Leu Arg Glu Glu Ile Ser Leu 230 235 240 tta gag cat gag aaa gaa agc gaa ctt aag gaa ata gaa cag gaa ttg 2024 Leu Glu His Glu Lys Glu Ser Glu Leu Lys Glu Ile Glu Gln Glu Leu 245 255 cat ttg gcc cag gct gag atc cag agt ctg cgg caa gca gca gag gat 2072 His Leu Ala Gln Ala Glu Ile Gln Ser Leu Arg Gln Ala Ala Gla Asp 260 265 270 275 275 tcc gca act gaa cat gag agt gac ata gca tc c ctg cag gag gat ctc 2120 Ser Ala Thr Glu His Glu Ser Asp Ile Ala Ser Leu Gln Glu Asp Leu 280 285 290 tgc cgg atg cag aat gaa ctt gaa gac atg gaa cgc att cgg gga gat 2168 Cys Arg Met Gln Asn Glu Asp Met Glu Arg Ile Arg Gly Asp 295 300 305 tat gag atg gag atc gcc tcc ctc cgt gca gaa atg gaa atg aag agc 2216 Tyr Glu Met Glu Ile Ala Ser Leu Arg Ala Glu Met Glu Met Lys Ser 310 315 320 t cca tcc ggt agt tta ggt ctc tca gat tac tct ggg tta caa 2264 Ser Glu Pro Ser Gly Ser Leu Gly Leu Ser Asp Tyr Ser Gly Leu Gln 325 330 335 gaa gaa ctg cag gag ctg cgg gaa cgc tac cat ttc ctg ag 2312 Glu Glu Leu Gln Glu Leu Arg Glu Arg Tyr His Phe Leu Asn Glu Glu 340 345 350 355 tac cgg gcc ctg cag gag agc aac agc agc ctc acg ggg cag ctt gca 2360 Tyr Arg Ala Leu Gln Glu Ser Asn Ser Le Gly Gln Leu Ala 360 365 370 gat ctg gag agt gag agg aca cag aga gca aca gag aga tgg ctg cag 2408 Asp Leu Glu Ser Glu Arg Thr Gln Arg Ala Thr Glu Arg Trp Leu Gln 375 380 385 tcc caa aca ctg agt atg acg tca gca gag tct cag act tca gaa atg 2456 Ser Gln Thr Leu Ser Met Thr Ser Ala Glu Ser Gln Thr Ser Glu Met 390 395 400 gat ttc tta gag cct gat cct gaa atg cag ttg tta cgg cag cag cta 2504 Asp Phe Leu Glu Pro Asp Pro Glu Met Gln Leu Leu Arg Gln Gln Leu 405 410 415 cgg gat gct gaa gag cag atg cat ggc atg aag aac aag tgt cag gaa 2552 Arg Asp Ala Glu Glu Glu Gln Met His Gly Met Lys Asn Lys Cys Gln Glu 420 425 430 435 ttg tgt tgt gag ttg gaa gag cta cag cat cat cgc cag gtc agt gag 2600 Leu Cys Cys Glu Leu Glu Glu Leu Gln His His Arg Gln Val Ser Glu 440 445 450 gag gag cag agg cgg ctg cag agg gagct tgt gct cag aat gag 2648 Glu Glu Gln Arg Arg Leu Gln Arg Glu Leu Lys Cys Ala Gln Asn Glu 455 460 465 gtg ctt cgg ttt cag acc tcc cac agt gtc acc cag aat gag gag ctg 2696 Val Leu Arg Phe Gln Thr His Ser Val Thr Gln Asn Glu Glu Leu 470 475 480 aag tcc aga ctc tgt acc ctg cag aaa aaa tat gat act agc cag gat 2744 Lys Ser Arg Leu Cys Thr Leu Gln Lys Lys Tyr Asp Thr Ser Gln Asp 485 490 495 gag cag aac gag ctc ttg aag atg cag ctg caa ctt cag act gag ctc 2792 Glu Gln Asn Glu Leu Leu Lys Met Gln Leu Gln Leu Gln Thr Glu Leu 500 505 510 515 cgg cag ctc aaa gtc atg aaa tcc aca ctt g agt gag 2840 Arg Gln Leu Lys Val Met Lys Ser Thr Leu Val Glu Asn Gln Ser Glu 520 525 530 aag gag tta ctg tgc cgg ctg cag aag ctg cac ctc cag cac cag aac 2888 Lys Glu Leu Leu Cys Arg Leu Gln Lys Le Leu Gln His Gln Asn 535 540 545 gtc aca tgt gag aag gaa aag ctg ctg gaa cgg cag cag cag ctg cag 2936 Val Thr Cys Glu Lys Glu Lys Leu Leu Glu Arg Gln Gln Gln Leu Gln 550 555 560 gag ggg ggcg gag gca gag ctg cag cac ctc agg gat acg 2984 Glu Glu Leu Gln Cys His Glu Ala Glu Leu Gln His Leu Arg Asp Thr 565 570 575 gtg gcc tcc ttc aaa gag agc aat gag aag gac aca gag acg cac Gct 3032 Val Phe Lys Glu Ser Asn Glu Lys Asp Thr Glu Thr His Ala 580 585 590 595 cag ctt cag gag atg aag cag ctg tac cag gcc agc aag gac gag ctg 3080 Gln Leu Gln Glu Met Lys Gln Leu Tyr Gln Ala Ser Lys Asp Glu Leu 600 605 610 gag cgg cag aag cac atg tat gac cag ctg gag cag gac ctc ctg ctc 3128 Glu Arg Gln Lys His Met Tyr Asp Gln Leu Glu Gln Asp Leu Leu Leu 615 620 625 625 tgc cag ag ctg gag ctg gag ag gcc tcc cac ccc att ccg gag 3176 Cys Gln Leu Glu Leu Lys Glu Leu Lys Ala Ser His Pro Ile Pro Glu 630 635 640 gac aaa gga aag tgt gct aat aag tgt gac aca ctg ctg tcc aga ctg 3224 Asp Lys Gly Lys Cys Asn Lys Cys Asp Thr Leu Leu Ser Arg Leu 645 650 655 aca gaa ttg cag gaa aag tac aag gcc agc cag aag gag atg ggg cag 3272 Thr Glu Leu Gln Glu Lys Tyr Lys Ala Ser Gln Lys Glu Met Gly Gln 670 665 ctg cag atg gag cag tgt gag ctc ctg gag gat cag agg agg atg cag 3320 Leu Gln Met Glu Gln Cys Glu Leu Leu Glu Asp Gln Arg Arg Met Gln 680 685 690 gag gag cag ggc cag ctg cag gag gag gag ctg cca 3368 Glu Glu Gln Gly Gln Leu Gln Glu Glu Leu His Arg Leu Thr Leu Pro 695 700 705 ctg cca aag agt ggc ctc tta ctc aag agt cag gag cta ctc acc aag 3416 Leu Pro Lys Ser Gly Leu Leu Leu Lys S er Gln Glu Leu Leu Thr Lys 710 715 720 tta gaa gac ctg tgt gag ctg cag ctg ctc tac caa ggc atg cag gag 3464 Leu Glu Asp Leu Cys Glu Leu Gln Leu Leu Tyr Gln Gly Met Gln Glu 725 730 ag ag ag ctg ata cag aac caa gac tgt gta cata 3512 Glu Gln Lys Lys Leu Ile Gln Asn Gln Asp Cys Val Leu Lys Glu Gln 740 745 750 755 tta gag atc cac gaa gag ctg cga cgt ttc aaa gag tct cat Leu Glu Ile His Glu Glu Leu Arg Arg Phe Lys Glu Ser His Phe Gln 760 765 770 gaa gtg ttg gag aat ccc gat gat tcc aaa ttg gct aag tcc tcc aaa 3608 Glu Val Leu Glu Asn Pro Asp Asp Ser Lys Leu Ala Lys Ser Ser Lys 775 780 785 tgt aat cga aac aag caa tcc aag ctg ctc atg gag cag atg cag gcc 3656 Cys Asn Arg Asn Lys Gln Ser Lys Leu Leu Met Glu Gln Met Gln Ala 790 795 800 ctg cag gtg atg gt gg gcc gcg aag cag gag ctc ttg cag 3704 Leu Gln Val Met Tyr Asp Ala Gly Gln Ala Lys Gln Glu Leu Leu Gln 805 810 815 caa gag caa ggg agg ctc cta gag gag cgg aag agg ctg cag gca gac 3752 Gln Glu Gln g Leu Leu Glu Glu Arg Lys Arg Leu Gln Ala Asp 820 825 830 835 ttg cag ctc tgc ctg gaa gaa atg cag ctg ctt caa gtc cag tcc cct 3800 Leu Gln Leu Cys Leu Glu Glu Met Gln Leu Leu Gln G 845 850 tct ata aaa atg agc ctt gag tcc tac ggg aag agc tat ggt agc atg 3848 Ser Ile Lys Met Ser Leu Glu Ser Tyr Gly Lys Ser Tyr Gly Ser Met 855 860 865 gtc ccc agc aat gag aac tgt cgc aag act acc act gtg gat 3896 Val Pro Ser Asn Glu Asn Cys Arg Lys Thr Tyr Asp Thr Thr Val Asp 870 875 880 gac aat gag agc tat tac aag agt tac acc agc acc cag acc agc agc 3944 Asp Asn Glu Ser Tyr Tyr Lys Ser Tyr Thr Ser Thr Gln Thr Ser Ser 885 890 895 aag agc ttt ctc aag agc tat gac agc agc acc agt gcc agt gag gcc 3992 Lys Ser Phe Leu Lys Ser Tyr Asp Ser Ser Thr Ser Ala Ser Glu Ala 900 905 910 915 tat ggg aag agt tac tgc act acc agc aac agc agc att acc tat aag 4040 Tyr Gly Lys Ser Tyr Cys Thr Thr Ser Asn Ser Ser Ile Thr Tyr Lys 920 925 930 aag agt tac ggc agc acc agt agc tct gac acc tgc cag aag agt ttt 4088 Lys Ser Tyr Gly Ser Thr Ser Ser Ser Asp Thr Cys Gln Lys Ser Phe 935 940 945 gtc agc agc tgc act gac gag gaa cct gct gag cct gaa gac atg gag 4136 Val Ser Ser Cys Thr Asp Glu Glu Pro Ala Glu Pro Glu Asp Met Glu 950 955 960 cgc ttt gag gaa atg gtt gtg aaa gtg ctg atc aag ctg cag gcg gtg 4184 Arg Phe Glu Glu Met Val Val Lys Val Leu Ile Lys Leu Gln Ala Val 965 970 975 cag gcc atg ag cag gag gaa cac agc cag ctg caa gag 4232 Gln Ala Met Tyr Gln Ile Ser Gln Glu Glu His Ser Gln Leu Gln Glu 980 985 990 995 cag atg gaa aag tta ctg gcc aag cag aaa gac ctg aag gaa gag Gt Glug 280 Leu Leu Ala Lys Gln Lys Asp Leu Lys Glu Glu Leu 1000 1005 1010 gat gcc tgt gaa agg gag ttc aag gag tgc atg gaa tgc ctt gaa aag 4328 Asp Ala Cys Glu Arg Glu Phe Lys Glu Cys Met Glu Cys Leu 1025 ccc atg gcc ccc cag aac gac aag aat gag atc aaa gaa ctg cag acc 4376 Pro Met Ala Pro Gln Asn Asp Lys Asn Glu Ile Lys Glu Leu Gln Thr 1030 1035 1040 aag ctg cgg gag ctg cag ctg caa tac cag gct agc atg gat gag cag 4424 Lys Leu Arg Glu Leu Gln Leu Gln Tyr Gln Ala Ser Met Asp Glu Gln 1045 1050 1055 ggg cgg ctt ctg gta gtg cag gag cag ctg gag ggg cag ctg cag tgc 4472 Gly Val Gln Glu Gln Leu Glu Gly Gln Leu Gln Cys 1060 1065 1070 1075 tgc cag gag gag ctc cgc cag ctc agg gag aag agg cct tct gtt gtc 4520 Cys Gln Glu Glu Leu Arg Gln Leu Arg Glu Lys Arg Pro Ser Val 1080 10 aaa gaa gcc cgg ggg aag aat gct aat aag aac atg aac aag aat gcc 4568 Lys Glu Ala Arg Gly Lys Asn Ala Asn Lys Asn Met Asn Lys Asn Ala 1095 1100 1105 aat ggg gtt aaa atg aaa aag gtg acc aag ccatg act tct 4616 Asn Gly Val Lys Met Lys Lys Val Thr Lys Pro Cys Ser Asp Thr Ser 1110 1115 1120 gag agc gac ctt gag acc aga aag aag atc agg agg aaa atg aag agg 4664 Glu Ser Asp Leu Glu Thr Arg Lys Lys Ile Arg Arg Lys Met Lys Arg 1125 1130 1135 aca aag agg aag agg aga agg aag aag aca gtg aag agg agg agg atg 4712 Thr Lys Arg Lys Arg Arg Arg Lys Lys Thr Val Lys Arg Arg Arg Met 1140 1145 1150 1155 acg ccg act ctt ccc ttg aaa gtc ccg aag aaa ata acc ccc tca gac 4760 Thr Pro Thr Leu Pro Leu Lys Val Pro Lys Lys Ile Thr Pro Ser Asp 1160 1165 1170 ttt ccg aga gca aaa agt cat ccc cta ccc cca atc ccc cca tct tct 4808 Phe Pro Arg Ala Lys Ser His Pro Leu Pro Pro Ile Pro Pro Ser Ser 1175 1180 1185 cct tgc ctc ttg taggcctggt ggtcatctcg gctttgctct ggtgctggtg 4860 Pro Cys Leu Leu 1190 ggctgagacg tcgtcctaat gcagaacatg tttgggttgt ggaagcctat ggtattcttg 4920 gctattgcag ctgtggctct gtatgtgtta cccaacatgc gacagcagga gtcagagttc 4980 tgcctcatgg agtgatggca gaccttggcc agcgcgaggg cagatcccca gtggccacca 5040 ccctcagctt tgggcaggac acactgtgcc agaaccctcc ccatatgttc catgtgtccc 5100 catctcctca gcctcagtca cccaggctga aaaggcttgt ggggagcggc tgacttccat 5160 ctcctgcctt gtgtaagaac ctgagttcct tgtaattaaa tatcaactga att 5213 <210> 53 <211> 5428 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3092) <400> 53 aa agt gac acc att gtt tct tct tcc aag agt gct tta cat tca tca 47 Ser Asp Thr Ile Val Ser Ser Ser Lys Ser Ala Leu His Ser Ser 1 5 10 15 gtg cct aaa agt acc aat gac aga gat gcc aca cct ctg tca aga gca 95 Val Pro Lys Ser Thr Asn Asp Arg Asp Ala Thr Pro Leu Ser Arg Ala 20 25 30 atg gac ttt gaa gga aaa ctg gga tgt gac tct gaa tct aat agc act 143 Met Asp Phe Glu Gly Lys Leu Gly Cys Asp Ser Glu Ser Asn Ser Thr 35 40 45 ttg gaa aat agt tct gat acc gtg tct att cag gat agc agt gaa gaa 191 Leu Glu Asn Ser Ser Asp Thr Val Ser Ile Gln Asp Ser Ser Glu Glu 50 55 60 gat atg att gtt cag aat agc aat gaa agc att tct gaa cag ttc aga 239 Asp Met Ile Val Gln Asn Ser Asn Glu Ser Ile Ser Glu Gln Phe Arg 65 70 75 act cga gaa caa gat gtt gaa gtc ttg gag ccg tta ag tgt 287 Thr Arg Glu Gln Asp Val Glu Val Leu Glu Pro Leu Lys Cys Glu Leu 80 85 90 95 gtt tct ggt gag tcc act gga aac tgt gag gac agg ctg ccg gtc aag 335 Val Ser Gly Glu Ser Thr Gly Asn Cys Glu Asp Arg Leu Pro Val Lys 100 105 110 ggg act gaa gca aat ggt aaa aaa cca agt cag cag aag aaa tta gag 383 Gly Thr Glu Ala Asn Gly Lys Lys Pro Ser Gln Gln Lys Lys Leu Glu 115 120 125 gag aga cca gtt aat aaa tgt agt gat caa ata aag cta aaa aat acc 431 Glu Arg Pro Val Asn Lys Cys Ser Asp Gln Ile Lys Leu Lys Asn Thr 130 135 140 act gac aaa aag aat aat gaa aat cga gag tct gaa aag aaa gga cag 479 Thr Asp Lys Lys Asn Asn Glu Asn Arg Glu Ser Glu Lys Lys Gly Gln 145 150 155 aga aca agt aca ttt caa ata aat gga aaa gat aat aaa ccc aaa ata 527 Arg Thr Ser Thr Phe Gln Ile Asn Gly Lys Asp Asn Lys Pro Lys Ile 160 165 170 175 tat ttg aaa ggt gaa tgc ttg aaa gaa att tct gag agt aga gta gta 575 Tyr Leu Lys Gly Glu Cys Leu Lys Glu Ile Ser Glu Ser Arg Val Val 180 185 190 agt ggt aat gtt gaa cca aag gtt aat aat ata aat aaa ata atc cct 623 Ser Gly Asn Val Glu Pro Lys Val Asn Asn Ile Asn Lys Ile Ile Pro 195 200 205 gag aat gat att aaa tca ttg act gtt aaa gaa tct gct ata agg cca 671 Glu Asn Asp Ile Lys Ser Leu Thr Val Lys Glu Ser Ala Ile Arg Pro 210 215 220 ttc att aat ggt gat gtc atc atg gaa gat ttt aat gaa aga aac agc 719 Phe Ile Asn Gly Asp Val Ile Met Glu Asp Phe Asn Glu Arg Asn Ser 225 230 235 tcc gaa aca aaa tcg cat ttg ctg ag gct gaa ggt aac 767 Ser Glu Thr Lys Ser His Leu Leu Ser Ser Ser Asp Ala Glu Gly Asn 240 245 250 255 tac cga gat agc ctt gag acc ctg cca tca acc aaa gag tct gac agt 815 Tyr Arg Asp Ser Leu Glu Thr Leu Pro Ser Thr Lys Glu Ser Asp Ser 260 265 270 aca cag acg acc aca ccc tca gca tct tgt cca gaa agc aat tca gtt 863 Thr Gln Thr Thr Thr Pro Ser Ala Ser Cys Pro Glu Ser Asn Ser Val 275 280 285 aat cag gta gaa gat atg gaa ata gaa acc tca gaa gtt aag aaa gtt 911 Asn Gln Val Glu Asp Met Glu Ile Glu Thr Ser Glu Val Lys Lys Val 290 295 300 act tca tca cct att act tct gaa gag gaa tct aat ctc agt aat gac Thr Ser Ser Pro Ile Thr Ser Glu Glu Glu Ser Asn Leu Ser Asn Asp 305 310 315 ttt att gat gaa aat ggt ctg ccc atc aac aaa aat gaa aat gtc aat 1007 Phe Ile Asp Glu Asn Gly Leu Pro Ile Asn Lys Asn Glu As n Val Asn 320 325 330 335 gga gaa tct aaa aga aaa acc gtc atc aca gaa gtc acc acg atg acc 1055 Gly Glu Ser Lys Arg Lys Thr Val Ile Thr Glu Val Thr Thr Met Thr 340 345 350 tcc aca gtg gcc aca gaa tca aaa act gtg atc aag gta gaa aaa ggc 1103 Ser Thr Val Ala Thr Glu Ser Lys Thr Val Ile Lys Val Glu Lys Gly 355 360 365 gat aag caa act gtg gtt tct tcc aca gaa aat tgt gca aaa tcc act 1151 Asp Lys Gln Thr Val Val Ser Ser Thr Glu Asn Cys Ala Lys Ser Thr 370 375 380 gtc aca acc acc act aca aca gtg acc aag ctt tcc aca ccc tcc aca 1199 Val Thr Thr Thr Thr Thr Thr Thr Val Thr Lys Leu Ser Thr Pro Ser Thr 385 390 395 ggc ggc agt gtg gac atc atc tct gta aag gag cag agc aaa acc gtg 1247 Gly Gly Ser Val Asp Ile Ile Ser Val Lys Glu Gln Ser Lys Thr Val 400 405 410 415 gtc acc acg aca gtg aca gac tcc ctg acc acc acg gga ggc aca ctg 1295 Val Thr Thr Thr Val Thr Asp Ser Leu Thr Thr Thr Gly Gly Thr Leu 420 425 430 gtt aca tct atg act gtg agc aaa gag tat tcc aca cga gac aaa gtg 1343 Val Thr Ser Met Thr Val Ser Lys Glu Tyr Ser Thr Arg Asp Lys Val 435 440 445 aaa ctg atg aaa ttt tca aga cca aag aag act cgt tca ggt aca gct 1391 Lys Leu Met Lys Phe Ser Arg Pro Lys Lys Thr Arg Ser Gly Thr Ala 450 455 460 ctg cca tcc tat aga aaa ttt gtt acc aag agc agc aag aag agc att 1439 Leu Pro Ser Tyr Arg Lys Phe Val Thr Lys Ser Ser Lys Lys Ser Ile 465 470 475 ttt gtt ttg cct aat gat gac tta aaa aag ttg gcc cga aaa gga gga 487 Phe Val Leu Pro Asn Asp Asp Leu Lys Lys Leu Ala Arg Lys Gly Gly 480 485 490 495 atc cga gag gtc cct tat ttt aat tac aat gca aaa cct gct ttg gat 1535 Ile Arg Glu Val Pro Tyr Phe Asn Tyr Asn Ala Lys Ala Leu Asp 500 505 510 ata tgg cca tat cct tct cct aga ccg acc ttt ggc atc act tgg agg 1583 Ile Trp Pro Tyr Pro Ser Pro Arg Pro Thr Phe Gly Ile Thr Trp Arg 515 520 525 tat aga ctt cag aca gta aag tcc tta gct gga gtg agc ctg atg tta 1631 Tyr Arg Leu Gln Thr Val Lys Ser Leu Ala Gly Val Ser Leu Met Leu 530 535 540 cgg tta ctg tgg gca agt ttg aga tgg gat gat atg gcg gcc aag gct 1679 Arg Leu Leu Trp Ala Ser Leu Arg Trp Asp Asp Met Ala Ala Lys Ala 545 550 555 cct cca gga gga ggg act aca cgg aca gaa aca tcc gaa act gaa atc 1727 Pro Pro Gly Gly Gly Thr Thr Arg Thr Glu Thr Ser Glu Thr Glu Ile 560 565 570 575 aca aca aca gaa ata att aag agg aga gat gtt ggt cct tat ggc att 1775 Thr Thr Thr Glu Ile Ile Lys Arg Arg Asp Val Gly Pro Tyr Gly Ile 580 585 590 cga tct gaa tat tgt atc agg aaa atc attgt ccc att gga gtt cca 1823 Arg Ser Glu Tyr Cys Ile Arg Lys Ile Ile Cys Pro Ile Gly Val Pro 595 600 605 gaa aca cca aaa gaa acg cct aca cct cag agg aaa ggc ctt cga tca 1871 Glu Thr Pro Lys Glu Thr Pro Thr Pro Gln Arg Lys Gly Leu Arg Ser 610 615 620 agt gca ctg cgg cca aag aga cca gaa acg ccc aag caa act ggc cct 1919 Ser Ala Leu Arg Pro Lys Arg Pro Glu Thr Pro Lys Gln Thr Gly Pro 625 630 635 gtt att att gaa acc tgg gta gca gaa gaa gaa ctg gaa ttg tgg gag 1967 Val Ile Ile Glu Thr Trp Val Ala Glu Glu Glu Leu Glu Leu Trp Glu 640 645 650 655 atc agg gca ttt gct gag aga gta gag aaa gaa ag ca gtt 2015 Ile Arg Ala Phe Ala Glu Arg Val Glu Lys Glu Lys Ala Gln Ala Val 660 665 670 gag caa cag gct aag aaa cga ctg gag cag cag aag ccg aca gtg att 2063 Glu Gln Gln Ala Lys Lys Arg Leu Glu Gln Lys Pro Thr Val Ile 675 680 685 gca act tcc act act tcc cca aca agc agt aca acc agc acc atc tct 2111 Ala Thr Ser Thr Thr Ser Pro Thr Ser Ser Thr Thr Ser Thr Ile Ser 690 695 700 cca gca cag aag gtt atg gtg gcc ccc ata agt ggc tca gtt aca act 2159 Pro Ala Gln Lys Val Met Val Ala Pro Ile Ser Gly Ser Val Thr Thr 705 710 715 gga acc aaa atg gta cta act act aaa gtt gga tct cca gct aca gta 2207 Gly Thr Lys Met Val Leu Thr Thr Lys Val Gly Ser Pro Ala Thr Val 720 725 730 735 aca ttc caa caa aac aag aac ttt cat caa acc ttt gct aca tgg gtt 2255 Thr Phe Gln Gln Asn Lys Asn Phe His Gln Thr Phe Ala Thr Trp Val 740 745 750 aag caa ggc cag tca aat tca ggc gtt gtt caa gta cag cag aaa gtc 2303 Lys Gln Gly Gln Ser Asn Ser Gly Val Val Gln Val Gln Gln Lys Val 755 760 765 ctg ggt atc att cca tca agt aca ggt ac cagt cag caa acc ttt act 2351 Leu Gly Ile Ile Pro Ser Ser Thr Gly Thr Ser Gln Gln Thr Phe Thr 770 775 780 tca ttc cag ccc agg aca gca aca gtc aca att agg ccc aat acc tca 2399 Ser Phe Gln Pro Arg Thr Ala Thr Val Thr Ile Arg Pro Asn Thr Ser 785 790 795 ggc tct gga gga acc aca agc aat tca caa gta atc aca ggg cct cag 2447 Gly Ser Gly Gly Thr Thr Ser Asn Ser Gln Val Ile Thr Gly Pro Gln 800 805 810 815 815 att cgc cct ggt atg acc gtg att aga aca cca ctc caa cag tca aca 2495 Ile Arg Pro Gly Met Thr Val Ile Arg Thr Pro Leu Gln Gln Ser Thr 820 825 830 cta gga aag gca att att cga aca cct gtg atg gta cag cca ggt gct 2543 Leu Gly Lys Ala Ile Ile Arg Thr Pro Val Met Val Gln Pro Gly Ala 835 840 845 cct cag caa gtg atg act caa atc atc agg ggg cag cct gtc tcc act 2591 Pro Gln Gln Val Met Thr Gln Ile Ile Arg Gly Gln Pro Val Ser Thr 850 855 860 gca gtc tcc gcc cct aac acg gtt tcc tca aca cct ggg cag aaa agc 2639 Ala Val Ser Ala Pro Asn Thr Val Ser Ser Thr Pro Gly Gln Lys Ser 865 870 875 tta act tca gca acg tcc act tca aat ata cag tct tca gcc tca caa 2687 Leu Thr Ser Ala Thr Ser Thr Ser Asn Ile Gln Ser Ser Ala Ser Gln 880 885 890 895 ccc cct cgc ccc caa caa gga caa gtg aag ctc acc atg gct caa ctt 2735 Pro Pro Arg Pro Gln Gln Gly Gln Val Lys Leu Thr Met Ala Gln Leu 900 905 910 act cag tta aca cag ggc cac ggt ggc aat caa ggt ttg aca gta gta 2783 Thr Gln Leu Thr Gln Gly His Gly Gly Asn Gln Gly Leu Thr Val Val 915 920 925 att caa gga caa ggt caa act act gga cag ttg cag ttg ata cct caa 2831 Ile Gln Gly Gln Gly Gln Thr Thr Gly Gln Leu Gln Leu Ile Pro Gln 930 935 940 ggg gtg act gta ctc cca ggc ccaggc ca cag cta atg caa gct gca 2879 Gly Val Thr Val Leu Pro Gly Pro Gly Gln Gln Leu Met Gln Ala Ala 945 950 955 atg cca aat ggt act gtt cag cga ttc ctc ttt acc cca ttg gca aca 2927 Met Pro Asn Gly Thr Val Gln Arg Phe Leu Phe Thr Pro Leu Ala Thr 960 965 970 975 aca gcc acc aca gcc agc acc acc acc acc act gtt tcc acg aca gca 2975 Thr Ala Thr Thr Ala Ser Ser Thr Thr Thr Thr Thr Val Ser Thr Thr Ala 980 985 990 gca ggt aga gct gtg ggt tta tcg gaa atg tcg gat gtt act act aca 3023 Ala Gly Arg Ala Val Gly Leu Ser Glu Met Ser Asp Val Thr Thr Thr 995 1000 1005 cgt ggc tgg gct aac aga ggc caa cag gag aac cag tat tta cct ttg 3071 Arg Gly Trp Ala Asn Arg Gly Gln Gln Glu Asn Gln Tyr Leu Pro Leu 1010 1015 1020 gaa gga tat gcc tca agc cag tgagctcaac agttgacata gtcagcctca 3122 Glu Gly Tyr Ala Ser Ser Gactctcg acctgcctcctgcc ctcctattaa aaaagagaga gagagaaagg gggcagaaat aatggttatc ttggtaacta 3242 tgcccacact tactccttgc taagccttgt aggtgctgat tcagtcatgg aggtgatctc 3302 agggagggtg ggtaaatcca gttcatgacc tgagattgag agtgggtcca gaaccacttt 3362 gttgaccttc tgctgcaagt cattgtaact aactaccacc acatcatggg agaaaagtga 3422 agcgtggcaa ttagcctggg ccagatgacc cagctgattt ccagaggctg caacttactt 3482 tggaaaccag ccctctagag ttaggagagt gtacagggga cagccaagag tgtacagggc 3542 ccaggcttcc cagtttcaga gcgtcctgcc ctaagcgtgt ccaaatggag catttcaaag 3602 gcatagacct tctgtaccaa aataca aaat tctcaacttt atttacttta tttatttttt 3662 cgagacaggg tcttgctctg tcgcccaggc tgaagcgaag tagcaccatt actgcttact 3722 gcagccttga actcctggac gcaagcaatc ctcccacctc agcctcccac gtagcttgga 3782 ccatagccat gctccactat gctcagataa ttttttattt tttttgtttt tgtgtagaga 3842 cggggtctca ctatgttgct caaacgatcc tcccacctca acgtcccaag gtgcacaggt 3902 gtgagccacc acgcctggcc agaattctca acttcagaag atttccttca gattcttctt 3962 taaccacagt tttatgttcc agagtaatag aaatggttca tctttccttt ttacaggtac 4022 aggtgaacaa aggcagagta aactgtcacc ccagatgcag gtacatcaag acaaaaccct 4082 gccaccagct cagtcatcaa gtgtgggtcc agcagaagcc cagccacaga ctgctcagcc 4142 ttcagctcag ccccagcccc aaacccagcc ccagtcccca gctcagcctg aagttcagac 4202 tcagcctgaa gttcagaccc aaacaactgt ttcatcccat gtcccttctg aagcacaaca 4262 cacacacaca cacacgcctc atgtaatgga cttttataac aaaagaaaaa atttggattt 4322 ctaatttaca aatggcaaat tatttatccc tctctggatg caccaaagac cagtaaagtt 4382 tatagctttt ccatctatat ttataaagca atactgtatt ataaaaatca atatttttat 4442 cacatgcttg aaatttttat tttgttgttt taaaatgtgc actctaaaca tatcagaacc 4502 ttatttcttc ctatgaactt aagctgcctg cgcacaaaaa aaaaaaaaat ttaccaaatg 4562 gagatgcagt agagtccata ggctctaaaa actaaaagaa atgggatgca gggggaacaa 4622 gttatttgtc ctgagttact gtacttgctt gacatggttg ttgggtacta aatcacaaaa 4682 gaatccattc caggtatcca tgtctggggg ttgggctgtg tctagattag aaactgggtt 4742 tcaagctttg catgatggga gagcgtcctc tcctctatca gctgcgtgtg ttctggatag 4802 gacagtagcc cggagatgga aaccaccttc agtaccatta gcccaccata ccaagtaaca 4862 agttaggcag gaatcgtggg aatttattga gtcagctttg agtgtttgag agaatgtaaa 4922 caagattggc tcgaattgta aacgtttgta ctttggatga gttcatggtt ctttaggtca 4982 ccttaatacc agctatcttt ggtagaagct acagcattca gtttctctgg aaactgtatc 5042 acatttttgc attttaaaaa ttttacagta tcaaaaaacc aaaatctgct tatgaaacaa 5102 aacatgaagc aggacatatt tggattctat ttatttaaaa ttaaattctt tgcaaaattg 5162 aacttctcaa ctaaaacgtg tccatgtcag aattttaact gttagcaggt agtttgtggc 5222 aaagatggct aaataatgaa gcaaattaga atctgtgtgt atactaatga gctgcttttt 5282 ttctgttgag actatcatta tttgtcttat taccca agag gcaattacct gaatttggat 5342 gtctgaatta taacttatgc aggaatagtt ctgtaaatac atttaaataa actgtaaaga 5402 tatttaataa atatagtatt tatact 5428 <210> 54 <211> 5779 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2374) <400> 54 g gag ctg ggg atc ccc gct ctc ctg gac ccc aat gac atg gtc tcc atg 49 Glu Leu Gly Ile Pro Ala Leu Leu Asp Pro Asn Asp Met Val Ser Met 15 10 15 agc gtc cct gac tgc ctc agc atc atg acc tat gtg tcc cag tat tac 97 Ser Val Pro Asp Cys Leu Ser Ile Met Thr Tyr Val Ser Gln Tyr Tyr 20 25 30 aac cac ttc tgc agt cct ggc caa gct ggt gtc tcg cca ccc aga aag 145 Asn His Phe Cys Ser Pro Gly Gln Ala Gly Val Ser Pro Pro Arg Lys 35 40 45 ggc ctt gca ccc tgt tcc ccg ccg tct gta gca ccc act cca gtg gaa 193 Gly Leu Ala Pro Cys Ser Pro Pro Ser Val Ala Pro Thr Pro Val Glu 50 55 60 tca gaa gat gtg gct cag ggc gag gag ctc tcc tca ggc agc ctg tca 241 Ser Glu Asp Val Ala Gln Gly Glu Glu Glu Leu Ser Ser Gly Ser Leu Ser 65 70 75 80 gag cag ggc acc ggc cag acc ccc agc agc acg tg gcc tgc cag 289 Glu Gln Gly Thr Gly Gln Thr Pro Ser Ser Thr Cys Ala Ala Cys Gln 85 90 95 cag cat gtg cac ttg gtg cag cgc tac ctg gct gac ggc agg ctg tac 337 Gln His Val His Leu Val Gln Arg Tyr Leu Ala Asp Gly Arg Leu Tyr 100 105 1 10 cat cgc cac tgc ttc cgg tgt cgg cgg tgc tcc agc acc ctg ctc cct 385 His Arg His Cys Phe Arg Cys Arg Arg Cys Ser Ser Thr Leu Leu Pro 115 120 125 ggg gct tat gag aat ggg cct gag gag ggc acc ttt gtg tgt gca gaa 433 Gly Ala Tyr Glu Asn Gly Pro Glu Glu Gly Thr Phe Val Cys Ala Glu 130 135 140 cac tgt gcc agg ctg ggc ccg ggg aca cgg tcg ggg acc agg cct ggg 481 His Cys Ala Arg Leu Gly Pro Gly Thr Arg Ser Gly Thr Arg Pro Gly 145 150 155 160 ccc ttc tca cag cca aag cag cag cac cag cag caa ctc gca gaa gat 529 Pro Phe Ser Gln Pro Lys Gln Gln His Gln Gln Gln Leu Ala Glu Asp 165 170 175 gcc aag gat gtt cca gga ggc ggc ccc agc tcc agt gct cct gca ggg 577 Ala Lys Asp Val Pro Gly Gly Gly Pro Ser Ser Ser Ala Pro Ala Gly 180 185 190 gct gag gcc gat gga ccc aag gcc agc cct gag gcc cgg ccg cag atc 625 Ala Glu Ala Asp Gly Pro Lys Ala Ser Pro Glu Ala Arg Pro Gln Ile 195 200 205 cct acc aag ccc cgg gtt cct ggc aaa cta cag gag ctg gcc agc ccc 673 Pro Thr Lys Pro Arg Val Pro Gly Lys Leu Gln Glu Leu Ala Ser P ro 210 215 220 cct gcg ggc cgc ccc acc cct gcc ccc agg aag gcc tct gag agc acc 721 Pro Ala Gly Arg Pro Thr Pro Ala Pro Arg Lys Ala Ser Glu Ser Thr 225 230 235 240 acc cca gca ccc ccc acg ccc cgg ccc cgc tcc agt ctg cag cag gag 769 Thr Pro Ala Pro Pro Thr Pro Arg Pro Arg Ser Ser Leu Gln Gln Glu 245 250 255 aac ctg gtg gag cag gct ggc agc agc agc ctg gtg aac ggg aga ctg 817 Asn Leu Val Glu Gln Gly Ser Ser Ser Leu Val Asn Gly Arg Leu 260 265 270 cac gaa ctg cct gtc ccc aag ccg agg ggg aca ccg aag ccg tcc gag 865 His Glu Leu Pro Val Pro Lys Pro Arg Gly Thr Pro Lys Pro Ser Glu 275 280 285 ggg aca cca gcc ccc agg aag gac ccc cca tgg atc acg ctg gtg cag 913 Gly Thr Pro Ala Pro Arg Lys Asp Pro Pro Trp Ile Thr Leu Val Gln 290 295 300 gca gaa cca aag aag aag cca gcc cca ctt ccc cca agc agcg ccg 961 Ala Glu Pro Lys Lys Lys Pro Ala Pro Leu Pro Pro Ser Ser Ser Pro 305 310 315 320 ggg cca cca agc cag gac agc agg cag gtg gag aat gga ggc acc gag 1009 Gly Pro Pro Ser Gln Asp Ser Arg Gln Val GluAsn Gly Gly Thr Glu 325 330 335 gag gtg gcc cag ccg agc cca acg gcc agc ctg gag tcc aaa ccc tat 1057 Glu Val Ala Gln Pro Ser Pro Thr Ala Ser Leu Glu Ser Lys Pro Tyr 340 345 350 aac ccc ttt gag gag gag gag gag gac aag gag gaa gag gct cca gct 1105 Asn Pro Phe Glu Glu Glu Glu Glu Asp Lys Glu Glu Glu Ala Pro Ala 355 360 365 gca ccc agc ctg gcc acc agc cct gcc ctg ggc cac ccg gag tcc aca 1153 Ala Leu Ala Thr Ser Pro Ala Leu Gly His Pro Glu Ser Thr 370 375 380 ccc aag tcc ctg cac ccc tgg tac ggc atc acc cct acc agc agc ccc 1201 Pro Lys Ser Leu His Pro Trp Tyr Gly Ile Thr Pro Thr Ser Ser Pro 385 390 395 400 aag aca aag aag cgc cct gcc ccg cgc gca ccc agc gcg tcc cca ctg 1249 Lys Thr Lys Lys Arg Pro Ala Pro Arg Ala Pro Ser Ala Ser Pro Leu 405 410 415 gct ctc cac gcc tcc cgc ctc tgg cac ccg ccc tcg gcc aca 1297 Ala Leu His Ala Ser Arg Leu Ser His Ser Glu Pro Pro Ser Ala Thr 420 425 430 cca tcg cca gcg ctc agc gtg gag agc ctg tcg tct gag agc gcc agc 1345 Pro Ser Pro Ala Leu Ser Val Glu Ser Leu Ser Ser Glu Ser Ala Ser 435 440 445 cag act gca ggt gca gag ctt ctg gag ccg cca gct gtg ccc aag agc 1393 Gln Thr Ala Gly Ala Glu Leu Leu Glu Pro Pro Ala Val Pro Lys Ser 450 455 460 tcc tca gag cct gct gtc cat gcc cct ggt acc cct gga aac cct gtc 1441 Ser Ser Glu Pro Ala Val His Ala Pro Gly Thr Pro Gly Asn Pro Val 465 470 475 480 agc ctc tct acc aac tcc tcc ctg gcc tcc tct ggg gaa cta gtg gag 1489 Ser Leu Ser Thr Asn Ser Ser Leu Ala Ser Ser Gly Glu Leu Val Glu 485 490 495 cct aga gtg gaa caa atg cct caa gcc agc cct ggc ctt gcc ccc agg 1537 Pro Arg Val Glu Gln Met Pro Gln Ala Ser Pro Gly Leu Ala Pro Arg 500 505 510 acc agg ggc agc tca ggt ccc cag cca gcc aag ccc tgc agt ggc gcc 1585 Thr Arg Gly Ser Ser Gly Pro Gln Pro Ala Lys Pro Cys Ser Gly Ala 515 520 525 acc cca acg cct ctc ttg ttg gtt gga gac agg agc ccg gtg cct tcc 1633 Thr Pro Thr Pro Leu Leu Leu Val Gly Asp Arg Ser Pro Val Pro Ser 530 535 540 cct gga agc tcg tcc cca cag ctg cag gta aag tcc tcc tgc aag gag 1681 Pro G ly Ser Ser Ser Pro Gln Leu Gln Val Lys Ser Ser Cys Lys Glu 545 550 555 560 aat cct ttt aac cgg aag cca tca cct gca gcg tcc cca gcc aca aag 1729 Asn Pro Phe Asn Arg Lys Pro Ser Pro Ala Ala Ser Pro Ala Thr Lys 565 570 575 aag gcc acc aag gga tcc aag cca gtg agg cca cct gcc cct gga cac 1777 Lys Ala Thr Lys Gly Ser Lys Pro Val Arg Pro Pro Ala Pro Gly His 580 585 590 ggc ttt cca ctc atc aaa cgc aag gtc cag gct gac cag tac atc cct 1825 Gly Phe Pro Leu Ile Lys Arg Lys Val Gln Ala Asp Gln Tyr Ile Pro 595 600 605 gag gag gac atc cat gga gag atg gat acc att gag cgc cgg ctg gat 1873 Glu Glu Asp Ile His Gly Glu Met Asp Thr Ile Glu Arg Arg Leu Asp 610 615 620 gcc ctg gag cac cgt ggg gtg ctg ctg gag gag aag ctg cgt ggc ggc 1921 Ala Leu Glu His Arg Gly Val Leu Leu Glu Glu Lys Leu Arg 630 ctg aat gag ggc cgt gag gat gac atg ctg gtg gac tgg ttc aag ctc 1969 Leu Asn Glu Gly Arg Glu Asp Asp Met Leu Val Asp Trp Phe Lys Leu 645 650 650 655 atc cac gag aag cac cta ctg gg cgg ctc atc tat 2017 Ile His Glu Lys His Leu Leu Val Arg Arg Glu Ser Glu Leu Ile Tyr 660 665 670 gtc ttc aag cag cag aac ctg gag cag cgc cag gct gat gtc gag tat 2065 Val Phe Lys Gln Gln Asn Leu Glu Gln Ala Asp Val Glu Tyr 675 680 685 gag ctc cgg tgc ctc ctc aat aag cca gaa aag gac tgg acg gag gag 2113 Glu Leu Arg Cys Leu Leu Asn Lys Pro Glu Lys Asp Trp Thr Glu Glu 690 695 700gg acgg gcc aag gtg ctg atg cag gag ctt gtg acc ctc att 2161 Asp Arg Ala Arg Glu Lys Val Leu Met Gln Glu Leu Val Thr Leu Ile 705 710 715 720 gag cag cgc aac gct atc atc aac tgc ctg gat gag gac cgg cag agg agg Gln Arg Asn Ala Ile Ile Asn Cys Leu Asp Glu Asp Arg Gln Arg 725 730 735 gag gaa gag gaa gac aag atg ttg gaa gcc atg atc aag aag aaa gag 2257 Glu Glu Glu Glu Asp Lys Met Leu Glu Ala Lys Glu 740 745 750 ttc cag agg gag gct gaa cct gag ggc aag aag aag ggg aag ttc aag 2305 Phe Gln Arg Glu Ala Glu Pro Glu Gly Lys Lys Lys Gly Lys Phe Lys 755 760 765 acc atg aag atg ttg aaact gga aac aaa cgt gat gcc aag agc 2353 Thr Met Lys Met Leu Lys Leu Leu Gly Asn Lys Arg Asp Ala Lys Ser 770 775 780 aag tcc ccc aga gac aag agc taacagcacg agaagccagt tggggactgc 2404 Lys Serc arg 790 gggctgtgct ctgtttgaag ggggcgccct gctcccctca 2464 gatcagtcag gaggaagatg actaagggga gggatcctct gggtgatggc ctcttcctcc 2524 tcagggacct ctgactgctc tgggccaaag aatctcttgt ttcttctccg agccccaggc 2584 agcggtgatt cagccctgcc caacctgatt ctgatgactg cggatgctgt gacggaccca 2644 aggggcaaat agggtcccag ggtccaggga ggggcgcctg ctgagcactt ccgcccctca 2704 ccctgcccag cccctgccat gagctctggg ctgggtctcc gcctccaggg ttctgctctt 2764 ccaggcaggc cagcaagtgg cgctgggcca cactggcttc ttcctgcccc atccctggct 2824 ctgagtctct gtcttcctgt cctgtgcagg cgcccttgga tctcagtttc cctcactcag 2884 gaactctgtt tctgaagtct tcagttaagt ttgagtttat gactgagtgg cctgtactgt 2944 cagacgtgaa tgggcctgac gggcaaatcc atccctctct ccctcacagt tccaggccc gcctccctccctgcctccctgcc catgctg gggcaggtga gtgctctgtt agctgctccc agtgctgtcc ccaggctgca 3124 gttctggtcc ctggttgtca ggtaggaagg gtgcacttga agcaggtgct catctcggtt 3184 ccttaacgtt tatagtctga cccctcactt aggctttcct ctgccacccc ggtccaggga 3244 agaggctcgc tcccgcccat ggtcatcact ggtctgtctg ctctgttgtc tgttctttcc 3304 ctgactccct cccaccgaag gcctgatggc tactcacccc tctgggatgg ctatgggaga 3364 ggaggagtga tggggaccgc caccttttct gcaggaaatg tgcccagcag ctcttggtca 3424 aagcactgtt gctataagct atctctggga tgcctctagg cccccttccc tctacacacc 3484 tctgggaaaa gattacactg tattaactct cgaggagttt cctcaccaat aaacagacaa 3544 cctcaactgc cagtgccctg cagcctcggg ccacagcggc agccttgttt gccttcccac 3604 ctgcctctgc cacacctggt ggctgaacat ctctggtcgc ccagaggcca tgttggggcc 3664 atcctccaag agggatctct gccctcaccg cctgccactg ggcaggatcc ctttcctctg 3724 cagggagagg tggctcctcg gccatgcagc ccctggcagg ctccttctaa acatgcctgt 3784 tgacctggag ctggcgccac caactccagg gcctttccag ggccagacag gtaacacgca 3844 tgaacccgag tgacagctct gacgggctgt ttcggtgtca ggagacaaag ctggcagggg 3904 caggggtg aa ctggaggcaa gtcaagtcac ctgtggcctg tggggctgaa tgtgggcccg 3964 gtgttgccag atcctttgtc ataagaagct agaaatccag attttatgtg tgtgtaattt 4024 gtaaatgctg aaagctagcc tgaatttttt tttttttttt gagacagagt ctcgctctgt 4084 cgcccaggct ggagtgcagt ggcgcgatct cagctcactg caggctccgc ctcctgggtt 4144 cacgccatcc tcctgcctcg gcctcctgag cagctgggac tacaggcgca tgctacgacg 4204 cctggctaat tttttgtatt tttagtagag acggggtttc accgtgttaa ccaggatggt 4264 ctcgatctcc tgaccttgtg atccacccac cttggcctcc caaagtgctg ggattacagg 4324 cgtgagccac cacgcccggc cactagcctg aatttcaatc aagggttggc tgatactgtg 4384 tgtccagggt ggactggatt tgtcctgggg ggttctctgg tttgctgcct cctgaccaca 4444 tgatggggcc ttcgaggtcg aggacaactg ttcccattag attgcaccct ctgccctcag 4504 gttcttgagg gtgtgtggac acagaggctt tccatgggat gtccctgagc cggcccttga 4564 ttggggcctc accatttaca gggccgtttt attctgcaaa ccgaaacttg ggtcatgtga 4624 cctgatggga ttatgggact ccctccaggt gcccgagaca aggttgatat ttccaaaata 4684 ttttggtgat ttagtgggac aagcaaatga cagaataccg gagaaggcag ggatcgtggg 4744 tgtcaggagc cag aggggag ggggacagat gtgctgtgta caggacaagg tgtcaggtga 4804 ctccttccca gcagggcctc gcagatgcac aagcacggag ctggtgggtt ttgcccaaga 4864 aaggtcacgc ggcacatgca gggattggaa ctcccaggcc agggctctag gtcgctccca 4924 ccttttcatg tttctttctg tggccatggg tatagtggaa agacataaag ctaaagccaa 4984 cttttaatcc tgaatgcact gcttgccagg taaatgccct tggttgtggt atcttgttga 5044 gacttagttt tcacagaggg ataatgaacc gttgcagagg tttattgaga tcattaacag 5104 agtggaattc agcacctgcc actgcactcc agcctgggcg acagagcaag actcagtctc 5164 aaaaaaaaaa aaaattagct gggcagggca tggtgatggt gcctgtaatc ctagctactt 5224 gggaggctga ggcatgagaa ttgcctgaac ccaggaggtg gaggttgcag tgagccgaga 5284 tcgtgccact gtactccagc ctgggtgaca gcgcgagact ccgtctcaaa aaaagctggg 5344 tgtggggaac acctgtggtc ccagctattc tggagactga ggcaggagga ttgcttgagc 5404 tcaggagttc tggctgcagt gagctatgat catgccactg tattacagaa tgggtgacag 5464 aatgagagcg acactgtctc aaaaaaaaaa aaaaaaaaag gccgggagcg gtcgtttgtg 5524 cctgtaatcc caacactttg ggaggccagg gtgggcggat cacttgaggc caggagttca 5584 agaccagcct ggccaaca tg gtgaatcccc atctctacta aaaaaattaa ctggacatgg 5644 tggtggacac ttgtaatccc agctactcag gaggctgaca catgagaatt gcttgaaccc 5704 gggaggcgga ggttacagtg agccgagata gcaccactgc actccaacct gggcagct 57 <210> 55 <211> 5482 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1421) <400> 55 aa gac act gaa cct cca gtg cag aca gcc gtc ctg aca gct tca gcc 47 Asp Thr Glu Pro Pro Val Gln Thr Ala Val Leu Thr Ala Ser Ala 1 5 10 15 cca gca gct cag gcc gga gca tct cag ggg cta cac gct ttg ctg gag 95 Pro Ala Ala Gln Ala Gly Ala Ser Gln Gly Leu His Ala Leu Leu Glu 20 25 30 gaa cgg att cac aac tac cga gag gct gcg gcc agt gcc aag gag gca 143 Glu Arg Ile His Asn Tyr Arg Glu Ala Ala Ala Ser Ala Lys Glu Ala 35 40 45 ggc gaa gca gcc aaa gcc agg cgc tgc gag cgc ggc ctg aag acc ttg 191 Gly Glu Ala Ala Lys Ala Arg Arg Cys Glu Arg Gly Leu Lys Thr Lec 50 55 gag cag cta gcc tct gtg agg aga ggc aga aag atc aat gag gat 239 Glu Ser Gln Leu Ala Ser Val Arg Arg Gly Arg Lys Ile Asn Glu Asp 65 70 75 gag atc cca cct cca gtg gcc tta gga aag cgg ccc ctg gcc ccc 287 Glu Ile Pro Pro Pro Val Ala Leu Gly Lys Arg Pro Leu Ala Pro Gln 80 85 90 95 gaa cca gcc aac agg agc cct gag aca gac cct cca gct ccc cct gcc 335 Glu Pro Ala Asn Arg Ser Pro Glu Thr Asp Pro Pro Ala Pro Pro Ala 100 105 110 ttg gag tca gac aac ccc tcc caa cct gag acc agc ctc cct ggc att 383 Leu Glu Ser Asp Asn Pro Ser Gln Pro Glu Thr Ser Leu Pro Gly Ile 115 120 125 tct gcc cag ccc gtt tca gac tta gac cca gac ccg cgg gcc ctg ctg 431 Ser Ala Gln Pro Val Ser Asp Leu Asp Pro Asp Pro Arg Ala Leu Leu 130 135 140 tca tcc cga cag aga gag tac aaa gtg gct gcc ctc agt gcc aag cgg 479 Ser Ser Arg Gln Arg Glu Tyr Lys Val Ala Ala Leu Ser Ala Lys Arg 145 150 155 gct gga gag cta gac cgt gcc cga gag ctc atg agg att ggg aag aga 527 Ala Gly Glu Leu Asp Arg Ala Arg Glu Leu Met Arg Ile Gly Lys Arg 160 165 170 175 tt ttc ggt gct gtc gt gcc ctg gag aag ggg cag ccc gtg gat ctg 575 Phe Gly Ala Val Leu Glu Ala Leu Glu Lys Gly Gln Pro Val Asp Leu 180 185 190 agt gcc atg ccc ccg gca cct gag gat ctg aag ccc cag cag gct tct 623 Ser Ala Pro Pro Ala Pro Glu Asp Leu Lys Pro Gln Gln Ala Ser 195 200 205 cag gct ccc aca gca ccc tca gtc att ccc cca gcc gtg gag cga gtg 671 Gln Ala Pro Throra Ala Pro Ser Val Ile Pro Pro Ala Val Glu Arg Val 210215 220 cag cca gtg atg gcc cct gac gtc cca gca acc cca gtg gcc cct aca 719 Gln Pro Val Met Ala Pro Asp Val Pro Ala Thr Pro Val Ala Pro Thr 225 230 235 gag tca cag aca gtg ctg gat gcc ctg cag cag agg ctg aac aag tac 767 Glu Ser Gln Thr Val Leu Asp Ala Leu Gln Gln Arg Leu Asn Lys Tyr 240 245 250 255 cgc gag gcg ggc atc cag gcc cgg agt ggt ggg gac gag cgc aag gct 815 Arg Glu Ala Gly Ile Gln Ala Argin Ser Gly Gly Asp Glu Arg Lys Ala 260 265 270 270 cgg atg cat gag cgc att gcc aag caa tat caa gat gct att cga gca 863 Arg Met His Glu Arg Ile Ala Lys Gln Tyr Gln Asp Ala Ile Arg Ala 275 275 280 285 cac cga gca gga cgg aaa gtc aac ttt gct gaa ttg cct gtt cct cca 911 His Arg Ala Gly Arg Lys Val Asn Phe Ala Glu Leu Pro Val Pro Pro 290 295 300 gga ttt ccc ccc atc cct ggc ctg gag tcc act atg ggt gtt gag g959 Gly Phe Pro Pro Ile Pro Gly Leu Glu Ser Thr Met Gly Val Glu Glu 305 310 315 gac gca gtg gca gcg aca ttg gca gct gca gag aaa ctg gcc tct gca 1007 Asp Ala Val Ala Ala Thr Leu Ala Ala Ala Glu Lys Leu Al a Ser Ala 320 325 330 335 gag gat tca gcc ccg gct gat aaa gac gag gac gag cct cct ggg cac 1055 Glu Asp Ser Ala Pro Ala Asp Lys Asp Glu Asp Glu Pro Pro Gly His 340 345 345 350 ctg cag ggt gag ccc cca gca cag gcc cca gtg gcc aag aaa cct gca 1103 Leu Gln Gly Glu Pro Pro Ala Gln Ala Pro Val Ala Lys Lys Pro Ala 355 360 365 cgg ccc aca gtc cct tca tcc cag cgc ctg cct gag ccc agg gcc tca 1151 Arg Pro Thr Val Pro Ser Ser Gln Arg Leu Pro Glu Pro Arg Ala Ser 370 375 380 agt tct aag gag tca ccg agt cca tct gtg cgg gag cag ctg gca ctg 1199 Ser Ser Lys Glu Ser Pro Ser Pro Ser Val Arg Glu Gln Leu Ala Leu 385 390 395 ctg gag gca cgg aaa ctg cag tat cag cgg gca gcc ctg cag gcc aag 1247 Leu Glu Ala Arg Lys Leu Gln Tyr Gln Arg Ala Ala Leu Gln Ala Lys 400 405 410 415 cgc agc cag gac ctg gag cag gcc aaa g cgg gta gcc aaa 1295 Arg Ser Gln Asp Leu Glu Gln Ala Lys Ala Tyr Leu Arg Val Ala Lys 420 425 430 tgg ctt gag gct cag atc atc cag gcc cga tct ggc aga cct gtt gat 1343 Trp Leu Glu Ala Gln Ile Ile Gln Ala Arg Ser Gly Arg Pro Val Asp 435 440 445 ctg tcc aag gtg agt ccc acc tgg tta acc acc agg act tct cag gcg 1391 Leu Ser Lys Val Ser Pro Thr Trp Leu Thr Thr Arg Thr Ser Gln Ala 450 455 460 gag gtg gcg gct ggc agg ctt gac agg ctg tgaacaaggg cagcttctgg 1441 Glu Val Ala Ala Gly Arg Leu Asp Arg Leu 465 470 gatgaggcag ggtttggaca gagcatgatg acagctggga aagagccttt tgctcatact 1501 cctctacctc acggccccaa aggaaaccag gagaagggaa ggtgggctgc ctgtggtcag 1561 agatgacaag gctgggccag gccatgggag gcaagagtgt tattttggga tagaatggga 1621 ggcgatgagt tgtcatcact ggactttagt agaagctgaa gaattactta gtttgggctc 1681 ctgcctttgt tggacttggt agaggagtaa tctgactctt ggggcccgag gggccttgtg 1741 acctgggtag gtgccttcgc ccttgacgga tgaggagggt gacttcatcc tcatccacca 1801 tgaggacctg cgactctccc agaaggcgga ggaggtgtat gcccagctgc aaaaaatgct 1861 tctggagcaa caagagaagt gcctgctgtt ctccaagcag ttcatgcacc agggcaacgt 1921 ggctgagacc acccgatttg agaagcttgc tcaggaccgc aagaaacagc tggagatcct 1981 gcagctggcc caggctcagg gcctcgaccc tcccacccac cactttgagt tgaagacatt 2041 ccagactgtg aggatcttct cagaactcaa cagcacagaa atgcatctga tcattgtccg 2101 gggaatgaac ctcccagccc ctccaggggt gactcccgat gacctggatg cttttgtgcg 2161 gtttgagttt cactacccta actcggacca ggctcaaaaa agcaaaacag ctgtggtgaa 2221 gaacacaaac tctccagaat ttgatcaact cttcaaacta aacatcaacc gaaaccaccg 2281 gggcttcaag agggtgatcc agagcaaagg catcaagttt gagatcttcc acaaagggtc 2341 cttcttcaga agcgacaagc tggttggcac agcacacctg aaactggagc ggctggagaa 2401 tgagtgtgag atcagagaaa ttgtggaggt cctggatgga aggaagccca ccggggggaa 2461 gctggaggtg aaggtgaggc tgcgggagcc tctgagtggc caggatgtgc agatggtcac 2521 tgagaactgg ctggttctgg agcccagggg cttgtgaggt gggcagctct ctgggccttc 2581 agaacctttg ccccctcctt ttactcaact aactactcaa ctcatatctg gagagaaaac 2641 ctaggagttt ctcatctatg agaaagacct accatgctgg gtagggctta tgggctgagt 2701 ttctgatgtt cctcagtaga actgggaaga gaaggtaacc ttccaaggtt taactatcta 2761 tctatctatc tatcttcagg aaaccctttc taaaatcttt gtgttttcac tgcagtttag 2821 actgacttct tgtgctttgc acccctgtgt agccgatggc cagcaccagg agagga gtca 2881 ggccgcgact gtgcaggaga tgactttccc agctttgctg gcttcagaag cctttgtaca 2941 taagagatgc tgctacccaa gcaccaaaga cctgttaagc atgtgcacta ctgaccacga 3001 ctctggtctt tcctgttgtt ggcccctctg gggctctaca gaaacaggct gggttccagg 3061 agcccatctc cccgctgtct ccccctgccc cgagtctgga agagggcaag gacacttcca 3121 ttcctctgta ccatggagtc ctgcagcccc ttaacccctg cgtggcaact gtgtacagct 3181 tacccctgcc tccagttgca ccacttctag atgtgccttt aaaagatcta actatgggat 3241 gggagaactt gagggtgatc gggaacctcc cctgctgagg gtggtgtcag ggttccgtga 3301 ctccagtggg ccagtggtag cctgtcccag acaactccgt caccccagct ctgcctgtgc 3361 ctttatccct gacagctgct gcactagcct tcctgcttcc ctaaggactt agtggagggg 3421 gaaagttgtt tttggtacta cttggtggga agtaagggga aggttggatc ttgggtttgg 3481 tctacccacc caagagaaaa gactgttaac tggaagaaaa aatatatata taaaatttta 3541 tgtagacacg tttatttatc taggaaacta agtctaactc attgtaggga ttttatactc 3601 aactatacag agtatccacc aaagtcctaa tctaaagtcc tgctccctgt cactttttaa 3661 aagccagggt agcagtaaca tgacaaacgg ctgctgtggc ttcctcttga gagaggacag 3721 ggaaagcctt tcctcttcgg ctggttatgt ggggaacttc cttagttttt ttccacaaga 3781 aattctcctt tggctttgtt tttctgaatg gatggagact atgaaggggt ttgtagttgt 3841 aagagattta atattcaaaa ctgaaatatt ctgcatttct tagaaatacc ccatcttccc 3901 ccaccccctt tttgaattat taattcaaga tcaacaaagc attcctcaag atcactttta 3961 aaaaaggtta gaagtgaagc aaatacattc agcttactga tcactatagt attgcataag 4021 cacagctcaa gaactgagct ttgtatgtgt ccttttgggg gataacaggg ctggaccatg 4081 cttccctgcc cttaaacgca gagcttttag tgggtcacag agcgggaact acacacaagt 4141 gacttttttc cccatgagcc ctctggccga tttttttttt tttttttttt ttgagacaga 4201 gtagctctct gccggccagg ctggagtgca gtggcatgat ctcggctcgc tgcagccccc 4261 gcctcccggg ttcaggcgat tctcctgtgt cagtctcctg ggtagctggg attgcaggcg 4321 cccaccacta tgcccagctg atttttttgt ttttggtgga gacggtgttt caccatgttg 4381 gtcgggctgg tctcgaactc ctgacctcat gatccaccca cctcggcctc ccaaagtgct 4441 gggattacag gtgtgagcca ccgcacccgg ctggccaatc ttatcagaag tgagctacca 4501 aaacttccac agatgtgaga tttaacactt aattgcagtc acgtgtatgc aacacagcaa 4561 taatctagaa tgaaaaggag ggtgattagc cttcataaga tgacctatag agcaaagaaa 4621 ggtgactgga agggttccta acccaaccta ctccccttag ggtgtgtatc caacccagtg 4681 cttcctaaga gggttacgga ccactgtggt tatcctctaa agttccagcc agctctagga 4741 gtttctaaat tcaggcctct gttggaaatg gcctatttcg atagatagaa agttttctat 4801 agctctaaag gtttctcctt tgcaacccat tcaatttcag tctgctgctt tgctctttca 4861 aaacagaacc tccaggctga cgaggcaaga caaagcctcc caccagactt ggagattgaa 4921 gttcttaaaa ggcctttgtt gtagccaaag gcatgcatgc gtcactggta gtaggaggag 4981 cctgtcccag cttcatcttg tcctgagatt tatccacata caggaaacag gcgggacaca 5041 gtggctcacg cctgtaatcc caccactttg gaaggctgag gcaggtggat cacctgaggt 5101 cgggaattcg ggaccagcct ggccggcatg gtgaagcccc gtctccacta aaaacggaaa 5161 caattagctg ggcatggtgg ccggcgcctg tggtcccagc tactagggag gctgagacac 5221 acgaatccct tgagcccggg aagcggaggt tgcagtgagc ctcgattgta ccactgcgct 5281 ccagcctggg cgacagagca agactctgtc tcaaaacaaa cacaaataca gtatccaaac 5341 attggagatt agtgactcac ctgcagttgg gagccagcta caacccaaat cattttaaaa 5401 ttttca attc tttgatctca tgcaatgcac actttcttct gaattagcaa actgaataaa 5461 ctacagaaat tttttagaat c 5482 <210> 56 <211> 5360 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1601) .. (3916) <400> 56 cttccagtct ctgctgatgt gatttcagat gggcgcggct ccagaccatc ccctgcaatg 60 gccagttacg cagcctctcc gagccactgc ctctctgtgg aaggagggcc tgaggctgac 120 ggggagcagc cgcctcgctt ggccactctg ggacctgggg tgatggaggg tgcagcggag 180 actgaccagg aggctctgtg tgcaggggag actggggccc agaagccacc tggagatcgg 240 atgctgtgtc cagggaggat ggatggtgca gctctggggg aacagccaac tgggcagaag 300 ggagcctcgg caagggggtt ctggggacca agagagacca aggcgttggg tgtgtgcaaa 360 gagtctggga gcgagcctgc ggaggacagc agcagggccc acagccgatc agaggaaggt 420 gtctgggagg agaacacgcc ccccttgggc cccctgggtt ttcccgagac ttccagctct 480 ccggcggaca gcaccaccag cagctgcctc cagggcctcc cggacaaccc agacacccag 540 ggtggagtcc aggggcctga aggccccact cctgatgcct ctggctccag tgccaaggat 600 cctccaagct tgtttgatga tgaggtctct ttctcccagc tcttccctcc aggcggtcgc 660 ttgactagaa agaggaaccc gcgtgtctac gggaagcgct gtgagaagcc ggtgctcccg 720 ctgccaaccc agcccagctt tgaggagggc ggtgacccca cgctgggccc agcccgcctg 780 cccacggacc tcagcgactc cagctccctc tgcctctgcc atgaggaccc gtgggaggac 840 gaggatcccg caggtctgcc cgagtccttc ctcctggatg ggttcctcaa tagcagggtg 900 cctggcattg acccctgggc ccccggcctc agcctgtggg ccctggagcc cagcagggaa 960 gctggtgcag agaagctgcc ctcccactgc cccgaggacg atcggccgga ggccattcct 1020 gagctgcaca tggtcccagc ggcttggcga ggcctggaga tgccggcccc tgccgatgac 1080 tcctcctctt ctctcggaga tgtgagcccc gagcccccca gcctggagag agaacgctgt 1140 gacggtgggc ttcccgggaa cacccacctg ctgccgctcc gtgccacgga ctttgaggtg 1200 ctcagcacca agtttgagat gcaagacctg tgctttctgg gaccctttga agaccccgtg 1260 ggtctccccg gccccagctt cttagacttc gagggcacgg cgagctcaca ggggccacag 1320 agccgaagga cagaggaggc tgcaggggca gggagggccc aaggcagagg ccggccggcc 1380 aagggcaggc gggcctccta caagtgcaaa gtgtgcttcc agcgcttccg cagcctgggc 1440 gagctggacc tgcacaagct ggcccacacg cccgcgccgc cgcccacctg ctacatgtgc 1500 gtggagcgca ggtttggctc gcgggagctg ctgcgggggc acctgcagga gaggcacgcg 1560 cagagcaagg ccgggccctg ggcgtgcggc atgtgcctga agg agg tgg ccg acg 1615 Arg Arg Trp Pro Thr 1 5 tct gga tgt aca acg agc acc tgc gtg agc acg cgg tcc gct tcg ccc 166 3 Ser Gly Cys Thr Thr Ser Thr Cys Val Ser Thr Arg Ser Ala Ser Pro 10 15 20 gca ggg ggg cag gcg cgg agg tcc ttg ggg gac ctg ccc gga ggc ctg 1711 Ala Gly Gly Gln Ala Arg Arg Ser Leu Gly Asp Leu Pro Gly Gly Leu 25 30 35 gag ggc agc agc gct gtc gcc cac ctt ctg aac agc atc acg gaa ccc 1759 Glu Gly Ser Ser Ala Val Ala His Leu Leu Asn Ser Ile Thr Glu Pro 40 45 50 gcg ccc aaa cac cac agg ggc aag cgc tcc gcc ggc aag gcc gcc ggg 1807 Ala Pro Lys His His Arg Gly Lys Arg Ser Ala Gly Lys Ala Ala Gly 55 60 65 agc ccg gga gac ccg tgg ggg caa gag gga gaa gcc aag aaa gac agc 1855 Ser Pro Gly Asp Pro Trp Gly Gln Glu Gly Glu Ala Lys Lys Asp Ser 70 75 80 85 ccg ggc gag agg gcg aaa ccc cgg gca cgc agc acc ccc agc aac cca 1903 Pro Gly Glu Glu Arg Ala Lys Pro Arg Ala Arg Ser Thr Pro Ser Asn Pro 90 95 100 gac ggg gcc gcg acc cca gac agc gcc tct gcc acc gcc ctg gct gac 1951 Asp Gly Ala Ala Thr Pro Asp Ser Ala Ser Ala Thr Ala Leu Ala Asp 105 110 115 gcc ggc agc ccg ggc ccc ccc agg acg acc ccc agc ccg tcc ccc gac 19 99 Ala Gly Ser Pro Gly Pro Pro Arg Thr Thr Pro Ser Pro Ser Pro Asp 120 125 130 ccc tgg gcc ggc ggg gag ccc ctc ctg caa gcc acc ccg gtg cac gag 2047 Pro Trp Ala Gly Gly Glu Pro Leu Leu Gln Ala Thr Pro Val His Glu 135 140 145 gcc tgc aag gac ccc tcc cgc gac tgc cac cac tgc ggg aag cgc ttc 2095 Ala Cys Lys Asp Pro Ser Arg Asp Cys His His Cys Gly Lys Arg Phe 150 155 160 165 ccc aag ccc ttc aag ctg cag cgc cac ctg gcg gtg cac agc ccg cag 2143 Pro Lys Pro Phe Lys Leu Gln Arg His Leu Ala Val His Ser Pro Gln 170 175 180 cgc gtc tac ctg tgc ccc cgg tgc ccc cgg gtc tac ccc gag cac ggg Leu Arg Cys Pro Arg Cys Pro Arg Val Tyr Pro Glu His Gly 185 190 195 gag ctg ctg gca cac ctg ggc ggg gcg cac ggg ctg ctg gag cgg ccg 2239 Glu Leu Leu Ala His Leu Gly Gly Ala His Gly Leu Leu Glu Arg Pro 200 205 210 gag ctg cag cac acg ccg ctg tat gcc tgc gag ctc tgc gcc acg gtt 2287 Glu Leu Gln His Thr Pro Leu Tyr Ala Cys Glu Leu Cys Ala Thr Val 215 220 225 atg cgc atc atc atag aag aag tcc ttc gcc tgc agc tgc aac tac acc 2335 Met Arg Ile Ile Lys Lys Ser Phe Ala Cys Ser Ser Cys Asn Tyr Thr 230 235 240 245 ttc gcc aag aag gag cag ttc gac cgc cac atg aac aag cac ctc agg 2383 Phe Ala Lys Lys Glu Gln Phe Asp Arg His Met Asn Lys His Leu Arg 250 255 260 ggg ggg cgg cag ccc ttc gcg ttc cgc ggc gtg cgg agg ccg gga gcg 2431 Gly Gly Arg Gln Pro Phe Ala Phe Arg Gly Val Arg Arg Pro Gly Ala 265 270 270 g g aag gcc cgg gcc ctc gag ggc aca ctg ccc agc aaa cgg 2479 Pro Gly Gln Lys Ala Arg Ala Leu Glu Gly Thr Leu Pro Ser Lys Arg 280 285 290 cgc agg gtg gcc atg ccc ggc agt gcc cct ggg gcc ggg gag Arg Arg Val Ala Met Pro Gly Ser Ala Pro Gly Pro Gly Glu Asp Arg 295 300 305 cct cct ccc cgg gga agc agc ccc atc ctg agt gag ggc tct ctc ccg 2575 Pro Pro Pro Arg Gly Ser Ser Pro Ile Leu Ser Glu Gly Ser Leu Pro 310 315 320 325 gcc ctg ctc cac ctg tgt tcg gag gtg gct ccc agc acc acc aag gga 2623 Ala Leu Leu His Leu Cys Ser Glu Val Ala Pro Ser Thr Thr Lys Gly 330 335 340 tgg ccc gag acc cta gag agg cct gta gac ccc gtg acc cac ccg atc 2671 Trp Pro Glu Thr Leu Glu Arg Pro Val Asp Pro Val Thr His Pro Ile 345 350 355 aga ggt tgt gag ctg cca tcc aac cac cag gag tgt ccc ccg ccg tct 2719 Arg Gly Cys Glu Leu Pro Ser Asn His Gln Glu Cys Pro Pro Ser 360 365 370 ctg tct ccc ttc cca gct gcc ttg gct gat ggc aga gga gac tgc gcg 2767 Leu Ser Pro Phe Pro Ala Ala Leu Ala Asp Gly Arg Gly Asp Cys Ala 375 380 385 ctg gac gga gcc ctg gag agg cca gag aac gag gct tcc cca ggc agc 2815 Leu Asp Gly Ala Leu Glu Arg Pro Glu Asn Glu Ala Ser Pro Gly Ser 390 395 400 405 ccc ggg cct ctt ctc cag caa gct ctc ggg gca tct ctg ccg 2863 Pro Gly Pro Leu Leu Gln Gln Ala Leu Pro Leu Gly Ala Ser Leu Pro 410 415 420 cgg ccg gga gcc aga ggc caa gat gcg gag gga aag agg gct cct ctc 2911 Arg Pro Gly Ala Arg Gly Asn Ala Glu Gly Lys Arg Ala Pro Leu 425 430 435 gtg ttc tca ggg aaa cgc agg gcc ccg ggt gcc cgt ggc agg tgt gcc 2959 Val Phe Ser Gly Lys Arg Arg Ala Pro Gly Ala Arg Gly Arg Cys Ala 440 445 450 cct gac cat ttc cag gaa gac cac cta ctt cag aaa gag aag gag gtg 3007 Pro Asp His Phe Gln Glu Asp His Leu Leu Gln Lys Glu Lys Glu Val 455 460 465 tcc tca agc cac atg gtg tct gag ggg ggg ccc cgagg gc cac 3055 Ser Ser Ser His Met Val Ser Glu Gly Gly Pro Arg Gly Ala Phe His 470 475 480 485 aag ggc agc gcc acc aag cct gcg ggc tgc cag agc tca tca aag gac 3103 Lys Gly Ser Ala Thr Lys Pro Ala Gly Cys Gln Ser Ser Ser Lys Asp 490 495 500 agg tcg gca gca tcc acc ccc agc aaa gca ctc aag ttc cca gtg cac 3151 Arg Ser Ala Ala Serla Pro Ser Lys Ala Leu Lys Phe Pro Val His 505 510 515 cca agg aag gcg gtg ggg agc ctg gca ccc ggg gag ctg gcc cgt ggc 3199 Pro Arg Lys Ala Val Gly Ser Leu Ala Pro Gly Glu Leu Ala Arg Gly 520 525 530 aca gag aat ggg atg aag ccc gcc acc ccc aaa gcc aaa ccc ggc ccc 3247 Thr Glu Gly Met Lys Pro Ala Thr Pro Lys Ala Lys Pro Gly Pro 535 540 545 agc tcc cag ggc agt gga agc cct cgc ccc ggc acc aag aca gga ggt 3295 Ser Ser Gln Gly Ser Gly Ser Pro Arg Pro Gly Thr Lys Thr Gly G ly 550 555 560 565 ggc agc cag ccc cag cca gcc agc ggg cag ctc cag agc gag aca gcc 3343 Gly Ser Gln Pro Gln Pro Ala Ser Gly Gln Leu Gln Ser Glu Thr Ala 570 575 580 acc acc cca gcc aag ccc agc ttc agc cgg agc cct gca cca gag 3391 Thr Thr Pro Ala Lys Pro Ser Phe Pro Ser Arg Ser Pro Ala Pro Glu 585 590 595 agg ctc ccc gct cga gcc caa gcc aag agc tgc acc aag ggg cca agg 3439 Arg Leu Pro Ala Arg Ala Gln Ala Lys Ser Cys Thr Lys Gly Pro Arg 600 605 610 gaa gct ggt gag cag ggg ccc cac ggg agc cta ggt ccc aag gag aag 3487 Glu Ala Gly Glu Gln Gly Pro His Gly Ser Leu Gly Pro Lys Glu Lys 615 620 625 gga gag agc agt acg aag agg aaa aag ggc cag gtc cca ggg cca gcc 3535 Gly Glu Ser Ser Thr Lys Arg Lys Lys Gly Gln Val Pro Gly Pro Ala 630 635 640 645 agg agt gaa agt gtg ggg agc ttc ggg aga gcc ccc cct gac 3583 Arg Ser Glu Ser Val Gly Ser Phe Gly Arg Ala Pro Ser Ala Pro Asp 650 655 660 aag ccc ccc cgg acc cct cgg aag cag gca act ccc agc cgc gtg ctc 3631 Lys Pro Pro Arg Thr Pro Arg Lys Gln Al a Thr Pro Ser Arg Val Leu 665 670 675 ccg acc aag ccc aag ccc aac agc cag aac aaa ccc agg ccg cca cca 3679 Pro Thr Lys Pro Lys Pro Asn Ser Gln Asn Lys Pro Arg Pro Pro Pro 680 685 690 tca gag cag cgg aag gca gag ccg ggc cac aca cag agg aag gac aga 3727 Ser Glu Gln Arg Lys Ala Glu Pro Gly His Thr Gln Arg Lys Asp Arg 695 700 705 ctg ggc aag gcc ttc ccc cag ggg aga ccc ctg ctc agg ccc cccag Gly Lys Ala Phe Pro Gln Gly Arg Pro Leu Leu Arg Pro Lys 710 715 720 725 agg ggc aca gct gtc cac ggt gct gaa cct gcc gag ccg cac acc cac 3823 Arg Gly Thr Ala Val His Gly Ala Glu Pro Ala Glu Pro His Thr His 730 735 740 cgg acg gcc gag gcc cag agt gac ctc ctc agc cag ctc ttc ggg cag 3871 Arg Thr Ala Glu Ala Gln Ser Asp Leu Leu Ser Gln Leu Phe Gly Gln 745 750 755 aga cta act ggc ttc aaa atc aag aaa gat gct tct gag 3916 Arg Leu Thr Gly Phe Lys Ile Pro Leu Lys Lys Asp Ala Ser Glu 760 765 770 taatttctag aagcaagagc ctgggaccgg agctgggcgt tcctgtctcg gcctgcctcc 3976 ttggccag ccggct ccggct atggtcc actctgtggc cacttgactt cttgtgcaac 4036 tgctcaggcc ttgatgtcag agctgaggtg gtgatgcttt gaacagggcc caggtgggca 4096 gcattccctt tcttgctgga aggctggggg tgaaagacgg ggccactgca gcccttttga 4156 gaccacacag ctgttttctt ggtaccaagt acttgaagag acagcagccc atcccctcag 4216 cccacacccc tgcgccctgt gggcaccgac accacagaag ccaatgtttg gagatttgca 4276 caacctcccg ttcccccaca tggagaaggg aagtaagttg aggcagccgt gggatggtgg 4336 taggttccct cttagtcttg ctgctgttgc tggaattcca aagtgacctt agaaaccacg 4396 tgggggaagg cagtgctcac tacttagaag ggttgcttct gagccgcctg gtcccccaag 4456 agcacaacag gcctcctccc tctgaccaca gggtcatgcc tcctccctct gaccacaggg 4516 tcatgcctcc tccctctgac cacagggtca tgccagcctc catttgcgct gcgggagaaa 4576 agcccatctc tagcacacct tgaccccagg aaccgggttc ccgtatggaa ctgggaagaa 4636 accgcccctg tgccagctcc cgcgggccct cctcgttccc tcccagcctc catggccgcc 4696 ctctagagcc tccctgctgt acggagctct gggctccacc tatttgcaat gttactctga 4756 agtttctggt gctatttttg tgttgtaatg tgaatacagg cttccttgat ttttttttta 4816 atgggggtat tgggtgggac agacgggg tc agggaggccc caccatggct tgtcgagggc 4876 acgggcacct gcatggcggc gctctccctg cctcccctgc cgggctgcaa gcctgaggtc 4936 tgtgctgccg gacggggatg ctcagggctg gggctgcaga gccgctgccc tggccagggc 4996 accctcatgc accgacccaa cccaggcctg ggacgcacgt gtcctctcac agcgtcgtgc 5056 ctgtgaaggt gggtcaaagg gtgagagggc ttccttctca cccttctctc cataagtatc 5116 ttgaagatcc atggtttgtt ttgctctatt gtttagtttt tacttgggtg caatgtgtac 5176 gtcaaaagtt tttattttga tatttgaaag agaccaaatc aggcccagac cgcctctctg 5236 gaaggtgttg taggccattc aaaacgcctc cggagtgtcg caaaccaagt gcggaggggc 5296 cctgaggttg tactgtaaac atcatagtga cttgtctttt caaatatatt cccactattt 5356 tcgc 5360 <210> 57 <211> 4993 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (247) .. (3399) <400> 57 ggccgggctt ggctggctct cattcgaaga ggcagcagag acctacctgg ggactgcttt 60 gggcctgatt aaggggaatc cttagaattt ggctaggcca cagaggggga tatctggcat 120 ccactgagct tgaagggcag gaacagggga caggagagat caggacgatc gtcttgggag 180 ggcgcatctg gggaagctca gaaattggac tagggcagga ggcctctggg atctggcaga 240 agttaa ggg cag agt gtc ggg gga agg gga ctc ttc agg gac tgt gcc 288 Gly Gln Ser Val Gly Gly Arg Gly Leu Phe Arg Asp Cys Ala 1 5 10 tgc ata gaa gag acc acg ggg gcc ggg gcg cta tca cgg tct ggg gcg 336 Cys Ile Glu Glu Thr Thr Gly Ala Gly Ala Leu Ser Arg Ser Gly Ala 15 20 25 30 ggg ccc ctg gat gtg gag gcg gct ggg ccc tcg ccc agc cgc tgc gag 384 Gly Pro Leu Asp Val Glu Ala Ala Gly Pro Ser Pro Ser Arg Cys Glu 35 40 45 gga ggt gga agc ctt cgg gct cgg agc cgg gg ca cgg cat ggg cca 432 Gly Gly Gly Ser Leu Arg Ala Arg Ser Arg Gly Gln Arg His Gly Pro 50 55 60 ccc tgg gac gag ggc tct tcg ctg ggt ccc atg agg atc cgc cgg gcc 480 Pro Trp Asp Glu Gly Ser Ser Leu Gly Pro Met Arg Ile Arg Arg Ala 65 70 75 ccg ccg ccg ccg cct gtg gcc cgt ttc cac atc ccc cct ccc gcg ctc 528 Pro Pro Pro Pro Pro Val Ala Arg Phe His Ile Pro Pro Pro Ala Leu 80 85 90 ccg agc ccg cga ctg cgc ggc cga gga tgg cgc agc tgg cgg gga ccc 576 Ser Pro Arg Leu Arg Gly Arg Gly Trp Arg Ser Trp Arg Gly Pro 95 100 105 110 cgc act tgg gcg ggc gtg gat cgg agg cct ccg cct gtc cgc cga ggg 624 Arg Thr Trp Ala Gly Val Asp Arg Arg Pro Pro Pro Val Arg Arg Gly 115 120 125 cgt tcc cgt cgt cat gcg gcc acc gcg gcc tca ggg gct cca cct ggg 672 Arg Ser Arg Arg His Ala Ala Thr Ala Ala Ser Gly Ala Pro Pro Gly 130 135 140 tct cac acg gag ccc cag aga ccc agc gct gac ccc ggc ccc tac ctc 720 Ser His Thr Glu Pro Gln Arg Pro Ser Ala Asp Pro Gly Pro Tyr Leu 145 150 155 cgc agc ttg cct tgc gcc atg gac tgg cag cca gac gag cag ggc ctg 768 Arg Ser Leu Pro Cys Ala Met Asp Trp Gln Pro Asp Glu Gln Gly Leu 160 165 170 cag cag gtc ctg cag ctg ctc aaa gac tca cag tcg ccc aac aca gcc 816 Gln Gln Val Leu Gln Leu Leu Lys Asp Ser Gln Ser Pro Asn Thr Ala 175 180 185 190 ac t cag cgc atc gtg cag gat aaa ctc aaa caa ctc aat cag ttt cct 864 Thr Gln Arg Ile Val Gln Asp Lys Leu Lys Gln Leu Asn Gln Phe Pro 195 200 205 gac ttc aac aac tac ctg att ttc gtc ctg acc aga tca gaa 912 Asp Phe Asn Asn Tyr Leu Ile Phe Val Leu Thr Arg Leu Lys Ser Glu 210 215 220 gat gag cca acg cgc tct ctc agt ggc ctc atc ctc aag aac aac gtg 960 Asp Glu Pro Thr Arg Ser Leu Ser Gly Ile Leu Lys Asn Asn Val 225 230 235 aag gca cac tat cag agc ttc cca ccc cct gtg gca gac ttc atc aaa 1008 Lys Ala His Tyr Gln Ser Phe Pro Pro Pro Val Ala Asp Phe Ile Lys 240 245 250 cag gag tgt ctc aac aac att ggc gat gcc tcc tcg ctc atc cga gcc 1056 Gln Glu Cys Leu Asn Asn Ile Gly Asp Ala Ser Ser Leu Ile Arg Ala 255 260 265 270 acc att ggc att ctc atc acc acc atc gct tcc aag ggt gag ctg cag 1104 Thr Gly Ile Leu Ile Thr Thr Ile Ala Ser Lys Gly Glu Leu Gln 275 280 285 atg tgg ccc gag ctg ctg ccc cag ctc tgc aac ctg ctt aac tcg gag 1152 Met Trp Pro Glu Leu Leu Pro Gln Leu Cys Asn Leu Leu Asn Ser u 290 295 300 gat tac aac act tgt gag gga gcc ttt gga gcc ctg cag aag atc tgt 1200 Asp Tyr Asn Thr Cys Glu Gly Ala Phe Gly Ala Leu Gln Lys Ile Cys 305 310 315 315 gaa gac tca tca gag ctt ctg gac agt gac gcc ctc aac agg ccc ctc 1248 Glu Asp Ser Ser Glu Leu Leu Asp Ser Asp Ala Leu Asn Arg Pro Leu 320 325 330 aac atc atg atc ccc aag ttc ctg cag ttc ttc aag cac tgc agt ccc 1296 Asn Ile Phe Lys Leu Gln Phe Phe Lys His Cys Ser Pro 335 340 345 345 350 aag atc cgg tcc cac gcc atc gcc tgc gtg aac cag ttc atc atg gac 1344 Lys Ile Arg Ser His Ala Ile Ala Cys Val Asn Gln Phe Ile Met Asp 355 360 365 cgg gcc cag gcg ctg atg gac aat att gac acc ttc atc gag cac cta 1392 Arg Ala Gln Ala Leu Met Asp Asn Ile Asp Thr Phe Ile Glu His Leu 370 375 380 ttt gcc ctg gct gtg gat gat gac ccc gag agg tgg tgc 1440 Phe Ala Leu Ala Val Asp Asp Asp Pro Glu Val Arg Lys Asn Val Cys 385 390 395 cgt gcc ctg gtg atg ctt ctg gaa gtg cgg att gac agg ctc atc ccc 1488 Arg Ala Leu Val Met Leu Leu Glu Val Arg Asp Arg Leu Ile Pro 400 405 410 cac atg cac agc atc atc cag tac atg ctg cag agg acc cag gac cat 1536 His Met His Ser Ile Ile Gln Tyr Met Leu Gln Arg Thr Gln Asp His 415 420 425 430 gat gag aac gtt gcc ctt gag gcc tgt gag ttc tgg ctg acg ctg gcc 1584 Asp Glu Asn Val Ala Leu Glu Ala Cys Glu Phe Trp Leu Thr Leu Ala 435 440 445 gag cag ccc atc tgc aag gaa gtc ctg gcc tcc cat ctg gtg cag Pro Ile Cys Lys Glu Val Leu Ala Ser His Leu Val Gln Leu 450 455 460 atc ccc atc ttg gtg aat ggg atg aag tac tcg gaa att gac atc atc 1680 Ile Pro Ile Leu Val Asn Gly Met Lys Tyr Ser Glu Ile Asp Ile Ile 465 470 475 ctg ctc aag ggg gat gtg gag gag gat gag gct gtc ccc gac agt gag 1728 Leu Leu Lys Gly Asp Val Glu Glu Asp Glu Ala Val Pro Asp Ser Glu 480 485 490 490 cag gac atc aag cca cgc ttc cac ag acg gtc aca ctg ccc 1776 Gln Asp Ile Lys Pro Arg Phe His Lys Ser Arg Thr Val Thr Leu Pro 495 500 505 510 cac gag gct gag cgg cct gat ggc tcc gag gac gcg gag gat gac gat 1824 His Glu Ala Glu Arg Pro Asp Gly Ser Glu Asp Ala Glu Asp Asp Asp 515 520 525 gat gat gat gct ctg tcc gac tgg aat ttg agg aag tgc tca gcg gct 1872 Asp Asp Asp Ala Leu Ser Asp Trp Asn Leu Arg Lys Cys Ser Ala Ala 530 gca ctg gac gtc ctc gcc aat gtc ttc cgg gag gaa ctg ctg ccc cac 1920 Ala Leu Asp Val Leu Ala Asn Val Phe Arg Glu Glu Leu Leu Pro His 545 550 555 cta ctc cca cta ctc aaa ggc ctc cc ccc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc gtg gtc 1968 Leu Leu Pro Leu Leu Lys Gly Leu Leu Phe His Pro Glu Trp Val Val 560 565 570 aag gag tcg ggc atc ctg gtg ctg ggc gcc att gct gag ggc tgc atg 2016 Lys Glu Ser Gly Ile Leu Val Leu Gly Ala Glu Gly Cys Met 575 580 585 590 590 cag ggc atg gtg ccc tac ctg cct gag ctg atc ccg cac ctg atc cag 2064 Gln Gly Met Val Pro Tyr Leu Pro Glu Leu Ile Pro His Leu Ile Gln 595 600 605 tgc gct ctg aag gcc ttg gtc cgc tcc atc gcc tgc tgg acg 2112 Cys Leu Ser Asp Lys Lys Ala Leu Val Arg Ser Ile Ala Cys Trp Thr 610 615 620 ctg agc cgc tat gcc cac tgg gtg gtc agc cag cca ccc gac atg Leu Ser Arg Tyr Ala His Trp Val Val Ser Gln Pro Pro Asp Met His 625 630 635 ctc aag ccc ctg atg aca gag ctg ctc aaa cgc atc ctg ctg gat ggc aac 2208 Leu Lys Pro Leu Met Thr Glu Leu Leu Lys Arg Ile Leu Asp Gly Asn 640 645 650 aag agg gta cag gag gcg gcc tgc agt gct ttt gcc acc ctg gag gaa 2256 Lys Arg Val Gln Glu Ala Ala Cys Ser Ala Phe Ala Thr Leu Glu Glu 655 660 665 670 gag gcc tgc acg gag cc tac ctc agc tac atc ctg gac acc 2304 Glu Ala Cys Thr Glu Leu Val Pro Tyr Leu Ser Tyr Ile Leu Asp Thr 675 680 685 ctt gtc ttt gcc ttt ggg aaa tac cag cac aag aac ctg ctc atc ctc 2352 Leu Val Phe Ala Gly Lys Tyr Gln His Lys Asn Leu Leu Ile Leu 690 695 700 tat gac gcc att ggc acc ctg gcc gac tct gta ggc cac cac ctc aac 2400 Tyr Asp Ala Ile Gly Thr Leu Ala Asp Ser Val Gly His His Leu Asn 705 710 715 cag ccg gaa tac atc cag aag ctg atg ccc cca ctg atc cag aag tgg 2448 Gln Pro Glu Tyr Ile Gln Lys Leu Met Pro Pro Leu Ile Gln Lys Trp 720 725 730 aat gag ctc aag gac gaa gac aag gac ccc ctctt g ctg gag tgt 2496 Asn Glu Leu Lys Asp Glu Asp Lys Asp Leu Phe Pro Leu Leu Glu Cys 735 740 745 750 ctg tca tcg gtg gcc acc gcc ctg cag agt ggc ttc ctg cct tac tgt 2544 Leu Ser Ser Val Ala Thr Gln Ser Gly Phe Leu Pro Tyr Cys 755 760 765 gag ccc gtc tac cag cgc tgt gtc acc ctg gtg cag aag aca ctg gct 2592 Glu Pro Val Tyr Gln Arg Cys Val Thr Leu Val Gln Lys Thr Leu Ala 770 775 780 780 gag atg atg tac acc cag cac cct gag cag tat gag gct ccc gac 2640 Gln Ala Met Met Tyr Thr Gln His Pro Glu Gln Tyr Glu Ala Pro Asp 785 790 795 aag gac ttc atg atc gta gca ctg gat ctg ctc agc ggc ctg gcc Lys Asp Phe Met Ile Val Ala Leu Asp Leu Leu Ser Gly Leu Ala Glu 800 805 810 ggc ctg ggt ggt cac gtg gag cag ctg gtg gcc cgc agc aac atc atg 2736 Gly Leu Gly Gly His Val Glu Gln Leu Val Ala Serg Ile Met 815 820 825 830 aca ttg ctg ttc cag tgc atg cag gac tcg atg cct gag gtc cgg cag 2784 Thr Leu Leu Phe Gln Cys Met Gln Asp Ser Met Pro Glu Val Arg Gln 835 840 845 agc tcc ttt gcc gct gac ctc acc aaa gcc tgc ttc atc cat 2832 Ser Ser Phe Ala Leu Leu Gly Asp Leu Thr Lys Ala Cys Phe Ile His 850 855 860 gtc aag ccc tgt atc gcc gag ttc atg ccc att ctg ggc acc aac ctg 2880 Val Lys Pro Ile Ala Glu Phe Met Pro Ile Leu Gly Thr Asn Leu 865 870 875 aac cca gag ttc atc tcc gtc tgc aac aac gcc acc tgg gcc att ggt 2928 Asn Pro Glu Phe Ile Ser Val Cys Asn Asn Ala Thr Trp Ala Ile Gly 880 885 885 890 gaa atc tgc atg cag atg ggg gca gag atg cag cct tat gtg cag atg 2976 Glu Ile Cys Met Gln Met Gly Ala Glu Met Gln Pro Tyr Val Gln Met 895 900 905 910 gtc ctc aac aac ctg gtg gac atc atc gac atc aac aca ccc aag 3024 Val Leu Asn Asn Leu Val Glu Ile Ile Asn Arg Pro Asn Thr Pro Lys 915 920 925 aca ctg ctg gaa aac aca gcc atc acc atc ggc cgc ttg ggc tac gtg 3072 Thr Leu Leu Glu Asn Thr Ala Ile Gly Arg Leu Gly Tyr Val 930 935 940 tgc ccc cag gag gtg gca ccc atg ctg cag cag ttc atc cgg cct tgg 3120 Cys Pro Gln Glu Val Ala Pro Met Leu Gln Gln Phe Ile Arg Pro Trp 945 950 955 tgc acg tcc ctc agg aac atc agg gac aac gag gag aag gac tca gcc 3168 Cys Thr Ser Leu Arg Asn Ile Arg Asp Asn Glu Glu Lys Asp Ser Ala 960 965 970 ttc cgc ggc atc tgc atg atg atc ggt gtc ggg ggg gtt 3216 Phe Arg Gly Ile Cys Met Met Ile Gly Val Asn Pro Gly Gly Val Val 975 980 985 990 cag gac ttt att ttc ttc tgc gat gct gta gcc tcc tgg gtg agc ccg 3264 Gln Asp Phe Ile Phe Phe Cys Asp Ala A Trp Val Ser Pro 995 1000 1005 aag gat gac ctt cgg gac atg ttt tat aag att ctt cac ggc ttc aaa 3312 Lys Asp Asp Leu Arg Asp Met Phe Tyr Lys Ile Leu His Gly Phe Lys 1010 1015 1020 gac caa gtt ggg gaa gat ag tgg cag cag ttc tct gag caa ttc ccg 3360 Asp Gln Val Gly Glu Asp Asn Trp Gln Gln Phe Ser Glu Gln Phe Pro 1025 1030 1035 ccg ctg ctc aag gag agg ctg gcg gct ttc tat ggg gtc Taggtgatg Lyc ger Leu Ala Ala Phe Tyr Gly Val 1040 1045 1050 tggagactgc caggtttctg tctgcgtcgt cgtcggaggg attactgggg agtgcgctgc 3469 atccggaagt cgctgtgccc tggttgaggg gggttaggga ggagtgagtg ggactcaaa t 3529 ccagatgcct tccccgtccg tccgtccgtc cgtccatccg tccacttgcc ctcctggcag 3589 gtgggtgggg ccaccatgct catcctacaa acggggaggt gggggggact tctggtgggc 3649 aagggcccct gggctctaat agggtcatct ctggcagccc acttgggcca gctacgtggg 3709 agggaggaat tacacagctg accgaatccg gcttcggatg aggtgaggga ggagcaggtc 3769 aggagggggg ccctcgtagg gacgcgtaca ctcacacgga cacacatggc cacacgcatg 3829 tgcgggtgcc ataaccggcg aggctgggcc agccgctcca ccatttcccc gactgcatgg 3889 agacagtaga attagtgaac ccctgagtta acccgtaagg ccttccgtgt aacctgcatc 3949 tagagtttaa gaagcttctg ctgttttgcc ggaattggcg gtgactgggg agggctgggt 4009 gggtgggggg cctcaggcgg gatctcgggg cggggggagg aggatggtga ccttgggagt 4069 cgccctgtca gcacgcacat gcttgggacc cactccacac actccctgcc agctttgttg 4129 cagcctcagc tggtggtgtc tccgtcctta tcctagccta gctcgcaggg tgagaaccac 4189 tggagtggct ggggctggcc agaggtcacc gtttctcctt cctgtgtgct ccagtggctt 4249 ttgaagacac tgggttggga cctttttcct gaagagagct gggtgtagcc agagctactg 4309 gcacctaccc cgagcatctc tctctgtaag cagcttcagg ggcagtccgt ttctctgtgc 436 9 ttctgaaacc cccttctcac gtttcaggcc ccagttttaa ctcaaggcct ggggcagggg 4429 cgtttaattg atgatgacag aggacacagg tttttgccag caaaaaggaa aaccaaggct 4489 tggtggaagg gaaaggtggt gtgtcccctg ttccctattc catctccctg ggacttcctg 4549 ctcatcatag tacccagtga gcccagagat cctactagac tgggtcagca attctagaga 4609 accttccgga atagtctggg aacatggtca aggtggaagg ggctccccta gagagggtgg 4669 gggtgtagtt acttcccagt tggccagaaa actgggcctt gcagaccccc ttagcatttt 4729 ttcccttttt ttccttccct gctttctact tctttgggga gccccttgtg ttttggagtc 4789 tgactggagt ctcgcatcct ggggcctgct ccatccatcc ctcctgggcg ccagaccctc 4849 catccaagcc ctgtgtcttt ccatagtcag ggtcaggccc tgcatctatt ccaaggggca 4909 ctcagtac tacct gccctcgt gcccct gccct gccctc gtc gcccct gccctc gtc gccctc gtc gccctc <210> 58 <211> 5240 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1597) <400> 58 a caa cgg aaa ctt gag caa cat aag gat ctg ctt caa aac acg gat gcc 49 Gln Arg Lys Leu Glu Gln His Lys Asp Leu Leu Gln Asn Thr Asp Ala 1 5 10 15 cac aaa aga gca ttc cat gaa atc tac cgg acc agg tct gtt aac ggg 97 His Lys Arg Ala Phe His Glu Ile Tyr Arg Thr Arg Ser Val Asn Gly 20 25 30 att cca gtg cca cct gat caa tta gag gac atg gcc gag agg ttt cat 145 Ile Pro Val Pro Pro Asp Gln Leu Glu Asp Met Ala Glu Arg Phe His 35 40 45 ttt gtt tcc tcc aca tca gag cta cac cta atg aaa atg gaa ttt 193 Phe Val Ser Ser Thr Thr Ser Glu Leu His Leu Met Lys Met Glu Phe Leu 50 55 60 gaa tta aag tac cgt ctg ctc tca ctg ctg gtt ctt gca gag tca aag 241 Glu Leu Lys Tyr Arg Leu Leu Ser Leu Leu Val Leu Ala Glu Ser Lys 65 70 75 80 ctg aag tct tgg atc att aag tac ggg agg aga gag gtg gag cag 289 Leu Lys Ser Trp Ile Ile Lys Tyr Gly Arg Arg Glu Ser Val Glu Gln 85 90 95 ctt cta caa aac tac gtg tct ttt ata gaa aat agc aag ttc ttt gaa 337 Leu Leu Gln Asn Tyr Val Ser Phe Ile Glu Asn Ser Lys Phe Phe Glu 100 105 110 caa tat gag gtg aca tac cag atc ttg aaa cag aca gct gag atg tat 385 Gln Tyr Glu Val Thr Tyr Gln Ile Leu Lys Gln Thr Ala Glu Met Tyr 115 120 125 gtc aaa gca gat ggt tca gtg gaa gct gag agat atg aaa ttc 433 Val Lys Ala Asp Gly Ser Val Glu Glu Ala Glu Asn Val Met Lys Phe 130 135 140 atg aat gaa acc acc gct cag tgg agg aat ctc tca gta gaa gtg agg 481 Met Asn Glu Thr Thr Ala Gln Trp Arg Asn Leu Ser Val Glu Val Arg 145 150 155 160 agt gtg agg agc atg ctg gaa gaa gtg atc tct aac tgg gat cgc tat 529 Ser Val Arg Ser Met Leu Glu Glu Val Ile Ser Asn Trp Asp Arg Tyr 165 170 175 ggc aat acagt gct agt ctg caa gcc tgg cta gag gat gct gaa aaa 577 Gly Asn Thr Val Ala Ser Leu Gln Ala Trp Leu Glu Asp Ala Glu Lys 180 185 190 atg ctc aat caa tca gaa aat gcc aaa aag gat ttt ttt cga aat tta625 Leu Asn Gln Ser Glu Asn Ala Lys Lys Asp Phe Phe Arg Asn Leu 195 200 205 cct cat tgg att cag cag cat act gcc atg aac gat gct ggc aat ttt 673 Pro His Trp Ile Gln Gln His Thr Ala Met Asn Asp Ala Gly AsnPhe 210 215 220 cta att gaa acc tgt gat gag atg gtt tcc cgt gac ctg aag cag caa 721 Leu Ile Glu Thr Cys Asp Glu Met Val Ser Arg Asp Leu Lys Gln Gln 225 230 235 240 tta ctg ttg cta aat ggg cgg tgg agg gag ttg ttt atg gaa gtc aag 769 Leu Leu Leu Leu Asn Gly Arg Trp Arg Glu Leu Phe Met Glu Val Lys 245 250 255 caa tat gct caa gct gat gag atg gac aga atg aag aag gaa tac aca 817 Gln Tyr Ala Gln Glu Met Asp Arg Met Lys Lys Glu Tyr Thr 260 265 270 gac tgt gtt gtt acc ctg tct gct ttt gca acg gaa gcc cat aag aaa 865 Asp Cys Val Val Thr Leu Ser Ala Phe Ala Thr Glu Ala His Lys Lys 275 280 285 ctt tct gaa ccc tta gaa gtc tct ttt atg aat gtc aag cta tta att 913 Leu Ser Glu Pro Leu Glu Val Ser Phe Met Asn Val Lys Leu Leu Ile 290 295 300 caa gac ttg gag gat att gag cag agg gtg cct gtg atg caa 961 Gln Asp Leu Glu Asp Ile Glu Gln Arg Val Pro Val Met Asp Ala Gln 305 310 315 320 tac aag ata att aca aag aca gca cac ctc att acc aaa gaa agc ccc 1009 Tyr Lys Ile Ile Thr Lys Thr Ala His Leu Ile Thr Lys Glu Ser Pro 325 330 335 caa gaa gaa gga aaa gaa atg ttt gcg acc atg tca aag ctc aaa gag 1057 Gln Glu Glu Gly Gly Lys Glu Met Phe Ala Thr Met Ser Lys Leu Lys Glu 340 345 350 350 cag cta acc aag gtcaaa gaa tgt tac tcc cca ctc ctt tat gag tct 1105 Gln Leu Thr Lys Val Lys Glu Cys Tyr Ser Pro Leu Leu Tyr Glu Ser 355 360 365 cag cag ctg ttg att ccg ttg gag gaa tta gaa aag cag atg acg tcc 1153 Gln Leu Ile Pro Leu Glu Glu Leu Glu Lys Gln Met Thr Ser 370 375 380 ttt tat gac tca ctt ggg aaa atc aat gaa att atc aca gtt ctt gag 1201 Phe Tyr Asp Ser Leu Gly Lys Ile Asn Glu Ile Ile Thr Val Leu Glu 385 390 395 400 cgt gag gca caa tcg agt gcc ctt ttt aaa caa aaa cat cag gaa ctg 1249 Arg Glu Ala Gln Ser Ser Ala Leu Phe Lys Gln Lys His Gln Glu Leu 405 410 415 tta gct tgt caa gaa aac tgt aag aaa acctt aca ctt att gag aaa 1297 Leu Ala Cys Gln Glu Asn Cys Lys Lys Thr Leu Thr Leu Ile Glu Lys 420 425 430 ggc agt caa agt gtt caa aag ttt gtg acc ttg agc aac gtg tta aag 1345 Gly Ser Gln Ser Val Gln Lys Phe Val Thr Leu Ser Asn Val Leu Lys 435 440 445 cat ttt gat cag acg agg cta caa aga cag att gca gat att cat gtt 1393 His Phe Asp Gln Thr Arg Leu Gln Arg Gln Ile Ala Asp Ile His Val 450 455 460 gct ttt cag agt atg gta aag aaa act gga gat tgg aag aag cat gtg 1441 Ala Phe Gln Ser Met Val Lys Lys Thr Gly Asp Trp Lys Lys His Val 465 470 475 475 480 gaa acc aac agt cgc ttg atg aag aag ttt gag gag tct cga gca gag 1489 Glu Thr Asn Ser Arg Leu Met Lys Lys Phe Glu Glu Ser Arg Ala Glu 485 490 495 ttg gag aag gta ctg cgg att gct cag gag ggc ctg gag gaa aag ggg 1537 Leu Glu Lys Val Leu Arg Ile Ala Gln Leu Glu Glu Lys Gly 500 505 510 gat cca gag gag ctc ctg cgg aga cac act gtg agt cca ccc ttt agg 1585 Asp Pro Glu Glu Leu Leu Leu Arg Arg His Thr Val Ser Pro Pro Phe Arg 515 520 525 gga cac ttg acc tgaatacatgac cttggaggaa agcttaaaaa 1637 Gly His Leu Thr 530 aggcatgctg atctgataca gaaggagagc gggcagatga gtcagggaag cagagacttt 1697 ttaggtatga gacccaaaga tatggtgagc aaaaagaact tcaagagagt tggtgag ctg 1757 acttgtcatt ggccattcct aagtccccag aatagtagac agtcatagaa taattcaagt 1817 tatccaaatt actaattcat tatttagctt gcaaattctt ctataactaa agattctttt 1877 aaacagataa ctcgaggtga ctagctaagt cctttgtgct cattttatac attcaccata 1937 tcatagtata gatactgtgt cacttgaagt ctggtggctg atacacaact tgtcccagta 1997 tcttcatgtt tatcatcttc atgtttatca tgaaaagcca tcttcatgtt tatcatctca 2057 atatcaatat tgggaatatt agtcataatg ttcatgaatg gtatatggaa ataaccagca 2117 ctctgagaac atgtatttga gttatctttc ctgacatttc agtggctatt tgtataaacc 2177 acactctcaa atgatatatg caatgtattt gtgattctgc agactagatt tagggttaat 2237 gtctgtgacc acaaaacaca aaatatctca ttcagtttat tcacctctac agtatggtac 2297 ttcttgtttt gaatcaccgt ttttacaaaa taattctgca tgtctactcc tgagactgtg 2357 tgagacttag tcatatgtaa tatgtgcatg tgtattgtct ttatctactt gactgccaga 2417 gcaaaatgcc atagacgggt ggctaaagca acagaaactt atgttctcac agttctggag 2477 aagggaaatc tgtgatcagg tgctagtata gtagggttct ggggagggcc ctcttcctgg 2537 cttgcagatg gctacctttt ccctgtgccc tcacatggca gagagagtga gctagcaagc 2 597 tttctggtgt ccctcctcat aagcgcacta atcctatcat gaggacccca tccccatgac 2657 ctcatctgaa cctaaccacc ttccaaagtt cccatctcca aataccatat gagtctgaag 2717 aagaacacaa tttggtgcta gcatgtgtgc ctatgtgtgc acatgtgtgc ttctgtgtgc 2777 acatgtgtgc ttctgtgtgc acatgtgtgc ttctgtgtgc acatgtgtga atgtgacaat 2837 ggctcatgat gaagcatcag gccctgaagc actgtggttg gggaatgtgg aattatgaag 2897 cttagtcctg gcttctgttc tgttcttctg acttcaccaa aggggaaccg aagctctatc 2957 gctacagaat caaggttttg gcatctcccc ttggaagatg agatattcct tttggaatat 3017 tctaccaaat ttgaaaatca caaagaattt ttctaaaaaa taaaaaatac tagtagaatt 3077 tcagatatga tggcttctga ttcataacta taggtgcaca tagttcatcc ttaaaaaaca 3137 atagtgggtg cctggaagtc tgcaagaggg cagcagctgg ctgagaggct tgtttggagg 3197 cttagaggct gattgtgcct ggtgctgcct tttcgtctgt ccaacactct tacccacttt 3257 ccccttccat gtcaggagtt tttcagtcag ctggatcaga gggtgctcaa tgctttcctg 3317 aaagcttgtg atgaactcac cgacatcctt ccagagcagg agcagcaggg gctgcaggaa 3377 gctgttcgaa agctccacaa acaatggaag gatcttcaag gagaagcccc ttatcatttg 3437 ct tcatctga agattgatgt ggagaagaat aggttcttag cctctgtaga agaatgcaga 3497 actgagctgg atcgagagac caagctgatg ccccaggaag gcagtgaaaa gataattaaa 3557 gagcacaggg ttttcttcag tgacaaaggt cctcatcatc tctgtgagaa aaggttacag 3617 ctcatcgagg aactctgtgt gaaactccca gtgcgggacc cagtaaggga cacacctgga 3677 acctgtcacg tgactctcaa agagctcaga gctgccattg acagcaccta caggaagctc 3737 atggaagacc cagacaagtg gaaggactac actagcagat tctctgagtt ctcatcttgg 3797 atatctacaa atgagacaca attaaagggg atcaagggtg aggccatcga tactgccaac 3857 cacggagagg ttaaacgtgc cgttgaagag atcagaaatg gtgttaccaa aaggggtgag 3917 accctcagct ggctgaaatc caggctgaaa gttttgacag aagtttcttc tgagaatgaa 3977 gcccaaaagc agggagatga gctggcaaaa ttatccagct ctttcaaggc tcttgtgacg 4037 ctgctgtcag aggttgaaaa gatgctaagc aattttgggg actgtgtcca gtacaaagaa 4097 atagtcaaaa attctctcga agaattaatt tctggctcta aagaagtcca ggaacaagct 4157 gagaagatct tggatactga aaatctgttt gaagcacagc agttacttct tcatcaccag 4217 caaaagacaa agcggatctc agcaaagaag agagatgtgc agcagcagat cgcgcaggcg 4277 cagcagg gag aaggggggct gcctgaccga ggccacgagg agctgcggaa gctggagagc 4337 acactggatg gcctggagcg cagccgggag aggcaggaac gccgcatcca ggtcacatta 4397 agaaaatggg agcgatttga aacaaacaaa gaaacagtag taagatacct ttttcaaaca 4457 ggttccagtc atgaacgctt cttgagtttt agcagtttgg aaagtttatc ttcagaactg 4517 gaacaaacaa aggagttttc taaacggaca gaaagtattg cagtccaggc tgagaacctt 4577 gtaaaggaag cttcagagat accgcttggg ccccaaaata agcagctgct tcaacagcag 4637 gccaagtcaa tcaaagaaca agtcaaaaaa ttagaagaca cgcttgaaga agagtatgtg 4697 attgacaagt cctaaacttt cttctctgag ataaagtttc atacaatctt tcctgtacct 4757 tgtattcaaa acactctttt aaaatctcaa agtgtctgtg tatttcagca tgttttgagg 4817 aaacaactca cagttcaaaa gaaagtatcg ctaatacaga aaccaatatc tataacagag 4877 cccaaaaaat ataaaggatg tgggttttgc atcttaaact gatcatgttc atgagaaagc 4937 catatctatt ctattctgtg gcctttgtac attgtagagg gaatcttgaa aaagaactaa 4997 tatttaaaat aattttttta ctatattatt ctgctgtcac catttagagc gaaaaggaga 5057 tattttgtta gtgtagattc caggcctaaa tacacatcac atagaccata tatctccaac 5117 ctgaagaagc tc ctggagct tgtttacagt gcctcggtat tcaagttatc ctgactaata 5177 tgctctttcc agaaattaac tttaaaatat tttattttta aacttttaat gtttgtttat 5237 ctg 5240 <210> 59 <211> 5256 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1316) <400> 59 cg cca ttg gag ttc ccg aga agc tgc ttc acc ctc cct ctc agg ctg 47 Pro Leu Glu Phe Pro Arg Ser Cys Phe Thr Leu Pro Leu Arg Leu 1 5 10 15 agc tct cat ctc cct ggg acc cgc agc atg gct gag gga agc ttc agc 95 Ser Ser His Leu Pro Gly Thr Arg Ser Met Ala Glu Gly Ser Phe Ser 20 25 30 gtg caa tcg gaa agc tac agt gtt gaa gac atg gat gag ggt agc gac 143 Val Gln Ser Glu Ser Tyr Ser Val Glu Asp Met Asp Glu Gly Ser Asp 35 40 45 gaa gtc ggg gag gaa gag atg gtt gaa ggc aac gac tat gaa gaa ttc 191 Glu Val Gly Glu Glu Glu Met Val Glu Gly Asn Asp Tyr Glu Glu Phe 50 55 60 ggt ttt ggt ggc tat ggc acc ctc acc agc ttt gac atc cat atc 239 Gly Ala Phe Gly Gly Tyr Gly Thr Leu Thr Ser Phe Asp Ile His Ile 65 70 75 ctc aga gcc ttc gga agc ttg ggt cca ggc ctt cgc atc tat c 287 Leu Arg Ala Phe Gly Ser Leu Gly Pro Gly Leu Arg Ile Leu Ser Asn 80 85 90 95 gag ccc tgg gaa ctg gaa aac cct gtg ctg gcc cag acc ctg gtg gag 335 Glu Pro Trp Glu Leu Glu Asn Pro Val Leu Ala Gln Thr Leu Val Glu 100 105 110 gca ttg cag ctg gat ccg gaa aca ctt gcc aat gag acg gcc gcc cgt 383 Ala Leu Gln Leu Asp Pro Glu Thr Leu Ala Asn Glu Thr Ala Ala Ala Arg 115 120 125 gct gcc aac gta gcc cgc gcc gcc gcc tcc aac cgg gcg gcc 431 Ala Ala Asn Val Ala Arg Ala Ala Ala Ser Asn Arg Ala Ala Arg Ala 130 135 140 gct gcc gcc gct gcc cgt acc gcc ttc agt cag gtg gtc gct agc cac 479 Ala Ala Ala Ala Ala Ala Arg Thr Ala Phe Ser Gln Val Val Ala Ser His 145 150 155 cgg gtg gcc acg ccg cag gtc tca gga gag gat acc cag ccc acg acc 527 Arg Val Ala Thr Pro Gln Val Ser Gly Glu Asp Thr Gln Pro Thr Thr 160 165 170 175 tac gcc gcc gag gct cag ggg ccc acc cct gag cca ccc ctt gct tct 575 Tyr Ala Ala Glu Ala Gln Gly Pro Thr Pro Glu Pro Pro Leu Ala Ser 180 185 190 ccg cag acc tcc cag atg tta gtc acc agt aag atg gct gcc ccc gag 623 Pro Gln Thr Ser Gln Met Leu Val Thr Ser Lys Met Ala Ala Pro Glu 195 200 205 gct ccg gca acc tcc gca cag tcc cag aca ggc tcc ccg gcc cag gag 671 Ala Pro Ala Thr Ser Ala Gln Ser Gln Thr Gly Ser Pro Ala Gln Glu 210 215 220 gct gct act gag ggc cct agt agc gcc tgt gct ttc tct cag gct ccg 719 Ala Ala Thr Glu Gly Pro Ser Ser Ala Cys Ala Phe Ser Gln Ala Pro 225 230 235 cgt gcc agg gag gtg gac gcc aac cgg ccc agc aca gcc ttc ctg ggc 767 Arg Ala Arg Glu Val Asp Ala Asn Arg Pro Ser Thr Ala Phe Leu Gly 240 245 250 255 cag aat gat gtc ttc gat ttc act cag ccg gca ggt gtc agt ggc atg 815 Gln Asn Asp Val Phe Asp Phe Gln Pro Ala Gly Val Ser Gly Met 260 265 270 gcc ttc ccg cgc ccc aag aga cct gcc cca gcc caa gag gct gcc aca 863 Ala Phe Pro Arg Pro Lys Arg Pro Ala Pro Ala Gln Glu Ala Ala Thr 275 280 280 285 gag ggc ccc agt gct gcc tct ggt gtg ccc cag acg gga cct ggc agg 911 Glu Gly Pro Ser Ala Ala Ser Gly Val Pro Gln Thr Gly Pro Gly Arg 290 295 300 gag gtg gca gcc acc cgg ccc aag acc acc aag tcg ggg aag gcg ctg 959 Glu Val Ala Ala Thr Arg Pro Lys Thr Thr Lys Ser Gly Lys Ala Leu 305 310 315 gcc aag act cgg tgg gtg gag cct cag aat gtt gtg gca gca gct gct 1007 Ala Lys Thr Arg Trp Val Glu Pro Gln Asn Val Val Ala Al a Ala Ala 320 325 330 335 gcc aag gcc aag atg gcc acg agc atc cct gag ccg gag ggt gca gct 1055 Ala Lys Ala Lys Met Ala Thr Ser Ile Pro Glu Pro Glu Gly Ala Ala 340 345 350 gct gcc act gct cag cac agt gct gag ccc tgg gcc agg atg gga ggc 1103 Ala Ala Thr Ala Gln His Ser Ala Glu Pro Trp Ala Arg Met Gly Gly 355 360 365 aag agg acc aag aag aag gtg aga tcc ccc tgc ccc ctg cca cct cca cac 1151 Lys Arg Thr Lys Lys Val Arg Ser Pro Cys Pro Leu Pro Pro Pro His 370 375 380 ccc ctt gct cct gtc ctt tcc ttc tcc tcc ctt tcc tgc tcc tct cct 1199 Pro Leu Ala Pro Val Leu Ser Phe Ser Ser Leu Ser Cys Ser Ser Pro 385 390 395 ccc tct cct ctc ccc ctt ctt cct ctc ttc tcc tct ttc ccc tcc ttc 1247 Pro Ser Pro Leu Pro Leu Leu Pro Leu Phe Ser Ser Phe Pro Ser Phe 400 405 410 415 tct cct cac ctc ccc tct cct ccc ctc ctc tcc tct cag cta gtc cat 1295 Ser Pro His Leu Pro Ser Pro Pro Leu Leu Ser Ser Gln Leu Val His 420 425 430 gtt tct cca aca caa gtt tgc tgagcatgtt ttcactccac gtagtcccta 1346 Val Ser Pro Thr Gln Val Cys 435 cc ctcaggac tggtgggaga agaggctggc tcagtgcctg gcacttagta agcacgcagc 1406 acatgccagc cgctgctggt actgctctca tttccaagag cctgctacgg gtgaggtgcg 1466 tgccgggtgc tttggcacgg ggagcctggt agccctgggt ctctcctctc tcaaatgata 1526 cagtccaagc acctggatga tgagtatgag agcagcgagg aggagagaga gactcccgcg 1586 gtcccaccca cctggagagc atcacagccc tcattgacgg tgcgggctca gttggcccct 1646 cggcccccga tggccccgag gtcccagata ccctcaaggc acgtactgtg cctgcccccc 1706 cgcaacgtga cccttctgca ggagagggca aataagttgg tgaaatacct gatgattaag 1766 gactacaaga agatccccat caagcgcgca gacatgctga aggatgtcat cagagaatat 1826 gatgaacatt tccctgagat cattgaacga gcaacgtaca ccctggaaaa ggtgggtgca 1886 ggatgggagc agctctgtgg gggaagagcg ggcatggggg tgcggtgacc ctgcagcccc 1946 tcaaggccca gtctctggag ccatctctca cctctccgac tctgagcttc cactgcactg 2006 gcagtttgac tcgtgcttcc tgccctcggc ttctctctct catgctctct gagtgtctcg 2066 ccgtctggcc aggtgggtct catcgcctct gccagcgtca gctcccacag cgaaggtctt 2126 ccgtgtgctg tcttcttctg ccctcgctca cgagtttgga ttccttgctg aggagcagtt 2186 ctaaccc gga atcactgtct gccggcagga tgcccagcat ggggtttgga tctcacactc 2246 tgttttctcc cccacgtaga agtttgggat ccacctgaag gagatcgaca aggaagaaca 2306 cctgtatatt cttgtctgca cacgggactc ctcagctcgc ctccttggaa agtaagaaag 2366 ggaaagcggg tcgtggcctt cctcggtggt gtcccttccc tgcccacacc ccttcagtga 2426 agcaggaaga cggggcttga gtgcggcgca ccgctcccac acacagcgag ggctgcctgg 2486 tgactgctgg atgaaaggaa tgatagcctg gggtgaggcc ttgctgccat cagttctccc 2546 caagctgctg ccgggcttta tccccaaagc ttcggaggaa agtgcctctt cctcctgcct 2606 gcctggcctg ggcctggcag agctggccta ggggagagct gcctcttcag tgtaggtgct 2666 gatgtggaag gggcaggaaa ggtctggagc catctctggg cacacgtttg ccatttgcag 2726 agcttcggct ccctgcctcg ccctgtcctc tgcagaaccc tgtcagggaa gtgttagtac 2786 ccatgtttta tagaggaggc gattaagtct caggcggagg tgcgaatggt ctgtcagcag 2846 ctagtgaact gtgcctgtcc tgggaagagt tcccctcaag ctgggaaacc tgagagaggc 2906 tagttgggag agcctggtgg tgtctctcag gcaaatagct gctaaacagg atttctcttt 2966 ccacaccttt agaaccaagg acactcccag gctgagtctc ctcttggtga ttctgggcgt 3026 catcttcatg aa tggcaacc gtgccagcga ggctgtcctc tgggaggcac tacgcaagat 3086 gggactgcgc cctgggtatg attggcctct ccagctcctc ccctcggtgc tatcctctgg 3146 ccaaagaggt cctgggattg caatagcctg gtggtctggc gcaagggcgt ggggtgccct 3206 gggctcggta gagagcaaag gatctcacca gggcggatgg ggaagcggtg ctggacgctg 3266 ctcagccctc tctctgctct gtggccccag atgacatcta agagagacag tcagagtcag 3326 ggattccatc aaatccctac ctggggcgtc cctgaccaac agtcctctgg cctctgctgc 3386 atgcccaggc ctccacagcg actccccggg ggctgggaag tcatagtcat gctagggagg 3446 gcccctgcca ccgtctctgc tcatggattc ctttccttgc cctcagggtg aggcacccat 3506 tcctcggcga tctgaggaag ctcatcacag atgactttgt gaagcagaag taagtatcac 3566 ctgagctaac tgcggctctc actcgagcat cctttgtgtg ctggtctggc tgagaaagca 3626 gttccctatc ccaaatcttc aactggaggg atgggtgcct ctgacctggg agtgagtggc 3686 agtggggggt atgcgagtgt gtggggagcc gaaggccagg gcggtcttgg gaaaagggag 3746 ctcacgtcac ctgagaacac ggtgtggggt gtgaaaacgg ccgccatcac cttgagcacc 3806 tgccctgtag actgacacaa gagttccccc tggtttacac ctaaggaacc cggagctcag 3866 agaggagacg cctctga gca tggctcccag ctggtaaggg cctcagccca actctcctga 3926 ttttcaggcc aggggccacc ctctccccgt ccctggagga cttgccaacg cacaggcgcg 3986 catgcacacc aacaaagggt caggacttga ggaggatgcc tggagcacgc ttctcctggc 4046 tgactgtttc ttcctctcca gtcgtttcct ctggtgggcc tctccagggc tccgccgggg 4106 tgtggccaag accctcgagg tggggtgtgc tcagagcagg gggcctgaag aatggctcct 4166 ctgtttacaa cacacccaac aggaagctgg ggtcatcgtg atgaggggca caaacttgtg 4226 gcctccctac agacaaatgc cctacatgtg gaccccctgc acctccgcat ggcttccggg 4286 gaggaccaat ggcaaaaggc tttgaaggcc tcacttttgc aggcagaagt cctgggagtg 4346 ggtttgggaa tgagtgaagg gctggagggg caggacagtc ctcttccagg agctgagctg 4406 cggcatcggg ttgaggaggg gccccctgga acccatccgt tcagcaacag gtctgcttgg 4466 ctagcagcaa agtttacttt cctctcatgc caaggtacct ggaatacaag aagatcccca 4526 acagcaaccc acctgagtat gaattcctct ggggcctgcg agcccgccat gagaccagca 4586 agatgagggt cctgagattc atcgcccaga atcagaaccg agacccccgg gaatggaagg 4646 ctcatttctt ggaggctgtg gatgatgctt tcaagacaat ggatgtggat atggccgagg 4706 aacatgccag ggcccagatg ag ggcccaga tgaatatcgg ggatgaagcg ctgattggac 4766 ggtggagctg ggatgacata caagtcgagc tcctgacctg ggatgaggac ggagattttg 4826 gcgatgcctg ggccaggatc ccctttgctt tctgggccag ataccatcag tacattctga 4886 atagcaaccg tgccaacagg agggccacgt ggagagctgg cgtcagcagt ggcaccaatg 4946 gaggggccag caccagcgtc ctagatggcc ccagcaccag ctccaccatc cggaccagaa 5006 atgctgccag agctggcgcc agcttcttct cctggatcca gcaccgttga cgaactgcag 5066 cgatcttact ggccaagcca gagcgcctcc tctcagattc cttctcgaca cagcacccta 5126 ggcggcttct tcctgtcagt cggaggtggc atgcaagatg aagctctctt tgctcttcct 5186 gctttcattt tgtgcttttc cttgtgtttt catgttttgg gtatcagtgt tacattaaag 5246 ttgcaaaatt 5256 <210> 60 <211> 4912 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (104) .. (313) <400> 60 ggtgttggtg ttgaggtgat ggtgatggtg ctgatggtag tgatgatggt ggtgatggtg 60 atggtggtga tgatgatggt ggtggtggtg gtgttggtgt tga ggt gat ggt gg gat gg gat ggt ggt ggt ggt ggt ggt ggt ggt ggt ggt ggt ggt ggt ggt ggt ggt Asp Gly Gly Gly Asp Gly Tyr Asp Asp 5 10 15 20 gat ggt ggt ggt ggt gtt ggt gtt gag gtg atg gtg atg gtg atg atg atg 211 Asp Gly Gly Gly Gly Gly Val Gly Val Glu Val Met Val Met Val Met Met 25 30 35 gat gat gac ggt ggt ggt ggt ggt gtt ggt gtt gag gtg atg gtg atg 259 Asp Asp Asp Gly Gly Gly Gly Gly Val Gly Val Glu Val Met Val Met 40 45 50 gtg gtg gtg ata gtg att atg atg ata gtg gtg gtg gtg gtg gt gtg 307 Val Val Val Ile Val Ile Met Met Ile Val Val Val Val Val Leu Val 55 60 65 ttg agg tgatggtgat ggtgctgatg gtagtgatga tggtagttgt gatgatggtg 363 Leu Arg 70 gtggtggtga tggtgatgat ggtggtagtc gtggtgatgg tgatggtggt gatggaggtg 423 gtggttcttg ggcacagtaa gggaggactg ggcctgccaa cacctgagct ccatcacctc 483 tcttacagcg tcaactccct ggacgacaac tctgtggatg tggacaag aa cagtcaggaa 543 atcaaggcaa gatgggggat gaattggtgc ctggaggttc caacttgggt tcttctgtgg 603 aggcttcagg gcagagctca agggacctgc tactgacatg ggcagttctg cttctctgca 663 ccaggcccca ggaagccctg tggctttgga atggggtcca attcctgctc ctccactggt 723 tcactgtgtg accctgagag acttcttgcc tctgcttctc agttttttca cctgtaaatg 783 gggatgggaa catcaaccat gcagggccat tgtgaggatt aaataagggc aggcataaga 843 accacttggc acaaacaagt gctcaccaat ctgcttccag ccctttatgg ccgttatagg 903 aaagccagct gggggtggga aagcagatcc agaggtgaac cagcatagtc tagcaaagga 963 gagaagatgg gttcaaataa acaacagtac cgccatctgt taaacaggtg agttggttgg 1023 atgagatcaa gtgttcatag actggcctgc tgcgtaaaag cacctgagga gctcttgaaa 1083 aatactgatg cccaggtcac acccaggtcc atgggtgcaa cattctagca ttttaaagac 1143 caagagttct gattctgatg gcccacgtgg agcctgggca tggacctgtt gtaaaagccg 1203 ctcagggggt gctaaggtgc aggcacggtg gacaccgctg gagcgggtca gcaggctgag 1263 tgtggggtgg gtcctggaca tggaggggtg gctctctgga aacagaagga actgccctct 1323 ctccttccca ctttgaaagc cacctctgga ggagacgctt aaggcccatt ggagctgtga 1383 taggctgagg ttctgtgtgt ggtgctgcgg gggatccacc cacattttcc cccagtctgg 1443 gttctgggct tggctgggtc ccaggccact aggggctccc aacctgactt catggttcag 1503 aatttgtttt ccctgaggac tccttacatg gaaagatttg gtcaaccgaa gcctctcttg 1563 gtctttaaaa tggtagaatg tcgcacaggg gcccaggtat aatacggtac agggaatctg 1623 gcacagaggc ctccggacag gccccaggta tggttgtgtg ggtggtaatg caggcagcca 1683 ggcagcgctg gaggcctctg ggtagatgct aggagatggt tagtggccaa aactctaatg 1743 aacatgtctg gggaactgag gcgaaggaac agtcttgtct actggagtgc atggcctgtg 1803 gcagaggctg atgctgctcc taacccaaag gagtggagtt aaggaccccc tgaggtgtgg 1863 ctggatctgt ggactgggaa ggggcaggga agtaggagaa gggtctggag agggtgtggg 1923 gacaagtcac ggaaagtctt caaagccaga aaattgctca gattatgtcc tgggagggca 1983 gggggttgct atatttctga gaagctgccc aaggctccac cctgtctcct gcagcagtga 2043 gtcttgcggg tctctgggca ggtccacgag gcatggggcc tttttgggag ctgtctgccc 2103 cctgctctcc catggctggg gtggcgcagg tggatccttt tcccaggaat ctcttggtgc 2163 cctgacttgt ctaagctcca cacgtctgtg tggtaggtgt gagtggctgg agagattatc 2223 actctaacct ccccaagtaa ccagcaagga aattcacatc cagagagggg tgctgacttg 2283 ctcaaagtgg gacagcttgc agggcagggg cagaccagaa cccaggtctt tggtctctgg 2343 caccaggtca tgttatcgtg ggtggcactg agcctgcagc tctccacttg gggtctgtct 2403 tgagggctct gaggaacaca ggcagaatgc ttagcccctc tggggcccct cggatgttcc 2463 actgtttact agggaccaga acagccccag tctggaaaaa gcccttggag tgccctgggg 2523 agggcggtgg tggccggggc tctggccctg tgggtgtctc tgtagcagag cagctgagct 2583 tgggggcctg gctgttccac aggagggtgt gtgtgtgtgt gcacgcacac agcatgtcgc 2643 atggcgaggt ggaagaggaa gggcgggaga gatgagtgag tgtgtgccat gataaactgc 2703 aggtgggacc agcctgtggg tagcgtccct ctgagggcag caaaaggaga cgtcaaattc 2763 aaccagggca gtgtcacatc atggacacgc ttttgaacca gcaagaccag tggtctgccc 2823 ctcttcacca gtagacctct ctaagcctca gtttccacat ctgtgaagag aggacatgtt 2883 ccctccctca gagggtttca gtgggtagtt gaggtaatgg atggacctca acccacacgg 2943 tgcctgccgt ggggtacagg gggcaggaac tgcgctgggc tggctcctcg gcacaggaca 3003 cagggcctgg cattatttgg aactgggctg aacggcagag tgccgcagtg ttggtgggca 3063 gggca aaggc aagagtggat cccccaggcc acaccctccc cctcccctaa tctgcatcac 3123 cattagccag ggccacctct gggacacagc ctggaccaga ggccccagga ggggcagggt 3183 gggacccctg ccaaggaacc actggtcgtg agcttgaagc ccatccactc ccctagggcc 3243 tggggcactc gccccacctt gccttgccct tcacacctcc tctccctctc cctgcaggag 3303 cacaggccac cacacacacc accagagcca gatccagagc ccctgagcgt ggtcctgtta 3363 ggacggcagg caggcgcaag tggacagctg gaggggccat cctacaccaa cgctggcctg 3423 gacaccacgg acctgtgaca ggggccccca ctcttctgga ccccttgaag aggccctacc 3483 acaccctaac tgcacctgtc tccctggaga tgaaaatata tgacgctgcc ctgcctcctg 3543 cttttggcca atcacggcag acaggggttg gggaaatatt ttattaccaa tgtatactgt 3603 gacagtttgt agccaaaaac tgcggctgga ggggtgggga cgggacactg agtggtcaca 3663 agggacttgg gctcacagca caggggggac aaggggctgg agagggtggc ctttaaaaga 3723 caactgtggt tatagaatga gctctctgtc ctgtccccaa tacccaagaa caccggtcac 3783 ccaggatgcc agggcccaag agcttctgtg agcccagctg tgacctccag accttcctga 3843 gaccctctgg cctttctgtg actctctctc agctgagccc ccagggtact tcctgtagct 3903 gtctttggcc tctctgggaa tctcaaacct gtgactcagt gggagagggg atggggctgg 3963 aaccaggcgg gtgggagata ggaactgggg aaggaccacc aacagcatgc aagagacgcc 4023 ccggccacgg ggccagccac tgcgtggaga cgctcacact cgttctacct cacgtgctgc 4083 ccgagacctc acattcagag acgtgcccac tcgcgggtct cacacaccga tcctcaccca 4143 cttgaagctt ctgccactca gacttgtatg cagtctctcc ctgttctggg gatctggccc 4203 caccggagac cacaacgcac cagtctagac atctcaggag cctgccccag ctctcagggg 4263 gtgggaggtg agggtgctga gcaggccccc gtggtcgccc agtgtgaccg ggagtagagc 4323 tgagggctgt gaggggacag tggggcgtca gggctggccg ggttcgtggc ctcgtggcca 4383 cgagggagct tggtagaagg ggttcttctg tatttgtgat gggaggggct ggaaagacgg 4443 ggacgcaaca gccctagagg ctgcacaacc cctcggaggc ctgtggcacg cagaggggac 4503 cccttctagg ggcctgtgat caagaaggga gcctgagaag gtcggaaact cgggcgtaca 4563 aaatgggggc agatcactcg gccgtgggtc ccgcccgcga gcagcaccgc ggccggcgca 4623 cactctgcag cagcgcgcgg aacaggccgg gcggacgctt ggcggcgcca tctgggggcg 4683 cggtgcgcac cgagcccgaa cggccggggc cggcacgggc ggcgggcggc ggcgcgggcg 4743 ccccttggcg gccgt gctcc tcgatctgtc gctccagatg cttctggatg gccatgccca 4803 gcacctccac ctccatggcg gcgccgtata cctcccacgt catgcccttc tcgtcccagc 4863 tcacgtctcg cacgggctca gccggctccg ggggcgcc ag <210> 61 <211> 5686 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (645) .. (2321) <400> 61 ggcctgcaga gagccggcac tatctctact gctgctgctg ctgctactgc tgctgttgct 60 accgctgcct ctgctgccac cgccactact gctgccagcg gagccgctag gagtgagcat 120 cccctctccg ggatacccag ctccgcggcg tctcccgcgc gccctggccc cacacggacc 180 tgccagcccc agggaacaaa agcggagccc gctcgccctc tactgcagcc ggaggatgag 240 tcgagagggc tgagcggaga gtgtggtcct cggcggctgg agctatttcc ttggcttctc 300 tccatgacga ttcctgactc gtggccccgg caatcttggg aagacatcat ccagcttctt 360 cagtccagac cctgggcacc ccccttttgc caggatcgtc cccacccagc ctggacacat 420 tgactgaact gttttctagg acactgcact cagcaagaca tggtggtgag ccctgactct 480 cagtcttcat gattgaagaa ctcttttgta caacacaaag cactcaaaaa gagtgaatga 540 aatgtgcagc tcagagtgtc atttctgaag ggaggagtct ttctcttgga gaagagtcct 600 caatgagcct ggccgaggcc cgggatctgt gtgaagtgga ctaa gga tta agt agg 656 Gly Leu Ser Arg 1 atg tca act gag aca gaa ctt caa gta gct gtg aaa acc agc gcc aag 704 Met Ser Thr Glu Thr Glu Leu Gln Val Ala Val Lys Thr Ser Ala Lys 5 10 15 20 aaa gac tcc aga aag aaa ggt cag gat cgc agt gaa gcc act ttg at a 752 Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Thr Leu Ile 25 30 35 aag agg ttt aaa ggt gaa ggg gtc cgg tac aaa gcc aaa ttg atc ggg 800 Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 40 45 50 att gat gaa gtt tcc gca gct cgg gga gac aag tta tgt caa gat tcc 848 Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 55 60 65 atg atg aaa ctc aag ggc gtt gtt gct ggc gct cgt tcc aaa gga gaa 896 Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 70 75 80 cac aaa cag aaa atc ttt tta acc atc tcc ttt gga gga atc aaa atc 944 His Lys Gln Lys Ile Phe Leu Thr Ile Ser Phe Gly Gly Ile Lys Ile 85 90 95 100 ttt gat gag aag aca ggg gcc ctt cag cat cat cat gct gtt cat gaa 992 Phe Asp Glu Lys Thr Gly Ala Leu Gln His His His Ala Val His Glu 105 110 115 ata tcc tac att gca aag gac att aca gat cac cgg gcc ttt gga tat 1040 Ile Ser Tyr Ile Ala Lys Asp Ile Thr Asp His Arg Ala Phe Gly Tyr 120 125 130 gtt tgt ggg aag gaa ggg aat cac aga ttt gtg gcc ata aaa aca gcc 1088 Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Thr Ala 135 140 145 cag gcg gct gaa cct gtt att ctg gac ttg aga gat ctc ttt caa ctc 1136 Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Le Phe Gln Leu 150 155 160 att tat gaa ttg aag caa aga gaa gaa tta gaa aaa aag gca caa aag 1184 Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 165 170 175 180 gat aag cag tgta gtg tac cag aca ata ttg gaa gag gat 1232 Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Thr Ile Leu Glu Glu Asp 185 190 195 gtt gaa gat cct gtg tac cag tac att gtg ttt gag gct gga cac Asag 1280 Val Val Tyr Gln Tyr Ile Val Phe Glu Ala Gly His Glu 200 205 210 cca atc cgt gat ccc gaa acg gaa gaa aac att tat cag gtt ccc acc 1328 Pro Ile Arg Asp Pro Glu Thr Glu Glu Asn Ile Tyr Gln Val Pro Thr 215 220 225 agc caa aag aag gaa ggt gtt tat gat gtg cca aaa agt caa cct gta 1376 Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val 230 235 240 agt gct gtg acc caa tta gaa ctt ttt ggg gac atg tcc aca ccc cct 1424 Ser Ala Val Thr Gln Leu Glu Leu Phe Gly Asp Met Ser Thr Pro Pro 245 250 255 260 gat ata acc tct ccc ccc act cct gca act cca ggt gat gcc ttt atc 1472 Asp Ile Thr Ser Pro Pro Thr Pro Ala Thr Pro Gly Asp Ala Phe Ile 265 270 275 cca tct tca tct cag acc ctt cca gcg agt gca gat gtg ttt agt tct 1520 Pro Ser Ser Ser Gln Thr Leu Pro Ala Ser Ala Asp Val Phe Ser Ser 280 285 290 290 gta cct ttc ggc act gct gct gta ccc tca ggt tac gtt gca atg ggc 1568 Val Pro Phe Gly Thr Ala Ala Val Pro Ser Gly Tyr Val Ala Met Gly 295 300 305 gct gtc ctc ccg tcc ttc tgg ggt cag cag ccc ctc gtc cag 1616 Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln Gln 310 315 320 atg gtc atg ggt gcc cag cca cca gtc gct cag gtg atg ccg ggg gct 1664 Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly Ala 325 330 335 340 cag ccc atc gca tgg ggc cag ccg ggt ctc ttt cct gcc act cag cag 1712 Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Thr Gln Gln 345 350 355 ccc tgg cca act gtg g cc ggg cag ttt ccg cca gcc gcc ttc atg ccc 1760 Pro Trp Pro Thr Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met Pro 360 365 370 aca caa act gtt atg cct ttg cca gct gcc atg ttc caa ggt ccc ctc 1808 Thr Gln Thr Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro Leu 375 380 385 acc ccc ctt gcc acc gtc cca ggc acg agt gac tcc acc agg tca agt 1856 Thr Pro Leu Ala Thr Val Pro Gly Thr Ser Asp Ser Thr Arg Ser Ser 390 395 400 cca cag acc gac aag ccc agg cag aaa atg ggc aaa gaa acg ttt aag 1904 Pro Gln Thr Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Thr Phe Lys 405 410 415 420 gat ttc cag atg gcc cag cct ccg ccc gtg ccc tcc cgc aaa ccc gac 1952 Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro Asp 425 430 435 cag ccc tcc ctc acc tgt acc tca gag gcc ttc tcc agt tac ttc aac 2000 Gln Pro Ser Leu Thr Cys Thr Ser Glu Ala Phe Ser Ser Tyr Phe Asn 440 445 450 aaa gtc ggg gtg gca cag gat aca gac gac tgt gat gac ttt gac atc 2048 Lys Val Gly Val Ala Gln Asp Thr Asp Asp Cys Asp Asp Phe Asp Ile 455 460 465 tc c cag ttg aat ttg acc cct gtg act tct acc aca cca tcg acc aac 2096 Ser Gln Leu Asn Leu Thr Pro Val Thr Ser Thr Thr Pro Ser Thr Asn 470 475 480 tca cct cca acc cca gcc cct aga cag agc tct cca tcc aaa tca tct 2144 Ser Pro Pro Thr Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser Ser 485 490 495 500 gca tcc cat gcc agt gat cct acc aca gat gac atc ttt gaa gag ggc 2192 Ala Ser His Ala Ser Asp Pro Thr Thr Asp Asp Ile Phe Glu Glu Gly 505 510 515 ttt gaa agt ccc agc aaa agc gaa gag caa gaa gct cct gat gga tca 2240 Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly Ser 520 525 530 cag gcc tca tcc agt gat cca ttt ggt gag ccc agt ggg gag ccc 2288 Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Glu Pro Ser Gly Glu Pro 535 540 545 agt ggt gat aat ata agt cca cag gcc ggt agc tagatagcgc aggtctggga 2341 Ser Gly Asp Ser Pro Gln Ala Gly Ser 550 555 gccagagcct ctgtacgcgc agatcaacag acctaagaaa tagcatcgat gcgagctcgt 2401 ggtgggtgct caagactggc atggacatca gcatcacgac aggctctctt gtattctttc 2461 acctctt ccc acaagaaatt catgattgcc caatggaact cgctcagaag agggaactaa 2521 gcatttttgg caaccaatgg cagatatcta tggcagcaca caaaaaaagt atagaaagat 2581 ccacccaaca ttaaatcaga aatcaagcaa atgcttaccc aacaaatatt tgagccctca 2641 tagctgggtt taagatgact cagtgtgcaa aattattaat tcccttttta tttctctacc 2701 tgttgaccac tgttgagaca ccaaatttgg agtgacaggc atcagaggat tacaacaggg 2761 ttggaactga cttctttaag caaaagcaaa gggtcttctg tgaccacaat atcgtcatcc 2821 atatgccttt tcacatagga tgatgtgttt tttgtcactc catggggcct ggtctgccat 2881 tttcccccct ttcctttttt tgtcatgttt gaaaattaat aggtgtacaa atttttgtat 2941 tgcttttgac tttttttaga tatgggtgaa gaaatctaac tggggagaaa aaaagcctca 3001 gtgaaatgaa ttaacttgaa attacaagac aaataagtgg ttgattattc attatgatca 3061 cgaatgttgc caaaacagtc ctttagctat tctgcatcct ggtgaagaaa gacagctttc 3121 agtacgaacc ttcattctgt gagtaggaaa agacatcaga tcccattgat gagaaagatg 3181 aaaaatgcat ctgatttctt aagaagctct aaactctaag tacaataaaa tgatattttt 3241 tatttttccg atatcttgct gctgtgttgc tatgcagaca agtgtcttct ccacgtgcca 3301 ttttcaaaga aa agtcattt gccaaataat tctggtacaa ttctggtaat gtggttttgg 3361 atcttaaaaa ccaactttct aatggaacaa tggtggcata aatattcaga ataacaaact 3421 gattctgtgg tccaaatggt tcatctctat ctctttttgt acatcagaaa attcaaatgg 3481 gatttttatt ttataacttg aaaaaaaaac cttaccatta aactctttaa atatttaagg 3541 gaaatggctt taaggagttc taatgaaaaa aaattgtctt ttttttgtaa atataaatgt 3601 taatgaaaat gatttttaat aatgccatta cactgtagag aaggtagcag attgagtgca 3661 aggtgtgaca aacttgatgg atggggctca ctttccagac gttattctgg agcatatggt 3721 aggaagctgg agtgcaggga cagctggcag gagcagttgg ccaatcagca gctagtgaac 3781 gggaagggag cacgtgactc catcatctag cctttccacg agagtcccca ccctacgtgc 3841 aacacaagaa aaagacaatt cacattctga agaattcaga ttctgaaact ctcccacctc 3901 cccactccca cctacccccg atataaatca ctggactgtt tgtacgtgaa acagaagagg 3961 ctaagcttcc tttttttaca cttatgagac aaaaagtgca gtgtttggtt cgtatgttta 4021 gcacatgatt ttcataaaga atctatatat ttttgcccta cagagaattg ttatacaggt 4081 caagtgtgtt ttcctgatgt tcctatgcag ttacagtatg ttgaaagtgt tttaacacta 4141 agaagaaaac tttaaag att catgtgatta attggatttg aggataatta ttattatttg 4201 gtttttagat ttgaaaagta gaatttccat tgagacaatt gatttgaata ggcctgcatt 4261 tgattcttca tatcaataga aactaaaatg atttgggaga ttcatttgaa aaatgattgt 4321 atacttgttc acaaagcgaa aagtgataca tgaaggtaat ggttatcatt taaagcccac 4381 attttacact atcaggtcac aggagtctaa tttttttttc agttagataa actgaccaaa 4441 cgtctattca agaatatatg tcaatatcat cctaatgtgg aaggtccgaa gaaccagaaa 4501 agtgagaagg gccgtttacc tccctctgta gctatcacct gttggtccac agagtttctt 4561 gagaaatgag caaacatttt atgattaggt aaccctttca catgaacggg aagatgggaa 4621 aggtggaatg accataagag ttggcctgag accagtttgt tttctgggga tttggtaaga 4681 taggcagttc ccatgggaaa ttgcttaaat tgctttgttg cctatgattt gattctaaac 4741 aagtggtgct atcttctccc tcaatatggc tgtcttgagt ttgtcttgca gtatcacacc 4801 attataccaa ttctttgggt tgcttctgac acattcaaag tgaactctgg ctgatgttgc 4861 tgtttcaggt ataccatctg gagttaattt cctagcagaa ggtgaaagtc caggagaatt 4921 gtcctctttc attgaacatg attgaaaatg taactggctc tgaacttcaa gaagatagat 4981 gcccaagtga tgcattaaag t aagggaaat aaagtcaagt ttttcaactg ccatccatat 5041 tctcattggc agaattctga tttttttcca agcactgttt ggtgagcctg gaagcaccgt 5101 atcctgtccc aggagtacag tgaaatttcc aagcaagagc tgaggtgcca ataccaaaag 5161 accatgggga gtctgcacgg ttctggttag atcaatagaa aatccatgtg tacaactgtt 5221 aattcctcat cctccactag cactaaattt gtcactttaa attttgaaac cagggaaaca 5281 ccacctgtca ttctgtcccc attctccata gctcttcaat ctttacatgc cgcaagactt 5341 ttttgatagc tcgtactcat cccagtgtct cctgaaaccc catcatgtaa tgtactgggc 5401 accttctttt aaacaaatgt ttactctgtg ggtttggttc atttcaattt ctgcgttctg 5461 acacatattt ttttaataaa gatgagaaag agaaaatgac tgttgcagta cctttctaga 5521 cctactttaa ctttacctca gatgacagtt tgttaacata tatggacaca ttatttttaa 5581 ctttatgtac aatgcattca acagaacagc aaaattttta gaaattttcc attaatttct 5641 gtaacacacc atgtaaaact gttacaaata aacatgtttg agaac 5686 <210> 62 <211> 4843 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1729) <400> 62 c agg gag ttc aag cta gac aag aag tac cag agg cca cag gac agt gaa 49 Arg Glu Phe Lys Leu Asp Lys Lys Tyr Gln Arg Pro Gln Asp Ser Glu 1 5 10 15 gat atg tgg ggt gac gag gac ttc acc ttt gga gcc tat cag ccc act 97 Asp Met Trp Gly Asp Glu Asp Phe Thr Phe Gly Ala Tyr Gln Pro Thr 20 25 30 gtg gtc tcc tct gag ggc cgg cag tcc cgc cgg cag tct gtc agg ttc 145 Val Val Ser Ser Glu Gly Arg Gln Ser Arg Arg Gln Ser Val Arg Phe 35 40 45 ttc gca gac agt ggc gca gac ccc aag gga gaa cca ggc tcc aaa cag 193 Phe Ala Asp Ser Gly Ala Asp Pro Lys Gly Glu Pro Gly Ser Lys Gln 50 55 60 agc cct cca atg gct tcc agc ccc atc cag ccc agg aag gga gga gct 241 Ser Pro Pro Met Ala Ser Ser Pro Ile Gln Pro Arg Lys Gly Gly Ala 65 70 75 80 gac tgg ttg ggc ctc aag gac gag gac ttg gac ctg ttc cct gcc tca 289 Asp Trp Leu Gly Leu Lys Asp Glu Asp Leu Asp Leu Phe Pro Ala Ser 85 90 95 ccc acc aga gag gcc cat cgg gaa agt tca gtg cct gtc acg ccc tca 337 Pro Thr Arg Glu Ala His Arg Glu Ser Ser Val Pro Val Thr Pro Ser 100 105 110 gtg cct cct cct gcg agc cag cac tcc acg cca gct ggg ctg ccc ccc 385 Val Pro Pro Pro Ala Ser Gln His Ser Thr Pro Ala Gly Leu Pro Pro 115 120 125 tcc agg gca aag cca cca act gaa ggt gca ggg tcc cct gcc aaa gcc 433 Ser Arg Ala Lys Pro Pro Thr Glu Gly Ala Gly Ser Pro Ala Lys Ala 130 135 140 agc cag gct tcc aag ctg cga gcc tcc aag gag gag aaa gag gac tgg 481 Ser Gln Ala Ser Lys Leu Arg Ala Ser Lys Glu Glu Lys Glu Asp Trp 145 150 155 160 ctg agc cat gcc ctg tct cgg aag aag tcc caa ggc ctg gcc aga gag 529 Leu Ser His Ala Leu Ser Arg Lys Lys Ser Gln Gly Leu Ala Arg Glu 165 170 175 cag cat gct ggg acc tct gag ggc ctg cat ttg gcg ggg aca gcg ggc 577 Gln His Ala Gly Thr Ser Glu Gly Leu His Leu Ala Gly Thr Ala Gly 180 185 190 cat ccc cct tct ggc agc caa cct ctc acc agc aca caa ggg ctt gag 625 Pro Pro Ser Gly Ser Gln Pro Leu Thr Ser Thr Gln Gly Leu Glu 195 200 205 cac gca gct gct gga ggg agt tct gga aca act gca cga gaa aga ccg 673 His Ala Ala Ala Gly Gly Ser Ser Gly Thr Thr Ala Arg Glu ArgPro 210 215 220 tgt gtc agg cct ggt gtc tcg ggg tcc cct gtg act cag aac cat gcc 721 Cys Val Arg Pro Gly Val Ser Gly Ser Pro Val Thr Gln Asn His Ala 225 230 235 240 gcc tca gca ctc cct aca ggt tcc cca aag agg gga aca gcc cct gga 769 Ala Ser Ala Leu Pro Thr Gly Ser Pro Lys Arg Gly Thr Ala Pro Gly 245 250 255 gac ctc tca gcc act gag cct gcc acg tgt ttc ccg agc acc cag aaa 817 Asp Leu Ser Ala Thr Glu Pro Ala Thr Cys Phe Pro Ser Thr Gln Lys 260 265 270 ccc aca gag cct tcc gtg ccc gtc cag ccc ctg ctc cca gag tcc ctg 865 Pro Thr Glu Pro Ser Val Pro Val Gln Pro Leu Leu Pro Glu Ser Leu 275 280 280 285 gcc cgg agc ctg ctg ccg agc aca gaa tac cag aag cag ctc ctg gca 913 Ala Arg Ser Leu Leu Pro Ser Thr Glu Tyr Gln Lys Gln Leu Leu Ala 290 295 300 gca cag gtg caa ctt cag tgc agc ccc gg gag gcc ctg 961 Ala Gln Val Gln Leu Gln Cys Ser Pro Ala Glu Leu Gln Ala Glu Leu 305 310 315 320 ctg cat agc cag gcc cgg ctg gca gag ctg gag gcc cag gtg cgg aag 1009 Leu His Ser Gln Ala Arg Leu Ala Glu Le Glu Ala Gln Val Arg Lys 325 330 335 ctg gag cta gaa cgg gcc cag cat gag ctg ctg ctg ggg agt ctg cag 1057 Leu Glu Leu Glu Arg Ala Gln His Glu Leu Leu Leu Gly Ser Leu Gln 340 345 350 cag cag cac cagca ctg gag ctc atc gag agt gca cac aga agc 1105 Gln Gln His Gln Ala Asp Leu Glu Leu Ile Glu Ser Ala His Arg Ser 355 360 365 cgc atc aag gtg cta gaa aca tcg tac cag caa cgg gag gag cgg ctc 1153 Ar Val Leu Glu Thr Ser Tyr Gln Gln Arg Glu Glu Arg Leu 370 375 380 cgg aga gag aac gaa gag ctg tca gct cgg tat ctg tcg cag tgc cag 1201 Arg Arg Glu Asn Glu Glu Leu Ser Ala Arg Tyr Leu Ser Gln Cy Gn 390 395 400 gaa gcc gaa cag gcc cgt gct gag ctt acg gcc cag cac cag cgg cgc 1249 Glu Ala Glu Gln Ala Arg Ala Glu Leu Thr Ala Gln His Gln Arg Arg 405 410 415 ttg gcg gcc ata gcag cag gag agac atg gag cgg ctc cgg 1297 Leu Ala Ala Ile Ala Gln Glu Lys Asp Gln Glu Met Glu Arg Leu Arg 420 425 430 gag ctg cag cgg gcg tcc atc cta gac atg cgc aga gac cac gag gag 1345 Glu Leu Gln Arg Ser Ile Leu Asp Met Arg Arg Asp His Glu Glu 435 440 445 cag ctg cag cgg cta aag ctg ctg aag gac cga gag gtc gat gcg gcc 1393 Gln Leu Gln Arg Leu Lys Leu Leu Lys Asp Arg Glu Val Asp Ala Ala 450 agt gcc acc tcc cac acg cgg tcc ctg aat agc atc atc cac cag 1441 Thr Ser Ala Thr Ser His Thr Arg Ser Leu Asn Ser Ile Ile His Gln 465 470 475 480 atg gag aag ttc tcc agc agc ctg cac gag ttg tcc cccg gtg gag 1489 Met Glu Lys Phe Ser Ser Ser Leu His Glu Leu Ser Ser Arg Val Glu 485 490 495 gcc tcg cac ctc acc acc tcc cag gag cgg gag ctg ggg atc cgg cag 1537 Ala Ser His Leu Thr Thr Ser Gln Glu Arg Glu Leu Gly Ile Arg Gln 500 505 510 cgt gac gag cag ctg cgg ggt acg ccc tcc cct ctc agc cac ccc ggc 1585 Arg Asp Glu Gln Leu Arg Gly Thr Pro Ser Pro Leu Ser His Pro Gly 515 520 525 tcc tgg tgg tgg gaa ggg gag cag ctg ctg agc acc ctg tgg gtt gcc ccc 1633 Ser Trp Trp Glu Gly Glu Gln Leu Leu Ser Thr Leu Trp Val Ala Pro 530 535 540 agc act gca gga gcg gct ggg cca gca gca gcg gga cat gga gga gga 1681 Ser Thr Ala Gly Ala Ala Gly Pro Ala Ala Ala Gly His Gly Gly Gly 545 550 555 560 gcg gag ccg gca aca gga ggt cat cgg gaa gat gga ggc acg gct gaa 1729 Ala Glu Pro Ala Thr Gly Gly His Arg Glu Asp Gly G Thr Ala Glu 565 570 575 tgagcagagc cggctgctgg agcaggaacg ctggcgggtg actgccgagc agtccaaggc 1789 ggagtccatg cagcgcgccc tagaggagca aaggaaggtc acggcccagc agatggccat 1849 ggaaagggcg gagctggaac gggccaagag cgccttgctg gaggagcaga agtctgtcat 1909 gctcaagtgc ggggaggagc ggcggcgcct ggctgccgag tgggcggagt tctccgcgca 1969 gcaaaagctg agagcaggct gagctgaaga tcagggccag cgagctccgg gccgaggaga 2029 agcagctggc agcggagaga gcagccctgg agcaggagcg gcaggagctg cggctggaga 2089 aggagaggat caacgccacc gccctgcgtg tcaagctccg cgccgaggag gtggagagca 2149 tgagcaaggt ggcctccgag aagtacgagg agggggagcg ggcattgcgc gaggcccagc 2209 aggtgcaggc agagcagcag gcccggttgc aggcggtgca gcaacagcag gagcggctgc 2269 ggaagcagga gcagcacatg caccaggagc atctgagtct ggcccagcag aggctgcaac 2329 tggaccgcgc acgacaggac ctgccctcta gcctcgtggg tctgttcccc agggcccagg 23 89 gccctgcagc ctccagccag agtgccctca tgcctcctgc tcccaccacc cgttggtgca 2449 gccagccgcc aactggcctg gaccccagcc ccttgcacct ccatgccagg ctggcactgc 2509 tgaggcacat ggcagagcag gaccgtgact tcttggagaa tgaacagttc ttcctggaga 2569 ccctgaagaa agggtcctac aatttgacat ctcattcagc ctgagtggga ccccagccga 2629 ttccccaaca gagggttcgg accccagaac tgtcctgttc ctccggctgc ctccatggag 2689 gcagtgcctg gggaggattc tgagatgctt gaggcctgat gacagctctt ccgtggacag 2749 ggtgcaagtg catcctttcc aaatgtgcca gcccggggca gcccctgcct ctggggctct 2809 gtggtgtagg ctatcttacc atggctttgg ctgccctgcc ccaaagccat tggcttggat 2869 ctgagggtct gagttggcag caaggacccc cagctctcac tgggctctgt gggctccccc 2929 tgggctctgt gggctccccc tgctccacag gtagactgtt gtgggctctt tttgcctggg 2989 cctcttctga ggcaggagct ttcttgaggg atgccacaaa cagccttccc tactccctgc 3049 cagagcagtt ccctccctga tgagctggag aagggccctc tggcctcctg acagtacagg 3109 gagggcacca gctagatcct cccttgtggt gtgagatgtt cctggaactc agccaggccc 3169 tcctcctcct gggcttgccc agagccccca ccctattccc agcattgccc gaaggaccaa 3229 cca gtttggg tgaacagtgg cctcctcagc ttcctcccca tctgggtgcc ccaccggcgg 3289 cggagggagc tgtggcgatg gtggggtgtg gggagggacg aggagggaag cctctgtgct 3349 gctcacctgc ccaaagccca gctcagcggg tacgcagtgg aggcgacaag gaaccaatca 3409 caactacaga ggtttctctg atcctcctcc actcccgctg cttcaacttg actaagctta 3469 aaaaaactgc ttttgccatg gctcatcgga gtttatactt atttcttaga aaatgtttcc 3529 tgttatttgc tggacaagtc ccaaagaaca ggcagatgtt cttattaaaa gatcagccta 3589 taagattggt caggaccagg cgcctctggc cacgtgcctc tcccctccag cacctgcggt 3649 ctgcggtggc acctggcagc tggaccacag ccaggagaag ggtactatta gccctgcttc 3709 aaacatgcag aaactgaggc ccggggagat taaataacct gcctgaaatg acagtgagta 3769 gctgcgcctg gatttgagtt ctgctctggc caatccccaa gctccacgct gtcagccacc 3829 ccgctctcct acctcccaga ggagcaggct acactcctgc cgtcctgggc cgccggacac 3889 ccccgctggg gccgatgccc aacagtgaca tcgacttgag caacctggag cggctggaga 3949 agtaccggag cttcgaccgc taccggcgcc gagcagagca ggaggcgcag gccccgcact 4009 ggtggcggac ctaccgagag tatttcgggg agaagacaga tcccaaagag aagattgata 4069 ttgggctg cc tccacccaaa gtctcccgga cccaacagct actggaacgg aaacaggcca 4129 tccaggagct tcgggccaat gtggaagagg agcgggctgc ccgcctccgc acagccagtg 4189 tcccgctgga tgccgtgcgg gccgagtggg agaggacctg tggcccctac cacaagcagc 4249 gtctggctga gtattacggc ctctaccgag acctgttcca cggtgccacc tttgtgcccc 4309 gagtccccct gcacgtggcc tacgctgtgg gtgaggatga cctgatgcct gtgtactgtg 4369 gcaatgaggt gactccaacc gaggctgccc aagcgccaga ggtgacctat gaggcagaag 4429 agggctcctt gtggacgttg ctactcacta gcttggatgg gcacctgctg gagccagatg 4489 ctgagtacct ccactggctg ctaaccaaca tcccgggtaa ccgggtggct gaaggacagg 4549 tgacgtgtcc ctacctcccc cccttccctg cccgaggctc cggcatccac cgtcttgcct 4609 tcctgctctt caagcaggac cagccgattg acttctctga ggacgcacgc ccctcaccct 4669 gctatcagct ggcccagcgg accttccgca cttttgattt ctacaagaaa caccaagaaa 4729 ccatgactcc agccggcttg tccttcttcc agtgccgctg ggatgactcc gtcacctaca 4789 tcttccacca gcttctggac atgcgggagc cggtgtttga gttcgtgcgg ccgc 4843 <210> 63 <211> 5605 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (4217) <400> 63 gg gca aag cgg agc ctc aag aag gtg gcc tac aat gct ctt ttc aca 47 Ala Lys Arg Ser Leu Lys Lys Val Ala Tyr Asn Ala Leu Phe Thr 1 5 10 15 aat ctt ttt caa gat gag act caa cag ctg cag cct gac atg tca aaa 95 Asn Leu Phe Gln Asp Glu Thr Gln Gln Leu Gln Pro Asp Met Ser Lys 20 25 30 cta cca gcg aga aac aag atc ctc atg ttg tcc ttt gac ttg aga gtg 143 Leu Pro Ala Arg Asn Lys Leu Met Leu Ser Phe Asp Leu Arg Val 35 40 45 ggt ggc ctg ggc ccc aag gcc gac cgt ttg gag gag ctt gtg gag gag 191 Gly Gly Leu Gly Pro Lys Ala Asp Arg Leu Glu Glu Leu Val Glu Glu 50 55 60 ctg gaa gca gcc cct tgc tgt ccg ctt ttg gag gtg ggg tct gtt ttg 239 Leu Glu Ala Ala Pro Cys Cys Pro Leu Leu Glu Val Gly Ser Val Leu 65 70 75 gac ctc ctg gtt cag ctg gca ggg agt ggt ccc cct caagtt 287 Asp Leu Leu Val Gln Leu Ala Gly Ser Gly Pro Pro Gln Val Leu Pro 80 85 90 95 aga aaa cga gac tac ttc ctt aac aac aag cat gtg ggg aga aac gtt 335 Arg Lys Arg Asp Tyr Phe Leu Asn Asn Lys His Val Gly Arg Asn Val 100 105 110 ccg tac agc ggc tat gat tgc gac gac ctg agt gtg ttt gag atg gac 383 Pro Tyr Ser Gly Tyr Asp Cys Asp Asp Leu Ser Val Phe Glu Met Asp 115 120 125 gtt cag tct ctg atc tcc aga gaa gag tgt attg tgtc atc 431 Val Gln Ser Leu Ile Ser Arg Glu Glu Cys Leu Cys His Ser Met Ile 130 135 140 cag gaa aca ctt cag gtt atg gag gct gct cca ggc act ggc ctg ccc 479 Gln Glu Thr Leu Gln Val Met Glu Ala Ala Pro Gly Thr Gly Leu Pro 145 150 155 acc gtc ggg ctc ttc tca ttt ggt gac cct tgt ggt gac agg ttc gag 527 Thr Val Gly Leu Phe Ser Phe Gly Asp Pro Cys Gly Asp Arg Phe Glu 160 165 170 175 aga gac acc cgg gtc tcg ctc ttc ggg gcc ctt gtg cac agc cgc act 575 Arg Asp Thr Arg Val Ser Leu Phe Gly Ala Leu Val His Ser Arg Thr 180 185 190 tat gac atg gac gtc cga ctg ggc ctg ccc ccc gtg cca gac aat gcg Tyr Asp Val Arg Leu Gly Leu Pro Pro Val Pro Asp Asn Ala 195 200 205 gac ctc tct ggg ctg gct att aag gtc cca ccg agt gtg gat cag tgg 671 Asp Leu Ser Gly Leu Ala Ile Lys Val Pro Pro Ser Val Asp Gln Trp 210 215 220 gaa gac gaa gga ttc cag tca gcg tcc aac ttg act cct gat tcc cag 719 Glu Asp Glu Gly Phe Gln Ser Ala Ser Asn Leu Thr Pro Asp Ser Gln 225 230 235 tct gag ccc agc gtg acc cca gac gtg gacct gaa gcc gca ctt 767 Ser Glu Pro Ser Val Thr Pro Asp Val Asp Leu Trp Glu Ala Ala Leu 240 245 250 255 acc tat gag gcc agc aag cgg agg tgc tgg gag cga gtt ggc tgc ccc 815 Thr Tyr Glu Ala Ser Lys Arg Arg Cys Trp Glu Arg Val Gly Cys Pro 260 265 270 cct ggc cac aga gag gag cct tac ctg acg gag gcg gga agg gac gct 863 Pro Gly His Arg Glu Glu Pro Tyr Leu Thr Glu Ala Gly Arg Asp Ala 275 280 280 285 ttc gacag ttc tgc agg ctc cac caa ggg gag ctc cag ctg ctt gct 911 Phe Asp Lys Phe Cys Arg Leu His Gln Gly Glu Leu Gln Leu Leu Ala 290 295 300 ggg ggc gtc cta cag gcc ccg cag ccc gtg agg tg Gly Gly Val Leu Gln Ala Pro Gln Pro Val Leu Val Lys Glu Cys Glu 305 310 315 ctg gtg aaa gac gtg ctg aac gtc ttg att ggg gtc gtg tct gcc acg 1007 Leu Val Lys Asp Val Leu Asn Val Leu Ile Gly Val Val Se r Ala Thr 320 325 330 335 ttt tcg ctc tgc cag ccg gcc cag gcc ttt gtg gtg aag cgg ggc gtc 1055 Phe Ser Leu Cys Gln Pro Ala Gln Ala Phe Val Val Lys Arg Gly Val 340 345 345 350 cac gtg tca gcc gct gag agc atc agc agc ctg ctc tcg gaa 1103 His Val Ser Gly Ala Ser Pro Glu Ser Ile Ser Ser Leu Leu Ser Glu 355 360 365 gtg gcc gag tat ggg acc tgc tac acg cgc ctg agt cat ttc tct ctg 1151 Val Ala Glu Gly Thr Cys Tyr Thr Arg Leu Ser His Phe Ser Leu 370 375 380 cag ccc gtc ctg gac tct ttg tac agc aag ggc ctc gtg ttc cag gcc 1199 Gln Pro Val Leu Asp Ser Leu Tyr Ser Lys Gly Leu Val Phe Gln Ala 385 390 395 ttc acc agt ggc ctg agg agg tac ctg cag tat tac cgg gcc tgc gtc 1247 Phe Thr Ser Gly Leu Arg Arg Tyr Leu Gln Tyr Tyr Arg Ala Cys Val 400 405 410 415 ctt tcc act ccg ccc acc ctg agc acct ctc ctc ggt ttt ctc ttc 1295 Leu Ser Thr Pro Pro Thr Leu Ser Leu Leu Thr Ile Gly Phe Leu Phe 420 425 430 aag aaa ctt ggc cgg cag ctc agg tac ctg gcc gag ctc tgt ggc gtt 1343 Lys Lys Leu Gly Arg Gln Leu Ar g Tyr Leu Ala Glu Leu Cys Gly Val 435 440 445 ggc gct gtg ctc ccg ggc acc tgt gga gga ggc ccc agg gcc gcg ttt 1391 Gly Ala Val Leu Pro Gly Thr Cys Gly Gly Gly Pro Arg Ala Ala Phe 450 455 460 cc acc ggc gtg aag ctg ctg tcc tac ctc tac cag gag gct ctg cac 1439 Pro Thr Gly Val Lys Leu Leu Ser Tyr Leu Tyr Gln Glu Ala Leu His 465 470 475 aac tgc agc aac gag cac tac cct gta ctg ctg tcc 1487 Asn Cys Ser Asn Glu His Tyr Pro Val Leu Leu Ser Leu Leu Lys Thr 480 485 490 495 agc tgc gag ccc tac acc cgg ttc atc cac gac tgg gtg tac agc ggg 1535 Ser Cys Glu Pro Tyr Thr Arg Phe Ile His Asp Trp Val Tyr Ser Gly 500 505 510 gtg ttc aga gac gct tat ggc gag ttc atg att cag gtg aac cac gag 1583 Val Phe Arg Asp Ala Tyr Gly Glu Phe Met Ile Gln Val Asn His Glu 515 520 525 tac ctc agc atg c tcga ttg tac tgg aca cat ggc tac gtg ctc 1631 Tyr Leu Ser Phe Arg Asp Lys Leu Tyr Trp Thr His Gly Tyr Val Leu 530 535 540 atc tcc aaa gag gtg gag gac tgt gtt ccc gtg ttt ctg aag cac att 1679 Lyle Glu Val Glu Asp Cys Val Pro Val Phe Leu Lys His Ile 545 550 555 gcc cac gac ata tac gtc tgc gga aag acc att aac ctg ctg aag ctc 1727 Ala His Asp Ile Tyr Val Cys Gly Lys Thr Ile Asn Leu Leu Lys Leu 560 565 570 575 tgc tgc ccc cgg cat tac ctc tgt tgg tcc gac gtc cct gtc ccc cgg 1775 Cys Cys Pro Arg His Tyr Leu Cys Trp Ser Asp Val Pro Val Pro Arg 580 585 590 atc tcg gtg att ttc tcc cttgag gag tt gag att gag aag gac 1823 Ile Ser Val Ile Phe Ser Leu Glu Glu Leu Lys Glu Ile Glu Lys Asp 595 600 605 tgt gcc gtc tac gtt ggg cgc atg gag agg gtg gcc cgc cac agc tct 1871 Cys Ala Val Tyr Val Gly Arg Glu Arg Val Ala Arg His Ser Ser 610 615 620 gtc agc aag gag gag aag gaa tta cgt atg gaa att gca aaa caa gaa 1919 Val Ser Lys Glu Glu Lys Glu Leu Arg Met Glu Ile Ala Lys Gln Glu 625 630 635 tta atc cat gcc cgg gaa gca gca tcc agg gtc ctg agt gca ctg 1967 Leu Ile Ale His Ala Arg Glu Ala Ala Ser Arg Val Leu Ser Ala Leu 640 645 650 655 agt gac cgg cag atg tca gaa cgg atg gcc ttg gat gcc agg ag cgt 2015 Ser Asp Arg Gln Met Ser Glu Arg Met Ala Leu Asp Ala Arg Lys Arg 660 665 670 gag cag ttt cag agg ctg aaa gaa caa ttt gtg aag gac cag gag cga 2063 Glu Gln Phe Gln Arg Leu Lys Glu Gln Phe Lys Asp Gln Glu Arg 675 680 685 cgc cag gcg gcc agg cag gag gag ctg gat gat gac ttc agc tac gcc 2111 Arg Gln Ala Ala Ala Arg Gln Glu Glu Leu Asp Asp Asp Phe Ser Tyr Ala 690 695 700cgt ggac gag aga agg ctg aag tcc ctg gag gag gag 2159 Arg Glu Leu Arg Asp Arg Glu Arg Arg Leu Lys Ser Leu Glu Glu Glu 705 710 715 ctg gag agg aag gcg agg cag gca ctg gtc gac cac tac agc aag gag agc aag cag tag agc aag cag tag agc aag cag Lys Ala Arg Gln Ala Leu Val Asp His Tyr Ser Lys Leu 720 725 730 735 tct gca gag gca gct cgt cgg gag cag aag gca ctg tgg aga atc cag 2255 Ser Ala Glu Ala Ala Arg Arg Glu Gln Lys Ala Leu Trp Arg Ile Gln 740 745 750 agg cac cga ctg gag agt gca cgg ctt cgt ttt ctc tta gaa gat gag 2303 Arg His Arg Leu Glu Ser Ala Arg Leu Arg Phe Leu Leu Glu Asp Glu 755 760 765 aaa cac att cag gag atg ctg aaa g g tct gag gct cac cag ccc 2351 Lys His Ile Gln Glu Met Leu Lys Ala Val Ser Glu Ala His Gln Pro 770 775 780 cag gag ccg cca gac gtc ctc ttg agc gtg cac ccc cag gtc acg tct 2399 Gln Glu Pro Asp Val Leu Leu Ser Val His Pro Gln Val Thr Ser 785 790 795 ccg ggc cct gag cac cca gag gga ggc caa ggc tgt gat tct ggg tct 2447 Pro Gly Pro Glu His Pro Glu Gly Gly Gln Gly Cys Asp Ser Gly Ser 800 805 810 815 815 gca gag caa cac tcg cct gcc tgg gat ggc tgg aac agg cca ggc ctg 2495 Ala Glu Gln His Ser Pro Ala Trp Asp Gly Trp Asn Arg Pro Gly Leu 820 825 830 830 ctg acc cca cag ccc ctt aag cct cta gca gtg ggg ggc agg 2543 Leu Thr Pro Gln Pro Leu Lys Pro Leu Ala Val Gly Ala Gly Gly Arg 835 840 845 ggg ctg cag cag gcg gag ggg gcc aga ccc ttc tct gac agc ctc agc 2591 Gly Leu Gln Gln Ala Glu Phe Ag Ser Asp Ser Leu Ser 850 855 860 att gga gac ttc cta cct gtg ggc cca ggg gct gag ccg tcc gtg cag 2639 Ile Gly Asp Phe Leu Pro Val Gly Pro Gly Ala Glu Pro Ser Val Gln 865 870 875 875 act ggc atg gtc cc t ctc ctg gag gtg gcg ctg cag acc att aac ttg 2687 Thr Gly Met Val Pro Leu Leu Glu Val Ala Leu Gln Thr Ile Asn Leu 880 885 890 890 gac ctg ccc ccc tca gct cct ggg gag gca ccc gca gca gcc ag act Asp Leu Pro Pro Ser Ala Pro Gly Glu Ala Pro Ala Ala Ala Ser Thr 900 905 910 cag ccc tcc agg cca cag gag tac gac ttt agt act gtc ctg agg cca 2783 Gln Pro Ser Arg Pro Gln Glu Tyr Asp Phe Ser Thr Val Leu Arg Pro 915 920 925 gct gtg gcc acc tca cct gca cca ggg ccc ctg cag gct gca gag tgc 2831 Ala Val Ala Thr Ser Pro Ala Pro Gly Pro Leu Gln Ala Ala Glu Cys 930 935 940 agc ttg ggc agc tca ggg cta cag tgg gag gac agt tgt ggg aag 2879 Ser Leu Gly Ser Ser Gly Leu Gln Leu Trp Glu Asp Ser Cys Gly Lys 945 950 955 atg gat gcc tgt ggc tcc gcc tcg cgg gag act ctg ctc ccc tca cac 2927 Met Asp Ala Cys Gly Ala Ser Arg Glu Thr Leu Leu Pro Ser His 960 965 970 975 cca ccc agg cgt gct gct ctg gag gag ggg agc agc cag ccc aca gag 2975 Pro Pro Arg Arg Ala Ala Leu Glu Glu Glu Gly Ser Ser Gln Pro Thr Glu 980 985 990 cgg ctc ttt ggg cag gtg tca ggg ggt ggt ctt ccc aca ggg gac tac 3023 Arg Leu Phe Gly Gln Val Ser Gly Gly Gly Leu Pro Thr Gly Asp Tyr 995 1000 1005 gct tct gaa ata gct ccc acc cgg cca cgg tgg aac acc cac ggg cac 3071 Ala Ser Glu Ile Ala Pro Thr Arg Pro Arg Trp Asn Thr His Gly His 1010 1015 1020 gtg tct gac gcc agc atc agg gtc ggg gag aat gtg tca gat gtg gct 3119 Val Ser Asp Ala Ser Ile Arg Val Gly Glu Asn Val Ser Asp Val Ala 1025 1030 1035 ccc acc cag cca cgg tgg aac acc cac gga cac gta tcc aat gcc agc 3167 Pro Thr Gln Pro Arg Trp Asn Thr His Gly His Val Ser Asn Ala Ser 1040 1045 1050 1055 atc agc tta ggg gag tct gtg tca gat gtg gct ccc act cgg cca cgg 3215 Ile Ser Leu Gly Glu Ser Val Ser Asp Val Ala Pro Thr Arg Pro Arg 1060 1065 1070 tgg aac atc cat gga cat gtg tcc aac gcc agc atc agg gtc ggg gag 3263 Trp Asn Ile His Gly His Val Ser Asn Ala Ser Ile Arg Val Gly Glu 1075 1080 1085 aat gtg tca gat gtg gct ccc acc agg cca cgg tgg aat acc cac ggg 3311 Asn Val Ser Asp Val Ala Pro Thr Ar g Pro Arg Trp Asn Thr His Gly 1090 1095 1100 cac gtg tcc aac gcc agc atc agg gtt ggg gag aac gtg tcg gac gtg 3359 His Val Ser Asn Ala Ser Ile Arg Val Gly Glu Asn Val Ser Asp Val 1105 1110 1115 gct ccc acc cgg cca cgg tgg aac acc cat gga cac gtg tcc gat gcc 3407 Ala Pro Thr Arg Pro Arg Trp Asn Thr His Gly His Val Ser Asp Ala 1120 1125 1130 1135 agc atc agc ttg ggg gag tct gtg tca gac atg gct ccc gcc cgg cca 3455 Ser Ile Ser Leu Gly Glu Ser Val Ser Asp Met Ala Pro Ala Arg Pro 1140 1145 1150 cgg tgg aac acc cat gga cac gtg tct gat gcc agc atc ag agc ttg ggg 3503 Arg Trp Asn Thr His Gly His Val Ser Asp Ala Ser Ile Ser Leu Gly 1155 1160 1165 gag tct gtg tca gac atg gct ccc acc cgg cca cgg tgg aac acc cac 3551 Glu Ser Val Ser Asp Met Ala Pro Thr Arg Pro Arg Trp Asn Thr His 1170 1175 1180 gga cat gtg tct gac acc agc atc agg gtt ggg gag aac gta tcg gac 3599 Gly His Val Ser Asp Thr Ser Ile Arg Val Gly Glu Asn Val Ser Asp 1185 1190 1195 gtg gct ccc atc cgg tca cgg tgc aac acc cat gga cac gtg tcc ga c 3647 Val Ala Pro Ile Arg Ser Arg Cys Asn Thr His Gly His Val Ser Asp 1200 1205 1210 1215 gcc agc atc agc ttg ggg gag cct gtg tcg gat gtg gtt tcc acc cgg 3695 Ala Ser Ile Ser Leu Gly Glu Pro Val Ser Asp Val Val Ser Thr Arg 1220 1225 1230 cca cgg tgg aac acc cat gta ccc atc cct ccg ccc cac atg gtg ctg 3743 Pro Arg Trp Asn Thr His Val Pro Ile Pro Pro Pro His Met Val Leu 1235 1240 1245 ggg gct ctc tca cca gaa gct gag ccc aac aca ccc agg ccc caa cag 3791 Gly Ala Leu Ser Pro Glu Ala Glu Pro Asn Thr Pro Arg Pro Gln Gln 1250 1255 1260 agc ccc cct ggc cac acg tcc cag tca gcg ctc agc ctg gga gca cag 3839 Ser Pro Gly His Thr Ser Gln Ser Ala Leu Ser Leu Gly Ala Gln 1265 1270 1275 agc act gtg ctg gac tgt ggg cca cgg ctg cct gta gaa gtg ggg cca 3887 Ser Thr Val Leu Asp Cys Gly Pro Arg Leu Pro Val Glu Val Gly Pro 1280 1285 1290 1295 tct ctg tcc tcc ccc agc tcg ggc tgc ggg gag ggg agc atc agc gtg 3935 Ser Leu Ser Ser Pro Ser Ser Gly Cys Gly Glu Gly Ser Ile Ser Val 1300 1305 1310 ggg gag aac gtg tca gac gtg gct ccc acc caa cca tgg tgg ccc aac 3983 Gly Glu Asn Val Ser Asp Val Ala Pro Thr Gln Pro Trp Trp Pro Asn 1315 1320 1325 acc ccg gga gac agt gtc tct gaa gaa cta ggt cag agt agg gtg gct 4031 Thr Pro Gly Asp Ser Val Ser Glu Glu Leu Gly Gln Ser Arg Val Ala 1330 1335 1340 ggt ggt cag gag tgg gac tgt ggg acg cac aga gcc tgg gag gta ggc 4079 Gly Gly Gly Gln Glu Trp Asp Cys Gly Thr His Arg Ala Trp Glu Val Gly 1345 1350 1355 ggg cag tgg ggt tgg tgg cat gtg aag ttc ccc tca ggc ctc ctt gtc 4127 Gly Gln Trp Gly Trp Trp His Val Lys Phe Pro Ser Gly Leu Leu Val 1360 1365 1370 1375 agc cag gac ctg ggg tg cat ggg agg ggc tgc ttg agc 4175 Ser Gln Asp Leu Gly Cys Cys Gly Gly His Gly Arg Gly Cys Leu Ser 1380 1385 1390 cag ggc cgg ctc ggc tct gta ccc gcc aca ggc act cgg ccc 4217 Gln Gly Arg Leu Gly Ala Thr Gly Thr Arg Pro 1395 1400 1405 tgatgccctc gtgtccactt gtgtccacac aggccctggg aggagcgggg acactgagga 4277 cctctctcca aattggcctc tcaactcaca ggaagacaca gctgcccaga gcagcccagg 4337 ccgtggtgag gaggcggagg catcggcggc ggaggctcag ggtggggagc aggcctacct 4397 ggcaggcctg gcagggcagt accacttgga gcggtacccg gacagttacg agtccatgtc 4457 cgagccgccc attgctcatc ttttgcgccc cgtgcttccc cgggccttcg ccttccccgt 4517 ggacccccag gtccagtctg ccgctgatga gactgctgtg cagctgagcg agttgctgac 4577 gctgcccgtg ctcatgaagc gctccatcac ggcaccgctg gccgcccaca tctccttggt 4637 gaacaaggcc gctgtcgact acttcttcgt ggagctgcac ctggaggcgc actatgaggc 4697 actgcggcac ttcctgctga tggaggacgg cgagttcgcc cagtccctca gcgacctgct 4757 ctttgagaag cttggagctg ggcaaacgcc cggagagctg ctcaacccgc tggtgctgaa 4817 ctctgtgctg agcaaggccc tgcagtgcag cctgcatggg gacaccccgc acgcctccaa 4877 cctctccctc gctctcaagt acctgcccga ggtgtttgcc cccaacgccc cggatgtgct 4937 gagctgcctg gagctcaggt acaaggtgga ctggcctctc aacattgtca tcaccgaggg 4997 ctgcctgagc aagtacagcg gcgtcttctc cttcctgctg cagctgaagc tcatgatgtg 5057 ggcgctcaag gacgtctgct tccacctcaa gcgcacagcc ctgctgagcc acatggccgg 5117 ctctgtgcag ttccgtcagc tgcagctgtt caagcacgag atgcagcatt tcgtgaaggt 5177 c atccagggc tacatcgcca accagatcct gcacgtcacc tggtgcgagt tcagggccag 5237 gttggccacc gtgggcgacc tggaggagat ccagcgtgcg cacgcagagt acctgcacaa 5297 ggccgtcttc aggtgaggcc tgggcagcgg ctgcgtccct gtggtcacgg ctcagcccac 5357 ccagcagcac tgcttccccc ccctgggggc ccgcggggtg cagagcaccc caactttgca 5417 ctcatgcagc agtcctacaa caccttcaag tactactccc actttctctt caaagtggtg 5477 accaagctgg tgaaccgcgg ctaccagccc cacctggagg actttctgct gcgcatcaac 5537 ttcaacaact actaccagga cgcctgaggc tgctctgcgg gggacgtgca caataaaggt 5597 gttctcgg 5605 <210> 64 <211> 5265 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (295) .. (2955) <400> 64 gagcagcagg acttgcattt gttctcgcct gcctagtgtc ttccaaggga tagatgccgt 60 ttcctctgct ggtctctggg ggtgacgggg ggcgcagggg agcttcttgg gggaatcact 120 ccaactctgt ggagctggtg gtgctgcctg gtggggctct ctctttgccc gggacgtgga 180 acaactttca gctggaggac gagagggaat agtgaagcta aaggttgctt ttctctgcac 240 cgtccgttct tgctccctct gctccatcac tgggaccttg tcaggcgttc ataa agc 297 Ser 1 aaa att tgc cga acg agg gtt cgc aga aag gtg ggg cag agc tca tct 345 Lys Ile Cys Arg Thr Arg Val Arg Arg Lys Val Gly Gln Ser Ser Ser 5 10 15 gac gtg gca tca gcc cgt gat tgg tgg tct act att ctg gga gat aaa 393 Asp Val Ala Ser Ala Arg Asp Trp Trp Ser Thr Ile Leu Gly Asp Lys 20 25 30 gaa gaa ttt gat caa ggc tgt ttg tgt ctg gct aat gtt gac aat agt 441 Glu Glu Phe Asp Gln Gly Cys Leu Cys Leu Ala Asn Val Asp Asn Ser 35 40 45 gga aat gga caa gat aaa ata att gtg ggt agc ttt atg gga tac cta 489 Gly Asn Gly Gln Asp Lys Ile Ile Val Gly Ser Phe Met Gly Tyr Leu 50 55 60 65 agg atc ttt agc ccc cat cct gca aaa aca gga gat gga gct caa gcc 537 Arg Ile Phe Ser Pro His Pro Ala Lys Thr Gly Asp Gly Ala Gln Ala 70 75 80 gaa gat ttg ctt cta gaa gtg gat cta cga gat cca gta ctt caa gtg 585 Glu Asp Leu Leu Leu Glu Val Asp Leu Arg Asp Pro Val Leu Gln Val 85 90 95 gaa gta gga aag ttt gtt tca ggt acc gaa atg cta cat ttg gct gtg 633 Glu Val Gly Lys Phe Val Ser Gly Thr Glu Met Leu His Leu Ala Val 100 105 110 tta cat tct aga aaa ctt tgt gtc tac tct gtc tca gga acc ttg ggt 681 Leu His Ser Arg Lys Leu Cys Val Tyr Ser Val Ser Gly Thr Leu Gly 115 120 125 aat gtg gaa cat ggg aac caa tgt cag atg aaa ttg atg tat gaa cat 729 Asn Val Glu His Gly Asn Gln Cys Gln Met Lys Leu Met Tyr Glu His 130 135 140 145 aat ctt cag aga aca gcc tgc aat atg acc tat gga tca ttt ggt ggt 777 Asn Leu Gln Arg Thr Ala Cys Asn Met Thr Tyr Gly Ser Phe Gly Gly 150 155 160 gta aaa ggt cga gat tta att tgc atc cag tct atg gat ggg atg ctg 825 Val Lys Gly Arg Asp Leu Ile Cys Ile Gln Ser Met Asp Gly Met Leu 165 170 175 atg gta ttt gag cag gag agc tat gct ttt gga caga ttt ggc 8 73 Met Val Phe Glu Gln Glu Ser Tyr Ala Phe Gly Arg Phe Leu Pro Gly 180 185 190 ttt ctt ctg cct ggt cct ctt gcc tac agt tcc cgt aca gat tcc ttc 921 Phe Leu Leu Pro Gly Pro Leu Ala Tyr Ser Ser Arg Thr Asp Ser Phe 195 200 205 ctt act gtc tct tcc tgc caa caa gtg gaa agt tat aag tac cag gta 969 Leu Thr Val Ser Ser Cys Gln Gln Val Glu Ser Tyr Lys Tyr Gln Val 210 215 220 225 ctt gct ttt gca aca gat gca gat aaa agg cag gag act gaa cag caa 1017 Leu Ala Phe Ala Thr Asp Ala Asp Lys Arg Gln Glu Thr Glu Gln Gln 230 235 240 aaa ctt ggt tct gga aaa aga cta gtt gtg gat tgg act cta aat att 1065 Lys Leu Gly Ser Gly Lys Arg Leu Val Val Asp Trp Thr Leu Asn Ile 245 250 255 gga gag caa gcc ctt gac ata tgt att gtc tct ttc aat cag tcg gca 1113 Gly Glu Gln Ala Leu Asp Ile Cys Ile Val Ser Phe Asn Gln Ser Ala 260 265 270 tcc tct gtt ttt gtt ctt ggt gag aga aac ttt ttt tgc ctt aag gat 1161 Ser Ser Val Phe Val Leu Gly Glu Arg Asn Phe Phe Cys Leu Lys Asp 275 280 285 aat gga caa att cga ttc atg aag aag ctt gat tgg agg gc cca agt tgt 1209 Asn Gly Gln Ile Arg Phe Met Lys Lys Leu Asp Trp Ser Pro Ser Cys 290 295 300 305 ttt ctg cca tat tgc tca gtt tct gaa gga aca ata aat act ttg att 1257 Phe Leu Pro Tyr Cys Ser Val Ser Glu Gly Thr Ile Asn Thr Leu Ile 310 315 320 gga aat cat aat aac atg ctg cat att tat caa gat gtg aca ctg aag 1305 Gly Asn His Asn Asn Met Leu His Ile Tyr Gln Asp Val Thr Leu Lys 325 330 335 tgg gcc acc caa ctt ccc cac att cct gta gca gta aga gtg ggc tgt 1353 Trp Ala Thr Gln Leu Pro His Ile Pro Val Ala Val Arg Val Gly Cys 340 345 350 ttg cat gat tta aag gga gtg ata gtc act ctg agt gat gat ggt cac 1401 Leu His Asp Leu Lys Gly Val Ile Val Thr Leu Ser Asp Asp Gly His 355 360 365 ttg cag tgt tca tac ctg ggg aca gat cct tct ctg ttc caa gct cca 1449 Leu Gln Cys Ser Tyr Leu Gly Thr Asp Pro Ser Leu Phe Gln Ala Pro 370 375 380 385 aac gtt caa tct cga gaa cta aac tat gat gaa ctt gat gta gaa atg 1497 Asn Val Gln Ser Arg Glu Leu Asn Tyr Asp Glu Leu Asp Val Glu Met 390 395 400 aaa gaa ctt cag aaa atc at c aaa gat gtt aac aaa tca caa ggt gtt 1545 Lys Glu Leu Gln Lys Ile Ile Lys Asp Val Asn Lys Ser Gln Gly Val 405 410 415 tgg ccc atg act gag aga gaa gat gac ttg aac gtt tct gtc gtg gtt 1593 Trp Pro Met Thr Glu Arg Glu Asp Asp Leu Asn Val Ser Val Val Val 420 425 430 tct cct aac ttt gat tca gtt tct caa gcg acc gat gtt gag gtg gga 1641 Ser Pro Asn Phe Asp Ser Val Ser Gln Ala Thr Asp Val Glu Val Gly 435 440 445 act gac ctt gtc cct tct gtc acg gtg aag gtc aca ctg cag aac aga 1689 Thr Asp Leu Val Pro Ser Val Thr Val Lys Val Thr Leu Gln Asn Arg 450 455 460 465 gtg ata ttg caa aaa gcc aaa tta tca gtc tac gtg caa cca cca tta 1737 Val Ile Leu Gln Lys Ala Lys Leu Ser Val Tyr Val Gln Pro Pro Leu 470 475 480 gaa ttg act tgt gat cag ttc acc ttt gaa ttt atg aca cca gat ttg 1785 Glu Leu Thr Cys Asp Gln Phe Thr Phe Glu Phe Met Thr Pro Asp Leu 485 490 495 act aga aca gta agc ttt tct gtt tat ctg aaa aga agt tat aca cca 1833 Thr Arg Thr Val Ser Phe Ser Val Tyr Leu Lys Arg Ser Tyr Thr Pro 500 505 510 tca gaa ttg gaa gga aat gct gtt gtt tct tat tcc aga cca aca gat 1881 Ser Glu Leu Glu Gly Asn Ala Val Val Ser Tyr Ser Arg Pro Thr Asp 515 520 525 cga aat cct gat ggc att ccg cga gtt atc caa tgt aaa ttt aga ctt 1929 Arg Asn Pro Asp Gly Ile Pro Arg Val Ile Gln Cys Lys Phe Arg Leu 530 535 540 545 ccc cta aag tta att tgc cta cca ggt cag cct tca aaa act gca agc 1977 Pro Leu Lys Leu Ile Cys Leu Pro Gly Gln Pro Ser Lys Thr Ala Ser 550 555 560 cac aaa att act att gat acc aac aaa tct cca gtc agt ctt ctt agt 2025 His Lys Ile Thr Ile Asp Thr Asn Lys Ser Pro Val Ser Leu Leu Ser 565 570 575 ctc ttc cca ggt ttt gcc agt cag tca gat gat gat cag gtg aat gta 2073 Leu Phe Pro Gly Phe Ala Ser Gln Ser Asp Asp Asp Gln Val Asn Val 580 585 590 atg ggt ttt cac ttc tta gga ggt gct cga att act gtt ctt gct tcc 2121 Met Gly Phe His Phe Leu Gly Gly Ala Arg Ile Thr Val Leu Ala Ser 595 600 605 aaa act tct caa cga tat cgc att cag agt gaa caa ttt gaa gat ctt 2169 Lys Thr Ser Gln Arg Tyr Arg Ile Gln Ser Glu Gln Phe Glu Asp Leu 610 615 620 625 tgg ctc ata acc aat gag ctt att ctt cgc ctt caa gaa tat ttt gaa 2217 Trp Leu Ile Thr Asn Glu Leu Ile Leu Arg Leu Gln Glu Tyr Phe Glu 630 635 640 aaa cag gga gtc gat tt g ttt tcg gga tct ata ccc 2265 Lys Gln Gly Val Lys Asp Phe Ala Cys Ser Phe Ser Gly Ser Ile Pro 645 650 655 ctt caa gaa tat ttt gag ttg att gat cat cat ttt gag cta cgg ata 2313 Leu Gln Glu Tyr Phe Glu Leu Ile Asp His His Phe Glu Leu Arg Ile 660 665 670 aat ggt gaa aaa tta gaa gaa ctc tta tct gag aga gct gta caa ttt 2361 Asn Gly Glu Lys Leu Glu Glu Leu Leu Ser Glu Arg Ala Val Gln Phe 675 685 cgg att caa cgc cgg cta cta gca aga ttc aaa gat aaa act cct 2409 Arg Ala Ile Gln Arg Arg Leu Leu Ala Arg Phe Lys Asp Lys Thr Pro 690 695 700 705 gcc cct ctt caa cac ctg gac acc ttg tta gat gga acc tag cag 2457 Ala Pro Leu Gln His Leu Asp Thr Leu Leu Asp Gly Thr Tyr Lys Gln 710 715 720 gta att gct cta gca gat gca gtg gag gaa aac caa ggc aat ctg ttc 2505 Val Ile Ala Leu Ala Asp Ala Val Glu Glu Asn Gln Gly Asn Leu Phe 725 730 735 cag tca ttc acc agg ctg aag agt gcc acc cat ttg gtg att ctg ctg 2553 Gln Ser Phe Thr Arg Leu Lys Ser Ala Thr His Leu Val Ile Leu Leu 740 745 750 atc gcg ctg tgg aag ctt agt gct gac cag gtt gct att ctg gaa 2601 Ile Ala Leu Trp Gln Lys Leu Ser Ala Asp Gln Val Ala Ile Leu Glu 755 760 765 gcg gca ttt ctg ccg cta caa gaa gac act caa gac Agg ggg ggg gg Phe Leu Pro Leu Gln Glu Asp Thr Gln Glu Leu Gly Trp Glu 770 775 780 780 785 gaa acg gtg gat gcc gcc att tcc cac ctg ttg aag act tgc ctg tcg 2697 Glu Thr Val Asp Ala Ala Ile Ser His Leu Leu Lys Thr Cys Ser 790 795 800 aag agt tct aag gag cag gct ttg aac ctc aac agc cag ctg aac ata 2745 Lys Ser Ser Lys Glu Gln Ala Leu Asn Leu Asn Ser Gln Leu Asn Ile 805 810 815 ccc aaa gac aca agc caa ctg aag atc acc ttg ctc tgc gat 2793 Pro Lys Asp Thr Ser Gln Leu Lys Lys His Ile Thr Leu Leu Cys Asp 820 825 830 aga tta tcc aaa ggt ggc cgt ctc tgc cta agt acc gat gca gca gcc 2841 Arg Leu Ser Lys Gly G ly Arg Leu Cys Leu Ser Thr Asp Ala Ala Ala 835 840 845 cca cag acc atg gtc atg cca gac ccc agg act gga cag agg atc gag 2889 Pro Gln Thr Met Val Met Pro Asp Pro Arg Thr Gly Gln Arg Ile Glu 850 855 855 860 865 gcc tgg acc cta aga ata ccc cac tcc ctg agc cag cat ctc cag ctg 2937 Ala Trp Thr Leu Arg Ile Pro His Ser Leu Ser Gln His Leu Gln Leu 870 875 880 atg gag gga ccc aaa agc taagcggggt caatcagacacccct Pro Lys Ser 885 gatggttaaa actgggacag gccaatggag aaggtccttc tgtctttggt ctgtgatgcg 3045 aggaacacag ggatctttcc tgttgtgtgg agaaagagga gcccagagcc gtactgagcc 3105 aagggggtgc cagggagagg ctgccaggcc tgggccctgg aaccagcccc ccaaggccct 3165 ggaaccagcc tgctccatgc agctgcggct cttccagtct gtgagctact cagtgccctt 3225 tcaacaaacc ccgccttgtt ttgctttaat cagtttgcat tttctgttgc ttctttctgg 3285 aaaaatcctc tgtgctttga ctgactccag ggtcttcctc cttgaggtgg atttcttagt 3345 cactgttagg tatccaaata taggcgagtg taaggcattt ttctttcaac tgttcatttt 3405 aatgaattac attcaggaaa taagtaggaa attaaattca ttgaaagact attggtct gt 3465 atgtactttt tcagcctaac atgctcaaag cgtaggtagc aggcagctat aatacagaca 3525 ttttattttt taaagggcaa agacaatggt aatttaattt tagatcattc cagatggagt 3585 tcaagtcaac gtgctgatga ctggagacct gacagaaatt aaatgttggt tattgcgtcc 3645 caatttcaga ttatgaccca atcaagggtc acttgaggat atccaaaagg ttgggaagat 3705 tacaataatt ttaaaaacac aagaaagtgg tttctacctc tgagctatac atatttattg 3765 ggttggagga aagggataat tttctaaagg gaaggggcac tgtggaagaa gaggcagctc 3825 tggaagccag ccaagggcaa cagcaaggag gcagccccag ccgagggcgg gtttctgagc 3885 agagtggaca ccagacagga gtttgcagat ggtccattgg gtagagcgta gggtagaaaa 3945 gtaggtttca tcttatatga caatttttga cagataatga agactatggg gagaattgtg 4005 tccagaaata gtctgaggct gaatgtgggc ttaatggggc agccatgatt atttatcagt 4065 ggcaggtagt ctgagcagag ctgattctgg tgctcccacg tggatcaagt atatcccatc 4125 tccaattcag tctccacagc agagggagta aataattcca cctcaccaca acggagccat 4185 atgtgatgag tgcccactag ttacatgaaa ttgggcaggg aggaatttat gttagcctac 4245 atacaagtct gaacataact cacgtcagca ttgccatggg aagtcaatat attgctgggt 430 5 gttggcaaat attgagttta gatgactctt cctgtaaagg atagaaacat tgtttttaaa 4365 acttcaattt aggctgatga gaaaatacta tagaaggaag gagaacatct tgaagattta 4425 aaaaatgatc tataagctct ggaaggaaat ttttagaaaa atgattgagg caccagcaat 4485 tagcctaagc aaaaaacaaa acaaaacaaa aacacagtct ctgaaaaaaa acacactcaa 4545 aggagagttc aaactgacat aaagagacaa tggaataaga tgacatttac ttattttatt 4605 ttcctttagg tttatttggt ctttttctat cttcttttag ctgaattagt tcttttgtat 4665 tcaatttttt taattttcta atacatatag ttaagatgat aaaattttct ctgagtacca 4725 atttgactgc attccataat ggttttcaaa taatttttta ttttgaattt ttgtgggtac 4785 atagtaggtg tatgtattta tggtatacat gagatgtttt gacacaagct tgcaaacctt 4845 ccataacttt tgctatgctg cattgaaagt attgtgatat ttcaggtttg atttcctcct 4905 gtgtgcaagt tatttaaaaa gaagtattaa atacattcta aatgaagggg attttttccc 4965 ctatgttttg aatattactt tctagttcta ttacattatg atcaggaaat gagccctctg 5025 tgatttttac tttcataatt tatggaggtt ttttccttga ggaccattac atcaccattt 5085 tttggtaaat attctgaaat cttacatttg cccaacctga tctgttgatt tgtgagagat 5145 tag gtcaaag ttttccacaa tgacattgga tttgttaata tctccttatc cttccaaaat 5205 ttttacttta tatgctacta tttaggtgaa taaagattca caaaaatgtt tccaccttct 5265 <210> 65 <211> 4917 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2069) <400> 65 ag aag atg tct tcg cgg acg gtg ctg gcc ccg ggc aac gat cgg aac 47 Lys Met Ser Ser Arg Thr Val Leu Ala Pro Gly Asn Asp Arg Asn 1 5 10 15 tcg gac acg cat ggc acc ttg ggc agt ggc cgc tcc tcg gac aaa ggc 95 Ser Asp Thr His Gly Thr Leu Gly Ser Gly Arg Ser Ser Asp Lys Gly 20 25 30 ccg tcc tgg tcc agc cgc tca ctg ggt gcc cgt tgc cgg aac tcc atc 143 Pro Ser Trp Ser Ser Arg Ser Leu Gly Ala Arg Cys Arg Asn Ser Ile 35 40 45 gcc tcc tgt ccc gag gag cag ccc cac gtg ggc aac tac cgc ctg ctg 191 Ala Ser Cys Pro Glu Glu Glu Gln Pro His Val Gly Asn Tyr Arg Leu Leu 50 55 60 agg acc att ggg aag ggc aac ttt gcc aaa gtc aag ctg gct cgg cac 239 Arg Thr Ile Gly Lys Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His 65 70 75 atc ctc act ggt cgg gag gtt gcc atc aag att atc gac aaa acc cag 287 Ile Leu Thr Gly Arg Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln 80 85 90 95 ctg aat ccc agc agc ctg cag aag ctg ttc cga gaa gtc cgc atc atg 335 Leu Asn Pro Ser Ser Leu Gln Lysluu Phe Arg Val Arg Ile Met 100 105 110 aag ggc cta aac cac ccc aac atc gtg aag ctc ttt gag gtg att gag 383 Lys Gly Leu Asn His Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu 115 120 125 act gag aag acg ctg tac ctg gtg atg gag tac gca ag gct gaa 431 Thr Glu Lys Thr Leu Tyr Leu Val Met Glu Tyr Ala Ser Ala Gly Glu 130 135 140 gtg ttt gac tac ctc gtg tcg cat ggc cgc atg aag gag aag gaa gct 479 Val Phe Asp Tyr Leu Val Ser His Gly Arg Met Lys Glu Lys Glu Ala 145 150 155 cga gcc aag ttc cga cag att gtt tcg gct gtg cac tat tgt cac cag 527 Arg Ala Lys Phe Arg Gln Ile Val Ser Ala Val His Tyr Cys His Gln 160 165 170 175 aaa aat att gta cac agg gac ctg aag gct gag aac ctc ttg ctg gat 575 Lys Asn Ile Val His Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp 180 185 190 gcc gag gcc aac atc aag att gct gac ttt ggc ttc agc aac Gag ttc 623 Asn Ile Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe 195 200 205 acg ctg gga tcg aag ctg gac acg ttc tgc ggg agc ccc cca tat gcc 671 Thr Leu Gly Ser Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala 210215 220 gcc ccg gag ctg ttt cag ggc aag aag tac gac ggg ccg gag gtg gac 719 Ala Pro Glu Leu Phe Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp 225 230 235 235 atc tgg agc ctg gga gtc atc ctg tc accc agc ggc tcc ctg 767 Ile Trp Ser Leu Gly Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu 240 245 250 255 ccc ttc gac ggg cac aac ctc aag gag ctg cgg gag cga gta ctc aga 815 Pro Phe Asp Gly His Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg 260 265 270 270 ggg aag tac cgg gtc cct ttc tac atg tca aca gac tgt gag agc atc 863 Gly Lys Tyr Arg Val Pro Phe Tyr Met Ser Thr Asp Cys Glu Ser Ile 275 280 280 285 ctg cgg aga ttt ttg gtg ctg aac cca gct aaa cgc tgt act ctc gag 911 Leu Arg Arg Phe Leu Val Leu Asn Pro Ala Lys Arg Cys Thr Leu Glu 290 295 300 caa atc atg aaa gac aaa tgg atc aac atc ggc tat gag ggt gag gag Gln Ile Met Lys Asp Lys Trp Ile Asn Ile Gly Tyr Glu Gly Glu Glu 305 310 315 ttg aag cca tac aca gag ccc gag gag gac ttc ggg gac acc aag aga 1007 Leu Lys Pro Tyr Thr Glu Pro Glu Glu Asp Phe Gly Asp Th r Lys Arg 320 325 330 335 att gag gtg atg gtg ggt atg ggc tac aca cgg gaa gaa atc aaa gag 1055 Ile Glu Val Met Val Gly Met Gly Tyr Thr Arg Glu Glu Ile Lys Glu 340 345 350 tcc ttg acc agc cag aag aac gaa gtg acc gcc acc tac ctc ctg 1103 Ser Leu Thr Ser Gln Lys Tyr Asn Glu Val Thr Ala Thr Tyr Leu Leu 355 360 365 ctg ggc agg aag act gag gag ggt ggg gac cgg ggc gcc cca ggg ctg 1151 Leu Gly Arg Lys Thr Glu Glu Gly Gly Asp Arg Gly Ala Pro Gly Leu 370 375 380 gcc ctg gca cgg gtg cgg gcg ccc agc gac acc acc aac gga aca agt 1199 Ala Leu Ala Arg Val Arg Ala Pro Ser Asp Thr Thr Asn Gly Thr Ser 385 390 395 tcc agc aaa ggc acc agc cac agc aaa ggg cag cgg agt tcc tct tcc 1247 Ser Ser Lys Gly Thr Ser His Ser Lys Gly Gln Arg Ser Ser Ser Ser 400 405 410 415 acc tac cac cgc cag cgc agg cat agc gat ttc tgt ggc cca tcc cct 1295 Thr Tyr His Arg Gln Arg Arg His Ser Asp Phe Cys Gly Pro Ser Pro 420 425 430 gca ccc ctg cac ccc aaa cgc agc ccg acg agc acg ggg gag gcg gag 1343 Ala Pro Leu His Pro Lys Arg Ser Pro Thr Ser Thr Gly Glu Alu Glu 435 440 445 ctg aag gag gag cgg ctg cca ggc cgg aag gcg agc tgc agc acc gcg 1391 Leu Lys Glu Glu Arg Leu Pro Gly Arg Lys Ala Ser Cys Ser Thr Ala 450 455 460 ggg agt agt cga ggg ctg ccc ccc tcc agc ccc atg gtc agc agc 1439 Gly Ser Gly Ser Arg Gly Leu Pro Pro Ser Ser Pro Met Val Ser Ser 465 470 475 gcc cac aac ccc aac aag gca gag atc cca gag cgg cgg aag gac agc 1487 Ala His Asn Pro Asn Lys Ala Glu Ile Pro Glu Arg Arg Lys Asp Ser 480 485 490 495 acg agc acc ccc aac aac ctc cct cct agc atg atg acc cgc aga aac 1535 Thr Ser Thr Pro Asn Asn Leu Pro Pro Ser Met Met Thr Arg Arg Asn 500 505 510 acc tac gtt tgc aca gaa cgc ccg ggg gct gag cgc ccg tca ctg ttg 1583 Thr Tyr Val Cys Thr Glu Arg Pro Gly Ala Glu Arg Pro Ser Leu Leu 515 520 525 525 cca aat ggg aaa gaaaac ggc acc cca cgg gtg ccc cct gcc 1631 Pro Asn Gly Lys Glu Asn Ser Ser Gly Thr Pro Arg Val Pro Pro Ala 530 535 540 tcc ccc tcc agt cac agc ctg gca ccc cca tca ggg gag cgg agc cgc 1679 Ser Pro Ser Ser His Ser Leu Ala Pro Pro Ser Gly Glu Arg Ser Arg 545 550 555 ctg gca cgc ggt tcc acc atc cgc agc acc ttc cat ggt ggc cag gtc 1727 Leu Ala Arg Gly Ser Thr Ile Arg Ser Thr Phe His Gly Gly Gln Val 560 565 570 575 cgg gac cgg cgg gca ggg ggt ggg ggt ggt ggg ggt gtg cag aat ggg 1775 Arg Asp Arg Arg Ala Gly Gly Gly Gly Gly Gly Gly Gly Val Gln Asn Gly 580 585 590 ccc cct gcc tct ccc aca ctg gcc cat gca ccc ctg ccc gcc 1823 Pro Pro Ala Ser Pro Thr Leu Ala His Glu Ala Ala Pro Leu Pro Ala 595 600 605 ggg cgg ccc cgc ccc acc acc aac ctc ttc acc aag ctg acc tcc aaa 1871 Gly Arg Pro Arg Pro Thr Thr Asn Leu Phe Thr Lys Leu Thr Ser Lys 610 615 620 ctg acc cga agg gtt acc ctc gat ccc tct aaa cgg cag aac tct aac 1919 Leu Thr Arg Arg Val Thr Leu Asp Pro Ser Lys Arg Gln Asn Ser Asn 625 630 635 635 cgc tgt gtt tcg ggc gcc tct ctg ccc cag gga tcc aag atc agg tcg 1967 Arg Cys Val Ser Gly Ala Ser Leu Pro Gln Gly Ser Lys Ile Arg Ser 640 645 650 650 cag acg aac ctg aga gaa tcg ggg gac ctg agg tca cag c atc 2015 Gln Thr Asn Leu Arg Glu Ser Gly Asp Leu Arg Ser Gln Val Ala Ile 660 665 670 tac ctt ggg atc aaa cgg aaa ccg ccc ccc ggc tgc tcc gat tcc cct 2063 Tyr Leu Gly Ile Lys Arg Lys Pro Pro Gly Cys Ser Asp Ser Pro 675 680 685 gga gtg tgaagctgac cagctcgcgc cctcctgagg ccctgatggc agctctgcgc 2119 Gly Val caggccacag cagccgcccg ctgccgctgc cgccagccac agccgttcct gctggcctgc 2179 ctgcacgggg gtgcgggcgg gcccgagccc ctgtcccact tcgaagtgga ggtctgccag 2239 ctgccccggc caggcttgcg gggagttctc ttccgccgtg tggcgggcac cgccctggcc 2299 ttccgcaccc tcgtcacccg catctccaac gacctcgagc tctgagccac cacggtccca 2359 gggcccttac tcttcctctc ccttgtcgcc ttcacttcta caggagggga aggggccagg 2419 gaggggattc tccctttatc atcacctcag tttccctgaa ttatatttgg gggcaaagat 2479 tgtcccctct gctgttctct ggggccgctc agcacagaag aaggatgagg gggctcagcg 2539 gggggagctg gcaccttcct ggagcctcca gccagtcctg tcctccctcg ccctaccaag 2599 agggcacctg aggagacttt ggggacaggg caggggcagg gagggaaact gaggaaatct 2659 tccattcctc ccaacagctc aaaattaggc cttgggcagg ggcaggga ga gctgctgagc 2719 ctaaagactg gagaatctgg gggactggga gtgggggtca gagaggcaga ttccttcccc 2779 tcccgtcccc tcacgctcaa acccccactt cctgccccag gctggcgcgg ggcactttgt 2839 acaaatcctt gtaaataccc cacaccctcc cctctgcaaa ggtctcttga ggagctgccg 2899 ctgtcaccta cggtttttaa gttattacac cccgaccctc ctcctgtcag ccccctcacc 2959 tgcagcctgt tgcccaataa atttaagaga gtccccccct ccccaatgct gaccctagga 3019 ttttccttcc ctgccctcac ctgcaaatga gttaaagaag aggcgtggga atccaggcag 3079 tggtttttcc tttcggagcc tcggttttct catctgcaga atgggagcgg tgggggtggg 3139 aaggtaagga tggtcgtgga agaaggcagg atggaactcg gcctcatccc cgaggcccca 3199 gttcctatat cgggcccccc attcatccac tcacactccc agccaccatg ttacactgga 3259 ctctaagcca cttcttactc cagtagtaaa tttattcaat aaacaatcat tgacccatgc 3319 ctactccatg ccaggcccag tgctggacac agagacatga agctctgtct gtgggagaca 3379 gggattctga cacagacacc ggacaaacca ttgtcttggg gagcccagaa gagaaagtgg 3439 gcagggtggg gtcattgggg aagatgctct agaggaatta atgctggaat ggggtgttga 3499 aggatgagta ggagttagtt aggcattgag tttgccctgg gcaaaagccc aga agtggga 3559 gtatgtggta tatcttcaga gaactgggta atttcagtgt ggctgctgtg ttgggcatgg 3619 atggagaatc agcaagagaa atgctgtatt aggactaata atccatctac gctgcttaag 3679 caaaaaggta tttgttggtt tatgttactt aatagtccag gggcacctgg cttcaggtag 3739 gtttgatcca ggcatcaggc cattgcatct attttttcag tgtaagttga attctagtaa 3799 tttttatcaa gtaagggctc ctttcctggt ggcacagatg acttcagcag ttagaagttt 3859 ctatccctcc agctttctgc agcagaaaga ccctcattgt cagtttccca gcaaaagtcc 3919 cagggcagac tctcattggc ccaaatgggc catgtgattt tctctaaacc aatcactgtg 3979 actctagagt ggccagactc agagctgcac ttagtagggg ttcctcaaag gaaggtcaag 4039 tgtcatgagc aggagaaaag gcatgggagc tggacagatt atagtggttg aagtctgtgc 4099 agtacagaag ggcggagctt attcacacag cacctttggg gccaaaatga ataagctgga 4159 ctttctcccc atggcactgg ggaaccatgg aagttcaggg aacttcaggg aagaggcttg 4219 gtcaattcct gagagcatcc tctgtgctgg ggacacagtg gtaatcaaga cagccccaac 4279 actgccctca tagagctcac agtccaatgg aggaggcaga tgtgtcctca ggcagcgact 4339 gggcagggct ggtatagggg agtccagagg tgatgcctgc ctcagccagg gagggctt cc 4399 tggaggagaa ggagccagct agacatggat aggagtgcgt tttaggcaca gcaaatggca 4459 catacaaggg ccagggagca agagagagga caggtcctca acaaatggca tgtgactttg 4519 taagtgtaga attgctgtga ggtatggggc taggggcgtc agtagggcct tgaaggttat 4579 ggacaggggc ctgggctttc ttccaagggc actgggggag ccatggcaag gttgtaggta 4639 gggtagagat gggcgggttt gtgctatgtg cagggtggaa gggagggaag ttgacaggtc 4699 agaagatcag gaaagaggtc ggggctggac agatggggag agcgcagata gatttaagag 4759 agtcctgtga ggcaaagtgg gcaggacctg gtaacaggtg tctggactgt ggctttggct 4819 ggctcagaag gtccccactg gcgtgtgtgg tctatgtagc ctctgggtgt ggagctggga 4879 tcttcaactg gggacagtac agtaaagaac atcacagc 4917 <210> 66 <211> 5765 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1565) <400> 66 gc cat gtc ctg caa ttt atg tac tat gga act ata gag ctg agt atg 47 His Val Leu Gln Phe Met Tyr Tyr Gly Thr Ile Glu Leu Ser Met 1 5 10 15 aat acc gtt cat gag att ctt cag gct gcc atg tat gtt caa ctt ata 95 Asn Thr Val His Glu Ile Leu Gln Ala Ala Met Tyr Val Gln Leu Ile 20 25 30 gaa gtg gtg aag ttc tgc tgc tct ttt ctc tta gcg aag atc tgc cta 143 Glu Val Cys Phe Cys Ser Phe Leu Leu Ala Lys Ile Cys Leu 35 40 45 gaa aat tgt gca gaa att atg aga ctc tta gat gat ttc ggc gta aac 191 Glu Asn Cys Ala Glu Ile Met Arg Leu Leu Asp Asp Phe Gly Val Asn 50 55 60 atc gag gga gtc agg gag aag tta gac acc ttt ctg cta gac aac ttt 239 Ile Glu Gly Val Arg Glu Lys Leu Asp Thr Phe Leu Leu Asp Asn Phe 65 70 75 gtg cca ctc atg tct agg cct gac ttt ctg gcc ttat ctg ag 287 Val Pro Leu Met Ser Arg Pro Asp Phe Leu Ser Tyr Leu Ser Phe Glu 80 85 90 95 aag ctc atg tct tac ttg gat aat gat cat ctg agc agg ttc cca gag 335 Lys Leu Met Ser Tyr Leu Asp Asn Asp His Leu Ser Arg Phe Pro Glu 100 105 110 ata gag ctg tac gag gct gtg cag tct tgg ctg cgg cat gat aga aga 383 Ile Glu Leu Tyr Glu Ala Val Gln Ser Trp Leu Arg His Asp Arg Arg 115 120 125 cgc tgg aga cat acc gat acc atc att cag aat atc cgg ttt tgc ttg 431 Arg Trp Arg His Thr Asp Thr Ile Ile Gln Asn Ile Arg Phe Cys Leu 130 135 140 atg acc cca acc agc gtt ttt gag aag gtt aag aca tca gaa ttt tat 479 Met Thr Pro Thr Ser Val Phe Glu Lys Val Lys Thr Ser Glu Phe Tyr 145 150 155 aga tac tcc cga cag ctc cgt tac gaa gtt gac caa gca ttg aat tac 527 Arg Tyr Ser Arg Gln Leu Arg Tyr Glu Val Asp Gln Ala Leu Asn Tyr 160 165 170 175 ttt cag aat gtt cac ca cag cct ttg ttg gat atg aag tca agc cgc 575 Phe Gln Asn Val His Gln Gln Pro Leu Leu Asp Met Lys Ser Ser Arg 180 185 190 atc cgt tct gca aaa ccg caa act aca gta ttt cga gga atg att gga 623 Ile Arg Ser Ala Lys Pro Gln Thr Thr Val Phe Arg Gly Met Ile Gly 195 200 205 cat agc atg gtt aac agt aaa ata ctt ctc tta aag aaa cca aga gtc 671 His Ser Met Val Asn Ser Lys Ile Leu Leu Leu Lys Lys Pro Arg Val 210215 220 tgg tgg gag cta gaa ggc cca caa gta cct ctg cga cct gac tgc ctt 719 Trp Trp Glu Leu Glu Gly Pro Gln Val Pro Leu Arg Pro Asp Cys Leu 225 230 235 gct atc gtc aat aat ttt gtg ttc ctg ttac gaa gag ctg ggc 767 Ala Ile Val Asn Asn Phe Val Phe Leu Leu Gly Gly Glu Glu Leu Gly 240 245 250 255 ccg gat ggt gaa ttc cat gct tct tcc aaa gta ttc agg tat gac ccg 815 Pro Asp Gly Glu Phe Ala His He Ser Lys Val Phe Arg Tyr Asp Pro 260 265 270 aga cag aac tcc tgg ctg cag atg gca gat atg tct gta cca cgc tct 863 Arg Gln Asn Ser Trp Leu Gln Met Ala Asp Met Ser Val Pro Arg Ser 275 280 285 285 gaa ttt gct gta ggt gtt att ggg aag ttt att tac gcc gta gca ggc 911 Glu Phe Ala Val Gly Val Ile Gly Lys Phe Ile Tyr Ala Val Ala Gly 290 295 300 aga acc aga gat gag act ttc tat tca act gag aga tat gac atc acc 959 Arg Thr Arg Asp Glu Thr Phe Tyr Ser Thr Glu Arg Tyr Asp Ile Thr 305 310 315 aac gat aaa tgg gaa ttt gtg gat cct tat cca gtt aac aaa tat gga 1007 Asn Asp Lys Trp Glu Phe Val Asp Pro Tyr Pro Val Asn Lys Tyr Gly 320 325 330 335 cat gag ggg aca gtg ctc aat aac aaa ttg ttt atc acc ggt gga atc 1055 His Glu Gly Thr Val Leu Asn Asn Lys Leu Phe Ile Thr Gly Gly Ile 340 345 350 350 acc tca tct tcc acc tcc aag caa gtg tgc gtg ttt gac ccc agc aaa 1103 Thr Ser Ser Ser Thr Ser Lys Gln Val Cys Val Phe Asp Pro Ser Lys 355 360 365 gaa ggg acc ata gaa caa cgg acc agg aga act caa gtg gtt acc aac 1151 Glu Gly Thr Ile Glu Gln Arg Thr Arg Arg Thr Gln Val Val Thr Asn 370 375 380 tgt tgg gag aat aag agc aag atg aat tac gcg aga tgc ttt cac aag 1199 Cys Trp Glu Asn Lys Ser Lys Met Asn Tyr Ala Arg Cys Phe His Lys 385 390 395 atg att tct tac aat ggc aag ctt tat gtc ttc ggt ggt gtc tgt gtg 1247 Met Ile Ser Tyr Asn Gly Lys Leu Tyr Val Phe Gly Gly Val Cys Val 400 405 410 415 atc ttg agg gcc tct ttc gaa tct cag gct aca gaa gta 1295 Ile Leu Arg Ala Ser Phe Glu Ser Gln Gly Cys Pro Ser Thr Glu Val 420 425 430 tac aac cca gag act gat cag tgg acc atc ttg gca tcc atg ccg att 1343 Tyr Asn Pro Glu Thr Asp Gln Trp Thr Ile Leu Ala Ser Met Pro Ile 435 440 445 ggt aga agt ggc cat ggt gtg act gtg ctg gac aaa caa ata atg gtt 1391 Gly Arg Ser Gly His Gly Val Thr Val Leu Asp Lys Gln Ile Met Val 450 455 460 ctt gga ggc ctt tgt tat aat ggt cat tac agc gat tcc atc ctc act 1439 Leu Gly Gly Leu Cys Tyr Asn Gly His Tyr Ser Asp Ser Ile Leu Thr 465 470 475 ttt gat ccg gat gaa aac aag tgg aag gaa gat gag tac cct cgg atg 1 Phe Asp Pro Asp Glu Asn Lys Trp Lys Glu Asp Glu Tyr Pro Arg Met 480 485 490 495 ccc tgc aag ctg gat ggt tta caa gta tgc aac ctg cat ttt ccg gac 1535 Pro Cys Lys Leu Asp Gly Leu Gln Val Cys Asn Leu Phe Pro Asp 500 505 510 tat gta ctg gat gag gtc agg cgt tgc aac taatgacatc ctcctcccta 1585 Tyr Val Leu Asp Glu Val Arg Arg Cys Asn 515 520 aaaaaagagg caaacaaagt atttgtttgc acagagtaat taattaaaac atataaagaa 1645 aaacctcacc agttttacta tcaaagccat tggtctaaca ttgtaagaat ttttcattct 1705 gtgctagcat cctttttttc ttttcagtgg cctcaaactc atgcaataag ttaattctaa 1765 gtgctagctc ttgaaactac ttccagaagc agttgaatag aatgctccac ttatctggga 1825 tattgatttt ctgctttaaa catttctttc agatgttagc gtaggagtca tgtgtcttct 1885 aagagaagac ccgataagtg tcactggatg tgatttcagt ctctgtctct atctgaaacc 1945 tttttgaaga tttatttcag tgtatttcag tctgttatac tttttagttt tattatttaa 2005 aagtttaaaa ctcttgacct ttttgcatgg ctttttgctg aaaatgcaaa aatataaatt 2065 ttctacaaaa ttaacttttt atattcaaaa cactatttct aagctgcctt ctcttatccg 2125 cattgtgtta gtgaaagcat attcatactc gcatacaacc tataaataca caaggcacat 2185 cccttttatg cgtggttagg attctatatt tttaagctag tgcacttact tgcacacaca 2245 gttcgccata cttgttgaat tttagatgta acgtcttttc acatattaac atttttagaa 2305 agttgaaata actggagtcc tcatttgcta tcaaagtagc ctatcttcag tccatactga 2365 ttcagtaata tttgaactcc ttatatttct gaaacatgta tggttatgaa aactaacacc 2425 ttatatttta ttttcaaaag taaatgttag tgttctttgt cgatgtatgt cttttctttt 2485 tgaaaatgtt tttctttgca gtctgtttaa cgttaccctg tttttagtga gaatcggagt 2545 ggtatatgac aagttctggc cctgcagcat gcaagcactt ttaaagagca tttaggtaat 2605 accagactcc taaatcaagg ccccttaaaa gtaagtgcaa ctcc catttt ttacattcag 2665 taaggctgct gcatttgtta ttgaatggaa ggtagaaact cttagaaaat ttgacctcag 2725 ttttgactta gaggtaagaa atagaattat aatgttactg gttttatcta cttgtttatt 2785 ttgtacaaaa tacccagcga cactagggat gtaagccctc agtttttgtt ttatttactg 2845 aaagctatta gcatgaagga tagtaaccac aaagttcaga atggatcaag aatagctgtt 2905 taaaagcatt tataataagt gttttaggat tagctgcacc tttcaactct ttaaatgcag 2965 aggaaaaaac atagttgaca aagttaagca agaataacct gggagtggat cattgaaatt 3025 gatgccattt gcgcatgagt agtctatatc tgatacagac tagatctata ctggcaaaac 3085 ttgccagatc ttagaatatt ggtgcaatat tgcaatgcct tctatatggc tgctgatgta 3145 taaattttct agtttcactt tgtttggtgt tttttgtttt tttgtttgtt tgtttgtttt 3205 tttgctgctg ccaccattga acataaaatg gaagtgtgaa gtcatggaaa tgtgaagact 3265 ttggtttttg ggggtttttt gggcagttat tagacatact atgagattaa acctgatctt 3325 caaactccag aattggaggc atttgggttt aagaaaccag gtacataagt agcttttgaa 3385 aaaaccattg gcattgattt caaaaatcaa taataatctt attttatata tgagacttat 3445 attttcatta actagtcctg tcatttactt acagtttcca aacatgaaa t ttggtatctt 3505 gtttcccatg gtaatatggg taaaagtctt tttctacatt taaaaaatac attattttat 3565 ttttgaaagt taggaataag ttagccattt aatttttttc tacattagtt tagtggcttt 3625 gtatgtgtgc tattttgctt taaagaaaat aacgtcttca ttattttcct cattgatgtc 3685 ttttgctaga aaagaccaag aaagagccat caggccaggt atccacatca aagcctttac 3745 actatagtgg tggttctctt taattgctta gatatgactt catgacccta gtcagggtga 3805 catctgggca aacatttgag tattcttggt cttccatttt aaagacagag gccaagatca 3865 aagttcatgt tttgtaaaat tcgtaaaatc ttaacttgaa ctaactctgg gttcagcttt 3925 acgtaagtca cgtcggacct gatgttagct gtaatcagtt ttgagcttta aggatagttg 3985 ctgttgcttg ggttctgaat gtatgagaaa actccctgtt tatatgtagt tctaatttag 4045 gttattttaa atccatgatt aacttacatt cccttttaaa attatggttt tattgctgca 4105 agagatttat ttttgttata ctaaactatg gaaaagtttt tcatagcatt tttttcaagt 4165 ttattttttg tgtgcttcat ttggagtttt tgtttatata cattgcgctc aaaaaagtag 4225 ttttttgaaa aattcagtaa gatttgaatc tatacagttt aactgttatg acctttatgc 4285 gtgttgtttt cactttatat ctcaaatgcc agagttcaca aaaatagctg atct tcatta 4345 attacatctt aattagaacc atttgttctc ttccgtgtct ttgaccttct aagttttgat 4405 tttaaagaaa ttccttgcac tacagccttt tcttaaaatg caagattctc actttgaagg 4465 ttttgtgttg gaagaaatgc tactggtttt taaaaagcaa agcttaacta atagaattat 4525 tagcttttct tgagacagct ttctgtgtcc tcattactct gctctgtgtg agtgttacta 4585 gaatttgtga aatactgact gagcccttca cttatctttt ctaaagcagc acctttggac 4645 acctcattct gggaagcctg ctcgagtcat agtaaaggac acacgcttta tgtggggaga 4705 agtggtaaaa atggagtttt gtcttaatta catgaaacta agctttaaaa tattttataa 4765 cagattattt gagctgcata atctaaacat gtcaaacgtt cagtgggact atttttatat 4825 atgtatatgt gggtgtaggt cataacattt cagtttataa tataaattgt tatttcagtt 4885 tataagctat ctctcagagg agactagctc ttttgagaat tcataattta aagttttaga 4945 ctgaagtaaa atgcaacata gataatagtg taaatcagat ataattgagg gctatatggc 5005 agtaaaactg ctagtgccag ttttcttgtt tgcctgttat acatttttga tttttgtttt 5065 tgtattctga acattttgag agatcatatg tttgttcaat tacatttaga gttggtttgg 5125 gaataaatat cttctaaaaa gagatttatc ttaaaaatgg aagtcctaaa aattagttt a 5185 tccagagttt ataaagtcaa atattcagta ggcatagact ggaatagata aattcatgga 5245 aatcatatcc tttcagtaca ccgtataact tcaatattac acaagtaaca ttgaggagaa 5305 tgccatcagc tttgttctcc cttaaattct ttggttttct ttttacattt tgggaacaac 5365 tgcatttaaa atgttattag tcagtatata gtaaggatta ggtgtttgct ttctgaagga 5425 atggtccagt gaggtgattg ggagaggtta ttttctacct aacttgtata tgccctatac 5485 ctcttgggca tactttgtct atagaaaaat attttgacct ttaggtacat tttgggccag 5545 tagtcaaata atcctagggc cgatataaaa atcttagaat aatttaaggt ttgcctttta 5605 tacctgtttt gaaagccttt acatttttgt caggtaattt ttcccaagcc gtggatataa 5665 tctattcaaa catgtttatg ctatccattc tgtttttttaaa ttgaaaaaaa tgttaaaagt 5725 gtttatgaag aaaagtttaa ataaaatatt tttaatcttt 5765 <210> 67 <211> 5768 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (830) .. (4297) <400> 67 tcactgttct ggagagaaac aaatgcatac tcacagcata aggcagtcct cgacacccat 60 gcctctgagt ggtcccataa ttatgagtgg aatacattct tatacattgt gactttcttg 120 aaatgtttat atgcagcatg acgaagttgc cccttttgca cttccctgac tccagcggac 180 gtctagccct gcatcattgt tcttgttttt atgtcccagt tgaccttggc attttgtttt 240 atcactttcc tggttgaagc caaaaaacaa agggtactac tttcttcttt ctttccatat 300 gtaccatact ttaggggaga gaggggccag tgtttggaca ctgttgattt aaaaaatctt 360 attttcagga tcataattac ggagcccctc ctcctccgac acctcctgct tctccccctg 420 tccagacgat catccctcgt tctgacctga atggcctgcc gtcgcctgta gaggaacgct 480 gtggagacag cccgaactct gaaggagaaa ctgtacctac ctggtgtcct tgtggtcttt 540 ctcaggatgg cttccttctc aactgtgaca agtgcaggta agatcctgtt ccatctaaat 600 ttaagtctgg gttgctggga ttagggtttc ttacaagtag ggaaaagctc aaagtattct 660 ttcttgtgtt tgttaatgta gatgattcct tagtgctcct tggctcgaat tctctgcact 720 aggtgagaat tgctgacaac aaggaatgag agattgatgt taaagctatt gaatttgata 780 tgaaatttaa tgtcctggaa acatttggta ggtgggaggg agggggtag cat atg cag 838 His Met Gln 1 aga cac ttc gcc cat gtg tgc tat gat gtg atg cat gct gtt gga agg 886 Arg His Phe Ala His Val Cys Tyr Asp Val Met His Ala Val Gly Arg 5 10 15 act act tta agt tta ttt tcc ctc ttt agg gga atg agc agg ggg aag 934 Thr Thr Leu Ser Leu Phe Ser Leu Phe Arg Gly Met Ser Arg Gly Lys 20 25 30 35 gtt att aga ctt cat cgg cgg aag cag gac aac ata tca ggt ggg gat 982 Val Ile Arg Leu His Arg Arg Lys Gln Asp Asn Ile Ser Gly Gly Asp 40 45 50 agc agt gca aca gaa agc tgg gat gag gag ctt tct cct tcc act gtg 1030 Ser Ser Ala Thr Glu Ser Trp Asp Glu Glu Leu Ser Pro Ser Thr Val 55 60 65 ttg tat aca gca aca cag cac aca cct aca agc atc acc tta act gtt 1078 Leu Tyr Thr Ala Thr Gln His Thr Pro Thr Ser Ile Thr Leu Thr Val 70 75 80 aga aga acc aaa ccc aag aag cgg aaa aag agt cca gaa aag ggt cgt 1126 Arg Arg Thr Lys Pro Lys Lys Arg Lys Lys Ser Pro Glu Lys Gly Arg 85 90 95 gca gca cca aag acg aag aaa atc aag aat tct ccc tct gaa gca cag 1174 Ala Ala Pro Lys Thr Lys Lys Ile Lys Asn Ser Pro Ser Glu Ala Gln 100 105 110 1 15 aat tta gat gag aat aca act gag ggc tgg gaa aat cgg ata aga cta 1222 Asn Leu Asp Glu Asn Thr Thr Glu Gly Trp Glu Asn Arg Ile Arg Leu 120 125 130 tgg act gac cag tat gaa gaa gct ttc act aat cag tac agt gca gat 1270 Trp Thr Asp Gln Tyr Glu Glu Ala Phe Thr Asn Gln Tyr Ser Ala Asp 135 140 145 gta cag aac gcg ctt gaa caa cac cta cat tct agc aag gaa ttt gtg 1318 Val Gln Asn Ala Leu Glu Gln His Leu His Ser Ser Lys Glu Phe Val 150 155 160 ggc aaa cct act att tta gac act att aat aag act gaa ttg gcc tgt 1366 Gly Lys Pro Thr Ile Leu Asp Thr Ile Asn Lys Thr Glu Leu Ala Cys 165 170 175 aat aac aca gtt att ggt tcc caa atg cag tta cag ctg gga aga gtc 1414 Asn Asn Thr Val Ile Gly Ser Gln Met Gln Leu Gln Leu Gly Arg Val 180 185 190 195 act cgt gtt caa aag cac cgg aag atc ctg agg gct gca aga gat ttg 1462 Thr Arg Val Gln Lys His Arg Lys Ile Leu Arg Ala Ala Arg Asp Leu 200 205 210 gct ttg gac act ctt ata ata gag tat cgt ggg aaa gtc atg tta cga 1510 Ala Leu Asp Thr Leu Ile Ile Glu Tyr Arg Gly Lys Val M et Leu Arg 215 220 225 cag caa ttt gag gtc aat ggg cat ttc ttc aaa aaa cca tac ccc ttt 1558 Gln Gln Phe Glu Val Asn Gly His Phe Phe Lys Lys Pro Tyr Pro Phe 230 235 240 gtg ctc ttc tac tca aaa ttcat ggt gta gag atg tgt gtg gat gcc 1606 Val Leu Phe Tyr Ser Lys Phe Asn Gly Val Glu Met Cys Val Asp Ala 245 250 255 cgt act ttc ggt aat gat gct cgg ttc atc aga aga aga tca tgt aca cca 1654 Arg Thr Phe Gly Asn Asp Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro 260 265 270 275 aat gca gag gtg cga cac atg att gca gat ggg atg att cac ctg tgc 1702 Asn Ala Glu Val Arg His Met Ile Ala Asp Gly Met Ile His Leu Cys 280 285 290 atc tat gct gtg tct gcc atc acc aag gat gct gag gtc acc ata gca 1750 Ile Tyr Ala Val Ser Ala Ile Thr Lys Asp Ala Glu Val Thr Ile Ala 295 300 305 ttt gat tat gag tat agt aac tgt aat tat aaa gtg gac tgt gcc tgt 1798 Phe Asp Tyr Glu Tyr Ser Asn Cys Asn Tyr Lys Val Asp Cys Ala Cys 310 315 320 cac aag gga aac cgg aat tgt cct ata caa aaa agg aat cct aat gct 1846 His Lys Gly Asn Arg Asn Cys Pro I le Gln Lys Arg Asn Pro Asn Ala 325 330 335 aca gaa ctg cca ctc cta cca cct cct cca agc cta ccc acc att gga 1894 Thr Glu Leu Pro Leu Leu Pro Pro Pro Pro Ser Leu Pro Thr Ile Gly 340 345 345 350 355 gca gag act aga cgt aga aaa gca cga cgg aaa gag cta gag atg gag 1942 Ala Glu Thr Arg Arg Arg Lys Ala Arg Arg Lys Glu Leu Glu Met Glu 360 365 370 cag cag aat gag gct tca gag gag aat aat gac cag caa tca caagaa 1990 Gln Gln Asn Glu Ala Ser Glu Glu Asn Asn Asp Gln Gln Ser Gln Glu 375 380 gtt cca gaa aaa gta act gta tcc agt gat cat gag gaa gta gac aat 2038 Val Pro Glu Lys Val Thr Val Ser Ser Asp His Glu Glu Val Asp Asn 390 395 400 cca gaa gaa aaa cca gaa gaa gag aaa gaa gag gtt ata gat gac cag 2086 Pro Glu Glu Lys Pro Glu Glu Glu Lys Glu Glu Val Ile Asp Asp Gln 405 410 415 gag aac cta gct cat agc agg acc agg gaa gat aga aag gta gaa 2134 Glu Asn Leu Ala His Ser Arg Arg Thr Arg Glu Asp Arg Lys Val Glu 420 425 430 435 gcc atc atg cat gct ttt gaa aac tta gag aaa aga aag aag cgg cgg 2182 Ala Ile Me t His Ala Phe Glu Asn Leu Glu Lys Arg Lys Lys Arg Arg 440 445 450 gat cag ccc ttg gaa cag agc aac tct gat gta gag att act aca acc 2230 Asp Gln Pro Leu Glu Gln Ser Asn Ser Asp Val Glu Ile Thr Thr Thr Thr 455 460 465 acc tca gag act cct gtt ggt gaa gag aca aaa act gaa gcc cct gaa 2278 Thr Ser Glu Thr Pro Val Gly Glu Glu Thr Lys Thr Glu Ala Pro Glu 470 475 480 tct gaa gtt agc aac tct gtt tca aat gtt acc atc cca agc acc cca 2326 Ser Glu Val Ser Asn Ser Val Ser Asn Val Thr Ile Pro Ser Thr Pro 485 490 495 cag agt gtt ggt gtg aat acc cgg agg tct tcc caa gca ggg gat att 2374 Gln Ser Val Gly Val Asn Thr Arg Arg Ser Ser Gln Ala Gly Asp Ile 500 505 510 515 gct gca gaa aaa cta gtc ccc aag cca cct cca gca aag cct tct agg 2422 Ala Ala Glu Lys Leu Val Pro Lys Pro Pro Pro Ala Lys Pro Ser Arg 520 525 530 530 ccc cgg ccg aag agt cga att tct cgg tac agg acc agt tca gcc caa 2470 Pro Arg Pro Lys Ser Arg Ile Ser Arg Tyr Arg Thr Ser Ser Ala Gln 535 540 545 aga cta aag cgt cag aag cag gcc aat gca cag cag gca gaa ttg tca 2518 Arg Leu Lys Arg Gln Lys Gln Ala Asn Ala Gln Gln Ala Glu Leu Ser 550 555 560 caa gct gcc ttg gaa gag gga gga agt aac agt tta gta act cct act 2566 Gln Ala Ala Leu Glu Glu Gly Gly Ser Asn Ser Le Val Thr Pro Thr 565 570 575 gaa gct gga agt cta gac agt tca gga gaa aac agg cca tta aca ggg 2614 Glu Ala Gly Ser Leu Asp Ser Ser Gly Glu Asn Arg Pro Leu Thr Gly 580 585 590 595 595 tct gac cca act gtg gtg tca att act gga tcc cat gtc aac cgt gct 2662 Ser Asp Pro Thr Val Val Ser Ile Thr Gly Ser His Val Asn Arg Ala 600 605 610 gca tct aaa tac ccc aaa acc aaa aag tat cta gtt aca gaa tgg ttg 2710 Ala Ser Lys Tyr Pro Lys Thr Lys Lys Tyr Leu Val Thr Glu Trp Leu 615 620 625 aat gac aaa gca gag aag caa gag tgc cct gtt gag tgc cct tta cgt 2758 Asn Asp Lys Ala Glu Lys Gln Glu Cys Pro Val Glu Cys Pro Leu Arg 630 635 640 atc aca acg gat cca act gta ctg gca acg acc cta aac atg tta cca 2806 Ile Thr Thr Asp Pro Thr Val Leu Ala Thr Thr Leu Asn Met Leu Pro 645 650 655 ggt ctt atc cat tcc ccg tta att tgc acc acc ccc aaa cac tac att 2854 Gly Leu Ile His Ser Pro Leu Ile Cys Thr Thr Pro Lys His Tyr Ile 660 665 670 675 cgc ttt ggc tca ccc ttt atc cct gag aga cgt cga agg ccc ctt ctg 2902 Arg Phe Gly Ser Pro Phe Ile Pro Glu Arg Arg Arg Arg Pro Leu Leu 680 685 690 cct gat ggc aca ttc agc tcc tgt aag aag cgc tgg ata aaa caa gcc 2950 Pro Asp Gly Thr Phe Ser Ser Cys Lys Lys Arg Trp Ile Lys Gln Ala 695 700 705tta gaa gaa ggg atg act caa aca tca tct gta ccc caa gag act aga 2998 Leu Glu Glu Gly Met Thr Gln Thr Ser Ser Val Pro Gln Glu Thr Arg 710 715 720 act cag cac cta tac caa agc aat gag aat agt agc tct tct agt atc 3046 Thr Gln His Leu Tyr Gln Ser Asn Glu Asn Ser Ser Ser Ser Ser Ile 725 730 735 tgc aaa gac aat gca gac ttg ttg agc cca tta aag aaa tgg aag tct 3094 Cys Lys Asp Asn Ala Asp Leu Leu Ser Pro Leu Lys Lys Trp Lys Ser 740 745 750 755 cgc tat ctg atg gag cag aat gtc acc aag tta ctt cgg cct ctg tct 3142 Arg Tyr Leu Met Glu Gln Asn Val Thr Lys Leu Leu Arg Pro Leu Ser 760 765 770 cca gtc aca cca ccc cct ccc aat tca ggc tca aag agt ccc cag ctg 3190 Pro Val Thr Pro Pro Pro Pro Asn Ser Gly Ser Lys Ser Pro Gln Leu 775 780 785 gcc aca cct ggc tca tct cac cca gga gaa gag gag tgt cga aat gga 3238 Ala Thr Pro Gly Ser Ser His Pro Gly Glu Glu Glu Cys Arg Asn Gly 790 795 800 tac agc ctc atg ttt tca cca gtc aca tct ctt act act gct agt cgc 3286 Tyr Ser Leu Met Phe Ser Pro Val Thr Ser Leu Thr Thr Ala Ser Arg 805 810 815 tgc aac act cct cta cag ttt gag ctt tgt cac cga aaa gac ctg gat 3334 Cys Asn Thr Pro Leu Gln Phe Glu Leu Cys His Arg Lys Asp Leu Asp 820 825 830 835 ttg gca aaa gta gga tac ctt gac aac act aac agc tgt gct gat 3382 Leu Ala Lys Val Gly Tyr Leu Asp Ser Asn Thr Asn Ser Cys Ala Asp 840 845 850 aga cct tcc cta ctc aac tca ggt cat tct gac ctg gct cct cat ccc 3430 Arg Pro Ser Leu Leu Asn Ser Gly His Ser Asp Leu Ala Pro His Pro 855 860 865 tcc ctc gga ccc act tct gag act ggt ttc cca agc aga agt gga gat 3478 Ser Leu Gly Pro Thr Ser Glu Thr Gly Phe Pro Ser Arg Ser Gly Asp 870 875 8 80 gga cat cag acc ctc gtg aga aac tca gac cag gca ttt cgg aca gag 3526 Gly His Gln Thr Leu Val Arg Asn Ser Asp Gln Ala Phe Arg Thr Glu 885 890 895 ttc aac ttg atg tat gcc tac tcc cct ttg aat gct atg cct cga gca 3574 Phe Asn Leu Met Tyr Ala Tyr Ser Pro Leu Asn Ala Met Pro Arg Ala 900 905 910 915 gat gga ctg tat cga gga tct cct cta gtg ggg gat agg aag cct tta 3622 Asp Gly Leu Tyr Arg Gly Ser Pro Leu Val Gly Asp Arg Lys Pro Leu 920 925 930 cat ttg gat ggg gga tat tgt tcc cct gca gaa gga ttt tcc agc aga 3670 His Leu Asp Gly Gly Tly Cys Ser Pro Ala Glu Gly Phe Ser Ser Arg 935 940 945 tat tat gaa cat ggc tta atg aaa gac ctc tct cgt gga tcc ttg tca cct 3718 Tyr Glu His Gly Leu Met Lys Asp Leu Ser Arg Gly Ser Leu Ser Pro 950 955 960 ggt ggt gaa agg gcc tgt gaa gga gtc cca tct gcc ccc cag aly cca 3 Gly Glu Arg Ala Cys Glu Gly Val Pro Ser Ala Pro Gln Asn Pro 965 970 975 cca cag agg aaa aaa gta tcc ctg ctg gag tac cga aaa cgg aaa caa 3814 Pro Gln Arg Lys Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys A rg Lys Gln 980 985 990 995 gaa gct aag gaa aat tct gct ggt ggg gga ggt gac tct gca cag agc 3862 Glu Ala Lys Glu Asn Ser Ala Gly Gly Gly Gly Asp Ser Ala Gln Ser 1000 1005 1010 aaa agc aag tct gca gga ggg caa ggc agc agt aac tcc gtt tcc 3910 Lys Ser Lys Ser Ala Gly Ala Gly Gln Gly Ser Ser Asn Ser Val Ser 1015 1020 1025 gac act ggt gcc cat ggt gtg cag gga tcc tca gcc cga act cca tct 3958 Asp Thr Gly Ala His Gly Val Gln Gly Ser Ser Ala Arg Thr Pro Ser 1030 1035 1040 tcc cct cac aaa aaa ttc tcc cca tct cat tcc tct atg tcc cat ttg 4006 Ser Pro His Lys Lys Phe Ser Pro Ser His Ser Ser Met Ser His Leu 1045 1050 1055 gag gcg gta agc cca tca gat tcc aga ggc act tct tca tct cac tgc 4054 Glu Ala Val Ser Pro Ser Asp Ser Arg Gly Thr Ser Ser Ser His Cys 1060 1065 1070 1075 aga cct caa gag aat atc agc agt agg tgg atg gtt ccc aca tca gta 4102 Arg Pro Gln Glu Asn Ile Ser Ser Arg Trp Met Val Pro Thr Ser Val 1080 1085 1090 gaa cga ctc cga gaa gga ggg agc atc ccc aag gtc ctc cga agc agc 4150 Glu Arg Leu Arg Glu Gly Gly Ser Ile Pro Lys Val Leu Arg Ser Ser 1095 1100 1105 gtg agg gtg gcc caa aag gga gag ccc tct ccc aca tgg gag agt aac 4198 Val Arg Val Ala Gln Lys Gly Glu Pro Ser Pro Thr Trp Glu Ser Asn 1110 1115 1120 atc aca gag aaa gac tca ggt gag ccc atg gcc ttc tgc tgc cac cac 4246 Ile Thr Glu Lys Asp Ser Gly Glu Pro Met Ala Phe Cys Cys His His 1125 1130 1135 att cag gga cac atg agc cga gtc ctg tac tgc cta gtg ctg 4294 Ile Gln Gly His Met Ser Arg Val Leu Tyr Ser Ser Cys Leu Val Leu 1140 1145 1150 1155 agt tgaggtgagt cagtttctga tgcagttggg ctccaccgca tgctaggttc 4347 Ser cagcccactt atgctcattt gggctaccac atttgtaaga tctagcattg cttgctctct 4407 gtctgctctt ttttccccaa ggaatacctt tctgtaactc tcatctctcc aaagtcctgg 4467 aaatctacct cgatgaagga tgaagagaaa gaagacggga atcacatcag gcatttagaa 4527 catagcccat aattaaccac tcattttgcc cttctggcat gctgcactca cccaatttgt 4587 cacaaagaga gcagtacggg ttggtgatgg cactggtgat ttaaatgaaa aatggctcttttatctta tttactta tttacttatttacttatttacttattacctattg gaccct 4707 gcagatggag aaggcccaga gacattaagc tcagcactct ctaaaggagc aacagtttac 4767 agcccttcca gatacagcta ccagctcctg cagtgtgata gtcctcggac agaatcacaa 4827 agcctccttc agcagagttc ctcccccttc agaggacatc ctacacagtc tccaggatac 4887 agttatcgaa ctactgcact gagacctgga aaccccccct ctcacggttc ttcagaatca 4947 tccctctctt ccacgtccta ttccagcccc gcccaccctg tgtccacaga ctcgttggcc 5007 ccatttacgg ggacaccagg gtattttagc agccagccac attctggaaa cagcactggc 5067 agcaatcttc caaggaggag ctgcccttct agtgctgcta gccctaccct gcagggaccc 5127 tcagactcgc caacctcaga ttcagtttct cagtccagca caggaactct gagttccacc 5187 tcctttcctc agaactctag gtcgtcattg ccatcagact tacggactat cagtctgccc 5247 agtgctgggc agtcagctgt ctaccaggcc tccagggtat ctgcggtttc caattcacag 5307 cactacccac accgtgggag tgggggtgtg caccagtacc gactccagcc actgcaaggg 5367 tcaggagtca agactcagac gggactttcc tagggcttct ggatttgggc aaacagaact 5427 gaatgagccc atagctgctt ccttccagct gcctctggaa cctaggccga gcatattgct 5487 gaggaacggg gggtacaagg tgccagagga ttgggtctgg tggacaagaa acaagacttg 5547 tggtcacaat tggcctctgg ccttggagaa agctgtaaat cttgtctgaa gcagagacta 5607 taaagaagtt tctccctgct gtcaagggta cattgttgac aagcaaatgg tgtttcggtt 5667 agtaacggtt ctaagtgcg tgagtgc tgagtgc tgagtgc tgagtgc tgagtgc tgagtgc tgagtgcg <210> 68 <211> 5477 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1195) .. (3846) <400> 68 ccgggcaata ttagaccatc aacagtttga ctacataata aggatgatga attgtactct 60 acaggattgt tcaagtttag aagaatacaa cattgccgca gcattactcc ctttgaccag 120 tgctttctat aggaaacttg cccctggagt cagccagttt gcttacacgt gtgtacaaga 180 ccaccccatt tggacaaatc agcaattttg ggagacaacc ttttacaatg cagtgcagga 240 acaggttcgc tccctttatc tctcagccaa ggaagacaat catgccccgc atctgaagca 300 aaaggataag cttcctgatg accattatca ggagaagaca gcaatggacc tggcagctga 360 gcaactacgc ctttggccta ccctgagcaa gtcaactcag caagagctag tgcaacatga 420 ggaaagcact gtctttagtc aggccattca ctttgcaaac ctcatggtga acctgctagt 480 tccactcgac acaagtaaaa acaagctcct aagaacatca gcgccaggtg actgggagag 540 cggaagcaac agcattgtca caaacagtat tgcaggaagt gtagctgaga gctatgatac 600 agagagtggg tttgaagatt cagagaatac tgacattgcc aattctgttg tgcggttcat 660 tacccgattt attgacaaag tttgtacaga gagtggagtt actcaggatc acatcaagag 720 ccttcattgc atgataccag gaattgtagc tatgcacatt gagaccctag aagcagtaca 780 tcgagaaagc agaagacttc cgcctattca gaagcccaag attcttagac ctgctctgct 840 gccaggagaa g aaattgtct gtgagggtct tcgagtcttg ctggatcctg atggaagaga 900 agaagctact ggaggtcttc ttggaggccc tcagctcctg ccagcagaag gagccttgtt 960 cctcaccaca tacagaattc tcttcagagg aacaccccat gatcagttag tgggtgagca 1020 gacagttgtg cggagctttc ccattgcctc catcaccaag gagaagaaga ttacaatgca 1080 gaaccagcta cagcagaaca tgcaagaagg actgcagatc acatcagcat cttttcagtt 1140 gattaaggta gcatttgatg aagaagtcag tccagaagta gtagagatct ttaa gaa 1197 Glu 1 aca gct gat gaa gtt ccg tta tcc tca gtc cat ttt cag tac ctt tgc 1245 Thr Ala Asp Glu Val Pro Leu Ser Ser Val His Phe Gln Tyr Leu Cys 5 10 15 ttt tgc tgc tgg aca aac tac ccc aca aat aat ttt acc aaa aca gaa 1293 Phe Cys Cys Trp Thr Asn Tyr Pro Thr Asn Asn Phe Thr Lys Thr Glu 20 25 30 gga aaa gaa cac ttc ttt tcg tac ctt ctc aaa aac aat tgt gaa agg 1341 Gly Lys Glu His Phe Phe Ser Tyr Leu Leu Lys Asn Asn Cys Glu Arg 35 40 45 tgc caa aag ggc agg gaa aat gac aat tgg gcg gca ata tta ctg aag 1389 Cys Gln Lys Gly Arg Glu Asn Asp Asn Trp Ala Ala Ile Leu Leu Lys 50 55 60 65 aag aag aca g gg aca att gtg gaa gaa aga gta aat cgt cct gga tgg 1437 Lys Lys Thr Gly Thr Ile Val Glu Glu Arg Val Asn Arg Pro Gly Trp 70 75 80 aat gaa aat gat gat gta tct gtt tca gat gag agt gag ctc ccc aca 1485 Asn Glu Asn Asp Asp Val Ser Val Ser Asp Glu Ser Glu Leu Pro Thr 85 90 95 agt acc acc ctg aag gcc tcc gag aag tct aca atg gaa cag ttg gtg 1533 Ser Thr Thr Lele Lys Ala Ser Glu Lys Ser Thr Met Glu Gln Leu Val 100 105 110 gaa aaa gct tgt ttc aga gac tat cag cgt tta ggt tta gga acc ata 1581 Glu Lys Ala Cys Phe Arg Asp Tyr Gln Arg Leu Gly Leu Gly Thr Ile 115 120 125 agt ggc agc tct tcc cgt tca aga ccc gag tat ttt aga att act gcc 1629 Ser Gly Ser Ser Ser Arg Ser Arg Pro Glu Tyr Phe Arg Ile Thr Ala 130 135 140 145 tcc aac agg atg tat tca ctc tgc cgg agc tat cct ggc ctt tta gtc 1677 Ser Asn Arg Met Tyr Ser Leu Cys Arg Ser Tyr Pro Gly Leu Leu Val 150 155 160 gta cct caa gct gta cag gac agt agt tta cca aga gta gct cgc tgc 1725 Val Pro Gln Ala Val Gln Asp Ser Ser Leu Pro Arg Val Ala Arg Cys 165 170 175 tat cga cac aat cgc ctg cct gtt gta tgt tgg aag aac tca aga agt 1773 Tyr Arg His Asn Arg Leu Pro Val Val Cys Trp Lys Asn Ser Arg Ser 180 185 190 ggt act ctg ctc ctc cga tct gga gga ttc cat ggg aag gga gtc gtt 1821 Gly Thr Leu Leu Leu Arg Ser Gly Gly Phe His Gly Lys Gly Val Val 195 200 205 ggt ctt ttc aaa tct cag aac tcc cct cag gcc gct cct acc tcc tct 1869 Gly Leu Phe Lys Ser Gln Asn Ser Pro Gln Ala Ala Pro Thr Ser Ser 210 215 220 225 tta gaa tct tcc agt agc ata gaa caa gag aaa tac ttg caa gcc tta 1917 Leu Glu Ser Ser Ser Ser Ile Glu Gln Glu Lys Tyr Leu Gln Ala Leu 230 235 240 ctg aat gct gtt tct gtc cat cag aaa ctc aga ggc aac agc act ctt 1965 Leu Asn Ala Val Ser Val His Gln Lys Leu Arg Gly Asn Ser Thr Leu 245 250 255 act gtc agg cca gcc ttt gct cta tct cca ggg act gaa agg agg act 2013 Thr Val Arg Pro Ala Phe Ala Leu Ser Pro Gly Thr Glu Arg Arg Thr 260 265 270 tca aga atg tcc act gtg ctt aag cag gta gtg cca gga cat ttg gat 2061 Ser Arg Met Ser Thr Val Leu Lys Gln Val Val Pro Gly His Leu Asp 275 280 285 gta aac cca tcc aat agc ttt gct caa gga ggt gtg tgg gca agt ctt 2109 Val Asn Pro Ser Asn Ser Phe Ala Gln Gly Gly Val Trp Ala Ser Leu 290 295 300 305 cgc tct agc act cgc ttg atc ag tct cca aca tcc ttc att gat gtt 2157 Arg Ser Ser Thr Arg Leu Ile Ser Ser Pro Thr Ser Phe Ile Asp Val 310 315 320 ggc gcc cgg ctg gca ggc aag gat cac tcg gcc tcc ttc agt aac agc 2205 Gly Ala Arg Leu Ala Gly Lys Asp His Ser Ala Ser Phe Ser Asn Ser 325 330 335 agc tac cta caa aac cag ctc ttg aaa cgg caa gca gcc ctt tac ata 2253 Ser Tyr Leu Gln Asn Gln Leu Leu Lys Arg Gln Ala Ala Leu Tyr Ile 340 345 350 ttt ggt gaa aag tcg caa cta agg aac ttc aag gta gaa ttt gct tta 2301 Phe Gly Glu Lys Ser Gln Leu Arg Asn Phe Lys Val Glu Phe Ala Leu 355 360 365 aat tgt gag ttt gtt cct gtt gaa tc cat gaa atc gtg aaa 2349 Asn Cys Glu Phe Val Pro Val Glu Phe His Glu Ile Arg Gln Val Lys 370 375 380 385 gcc agt ttt aag aag ctg atg agg gct tgt atc cca agc acc atc cct 2397 Ala Ser Phe Lys Lys Leu Met Arg A la Cys Ile Pro Ser Thr Ile Pro 390 395 400 act gac tca gaa gtg acc ttc ctg aaa gcg ctg gga gat tct gag tgg 2445 Thr Asp Ser Glu Val Thr Phe Leu Lys Ala Leu Gly Asp Ser Glu Trp 405 410 415 ttc cca cag ctt cac agg ata atg cag ctg gct gtg gtt gta tca gaa 2493 Phe Pro Gln Leu His Arg Ile Met Gln Leu Ala Val Val Val Ser Glu 420 425 430 gta ctt gag aat ggt tcc tca gtt ttg gtc tgt ttg gag gaa ggc Val Leu Glu Asn Gly Ser Ser Val Leu Val Cys Leu Glu Glu Gly Trp 435 440 445 gac atc act gca caa gtg aca tcc ctg gtt cag tta ctc agt gat ccc 2589 Asp Ile Throra Ala Gln Val Thr Ser Leu Val Gln Leu Leu Ser Asp Pro 450 455 460 465 ttt tat agg aca ctt gaa ggc ttc cag atg ttg gtt gaa aaa gag tgg 2637 Phe Tyr Arg Thr Leu Glu Gly Phe Gln Met Leu Val Glu Lys Glu Trp 470 475 480 480 ctc tct ttt ggt cacaaa cag agg agc agc ttg acc ctc aac 2685 Leu Ser Phe Gly His Lys Phe Ser Gln Arg Ser Ser Leu Thr Leu Asn 485 490 495 tgt cag ggg agt ggt ttt gct cca gtc ttc tta cag ttc tta gac tgt 2733 Cys Gln Gly Se r Gly Phe Ala Pro Val Phe Leu Gln Phe Leu Asp Cys 500 505 510 gta cac cag gtt cac aac cag tat cca act gag ttt gaa ttc aat ctc 2781 Val His Gln Val His Asn Gln Tyr Pro Thr Glu Phe Glu Phe Asn Leu 515 520 525 tat tac tta aag ttc ttg gct ttc cac tat gtg tct aat cgc ttt aaa 2829 Tyr Tyr Leu Lys Phe Leu Ala Phe His Tyr Val Ser Asn Arg Phe Lys 530 535 540 545 aca ttt ctc ctg gat tga gac tat gag cac gga act tta 2877 Thr Phe Leu Leu Asp Ser Asp Tyr Glu Arg Leu Glu His Gly Thr Leu 550 555 560 ttt gat gat aaa gga gaa aag cat gcc aaa aaa gga gtc tgt att tgg 2925 Phe Asp Asp Lys Gly Glu Lys His Ala Lys Lys Gly Val Cys Ile Trp 565 570 575 gaa tgt att gac aga atg cac aag agg agt ccc att ttc ttt aat tat 2973 Glu Cys Ile Asp Arg Met His Lys Arg Ser Pro Ile Phe Phe Asn Tyr 580 585 590 590 tta tat t cca ttg gaa ata gag gct cta aag ccc aat gta aac gtc 3021 Leu Tyr Ser Pro Leu Glu Ile Glu Ala Leu Lys Pro Asn Val Asn Val 595 600 605 tct agc ctc aag aag tgg gat tac tac ata gaa gag acc ctg tcc aca 3069 Ser Ser Leu Lys Lys Trp Asp Tyr Tyr Ile Glu Glu Thr Leu Ser Thr 610 615 620 625 ggc cct tcc tat gac tgg atg atg cta acc ccc aag cac ttc ccc tcc 3117 Gly Pro Ser Tyr Asp Trp Met Met Leu Thr Pro Lys His Phe Pro Ser 630 635 640 gaa gac tct gac ctg gct gga gaa gct ggg cca cgg agc cag agg aga 3165 Glu Asp Ser Asp Leu Ala Gly Glu Ala Gly Pro Arg Ser Gln Arg Arg 645 650 655 655 aca gtg tgg cca tgc tat gat gtc agc tgt act cag cct gat gct 3213 Thr Val Trp Pro Cys Tyr Asp Asp Val Ser Cys Thr Gln Pro Asp Ala 660 665 670 ctc acc agc ctt ttc agt gaa att gaa aaa ttg gag cac aaa ttg aac 3261 Leu Thr Leu Seru Phe Ser Glu Ile Glu Lys Leu Glu His Lys Leu Asn 675 680 685 caa gcc cct gag aag tgg cag cag ctg tgg gaa agg gta acc gtg gac 3309 Gln Ala Pro Glu Lys Trp Gln Gln Leu Trp Glu Arg Val Thr Val Asp 690 695 700 705 ctt aaa gaa gaa cca aga aca gat cgc tcc caa aga cac ctg tcg aga 3357 Leu Lys Glu Glu Pro Arg Thr Asp Arg Ser Gln Arg His Leu Ser Arg 710 715 720 tcc cca gga att gtg tct acc aac cta cct tcc tat cag aag agg tct 3405 Ser Pro Gly Ile Val Ser Thr Asn Leu Pro Ser Tyr Gln Lys Arg Ser 725 730 735 ctg cta cat ctc cca gac agc agc atg ggg gag gaa cag aat tcc agc 3453 Leu Leu His Leu Pro Asp Ser Ser Met Gly Glu Glu Gln Asn Ser Ser 740 745 750 atc tcc cca tcc aat gga gtg gag cga aga gca gcc acg ctc tat agc 3501 Ile Ser Pro Ser Asn Gly Val Glu Arg Arg Ala Ala Thr Leu Tyr Ser 755 760 760 765 cag tat aca tcc aag aat gat gaa aac agg tcc ttt gag gga aca ctt 3549 Gln Tyr Thr Ser Lys Asn Asp Glu Asn Arg Ser Phe Glu Gly Thr Leu 770 775 780 780 785 tat aaa aga ggg gct ttg ctg aaa ggt tgg aag ccc cgt tgg gtt 3597 Tyr Lys Arg Gly Ala Leu Leu Lys Gly Trp Lys Pro Arg Trp Phe Val 790 795 800 ttg gat gta aca aaa cat cag ctg cgc tac tat gac tca ggt gag gac 3645 Leu Asp Val Thr Lys His Gln Leu Arg Tyr Tyr Asp Ser Gly Glu Asp 805 810 815 aca agc tgt aaa ggc cac att gat ctg gct gaa gta gaa atg gtc atc 3693 Thr Ser Cys Lys Gly His Ile Asp Leu Ala Glu Val Glu Met Val Ile 820 825 830 cct gc ggc ccc ag tg gga gcc cca aag cac aca agt gac aag gct 3741 Pro Ala Gly Pro Ser Met Gly Ala Pro Lys His Thr Ser Asp Lys Ala 835 840 845 ttc ttt gat ctc aag acc agc aaa cgt gtg tat aac ttc tgc gcc cag 3789 Phe Asp Leu Lys Thr Ser Lys Arg Val Tyr Asn Phe Cys Ala Gln 850 855 860 865 gat gga cag agt gcc cag caa tgg atg gac aag atc cag agt tgt atc 3837 Asp Gly Gln Ser Ala Gln Gln Trp Met Asp Lys Ile Gln Ser Cys Ile 870 875 880 tct gat gcc tgatgcccat ggtcaaccca cgcagaagaa acagaagaac 3886 Ser Asp Ala tcatgctgcc agatagatag aaaaagaagc atggatcctt gaggagctga caacaagtta 3946 tcccagggcc tgaggttctc ctgcccagtc ccctcttgca ggggttgcta tatctactta 4006 acctgaatag gtgtttcaca caggtctggt caacagcccc atgcactccc tgtatcttgc 4066 actaaatttt tctaacaggg tcttagtggt taatgatcag aagatgtctc ctgagccaac 4126 tgtgaacctc acccaggcaa aatggctacc acctacttgg gtccttcttc atgaaagcta 4186 tagatccttt tttgttctct gaggtcataa tttcctcgga gacctgttta acaagcaaaa 4246 atcaaaaccc tccaagattg tctcatattc tacctggact aggtttccta tgagagacat 4306 ctacttgtaa t gcctgacct ttgagatgct cagttctctg gtgctgccaa aagatgtttc 4366 catggtccgt gctctgccag tggggttcac aacaagagac gtcattgttc agtagcaggc 4426 aaagagggag cacacagcat tattctgatg gaaaaagatt atccagggaa tggtacaaca 4486 atgaccagcc caatgcagga aaacactact tccaaaacac tgaattctct agaccagagg 4546 tgctctgagg atccagggcc ttgtgttctt atgtatcttc tgcttcctga cagcttcttt 4606 ttcaaaataa catgcaaaaa aagctgaatg cactaactca caaaacaaac acttgcactg 4666 aattcccaat gaagtgaaga tgttggaaag acagaggcca gctatttagg accatacgca 4726 cctgtgacaa gggctgtgtt gaccacagtc acactgtggc atgactggat acccaaacta 4786 cacttctaca catgaaaagt aagaactgtc tttagatttt ctttactttg ataacttgtg 4846 attgtttagc ttaagaccca agaaatgctg tttgctcatg gtaaacagaa acagcatctt 4906 cgctacaacc actgacacca gctggcgtca taggtagcta gatcattgca tttgttttga 4966 aatgttaata tgttaaatac taaactaata tttcaaaaat gtgtatatat gatttctata 5026 tccttgtttt tcagatagcc tgcttataat ttaatataaa ttaactgatg cattcataag 5086 atttcaataa tgaaatggtt cccttttaaa aaataaaaat actttgtaga ttaaaaataa 5146 atcagaattt caaatt taaa attgtccaca cactaggaaa tagaactgtg ttaatatata 5206 agaaatttgg ggataattaa gaatgaagga cttttctatc atttccattt tataaattgc 5266 cacctgtgaa aatggttttt gcacattatt tgtatttttc tttgtatatg aaataatttt 5326 ttgtactttg taaaatatgg agcccattgt accttcaact atttgagact atacacagtg 5386 cttcttttgt aactggatta ctttaacttt cgtgaaggca ttacattgcc tcacattcac 5446 taaccacctt gaattaaatt tatttcttaa g 5477 <210> 69 <211> 5290 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (742) .. (1368) <400> 69 cccacacaga tgggatttgg gcataggttt ggtttcccag ggggcagtgc tgagctcttt 60 gccagtggga aatgggatgc tggtgatttc cagtaggtga cctcacagtg actcaagcta 120 ccacttactg ttgattgtga cgaaatgcca gctgaggcac atgccttggg agctaagtgg 180 ttgctgcact tgaccactgt gaagactggt gtgggaaggg tcgttttgga tgcacttgag 240 caggggtccc caaaccctga gccatggagc cacaaggaac cacacagcag gaggtgagtg 300 gtgtcgagtg agggagtgag ggaagcttcg tctgtattta cagccactcc cctttgctca 360 cattcccgcc tgagctccac cttctcagat cagcagcagc attagattct cataggagaa 420 cgcaccctgt tgtgaactgt gcatgtgaga gatctaggtt gcgctgtcct tatgagaatc 480 taatacctat tgatctgtca ctttctccca tcacgctcag gtgggaccat ccagttgcag 540 gaaaacaagc ttaagacgcc cactgattct acattatggt gagttctata attattttat 600 tatatattac agtgtaataa tggaaataaa gtgcctaata aatgcaaatg tgcttacatc 660 ttttggccca gctcctacct cccggcagcc tctccaggcc cagaactttc tccaatcagc 720 ctctacagac caagctcatg a ctc aca atg gcc tat tta ggc cca tac cct 771 Leu Thr Met Ala Tyr Leu Gly Pro Tyr Pro 1 5 10 acg tca cgg cag tct ccg cag atg agc cta ctg ccc cac aac agc ctc 819 Thr Ser Arg Gln Ser Pro Gln Met Ser Leu Leu Pro His Asn Ser Leu 15 20 25 cac agg cac agc tcc atc gtt aca atg gcc tct tta gac cca gct cct 867 His Arg His Ser Ser Ile Val Thr Met Ala Ser Leu Asp Pro Ala Pro 30 35 40 gcc tcc cag cct tct ctc cag gcc ctg aac ttt ctc aag tcg acc tca 915 Ala Ser Gln Pro Ser Leu Gln Ala Leu Asn Phe Leu Lys Ser Thr Ser 45 50 55 cca ggc cca gct cat gct tct ttg cag cct ctc cag gcc cag ctc ctg 963 Pro Gly Pro Ala His Ala Ser Leu Gln Pro Leu Gln Ala Gln Leu Leu 60 65 70 cat ctt ggt ggc ccc tcc agg ccc agc ctc tgc ccc ccg tct 1011 His Leu Gly Gly Pro Ser Arg Pro Ser Leu Cys Leu Pro Ser Ala Ser 75 80 85 90 aca gtc cca aca tct gcc tca cag cag att ctt cac gcc cag cat ctg 1059 Thr Val Pro Thr Ser Ala Ser Gln Gln Ile Leu His Ala Gln His Leu 95 100 105 cct cac tgt gga ccc ccc aag cca agc tcc caa cct ttc agc agc ttc 1107 Pro His Cys Gly Pro Pro Lys Pro Ser Ser Gln Pro Phe Ser Ser Phe 110 115 120 tac aca ccc agc tcc tgc cac cca gtg g cc tct tta ggc caa gct cat 1155 Tyr Thr Pro Ser Ser Cys His Pro Val Ala Ser Leu Gly Gln Ala His 125 130 135 gct tca caa ggg cct ttc cag gcc caa ctt ttg tct cat ggc aac ctt 1203 Ala Ser Gln Gly Pro Phe Gln Ala Gln Leu Leu Ser His Gly Asn Leu 140 145 150 ccc tgg cca gat tcc tgc ctg tct ccc agc agc cta gac agg ccc agg 1251 Pro Trp Pro Asp Ser Cys Leu Ser Pro Ser Ser Leu Asp Arg Pro Arg 155 160 165 170 tct tgc ctc aca ctg gcc tct cta cat gca gct tat gcc tca cgg tgg 1299 Ser Cys Leu Thr Leu Ala Ser Leu His Ala Ala Tyr Ala Ser Arg Trp 175 180 185 cct ctc cag gcc caa ctc ctg tcc cag gac gtc atc tcc ccc aaa 1347 Pro Leu Gln Ala Gln Leu Leu Ser Gln Asp Val Ile Ser Gly Pro Lys 190 195 200 act tac tca agt cag act ctg tagtcccaac tgctgcctcc tggtggccta 1398 Thr Tyr Ser Ser Gln Thr Leu 205 tgaaggccca aaatctcctccctcctccctccctccctccctccctccctccctccctccctccctccctccctccctcccgcc cgtcatgggg gcttctccag gcccacctct tcctcttggc 1518 tgggtctaca ggcacaactg ctgcctcaca acagcctttt ttggcccagt tcctgtccag 15 78 ctcatggcgg ccaatgtagg cccaaaactt cctcaagtca aactctccag gcccaccttc 1638 tgcttcccag tggcatgaac aggcccagct ttgacttgag aacagcctct gcaggccctg 1698 ctcttgcctc ccaggggctt tttccaggcc cagctcttgc ctcatggcag ctgccccagg 1758 ccaaatttct gcctgcctgc cagcagcctc aacaggcata gctcctccct cacagtggcc 1818 catttaggcc caactcatga ctgtcgggcc atttccaggc ctagtgcctg cctcgtggct 1878 gactcttgaa gcccaaaact tcctcaaatc agccttttgc ccaacttctg tctactgtcg 1938 gactctacag gccagcctct gcctcacagt ggaccctcca gacccagatg gtgtctcact 1998 gtggcatcct cagtcgaagc tcctgccttt cggcagcctc tccaggccca gctcctcctg 2058 cctcccagtg gcctctttcg gcccagccca gctcatgcct cccggcggcc ttcccaagcc 2118 ccgcttttga ctttcggtgg cctctgcagg cctcgacaag gcccagcctc ctgcctcccg 2178 aaggcctgca caggcccagc ctctgcctca cagcggactc tccacaccca gctagctgtc 2238 gcctcattgc ggcctcccga gtccaaagct cctgcctctc ggccgcttcg gcaggcccag 2298 ctcccacctg ccagtggcct cttcaggccc atggggctcg ttcctcacaa cggcctttcc 2358 aggcccagtt tttcccttcc ggcggcctct ccgggcccag aacctcctca agtcggcctc 2418 tc cagagcca cttgcaccct ccgggcgtcc tctccgggcc cagctcttct tcctggttgc 2478 gtctccaggc ccgactcctg cctctcaaca acctctttgg actcagtgcc tacccatctc 2538 ctggcggcat tggtcggccc acagcttcct caagccaagc tccccaggcc caggtcaggc 2598 ctcacggtgg cctctccagg atgagctcct gccctccgat ggcatctcca ggccccaaat 2658 ggtctccggt cggtgggctc ctccacgcca agcttgggcc tcccggcgac cgctgcaggc 2718 ccaagttgtc ctgaagtcgg cctctcctgg ccctgcctcc cagcaagtaa gcaagctctt 2778 ttggctcaac tcctgcccag ctcccaaccg cctttctagg ccccgaactt tctccagcca 2838 agctctgagg gcccacctcc tgcctcctgg tggcctgtac aggcccagca ctggttggag 2898 aacagcctct gcaggccccg cccttgccta ccaggggcct ctccaggcgc agctcttgcc 2958 cccacggcgg cctcccgggg ccaggtccct gcctgcctcc cagcagcccg cgtgcggccc 3018 agctcctctc tcacggtggc ctgttgatgc ccaccctccc acgcggacag aggtcagcct 3078 gagccccttg cctcacaccg gcccctccca cgcggacaga ggtcagcctg agccccttgc 3138 ctcacaccgg cccctcccgc gctgagagag gtcagtgtga gcccctgcct caacaggcca 3198 ccgtgaggga ggagcggggt cgcacgcggg ctgctgggag gtaggcaggg acttgggcct 3258 gggaggtc gc ggtggggcga gagctgggcc tggagactcc cctgggaggc aacagcgggg 3318 tctgcagaca cccttctcca gctggagctg ggactgttca gtcactggga gaagggatgt 3378 gggtctgaag agcttggttg cagaaacttc ggggtctaca agggccggcg ggagctgagc 3438 caaaagagct tgtttgctgg gaggcgggag atgcagccag gaggaacagc tgggccatgc 3498 gggaggcaga ggccgggcct cctcaagtcg gcctctcaga cccacttgca gcctcccagc 3558 gtcctctccg ggcccagctc ttcctcccgg ctgcgtctcc aggccggact ctggcccgac 3618 tccaggtccc aacaacgtct ttggactcag ctcctgccca gctcccagag gccctggtag 3678 gcccacaact tccctaagcc aagctcccca ggcccagctc aggcctcacg gtggcctctc 3738 caggctcagc tcctgccctc cgatggcatc tgcaggcccc aaacggcctc cggttggtgg 3798 gcttctctag gcccagcttg ggcctcccgg tggcctctgc aggcccaaat catcccgaag 3858 tcggcctctc caggcccagc tccggcctcc cggcggcctc tgcaggccca agtcgtcctc 3918 aagtcggcct ggaagtgggc ctggaagagc agcaagtcgg cctccccggg cccagctccg 3978 tcctctcggc ggcctctcca ggtgcaaaac ttcctcgagt cagcctctcc aggcccagct 4038 cttcctgcct cccagtggcc tctttcggcc cagcccagtt catggctctc ggcggccttc 4098 ccaggccccg ct tttgactt ttggcagcct cttcaggcgc agaacttgat ctccagtcgg 4158 cctttgcagg cccggcctcc tgcctctcaa aggcctgcac gggcccggcc ttggccttgg 4218 cctcacagtg gactctccac gcccagctag ctctcgcctc actgcggcct cccccgtcca 4278 aagctcctgc ctttcggcca cttcggcagg tccagctact ggctgccagt ggcctcttta 4338 ggccaagctc attcctcaca acggcctttc caggccccgt ttttcccttc cggcagcctc 4398 ttggcctcta atttgtttat cttttgtgta taaatcccaa aatatggaat tttggaatat 4458 ttccaccgtt atatattttg gtaggtaatt tatttggagt gagtttctgc accatgcccg 4518 aactttttgt tttattttcc ttattatttg gtgttaaaca ggtttaatga cggtcatggc 4578 aactttttgg cacaatgaaa aatatcgccc atgatcaacg tgttctgttc tggggaaggg 4638 ggcaaaggca gggtgaatca ctttcttaaa aagtatagct caagttggga gtgcagaggg 4698 aatggggaga aaacccttcc gctgcctgtg tcgaagtgca ggagccccca cccccatact 4758 cacctgagtc cagcccctct ggggaaagag ggggtgcatg aactcccctt ggtccacagg 4818 cgcctccctg tggcccaagg ccctcttcac actccatctt gtagccccag caggagctat 4878 tttccgaaaa gtgaaaagct ctgaaggtcc cacaattcat ggtatgtaca ggggctcgga 4938 ggagggaaac tgcccagc tt tcccccggca cagctgcagg ggtagggggt atagataaga 4998 ggagcaggcc ttggccaggc gtggtggctc acgcctgtaa tcccagcact ttgggagggg 5058 gaggcaggca gatcacgatg tcaggagatc gaaatcagcc tggccaagat gatgaagccc 5118 cgtctgtact aaaaatacaa aaattagccg gacgtggtag cgtgcacctg taatcctagc 5178 tacccggaag gctgaggcag gagaatggcg tgaacccggt gggaagagtt tgcagtgagc 5238 cgggatcgca ccactgcact ccagcctggg cgacagagca agactcggtc tc 5290 <210> 70 <211> 5710 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1813) .. (4824) <400> 70 ggcgacggac ggcgcgagct gcgagcccga cttgtcccgg gccccggagg acgcggcggg 60 ggccgcggcg gaggcggcga aaaaagagtt tgatgtggat actctcagta aatccgagct 120 gcggatgctc ctcagcgtga tggaagggga gctggaggcc agagaccttg tcatcgaggc 180 cctgcgggct cgcaggaagg aggtatttat ccaggaacgg tatgggagat ttaatctaaa 240 tgacccgttc ctggcactcc agagagacta tgaagcaggt gctggtgaca aagagaagaa 300 gccagtttgt accaaccccc tctccatcct tgaagcagtc atggcccact gcaagaaaat 360 gcaagaaagg atgtccgcac agctggctgc tgctgagagc agacaaaaga agctggaaat 420 ggagaagctt cagctacaag cccttgagca agagcacaag aagctggctg cccgccttga 480 ggaagagcgt ggcaagaaca agcaggtggt cctgatgctg gtcaaagagt gcaagcagct 540 ctcaggcaaa gtcatagagg aggcccagaa gctcgaagac gtaatggcca aactggaaga 600 ggaaaagaaa aagacgaatg aattagaaga ggaactctcc gctgagaaac gaagaagcac 660 agaaatggaa gctcagatgg aaaaacaact ctctgagttt gacactgagc gggaacagct 720 tcgtgccaag ctgaaccggg aagaagcaca caccactgac ctcaaagagg agatagacaa 780 gatgaggaaa atgattgagc aactgaaaag gggaagtgac agcaaaccaa gcctctctct 840 tccacggaag a caaaagata ggcgtttggt ttccatatct gtgggaacag aaggaactgt 900 gacaaggtct gttgcatgcc agacagacct agtgacagaa aatgctgacc acatgaaaaa 960 gttgccttta accatgcctg taaaaccttc cacagggagt cccctagttt ctgcaaatgc 1020 aaaagggagc gtgtgcacca gtgccaccat ggccagacca ggtattgaca ggcaggcttc 1080 ctatggtgac ttgattggcg cttctgtacc cgctttccca cctccaagtg caaacaaaat 1140 tgaggaaaat ggaccaagca ctggctcaac accagatcca accagtagca cacccccact 1200 tcccagtaac gctgcccctc ccaccgctca aacaccaggc atagctcctc agaactcgca 1260 agctccacct atgcacagtt tacattcacc atgtgccaac acctctttgc atccaggtct 1320 aaacccacga atccaagcag ctagatttag atttcagggc aatgctaacg acccagacca 1380 aaatggaaat actacccaaa gtcctccgtc aagagatgtc tcgcctacaa gtcgtgacaa 1440 cctagtggcc aaacaactag ctcggaatac tgtgacccaa gcactgtcaa gatttacaag 1500 ccctcaagca ggtgctccct caaggcctgg agtgccccca acaggggatg ttggcaccca 1560 ccctccagtt ggtcggacca gtttaaagac tcatggtgta gcacgagttg acagaggaaa 1620 tcctcctcct atccctccaa aaaagccagg gctctcccaa actccttctc caccacaccc 1680 ccaactcaag gttattat ag acagcagcag ggcctcgaac acaggggcca aagttgataa 1740 caaaactgtg gcttcgactc cttccagttt gccacaaggg aacagggtga tcaatgagga 1800 gaaccttcct aa gtc atc ctc ccc tca gct gcc acc aaa acc atc Agra Atl A t Atl A t Ag t Ag l A tr Atl A gcc Acc aaa Acc atc Ag tgc agg ctg tgc cgt ttc agc cct ggc cac gtc 1899 Phe Asn Cys Gly Thr Cys Arg Leu Cys Arg Phe Ser Pro Gly His Val 15 20 25 tca ggc tgg tca ccc tcc cta acc cct ttg cta atg agt ggt ggt cct 1947 Ser Trp Ser Pro Ser Leu Thr Pro Leu Leu Met Ser Gly Gly Pro 30 35 40 45 gcc ccc ctg gct ggc agg ccc acc ctt ctt cag caa gct gct gcc cag 1995 Ala Pro Leu Ala Gly Arg Pro Thr Leu Leu Gln Gln Ala Ala Ala Gln 50 55 60 gga aat gtc act tta tta tca atg ctg ctt aat gaa gaa gga ctg gac 2043 Gly Asn Val Thr Leu Leu Ser Met Leu Leu Asn Glu Glu Gly Leu Asp 65 70 75 att aat tac tcc tgt gaa gat ggc cat tct gcc ttg tat tct gct gct 2091 Ile Asn Tyr Ser Cys Glu Asp Gly His Ser Ala Leu Tyr Ser Ala Ala 80 85 90 aag aat gga cat aca gac tgt gtg a ga ttg ctg ctg agt gca gaa gcc 2139 Lys Asn Gly His Thr Asp Cys Val Arg Leu Leu Leu Ser Ala Glu Ala 95 100 105 caa gtc aat gct gct gat aaa aat ggc ttc aca ccc ttg tgt gct gca 2187 Gln Val Asn Ala Ala Asp Lys Asn Gly Phe Thr Pro Leu Cys Ala Ala 110 115 120 125 gct gct cag gga cat ttc gag tgt gta gaa tta tta att tca tat gat 2235 Ala Ala Gln Gly His Phe Glu Cys Val Glu Leu Leu Ile Ser Tyr Asp 130 135 140 gct aac att aat cat gct gct gat gga gga cag aca cct cta tac ctg 2283 Ala Asn Ile Asn His Ala Ala Asp Gly Gly Gly Gln Thr Pro Leu Tyr Leu 145 150 155 gcc tgt aaa aat gga aat aaa gaa tgt att aaa ctc ttg ttg gaa gct 2331 Ala Cys Lys Asn Gly Asn Lys Glu Cys Ile Lys Leu Leu Leu Glu Ala 160 165 170 gga acc aat cga agt gta aaa acc aca gat ggc tgg aca cca gtt cac 2379 Gly Thr Asn Arg Ser Val Lys Thr Thr Asp Gly Trp Thr Pro Val His 175 180 185 gca gct gtg gac act ggt aat gtg gac agc ctc aag ctt ctt atg tac 2427 Ala Ala Val Asp Thr Gly Asn Val Asp Ser Leu Lys Leu Leu Met Tyr 190 195 200 205 cat aga ata cca gct cat gga aat tct ttc aat gag gag gag tcc gag 2475 His Arg Ile Pro Ala His Gly Asn Ser Phe Asn Glu Glu Glu Ser Glu 210 215 220 tca agt gtc ttt gac ttg gat gga gga gaa gag agt cct gaa ggc ata 25 Ser Ser Val Phe Asp Leu Asp Gly Gly Glu Glu Ser Pro Glu Gly Ile 225 230 235 tcc aag cct gtt gtt cct gca gac ctc att aac cac gcc aac aga gaa 2571 Ser Lys Pro Val Val Pro Ala Asp Leu Ile Asn His Ala Asn Arg Glu 240 245 250 ggc tgg act gct gcc cac att gct gct tcc aaa ggt ttt aag aac tgc 2619 Gly Trp Thr Ala Ala His Ile Ala Ala Ser Lys Gly Phe Lys Asn Cys 255 260 265 cta gaa atc ttg tgt agg cac gga ggg ctt gag cca gaa agg aga gac 2667 Leu Glu Ile Leu Cys Arg His Gly Gly Leu Glu Pro Glu Arg Arg Asp 270 275 280 285 aag tgc aat cgg act gtg cat gat gtt gcc act gat gac tgc aag cat 2715 Lys Cys Asn Arg Thr Val His Asp Val Ala Thr Asp Asp Cys Lys His 290 295 300 ttg ctg gag aat ctg aat gct ctt aaa ata ccc tta agg att tca gtg 2763 Leu Leu Glu Asn Leu Asn Ala Leu Lys Ile Pro Leu Arg Ile Ser Val 305 310 315 ggt gag att gaa cca agc aac tat ggt tct gat gac ttg gaa tgt gaa 2811 Gly Glu Ile Glu Pro Ser Asn Tyr Gly Ser Asp Asp Leu Glu Cys Glu 320 325 330 aac aca ata tgt gct tta aat atc cgca aaa ca tca tgg gat gat 2859 Asn Thr Ile Cys Ala Leu Asn Ile Arg Lys Gln Thr Ser Trp Asp Asp 335 340 345 ttt tca aaa gca gtg agt caa gct ctg aca aat cat ttc cag gca atc 2907 Phe Ser Lys Ala Val Ser Gln Ala Leu Thr Asn His Phe Gln Ala Ile 350 355 360 365 tct tct gat gga tgg tgg agt ctg gaa gac gtg act tgc aat aac acc 2955 Ser Ser Asp Gly Trp Trp Ser Leu Glu Asp Val Thr Cys Asn Asn Thr 370 375 380 380 act gat tcc aac atc ggc ctc agt gca aga agc ata cga tcc atc acg 3003 Thr Asp Ser Asn Ile Gly Leu Ser Ala Arg Ser Ile Arg Ser Ile Thr 385 390 395 cta gga aat gtg ccg tgg tca gtg ggt cag agc ttc gccg cag Leu Gly Asn Val Pro Trp Ser Val Gly Gln Ser Phe Ala Gln Ser Pro 400 405 410 tgg gac ttt atg agg aag aat aag gca gag cac atc act gtg ctt ttg 3099 Trp Asp Phe Met Arg Lys Asn Lys Ala Glu His Ile Thr Val Leu Leu 415 420 425 tca ggt cct caa gaa ggc tgt ctc agt agt gtg act tat gcc tcc atg 3147 Ser Gly Pro Gln Glu Gly Cys Leu Ser Ser Val Thr Tyr Ala Ser Met 430 435 440 445 atc cct ctc cag atg atg cag aac tac ctc agg ctg gtt gag caa tat 3195 Ile Pro Leu Gln Met Met Gln Asn Tyr Leu Arg Leu Val Glu Gln Tyr 450 455 460 cat aat gtc att ttc cac ggc cca gaa gga agc ttg caa gac Asac ata243 Ile Phe His Gly Pro Glu Gly Ser Leu Gln Asp Tyr Ile 465 470 475 gta cat cag ctt gca ctc tgc ctg aag cac aga caa atg gct gca gga 3291 Val His Gln Leu Ala Leu Cys Leu Lys His Arg Gln Met Ala Ala Gly 480 485 490 ttc tcc tgt gaa ata gtg aga gct gaa gta gat gct ggt ttt tcc aag 3339 Phe Ser Cys Glu Ile Val Arg Ala Glu Val Asp Ala Gly Phe Ser Lys 495 500 505 gaa cag cta cta gac ctg ttc atg tgt ctg atc cca gtg 3387 Glu Gln Leu Leu Asp Leu Phe Ile Ser Ser Ala Cys Leu Ile Pro Val 510 515 520 525 aaa caa tct ccc agt aag aag aaa atc atc atc att tta gaa aat tta 3435 Lys Gln Ser Pro Ser Lys Lys Lys Ile Ile Ile Ile Leu Glu Asn Leu 530 535 540 gaa aaa tct tca ctg tcg gag tta ttg agg gac ttt ttg gca cct ctt 3483 Glu Lys Ser Ser Leu Ser Glu Leu Leu Arg Asp Phe Leu Ala 555 550 aat cgc agc act gaa agc ccc tgc act ttc caa aaa gga aat gga 3531 Glu Asn Arg Ser Thr Glu Ser Pro Cys Thr Phe Gln Lys Gly Asn Gly 560 565 570 570 ctg tcc gaa tgt tat tac ttt cat gag aac tgc tttgct acc 3579 Leu Ser Glu Cys Tyr Tyr Phe His Glu Asn Cys Phe Leu Met Gly Thr 575 580 585 atc gcc aag gcc tgt ctc cag ggc tcc gac ttg ctg gtg cag cag cat 3627 Ile Ala Lys Ala Cys Leu Gln Le Lyu Asp Leu Val Gln Gln His 590 595 600 605 ttc cgc tgg gtg cag ctg cgg tgg gat ggc gag ccc atg caa gga ctg 3675 Phe Arg Trp Val Gln Leu Arg Trp Asp Gly Glu Pro Met Gln Gly Leu 610 615 620 ctc cag agg ttc agg aaa gtt gtg aat aag ttc aaa ggt cag 3723 Leu Gln Arg Phe Leu Arg Arg Lys Val Val Asn Lys Phe Lys Gly Gln 625 630 635 gcg ccc tcc ccc tgc gat cct gtg tgc aag att gtc gac tgg gct ctg ro Ser Pro Cys Asp Pro Val Cys Lys Ile Val Asp Trp Ala Leu 640 645 650 tcc gtc tgg cgt cag ctt aac tcc tgc ctg gcc cgc ttg ggc aca cct 3819 Ser Val Trp Arg Gln Leu Asn Ser Cys Leu Ala Arg Leu Gly Thr Pro 655 660 665 gaa gca ctt ctt gga cca aaa tat ttc ctg tct tgt cct gta gtt cct 3867 Glu Ala Leu Leu Gly Pro Lys Tyr Phe Leu Ser Cys Pro Val Val Pro 670 675 680 680 685 ggg cat gcc caa gtg aca gtg aag tgg atg tct aag ctg tgg aat ggc 3915 Gly His Ala Gln Val Thr Val Lys Trp Met Ser Lys Leu Trp Asn Gly 690 695 700 gtc atc gca ccc aga gtt caa gaa gca ata ttg tca aga gcc tct gtg 3963 Val Ile Ala Pro Arg Val Gln Glu Ala Ile Leu Ser Arg Ala Ser Val 705 710 715 aaa aga caa cct ggc ttt ggg cag aca act gct aaa aga cac cct agc 4011 Lys Arg Gln Pro Gly Phe Gly Gln Thr Thr Ala Lys Arg His Pro Ser 720 725 730 caa gga cag cag gct gtg gtc aaa gct gct ctc agc atc ttg cta aat 4059 Gln Gly Gln Gln Ala Val Val Lys Ala Ala Leu Ser Ile Leu Leu Asn 735 740 745 aaa gct gta ctg cat ggc tgt ccc ctc ccc cc gca a gac cag 4107 Lys Ala Val Leu His Gly Cys Pro Leu Pro Arg Ala Glu Leu Asp Gln 750 755 760 765 cat aca gct gat ttc aaa gga gga agt ttc cct tta tcc ata gtt tcc 4155 His Thr Ala Asp Phe Lys Gly Gly Ser Phe Pro Leu Ser Ile Val Ser 770 775 780 agt tat aac act tgt aac aag aag aaa gga gag agt ggt gcc tgg aga 4203 Ser Tyr Asn Thr Cys Asn Lys Lys Lys Gly Glu Ser Gly Ala Trp Arg 785 790 795 aag gtg aac acc agt cct cgc agg aag tct ggc cgc ttc tct tta ccc 4251 Lys Val Asn Thr Ser Pro Arg Arg Lys Ser Gly Arg Phe Ser Leu Pro 800 805 810 acc tgg aat aag cca gac cta agc act gaa ggt atg aaa aat aag act 4299 Thr Trp Asn Lys Pro Asp Leu Ser Thr Glu Gly Met Lys Asn Lys Thr 815 820 825 ata tca cag ctg aat tgt aac agg aat gct tct ctg tca aaa caa aag 4347 Ile Ser Gln Leu Asn Cys Asn Arg Asn Ala Ser Leu Ser Lys Gln Lys 830 835 840 845 tct tta gag aat gat cta tca ctg acg ttg aat ttg gat cag aga ctc 4395 Ser Leu Glu Asn Asp Leu Ser Leu Thr Leu Asn Leu Asp Gln Arg Leu 850 855 860 tct ctg ggt tca gat gac ga gat ctt gtc aag gaa ctt cag agc 4443 Ser Leu Gly Ser Asp Asp Glu Ala Asp Leu Val Lys Glu Leu Gln Ser 865 870 875 atg tgc tcc agc aag tct gag tct gat atc agc aag att gct gat tcc 4491 Met Cys Ser Ser Glu Ser Asp Ile Ser Lys Ile Ala Asp Ser 880 885 890 agg gat gat tta agg atg ttt gat agt tct gga aac aac cct gta ctt 4539 Arg Asp Asp Leu Arg Met Phe Asp Ser Ser Gly Asn Asn Pro Val Leu 895 900 905 tca gca act att aat aat ctg aga atg cca gtg tca caa aag gag gtc 4587 Ser Ala Thr Ile Asn Asn Leu Arg Met Pro Val Ser Gln Lys Glu Val 910 915 920 925 agt cct ctc agc agc cat caa act act gaa tgc ac ac agt aaa tca 4635 Ser Pro Leu Ser Ser His Gln Thr Thr Glu Cys Ser Asn Ser Lys Ser 930 935 940 aag act gag ttg ggt gtt tca aga gtt aaa tct ttt ctt cct gtt cct 4683 Lys Thr Glu Leu Gly Val Ser Arg Val Lys Ser Phe Leu Pro Val Pro 945 950 955 aga agt aaa gtc acc cag tgt tcc cag aac acc aaa aga agc agc agc 4731 Arg Ser Lys Val Thr Gln Cys Ser Gln Asn Thr Lys Arg Ser Ser Ser 960 965 970 agc agt aat aca agg caa ata gaa atc aac aac aac tca aaa gaa gtg 4779 Ser Ser Asn Thr Arg Gln Ile Glu Ile Asn Asn Asn Ser Lys Glu Val 975 980 985 aat tgg aac tta cac aaa aat gaa cac cta gaa aaa cct aac aaa24 Trp Asn Leu His Lys Asn Glu His Leu Glu Lys Pro Asn Lys 990 995 1000 taggcctgcc tacaatattc tcattattaa cttcctctat ttcacacaga aaccaaggac 4884 aacaagatac aaataccttt aaattgataa aatgttttca ctgtaatata aattatgagt 4944 gcgggaccac tattcaattt ttttttgtaa agaatgtatt tataaccaac attttgttgc 5004 tttttttttt aattctgtag gattgaactt caataccagg aagttatgcc aacttttcaa 5064 gtagttttat aatagaaaaa ttgtaatagt tttaatcaag atgttcaggg gtattaaaac 5124 agaactgtgt actgtatatc tgtatatatg tatatatgta tgtatattta aggaagtcca 5184 gaaatcatac tgcatacatg ctacaaaaaa gtagcaaaaa agtacaaagt tggcttagat 5244 aacttgtacc attttaaatg gagatcataa ttttatgttc acttgatggg gaatgactag 5304 aatggggcaa taacaaatca tttctaaaca gttattttcc attaaaagcc atattaagta 5364 ttttgcttgt taaattctag ttttatgttt taaatctctt agtggttaca ttgccatttg 5424 gtagcatcat gtatata ttt atgcttataa gtttgcatta tgactcctgt aaaatatgaa 5484 attataatgc aataaaagtg ttatctttct tacaaaagtt ttgtacctaa gtggatatag 5544 ataactgcat aaatgaataa attcagaatt aactccttca atatttctag tagcacaact 5604 gataatattg atattttcta caaatgttac ttctaaaatt acagacaaaa ttacttacac 5664 aattcagtta agatgctttg acactgaata aaatattgat ttcatg 5710 <210> 71 <211> 5502 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2140) .. (3810) <400> 71 atcataatat ataatgaaat aattatacaa ctcagcataa tgtagaatca gtggaatccc 60 tgagcttgtt ttcctgcagt tagacggtcc catctgatgg gagacagtga cagatcatca 120 ggcattagag tctcataagg agcacacaac ctagattcct tgcatgtgca gttcacagta 180 gggatggagt tagagctctt atgagaatct aatgccaccg ctgatctgat gagaggtgga 240 gctcaggttg taatgcaagt gatggggagc ggctgtaaat acagatgaag cttcgcttgc 300 tcacctgcca ctcacttcct gctgtgtagc ctggttcccc acaggccacg gaccagtact 360 ctctattagt agacaatcct gtggaacctt tggaattctt aaaatgatat ttaggattaa 420 cattgatatt tcttcattaa ttaaagtcta aaagccattt aaaatttgat tttcttaacc 480 ttaatggaat ccctctttct agacaaaaac aatgagtgta tctaaaaatt aatgtacgta 540 atttcaaaga tgcttgaagc agattaagaa aatgtgaaag gattaatgca gtagtgtagt 600 gggtgttcaa tgttttgttc tcagttggcc tggggaaggg gagccagttg tgtttctgga 660 gcaaactccc taaatacctt ctgtgtgtcc tgcttcatgc ctcatgtgct atctctgtta 720 gtgaagttgg cagagaccct gaaatggtgg aattagagcc tcatgttcaa aaatcattat 780 acttctaact tgcatacgtt aatattattc atagaacaat acacacaacc ttagatatct 840 tcatagcgtt c caaaaaaca tgttttcagc ttttcagaag tggaggacca aactacttgc 900 ttgtcttctt aggcaacata aaggatctaa aggatacaag caagttcttt ttcccagata 960 ttgtcgccat aaattcagtt gattaaaaat ctgcttaaca atttcatctt tttcaatcaa 1020 atcctattcc cttaaagatg gttacacttt ttggttaatg ttacttaaat cagataatga 1080 tacacatatt attaacaata ataatgacca tttattgagt ttctgttaag gaccaggacc 1140 tgtgctatgt gctttattat attacctctt ttactaattt catagcccag ggaaatgtgt 1200 atggccatag tatgccaata tctgctccca aagttattgg ggagatctat ggaatattct 1260 tttaaaaatt caaatataaa atatcataga aagcatgaag tttgttcttt tatttccttt 1320 gtttgattac atcttcttat aggtatctaa aaaagtggca gatttaatcc ttgaaaaaca 1380 gcctgcttat gtaaaggaac ttgaaagagt tacctcattg cagacaggtc ttcaattagc 1440 tgctgttatc tgtacaaatg ggagaaggta ttgcttttga tgatattttg ttctttaagc 1500 tgaacaatat ttcaagaata actatggaat ctataattta taattgattt tttaaattat 1560 ggatgtggtt tctagaatat cattccttaa gtgaacatat atcatgatct aaagactaca 1620 ctaagagggt ttgtgggaaa tatctctaag tgtacttatg ggttttaaaa aattactatt 1680 tttatattat ttagacta gt gcttcacaaa ctgtttgtcg taaagcacct acttttttct 1740 ttctaaaatt tccaatctgt tacaggctgt gattttttaa aaatgcagta aaaacaaatt 1800 actaggcaaa tgaaataaag aaggaaagac ataatacagt cttaattttt tttaattatt 1860 agagtcacaa agaataatta ttctgtcagt ttttgcactg tgtttttaag cgcttattct 1920 cagtttctgt aattttttgt tatagaccac tagcaggttg tgaattggca ccaatcttct 1980 cgtggtgttc tgagtaatgc tggtttagac tggccattga gtacatttgt caaatagtag 2040 tttaaatcct tggttttaat agtaatccat ttcactgctt cattagttac ctaattgttc 2100 tgtgtggata gtattcttat tataataaaa aacttttaa cta ttt att gtt cac 2154 Leu Phe Ile Val His 1 5 ttt tgc aga cac ttg aat att gca aag gaa ggt ttt act caa gct agt 2202 Phe Cys Arg His Leu Asn Ile Ala Lys Glu Gly Phe Thr Gln Ala Ser 10 20 tta ggc ctt ctt gca aat caa agg aaa cgt cag ttg ctg att gga ctt 2250 Leu Gly Leu Leu Ala Asn Gln Arg Lys Arg Gln Leu Leu Ile Gly Leu 25 30 35 ctg aaa tct ctg aga act ata aaa aca ttcaa gat gta cgg 2298 Leu Lys Ser Leu Arg Thr Ile Lys Thr Leu Gln Arg Thr Asp Val Arg 40 45 50 tta agt gaa atg ctg gag gag gaa gat tat cca gga gct att cag ttg 2346 Leu Ser Glu Met Leu Glu Glu Glu Asp Tyr Pro Gly Ala Ile Gln Leu 55 60 65 tgc ctt gaa tgt caa aaa gct gcc agc act ttt aaa cat tac tgt 2394 Cys Leu Glu Cys Gln Lys Ala Ala Ser Thr Phe Lys His Tyr Ser Cys 70 75 80 85 ata agt gaa ctg aat tca aag ctg caa gat act ttg gaa cag att gag 2442 Ile Ser Glu Leu Asn Ser Lys Leu Gln Asp Thr Leu Glu Gln Ile Glu 90 95 100 gaa cag ctg gac gta gct ctt tcc aaa atc tgc aag aat ttt gac att 2490 Glu Gln Leu Asp Val Ala Leu Ser Lys Ile Cys Lys Asn Phe Asp Ile 105 110 115 aac cat tat acc aag gtt caa caa gct tat cga ctt ctt gga aaa aca 2538 Asn His Tyr Thr Lys Val Gln Gln Ala Tyr Arg Leu Leu Gly Lys Thr 120 125 130 cag aca gca atg gat caa ctt cat atg cac ttc acc caa gcc att cac 2586 Gln Thr Ala Met Asp Gln Leu His Met His Phe Thr Gln Ala Ile His 135 140 145 aac acc gtg ttt caa gtt gtt ctt ggt tat gtg gaa cta tgt gca gga 2634 Asn Thr Val Phe Gln Val Val Leu Gly Tyr Val Glu Leu Cys Ala Gly 150155 160 165 aac aca gac aca aaa ttc caa aag ctg caa tat aag gat ctc tgt aca 2682 Asn Thr Asp Thr Lys Phe Gln Lys Leu Gln Tyr Lys Asp Leu Cys Thr 170 175 180 cat gtt aca cca gac agc tat att cca tgc gca gac ctg tgc aaa 2730 His Val Thr Pro Asp Ser Tyr Ile Pro Cys Leu Ala Asp Leu Cys Lys 185 190 195 gca cta tgg gaa gtt atg ctc agc tat tat agg act atg gaa tgg cat 2778 Ala Leu Trp Glu Val Met Leu Ser Tyr Tyr Arg Thr Met Glu Trp His 200 205 210 gaa aag cat gac aat gag gat act gct tca gct tct gaa ggg agt aat 2826 Glu Lys His Asp Asn Glu Asp Thr Ala Ser Ala Ser Glu Gly Ser Asn 215 220 225 atg ata ggt act gaa gaa act aat ttt gat cgt ggc tac ata aaa aag 2874 Met Ile Gly Thr Glu Glu Thr Asn Phe Asp Arg Gly Tyr Ile Lys Lys 230 235 240 245 aaa tta ga ga cat gga ctt aca cga ata tgg cag gat gtt cag ctaaaa 2922 Lys Leu Glu His Gly Leu Thr Arg Ile Trp Gln Asp Val Gln Leu Lys 250 255 260 gta aaa acc tac ttg ctt gga act gat ttg tct ata ttc aaa tat gat 2970 Val Lys Thr Tyr Leu Leu Gly Thr Asp Leu Ser Ile Phe Lys Tyr Asp 265 270 275 gat ttc atc ttt gtt ttg gat ata atc agc agg ttg atg caa gtt gga 3018 Asp Phe Ile Phe Val Leu Asp Ile Ile Ser Arg Leu Met Gln Val Gly 280 285 285 290 gaa gat gat t aag tct gaa gtt tta cag gaa tct att aga 3066 Glu Glu Phe Cys Gly Ser Lys Ser Glu Val Leu Gln Glu Ser Ile Arg 295 300 305 aaa caa agt gtc aat tat ttc aag aat tac cat aga aca cgg ctc gat 3114 Lys Gln Val Asn Tyr Phe Lys Asn Tyr His Arg Thr Arg Leu Asp 310 315 320 325 gaa ctg aga atg ttc tta gag aat gag act tgg gaa ctt tgt cct gtt 3162 Glu Leu Arg Met Phe Leu Glu Asn Glu Thr Trp Glu Leu Cys Pro Val 330 335 340 aag tca aat ttc agc atc ttg caa ctt cat gaa ttt aaa ttc atg gaa 3210 Lys Ser Asn Phe Ser Ile Leu Gln Leu His Glu Phe Lys Phe Met Glu 345 350 355 cag tct cgc tcc cca tca gtt tcac a cag cca gtc tca act 3258 Gln Ser Arg Ser Pro Ser Val Ser Pro Ser Lys Gln Pro Val Ser Thr 360 365 370 tct tca aaa aca gtg acc ttg ttt gag cag tac tgt agt ggt ggg aat 3306 Ser Ser Lys Thr Val Thr L eu Phe Glu Gln Tyr Cys Ser Gly Gly Asn 375 380 385 cca ttt gaa att cag gcc aac cac aaa gat gaa gaa aca gaa gat gtc 3354 Pro Phe Glu Ile Gln Ala Asn His Lys Asp Glu Glu Thr Glu Asp Val 390 395 400 tta gct tct aat ggg tat gaa tct gat gaa caa gaa aag agt gcc tat 3402 Leu Ala Ser Asn Gly Tyr Glu Ser Asp Glu Gln Glu Lys Ser Ala Tyr 410 415 420 caa gag tat gac agt gac agt gat gtt cct gag gaact cga gac 3450 Gln Glu Tyr Asp Ser Asp Ser Asp Val Pro Glu Glu Leu Lys Arg Asp 425 430 435 tat gtg gat gag cag aca gga gat ggt cct gtg aaa agt gtt tct cgg 3498 Tyr Val Asp Glu Gln Thr Gly Asp Gly Pro Val Lys Ser Val Ser Arg 440 445 450 gaa act cta aaa agc agg aag aaa tca gat tac agt cta aat aaa gtg 3546 Glu Thr Leu Lys Ser Arg Lys Lys Lys Ser Asp Tyr Ser Leu Asn Lys Val 455 460 465 aat gca cct atc tta aca aat aca aca ttg aac gtc ata aga ctt gtt 3594 Asn Ala Pro Ile Leu Thr Asn Thr Thr Leu Asn Val Ile Arg Leu Val 470 475 480 485 gga aaa tat atg cag atg atg aac att ctt aag cca att gcc ttt gat 3642 Gl y Lys Tyr Met Gln Met Met Asn Ile Leu Lys Pro Ile Ala Phe Asp 490 495 500 gtt att cat ttc atg tct caa cta ttt gat tat tac ttg tat gca ata 3690 Val Ile His Phe Met Ser Gln Leu Phe Asp Tyr Tyr Leu Tyr Ala Ile 505 510 515 tat acc ttt ttt ggt cgg aat gat tca ttg gaa tca act gga ctc ggc 3738 Tyr Thr Phe Phe Gly Arg Asn Asp Ser Leu Glu Ser Thr Gly Leu Gly 520 525 530 ctt agt agt agt aga cta aga aca act cta aac aga ata caa gaa agc 3786 Leu Ser Ser Ser Arg Leu Arg Thr Thr Leu Asn Arg Ile Gln Glu Ser 535 540 545 ctt att gat cta gat atg ttt ata tgaagtccaa gaatgtacat aaactcatat 3840 Leu Ile Asp Leu Asp Met Pet cgttgcctgg catcagaata cctagaaagg taaattagta atgagaagat 3900 ttctaatgag tatatcatca gatgaaagta aaactgagaa atttgaagtc cgatgagttt 3960 tcccgaccac aaattagact gcatcactcc tgttgactac atggctgtgt aactgaatca 4020 gtggttctct cctggatggt gctgaagagc ctggcacacc ctgcttcctg ggaagtttca 4080 gctgatccta ctgccacact cacagcagca gaagaaagaa aggagaaggt gccaagtcca 4140 cacctcagtc acctagtggt ttt gacatct ggggatacgc tgtatgggtt ggcagaaaga 4200 gtggtagcca cggaatcctt ggtattcttg gctgaacagt ttgagttcct tcagccacat 4260 ctggatgctg tgatgcctgc agtcaaaaag ccctttcttc agcagttcta ttctcagaca 4320 gtctcaaccg ccagtgaact acggaaacca atttactgga ttgtagctgg taaagccctt 4380 gattatgaac agatgctgct tctcatggct aatgtgaaat gggatgtaaa agaaattatg 4440 tcacagcaca acatatatgt agatgcacta ttaaaggaat ttgagcagtt taacaggagg 4500 ctaaatgaag tttctaagag agttcgcata cccttgcctg tgtctaatat actttgggaa 4560 cattgtatac gattggctaa tcgaactatt gtagaaggat atgccaatgt caagaaatgc 4620 agtaatgagg gtcgtgccct gatgcaattg gattttcaac agtttttaat gaaacttgaa 4680 aaactaacag atattagacc cattcctgat aaagaatttg tagaaactta tattaaagct 4740 tattacctaa ctgagaatga catggaacgg tggatcaaag agcacaggga atattcaacg 4800 aagcagctga ccaatctggt gaatgtttgc ctgggatccc atatcaataa gaaagcaaga 4860 caaaaacttc tagcagctat agatgatata gacagaccta aaagataatg aacacagctc 4920 tctttcctca atggcattga tcctcactca acatatatga cctgaaagcc agttttttta 4980 tgcacttctg acaactatct gctaagaa aa ctttgtgcat gtttttttga ctggaaagtg 5040 gaaaatattg aaatgtgtgt ggtgttctca tgacttttat atgctgtggt ctcttcaact 5100 tttggtctca tttgttgtaa tctgaaatga tgttgccgcc ttgtcataac aatggttatg 5160 tgactacagt tatacatttt acagaagaat gtaccataag tatataatta gaagaacagt 5220 ggcttaatat atgtatggga agtttatgga aaatgaagtt ggcacttttc taccctctga 5280 gcttggttct taataagcat aatgtgaggg tgaatatgta gtatctccta attatgagca 5340 ctgcatgaga attaaaaaac acatgtaagt aaaatagttg aaaaatcagt atgttctctg 5400 tttttaaaat gtcaaagttt atgtcagggt taatttagtt ataacaaagt gatcataatg 5460 gtgaaattta ataaatatac tctagtatga tcagcctatg tg 5502 <210> 72 <211> 5670 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3908) <400> 72 ga gac cat gaa gac aca aga aac gct ctc cct cct aga caa gat gga 47 Asp His Glu Asp Thr Arg Asn Ala Leu Pro Pro Arg Gln Asp Gly 1 5 10 15 gaa gtc acc act ggc aag tat gct aca aat tta gca gaa tcc gtg ctg 95 Glu Val Thr Thr Gly Lys Tyr Ala Thr Asn Leu Ala Glu Ser Val Leu 20 25 30 cag gat gca ttt att aga tta tct caa tct cag tcc aca tta ccc cag 143 Gln Asp Ala Phe Ile Arg Leu Ser Gln Ser Gln Ser Thr Leu Pro Gln 35 40 45 gaa tct gca gtc agt gtt tct gta gga agt tct ctg ctt ccc agt tgc 191 Glu Ser Ala Val Ser Val Ser Val Gly Ser Ser Leu Leu Pro Ser Cys 50 55 60 tat tcc aca aaa gat aca gtg gtt tct cgg tca tgg aat gag ctc ccc 239 Tyr Ser Thr Lys Asp Thr Val Val Ser Arg Ser Trp Asn Glu Leu Pro 65 70 75 aaa atc gtc gtt gtt cag agt cca gat ggc agt gat gct gcc cca cag 287 Lys Ile Val Val Val Gln Ser Pro Asp Gly Ser Asp Ala Ala Pro Gln 80 85 90 95 cca ggc atc tcc tcc tgg cct gag atg gaa gtc tct gtt gaa acc tca 335 Pro Gly Ile Ser Ser Trp Pro Glu Met Glu Val Ser Val Glu Thr Ser 100 105 110 agc atc ctc tct gga gag aac tcc agc aga caa ccc cag agt gct cta 383 Ser Ile Leu Ser Gly Glu Asn Ser Ser Arg Gln Pro Gln Ser Ala Leu 115 120 125 gaa gtg gcg tta gct tgt gca gcc act gtg att gga act att tcc agt 431 Glu Val Ala Leu Ala Cys Ala Ala Thr Val Ile Gly Thr Ile Ser Ser 130 135 140 cca cag gcc aca gaa aga ctc aaa atg gag caa gtg gtc tcg aac ttt 479 Pro Gln Ala Thr Glu Arg Leu Lys Met Glu Gln Val Val Ser Asn Phe 145 150 155 ccc cca ggg agc agt ggt gca ctg caa act caa gca ccc caa gga ctc 527 Pro Pro Gly Ser Ser Gly Ala Leu Gln Thr Gln Ala Pro Gln Gly Leu 160 165 170 175 aag gaa cct tcc atc aat gag tac tcc ttt cca tct gct ttg tgt ggc 575 Lys Glu Pro Ser Ile Asn Glu Tyr Ser Phe Pro Ser Ala Leu Cys Gly 180 185 190 atg act cag gtg gcc agt gcc gtg gct gtc tgt ggt ctg ggt gaa aga Met Thr ln Val Ala Ser Ala Val Ala Val Cys Gly Leu Gly Glu Arg 195 200 205 gaa gag gtg aca tgc tca gtg gct cca agt ggt agc ctc ccg cct gca 671 Glu Glu Val Thr Cys Ser Val Ala Pro Ser Gly Ser Leu Pro Pro Ala 210 215 220 gct gag gct tct gaa gcc atg cct cca ctt tgt ggt tta gca agc atg 719 Ala Glu Ala Ser Glu Ala Met Pro Pro Leu Cys Gly Leu Ala Ser Met 225 230 235 gag ctt ggc aag gaa gcc att gcc gc gga ttg aag gag gct gct 767 Glu Leu Gly Lys Glu Ala Ile Ala Glu Gly Leu Leu Lys Glu Ala Ala 240 245 250 255 ctg gtt tta aca agg cct aat acc tac agc agc att gga gac ttt ctg 815 Leu Val Leu Thr Arg Pro Asn Thr Tyr Ser Ser Ile Gly Asp Phe Leu 260 265 270 gac tcc atg aac agg aga atc atg gaa act gct tca aag tct cag acc 863 Asp Ser Met Asn Arg Arg Ile Met Glu Thr Ala Ser Lys Ser Gln Thr 275 280 285 285 ctg tgc tca gaa aat gtc gtc agg aat gaa ctg gca cat acc ctg tcc 911 Leu Cys Ser Glu Asn Val Val Arg Asn Glu Leu Ala His Thr Leu Ser 290 295 300 aat gtt atc ctg agg cat tcc att gat gaa gtt cac cac aaa aat atg 959 Asn Val Ile Leu Arg His Ser Ile Asp Glu Val His His Lys Asn Met 305 310 315 ata atc gac ccc aat gac aac agg cat tca tct gaa att ctg gac acc 1007 Ile Ile Asp Pro Asn Asp Asn Arg His Ser Ser Glu Ile Le u Asp Thr 320 325 330 335 tta atg gaa agt aca aat caa ctg ctt tta gat gtg ata tgc ttc acg 1055 Leu Met Glu Ser Thr Asn Gln Leu Leu Leu Asp Val Ile Cys Phe Thr 340 345 350 ttc aag aag atg agt cat att gta cgg ctt ggt gaa tgt cct gct gtc 1103 Phe Lys Lys Met Ser His Ile Val Arg Leu Gly Glu Cys Pro Ala Val 355 360 365 ctt tct aag gag acc atc aga agg agg gag aca gaa cca agc tgc cag 1151 Leu Ser Lys Glu Thr Ile Arg Arg Arg Glu Thr Glu Pro Ser Cys Gln 370 375 380 cca tct gat ccg ggt gct agt caa gct tgg aca aaa gcc act gaa tcc 1199 Pro Ser Asp Pro Gly Ala Ser Gln Ala Trp Thr Lys Ala Thr Glu Ser 385 390 395 tcc agc agc tct cca ctt agc aat tca cac aac acg agt ctt gtc atc 1247 Ser Ser Ser Ser Pro Leu Ser Asn Ser His Asn Thr Ser Leu Val Ile 400 405 410 415 aac aat ctt gtg gat ggc atg tat tca aaa caa gac aag ggt gga gtg 1295 Asn Asn Leu Val Asp Gly Met Tyr Ser Lys Gln Asp Lys Gly Gly Val 420 425 430 agg cca ggc ctc ttc aag aac ccc acg ctg cag tca caa tta tca cgt 1343 Arg Pro Gly Leu Phe Lys Asn P ro Thr Leu Gln Ser Gln Leu Ser Arg 435 440 445 agt cac aga gtg ccc gat tct tca act gct aca aca tcc tcc aag gaa 1391 Ser His Arg Val Pro Asp Ser Ser Thr Ala Thr Thr Ser Ser Lys Glu 450 455 460 ata tat ctg aaa gga ata gca gga gag gat aca aaa agc cct cag cac 1439 Ile Tyr Leu Lys Gly Ile Ala Gly Glu Asp Thr Lys Ser Pro Gln His 465 470 475 agt gag aat gaa tgc aga gcc tct tcc gaa gga caa agg tcc 1487 Ser Glu Asn Glu Cys Arg Ala Ser Ser Glu Gly Gln Arg Ser Pro Thr 480 485 490 495 gtc agc cag tcc aga agt ggt tcc cag gag gct gag gag agt atc cac 1535 Val Ser Gln Ser Arg Ser Gly Ser Gln Glu Ala Glu Glu Ser Ile His 500 505 510 cca aac acc caa gaa aag tac aac tgt gcc aca tct cgc atc aac gaa 1583 Pro Asn Thr Gln Glu Lys Tyr Asn Cys Ala Thr Ser Arg Ile Asn Glu 515 520 525 gtt caa gtc aac ctg tcctt tta ggg gat gac ctg ctg ctt cct gct 1631 Val Gln Val Asn Leu Ser Leu Leu Gly Asp Asp Leu Leu Leu Pro Ala 530 535 540 caa tcc acg ctt caa aca aag cat cca gac atc tac tgc att aca gac 1679 Gln Ser Th r Leu Gln Thr Lys His Pro Asp Ile Tyr Cys Ile Thr Asp 545 550 555 ttt gcg gaa gaa tta gca gac acg gtc gtc tcc atg gca act gaa att 1727 Phe Ala Glu Glu Leu Ala Asp Thr Val Val Ser Met Ala Thr Glu Ile 560 565 570 575 gca gcg att tgc ctt gac aac tcc agt gga aaa caa ccc tgg ttt tgt 1775 Ala Ala Ile Cys Leu Asp Asn Ser Ser Gly Lys Gln Pro Trp Phe Cys 580 585 590 gca tgg aaa aga ggg agt gag tttg aca ccc aac gta ccc tgc 1823 Ala Trp Lys Arg Gly Ser Glu Phe Leu Met Thr Pro Asn Val Pro Cys 595 600 605 cga tcc ttg aag agg aag aaa gag agc cag ggg agc ggg acc gct gtg 1871 Arg Ser Leu Lys Arg Lys Glu Ser Gln Gly Ser Gly Thr Ala Val 610 615 620 agg aaa cac aag cct ccc cgg ctc agt gag atc aag agg aag acg gac 1919 Arg Lys His Lys Pro Pro Arg Leu Ser Glu Ile Lys Arg Lys Thr Asp 625 630 635 gag cac cct gag ctt aaa gaa aag ctg atg aac agg gtt gtg gat gag 1967 Glu His Pro Glu Leu Lys Glu Lys Leu Met Asn Arg Val Val Asp Glu 640 645 650 655 655 tcc atg aac ctt gaa gat gtc cca gat tct ttc aat ctt gcc aat 2015 Ser Met Asn Leu Glu Asp Val Pro Asp Ser Val Asn Leu Phe Ala Asn 660 665 670 gaa gtg gca gcc aag atc atg aac cta acg gag ttc tct atg gtg gac 2063 Glu Val Ala Ala Lys Ile Met Asn Leu Thr Glu Phe Ser Met Val Asp 675 680 685 ggc atg tgg cag gcg cag ggc tat ccc cgg aat cgg tta ctg agt ggc 2111 Gly Met Trp Gln Ala Gln Gly Tyr Pro Arg Asn Arg Leu Leu Ser Gly 690 695 700 gac agg tgg ag cc aag gcc tcc agc tgc gaa agc att cct gag 2159 Asp Arg Trp Ser Arg Leu Lys Ala Ser Ser Cys Glu Ser Ile Pro Glu 705 710 715 gaa gac tcc gag gcc agg gcc tat gtc aac agc ctg ggc tta atg ac ag acg Glu Ala Arg Ala Tyr Val Asn Ser Leu Gly Leu Met Ser 720 725 730 735 acg ctg agc cag ccg gtc agc agg gcc agc tct gtc tcc aag cag tcg 2255 Thr Leu Ser Gln Pro Val Ser Arg Ala Ser Ser Val Ser Lys Gln Ser 740 745 750 agc tgt gag agc atc acc gat gag ttt tcc agg ttc atg gtg aac cag 2303 Ser Cys Glu Ser Ile Thr Asp Glu Phe Ser Arg Phe Met Val Asn Gln 755 760 765 atg gaa aat gaa ggg aga gga ttt gag tta ctg ctg gat tac tat gct 2351 Met Glu Asn Glu Gly Arg Gly Phe Glu Leu Leu Leu Asp Tyr Tyr Ala 770 775 780 780 ggc aag aac gcc agc agc att ctg aac tca gcc atg caa cag gcg Tgc Asla Gly Ile Leu Asn Ser Ala Met Gln Gln Ala Cys 785 790 795 cgg aaa agt gac cac ctc agt gtg agg cct agc tgt ccc tct aag cag 2447 Arg Lys Ser Asp His Leu Ser Val Arg Pro Ser Cys Pro Ser Lys Gln 800 805 810 815 815 tcc agc aca gag agc atc act gag gag ttc tac agg tac atg ctg agg 2495 Ser Ser Thr Glu Ser Ile Thr Glu Glu Phe Tyr Arg Tyr Met Leu Arg 820 825 830 gac atc gaa aga gac agc aga gaa agt gcc tcc tcc agc agc 2543 Asp Ile Glu Arg Asp Ser Arg Glu Ser Ala Ser Ser Arg Arg Ser Ser 835 840 845 cag gat tgg aca gcc ggc ctg ctg tct cct tct ctg cga tcc cca gtg 2591 Gln Asp Trp Thr Ala Gly Leu Leu Ser Ser Leu Arg Ser Pro Val 850 855 860 tgc cac aga cag tcg tcc atg cca gac agc aga tcc cca tgc tcc agg 2639 Cys His Arg Gln Ser Ser Met Pro Asp Ser Arg Ser Pro Cys Ser Arg 865 870 875 ctg aca gtg aat g tg ccc atc aaa gcc aac tct tta gat ggc ttt gct 2687 Leu Thr Val Asn Val Pro Ile Lys Ala Asn Ser Leu Asp Gly Phe Ala 880 885 890 895 cag aac tgc cca caa gat ttc cta agc gtg cag ccg gc ag ag ag Gln Asn Cys Pro Gln Asp Phe Leu Ser Val Gln Pro Val Ser Ser Ala 900 905 910 tcc tca tcc ggt ctc tgc aaa tct gac tct tgc ttg tat cgg aga ggt 2783 Ser Ser Ser Gly Leu Cys Lys Ser Asp Ser Cys Leu Tyr Arg Arg Gly 915 920 925 ggg act gac cac atc acc aac atg tta att cat gaa acg tgg gct agc 2831 Gly Thr Asp His Ile Thr Asn Met Leu Ile His Glu Thr Trp Ala Ser 930 935 940 tcc att gag gct ctc atg cgc aag aac aaa atc att gtg gat gat gca 2879 Ser Ile Glu Ala Leu Met Arg Lys Asn Lys Ile Ile Val Asp Asp Ala 945 950 955 gag gaa gct gac act gag cct gtt tct ggt ggc tct ccc tcg caa gca 2927 Glu Glu Ala Thrp Pro Val Ser Gly Gly Ser Pro Ser Gln Ala 960 965 970 975 gag aag tgt gca aat aga tta gct gcg agc agg atg tgc agt ggg cca 2975 Glu Lys Cys Ala Asn Arg Leu Ala Ala Ser Arg Met Cys Ser Gly Pro 980 9 85 990 act ctg ctt gtt cag gag tct ctc gat tgc cca agg aaa gac tct gtt 3023 Thr Leu Leu Val Gln Glu Ser Leu Asp Cys Pro Arg Lys Asp Ser Val 995 1000 1005 acc gaa tgt aaa cag ccc cca gtg tca tct ttg ag aaa act gct tct 3071 Thr Glu Cys Lys Gln Pro Pro Val Ser Ser Leu Ser Lys Thr Ala Ser 1010 1015 1020 ctt aca aac cac agc cct tta gat tct aaa aaa gaa act tcc tcg tgc 3119 Leu Thr Asn His Ser Pro Leu Asp Ser Lys Lys Glu Thr Ser Ser Cys 1025 1030 1035 cag gac cct gta cca ata aac cac aaa agg cga tca ctt tgc tcg agg 3167 Gln Asp Pro Val Pro Ile Asn His Lys Arg Arg Ser Leu Cys Ser Arg 1040 1045 1050 1055 gaa gtg cct ttg att cag att gaa aca gat cag aga gaa gcc tgt gct 3215 Glu Val Pro Leu Ile Gln Ile Glu Thr Asp Gln Arg Glu Ala Cys Ala 1060 1065 1070 ggg gaa cct gaa ccc ttc ctt tcc aaa agc agc gac gc cta g Gly Glu Pro Glu Pro Phe Leu Ser Lys Ser Ser Leu Leu Glu Glu Ala 1075 1080 1085 gaa ggg cat tcg aat gac aaa aac atc cca gat gtg gtg aga ggt gga 3311 Glu Gly His Ser Asn Asp Lys Asn Ile Pro Asp Val Val Arg Gly Gly 1090 1095 1100 gac aca gcc gtg agc gct tgt caa atc cat agt gac agc ctt gat acc 3359 Asp Thr Ala Val Ser Ala Cys Gln Ile His Ser Asp Ser Leu Asp Thr 1105 1110 1115 aga gat gta cca gag gct gaa gcc tcc aca gaa gcc aga gcc ccc gat 3407 Arg Asp Val Pro Glu Ala Glu Ala Ser Thr Glu Ala Arg Ala Pro Asp 1120 1125 1130 1135 gag gcc ccc aac cct cca agc agc agc gag gag agc acagg 3455 Glu Ala Pro Asn Pro Pro Ser Ser Ser Glu Glu Ser Thr Gly Ser Trp 1140 1145 1150 acc cag ctt gcc aat gag gaa gac aac cca gat gac aca agt agc ttt 3503 Thr Gln Leu Ala Asn Glu Glu Asp Asn Pro Asp Asp Thr Ser Ser Phe 1155 1160 1165 ctc cag ctc agt gag cga tcc atg agt gaa tta gta gaa gaa aag aag 3551 Leu Gln Leu Ser Glu Arg Ser Met Ser Glu Leu Val Glu Glu Lys Lys 1170 1175 1180 att ctt aaa gga ag tcaa aca gag gca cct gca tct gga ccg 3599 Ile Leu Lys Gly Gln Ser Glu Ser Thr Glu Ala Pro Ala Ser Gly Pro 1185 1190 1195 cct acg gga aca gcc agc ccc cag agg agc ctg ctg gtg atc aa c ttt 3647 Pro Thr Gly Thr Ala Ser Pro Gln Arg Ser Leu Leu Val Ile Asn Phe 1200 1205 1210 1215 gac ctg gag cca gag tgt cca gat gcc gag ctc cga gcc act ctg cag 3695 Asp Leu Glu Pro Glu Cys Pro Asp Ala Glu Leu Arg Ala Thr Leu Gln 1220 1225 1230 tgg ata gct gcc tct gaa ctg ggg att ccc acc atc tac ttt aag aaa 3743 Trp Ile Ala Ala Ser Glu Leu Gly Ile Pro Thrh Ile Tyr Phe Lys Lys 1235 1240 1245 tct cag gaa aac aga att gaa aag ttt cta gat gtc gtg cag ctg gtt 3791 Ser Gln Glu Asn Arg Ile Glu Lys Phe Leu Asp Val Val Gln Leu Val 1250 1255 1260 cat cgg aag tcc tgg aaa gtg ggt gat atc ttc cat gca gtt gtc cag 3839 Lys Ser Trp Lys Val Gly Asp Ile Phe His Ala Val Val Gln 1265 1270 1275 tac tgc aaa atg cat gag gag cag aag gat ggg aga ctg agt ctc ttt 3887 Tyr Cys Lys Met His Glu Glu Gln Lys Asp Gly Arg Leu Ser Leu Phe 1280 1285 1290 1295 gac tgg ctc ttg gaa ctg gga taataaggca gtctgccgta tagatcattc 3938 Asp Trp Leu Leu Glu Leu Gly 1300 cttcccttta ttccaactta gattacagtg gtttgttcta aatgctctaa acattc tcaa 3998 aacatcacat cacattagca gaactataaa aaaaaatctg ctactcagat ccactgcata 4058 cagaataagt cagaggaaaa gcaaaatata ggtctgtcca aattcataca acttgtgggt 4118 gagttccaaa gagcttggat tagaagggct ggacaaagag agaattcaat ggggcccaaa 4178 ttagaatgct tataatgaga cccaatctcc aggaaaacaa cactcacata agtttaatca 4238 tataaaatga tttgtaatgt ctctaattag atgaatcaac tagaaacaaa ctcagtggtc 4298 aaaataattt ttaagagtat tccgtaacct atattttact tttctgatta tattaagggg 4358 ctgccagccc ggagaaatac ttaagatatg ggtgagaaat ccccagactt ttatacaaaa 4418 gatttccact ttcaaatcaa tgtcagtaga cattgataaa agtatagcag catcctctac 4478 tgaggtgatt tcatttattc cctgcagccc actgataaat atctcacttc tcccaaatag 4538 tatgtggact cccagctaag cagaaaacta ttgtcattca actgaagaag aggaagataa 4598 aagattgtct tgtttccatc actgtattac ttgtgtaaca tgattacata attcttatcc 4658 taagagaaag ctttcatatt taaaaaaaag tcttttcaga taaaatctgc ttgtgtcttg 4718 aataatatga aatacaaact ttcactttat tttattgtaa attataaaga gattattgtc 4778 ttaaataata tattgagtta gcttcaagct tcctaaaata tgaagagatt gttgtctaaa 4838 gtcacatatt gacattgagc tcagtggcct gtttcatcac gtatgtgctg ctacctgtac 4898 agcagacatg ccgctccagt gacatttata atgacagaag cagggtaatg gtcttgtgtt 4958 tgacatgatc agttaggatc atagactttc cctgactcgt agatattagc cttgaattgg 5018 gggaaaagaa gactttgaca cattttagtt attttaataa cagagattta ctcttttgaa 5078 aaataaaggt atctaatgtc tccctaataa gtcttctttc cttccaacta aatgacctac 5138 acggactttt attttcttga tcaaagaggt gtttattaag gacttctgga taactatact 5198 tttactctat ttttaaagat cacaaagtaa ttttaaatgt gaacaggttc ccataccatg 5258 aatgctggcc tcaccttctc tatcatccac attttgaaat gcaaagaaag ctcccttgta 5318 agccatactt ccttccccac tcccatccta ggatacttgc ccagtgctca ttaggcattt 5378 cttattcaga tagtccaaat ttaggttatt atgcttaatt tgacacatta actaaatgcc 5438 cagttttaaa atatatccat caattcacgc tgaaatgtgc ttctttgtgc tatcaaatgg 5498 aatagaatac acttattttt taaacaatcc cagaatactg tgtgtagact tttgttgtgc 5558 tcaaataaat gtttacttat cttacaaagc tcaaatactg gattgtaacc atgtgatgaa 5618 gttatctatg ttgtacctaa cattgcaaat taatcaataa atctctgttg tc 5670 <210> 73 <211> 5813 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (232) .. (2778) <400> 73 gcggcggcct gaactcacct aacaccgcag cagcaaccgg gcccggccag gttcggcgtt 60 ccgtgagtga acgatttaga aatctggact ggccagtgac ctctgggctt gccattccag 120 cctggtataa cctctggctc catgggcagc tactggctcc tacagaccgg atgaagcaga 180 ctggagacac aagtggagaa aacctccagc tggcaaatcc tcagagtgta g gcc tct 237 Ala Ser 1 ggc tgc cag tcc tgc cca gcc tgc ctc atg gag agg atg aat tgg ctg 285 Gly Cys Gln Ser Cys Pro Ala Cys Leu Met Glu Arg Met Asn Trp Leu 5 10 15 agc aga ctg gcc tcc cgg ggc cct ggg cac cgt ata cct caa ggg gcc 333 Ser Arg Leu Ala Ser Arg Gly Pro Gly His Arg Ile Pro Gln Gly Ala 20 25 30 aat ctc caa acc cca gtc atg gct gat ccc gag acc tgc ctc atg gtc 381 Asn Leu Gln Thr Pro Val Met Ala Asp Pro Glu Thr Cys Leu Met Val 35 40 45 50 ttc aag aat cac tgg tcc cag gtg gtg cga atc ctg gag cgg caa ggc 429 Phe Lys Asn His Trp Ser Gln Val Val Arg Ile Leu Glu Arg Gln Gly 55 60 65 cct cgg gca gct cct ggg ggt gca gac gat ctc agt gct gtg cgc aac 4 Arg Ala Ala Pro Gly Gly Ala Asp Asp Leu Ser Ala Val Arg Asn 70 7 5 80 cac act tac cag atg ttg aca ctg ctg gca gag gac cgt gca gtt ccc 525 His Thr Tyr Gln Met Leu Thr Leu Leu Ala Glu Asp Arg Ala Val Pro 85 90 95 tcg gcc ccc aca ggc cct ggg ccc ctg ctg gag ttt gct ctg cac gag 573 Ser Ala Pro Thr Gly Pro Gly Pro Leu Leu Glu Phe Ala Leu His Glu 100 105 110 gat ctg ctg acc cgt gtg ttg aca tgg cag ctg caa tgg gat gag ctt 621 Asp Leu Leu Thr Arg Val Leu Thr Trp Gln Leu Gln Trp Asp Glu Leu 115 120 125 130 ggg gat ggg gtc gag gaa cgg cgg gct gag caa ctg aaa cta ttt gaa 669 Gly Asp Gly Val Glu Glu Arg Arg Ala Glu Gln Leu Lys Leu Phe Glu 135 140 145 atg cta gt agc gaa gct cgc cag cca ctg ttg cgg cat ggt cca gtt 717 Met Leu Val Ser Glu Ala Arg Gln Pro Leu Leu Arg His Gly Pro Val 150 155 160 cgt gag gct ctg ctc acc ctg ctg gat gcc tgt ggc cgc cct gtg Arg Glu Ala Leu Leu Thr Leu Leu Asp Ala Cys Gly Arg Pro Val Pro 165 170 175 agt agc cca gca ctg gat gaa ggc ttg gtg cta ctt ctc agc cag ctg 813 Ser Ser Pro Ala Leu Asp Glu Gly Leu Val Leu Leu Leu Leu Gln L eu 180 185 190 tgt gtt tgt gtg gcc cag gag cct tca ttg ctc gag ttc ttc ctg cag 861 Cys Val Cys Val Ala Gln Glu Pro Ser Leu Leu Glu Phe Phe Leu Gln 195 200 205 210 cca cct cct gag cct gga gcc gct ccc cgt ctt ctt ctc ttt tct cgc 909 Pro Pro Pro Glu Pro Gly Ala Ala Pro Arg Leu Leu Leu Phe Ser Arg 215 220 225 ctt gtc cct ttt gtg cat cga gag ggc acc ctg ggc cag cag gcc cgt 957 Leu Val Pro Phe Val His Arg Glu Gly Thr Leu Gly Gln Gln Ala Arg 230 235 240 gat gcc cta ctt ctt ctc atg gct ttg tca gct ggg agc ccc act gtg 1005 Asp Ala Leu Leu Leu Leu Met Ala Leu Ser Ala Gly Ser Pro Thr Val 245 250 255 ggc cgc tac atc gcg gat cac tct tac ttc tgc ccg gtg ctg gcc aca 1053 Gly Arg Tyr Ile Ala Asp His Ser Tyr Phe Cys Pro Val Leu Ala Thr 260 265 270 270 ggg ctc agt gcc ctg tac tca tca ctg cct cag ag cca 1101 Gly Leu Ser Ala Leu Tyr Ser Ser Leu Pro Arg Lys Ile Glu Val Pro 275 280 285 290 ggg gat gat tgg cac tgt ctg cga cgg gaa gac tgg ctg gga gtg cca 1149 Gly Asp Asp Trp His Cys Leu Arg Arg Glu Alu sp Trp Leu Gly Val Pro 295 300 305 gcc ctt gca ctc ttc atg agt tcc ctg gag ttc tgc aat gca gta att 1197 Ala Leu Ala Leu Phe Met Ser Ser Leu Glu Phe Cys Asn Ala Val Ile 310 315 320 cag gtg gct caccc ctg gtg cag aag cag ttg gtt gat tat atc cat 1245 Gln Val Ala His Pro Leu Val Gln Lys Gln Leu Val Asp Tyr Ile His 325 330 335 aat ggg ttc ctg gtg cct gtc atg ggt cct gcc ttg cac aag acc tct 1293 Asn Phe Leu Val Pro Val Met Gly Pro Ala Leu His Lys Thr Ser 340 345 350 gtg gag gag atg atc gcc agt acc gcc tat ctg gaa ctt ttc cta cgg 1341 Val Glu Glu Met Ile Ala Ser Thr Ala Tyr Leu Glu Leu Phe Leu Arg 355 360 365 370 agt atc tca gag cct gct ttg ctc cgt acc ttc ctg cga ttc ctg ttg 1389 Ser Ile Ser Glu Pro Ala Leu Leu Arg Thr Phe Leu Arg Phe Leu Leu 375 380 385 ttg cac cgg cat gac acc cc acc atc gac acc ctc gtt gct cgt 1437 Leu His Arg His Asp Thr His Thr Ile Leu Asp Thr Leu Val Ala Arg 390 395 400 att ggc agt aac tcc cgg ctc tgc atg gtc tct ctg agt ctc ttc agg 1485 Ile Gly Ser Asn Ser Ar g Leu Cys Met Val Ser Leu Ser Leu Phe Arg 405 410 415 acc ctc ctg aac ctc agc tgt gag gat gtc ctg ctg cag ctg gtt ctc 1533 Thr Leu Leu Asn Leu Ser Cys Glu Asp Val Leu Leu Gln Leu Val Leu 420 425 agg tat ctt gtt cca tgt aac cac gtt atg ctg agc cag aag ccg gct 1581 Arg Tyr Leu Val Pro Cys Asn His Val Met Leu Ser Gln Lys Pro Ala 435 440 445 450 gtt cgt gat gtg gac cta tat gga cga gca gct gag ag ttt ctc tcc 1629 Val Arg Asp Val Asp Leu Tyr Gly Arg Ala Ala Asp Lys Phe Leu Ser 455 460 465 cta atc cca cgc tgt tgt cgg cac cac gcc ccc agc cca cct cgt cca 1677 Leu Ile Pro Arg Cys Cys Arg His Ala Pro Ser Pro Pro Arg Pro 470 475 480 gag cat gcc tca tgg gca cga ggt cct gga agc cca agt gtg gac tcc 1725 Glu His Ala Ser Trp Ala Arg Gly Pro Gly Ser Pro Ser Val Asp Ser 485 490 495 495 tct tct gtg atg aca gta ccc cgg ccc tcc aca cca tct cgt ctg gct 1773 Ser Ser Val Met Thr Val Pro Arg Pro Ser Thr Pro Ser Arg Leu Ala 500 505 510 ctc ttc ctg cgg cag cag agc ctg ggt ggc tct gag tct cca ggc cca 1821 Le u Phe Leu Arg Gln Gln Ser Leu Gly Gly Ser Glu Ser Pro Gly Pro 515 520 525 530 gcc cct tgc tca cca ggg ctt tct gca tcc ccc gcc tcc agc cct ggc 1869 Ala Pro Cys Ser Pro Gly Leu Ser Ala Ser Pro Ala Ser Ser Pro Gly 535 540 545 cga cgg cct acc cct gca gag gag cct gga gag ctg gaa gac aat tac 1917 Arg Arg Pro Thr Pro Ala Glu Glu Pro Gly Glu Leu Glu Asp Asn Tyr 550 555 560 ctg gag tat ctg cgt gag gcagt cgt ggt gtg gac cgc tgt gtc cga 1965 Leu Glu Tyr Leu Arg Glu Ala Arg Arg Gly Val Asp Arg Cys Val Arg 565 570 575 gcc tgc cgt acc tgg tct gcc ccc tat gat ggc gag cgg ccc tct cct 2013 Tla Cys Arg Ser Ala Pro Tyr Asp Gly Glu Arg Pro Ser Pro 580 585 590 gag ccc agt cct ttt ggc tcc cgg act aag aaa cgc agc cta ctg cct 2061 Glu Pro Ser Pro Phe Gly Ser Arg Thr Lys Lys Arg Ser Leu Leu Pro 595 600 605 610 gag gag gac agg aac aac gtg ggg gaa ggg gag gag gaa gag ctg ggg 2109 Glu Glu Asp Arg Asn Asn Val Gly Glu Gly Glu Glu Glu Glu Leu Gly 615 620 625 agg agg ggg cgg gct ggg ggt gca ggg gag ggt cac ctg ccc 2157 Arg Arg Gly Arg Ala Gly Gly Ala Gly Glu Gly Pro Gly His Leu Pro 630 635 640 cct ccc cag ctc aat gga gtg cca gga tca tgg cct gag ggg gcc aag 2205 Pro Pro Gln Leu Asn Gly Val Pro Gly Ser Trp Pro Glu Gly Ala Lys 645 650 655 aag gtt cgt ctg gtg cca aag gag gga gct ggg gaa ctg cta gag ggc 2253 Lys Val Arg Leu Val Pro Lys Glu Gly Ala Gly Glu Leu Leu Glu Gly 660 665 670 gg tcc gcc atg gca gga cta gag ggc ttt ggg cag gag ctc cgg 2301 Ile Ser Glu Gly Met Ala Gly Leu Glu Gly Phe Gly Gln Glu Leu Arg 675 680 685 690 gag cta gag gtg gca ttg agc aat ggg gga act ccc tcag Glu Leu Glu Val Ala Leu Ser Asn Gly Gly Thr Gly Ser Glu Ser Pro 695 700 705 tta gaa cct cca ctg ccc ctt gag gag gag gag gcc tac gag agc ttc 2397 Leu Glu Pro Pro Leu Pro Leu Glu Glu Glu Glu Ala Tyr Glu Ser Phe 710 715 715 acc tgt ccc cct gag ccc cct ggc ccc ttc ctc agc agc cct ttg cgg 2445 Thr Cys Pro Pro Glu Pro Pro Gly Pro Phe Leu Ser Ser Pro Leu Arg 725 730 735 act ctc aac cag ctg cca agc cag ccc ttc act ggt aag cta ctt agc 2493 Thr Leu Asn Gln Leu Pro Ser Gln Pro Phe Thr Gly Lys Leu Leu Ser 740 745 750 cta ggc ctt ccc ttc tgt gta ctc ttt gca tgt tct cga cat gtt tgt 2541 Leu Gly Leu Pro Phe Cys Val Leu Phe Ala Cys Ser Arg His Val Cys 755 760 765 770 gct ggt ttc ttg gac ctc ttg gcc atg tca ttt ctg tgt act tgc cta 2589 Ala Gly Phe Leu Asp Leu Leu Ala Met Ser Phe Leu Cys Thr Cys Leu 780 785 gcc cct cat cca tcc tgc ttg cat cac ttc cag ata cgt gtc atg tca 2637 Ala Pro His Pro Ser Cys Leu His His Phe Gln Ile Arg Val Met Ser 790 795 800 tac ttg tgt ccc tgt gtc tgt ctg tac gtc ttc cat gct tgt gct ggt 2685 Tyr Leu Cys Pro Cys Val Cys Leu Tyr Val Phe His Ala Cys Ala Gly 805 810 815 ttg agt att gac tta cat ctg agc ctt gta tgt atg tcc tat gtg cat 2733 Leu Ser Ile Asp Leu His Leu Ser Leu Val Cys Met Ser Tyr Val His 820 825 830 gtt cct cct ctt tcc cta gtc tgg cca ttt cct gcg att tgt aat 2778 Val Pro Pro Leu Ser Leu Val Trp Pro Phe Pro Ala Ile Cys Asn 835 840 845 taggatattc tgtgtt tgat gtttcctggt gaatcacagc aatatttctg aaccatattg 2838 aagacgtatg tgctgtcctg tatggagagg cacctaaaca ctctctatgc cattccgtcc 2898 agtttatctg tctgggtctt gggttttctg tcagctctcc tggggcctaa ggttaacctt 2958 ctggtatttt tctccctact cagctccttc ctccccacct cttcaaagaa ggacttgatt 3018 tcaagttttt cctgttcgct ttccttgtac cttcttggtt gctgtgactg tctgctagca 3078 ctaagactgt cttaagcaga tagagtgcaa tttctttgaa ggcaaatgac aaagcgtggc 3138 cctgagctcc ctgactgagt tcatttggac tctcaaggat gccctggagc tagactcgat 3198 ctgagtggtt ggactaactc ctctttgttt ttgtatgaga gccagcttac cccgccattc 3258 taaacctcag gccaggaaaa ccaaaaaaca aaaaaaccaa ccaaacaaaa aacaaaccca 3318 cctctgagaa gtagtagcta aggctaagat cacaggcctt ggattaggca taccttacat 3378 tagcctccca tctctgccat agatgcatat aaatcattta ctacaattat ggcacattgt 3438 gagaactcag caagtggtag cttttcacta ggatctctgg gtacatagca gatttaagtt 3498 gactaaggca aacactcatc ttccagttgt tcatagtcag attgtcatgc cttgataagt 3558 tcatgtcctg actgggcctg ggagatgctg gccatcctgc tcatacagca ccagggcttc 3618 tgccatggag ttgtgccaat tccctcttct tgcctcctac agaaaatcta tctttccatt 3678 tatttagcct ctgctctgtt cctttcagct cagtaccact aggtgatagc gtgcaggttt 3738 taccacagtc ttgaagtatt aattgaagct tttgtctttt tttcctttgg taaacttatc 3798 tgagcttttc aatttttttt ttccaagaaa cttccaggaa atgaaaggaa caggacaaaa 3858 ttatggggcg tcttaggact ctgttaagct agagttgttt tgaagctaat gctagacatg 3918 tgcacctgga gtgaaaaatg ttttagcatc tttttcagga ttcactccct cctgccctcc 3978 atcattctcc tgtctcaatg catagtacag ttcttagata tatactccct ttccccaaaa 4038 aaatccctaa tcagaaggac tgtgatggtt atagaggcct actgctggtg atctggctta 4098 gctgaggtca gttttcccag tggataatgc tgatcctttc ccttccttct ctcccaccaa 4158 agagtctgtc ctcagtcagt ttctctgccc ctgcactaag ctatcctttt actacatatt 4218 ctgttccacc gtcttggttc ccagcttctg aaagacaaaa ctgatgtctt ctctggtcct 4278 ccaaatattt ttttccctaa ctttaaattg gctcacatag ttactttgtc tttgcaacac 4338 catcttctag ctttctttct gagcaggttt agtgttatcc tccgtttttt gtggaaccta 4398 attctttttg gacctaatta ctttctcaac ctatttgttc ttctgttgtg cctcttgggt 4458 gaatctttta taaaaacaat atgtaa ttgt agcttatggt tataactgaa cacttaaaat 4518 ttgccagatc tgaggctaaa tgctttatat tgataactct ttgatcctct tcatcacctt 4578 atgaggtagg tatattttcc tattttacga actaggaaac taaggcttgg acaattttga 4638 cctgtccaaa ctagtaaagg gcaaagccag tgaaaccaga tctttcagag tccagagcct 4698 aagatctggc ttgtcagctt gaatgtgtgt aaagctggca tctggaatct tgtgggtcca 4758 tatggtgtct gccatcttat ttcctccaga ataggtggcc acgggatatt taaacatacc 4818 cagaggctga catacaaata cctttcatct ggtgggggtc tcttgttttg gggaggaatg 4878 cgtgcgatgt gcattgtgtt caggctttgt atccttgtgc ccacctcccc cccaacccag 4938 gccccttcat ggctgtgctc tttgccaaac tcgagaacat gctgcagaac tccgtctatg 4998 tcaacttcct gctgacgggg ctggtggccc agctggcctg tcacccccag cccctgctcc 5058 gctctttcct gctcaacacc aacatggtct tccagcccag tgtcaagtcc ctgctgcagg 5118 tgctgggctc tgtgaagaat aagattgaga actttgcggc ttcccaggag gacttcccag 5178 cactgctgtc caaagccaag aagtacctca ttgcccgtgg caagttggac tgggctgagg 5238 gccctgcagc aggacctgcc ccacgccgtt ctgatcccct agtgaagagc cggaggccat 5298 ccttggggga gttactcctg cggcatgcac acagtccaac cagggcccgg caggcggcac 5358 aattggtcct tcagcctggg cgagacggag caggacttgg cctaagtggg ggctcccctg 5418 gggcttcaac tccagttcta ctcacccggg gcggggcccc tgaacgccaa ggtgaggctc 5478 ttcgagtcaa gaatgctgtc tactgtgcag tcattttccc tgaatttctc aaggagttgg 5538 ctgccatctc ccaggctcat gccgtcacct cgcctttctt gttggagact tcagaggaag 5598 gatctggccc tctcatctca ggctgtgggc ccctcaatcc ttaactttct tccatggaca 5658 atcagggcca tgggtggccc gggctggggc tagggcacag gctccttttt atgtttggag 5718 gcagtggcaa aaggactttt taatttattt cagatgaatg ttttatggag aacttgttgc 5778 aatatgtata aaagggaaat ctctattctg tgctc 5813 <210> 74 <211> 5555 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (28) .. (1617) <400> 74 atttctccac tgtagtctct aggatga gta atg gaa ggg aaa cat tcc cag atc 54 Val Met Glu Gly Lys His Ser Gln Ile 1 5 ctc aaa cta tcg aag ctc act cca ggc ctg tat gaa ttc aaa gtg Leu Lyu Lyu Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile 10 15 20 25 gta gag ggt caa aat gcc cat ggg gaa ggc tat gtg aac gtg aca gtc 150 Val Glu Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val 30 35 40 aag cca gag ccc cgt aag aat cgg ccc ccc att gct att gtg tca cct 198 Lys Pro Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro 45 50 55 cag ttc cag gag atc tct ttg cca acc act tct aca gtc att gat ggc 246 Gln Phe Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly 60 65 70 agt caa agc act gat gat gat aaa atc gtt cag tac cat tgg gaa gaa 294 Ser Gln Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu 75 80 85 ctt aag ggg cct cta aga gaa gag aag att tct gaa gat aca gcc ata 342 Leu Lys Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile 90 95 100 105 tta aaa cta agt aaa ctc gtc cct ggg aac tac act ttc agc ttg act 390 Leu Lys Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr 110 115 120 gta gta gac tct gat gga gct acc aac tct act act gca aac ctg aca 438 Val Val Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr 125 130 135 gtg aac aaa gct gtg gat tac ccc cct gtg gcc aac gca ggc ccc aac 486 Val Asn Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn 140 145 150 caa gtg atc acc ctg ccc caa aac tcc atc acc ctc ttt ggg aac cag 534 Gln Val Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln 155 160 165 agc act gat gat cat ggc atc acc agc tat gag tgg tca ctc agc cca 582 Ser Thr Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro 170 175 180 185 agc agc aaa ggg aaa gtg gtg gag atg cag ggt gtt aga aca cca acc 630 Ser Ser Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr 190 195 200 tta cag ctc tct gcg atg caa gaa gga gac tac act tac cag ctc aca 678 Leu Gln Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr 205 210 215 gtg act gac aca ata gga cag cag gcc act gct caa gtg act gtt att 726 Val Thr Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile 220 225 230 gtg caa cct gaa aac aat aag cct cct cag gca gat gca ggc cca gat 774 Val Gln Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp 235 240 245 aaa gag ctg acc ctt cct gtg gat agc aca acc ctg gat ggc agc aag 822 Lys Glu Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys 250 255 260 265 agc tca gat gat cag aaa att atc tca tat ctc tgg gaa aaa aca cag 870 Ser Ser Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln 270 275 280 280 gga cct gat ggg gtg cag ctc gat gct aac agc agt gtt gct act 918 Gly Pro Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr 285 290 295 gtg act ggg ctg caa gtg ggg acc tat gtg ttc acc ttg act gtc aaa 966 Val Thr Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys 300 305 310 gat gag agg aac ctg caa agc cag agc tct gtg aat gtc att gtc aaa 1014 Asp Glu Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys 315 320 325 ga a gaa ata aac aaa cca cct ata gcc aag ata act ggg aat gtg gtg 1062 Glu Glu Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val 330 335 340 345 att acc cta ccc acg agc aca gca gag ctg gat ggc tct aag tcc tca 1110 Ile Thr Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser 350 355 360 gat gac aag gga ata gtc agc tac ctc tgg act cga gat gag ggg agc 1158 Asp Asp Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser 365 370 375 cca gca gca ggg gag gtg tta aat cac tct gac cat cac cct atc ctt 1206 Pro Ala Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu 380 385 390 ttt ctt tca aac ctg gtt gag gga acc tac act ttt cac ctg aaa gtg 1254 Phe Leu Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val 395 400 405 acc gat gca aag ggt gag agt gac aca gac cgg acc act gtg gag gtg 1302 Thr Asp Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val 410 415 420 425 aaa cct gat ccc agg aaa aac aac ctg gtg gag atc atc ttg gat atc 1350 Lys Pro Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile 430 435 440 aac gtc agt cag cta act gag agg ctg aag ggg atg ttc atc cgc cag 1398 Asn Val Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln 445 450 455 att ggg gtc ctc gg ggt tcc gac atc att gtg caa aag 1446 Ile Gly Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys 460 465 470 att cag ccg tac acg gag cag agc acc aaa atg gta ttt ttt gtt caa 1494 Ile Gln Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln 475 480 485 aac gag cct ccc cac cag atc ttc aaa ggc cat gag gtg gca gcg atg 1542 Asn Glu Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met 490 495 500 505 ctc aag agt gag ctg cgg aag caa aag gca gac ttt ttg ata ttc aga 1590 Leu Lys Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg 510 515 520 gcc ttg gaa gtc aac act gtc ag gag agatt gatt Glu Val Asn Thr Val Ser Glu 525 530 caagagccta cctagtgcct gcagctcacc cattggtcct ttctgtcctt ggccttcatc 1697 ttcttttctc tgggaagatg gagataatca ttctcttgca ctactattac catgaaagag 1757 tcctgattca tcactgggga ttcttaactt ggggcccatg ggcccctgag atcgtgttca 1817 gaaggctgtg agcttgagtg gggaaaaatt tacatctttg ttttcactaa cctctgactg 1877 aaactcactg tttacttcaa tgatcaatgt aggcaacaaa ctacagtagt atcaacagaa 1937 cctgtggctt tgaggcaata gaaatcacaa ataatttcct atcacattac atgatgtcat 1997 ttttacttat cactacttca aaattatgat agttgttaaa cccacttcta gctcttgttg 2057 tttaatgctt atttatttat ttatttattt atttatttat tttgagatag agtcttgctc 2117 tgttgcccag gctgcagtgc agtggtgtaa tctcagctca ctgcaacctc cgcccccccg 2177 ggttcaagtg attctcctgc ctcagcctcc caaatagctg ggattacagg catgcaccac 2237 cacgcccagc tgatttttat atttttagta gagatggggt ttcgtcatgt tatccaggct 2297 ggtcttgaac tcctgacttc aagtgatctg cctgcctcgg cctcccaaag tgctgggatt 2357 ataggtgtga gctaccatgc ccagcctgtc ttcttaaata tttcaaaaac gtttaatata 2417 attattgcct tcctttgaag tactataggt attttatttt tccaattgtg agaaggggat 2477 gtgtgggaca taaaagatta agaattgctg atatagacaa acaacaagtg aagacaggct 2537 ggaagtgtct ttctagtggc ctcctgactg ctccagtttt gtccagtcga gatgagaaag 2597 gcag gcacca tgcccaaggt gggtctcgag gacatttcac cacatagcat taatctgggg 2657 tgctttggtg ccctcatggg ctctaggtgc tgcttgtcac ccctggctga gtcttgttga 2717 ctttcttccc tttgctgcca ctctcagcat gtcagctgaa ctgttccgac catggccact 2777 gtgactcgtt caccaaacgc tgtatctgtg accctttttg gatggagaat ttcatcaagg 2837 tgcagctgag ggatggagac agcaactgtg agtggagcgt gttatatgtt atcattgcta 2897 cctttgtcat tgttgttgcc ttgggaatcc tgtcttggac tgtgatctgt tgttgtaaga 2957 ggcaaaaagg aaaacccaag aggaaaagca agtacaagat cctggatgcc acggatcagg 3017 aaagcctgga gctgaagcca acctcccgag caggtagggg ccctgggtgc cagagcttct 3077 aggtctgtgc actctctctg tggaaggctg ctgtcactag cccctcctga gtgtgtcact 3137 aacagcccac tgtgcttgca aagcattttg ttcccttttg cctgatgaag actgagggtc 3197 agatttgccc tgagctgcac tggacaaaat gcctccagga cccacttcgc gtgctacttc 3257 cgcttggcgg gggtgctggg cctgttgttt tcctttgcct gggcattctc ctcatgtttc 3317 ccacctggag ttccgctttt ccaactgccc caggtagtca gggtcaggga ccttggactt 3377 gtctcttact gctgaccagt ctgtgcttta tgggcagaga tgagacccag gcccgtgtct 3437 gccagctgac cacctttcag ccagccttgt tctcctgtct tcctatcttt atcatttggc 3497 aagtcctcag cttctgtcag tgtcttaggg cagataggag ggcatttcct tgcacaaaca 3557 gtaagatgac tttgagtgat ggcactggga gatcagggca ggtagtaggc cttccttcct 3617 ccgctgggct gggtcacctg gcgagggttt cactcatcat ggatgccatg ggacaggtat 3677 cattggttta tgagagctag actctataaa gcgattccta aacactctgc aagtagaact 3737 atttttatat aaagcattta ttaaacactt ttcatgctta aagctttgtg ttagggagag 3797 gctatggggg tatagggagt catcagacac aggctgtgct ctcagtctag tgagggagaa 3857 aagacacaca gtagcagaag agaacaggct cacagcagtc tggactctgc accaagcagc 3917 tcgatccacc aacactgtca aggtggagac tggaggtggt ggggcttgaa atgagcccag 3977 gaaaccagag cagtgagggc gggcggggca tttcacccag gaatattgag aatgagggcc 4037 tggaggtgaa atgtgcaaaa cccacccctc acactgcagc caaggttttt atcatgttac 4097 tctgatcatg tttttcaccc cctgacattc ttcaatgact tactatttct agcacaaaaa 4157 gctagaactt ttggtctggt agatgtggcc tttgtgagct tacatcagtt tgcttttctg 4217 gaatctttct ctttgctgat ctccctcttt tctaaacaag ttcttctggt tcatccagta 4277 atctctttct tttt taaaaa tgtggcgaca aggtcttgct ctgtcaccca ggctggagtg 4337 cagtggtata gtcatagctc actgcaacct ccagctcctg agctcaagtg gtcctcctgc 4397 ttcagcctcc caaagcagct gggactacag gcatgcacca ccatacccag ccctagaaag 4457 ctctttctta tccctccctt aacctcctca agttgtgctc acctttctct cacatgcctg 4517 ggtcggcatt tctctcgctg tctcatgatt agttatgttt gcctgtctcc ccacccatca 4577 gtgaaatccc tgagggcagg ggctgtctca ttcatctgtg gatatggagc gggaccacta 4637 tgtgccaggc cctgtgccag acactgctta tattgtggtg aatcaaacgg acagacttca 4697 ctcttgtgta gcttatgtca gacagacatt aagcaaactc acaaatacat aaaatatgct 4757 cataaaaggc ctttatgaag aaaaacactt aagctgagac ctggataagt gggagctagc 4817 cagataaagc tgcaggaaat agcattccag gcaaaggaac aaaactggtg cagacccagc 4877 tgctagaagg agcagagagc atttgaggag gtagaagaag gtgacatgat ggacaggttc 4937 accttcccac agagtaaggg gtgagtgacc caaggctcaa tggatgagca gggtccctgc 4997 tgaggacttc tcttgagtac aatggggagc cactgatagc tttttaaggg gatgaatggt 5057 gggatttggt ttacatttat tattatttga gacagagtct cactcttatc acccaggcag 5117 gagtgcagtg gtgcgatcaa ggcccactgc agtcttgacc tcctgggctc aggtgatcct 5177 tccacctcag cttcctaagt agctgggacc acaggcatgc gccaccatcc ccaggttttt 5237 ttgttgttgt tgttgttgtt ttgtattttt ggtagagacg gggtttcatc atgttgccta 5297 ggctgttctt gaactcctgg gcttaagtga tctgcctgcc ttggtctcct aaagtgctgg 5357 gattataggt gtgagccatg gcacccggtc ttggtttata ttttaaaaag acaactgtgt 5417 agctgggcgt ggtggtgggt gcctgtaatc ccagctactc gagaggccaa ggcaggagaa 5477 ttgctagaac ctgggggtgt gaaggtttca gtgaactgag atcactccaa cctgggcaat 5537 aaagccagac tctgtctc 5555 <210> 75 <211> 5337 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2283) <400> 75 cgg acc att gtg cca aat gca ccg gcc act atc ccc ctg ctg gcc gta 48 Arg Thr Ile Val Pro Asn Ala Pro Ala Thr Ile Pro Leu Leu Ala Val 1 5 10 15 gcc cca ccg ggc gtg gct gcc ctg tcc att cat tct gcc gtg gcc cag 96 Ala Pro Pro Gly Val Ala Ala Leu Ser Ile His Ser Ala Val Ala Gln 20 25 30 ctc cca ggc caa cct gtg tac cca gcg gcc ttc cca cag atg gcg cct 144 Leu Pro Gly Gln Pro Val Tyr Pro Ala Ala Phe Pro Gln Met Ala Pro 35 40 45 act gac gtc cct cct tcc ccc cat cac acg gtg cag aat atg agg gcc 192 Thr Asp Val Pro Pro Ser Pro His His Thr Val Gln Asn Met Arg Ala 50 55 60 acc cct cca cag ccg gca ctg cct cca caa ccc aca ctg ccc cca caa 240 Thr Pro Pro Gln Pro Ala Leu Pro Pro Gln Pro Thr Leu Pro Pro Gln 65 70 75 80 ccc gtg ctg ccc ccg caa ccc acg ctg ccc cct caa cct gtg ttg ccc 288 Pro Val Leu Pro Pro Gln Pro Thr Leu Pro Pro Gln Pro Val Leu Pro 85 90 95 ccg caa ccc aca cgg ccc cct caa cct gtg ctg ccc ccg caa ccc atg 336 Pro Gln Pro Thr Arg Pro Pro Gln Pro Val Leu Pro Pro Gln Pro Met 100 105 110 ctg ccc cca caa cct gtg ctg ccc ccg cag ccg gca ctg cct gtg cgc 384 Leu Pro Pro Gln Pro Val Leu Pro Pro Gln Pro Ala Leu Pro Val Arg 115 120 125 cct gag ccc ctc cag ccc cac ctt cct gaa caa gct gca gct gct 432 Pro Glu Pro Leu Gln Pro His Leu Pro Glu Gln Ala Ala Pro Ala Ala 130 135 140 aca cca ggg agc cag att ctg ctt ggc cac cca gct ccc tat gct gtg 480 Thr Pro Gly Ser Gln Ile Leu Leu Gly His Pro Ala Pro Tyr Ala Val 145 150 155 160 gac gtc gcc gct cag gtc ccc acc gtg cct gtg cca ccg gct gcg gtc 528 Asp Val Ala Ala Ala Gln Val Pro Thr Val Pro Val Pro Pro Ala Ala Val 165 170 175 ctc tcc ccg cct ctg ccg gaa gtg ctg ctg cct gcc gcc cct gag ctc 576 Leu Ser Pro Pro Leu Pro Glu Val Leu Leu Pro Ala Ala Pro Glu Leu 180 185 190 ctg cct cag ttc ccc agc tcc ctg gcc acg gtg tct gcc tct gtg cag Gln Phe Pro Ser Ser Leu Ala Thr Val Val Ser Ala Ser Val Gln 195 200 205 agt gtg ccc acc cag act gcc aca ctt ctg cca cca gca aac cca ccg 672 Ser Val Pro Thr Gln Thr Ala Thr Leu Leu Pro Pro Ala Asn Pro P ro 210 215 220 ctg cct ggc ggg ccc ggg atc gcc agc cct tgc cca act gtc cag ctg 720 Leu Pro Gly Gly Pro Gly Ile Ala Ser Pro Cys Pro Thr Val Gln Leu 225 230 235 240 acg gtg gaa cca gtc caa gag gag cag gcc tca cag gac aag ccg ccc 768 Thr Val Glu Pro Val Gln Glu Glu Gln Ala Ser Gln Asp Lys Pro Pro 245 250 255 ggc ctc ccg cag agc tgt gag agc tat gga ggt tct gat gtc act tct 816 Gly Leu Pro Gln Ser Cys Glu Ser Tyr Gly Gly Ser Asp Val Thr Ser 260 265 270 gg aaa gag ctg agt gac agc tgt gaa ggc gcc ttt gga ggg ggc agg 864 Gly Lys Glu Leu Ser Asp Ser Cys Glu Gly Ala Phe Gly Gly Gly Arg 275 280 285 g gag ggc agg gca gcc cga aaa cac cac cgc agg tcc acg cgt gcg 912 Leu Glu Gly Arg Ala Ala Arg Lys His His Arg Arg Ser Thr Arg Ala 290 295 300 cgc tcc cgg cag gag agg gcc agc cgg ccc cgg ctt accc aac 960 Arg Ser Arg Gln Glu Arg Ala Ser Arg Pro Arg Leu Thr Ile Leu Asn 305 310 315 320 gtg tgc aac act ggg gac aag atg gtg gag tgc cag ctg gag aca cac 1008 Val Cys Asn Thr Gly Asp Lys Met Val Glu CysGln Leu Glu Thr His 325 330 335 aac cac aag atg gtg acc ttc aag ttc gac ttg gac ggg gac gca ccc 1056 Asn His Lys Met Val Thr Phe Lys Phe Asp Leu Asp Gly Asp Ala Pro 340 345 350 gat gaa att gcc acg tat atg gtg gag cat gac ttt atc ctg cag gcc 1104 Asp Glu Ile Ala Thr Tyr Met Val Glu His Asp Phe Ile Leu Gln Ala 355 360 365 gag cgg gaa acg ttc atc gag cag atg aag gat gtc atg gac aag gcalu Glulug Thr Phe Ile Glu Gln Met Lys Asp Val Met Asp Lys Ala 370 375 380 gag gac atg ctc agc gag gac aca gac gcc gac cgt ggc tcc gac cca 1200 Glu Asp Met Leu Ser Glu Asp Thr Asp Ala Asp Arg Gly Ser Asp Pro 385 390 395 400 ggg acc agc ccg cca cac ctc agc acc tgc ggc ctg ggc acc ggg gag 1248 Gly Thr Ser Pro Pro His Leu Ser Thr Cys Gly Leu Gly Thr Gly Glu 405 410 415 gag agc cga caa tcc caa gcc aac gcc ccc gtg tat cag cag aac gtc 1296 Glu Ser Arg Gln Ser Gln Ala Asn Ala Pro Val Tyr Gln Gln Asn Val 420 425 430 ctg cac acc ggg aag agg tgg ttc atc atc tgt ccg gtg gct gag cac 1344 Leu His Thr Gly Lys Arg T rp Phe Ile Ile Cys Pro Val Ala Glu His 435 440 445 ccc gcc ccc gag gcc cct gaa tct tcg ccc cca ctt cct cta agc tcc 1392 Pro Ala Pro Glu Ala Pro Glu Ser Ser Pro Pro Leu Pro Leu Ser Ser 450 455 460 ctg ccg cca gaa gcc agc caa gat tca gcg ccc tat aaa gac cag ctg 1440 Leu Pro Pro Glu Ala Ser Gln Asp Ser Ala Pro Tyr Lys Asp Gln Leu 465 470 475 475 480 tcc tcg aag gaa caa ccc agc ttt cta gcc agt ctg agc 1488 Ser Ser Lys Glu Gln Pro Ser Phe Leu Ala Ser Gln Gln Leu Leu Ser 485 490 495 cag gcg ggc ccc agc aac cct cct ggg gca ccc cca gcc cct ttg gcc 1536 Gln Ala Gly Pro Ser Asn Pro Pro Gly Ala Pro Pro Ala Pro Leu Ala 500 505 510 ccc tcc tcc cct cct gtg act gct ctg ccc caa gat gga gca gct cca 1584 Pro Ser Ser Pro Pro Val Thr Ala Leu Pro Gln Asp Gly Ala Ala Pro 515 520 525 gcc acc agc acc atg cca gag cca gcg tca gga act gcc agc cag gca 1632 Ala Thr Ser Thr Met Pro Glu Pro Ala Ser Gly Thr Ala Ser Gln Ala 530 535 540 ggg ggt cca ggg aca cct cag ggg ctg acc agt gag ctc gag acg tct 1680 Gly G ly Pro Gly Thr Pro Gln Gly Leu Thr Ser Glu Leu Glu Thr Ser 545 550 555 560 cag cca cta gcg gag act cac gag gcc ccg ctt gct gtg cag ccc ctc 1728 Gln Pro Leu Ala Glu Thr His Glu Ala Pro Leu Ala Val Gln Pro Leu 565 570 575 gtg gtg ggc cta gca cct tgc act cca gct cca gag gct gcc tca acc 1776 Val Val Gly Leu Ala Pro Cys Thr Pro Ala Pro Glu Ala Ala Ser Thr 580 585 590 agg gac gcc agt gcc cca agg gag ccc ctg cca cct cct gca cct gag 1824 Arg Asp Ala Ser Ala Pro Arg Glu Pro Leu Pro Pro Pro Ala Pro Glu 595 600 605 ccc agc ccc cac agc ggg acc cca cag ccc gcc ttg ggt cag cct gct 1872 Pro Ser Pro His Ser Gly Thr Pro Gln Pro Ala Leu Gly Gln Pro Ala 610 615 620 ccc ctg ctt cct gcc gca gtg ggg gcc gtc agc ctg gcc acc tcc cag 1920 Pro Leu Leu Pro Ala Ala Val Gly Ala Val Ser Leu Ala Thr Ser Gln 625 630 630 635 640 ctc cca agc cca ccc ctg ggg ccc acc gtc ccc cca cag cca ccc tcg 1968 Leu Pro Ser Pro Pro Leu Gly Pro Thr Val Pro Pro Gln Pro Pro Ser 645 650 655 gcc ctg gag tcg gat ggg gaa ggg ccg ccc ccc agg gt g ggc ttt gtg 2016 Ala Leu Glu Ser Asp Gly Glu Gly Pro Pro Pro Arg Val Gly Phe Val 660 665 670 gac agc acc atc aag agc ctg gac gag aag ctg cgg act ctg ctc tac 2064 Asp Ser Thr Ile Lys Ser Leu Asp Glu Lys Leu Arg Thr Leu Leu Tyr 675 680 685 cag gag cac gtg ccc acc tcc tca gcc tca gct ggg acc cct gtg gag 2112 Gln Glu His Val Pro Thr Ser Ser Ala Ser Ala Gly Thr Pro Val Glu 690 695 700 gtg ggc gac aga gac ttc acc ctg gag ccc ctg aga ggg gac cag ccc 2160 Val Gly Asp Arg Asp Phe Thr Leu Glu Pro Leu Arg Gly Asp Gln Pro 705 710 715 720 cgc tca gag gtc tgc ggg ggg gac ctg gcc ctg ccc ccagtg Arg Ser Glu Val Cys Gly Gly Asp Leu Ala Leu Pro Pro Val Pro Lys 725 730 735 gag gcg gtc tca ggg cgt gtc cag ctg ccc cag cct tgg tgg aga agt 2256 Glu Ala Val Ser Gly Arg Val Gln Leu Pro Gln Pro Trp Trp Arg Ser 740 745 750 cag aac tgg ccc cca ctc gag ggg ccg tgatggagca gggcacgtcc 2303 Gln Asn Trp Pro Pro Leu Glu Gly Pro 755 760 tcgtcaatga cagagtcgtc tcccaggagt atgctaggct atgacagaga tggaaggcag 63 gtggcctcag actcccatgt ggtccccagc gtcccccagg atgtacctgc ttttgtgaga 2423 cctgcacgtg tggagcccac agacagggat ggtggagaag ctggagaaag ctcggcagag 2483 cccccgccga gtgacatggg cacagtgggg gaccaggcta gccaccccca gacactcggc 2543 gctcgagctt tggggtcccc tcggaaacgt ccagagcagc aggatgtcag ctcaccagcc 2603 aagactgtgg gccgtttctc ggtggtcagc actcaggacg agtggaccct ggcctccccc 2663 cacagcctga gatactctgc cccacccgac gtctacctgg acgaggcccc ctccagcccc 2723 gacgtgaagc tggcagtgcg gcgggcgcag acggcctcct ccatcgaggt cggcgtgggc 2783 gagcccgtgt ccagcgactc tggggacgag ggccctcggg cgagaccccc ggtgcagaag 2843 caggcgtccc tgcccgtgag tggcagcgtg gctggcgact tcgtgaagaa ggccaccgcc 2903 ttcctgcaga ggccttctcg ggccggctcg ctgggccccg agacacccag cagggtgggc 2963 atgaaggtcc ccacgatcag cgtgacctcc ttccattccc agtcgtccta catcagcagc 3023 gacaatgatt cggagctcga ggatgctgac ataaagaagg agctgcagag tctgcgggag 3083 aagcacctga aggagatctc ggagctgcag agccagcaga agcaggagat cgaagctctg 3143 taccgccgcc tgggcaagcc actgcccccc aacgtgggct tcttccacac ggcacccccc 3203 act ggccgcc ggagaaaaac cagcaagagc aagctgaagg caggcaagct gctaaatccc 3263 ctggtgcggc agctcaaggt cgtggcctcc agcacaggtc acttggctga ctccagcaga 3323 ggccctcccg ctaaggaccc tgcccaagcc agtgtggggc tcactgcaga cagcacgggc 3383 ctgagcggga aggcagtgca gacccagcag ccctgctccg tccgggcctc cctgtcttcg 3443 gacatctgct ccggcttagc cagtgatgga ggcggagcgc gtggccaagg ctggacggtt 3503 taccacccaa cgtctgagag agtgacctat aagtctagta gcaaacctcg tgctcgattc 3563 ctcagtggac ccgtatctgt gtccatctgg tctgccctga agcgtctctg cctaggcaaa 3623 gaacacagca gtaggtcctc caccagcagc ctggccccag gccctgagcc aggcccccag 3683 cccgccctgc acgtccaggc gcaggtgaac aacagcaaca acaagaaggg taccttcacg 3743 gacgacctgc acaagctggt ggacgagtgg acgagcaaga cggtgggggc cgcgcagctg 3803 aagcccacgc tcaaccagct gaagcagacc cagaagctgc aagacatgga ggcccaggca 3863 ggctgggctg cccctggcga ggcgcgggct atgaccgcac ctcgagcagg agtggggatg 3923 ccacgtctgc ccccagcgcc cggccctctg tccaccacgg tcattcccgg agccgccccg 3983 accctgtccg tgcccacacc agatggcgcc ctcggaaccg cccggagaaa ccaggtgtgg 4043 tttggcct cc gagtcccccc caccgcctgc tgtgggcaca gcactcagcc gcgaggggga 4103 cagcgggtgg gcagcaagac tgcttccttt gcggcttcag accctgttcg ctcctaggtt 4163 cctgtggtcc acgcgccgtc tccacaccca cttcctatac ttgagttgat ggttagaacc 4223 ttgtcgtcac cctgcagaag tacagtgcct tgaatgccag cttttccgtt ccctgatgaa 4283 aagatatgtt aaaaaaaatt atcggaaaag gtttcatttg caattggctt gtgcattgat 4343 aatctttatt tactgtttta agttgcagag atgtgaatgg tttacaaatc tgaagctgaa 4403 gttcaatctt tggttttctg ttgtaaatgc cttttacaaa cattgaatta gctaccttaa 4463 gtattgaaga gcttccattg ctaggtgagc cctgctttgt cctcagtaga gtgccggttc 4523 cctgggctca tccaggggct gagagatggc gggacgctgg ggcagggcac actggcggag 4583 ctgcttgctc agtagggaat gtcagttgtt gcgctgggcc atgagaaatc cgccagaaaa 4643 cgttaggtga gcagacatgc cccccatgcc agtgggctgc tgtgagtgag gataaggtgt 4703 gtgttgggca tagaaaccct ggctgcccgc ccaccctgtg gagacaagtg cagctcctcc 4763 agctggagag gctgccctct ctcctgccca cttccctccc ttctccatga tttccatgga 4823 gacctgtggc tctgctcacc cctggcatgc agaccgctct cccgtccagc cctaagcctg 4883 ctctgcggag ggc ggggtca ttcttctcct ggagatttca gtgggactcg tccccagtgg 4943 gcacaacaca gcccttggtg ggaggggaag gccccagcct cctccacctc ccactggaaa 5003 gcagactgct tgggactgcc cagctgtgaa ttgtatagtt tctgtactta ttagaactgg 5063 gtaaattatt ttggttcaaa tctattattc catcaattca gttagaattg aattttctag 5123 gtgattatgc agaatcttct gccagggcac gatgctgtcg taagagattt ctgttctctg 5183 tactgggccc ccttgccctg ttccttgagt gaagtggggg ctgccctcac ctgtccccct 5243 tgcctgtgaa tcccttcctt gtacatggtg gtcagtggca cggaatcccc aatagattgt 5303 atatctgaag gagaaaaata aacacttttg ctcg 5337 <210> 76 <211> 5833 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (283) .. (2988) <400> 76 gtctcaacat gactgactgg gaagcggtgg ctcgggcaga gcagctccgc tggcgcaggc 60 aggaggagca ggaggattat taaataacgc agctggactc tgtgcaactg ggagtggaga 120 ggagcccaac agccgagaag gggagggagg gcagaggagg gggaccagga aggacacccc 180 cgtgccccga agacataaat ccctgagtgc ccgggaggag ccttaacaag cgcacggagc 240 cctcaaggct gcaaagttgg ctttcacagt gcaagccttt ga ttc cca atg ggg 294 Phe Pro Met Gly 1 gac tca gga tca aga cga tct acc ctg gtc tcc cgg ttg cca ata ttc 342 Asp Ser Gly Ser Arg Arg Ser Thr Leu Val Ser Arg Leu Pro Ile Phe 5 10 15 20 aga aga agt att aac aga aga cat gat tct ctt cct tct tca cct tct 390 Arg Arg Ser Ile Asn Arg Arg His Asp Ser Leu Pro Ser Ser Pro Ser 25 30 35 tcc agt aat aca gtt ggt gtc cac agt tcc tct cct tcc agc act aac 438 Ser Ser Asn Thr Val Gly Val His Ser Ser Ser Pro Ser Ser Thr Asn 40 45 50 tca agc tca ggt agc aca ggt aaa cgg agg agc ata ttc cgt act cct 486 Ser Ser Ser Gly Ser Thr Gly Lys Arg Arg Ser Ile Phe Arg Thr Pro 55 60 65 tcc att agc ttc cac cat aag aag ggg agt gag cct aag caa gag c ct 534 Ser Ile Ser Phe His Lys Gly Ser Glu Pro Lys Gln Glu Pro 70 75 80 acc aac cag aac ctt agt att tca aat ggt gct caa cct ggt cac agc 582 Thr Asn Gln Asn Leu Ser Ile Ser Asn Gly Ala Gln Pro Gly His Ser 85 90 95 100 aat atg cag aaa ctg agt ttg gaa gaa cat att aag acc agg gga aga 630 Asn Met Gln Lys Leu Ser Leu Glu Glu His Ile Lys Thr Arg Gly Arg 105 110 115 cat tct gtt ggt ttt agt agt tca cga aat aag aag ata aca aga tct 678 His Ser Val Gly Phe Ser Ser Ser Arg Asn Lys Lys Ile Thr Arg Ser 120 125 130 ttg aca gag gat ttt gaa agg gaa aaa gag cac tca act aac aag aat 726 Leu Thr Glu Asp Phe Glu Arg Glu Lys Glu His Ser Thr Asn Lys Asn 135 140 145 gtc ttt ata aat tgt cta agt tct ggc aaa agt gaa ggg gat gat tct 774 Val Phe Ile Asn Cys Leu Ser Ser Gly Lys Ser Glu Gly Asp Asp Serp 150 155 160 ggt ttc aca gaa gac caa act cgt cgt tct gtt aag cag tca aca agg 822 Gly Phe Thr Glu Asp Gln Thr Arg Arg Ser Val Lys Gln Ser Thr Arg 165 170 175 180 aag cta ctc cct aaa tct ttt tca tct cac tat aaa tt t tct aag cca 870 Lys Leu Leu Pro Lys Ser Phe Ser Ser His Tyr Lys Phe Ser Lys Pro 185 190 195 gtt cta cag agc caa tcc att tca ttg gta caa cag tct gaa ttc tca 918 Val Leu Gln Ser Gln Ser Ile Ser Leu Val Gln Gln Ser Glu Phe Ser 200 205 210 ttg gaa gtt aca cag tac caa gag aga gaa cct gta tta gta aga gct 966 Leu Glu Val Thr Gln Tyr Gln Glu Arg Glu Pro Val Leu Val Arg Ala 215 220 225 tcg cca tcc tgt tct gtg gat gta aca gaa cgg gca gga agc tct tta 1014 Ser Pro Ser Cys Ser Val Asp Val Thr Glu Arg Ala Gly Ser Ser Leu 230 235 240 caa tct cct ttg ctt tct gct gat ctt acc aca gct cag aca cct tca 1062 Gln Ser Pro Leu Leu Ser Ala Asp Leu Thr Thr Ala Gln Thr Pro Ser 245 250 255 260 gaa ttt tta gcc ttg act gaa gat tct gtg tct gaa atg gat gca ttt 1110 Glu Phe Leu Ala Leu Thr Glu Asp Ser Val Ser Glu Met Asp Ala Phe 265 270 275 tct aaa agt gga agc atg gca tcc cac tgt gac aac ttt ggc cac aat 1158 Ser Lys Ser Gly Ser Met Ala Ser His Cys Asp Asn Phe Gly His Asn 280 285 290 290 gat tct acc tct cag atg tcc ctc aat tct gct gct gtt aca aag aca 1206 Asp Ser Thr Ser Gln Met Ser Leu Asn Ser Ala Ala Val Thr Lys Thr 295 300 305 aca aca gaa ctt acg gga act gtt ccc tgt gca att atg tct cct ggg 1254 Thr Thr Glu Leu Thr Gly Thr Val Pro Cys Ala Ile Met Ser Pro Gly 310 315 320 aaa tat agg tta gag ggt caa tgt agc act gaa tct aat tca tta ccg 1302 Lys Tyr Arg Leu Glu Gly Gln Cys Ser Thr Glu Ser Asn Ser Leu Pro 325 330 335 340 gaa acc tct gct gct aat cag aag gaa gtg tta tta caa att gct gaa 1350 Glu Thr Ser Ala Ala Asn Gln Lys Glu Val Leu Leu Gln Ile Ala Glu 345 350 355 cta cct gct aca agt gtg agc cac tca gag agt cca gca gat 1398 Leu Pro Ala Thr Ser Val Ser His Ser Glu Ser Asn Leu Pro Ala Asp 360 365 370 agt gaa aga gaa gaa aat ata ggg tta caa aat ggt gaa aca atg ctg 1446 Ser Glu Arg Glu Glu Asn Ile Gly Leu Gln Asn Gly Glu Thr Met Leu 375 380 385 ggg aca aac tcc cca agg aaa ctt gga ttt tat gag caa cat aaa gca 1494 Gly Thr Asn Ser Pro Arg Lys Leu Gly Phe Tyr Glu Gln His Lys Ala 390 395 400 ata gcg gaa c at gta aaa ggg atc cat cct att tca gat tca aag ata 1542 Ile Ala Glu His Val Lys Gly Ile His Pro Ile Ser Asp Ser Lys Ile 405 410 415 420 ata cct act tct ggt gat cat cat att ttt aac aaa aca tca cat gga 1590 Ile Pro Thr Ser Gly Asp His His Ile Phe Asn Lys Thr Ser His Gly 425 430 435 tat gaa gca aat cct gcc aaa gtt ctt gcc agt agt ctc agt cca ttt 1638 Tyr Glu Ala Asn Pro Ala Lys Val Leu Ala Ser Ser Leu Ser Pro Phe 440 445 450 cgt gaa gga aga ttt ata gag agg aga ctg cga tcc tcg tca gaa ggc 1686 Arg Glu Gly Arg Phe Ile Glu Arg Arg Leg Arg Ser Ser Ser Glu Gly 455 460 465 act gca ggg agt atg atg atg ttg aaa ccg aaa gat gga aat ata 1734 Thr Ala Gly Ser Ser Arg Met Ile Leu Lys Pro Lys Asp Gly Asn Ile 470 475 480 gaa gaa gtt aat agt tta aga aag caa aga gca ggt tct tca tct tca 1782 Glu Glu Val Asn Leu Arg Lys Gln Arg Ala Gly Ser Ser Ser Ser 485 490 495 500 aaa atg aac agt ttg gat gtt ttg aat aat ttg gga tct tgt gaa ctg 1830 Lys Met Asn Ser Leu Asp Val Leu Asn Asn Leu Gly Ser Cys Glu Leu 50 5 510 515 gat gaa gat gat cta atg ctt gat ctt gaa ttt tta gag gaa cag agt 1878 Asp Glu Asp Asp Leu Met Leu Asp Leu Glu Phe Leu Glu Glu Gln Ser 520 525 530 ctt cac cct tct gtt tgc cgg gag gac cac tct gtc gtc tca 1926 Leu His Pro Ser Val Cys Arg Glu Asp Ser Tyr His Ser Val Val Ser 535 540 545 tgt gcc gca gta gtt ctt act cct atg gaa cca atg ata gaa atg aag 1974 Cys Ala Ala Ala Val Val Leu Thr Pro Met Glu Pro Met Ile Glu Met Lys 550 555 560 aaa aga ga gaa gaa cca gaa ttt cct gag cct tcc aaa cag aat ctt tcc 2022 Lys Arg Glu Glu Pro Glu Phe Pro Glu Pro Ser Lys Gln Asn Leu Ser 565 570 575 570 ctg tta aca aag gac gtt gat caa gaa gcc agg tgt tcc cac atc 2070 Leu Lys Leu Thr Lys Asp Val Asp Gln Glu Ala Arg Cys Ser His Ile 585 590 595 agc cga atg ccc aac agt cca tct gcg gat tgg cct cta cagtt 2118 Ser Arg Met Pro Asn Ser Pro Ser Ala Asp Trp Pro Leu Gln Gly Val 600 605 610 gaa gaa aac gga ggc ata gat tct ctg cca ttc aga ctg atg tta cag 2166 Glu Glu Glu Asn Gly Gly Ile Asp Ser Leu Pro Phe Arg Leu Met Leu Gln 615 620 625 gac tgc acg gca gtc aag acg tta tta tta aag atg aag aga gtt ctt 2214 Asp Cys Thr Ala Val Lys Thr Leu Leu Leu Lys Met Lys Arg Val Leu 630 635 640 640 caa gag agt gca gat agt cca gca agc agt acc acg tca ctt cct 2262 Gln Glu Ser Ala Asp Met Ser Pro Ala Ser Ser Thr Thr Ser Leu Pro 645 650 655 660 gtt agt cct ctt act gaa gag cca gtg cct ttc aag gat ata atg aaa 2310 Val Ser Pro Leu Thr Glu Glu Pro Val Pro Phe Lys Asp Ile Met Lys 665 670 675 gat gaa tgc tcg atg ctc aag ctg cag ctg aaa gag aag gat gaa ctc 2358 Asp Glu Cys Ser Met Leu Lys Leu Gln Leu Lys Glu Lys Asp 685 690 att tcc caa ctt cag gaa gag ctg gga aaa gtc cgg cat tta cag aag 2406 Ile Ser Gln Leu Gln Glu Glu Leu Gly Lys Val Arg His Leu Gln Lys 695 700 705 gct ttt gct tca aga gta gat aaa tcc aca cag act gaa cta cta tgc 2454 Ala Phe Ala Ser Arg Val Asp Lys Ser Thr Gln Thr Glu Leu Leu Cys 710 715 720 tat gat ggt tta aac ttg aaa aga cta gag aca gta caa gga ggg aga 2502 Tyr Asp Gly Leu Asn Leu Ly s Arg Leu Glu Thr Val Gln Gly Gly Arg 725 730 735 740 gag gct aca tat cga aat cga att gtg agc caa aat ctc agc aca agg 2550 Glu Ala Thr Tyr Arg Asn Arg Ile Val Ser Gln Asn Leu Ser Thr Arg 745 750 755 gac aga aaa gca ata cat act ccc acc gag gac cgt ttt agg tat tcg 2598 Asp Arg Lys Ala Ile His Thr Pro Thr Glu Asp Arg Phe Arg Tyr Ser 760 765 770 gca gcg gac cag aca agc ccc tac aaa aac aag acc tgt caa ctc cca 2646 Ala Ala Asp Gln Thr Ser Pro Tyr Lys Asn Lys Thr Cys Gln Leu Pro 775 780 785 agt ctc tgt tta agt aat ttc ctg aag gac aag gaa cta gca gaa gtt 2694 Ser Leu Cys Leu Ser Asn Phe Leu Lys Asp Glu Leu Ala Glu Val 790 795 800 atc aaa cat tca aga gga act tat gaa acc ctc act tca gac gtt aca 2742 Ile Lys His Ser Arg Gly Thr Tyr Glu Thr Leu Thr Ser Asp Val Thr 805 810 810 815 820 cag aac tta cgg gcc acc gtt ggg cag agc tct ctg aag cca aca gct 2790 Gln Asn Leu Arg Ala Thr Val Gly Gln Ser Ser Leu Lys Pro Thr Ala 825 830 835 aag aca gaa ggg ctc tcc acg ttc tta gag aaa cca aag gac caa gtt 2838 Lys Thr Glu Gly Leu Ser Thr Phe Leu Glu Lys Pro Lys Asp Gln Val 840 845 850 gct acg gcc cga cag cat tcg acc ttt aca ggc agg ttt gga cag cca 2886 Ala Thr Ala Arg Gln His Ser Thr Phe Thr Gly Arg Phe Gly Gln Pro 855 860 865 ccc aga ggg cca atc tct tta cac atg tac agc agg aag aat gtg ttt 2934 Pro Arg Gly Pro Ile Ser Leu His Met Tyr Ser Aru Lys Asn Val Phe 870 875 880 ctc cac cac aat tta cac agc act gag ctg caa act cta ggc cag cag 2982 Leu His His Asn Leu His Ser Thr Glu Leu Gln Thr Leu Gly Gln Gln 885 890 895 900 gat ggg taattaaatc accgtattcc tgtctttggg taggataaag atggttattg 3038 Asp Gly tttctcgtgc atagtttgttcat gtt ag 3158 tttccaagag tgaaagtttg agcatgttaa ttgaactagg ttgcattgcc ttgaagactt 3218 tactatatag gtgtataata aatgggacca tcatgatcgt ttatatagtc cataatttat 3278 ttatttttta tctctatatcag tatgat tccat tagcat gattaagtg tcatagatg tcatcattagtg tcatg aatagataa 3398 aggaattata aagaatttta aattatataa ttaatagaag gaggaaaaaa gagaaatgtt 3458 aacgtcttat atttggtggt atatttattt gaagaatgtg gcttgcttgc atgtaaccta 3518 gagatgtgtt tgtctctatt acatacattc aagctcatct tgtgatacta gtaaggggga 3578 aatggctgta ttttttttcc tttaaacgtt tagttcatac tagttcacaa aggatttcag 3638 acagagtaat tgctagccaa atagagaatg acagctctga tctttgaaaa attttgcttt 3698 tagtttttgt tattgatgtt gaagtaccgt gacataacac aaggtgataa agttggttga 3758 attttgtcag atgatgcata aatactgaca tgctatattc tttgagccac tgtcatggca 3818 atataaacat tttttcaaaa tttcaaggat gaaacatcct aagaaaatta ttctttttct 3878 ttactttcct tattttttaa aatgttcttt tttatgtaaa tccaattttg gtttatatac 3938 atcaacccat atctataatt ttatgaactg aagaacagaa agtcagtatt ttagtagcca 3998 gcatacaata ttctgactat gcagaaatct agatttggaa caaaagtaaa gtaaatgtga 4058 acattggcaa tttaatctta gaaataagct tctaacagga atatttaaaa cccatttgat 4118 ggcaaatatt tctctttgac aaataaggcc caaatatgtt ataatatgtt atatacttat 4178 gtgcacttta gatcaatata tgaattgatc tatggataat tccatcatgt tcaatta gta 4238 gcagagcaga atcaaagagt acaattaaat acataaataa ataattttta aaagactaat 4298 aggaatcaag gctgcagttt tcttatacac atcagagctg ttaagtacat ccacattagc 4358 catagtccat gcaaattgaa actgtcatac ctactgcatg atctgtttcc cttgcatttt 4418 ctaacagaat ctgtcagcgt gcacaagcaa gatgaacaaa gggaaattga gatagcagtt 4478 ttagcatggc atctgacaac ttgcttaaat taaagctgtg tgcaaaatgc atctcctatt 4538 ataaaaatgt atttgtgccc tgtgctttgg ggaaaagcca ttagacactc cacccctgag 4598 ctttaactac tgaactttga tacatttgca aacttagatt ggaactgata aagtaaggag 4658 tcgagtggat atgttgtact tgtaattttg gttttccaaa ggaacacaca tgtgcatcaa 4718 ggcagacatt tgccaaatgt tttctttctt tgcgtgtttg taattctgcc aaaagagaac 4778 aatatacact gcaaattgct tgacttaatg agattgccat ctaaagttcc caccatactt 4838 tggaagctat aatgatcatg cagatataca ctttgggctg ggcaatattt aagaaatgat 4898 aggaaaatag aaaaatcatg attattaatt gtggaattca gcttgatttg tcctaaatgt 4958 tggtgtctgt tgctagagta ttttaaatct gtacataaat aagcatgata aaataatcaa 5018 ggattttttc ccaggatatg gaagaactat gtatcacaaa taatgttttt gatttggact 5 078 tttggagttg atagttttgt tttcctggaa gatagacttt tgaattatac tttataaaaa 5138 taatctattt atagaagatc tgtcatttaa tagacatttt aagagatgtt ttaaacgcta 5198 gtattttctt gaaaaatctt ttttaaagct gaatcattca aaagaaaacc tggattaaac 5258 agttcgattt taaaaggaag ggtatttttt ggaaatatca tcttaaagct gttttgtatc 5318 agtattttca acattgttat aatattattt gtaatactaa gtgtaactca ggcctggaga 5378 aggtgtaagc ccactatgct aatgtacatc agtaactgta aaacaggggt tctttgtaag 5438 ttcctcttgt gtatatatag taacttataa caatggcatg tgggcattct ttcagtgaat 5498 tgctttcttt gtactaaaat ctctagtttt ctaagacagt tccatgtata aaaatgattt 5558 atgcctttct ccaaggcggt acatatccaa agacatgaca ccagggggaa aaagtgcttg 5618 tttttctgat ggaagcagtg gtcttttctt ttctttcctc tttcttttgt gcatgtgtat 5678 gtgtagctaa gcctaaataa ccctgtaaaa tttctgctgc aaattgtctc ttctgaattt 5738 agaatgtgtt ttaaaggaac acttaggaag agaaatacct tgaagaaaag ctgtttccac 5798 ctgaaataaa ctgttcccat ttttataatt attgg 5833 <210> 77 <211> 5142 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1440) <400> 77 gaa gaa tat gaa cag gat gag aga gac cag aaa gag gag gga aat gat 48 Glu Glu Tyr Glu Gln Asp Glu Arg Asp Gln Lys Glu Glu Gly Asn Asp 1 5 10 15 tat gac act cga agt gag gcc agt gac tct ggt tct gaa tct gtt tcc 96 Tyr Asp Thr Arg Ser Glu Ala Ser Asp Ser Gly Ser Glu Ser Val Ser 20 25 30 ttc aca gat ggg tct gtc aga tct ggt tca ggc aca gat gga tca gat 144 Phe Thr Asp Gly Ser Val Arg Ser Gly Ser Gly Thr Asp Gly Ser Asp 35 40 45 gag aaa aag aag gaa agg aag aga gct aga ggc ata tct cca att gtt 192 Glu Lys Lys Lys Glu Arg Lys Arg Ala Arg Gly Ile Ser Pro Ile Val 50 55 60 ttt gat aga agt gga agc tct gca tca gag tca tat gca ggt tca gaa 240 Phe Asp Arg Ser Gly Ser Ser Ala Ser Glu Ser Tyr Ala Gly Ser Glu 65 70 75 80 aag aag cat gag aaa tta tca tct tcc gtt cgt gct gtc cga aaa gat 288 Lys Lys His Glu Lys Leu Ser Ser Ser Val Arg Ala Val Arg Lys Asp 85 90 95 caa acc agt aaa ctc aaa tat gtg ctt caa gat gca aga ttt ttc ctc 336 Gln Thr Ser Lys Leu Lys Tyr Val Leu Gln Asp Ala Arg Phe Phe Leu 100 105 110 ata aag agt aac aac cat gag aat gtg tct ctt gcc aaa gcg aag ggt 384 Ile Lys Ser Asn Asn His Glu Asn Val Ser Leu Ala Lys Ala Lys Gly 115 120 125 gta tgg tcc acg ctc cct gta aat gag aag aaa tta aat ctt gca ttt 432 Val Trp Ser Thr Leu Pro Val Asn Glu Lys Lys Leu Asn Leu Ala Phe 130 135 140 aga tct gca agg agt gtt atc tta ata ttt tct gtc aga gag agt gga 480 Arg Ser Ala Arg Ser Val Ile Leu Ile Phe Ser Val Arg Glu Ser Gly 145 150 155 160 aaa ttt caa ggg ttt gca aga ctt tct tca gaa tca cat cac gga gga 528 Lys Phe Gln Gly Phe Ala Arg Leu Ser Ser Glu Ser His His Gly Gly 165 170 175 tct cct ata cac tgg ggt ctt cca gca gga atg agt gct aaa atg ctg 576 Ser Pro Ile His Trp Val Leu Pro Ala Gly Met Ser Ala Lys Met Leu 180 185 190 gga ggt gtc ttt aaa att gac tgg att tgc agg cgt gaa tta ccc ttc 624 Gly Val Phe Lys Ile Asp Trp Ile Cys Arg Arg Glu Leu Pro Phe 195 200 205 act aag tcg gct cat ctc acc aat cct tgg aat gaa cat aaa cca gta 672 Thr Lys Ser Ala His Leu Thr Asn Pro Trp Asn Glu His Lys Pro V al 210 215 220 aag atc gga cgt gat gga cag gaa att gaa ctt gaa tgt gga acc cag 720 Lys Ile Gly Arg Asp Gly Gln Glu Ile Glu Leu Glu Cys Gly Thr Gln 225 230 235 240 ctt tgt ctt ctg ttt ccc ccc gat gaa agt att gac ttg tat cag gtc 768 Leu Cys Leu Leu Phe Pro Pro Asp Glu Ser Ile Asp Leu Tyr Gln Val 245 250 255 att cat aaa atg cgt cac aag aga aga atg cat tct cag ccc cga tca 816 Ile His Lys Met Arg His Lys Arg Arg Met His Ser Gln Pro Arg Ser 260 265 270 270 cga gga cgt cca tcc cgt cga gaa cca gtc cgg gat gtg gga agg cgt 864 Arg Gly Arg Pro Ser Arg Arg Glu Pro Val Arg Asp Val Gly Arg Arg 275 280 280 cga cca gaa gat tat gat att cat aac agc aga aag aaa cca agg att 912 Arg Pro Glu Asp Tyr Asp Ile His Asn Ser Arg Lys Lys Pro Arg Ile 290 295 300 gac tat ccc cct gag ttt cac cag aga cca ggg tat tta aag gat cca 960 Asp Tyr Pro Pro Glu Phe His Gln Arg Pro Gly Tyr Leu Lys Asp Pro 305 310 315 320 cga tac cag gaa gtg gac aga cga ttt tca gga gtt cgc cga gat gtg 1008 Arg Tyr Gln Glu Val Asp Arg Arg Phe Ser GlyVal Arg Arg Asp Val 325 330 335 ttt tta aat ggg tcc tac aat gat tat gtg agg gaa ttt cat aac atg 1056 Phe Leu Asn Gly Ser Tyr Asn Asp Tyr Val Arg Glu Phe His Asn Met 340 345 350 gga cca cca cca cct tgg caa gga atg ccc cct tac cca gga atg gaa 1104 Gly Pro Pro Pro Pro Trp Gln Gly Met Pro Pro Tyr Pro Gly Met Glu 355 360 365 caa cct cca cac cat cct tac tat cag cac cat gct cca cct cct caa 1152 Gln Pro Pro His His Pro Tyr Tyr Gln His His Ala Pro Pro Pro Gln 370 375 380 gct cat ccc cct tac tca gga cat cat cca gta cca cat gaa gca aga 1200 Ala His Pro Pro Tyr Ser Gly His His Pro Val Pro His Glu Ala Arg 385 390 395 400 tac aga gat aaa cga gta cat gat tat gat atg agg gtg gat gat ttc 1248 Tyr Arg Asp Lys Arg Val His Asp Tyr Asp Met Arg Val Asp Asp Phe 405 410 415 ctt cgt cgc aca caa gct gtt gtc agt ggc cgt aga agt aga ccc cgt 1296 Leu Arg Arg Thr Gln Ala Val Val Ser Gly Arg Arg Ser Arg Pro Arg 420 425 430 gaa aga gac cgg gaa cga gag cga gac cgc cct aga gat aac aga cga 1344 Glu Arg Asp Arg Glu Arg Glu Arg Asp Arg Pro Arg Asp Asn Arg Arg 435 440 445 gac aga gag cga gat aga gga cgt gat aga gaa aga gaa aga gag cga 1392 Asp Arg Glu Arg Asp Arg Gly Arg Asp Arg Glu Arg Glu Arg Glu Argtta 450 455 tgt gat cga gac aga gac cga ggg gag aga ggt cga tat aga aga 1440 Leu Cys Asp Arg Asp Arg Asp Arg Gly Glu Arg Gly Arg Tyr Arg Arg 465 470 475 480 480 tatg tt tt gg ttggacc tgattg ttg gaaggattta ttatgacccc ctttgttcca agcatgcagt atcataagaa ctggaaaaac 1620 tcaaatccgc caaaaatcca cagctgacag ttgaattgac acttttattg gggcagaatg 1680 gaacagtcca agaatgtaga tactgattct ttctccataa atgttcttat agtgtgttca 1740 tcctagagtt atttttttgt ttgttttttt cctttttgga tcttgattga taactgccat 1800 gatattttgc tttgatgtgt ttctacatgt agttgcacac ggttcagtaa aaataatgct 1860 gctatcgagt atgcaaatat tgaagtatga tggtttgact gtatggcagt gttgtagcag 1920 cctcttgttt ttttccccat tgcctctttt tttaaaaaac ttataaagtc actttttatt 1980 tttcctcagt ctt caatgac gagagcaata ttaagaagac attgctatct aatttttaat 2040 ctttttaaat gaaaaattcc tatgttcagt agcgtggttg atgctattgt ttagccttcc 2100 cctccaaatt gtatacattg gcttggaatg ttcacaactt gcgtgcgtgg cagcggaaga 2160 cgattcccat attctacatt gctactgttt tgtataaaat aaattggtaa agattgacgg 2220 ttatcttttg tatctttttc ttatccaatt gcaggtttgt tttattatgc aataatggac 2280 ataaaagcat gctttttgtt caggaatttt aggaacccca tttgcttttt ttgaggcacg 2340 ctttagcaga aatgattgac ctaggcctgt tgcattaaaa gcttacttct atttctaaca 2400 taagatacac agagttatgt taataatttg gttaagtatt tatacacctg ataacatttt 2460 gagtctactc tgatcacaga atcgtttatt taggttttct atttgttgtt ttagtcttct 2520 gtaagtgaac gactttgtac atgctttcta ctttacttca taaatggact tttaaccctc 2580 ttgtattagt tctgtatttt aagttaactg tccagttctc ccagtggtaa ccaactataa 2640 catagaaata gagccgctca agaaaacagt ttatgaaata atttttttga attttttctt 2700 gagttacacc tggagttttg gcctttggaa tttggccttt ataaacatta ggaatatttg 2760 aatgtttgat ttttttatag tatcaacagt tgtactgtgt accagatcac atagtacagt 2820 tttacattta atctatatt g gcctgaaaag aacaacacag gcactttact cttaaaggat 2880 ataataaact atagttatac tgcattcata ttcataccag catgtagtat ctttccctgc 2940 attcacagaa gttttattta caatgacaaa actaaagcct gaggatttgt tttaaatctg 3000 cattgtggta gagaggaaaa agtactttta aggaaacctg ggttctagtt ttgtcattgt 3060 ctttaattaa accggttagt gatacatggt aagtcacttc attggcattt tgtgtattca 3120 tcagtaagct agacaagatg atagctacag tttaagaatt tctgtaacca ttatacaaaa 3180 ctggtaggta atattaaagg tattttcctg aaataatagg aataaatact gagcactttg 3240 tatgcaatag agactttgtg cttttatata cagactcatt taaatgggct cagagaggct 3300 agtaaacttg cccaagatta gaaaggtagt aattgatggg ccaagatttt acccatgttt 3360 ttatttggtg tttctaaacc acctcatcac ttttgaaaaa acagtatata aattaataaa 3420 tgttttggag atggagtctg tcgcccaggt ggagggcagt ggcatgatct tggctcactg 3480 caacctcctg cctcagcctc ccgaatggct gggactacag gcacccacca ccacaccccg 3540 ctaatttttg taattttagt agagatgggg ttccaacatg ttggccaggc tggtctcaaa 3600 ctcgacctca agtgacctca cctgcctcag cctcctaaag tgttgggatt acaggcgtga 3660 gccactgcac ctggcctgag att tttaaac attaacattt ccttcaggct taagcagagg 3720 atttttctaa agtgccatcc aattagatgt taagttatgc tttgtatgtt gagcttagta 3780 ttgagtcgat ctattttaaa aagccaacat taagttttta ccaagtatct ggcactattc 3840 taaacaattc tcttggctca cataatcatc actgttttct cctttcctaa tttttaaaat 3900 aaacttaccg gaacattgta taaaaaatgc aagatttttt tctgtacaga agagtcagta 3960 tataaaaatc agtatgtttt atttaatatt cgtacacatg acagcttttg tcactgtgag 4020 aagacatggt ttctttcgtg tactccactg tgctgtgatt ctaacaatct acattagtat 4080 gatgtgttca gatgaaaaac agaaaattca gtcattccga gtttagaaat ccggtcaggg 4140 attttattgg ctggagtaat agttcaaagg agtgaaaatt caagcatgta atttttggat 4200 ttgatttcct ccataatgat ttcctccata atggcttttt ttcaagcatg gtctaatttt 4260 tcagaaaatg gccattatct ccaagcttcc attgtccatg tagtttcagt ggcaggagag 4320 agactatttt cctcccagtg tccatgtcag ttccccaaaa ggactgaata gccatgttgg 4380 ttttggagcc agccgtaatc caatctgtat ttccaaggaa atggggttct ttgtctccca 4440 gcattgggaa gcaagagagg cgcatgttat ggtcacctct gtgaggatta catcaggaag 4500 gacagtctcc aaaagacatg gacagagga a atttagcaga tgtccattaa atcaggatct 4560 catacaagtt ataacacctg aatgtttgac ttttcagagt attttgccat cacaggtgtg 4620 gcatcttgcc cttggatata tctacattct gctgtagaat gtcgtggtct ttctgagggt 4680 cacatacatc ctgtcttgtc ataatgttaa ccattaagag tcctcagggg catggaattg 4740 aagaaggaac tgttgccagc agttaactga ccaagctaga gttccctgac ccaacgtaag 4800 ggtgactgtg acacacatgg ataattttag cttcatgttt aagattttgt tatttgggta 4860 ggaaacattc caaatgcagt ttgaaacaca tattaaaatt gaggcacaca ggaaagaact 4920 ggctcaagtt tagtccccaa gttccttata gtaggaatag gaatccttag agtataagca 4980 atccatgcat agtattctgt tatctatcat gtagatcatt taatctctaa ttttttgggg 5040 tggggattct cttgtttcta aatcttacac tttcagtttc ttctgtgtct taaatataga 5100 ttattgactg ttgtataaatcat tactat ttgttaaa <210> 78 <211> 5181 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2582) .. (3160) <400> 78 gtttcactat gttggctagg gtggtctcga actcctgacc tcgtgatccg cctgccttgg 60 cctcccaaag ggctgggatt acaggcgtga gccactgcac ctggccaatg aagagctctt 120 tattgtgtgt gtgttttgga aggaaaaaga ctcttccaac tcacatctca ttggccaaaa 180 tcaggccaca tggtcgctct ctggcagtaa agtttagcta ttccctgaga gcctatggca 240 gcgtaactga ttgcatttga ctaagtattt agggtgcatg gatgtttggc aatcagccta 300 acctctcgct gcagtgtcct gcttgagggc ctcaccctct accccaagtg gcttctcaga 360 atattccttc tgaccacata cagtgccccc ttagacttgt gccctgaaca cctcccctgg 420 gtccggagga atcactgaca tatcagcagt tggatgtcca gcattttgct gttgaccctc 480 cctcttggag ctgtttttct ctcccgctat ttcccctact ctttgcccca tgctgtacgg 540 tggccgcggt cacaaatgcc acaggcagtg ccctgactca gcttgtgtgg ggagccactt 600 ccccagcctc catctgtcag ctgtggtccc acaagagatg gaaaaaatta ttcagcatgc 660 actagatgct cacaagggcc atgattccct gatcttcata cttttcattt cttgaacttg 720 aacaacgagg actttaggtt gctcacgcta agccacatgt tcctaaatgt acaggatttt 780 tctaggctgg caagggagac ctgtgaccca agctgagtcc acgtgaagag gacctagggc 840 ttaagtccat c atgctaggc caccttgagc cagccccttc tgtgaaccca ttaacccagt 900 agacagactc aatcagtcag agagcggata catggcatga gcaccactac cagccacatg 960 gtgctcacgg cagattttac taatcaatca cagactcttt ccctctgaac ttgcattggt 1020 gctagaatcc tcttcactcc agctccctcc acagcctcca tgaacttatc agtgagaagc 1080 acgcagtttc gactcttcca tctgccatcc tgatcaggat tgttaatgtc cctcccaact 1140 ctcaggtctt cagcccagtt agctttcaaa tctttggctt ctccctgcct tctctacctt 1200 ctgaaaagga actttgggct ccgttttccc tcatattcct cctgaagact ctgtcctgtc 1260 acgggatttc agagatttac atccctgctc ttatactctc tagctatgtg gctttggcaa 1320 gtttcataac ctcagtgagc ctgtttccac atctgtaaaa cgggaccagc atctgccttg 1380 agaagtgaga acgtgcctgg cagggcacca gccatgtggg accacacact agtccctgcc 1440 cttgcacagc ctgctctggg ctctgccagg gaaatcaatc aaggattttg atggggaaaa 1500 aaaatgacac aatcagccat tacttgacaa aattttactt tagcccttgc atctccctgc 1560 caggctgccg gacagctccc ccgacacccg acccaggagg cagcctgatc ccaccttgtg 1620 ctttggtagg ggacatccct cacccctctc tcccaggaga ccagggccaa cgtaccttga 1680 gagtctgtaa acctacgc ca ggactggggt taacacccca gcccaccagc tgagtctgcc 1740 aggacacggg gctctgggaa gctctgaacc cctcccatgc cccagatcct gtgccaccca 1800 cacccacacc actcaggact ctggaaggag gtgagcgggg accataccaa gaccccagag 1860 gtgcctgtgg agagcagggc ttgctggggg gaagacaatg aagcagccaa ggatccctct 1920 cgaggggctc tgtctctggc tgtgcttctc cagcccaagc tgcccctctc cccgggggca 1980 gtgacaactg ttcccccaga gcaagtccag agtcacagac cgtatcccct cccaccagca 2040 aacaggaaac taaagcagtg aaaacatcaa gctttgttgc cagagaaaaa aaaatgaacc 2100 ctaagtattt aaaattcaga cggaagtccc agcccaccgg gccagccgtg agctgcagag 2160 gccttgattg cagacacaca cccctccata tttccccaag ctcaagggtc tccagagaca 2220 gaaggaaggg gttttgggct gagtctgtca ccaagaggca gcgtttggga aaatcaaggt 2280 cagggtggag gtgtcctcag ggggccaccg gtgtggggca ctgaggactg taaacatgac 2340 ccagggtgag ggccaggagg tgtcccagcc ccgaggttct ccctggatga aaaatgggca 2400 ctgtggtgag aagaaagggg accggcggtc agccccgaag ccaagcaaga cctggtcccc 2460 accaggagta tgggggtggg ggctgagctc aggaggggac atgttagagg gggctgcctg 2520 gagctgaaga ggggctctgg aa gccacact cggtgtgcgg ctgttttttc tccgccacta 2580 g gtc agc acc tgg gcc ttc cta ggc ggt gag tca gct ggt ggc ctc ccc 2629 Val Ser Thr Trp Ala Phe Leu Gly Gly Glu Ser Ala Gly Gly Lec Pro 1g 15 ct g agg tca cct cgg gcc atg gct acc cag 2677 Ser Leu Gly Glu Pro Ala Arg Arg Ser Pro Arg Ala Met Ala Thr Gln 20 25 30 ccc agg aag gga ggt cag gca agc tcc caa ggg gcc cca ggc cca ggg 2725 Pro Arg Lys Gly Gly Gln Ala Ser Ser Gln Gly Ala Pro Gly Pro Gly 35 40 45 gcc aag act gaa gga tgc agt caa gga gtg tct gga gag ccc tgt gag 2773 Ala Lys Thr Glu Gly Cys Ser Gln Gly Val Ser Gly Glu Pro Cys Glu 50 55 60 agc cac cac gga gac aca gac agg gcc cgc ggc cag aga gcc act gcc 2821 Ser His His Gly Asp Thr Asp Arg Ala Arg Gly Gln Arg Ala Thr Ala 65 70 75 80 acc agg agc acc acc atg agg cct ggc agg gga ctt ttg gca gag tcc 2869 Thr Arg Ser Thr Thr Met Arg Pro Gly Arg Gly Leu Leu Ala Glu Ser 85 90 95 tgc ctc agc cag ccc agg cca gga gcc ccg agg acc agg cca cct cac 2917 Cys Leu Ser Gln Pro Arg Pr o Gly Ala Pro Arg Thr Arg Pro Pro His 100 105 110 cct tcc ggt cct gca cta aca cct gca cct gtg tcc cca gtc act acc 2965 Pro Ser Gly Pro Ala Leu Thr Pro Ala Pro Val Ser Pro Val Thr Thr 115 120 125 ctc cca gcc acc gtc ctg ctc ctg gag gca ggc agg cac aga gcc agg 3013 Leu Pro Ala Thr Val Leu Leu Leu Glu Ala Gly Arg His Arg Ala Arg 130 135 140 cca gct cct ctg gca ggt ccc gga gca agg cca ggc ccagt gct 3061 Pro Ala Pro Leu Ala Gly Pro Gly Ala Arg Pro Gly Pro Gly Val Ala 145 150 155 160 gcc atg acc gat cct ccc tct gtc cac cct gaa ggc ccg gtc agg agc 3109 Ala Met Thr Asp Pro Pro Ser Val His Pro Glu Gly Pro Val Arg Ser 165 170 175 tgc act aac tgt gca ttt gct ttt cag gcc aca gat cgc cct cag tcc 3157 Cys Thr Asn Cys Ala Phe Ala Phe Gln Ala Thr Asp Arg Pro Gln Ser 180 185 190 cag tgaccctctg agctgcagc ccg gggg 3210 Gln tgcccggcag ctcaggccag cctggggccg gagttctcag gaaacctccc cctcaggccc 3270 tggattctcc ttagtgttgc acgtgacgtt cccctcaagg gtaggccttc tgggtcacat 3330 ggtcctaaag gcccactcag aatccagcac cttctcagag cctgcatccc ccaaaaccag 3390 gccactcagg gcctgggggc cagccttgcc catgatttcc ctcaggatct gctcccccag 3450 tctctccagg acccggcctg tcccagaggg catagagctt gtgtccccct aaaacaggcg 3510 ccctggtggc ctcagggctg gacccggctg ctgagccact ggccacgcag ggcccggatc 3570 tcctggccat agcactcgtg cagccgggcg aagggggcca tgtccagggg cccgtggggt 3630 gccgaggccc ggcggcgagg cggtggtgga gggggctcgg gtccaggcct gaaggtggcc 3690 tcagtgctcc agacagcgca gccattctcc ttgggcggga gggcactggg ccggcggggc 3750 aggggcaggg ctgggaccgg ggctggggca gaaggcaggg atgggactgg ggccagggca 3810 gagggcaggg acgggggcaa gggcagggac tggggctggg gctggggcag ggccatgcca 3870 cgtacagccg ccagctgctg ctccagctcg cgcaccacca gccgcaggta gtcgaagctg 3930 gcacgcgaca gggccttgac ccagccctcc atggcatcct gactctcagc ggccagcacg 3990 taggtgcgcg cccgggtccc cgcaaagcgc acagcgaagg cgaactcctc ggcggcctcc 4050 accagctcca cagtgcagcc ctccaggatg atgacgccca cgggctcacg gctggcagcg 4110 tcctcgaagt agaagagcat gttcccgcgc agcacgaacc agcgccggtg gtaggccgcg 4170 tgccgcccac ccttc ttgta caggaagcct gcattgtcca ccggggcgtc acaggtggcg 4230 tagaaggcca ggctgcgctc gttcagcttc atggtggcaa tcgcggggcc tggaggggag 4290 cctggggcct ggaccccata gaagggctgt tatgcacaag gccactgacg ctaggtcacc 4350 cagtgcccca aggggacctt gcagccactc tacatccccg tttcacagat gaggaaactg 4410 acgctcatag ggtggaagca gctggcctat gcgcccacaa ctcctaagaa gcagagacag 4470 gactggaacc tgggtctcac gggcctcccc agacagcctc ataacctcct accctcctgt 4530 atccctgaaa taatgttgtg agttcctgct gcatgccaga catttcagag gaatgaactc 4590 actttatctc acaatagacc ttaggtcaca gggactggcc tggcaccagt gcaacagatg 4650 aggaaacaga ggcacagaga ggttaactgc ttccctggtg tcacaaagca ggttgggcag 4710 ggctgaaatc caaacccagg cctcatttca ggcgctgctg tttccatcat cccaagaaca 4770 agaccagctg gccttctgca gtccctgcca ggtcccagcc ctgactttgt ggttcgactt 4830 tggtttgttc atccatgaaa tggatgagca gaaccaactt tggagagttg tagagattga 4890 tttcattcat aaaatgttta ttaagcatct actgggtgcc aggcattgtt ccaggcctag 4950 ggatatagca ataacaagat ggacagggtc gaccagcctg gccaacacag tgaaacccct 5010 tctctactaa aaatacaaaa aataagccag gcgtggtggc gggcgcctgt aatcccagct 5070 actcgggagg ctgaggcagg agaatcacct aaacccagga ggcggaggtt gcagtgagcc 5130 gagattatgc cattgcactc cagcccgggc aataatgtga cactctgtct c181 <210> 79 <211> 5034 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (20) .. (2344) <400> 79 gcggagcccc agccgctag tgc tgg tgg ccg ccg ctg ctg ccc cag ctg gag 52 Cys Trp Trp Pro Pro Leu Leu Pro Gln Leu Glu 15 10 ccc gag ccg ccg cct ctg cgt ccg cgc gtc gct gct gct gct Glu Pro Pro Pro Leu Arg Pro Arg Val Ala Ala Ser Gln Gly Gly 15 20 25 ggt atg ctg ggg aaa gga gta gtc ggc ggt ggc ggc ggc acc aag gcc 148 Gly Met Leu Gly Lys Gly Val Val Gly Gly Gly Gly Gly Gly Thr Lys Ala 30 35 40 ccc aag ccc tcc ttc gtg tcg tac gta cgc cct gag gaa att cac aca 196 Pro Lys Pro Ser Phe Val Ser Tyr Val Arg Pro Glu Glu Ile His Thr 45 50 55 aac gaa aag gaa gta aca gag aag gaa gta act ctt cac ttg ttg cca 244 Asn Glu Lys Glu Val Thr Glu Lys Glu Val Thr Leu His Leu Leu Pro 60 65 70 75 ggt gaa cag ctg ctt tgt gaa gcc agc aca gta ctg aag tat gtc cag 292 Gly Glu Gln Leu Leu Cys Glu Ala Ser Thr Val Leu Lys Tyr Val Gln 80 85 90 gaa gat tcc tgt cag cat ggg gtc tat ggg agg ctt gtc tgc aca gac 340 Glu Asp Ser Cys Gln His Gly Val Tyr Gly Arg Leu Val Cys Thr Asp 95 100 105 ttc aag att gcc ttc t tg ggt gat gat gaa tct gca ttg gat aat gat 388 Phe Lys Ile Ala Phe Leu Gly Asp Asp Glu Ser Ala Leu Asp Asn Asp 110 115 120 gaa act caa ttt aag aat aag gtt ata gga gaa aat gac att aca ctc 436 Glu Gln Phe Lys Asn Lys Val Ile Gly Glu Asn Asp Ile Thr Leu 125 130 135 cac tgt gtt gat cag att tat gga gtg ttt gat gag aaa aag aaa act 484 His Cys Val Asp Gln Ile Tyr Gly Val Phe Asp Glu Lys Lys Lys Thr 140 145 150 155 ctc ttt gga caa ctg aag aaa tac cct gag aag ctc atc atc cac tgc 532 Leu Phe Gly Gln Leu Lys Lys Tyr Pro Glu Lys Leu Ile Ile His Cys 160 165 170 aaa gac ctt cga gtg ttc cag ttt agg tac aca aag gaa gag 580 Lys Asp Leu Arg Val Phe Gln Phe Cys Leu Arg Tyr Thr Lys Glu Glu 175 180 185 gaa gtc aaa agg att gtc agt ggc ata att cat cat acc cag gct cct 628 Glu Val Lys Arg Ile Val Ser Gly Ile Ile His His Thr Gln Ala Pro 190 195 200 aaa ctg ctt aaa cga tta ttt ctg ttt tcc tat gcg act gct gca caa 676 Lys Leu Leu Lys Arg Leu Phe Leu Phe Ser Tyr Ala Thr Ala Ala Gln 205 210 215 aac aat a ca gtc act gat ccc aag aac cat acc gta atg ttt gac aca 724 Asn Asn Thr Val Thr Thr Asp Pro Lys Asn His Thr Val Met Phe Asp Thr 220 225 230 235 ctt aag gac tgg tgt tgg gaa ctg gaa cgg acc aaa ggc aac atg aag 772 Leu Lys Asp Trp Cys Trp Glu Leu Glu Arg Thr Lys Gly Asn Met Lys 240 245 250 tac aaa gca gtg agt gtc aac gaa ggc tat aaa gtc tgt gag aga ttg 820 Tyr Lys Ala Val Ser Val Asn Glu Gly Tyr Cys Glu Arg Leu 255 260 265 cca gca tac ttt gtt gtc ccc acc cct ctt cct gaa gag aat gtg cag 868 Pro Ala Tyr Phe Val Val Pro Thr Pro Leu Pro Glu Glu Asn Val Gln 270 275 275 280 cgc ttt cag ggt cat ggc ata cca ata tgg tgt tgg tcc tgc cac aat 916 Arg Phe Gln Gly His Gly Ile Pro Ile Trp Cys Trp Ser Cys His Asn 285 290 295 295 gga agt gcc ctt ttg aaa atg tca gca ctg ccc aaa gaa cag gat gac 964 Gly Ser Ala Leu Lys Met Ser Ala Leu Pro Lys Glu Gln Asp Asp 300 305 310 315 ggc att tta caa atc caa aag agc ttc tta gat gga att tac aag acc 1012 Gly Ile Leu Gln Ile Gln Lys Ser Phe Leu Asp Gly Ile Tyr Lys Thr 320 325 330 atc cac agg cca ccc tat gaa att gtt aaa acg gaa gac ctg tca agc 1060 Ile His Arg Pro Pro Tyr Glu Ile Val Lys Thr Glu Asp Leu Ser Ser 335 340 345 aac ttc ctg tcc ctg cag gaa atc cag act gca tct aaa ttt aaa 1108 Asn Phe Leu Ser Leu Gln Glu Ile Gln Thr Ala Tyr Ser Lys Phe Lys 350 355 360 cag cta ttt ctg ata gat aac agt act gaa ttt tgg gac aca gat ata 1156 Gln Leu Phe Leu Ile Asp Asn Ser Thr Glu Phe Trp Asp Thr Asp Ile 365 370 375 aaa aaa tgg ttt tct ctg ttg gaa agt agc agc tgg ctt gac ata atc aga 1204 Lys Trp Phe Ser Leu Leu Glu Ser Ser Ser Trp Leu Asp Ile Ile Arg 380 385 390 395 cg tg aaa aaa gca ata gag att aca gaa tgt atg gaa gca caa 1252 Arg Cys Leu Lys Lys Ala Ile Glu Ile Thr Glu Cys Met Glu Ala Gln 400 405 410 aac atg aat gtt ctt ctt tta gag gag aat gca tcc gac ctc tgc 1 Asn Met Asn Val Leu Leu Leu Glu Glu Asn Ala Ser Asp Leu Cys Cys 415 420 425 ctc att tcc tct ctg gtg caa ctg atg atg gac ccc cac tgc aga acc 1348 Leu Ile Ser Ser Leu Val Gln Leu Met Met Asp Pro His Cys Arg Thr 430 435 440 aga att ggt ttc cag agc ctc atc caa aag gag tgg gtc atg ggt ggc 1396 Arg Ile Gly Phe Gln Ser Leu Ile Gln Lys Glu Trp Val Met Gly Gly 445 450 455 cac tgt ttcg ttgatc aac cat ctc cgc cag aac gac aaa gag 1444 His Cys Phe Leu Asp Arg Cys Asn His Leu Arg Gln Asn Asp Lys Glu 460 465 470 470 475 gag gtt cct gtg ttc ctg ctt ttc cta gat tgt gtc tgg cag gtg gg Val Phe Leu Leu Phe Leu Asp Cys Val Trp Gln Leu Val 480 485 490 cac cag cat ccc ccg gca ttt gaa ttc aca gag act tac ctg act gtt 1540 His Gln His Pro Pro Ala Phe Glu Phe Thr Glu Thr Tyr Leu Thr Val 495 500 505 ttg tca gat agc ctg tat ata cct att ttt agc acc ttc ttc ttc aat 1588 Leu Ser Asp Ser Leu Tyr Ile Pro Ile Phe Ser Thr Phe Phe Phe Asn 510 515 520 tca cct cat caa aaa gat act aac atg ggt ga ggc cag gat aca 1636 Ser Pro His Gln Lys Asp Thr Asn Met Gly Arg Glu Gly Gln Asp Thr 525 530 535 caa agc aag cct ttg aat ctg ctc acc gtg tgg gat tgg tcg gtg cag 1684 Gln Ser Lys Pro Leu Asn Leu Leu Thr Val Trp Asp Trp Ser Val Gln 540 545 550 555 ttt gaa ccc aaa gcc cag aca ttg ctc aaa aac cct ctt tat gtg gaa 1732 Phe Glu Pro Lys Ala Gln Thr Leu Leu Lys Asn Pro Leu Tyr Val Glu 560 565 570 aag cca aaa ctg gac aaa ggc caa cgg aaa gga atg cgc ttc aaa cat 1780 Lys Pro Lys Leu Asp Lys Gly Gln Arg Lys Gly Met Arg Phe Lys His 575 580 585 585 caa cga caa ctt tct ttg cca ctt aca tcaca tcacaca tca aaa 1828 Gln Arg Gln Leu Ser Leu Pro Leu Thr Gln Ser Lys Ser Ser Pro Lys 590 595 600 aga gga ttt ttc agg gaa gaa aca gat cat tta att aaa aac ctt ctg 1876 Arg Gly Phe Phe Arg Glu Glu Thr Asp His Leu Ile Lys Asn Leu Leu 605 610 615 ggc aag aga att agc aaa ctt att aat tct tct gat gag ctc caa gac 1924 Gly Lys Arg Ile Ser Lys Leu Ile Asn Ser Ser Asp Glu Leu Gln Asp 620 625 630 635 aac ttt cgatat gac agc tgg cat agc aag tcc act gac tac 1972 Asn Phe Arg Glu Phe Tyr Asp Ser Trp His Ser Lys Ser Thr Asp Tyr 640 645 650 cat ggt ttg ttg tta ccg cat atc gag ggg ccc gaa atc aaa gtc tgg 2020 His G ly Leu Leu Leu Pro His Ile Glu Gly Pro Glu Ile Lys Val Trp 655 660 665 gcc cag cgc tac cta cgt tgg att cca gaa gcc caa atc cta ggt ggt 2068 Ala Gln Arg Tyr Leu Arg Trp Iyr Pro Glu Ala Gln Ile Leu Gly Gly 670 675 680 ggc caa gtg gcc act ctg agc aaa ctc ttg gaa atg atg gag gaa gtc 2116 Gly Gln Val Ala Thr Leu Ser Lys Leu Leu Glu Met Met Glu Glu Val 685 690 695 cag agt tta caa gag gag atg cac cac agc cag cag gcc 2164 Gln Ser Leu Gln Glu Lys Ile Asp Glu Arg His His Ser Gln Gln Ala 700 705 710 715 ccc cag gct gag gcc ccc tgc ctg ctg agg aac tct gcc cgc ctc tcg 2212 Pro Gln Ala Glu Alu Cys Leu Leu Arg Asn Ser Ala Arg Leu Ser 720 725 730 tct ttg ttt cct ttc gct ctg ctc cag cga cat tcc tct aag ccc gtc 2260 Ser Leu Phe Pro Phe Ala Leu Leu Gln Arg His Ser Ser Lys Pro Val 735 740 740 745 tta ccc acc agt ggc tgg aaa gct ttg gga gat gaa gac gat ttg gcc 2308 Leu Pro Thr Ser Gly Trp Lys Ala Leu Gly Asp Glu Asp Asp Leu Ala 750 755 755 760 aaa cga gaa gat gag ttc gtg gac cta ggg gatg gttt 2354 Lys Arg Glu Asp Glu Phe Val Asp Leu Gly Asp Val 765 770 775 gttgagtgat tgtgaaagag gaatgtggga gattgggaca gctgatccct ggatttgtgt 2414 cacgctacag ctcatgctgg ctgggtcctt agcccggcac tccgttagaa taaacctggg 2474 ccttcgggaa aagaggtggc tctcattatt tttcatgatt ctaaaagact atgcaattaa 2534 aaccgcatct gtagtattat taattggaag gaattattac ttgacccgta atagggttgt 2594 ggccgttttc tgatgcctaa gtattataca gagcccacaa tggccagttt actaccagaa 2654 agggcttcag taagatattc ttggacttga tactttcttc agatcctctt tgtgccaaga 2714 taatttatcc agtcattggg aatagtaagt ttctgtgtaa cccatctcaa ttatagaagc 2774 aagttcagct ttatgtattt gtatggggag ttgaagattc agatagaggt attaagatgt 2834 gtggcattta cttaaaccat cacatttttt tctttctacg cccccttgcc tgtaaaacac 2894 ctgggaagtt ccactggtgt catccatcct gatgcttcag accaccctcc cttcttcaca 2954 gaccgtgtca ctttgcctgt gggtgggggc tagccagcca ccaccctctt ttctgtgctg 3014 ccagccccag gtcttcctcc gcctgctcca caccactcgc cgctgtccct ctgcactccc 3074 tgccttggtg cgtgtagtcc cagtgtctca ctgccaaacc tcttggttac gctgcgggga 3134 tctgtt tctt tgcctgagat ccttcctgag gagcgtccat tcctctggag tctctccttg 3194 tttggaacaa atcgcttcgc ctttttctac ttgcctgctg aagctttgga gcacttgtga 3254 ttgcagtttt ctgccgcaac ccctgagccg agttcctcac attcttttac ctttatggac 3314 tgatgggatt gggtcacttt tgaatgtggc tttcatagga aagcagctta aacataaata 3374 tcagaagtga tgattatcat atgatacctc agtgatttta aaagccatag aagaaacttg 3434 actatgcctg gtcaccttct tggatctgct gtctaaatga tatatatatg atatatatat 3494 gatatatata tcatatatat gatatatatt ttttttaatg caggaaagta tactttgtaa 3554 ggagcagatt tttttgttct cagtggaacc ctgtcaaatc gcataaaaga ggaaaaaaac 3614 aaaactcatt agaatgtttt aaattgaatg ttcgcctttt acatatattt gctcttcagt 3674 atggatccca atttgaatgt tacatgttcg gaaaaacttt cagttgctca agggcaataa 3734 gaaaatttga ggccgggtgt ggtggctcac gcctgtaatc ccagcacttt gggaggctca 3794 ggtgggcgaa ttgcttgagc ccaggagttc gagaccagcc ggggcaacat ggcaaaaccc 3854 tgtctctact aaaaatacaa aaattagctg ggtgtggtgg tgcatgcctg tagtcccagc 3914 tactcgggag gctgaggtgg gaggatcccg tgagcctggg aggtggagtt tgcagtgagc 3974 taagatcgtg c cactgcact ccggcctggg tgatggagca agacctcgtc tcagaaaatt 4034 ggaaactatt gactaagaga agtttctagg tttgcactga attgtctttt gtacatacag 4094 tgaattgttt tgctgttctc cccactccat attaatgcag gagccaggtt ggtctgttag 4154 gatgaacaaa ggttgagggg agggcaggat tcgtgcatct gggggccaaa cacatgttcc 4214 gtcttgattg ccttaagagt tactagcgag gtcagtgtta ggcttgcaat agggatttta 4274 aaatacacta actagttcct tagctacctt cacatacatt ctataggcct tcttaaatta 4334 gcactaacct ccacttcctt ctctgcccca ttgcctccca aatatgctat ggagctattt 4394 ttgttaccac gttataacgt gaatatttat acagtagcct cttcaggctt tgtaattttc 4454 attccaaaaa tgcccggtgt gatgctttac actctacaaa gtatggttta aaggcacaag 4514 gtcatggcct ttgtcatagc agttgaatgt gcattgacat atttttctat gattttttaa 4574 aattacaata gaaaaataag ctgttgtaac gtgtaaggtc atgacaattt ttgtatttat 4634 atttgaaatc agatttctat aactcgtatt tgtgtacaga attctcaatg gatttatata 4694 ttgtgaaatt tttatctgag attgggatgt ggattatgct taacagtgag agctgaaatg 4754 agaccattta ctttgtttaa aatgctgtac tgtgcaagtt tggaaatgta aattaattta 4814 ctgtatataa tatctt gagt ttgtttatac ctccaagttt ttacactgaa gataaactag 4874 ctttaattca aaactttttt tttctttata agggaataag ctgttgagct aaacctgtat 4934 acttgtgctt tttattttct ggatgcacaa tgaaagttta tcagag atcagca tcatatca tgatc tcagca tcatccacagca <210> 80 <211> 5483 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2496) <400> 80 gca cag cca tct gtg gtg act agg agg tcc cca agc cga gga cac cca 48 Ala Gln Pro Ser Val Val Thr Arg Arg Ser Pro Ser Arg Gly His Pro 1 5 10 15 tca agg acc ttt aga gtg gcc tca gac caa ggt cac caa tca atg gct 96 Ser Arg Thr Phe Arg Val Ala Ser Asp Gln Gly His Gln Ser Met Ala 20 25 30 aac tgg ggg tcc caa aac cta gcc cag cca tct atg gac agt ggg gag 144 Asn Trp Gly Ser Gln Asn Leu Ala Gln Pro Ser Met Asp Ser Gly Glu 35 40 45 ccc tca agc cta gcc cag cca tct caa gcc cct ggg gta acc tca aat 192 Pro Ser Ser Leu Ala Gln Pro Ser Gln Ala Pro Gly Val Thr Ser Asn 50 55 60 ctg gcc cag cca tct caa gcc ttt ggg gtg tct cca agt cca gac tac 240 Leu Ala Gln Pro Ser Gln Ala Phe Gly Val Ser Pro Ser Pro Asp Tyr 65 70 75 80 cca tct cag tct gtt ggg gag tac cca atg ctg gct cag cca ttt cag 288 Pro Ser Gln Ser Val Gly Glu Tyr Pro Met Leu Ala Gln Pro Phe Gln 85 90 95 ccc act gag gtg tcc cca agt cca acc tac cca tct cag gcc att agg 336 Pro Thr Glu Val Ser Pro Ser Pro Thr Tyr Pro Ser Gln Ala Ile Arg 100 105 11 0 gag tac cca acc ctg gcc cag cca ttt cag ccc act gag gta tct cca 384 Glu Tyr Pro Thr Leu Ala Gln Pro Phe Gln Pro Thr Glu Val Ser Pro 115 120 125 agc cca gcc cac cca tat cag ctc act gag gtg tcc cca agt gca gcc 432 Ser Pro Ala His Pro Tyr Gln Leu Thr Glu Val Ser Pro Ser Ala Ala 130 135 140 tat tca tat cag ccc act gag gtg tcc cca aac cca ggc tac cta tct 480 Tyr Ser Tyr Gln Pro Thr Glu Val Ser Pro Asn Pro Gly Tyr Leu Ser 145 150 155 160 atg gcc att gag atg tcc cca agc cca gga tac cca tct gtg gcc act 528 Met Ala Ile Glu Met Ser Pro Ser Pro Gly Tyr Pro Ser Val Ala Thr 165 170 175 gag gtg tcc cca agc cca acc tac cca tat cag ccc act gag ata tcc 576 Glu Val Ser Pro Ser Pro Thr Tyr Pro Tyr Gln Pro Thr Glu Ile Ser 180 185 190 cca agc tca ggc tac cta tct gtg gcc act gag gtg tcc cca agc cca 624 Pro Ser Ser Gly Tyr Leu Ser Val Ala Thr Glu Val Ser Pro Ser Pro 195 200 205 ggc tac cca tct cag ctc act gag gtg tcc cca agc tca ggc tac cta 672 Gly Tyr Pro Ser Gln Leu Thr Glu Val Ser Pro Ser Ser Gly Tyr Le u 210 215 220 tct gtg gcc act gaa gtg tcc cca agc cca gac tac tca tct cag cct 720 Ser Val Ala Thr Glu Val Ser Pro Ser Pro Asp Tyr Ser Ser Gln Pro 225 230 235 240 act gag atg tcc cca agc tca ggc tac cta tct atg gcc act gag gtg 768 Thr Glu Met Ser Pro Ser Ser Gly Tyr Leu Ser Met Ala Thr Glu Val 245 250 255 tcc cca agc cca ggc tac cca ttt cag ccc act gag gtg tcc cca agc 816 Ser Pro Ser Pro Gly Tyr Pro Phe Gln Pro Thr Glu Val Ser Pro Ser 260 265 270 cca gac tat cca tgt gtg gcc act ggg gag tcc cct agc ctt gcc cag 864 Pro Asp Tyr Pro Cys Val Ala Thr Gly Glu Ser Pro Ser Leu Ala Gln 275 280 285 cca tct cag ccc act gag gtg tcc cca agc tca gcc tac cca tct gtg 912 Pro Ser Gln Pro Thr Glu Val Ser Pro Ser Ser Ala Tyr Pro Ser Val 290 295 300 gtc act ggg gag tct cca agc ctg gcc cag tca tat cag cgc act gag 960 Val Thr Gly Glu Ser Pro Ser Leu Ala Gln Ser Tyr Gln Arg Thr Glu 305 310 315 320 gtg ttc cca agc cca gcc tac cca ttt atg gcc act gag gtg tcc cca 1008 Val Phe Pro Ser Pro Ala Tyr Pro Phe Met AlaThr Glu Val Ser Pro 325 330 335 agc cca ggc gac cca tct gtg gtc act ggg gag tcc cca agc cca gcc 1056 Ser Pro Gly Asp Pro Ser Val Val Thr Gly Glu Ser Pro Ser Pro Ala 340 345 350 tac cca tct cag ccc act ggg gag tct cca agc ctg acc cag cca tct 1104 Tyr Pro Ser Gln Pro Thr Gly Glu Ser Pro Ser Leu Thr Gln Pro Ser 355 360 365 ctg acc atc aga gtg tcc cca tgc cta gcc atg tca tct cag act att 1152 Leu Thr Ile Arg Val Ser Pro Cys Leu Ala Met Ser Ser Gln Thr Ile 370 375 380 gga gtg tcc cca agc cta gcc atg cca tct cag acc att gga gtg tcc 1200 Gly Val Ser Pro Ser Leu Ala Met Pro Ser Gln Thr Ile Gly Val Ser 385 390 395 400 cca agc cta gcc atg cca ttt cat acc att gga gtg tcc cca acc cta 1248 Pro Ser Leu Ala Met Pro Phe His Thr Ile Gly Val Ser Pro Thr Leu 405 410 415 gct cac cca tct atg gcc att cgg gag tct cca agc ctg gcc cag cct 1296 Ala His Pro Ser Met Ala Ile Arg Glu Ser Pro Ser Leu Ala Gln Pro 420 425 430 cct cag tcc act ggg gaa tcc cca agc ttg acc tgg cca tct cag gcc 1344 Pro Gln Ser Thr Gly Glu S er Pro Ser Leu Thr Trp Pro Ser Gln Ala 435 440 445 act ggg gtg tcc cca agt gta gcc cac caa tct gtg gcc agt agg gtt 1392 Thr Gly Val Ser Pro Ser Val Ala His Gln Ser Val Ala Ser Arg Val 450 455 460 tcc tca agc cta gcc cag cca tct caa gcc agt ggg atg tcc cct aga 1440 Ser Ser Ser Leu Ala Gln Pro Ser Gln Ala Ser Gly Met Ser Pro Arg 465 470 475 475 480 caa gat tac cca cca gtg gcc tcc agg gtg tcc cca aac caa gct cac 1488 Gln Asp Tyr Pro Pro Val Ala Ser Arg Val Ser Pro Asn Gln Ala His 485 490 495 gca tct ata acc agc agg atg tcc cct agc aga gct cat gca tct atg 1536 Ala Ser Ile Thr Ser Arg Met Ser Pro Ser Arg Ala His Ala Ser Met 500 505 510 acc tgt atg gtg tcc cca agc cag gtt cat cga tct atg ccc agt gag 1584 Thr Cys Met Val Ser Pro Ser Gln Val His Arg Ser Met Pro Ser Glu 515 520 525 gtg tcc cca agc ctt gcc cag cta tct caa gcc acc act gca gtg ccc 1632 Val Ser Pro Ser Leu Ala Gln Leu Ser Gln Ala Thr Thr Ala Val Pro 530 535 540 tta aga cca gct cat caa cct atg gcc tgt ggt gta tcc cca agc cta 1680 Leu A rg Pro Ala His Gln Pro Met Ala Cys Gly Val Ser Pro Ser Leu 545 550 555 560 gcc cag ccg tct caa gcc aca ggg atg tct tca agg cta gcc cac caa 1728 Ala Gln Pro Ser Gln Ala Thr Gly Met Ser Ser Arg Leu Ala His Gln 565 570 575 cct atg acc tgt gtg gtg tcc tta agc cca gcc cag cca tct caa gcc 1776 Pro Met Thr Cys Val Val Ser Leu Ser Pro Ala Gln Pro Ser Gln Ala 580 585 590 att ggt gtg tcc cca agc cta gcc cac cca tca gga ccc cat ggg ttg 1824 Ile Gly Val Ser Pro Ser Leu Ala His Pro Ser Gly Pro His Gly Leu 595 600 605 tct cca agt cta gct cac cca tat gtg gcc agt ggg gcg ggc tcc agc 1872 Ser Pro Ser Leu Ala His Pro Tyr Val Ala Ser Gly Ala Gly Ser Ser 610 615 620 cta gcc tac cca tct cag acc act gca gta tcc cca agg caa gcc caa 1920 Leu Ala Tyr Pro Ser Gln Thr Thr Ala Val Ser Pro Arg Gln Ala Gln 625 630 635 640 cca tct gtg gcc tcc agc cca ggc aag aca tat tca tcc tgt acc cta 1968 Pro Ser Val Ala Ser Ser Pro Gly Lys Thr Tyr Ser Ser Cys Thr Leu 645 650 655 gcc tcc agc cta gcc gag cca gct ata gcc ccc agc cta ttc cca cca 2016 Ala Ser Ser Leu Ala Glu Pro Ala Ile Ala Pro Ser Leu Phe Pro Pro 660 665 670 tct gtg gcc cac acg gaa gcc cta agc ctg gct cag tca ccc ccg gac 2064 Ser Val Ala His Thr Glu Ala Leu Ser Leu Ala Gln Ser Pro Pro Asp 675 680 685 act agg ttg gcc cca agc cga tcc cag cca tct gtg gtc agt ggt aca 2112 Thr Arg Leu Ala Pro Ser Arg Ser Gln Pro Ser Val Val Ser Gly Thr 690 695 700 tgt cat ggc ctc aat gag cca tgc tgg ggc tct agg ctg gat tca aat 2160 Cys His Gly Leu Asn Glu Pro Cys Trp Gly Ser Arg Leu Asp Ser Asn 705 710 715 715 720 ctg cag tgt tca agg gtg gac tca gta gcc ccg tgt ctg tgt cacca Gln Cys Ser Arg Val Asp Ser Val Ala Pro Cys Leu Cys His Pro 725 730 735 tca gcg ttt gtt tca gtt agc ctg ggt gga cca tat ccc tct gtg gct 2256 Ser Ala Phe Val Ser Val Ser Leu Gly Gly Pro Tyr Pro Ser Val Ala 740 745 750 gga aat atg gac cag ggt ctg aac cag cca tcc ctg ggt act ggg gtg 2304 Gly Asn Met Asp Gln Gly Leu Asn Gln Pro Ser Leu Gly Thr Gly Val 755 760 765 aac cta tgt gaa gaa cct ctg atg gtt agt gag atg gta tcc agc ccc 2352 Asn Leu Cys Glu Glu Pro Leu Met Val Ser Glu Met Val Ser Ser Pro 770 775 780 ccg gac ttc aag ttc aac gac gtg tcc ctt ggg ttc cat cat cca ccc 2400 Pro Asp Phe Lys Phe Asn Asp Val Ser Leu Gly Phe His His Pro Pro 785 790 795 800 agg gtt ggt ggg agg cat gtg tgt cca ccc tct gtg gtt agt gtt tca 2448 Arg Val Gly Gly Arg His Val Cys Pro Pro Ser Val Val Ser Val Ser 805 810 815 aca cca aat ctc tct cat gct gat gag gag gcc tgt tgt gta ggc cag 2496 Thr Pro Asn Leu Ser His Ala Asp Glu Glu Ala Cys Cys Val Gly Gln 820 825 830 tgaatcacgc ctctgttcag gggtgtgcc gcaggtgccctg 2616 tggagaacca tagcaactgg catgggccaa agtcaatgtc aggtggccaa tggcatggct 2676 tcccttgcat cccaggtctt agaggcaggt ggccctttga cacatccctc tggaaccaca 2736 gggatggccc ccagcccctc tctggcttca gtgcccaaca gactggccgt gactcagtct 2796 aatctttccc tgaacagcat gggccccagc agctcccaga tcagtgtggt tattccaaaa 2856 aacatagact gctggcacc c ttctgaggca tccatggtcc cacccagtta ccagcagaga 2916 gatgtgattc cgcaggactc tctgaagagc agggctggtc gtggtgcggc aggaggtttt 2976 gtagccagta gaatgagcac gggcgcagtc ccaggcactc tgcctggtgg cataacctcc 3036 agccttcccc cgggctccac catccgaggc atgggtcaca gccttcccgc aggctctgtg 3096 tccagttggg tggctcccag tctgatggca gacagaaaga agccaagtct atctgtaaga 3156 ccctccgcta gcttagctgc tccaaacttg ctcccaggtt cagtagtgag tcgggtgagc 3216 ccagttgtcc cccctggttc tgtgccaatg atgggggcct ctagtgtggc tcagagctgc 3276 tccaaggggc ccatggtgat tgacatcact gcccctcctt acctcaaagc cctggctggg 3336 gagaggtctt tagccccctt gcagatgccc cacaccacca gtctggctcc aggtcactcc 3396 tcagccccgg cagctagtgg cacagtgagg agtctacacc gagtgcccac ggttctatca 3456 agagccttac aattgagcca agatgctagg ataatgccat ctggggtcac aggggaccaa 3516 gccaagctag gagaattgga tgaggctgtg ttccaagtgt caggatcaag tggatccaat 3576 gacctattca gcaaagccag ggtcactggt gcaacccagt ggatgtactc cagtcctctg 3636 ggagctgatg ggggccatga tcataggtcc ctgtctgaga aagggtctct tccccaaggg 3696 aggtggctcc cagccatgct agtg gcatgg tccctgtccc tttccaggcc ccgggtttag 3756 ccactaagtc cccctcagtt tatcaacagg ggtctgtcgt tcacgtcata ccccaaaatc 3816 actctcaggg tacagtggct tctaatgtag tctcaggatc accccagctg gcccgtggca 3876 gtactgaggc tttcagattg ctttcagtgt ctgtgggcag gatggggaat cctagtcttc 3936 ttcagaggtc agggaccacc agcatggtct cacatgtgcc actatatccg tcctcggcta 3996 gaagggcatt gtccagtccc ttccagacag aagctgtccc caatccactc cagaaaacag 4056 tgtctggaaa catggctccg agcagccgct gggacgccat gggccctaaa aattcctaca 4116 gatccatgca tggtaggatt gttccagaac tgctagaaag ttctgtggcc agggttaggc 4176 ccttccagta tgtgcaaaga caaccatccc aggcctcagc ccgaagtggt gcaaacccca 4236 cccacaggcc ctctgcagag gtaaggcccg tcatctgcac tggggagatg acacactcct 4296 cggtcattcc tccgctggcc ccgggagttc ggagggtgtc tctaggctat gagtcttccc 4356 caagtggttc cctgccaccc ctttttaacc aggagtcacc gtggagatgg caggactcct 4416 atagcctcca gaatcctgcc gttagtcaca aggcatccct gaactccact atactccagg 4476 gccccgcgga cgctggtgtg gttggtggcc aatcgtggaa ccgcgcatgg gagccagcca 4536 ggggtgctgc gtcctgggac acctggcgc a acaaggcggt ggtgcatccc aggcggtccg 4596 gggagccaat ggtgtccatg caggctgcag aggagatccg catcctcgca gtgatcacta 4656 tccaggcggg cgtccgtggc tacctggcgc gtcgcaggat ccggctgtgg caccgggggg 4716 ccatggtcat ccaagctact tggcgcggct accgtgtgcg gcggaacctg gcacacctct 4776 gcagagccac cacgaccatc cagtctgcct ggcgcggcta cagcacccgc cgggaccaag 4836 cccggcactg gcagatgctc caccccgtca cgtgggtgga gctgggcagc cgggccgggg 4896 tcatgtctga ccgaagctgg ttccaggatg gcagagccag gacagtatct gaccatcgct 4956 gcttccagtc ctgccaggca cacgcttgca gcgtctgcca ctccctgagc tccaggatcg 5016 ggagcccgcc cagcgtggtg atgctagtgg gctccagccc tcgcacctgt catacctgtg 5076 gacgcacaca gcccacccgt gtggtgcagg gcatgggcca gggcactgag ggccccgggg 5136 cagtgtcttg ggcctccgcc taccagctgg ctgccctgag tcccaggcag ccgcatcgcc 5196 aggacaaagc ggccacagcc atccagtccg cctggagggg ctttaagatc cgccagcaga 5256 tgaggcagca gcaaatggca gcgaagatag ttcaagccac ctggcgaggc caccataccc 5316 ggagctgtct gaagaacaca gaggcgctct tgggaccagc agacccctcg gccagctcac 5376 ggcacatgca ttggcctggc atctaggacc ctgg ctccct gcagtgggga cttcgtggga 5436 ggcactcatg gctctctggg tctaatgaat aaagtcctcc acagcct 5483 <210> 81 <211> 3996 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2286) <400> 81 ggc gcc ggc ggc ctc tac aag cgc ggc tcg gtg cgc tcg ctc agc acc 48 Gly Ala Gly Gly Leu Tyr Lys Arg Gly Ser Val Arg Ser Leu Ser Thr 1 5 10 15 tac tcg gcc gcc gcg ctg cag ctg gag gac tcc ctg tac aag 96 Tyr Ser Ala Ala Ala Leu Gln Ser Asp Leu Glu Asp Ser Leu Tyr Lys 20 25 30 gcg gcg ggc ggc ggc ggc ccg ctg tac ggc gac ggc tac ggc ttc cgc Gly Ala Gla Pro Leu Tyr Gly Asp Gly Tyr Gly Phe Arg 35 40 45 ctg ccg cct tcg tca ccg cag aag ctg gcc gac gtg gca gca ccc ccc 192 Leu Pro Pro Ser Ser Pro Gln Lys Leu Ala Asp Val Ala Ala Pro Pro 50 55 60 gga ggt ccc ccg cca ccg cac agc ccc tac tcg ggg ccg ccc agc cgc 240 Gly Gly Pro Pro Pro Pro His Ser Pro Tyr Ser Gly Pro Pro Ser Arg 65 70 75 80 ggc tcg cca gtg cgc cag tcc ttc cgc aag gac tcg ggc tcg tcc 288 Gly Ser Pro Val Arg Gln Ser Phe Arg Lys Asp Ser Gly Ser Ser Ser 85 90 95 gtc ttt gcc gag agt cct gga ggg aag acc cgc agc gcg ggg agc gcc 336 Val Phe Ala Glu Ser Pro Gly Gly Lys Thr Arg Ser Ala Gly Ser Ala 100 105 11 0 tcg acg gcc gga gct ccc cct tcg gag ctc ttc cct ggg cct ggg gaa 384 Ser Thr Ala Gly Ala Pro Pro Ser Glu Leu Phe Pro Gly Pro Gly Glu 115 120 125 cgc tcg ctg gtt ggg ttc ggg ccg cca gtg cca gcc gac acg gag 432 Arg Ser Leu Val Gly Phe Gly Pro Pro Val Pro Ala Lys Asp Thr Glu 130 135 140 acc agg gag cgc atg gag gcc atg gag aag cag att gcc agc ctc aca 480 Thr Arg Glu Arg Met Glu Ala Met Glu Lys Gln Ile Ala Ser Leu Thr 145 150 155 160 ggc ctg gtg cag agc gcc tta ctg cga ggc tct gag cct gag acc ccc 528 Gly Leu Val Gln Ser Ala Leu Leu Arg Gly Ser Glu Pro Glu Thr Pro 165 170 175 agc gag aag att gaa ggc tcc aat gga gca gcc acc ccc tca gca ccc 576 Ser Glu Lys Ile Glu Gly Ser Asn Gly Ala Ala Thr Pro Ser Ala Pro 180 185 190 tgt ggg tca ggc ggc cgg agc agc ggg gcc acc ccg gtg tcc Cyccc ccg 624 Gly Ser Gly Gly Arg Ser Ser Gly Ala Thr Pro Val Ser Gly Pro 195 200 205 ccc ccg ccc tcg gcc agc agc acc ccc gca ggt cag cct acc gcc gtt 672 Pro Pro Pro Ser Ala Ser Ser Thr Pro Ala Gly Gln Pro Thr Ala V al 210 215 220 agc cgg ctg cag atg cag ctt cac ctg cga ggc ctg cag aac agc gcc 720 Ser Arg Leu Gln Met Gln Leu His Leu Arg Gly Leu Gln Asn Ser Ala 225 230 235 240 agt gac ttg cgc ggc cag ctc ttg cgc aag ctc cag cta cag 768 Ser Asp Leu Arg Gly Gln Leu Gln Gln Leu Arg Lys Leu Gln Leu Gln 245 250 255 aac cag gag tcg gtg cgc gcg ctg ctg aag cgc acg gag gca gag Gg Gn Gg Gn Gn Gn Gn Gn Gn Gn Gn Gn Asn Ala Leu Leu Lys Arg Thr Glu Ala Glu Leu 260 265 270 agc atg cgc gtg tcg gag gcg gcg cgg cgg cag gag gac ccg ctg cag 864 Ser Met Arg Val Ser Glu Ala Ala Arg Arg Gln Glu Asp Pro Leu Gln 275 280 cag cgc acc ctg gtg gaa gag gaa cgg ctg cgc tat ctc aac gac 912 Arg Gln Arg Thr Leu Val Glu Glu Glu Arg Leu Arg Tyr Leu Asn Asp 290 295 300 gag gag ctt att acc cag cag ctc aat gac tg gag 960 Glu Glu Leu Ile Thr Gln Gln Leu Asn Asp Leu Glu Lys Ser Val Glu 305 310 315 320 aag atc cag aga gac gtg tcc cac aac cac cgg ctg gtg ccc ggc cct 1008 Lys Ile Gln Arg Asp Val Ser His Asn His ArgLeu Val Pro Gly Pro 325 330 335 gag ctg gag gag aag gca ctg gtg ctg aag cag ctc ggg gag acg ctg 1056 Glu Leu Glu Glu Lys Ala Leu Val Leu Lys Gln Leu Gly Glu Thr Leu 340 345 350 350 aca gag cc cag gag ttc ccg ggc ctg cag agc aag atg cgg gtg 1104 Thr Glu Leu Lys Ala His Phe Pro Gly Leu Gln Ser Lys Met Arg Val 355 360 365 gtg ctg cgc gtg gag gtg gag gcg gtg aag ttc ctg acc gag gag gag gag gag Val Glu Val Glu Ala Val Lys Phe Leu Lys Glu Glu Pro 370 375 380 cag cgc ctg gat ggg ctc ctc aag cgc tgc cgc ggg gtc acg gac acg 1200 Gln Arg Leu Asp Gly Leu Leu Lys Arg Cys Arg Gly Val Thrp 390 395 400 ctg gcc cag atc cga agg caa gtg gat gag ggt gtg tgg cca ccc ccc 1248 Leu Ala Gln Ile Arg Arg Gln Val Asp Glu Gly Val Trp Pro Pro Pro 405 410 415 aac aat ctc ctg agt cag tcc ccc aag aag gt acg gca gag act gac 1296 Asn Asn Leu Leu Ser Gln Ser Pro Lys Lys Val Thr Ala Glu Thr Asp 420 425 430 ttc aac aag agc gtg gac ttc gaa atg cca ccc ccc agc ccc ccg ctg 1344 Phe Asn Lys Ser Val Asp Phe Glu Met Pro Pro Pro Ser Pro Pro Leu 435 440 445 aac ctg cat gag ctg agc ggg cca gct gaa gga gcc tct ctt acc ccc 1392 Asn Leu His Glu Leu Ser Gly Pro Ala Glu Gly Ala Ser Leu Thr Pro 450 455 460 aag ggg ggc aac ccc acc aaa ggc ctg gac act cct ggc aag aga agc 1440 Lys Gly Gly Asn Pro Thr Lys Gly Leu Asp Thr Pro Gly Lys Arg Ser 465 470 470 475 480 gtg gac aaa gct gtg tct gtt gag gct gca gag cga gag gag 1488 Val Asp Lys Ala Val Ser Val Glu Ala Ala Glu Arg Asp Trp Glu Glu 485 490 495 aag cgg gca gcc ctg acc cag tac agt gcc aag gac atc aac cgg ctg 1536 Lys Arg Ala Ala Leu Thr Gln Tyr Ser Ala Lys Asp Ile Asn Arg Leu 500 505 510 ctg gaa gag aca cag gca gag ctg ctc aag gcc atc cct gac ctg gac 1584 Leu Glu Glu Thr Gln Ala Glu Leu Leu Lys Ala Ile Pro Asp Leu Asp 515 520 525 tgt gcc ag ag cca ggc ccg gcc ccc act cca gat cac aag 1632 Cys Ala Ser Lys Ala His Pro Gly Pro Ala Pro Thr Pro Asp His Lys 530 535 540 ccc ccc aag gcc ccc cac ggc cag aag gca gcc ccc cga acg gag ccc 1680 Pro P ro Lys Ala Pro His Gly Gln Lys Ala Ala Pro Arg Thr Glu Pro 545 550 555 560 agt ggg agg agg ggc tca gat gag ttg acc gtg ccc cga tac cgc aca 1728 Ser Gly Arg Arg Gly Ser Asp Glu Leu Thr Val Pro Arg Tyr Arg Thr 565 570 575 gag aag ccc tcc aag tcg ccc cca ccg ccc cct ccc cgc cgg agc ttc 1776 Glu Lys Pro Ser Lys Ser Pro Pro Pro Pro Pro Pro Arg Arg Ser Phe 580 585 590 ccc tcc tcc cat ggc ctg acc acc aca cgt acc gga gag gtg gtg gtc 1824 Pro Ser Ser His Gly Leu Thr Thr Thr Arg Thr Gly Glu Val Val Val 595 600 605 acc agc aag aag gac tcg gcc ttc atc aag aag gct gag tcc gag gag 1872 Thr Ser Lys Lys Asp Ser Ala Phe Ile Lys Lys Ala Glu Ser Glu Glu 610 615 620 ctg gag gtg cag aag ccc cag gtg aag ctg cgc cgg gct gtg tct gag 1920 Leu Glu Val Gln Lys Pro Gln Val Lys Leu Arg Arg Ala Val Ser Glu 630 630 630 gtg gcc cgc cca gcc tcc aca cca ccc atc atg gcc tcg gcc atc aag 1968 Val Ala Arg Pro Ala Ser Thr Pro Pro Ile Met Ala Ser Ala Ile Lys 645 650 655 gac gag gat gac gag gat cgc atc atc gca gag cta ga g agt ggc gga 2016 Asp Glu Asp Asp Glu Asp Arg Ile Ile Ala Glu Leu Glu Ser Gly Gly 660 665 670 ggc agt gta cca ccc atg aag gtg gtg act ccg ggg gcc tct cgg ctg 2064 Gly Ser Val Pro Pro Met Lys Val Thr Pro Gly Ala Ser Arg Leu 675 680 685 aag gcg gcc cag ggc cag gcg ggc agc ccc gac aaa agc aaa cat ggc 2112 Lys Ala Ala Ala Gln Gly Gln Ala Gly Ser Pro Asp Lys Ser Lys His Gly 690 695 700 aag cag agg gag tac atg cgg atc cag gcc cag cag cag gcc act 2160 Lys Gln Arg Ala Glu Tyr Met Arg Ile Gln Ala Gln Gln Gln Ala Thr 705 710 715 720 aaa cca tct aaa gag atg agc ggg tcg aat gag acc tcg agc cca gtc Lys Pro Ser Lys Glu Met Ser Gly Ser Asn Glu Thr Ser Ser Pro Val 725 730 735 tca gaa aag ccc tcg gct tcc aga acc tct atc cct gta ttg act tcc 2256 Ser Glu Lys Pro Ser Ala Ser Arg Thr Ser Ile Pro Val Leu Thr Ser 740 745 750 ttt ggg gca agg aat tct tcc atc tcc ttc tagaagcccc tcaccccgct 2306 Phe Gly Ala Arg Asn Ser Ser Ile Ser Phe 755 760 gccccgcctg tccccctccc tcactcctgc catttctccc ctctcttcctcat ccac 2366 cccaccccac cctactctcc agacgccctg aggggtgtgc cctgaagagg agggtgcggc 2426 cctcctcagc gacccctacc catcatctgt tggtgttttt ggttttgttt tttttttttt 2486 tttaacaatt aacttttaat tatctttttt taaacagtaa aactaaaaac caaacacacc 2546 accttccttg atcccagctg gcctctcgct ggccgcacct gtcacatctc tccttcttct 2606 ctttcaccac tctttccccc agtccatcct gaagctcctg cacccccttc ccgccttccc 2666 ctcacttccc aagaatactc caaacaaact ctgaaccacg gagacttgga gcagtgggag 2726 acccctctcc cgtttctcga taccttcctg gaggaacgcg gggacatcgg accaacccat 2786 acatcaagcc agagagcggg gcttagggag actggccttg gagatgcccc actccctgtc 2846 taagctccga caagactgtg acttcctctg tggctgctct gcctcctccc actcacaccc 2906 aagtgggcct ggagtagaga cggacaggct ggagacgagg ccggagtttg agaggcctca 2966 gggtgggtgt gaggccatgg agtctgtatc cctggggagg cgctggcctc ctgggccttg 3026 ccgtccagtg gggagtggag ggcagaggcc ctttggtctg ctggctgtgg agggtgggtt 3086 gcacggacag ccggatatcg gggacactgc cttgggagag ggcggcccgg acgggtattt 3146 ggtactttta gtttcctgat ttagcacttt aaatggcatt aacttattga atggggatgg 3206 ggtgggcaag agtgaggggc ctagaaaacc aggttttgtg gcttgcagtt gggggaaggg 3266 tctggtttga gggaaatggg agggtcgaga ggggcttgac ggggagcact gaagacacct 3326 gggacccgca ggtggggtga cttgaacttc agtcatcctc ttggcaattt gagggttttc 3386 ccaggaaagg atgagacgta gtttttcaat ggggctctgg tgaccctggt gagatgtctg 3446 aaggtccctg aggcctgacc atccagccag cgcccctggc ctgtggacgc cctgcctgcc 3506 ctgcagaggc ggttggcagt gccgcctggc ttttggccgg gtcctgggga ggcagagaga 3566 ggccaatttt ggttctcact cctggccccc cagagggcac agtgaggagc cggtagggag 3626 aggataggag aagaggagga ggaggagcgg ggtccccggc cgcaggattc ccacttggag 3686 cacaaagtga agtaagcaca ggggaggggg actagaatca gtcccccata gcaagcacag 3746 aaaggaggag ctgcgcagaa ggcagagccc cccagaccct ggggcctggc tggggaaggt 3806 ccgcacctgg ggagagctgg gagctgttga aggtttgggg ggaggggaaa cgggttgtgt 3866 ttcttcattt ctttttttgt ttttgccttt gttggttcat ccttgttttc tagctttgga 3926 tcatttttgt accaaggcga gcaagccttt ttgaaaaata acaaaagagg aaaaaaaaaa 3986 tccctcctgg 3996 <210> 82 <211> 5874 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3233) <400> 82 aa gag att gag aag gag aaa aaa gtg gag cca tgg aaa gaa caa ttc 47 Glu Ile Glu Lys Glu Lys Lys Val Glu Pro Trp Lys Glu Gln Phe 1 5 10 15 ttt gaa agc tac tat ggg cag agt tct ggc ctg agc ctt gaa gat tct 95 Phe Glu Ser Tyr Tyr Gly Gln Ser Ser Gly Leu Ser Leu Glu Asp Ser 20 25 30 aag aaa ttg aca gct tct ccc agt gat ccc aaa gta aag aaa acc cca 143 Lys Lys Leu Thr Ala Ser Pro Ser Asp Pro Lys Val Lys Lys Thr Pro 35 40 45 gct gaa caa cca aaa tcc atg cct gtg tca gag gcc tct ctt atc aga 191 Ala Glu Gln Pro Lys Ser Met Pro Val Ser Glu Ala Ser Leu Ile Arg 50 55 60 ata gtt cca gta gtc tcc cag tca gag tgt aaa gaa gaa gca ttg caa 239 Ile Val Pro Val Val Ser Gln Ser Glu Cys Lys Glu Glu Ala Leu Gln 65 70 75 atg tca tca cca ggc aga aaa gaa gag tgt gaa agc caaggta 287 Met Ser Ser Pro Gly Arg Lys Glu Glu Cys Glu Ser Gln Gly Glu Val 80 85 90 95 cag ccg aac ttc tcc aca tct tca gag ccc ctg ctt tcc tca gct ctc 335 Gln Pro Asn Phe Ser Thr Ser Ser Glu Pro Leu Leu Ser Ser Ala Leu 100 105 110 aat aca cat gag ctt agc agc att ctt ccc atc aag tgc cca aag gat 383 Asn Thr His Glu Leu Ser Ser Ile Leu Pro Ile Lys Cys Pro Lys Asp 115 120 125 gag gat ctc ttg gag cag aag cca gtc acc tct gct gaa cag gaa tct 431 Glu Asp Leu Leu Glu Gln Lys Pro Val Thr Ser Ala Glu Gln Glu Ser 130 135 140 gag aag aac cat ctc acc aca gct tct aat tat aac aaa agt gaa agc 479 Glu Lys Asn His Leu Thr Thr Ala Ser Asn Tyr Asn Lys Ser Glu Ser 145 150 155 caa gaa tct tta gtt aca tcg cca agc aaa ccc aag agt cct ggg gtt 527 Gln Glu Ser Leu Val Thr Ser Pro Ser Lys Pro Lys Ser Pro Gly Val 160 165 170 175 gaa aaa cca ata gtg aag ccc aca gca gga gcg ggt cca cag gag act 575 Glu Lys Pro Ile Val Lys Pro Thr Ala Gly Ala Gly Pro Gln Glu Thr 180 185 190 aat atg aaa gaa cct cta gca act ctt gtt gat cag agc cca gaa agc 623 Asn Met Lys Glu Pro Leu Ala Thr Leu Val Asp Gln Ser Pro Glu Ser 195 200 205 ctc aag agg aag tct tcc ctc acc caa gaa gag gcc cct gtg agc tgg 671 Leu Lys Arg Lys Ser Ser Leu Thr Gln Glu Glu Ala Pro Val Ser Trp 210 215 220 gag aag agg cca cgt gtc act gag aat cgc cag cac cag cag cca ttt 719 Glu Lys Arg Pro Arg Val Thr Glu Asn Arg Gln His Gln Gln Pro Phe 225 230 235 cag gtc tca cca cag ccc ttt ctc aat aga ggg gac aga atc cag gtg 767 Gln Val Ser Pro Gln Pro Phe Leu Asn Arg Gly Asp Arg Ile Gln Val 240 245 250 255 cga aaa gta cca cct ctc aag atc ccg gtc tcc aga atc tcc ccc atg 815 Arg Lys Val Pro Pro Leu Lys Ile Pro Val Ser Arg Ile Ser Pro Met 260 265 270 ccg ttt cat cca tcg cag gtc tct ccc agg gct cgt ttt cca gtc tcc 863 Pro Phe His Pro Ser Gln Val Ser Pro Arg Ala Arg Phe Pro Val Ser 275 280 285 atc act agt cct aac aga aca gga gcc aga act ctt gca gac atc aaa 911 Ile Thr Ser Pro Asn Arg Thr Gly Ala Arg Thr Leu Ala Asp Ile Lys 290 295 300 gca aaa gcc caa ctg gtc aaa gca cag agg gca gca gct gcc gct gcc 959 Ala Lys Ala Gln Leu Val Lys Ala Gln Arg Ala Ala Ala Ala Ala Ala 305 310 315 gcc gca gct gct gca gcc gcc tca gtt gga ggg acc att cca gga cct 1007 Ala Ala Ala Ala Ala Ala Ala Ser Val Gly Gly Thr Ile Pr o Gly Pro 320 325 330 335 ggc cca ggg ggt gga caa ggt cca gga gag ggt ggt gaa ggg cag act 1055 Gly Pro Gly Gly Gly Gln Gly Pro Gly Glu Gly Gly Gly Glu Gly Gln Thr 340 345 350 gct aga gga ggc agt cca ggc tca gac aga gtc agt gaa act gga aag 1103 Ala Arg Gly Gly Ser Pro Gly Ser Asp Arg Val Ser Glu Thr Gly Lys 355 360 365 ggc ccc aca ctg gaa ctg gca gga act gga agc agg gga ggt acg aga 1151 Gly Pro Thr Leu Glu Leu Ala Gly Thr Gly Ser Arg Gly Gly Thr Arg 370 375 380 gag ctt tta ccc tgt ggt cca gag act cag ccc cag tct gag acc aag 1199 Glu Leu Leu Pro Cys Gly Pro Glu Thr Gln Pro Gln Ser Glu Thr Lys 385 390 395 acc acc cca agc cag gca cag cct cat agt gtc tct gga gca caa cta 1247 Thr Thr Pro Ser Gln Ala Gln Pro His Ser Val Ser Gly Ala Gln Leu 400 405 410 415 cag caa acc ccc cca gtg cct cca aca cct gcc gtc agt gga gca tgc 1295 Gln Gln Thr Pro Pro Val Pro Pro Thr Pro Ala Val Ser Gly Ala Cys 420 425 430 aca agt gtc cca tca cca gcc cac ata gag aaa ttg gat aat gaa aaa 1343 Thr Ser Val Pro Ser Pro Ala Hi s Ile Glu Lys Leu Asp Asn Glu Lys 435 440 445 ctg aac ccc acc aga gca aca gcc aca gtg gcc tct gtc agc cat cca 1391 Leu Asn Pro Thr Arg Ala Thr Ala Thr Val Ala Ser Val Ser His Pro 450 455 460 caa ggg ccc agt agt tgc aga cag gag aaa gca cct tct cca aca ggt 1439 Gln Gly Pro Ser Ser Cys Arg Gln Glu Lys Ala Pro Ser Pro Thr Gly 465 470 475 cct gct cta atc tca ggt gcc tca cct gtt cat tgt gca gct gat ggc 1487 Pro Ala Leu Ile Ser Gly Ala Ser Pro Val His Cys Ala Ala Asp Gly 480 485 490 495 aca gtt gag ctc aaa gca ggt cct agt aag aat ata cct aac cct tca 1535 Thr Val Glu Leu Lys Ala Gly Pro Ser Lys Asn Ile Pro Asn Pro Ser 500 505 510 gcc tca tca aag aca gat gct agt gtg cca gtg gct gta act ccc tcc 1583 Ala Ser Ser Lys Thr Asp Ala Ser Val Pro Val Ala Val Thr Pro Ser 515 520 525 cct tta aca tct tta ttg acc aca gcc act tta gaa aag ctt cct gta 1631 Pro Leu Thr Ser Leu Leu Thr Thr Ala Thr Leu Glu Lys Leu Pro Val 530 535 540 ccc cag gtc agt gca act aca gca cct gct gga tca gct cca ccc tcg 1679 Pro Gln Va l Ser Ala Thr Thr Ala Pro Ala Gly Ser Ala Pro Pro Ser 545 550 555 agc act ttg cca gca gct tct agc ctt aaa acc cca gga act tct tta 1727 Ser Thr Leu Pro Ala Ala Ser Ser Leu Lys Thr Pro Gly Thr Ser Leu 560 565 570 575 aac atg aat gga ccc act tta aga cca acc tct agt atc cct gct aat 1775 Asn Met Asn Gly Pro Thr Leu Arg Pro Thr Ser Ser Ile Pro Ala Asn 580 585 590 590 aat cct tta gtg act cag ctg ctt caa ggc aaa gat gtt ccc atg gag 1823 Asn Pro Leu Val Thr Gln Leu Leu Gln Gly Lys Asp Val Pro Met Glu 595 600 605 caa att ctg cct aaa cct ctc acc aaa gtt gaa atg aaa acg gtt cca 1871 Gln Ile Leu Pro Lys Pro Leu Thr Lys Val Glu Met Lys Thr Val Pro 610 615 620 ctg act gca aaa gag gaa agg ggg atg gga gcg ctc ata gct acc aac 1919 Leu Thr Ala Lys Glu Glu Arg Gly Met Gly Ala Leu Ile Ala Thr Asn 625 630 630 635 aca aca gaa aat agc acc aga gag gaa gtt aat gag aga cag tcc cat 1967 Thr Thr Glu Asn Ser Thr Arg Glu Glu Val Asn Glu Arg Gln Ser His 640 645 650 655 cca gct acg cag cag cag ctg ggc aaa acc ttg caa agt aag cag ctc 2015 Pro Ala Thr Gln Gln Gln Leu Gly Lys Thr Leu Gln Ser Lys Gln Leu 660 665 670 ccc cag gtt cca agg ccc ctt cag ctc ttt tca gct aag gag ctg agg 2063 Pro Gln Val Pro Arg Pro Leu Gln Leu Phe Ser Ala Lys Glu Leu Arg 675 680 685 gac tcc agc att gac aca cac caa tac cac gaa gga cta agt aaa gca 2111 Asp Ser Ser Ile Asp Thrr His Gln Tyr His Glu Gly Leu Ser Lys Ala 690 695 700 acc caa gat cag atc ctt cag act ctc att cag agg gtt cgg agg cag 2159 Thr Gln Asp Gln Ile Leu Gln Thr Leu Ile Gln Arg Val Arg Arg Gln 705 710 715 aat ctt ctc tca gtt gtg ccg ccc tca cag ttc aac ttc gct cac tcau207n Ser Val Val Pro Pro Ser Gln Phe Asn Phe Ala His Ser 720 725 730 735 ggt ttc cag ctg gaa gac atc tcc aca agc cag agg ttc atg ctg ggt 2255 Gly Phe Gln Leu Glu Asp Ile Ser Thr Ser Gln Arg Phe Met Leu Gly 740 745 750 ttt gct ggc aga agg aca tcc aaa cct gca atg gca ggg cac tac tta 2303 Phe Ala Gly Arg Arg Thr Ser Lys Pro Ala Met Ala Gly His Tyr Leu 755 760 765 ctg aat att tct acc tac ggc cgg ggc tca gag agc ttt agg agg acc 2351 Leu Asn Ile Ser Thr Tyr Gly Arg Gly Ser Glu Ser Phe Arg Arg Thr 770 775 780 cat tct gta aac cct gaa gat cgt ttt tgt cta agc agc ccc act gaa 2399 His Ser Val Asn Pro Glu Asp Arg Phe Cys Leu Ser Ser Pro Thr Glu 785 790 790 795 gcc ttg aaa atg gga tat aca gac tgt aaa aat gca aca gga gag agt 2447 Ala Leu Lys Met Gly Tyr Thr Asp Cys Lys Asn Ala Thr Gly Glu Ser 800 805 810 815 815 agc agc agc aaa gaa gat gac act gat gag gaa agt act ggt gat gag 2495 Ser Ser Ser Lys Glu Asp Asp Thr Asp Glu Glu Ser Thr Gly Asp Glu 820 825 830 cag gaa tct gtc aca gtg aaa gag gag ccc cag gtt agt gct 2543 Gln Glu Ser Val Thr Val Lys Glu Glu Pro Gln Val Ser Gln Ser Ala 835 840 845 ggc aag ggt gac aca agt tca gga cct cac agc agg gaa act cta tct 2591 Gly Lys Gly Asp Thr Ser Ser Gly Pro His Ser Arg Glu Thr Leu Ser 850 855 860 acc agt gat tgc tta gct agc aag aat gtg aag gct gag ata cca ttg 2639 Thr Ser Asp Cys Leu Ala Ser Lys Asn Val Lys Ala Glu Ile Pro Leu 865 870 875 875 aat gag caa acc a ct tta agt aag gag aat tac ctg ttc act aga ggc 2687 Asn Glu Gln Thr Thr Leu Ser Lys Glu Asn Tyr Leu Phe Thr Arg Gly 880 885 890 895 caa aca ttt gat gaa aag acc cta gcc aga gat tta att cag gca gca 2735 Gln Thr Phe Asp Glu Lys Thr Leu Ala Arg Asp Leu Ile Gln Ala Ala 900 905 910 cag aag cag atg gct cat gca gtg aga ggt aag gca atc cgt agc agc 2783 Gln Lys Gln Met Ala His Ala Val Arg Gly Lys Ala Ile Arg Ser Ser 915 920 925 ccc gag ctt ttc agt tct act gtt ctt cct ctg cct gca gac agc ccc 2831 Pro Glu Leu Phe Ser Ser Thr Val Leu Pro Leu Pro Ala Asp Ser Pro 930 935 940 ACC cac cag ccc cta ctc ctt cca ccc ctg caa acc ccg aag ttg tat 2879 Thr His Gln Pro Leu Leu Leu Pro Pro Leu Gln Thr Pro Lys Leu Tyr 945 950 955 gga agc ccc acc cag ata ggg cca agc tat aga ggc atg atc aat gtc 2927 Gly Ser Pro Thr Gln Ile Gly Pro Ser Tyr Arg Gly Met Ile Asn Val 960 965 970 975 tcc acc tca tct gac atg gac cat aac tct gct gta cca ggt agc cag 2975 Ser Thr Ser Ser Ser Asp Met Asp His Asn Ser Ala Val Pro Gly Ser Gln 980 9 85 990 gta tct agc aat gta ggt gat gtc atg tca ttt tca gtg act gtc act 3023 Val Ser Ser Asn Val Gly Asp Val Met Ser Phe Ser Val Thr Val Thr 995 1000 1005 acc atc cct gct agc caa gct atg aat ccc agc agc cat ggc cag acc 3071 Thr Ile Pro Ala Ser Gln Ala Met Asn Pro Ser Ser His Gly Gln Thr 1010 1015 1020 att cct gtt cag gcg ttc tcc gaa gag aac agc ata gag ggc acg cct 3119 Ile Pro Val Gln Ala Phe Ser Glu Glu Asn Ser Ile Glu Gly Thr Pro 1025 1030 1035 tcg aaa tgt tac tgc cgc ttg aaa gcc atg atc atg tgc aaa ggc tgt 3167 Ser Lys Cys Tyr Cys Arg Leu Lys Ala Met Ile Met Cys Lys Gly Cys 1040 1045 1050 ct gg tgc cat gat gat tgc atc ggc ccc tcc aaa ctg tgc gtc 3215 Gly Ala Phe Cys His Asp Asp Cys Ile Gly Pro Ser Lys Leu Cys Val 1060 1065 1070 tcc tgc ctt gtc gtt cgg taatgagact agaaagagat Cyactgut 3263 ggagggggaa gggaagggtt gaccagttgg gttttttgcg tccttttgga atcacagaaa 3323 taaacaagta ggtttcagtt gtcttcagag acaaatgtta cttaatcagg aatacaaagt 3383 acagattttt tacat tttag aggaagagca ccttgtatag taagtctaag tcaagcaaga 3443 ctttgtgaat ttgtgacaag tttgcactta caaaatcatg taaatatgtc acattttgtt 3503 taacattatt tttccaagtg tttaggtaat aatgtattac tttgaattca gattaatgtt 3563 ctactacttg tgactgagaa aagtttaatg ccggcatggt aaaaggaagc tgtctccctt 3623 ctgacatttc ctaggaagct aggaaaagga aagtgaagga atggtctaaa gaaatgacca 3683 ttcacactga ttttgtctgg acagtctggc cgcaggttat tcatagatta ttcagccttt 3743 gcaggacttg gattcagggt tttactcagt ccctttacct taggtggaat cttcttaaat 3803 tgaaattttt ggtaaggaat tcatttcaca ggtagtgttt cagactctga aagccctgac 3863 ttggttcttg gcttctactg tactagttac tagttactgg tactgttgcc aagcaatctg 3923 cttggaattt gtggatccct gctgttccct aatcccaccc cctgccctga gacagtgaat 3983 gtagtccgtg aagggagtgc ctctctggga ccccctgtgt tgttacaggc tgtgcagtgc 4043 aacaattcca gcaaaaatac cctatccccg cacttagtca ttcgtggtaa ctaacaattt 4103 tgaaatactc atataaaatg aacaggaaag tgttagtgat tgggtgattt gagctacatc 4163 ttgttgagca aggggagtga aaccacagaa actgttaaat tgaacgtaaa taactttgga 4223 aaacagtttt gacactagaa caaggtcgct tctcttttcc tcttctctcc caacctgtta 4283 acctagtgct agatagtcag ctgctgttgc aggtagaaaa gctcaccaat gccacatttg 4343 ttcattctgt tcaacctgtt ttgacctccc aggcatctga acaggatgac atcatcttat 4403 tatatcttac tttacacata cgtgtatgta cacacacaca cacaatacaa gacatttttc 4463 ctgttttaga aaatatagcc cttgtttgga ttactgctgt ctgagcacta gaaatttcta 4523 atggaaagag gcctctgaat ggctaaggga acatctggaa aggaaggaaa atgagcccta 4583 aaggtttttt ggttgcttgt ttttgtttct ttttctttct tgtttccttt tttgttttta 4643 aatccttctc tagtgactga agaaattgtg agtacataat atttaggtca tggttaagga 4703 acattaaaat aaacctgcag tttaacagaa ttttgtatta aatgggggag tgtcaatttg 4763 catcatttgc atattgattt caagtctcct aatttggaat gggtaaagta caaatgttaa 4823 tgcaacatag tacagttgta tttgtccttc atattcagga tgtgatattt acaaaatgca 4883 gaacagttta aacttgttaa gtcacattcc agattaggag aaaatgggca ataatcatct 4943 ctgttttgcc cccattctac tacccaccac tgcccacccc acccccacat cacacactct 5003 tcgatgcttt cccacagccc ctgctccgct cctctccgta agaaactcac ttcactgttt 5063 ttcacttttc acttctggct ttttt gtggc ccaaggccaa tataggatta atatctgtgt 5123 tccagcttca gccagaacga tatgtctgtc catctttctc ctttcttcca gcacacacag 5183 ctaagagata agaaggctgc aaggattggg gataaggagt atattttcaa gccaagaacc 5243 agtagaaaac agaaataatg gtgctcccaa atattcagta ccttgggcaa tccaggaagg 5303 gtttaaagag acctgttgct gcatagaact ctccctgccc taccccttaa ctccacctta 5363 gtgccagggc cgagggctgg tctgcatgct ggaagaggtt gagagttttg gaattgattc 5423 catgctaaat gtcagttacc agtttggatt gatgaaagtg atttttctgc tttacctttt 5483 tcctgtcaga aaggttttcc tctgtgctac ccttaactta gggatgaaca gactataact 5543 aggaaaggag gaaaggtatc agggattttt aagtccgttt agagagcaaa ccatattgtg 5603 cctcttcatc ttgacccagg ctcttataga taggtcctaa acattgctgt tcactagatt 5663 atcttaacaa ataatactca gctaaatatt tgcatttagg aatactccta aaacagatat 5723 tgccaactag atacactgcc tcaatcttga ccagacaaga gaacagttaa gttctctcag 5783 ttgggtagta acttgaatac cagtctattt atcagttggt ttcaacacag aggtttcaag 5843 tggaaagcca ttcatcttaa aagctgaaca g 5874 <210> 83 <211> 5054 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (527) .. (3808) <400> 83 gggaaaaaaa aaaaaaactg tccaccaaga attctatacc taaatatctt ttaagtgaag 60 gtgacataaa gatgtttcca aacacacaac agctgaacta gttcattacc agcagacctt 120 cactgaaaga aatgttacag atgctttagg ctgaaggaaa acaaaaccat gtggaagtct 180 ggatctatac agaaaattga agagtactgg aaatggtaac tacatggatt caacacaact 240 gcaatcaaaa tcccagcagg ctattttgta gaaatcgaga agctgatcct gaaattcata 300 tagaaatgca aaggacctgg aataattaaa acaacttcaa caatgaaaag cagagtttgg 360 ggactcgcag tgcctgattg cagacccggt gcatttggac tcactgtggc gtggggtccc 420 agatgggagg aagcttcctg agaggtgacg cctgagttga gtctaagagg acaaggagtg 480 cggcaccttc ccgtctgatg ctggcgttgt gcgtatggtg ccctga cgt ctg tcc 535 Arg Leu Ser 1 acg tgg gcg cgg aag caa aca gcg atg tcc cag acg cag gac tac gag 583 Thr Trp Ala Arg Lys Gln Thr Ala Met Ser Gln Thr Gln Asp Tyr Glu 5 10 15 tgc agg agc cat aat gtc gac ctg ccg gag tcg agg att cca ggg tcg 631 Cys Arg Ser His Asn Val Asp Leu Pro Glu Ser Arg Ile Pro Gly Ser 20 25 30 35 aac act cgg ttg gag tgg gtg gag atc atc gaa ccg cgc acc cgc gag 67 9 Asn Thr Arg Leu Glu Trp Val Glu Ile Ile Glu Pro Arg Thr Arg Glu 40 45 50 cgc atg tac gcc aac ctg gtc acc ggt gag tgc gtg tgg gac ccg ccg 727 Arg Met Tyr Ala Asn Leu Val Thr Gly Glu Cys Val Trp Asp Pro Pro 55 60 65 gcc ggc gtc cgc atc aag cgc acc agc gag aac cag tgg tgg gag ctg 775 Ala Gly Val Arg Ile Lys Arg Thr Ser Glu Asn Gln Trp Trp Glu Leu 70 75 80 ttc gac ccc aac acg tcc cgc ttc tac tac tac aat gcc agc acg cag 823 Phe Asp Pro Asn Thr Ser Arg Phe Tyr Tyr Tyr Asn Ala Ser Thr Gln 85 90 95 cgc acg gtg tgg cac cgg ccg cag ggc tgc gac atc atc ccg ctg gcc 871 Arg Thr Val His Trp Arg Pro Gln Gly Cys Asp Ile Ile Pro Leu Ala 100 105 110 115 aag ctg cag acg ctg aag cag aac acg gag tcc ccg cgc gcc tcg gcg 919 Lys Leu Gln Thr Leu Lys Gln Asn Thr Glu Ser Pro Arg Ala Ser Ala 120 125 130 gag agc agc ccc ggg cgc ggc agc agc gtc agc cgt gag ggc agc acc 967 Glu Ser Ser Pro Gly Arg Gly Ser Ser Val Ser Arg Glu Gly Ser Thr 135 140 145 agc tcc tcc ctg gag ccc gag ccc gac actgag aaa g cag gag ttg 1 015 Ser Ser Ser Leu Glu Pro Glu Pro Asp Thr Glu Lys Ala Gln Glu Leu 150 155 160 cca gcg agg gcc ggg cgg ccc gcg gcg ttt ggg aca gtg aag gag gac 1063 Pro Ala Arg Ala Gly Arg Pro Ala Ala Phe Gly Thr Val Lys Glu Asp 165 170 175 agc ggc agc tct tca cca cca gga gtg ttc ctt gag aag gac tat gag 1111 Ser Gly Ser Ser Ser Pro Pro Gly Val Phe Leu Glu Lys Asp Tyr Glu 180 185 190 195 att tac cgg gat tac agt gcg gac ggc cag ctt ctt cac tac agg acc 1159 Ile Tyr Arg Asp Tyr Ser Ala Asp Gly Gln Leu Leu His Tyr Arg Thr 200 205 210 tcc tcg ctg cgg tgg aac tcg ggc gcc aaa gag cgc atg ctc atc aag 1207 Ser Ser Leu Ar Trp Asn Ser Gly Ala Lys Glu Arg Met Leu Ile Lys 215 220 225 gtc gct gat cgg gag ccc agc ttc ctc gcc gcc cag ggc aat ggc tac 1255 Val Ala Asp Arg Glu Pro Ser Phe Leu Ala Ala Gln Gly Asn Gly Tyr 230 240 gcc cca gac ggc cca cct ggg gtc cgc tcc cgc aga ccc tcc ggc agc 1303 Ala Pro Asp Gly Pro Pro Gly Val Arg Ser Arg Arg Pro Ser Gly Ser 245 250 255 cag cac tca ccc agc ctg cag acc ttc gcc ccg ga g gct gac ggc acc 1351 Gln His Ser Pro Ser Leu Gln Thr Phe Ala Pro Glu Ala Asp Gly Thr 260 265 270 275 atc ttc ttc cca gag agg agg ccg tca ccc ttc ctg aag agg gcc gag 1399 Ile Phe Phe Pro Glu Arg Arg Pro Ser Pro Phe Leu Lys Arg Ala Glu 280 285 290 ctc cca ggg agc agc tcc ccg ctg ctg gcc cag ccc cga aag ccc tcc 1447 Leu Pro Gly Ser Ser Ser Pro Leu Leu Ala Gln Pro Arg Lys Pro Ser 295 300 305 ggg gac tcg cag ccc tcc tcc ccg cgc tat ggc tat gaa ccc ccg ctc 1495 Gly Asp Ser Gln Pro Ser Ser Pro Arg Tyr Gly Tyr Glu Pro Pro Leu 310 315 320 tac gag gag ccc cca gtg gag tac cag gcc ccc atc tac gat cag 1543 Tyr Glu Glu Pro Pro Glu Tyr Gln Ala Pro Ile Tyr Asp Glu Pro 325 330 335 ccc atg gac gtg caa ttc gag gct ggc ggg ggc tac cag gcc ggc tct 1591 Pro Met Asp Val Gln Phe Glu Ala Gly Gly Gly Tyr Gln Ala Gly Ser 340 345 350 350 355 ccc cag cgg tcg ccg ggc cgt aag ccc cgg ccg ttc ctc cag ccc aac 1639 Pro Gln Arg Ser Pro Gly Arg Lys Pro Arg Pro Phe Leu Gln Pro Asn 360 365 370 aag cag ggc ccc ccc tcg ccc tgc cag cag ctg gtg ctc acc aag cag 1687 Lys Gln Gly Pro Pro Ser Pro Cys Gln Gln Leu Val Leu Thr Lys Gln 375 380 385 aag tgt ccc gag cgc ttc ctg agc ctg gag tac agt ccc gcc ggc aag 1735 Glu Arg Phe Leu Ser Leu Glu Tyr Ser Pro Ala Gly Lys 390 395 400 gag tac gtg cgg cag ctg gtc tac gtg gag cag gcg ggc tcc agc ccc 1783 Glu Tyr Val Arg Gln Leu Val Tyr Val Glu Gln Ala Gly Ser Ser Pro 405 410 415 aag ctg cgc gcc ggc ccg cgg cac aag tac gcg ccc aac ccc ggc ggt 1831 Lys Leu Arg Ala Gly Pro Arg His Lys Tyr Ala Pro Asn Pro Gly Gly 420 425 430 435 435 ggt tcg tac tcc ttg cag ccc agc ctg agg gac cag cgc 1879 Gly Ser Tyr Ser Leu Gln Pro Ser Pro Cys Leu Leu Arg Asp Gln Arg 440 445 450 ctg ggc gtc aag tcc gga gac tac agc acc atg gag gga cct gag ctg 1927 Leu Gly Val Lys Ser Gly Aspyr Ser Thr Met Glu Gly Pro Glu Leu 455 460 465 cgg cac agc cag ccg ccc acg ccg ctg cca cag gcc cag gag gat gcc 1975 Arg His Ser Gln Pro Pro Thr Pro Leu Pro Gln Ala Gln Glu Asp Ala 470 475 475 480 atg tcc tgg tcc agc cag cag gac acc ctg tcc tcc aca ggc tac tcc 2023 Met Ser Trp Ser Ser Gln Gln Asp Thr Leu Ser Ser Thr Gly Tyr Ser 485 490 495 ccg ggc acg cgc aag cgg aag agc aga aag ccc tct ttg tg gcc 2071 Pro Gly Thr Arg Lys Arg Lys Ser Arg Lys Pro Ser Leu Cys Gln Ala 500 505 510 acc agc gcc acc ccc act gag ggc ccc ggg gac ctg ctt gtg gag cag 2119 Thr Ser Ala Thr Pro Thr Glu Gly Pro Gly Asp Leu Leu Val Glu Gln 520 525 530 ccc ctg gcc gag gaa cag ccc ccg tgc ggg acc agc ctc gcc ccc gtg 2167 Pro Leu Ala Glu Glu Glu Pro Pro Cys Gly Thr Ser Leu Ala Pro Val 535 540 545 aag cga gcg gag g gcc gaa ggg gcg cgg ggc gcg gcc gag ccc 2215 Lys Arg Ala Glu Gly Glu Ala Glu Gly Ala Arg Gly Ala Ala Glu Pro 550 555 550 ttc ctg gcg cag gct cgg ctg gcc tgg gag gcg cag cag gcc cg cag gacc Gln Ala Arg Leu Ala Trp Glu Ala Gln Gln Ala His Phe 565 570 575 cac atg aag cag agg agc agc tgg gac tcc cag cag gac ggc tct ggc 2311 His Met Lys Gln Arg Ser Ser Trp Asp Ser Gln Gln Asp Gly Ser Gly 580 585 590 595 595 tac gag agc gac ggc gcc ctg cca ctg ccc atg ccc ggg ccg gtg gtg 2359 Tyr Glu Ser Asp Gly Ala Leu Pro Leu Pro Met Pro Gly Pro Val Val 600 605 610 cgg gcc ttc agc gag gag gag gag gcc cag cag gag aac agg cac 2407 Arg Ala Phe Ser Glu Asp Glu Ala Leu Ala Gln Gln Glu Asn Arg His 615 620 625 tgg agg agg ggc acc ttc gag aag cta ggc ttc ccc cag atc ctg ctg 2455 Trp Thrg Arg Glu Lys Leu Gly Phe Pro Gln Ile Leu Leu 630 635 640 gag aag agc gtc tcc gtg cag acc aac ctg gcc tca cca gag ccc tac 2503 Glu Lys Ser Val Ser Val Gln Thr Asn Leu Ala Ser Pro Glu Pro Tyr 645 650 655 ctc cac ccc tca cag tct gag gac ctc gct gcc tgt gcc cag ttc gag 2551 Leu His Pro Ser Gln Ser Glu Asp Leu Ala Ala Cys Ala Gln Phe Glu 660 665 670 675 agc agc cgg cag agc cgc agc ggc gtt ccc agc ccc gtc ttc 2599 Ser Ser Arg Gln Ser Arg Ser Gly Val Pro Ser Ser Ser Cys Val Phe 680 685 690 ccc act ttc acg ctg cgc aag ccc tcc tcg gag acg gac atc gag aac 2647 Pro Thr Phe Thr Leu Arg Lys Pro Ser Ser Glu Thr Asp Ile Glu Asn 695 700 705 tgg gcc tcc aag cac ttc aac aag cac acg cag ggc ctc ttc cgg cgg 2695 Trp Ala Ser Lys His Phe Asn Lys His Thr Gln Gly Leu Phe Arg Arg 710 715 720 aag gtg tcc atc gcc aac atg ctg gcc tgg agc agc gag tcc atc aag 2743 Lys Val Ser Ile Ala Asn Met Leu Ala Trp Ser Ser Glu Ser Ile Lys 725 730 735 aag ccc atg atc gtg aca agc gac cgg cac gtg aag aag gag gcc tg Pro Met Ile Val Thr Ser Asp Arg His Val Lys Lys Glu Ala Cys 740 745 750 755 gag ctc ttc aag ctg atc cag atg tac atg ggt gac cgg cgg gcc aag 2839 Glu Leu Phe Lys Leu Ile Gln Met Tyr Met Gly Asp Arg Arg Ala Lys 760 765 770 gcc gac cca ctg cac gtg gcc ctg gag gtg gcc acc aag ggc tgg agc 2887 Ala Asp Pro Leu His Val Ala Leu Glu Val Ala Thr Lys Gly Trp Ser 775 780 785 gtg cag ggc ctg cgg gac gag atc cag ctg tgc cgg cag acc 2935 Val Gln Gly Leu Arg Asp Glu Leu Tyr Ile Gln Leu Cys Arg Gln Thr 790 795 800 acc gag aac ttc cgc ctg gag agc ctg gcc cgc ggc tgg gag ctc atg 2he Thr Glun Arg Leu Glu Ser Leu Ala Arg Gly Trp Glu Leu Met 805 810 815 gcc atc tgc ctg gcc ttt ttc ccg ccc acc ccc aag ttc cac tcc tac 3031 Ala Ile Cys Leu Ala Phe Phe Pro Pro Thr Pro Lys Phe His Ser Tyr 820 825 830 835 ctg gaa ggc tac atc tac cgg cac atg gac ccc gtc aat gac act aaa 3079 Leu Glu Gly Tyr Ile Tyr Arg His Met Asp Pro Val Asn Asp Thr Lys 840 845 850 ggg gtg gcg ata agc acg tat ggt aac tac cac aag cta cag 3127 Gly Val Ala Ile Ser Thr Tyr Ala Lys Tyr Cys Tyr His Lys Leu Gln 855 860 865 aag gca gcc ctg acc ggg gcc aag aag ggg ctg aag aag ccc aac gtg 3175 Lys Ala Ala Leu Thr Gly Ala Lys Lys Gly Leu Lys Lys Pro Asn Val 870 875 880 gag gag atc cgg cat gcc aag aac gcc gtg ttc agc ccg tcc atg ttc 3223 Glu Glu Ile Arg His Ala Lys Asn Ala Val Phe Ser Pro Ser Met Phe 885 890 895 895 ggc agc gca cag gag gtc atg ggc atg cag aga gag cgc tac ccc 3271 Gly Ser Ala Leu Gln Glu Val Met Gly Met Gln Arg Glu Arg Tyr Pro 900 905 910 915 gag cgc cag ctg ccc tgg gtg cag aca cgg ctc tct gag gag g 3319 Glu Arg Gln Leu Pro Trp Val Gln Thr Arg Leu Ser Glu Glu Val Leu 920 925 930 gcg ctc aac ggt gac cag aca gag ggc atc ttc agg gtc cct ggg gac 3367 Ala Leu Asn Gly Asp Gln Thr Glu Gle Ile Phe Arg Val Pro Gly Asp 935 940 945 att gac gag gtg aat gcc ctg aag ctg cag gtg gac cag tgg aag gtg 3415 Ile Asp Glu Val Asn Ala Leu Lys Leu Gln Val Asp Gln Trp Lys Val 950 955 960 ccc aca ggc gcc gcc cac gtc cct gcg tcc ctg ctg aag ctg 3463 Pro Thr Gly Leu Glu Asp Pro His Val Pro Ala Ser Leu Leu Lys Leu 965 970 975 tgg tac cgg gag ctg gag gag ccc ctg atc ccg cac gag ttc tac gag 35g Trp Tyr Leu Glu Glu Pro Leu Ile Pro His Glu Phe Tyr Glu 980 985 990 995 cag tgc atc gcg cac tac gac agc ccc gag gcg gcg gtg gcc gtg gtg 3559 Gln Cys Ile Ala His Tyr Asp Ser Pro Glu Ala Ala Val Ala Val 1000 1005 1010 cac gcg ctg ccc cgc atc aac cgc atg gtg ctg tgc tac ctc atc cgc 3607 His Ala Leu Pro Arg Ile Asn Arg Met Val Leu Cys Tyr Leu Ile Arg 1015 1020 1025 ttc ctg cag gtc ttg aac gtc gcg gtc acc aag atg 3655 Phe Leu Gln Val Phe Val Gln Pro Ala Asn Val Ala Val Thr Lys Met 1030 1035 1040 gat gtc agc aac ctg gcc atg gtg atg gcg ccc aac tgc ttg cgc tgc 3703 Asu Val Ser Ser Met Val Met Ala Pro Asn Cys Leu Arg Cys 1045 1050 1055 cag tcc gac gac ccg cgc gtc atc ttc gag aac acc cgc aag gag atg 3751 Gln Ser Asp Asp Pro Arg Val Ile Phe Glu Asn Thr Arg Lys Glu Met 1060 1065 1075 tcc ttc ctg cgg gtg ctc atc cag cac ctg gac acc agc ttc atg gag 3799 Ser Phe Leu Arg Val Leu Ile Gln His Leu Asp Thr Ser Phe Met Glu 1080 1085 1090 ggt gtg ctg tagcgggggc gcccgggg cccgccccgcc aggagccgcc aggagccgcc cccggcagag gggccagaat cgcccggccc 3908 agccctggag ccccctccac tcccccaggc ccctggcccc ggcgctcccc acgtcttctg 3968 cctggtctga gggtgcagcc agggcacagc agcggcgggg agggcgcctc tggcccccca 4028 cctcacggcc agttcccgcg ggcaccgcct cgccctccgc tggccgcggg tcagctccga 4088 gaaagtgcct tctgtgtcct ggagccgagc gacgctgcct ccttggggcc gggctgcctc 4148 cctgtggctc ctgcgcgccc tggcctgggc cttgcccagc cgccccggtc tctccttccc 4208 tttctcctgt cctcgtcctg gcctgcagct cttcccagcc ccgagagagc ttcccgacct 4268 gtccccgcct cctctccctc cctcggcccg tggtccccag ctggtgactg ctcaggagtt 4328 tgggggctcc aggacagtgg gcccggggcc tggcaggctc tcggtgggtg gggtgggggc 4388 ccccaaacca aagtcctctg gggtagggag cagggctggg caggcattct gggggcaggg 4448 tgggggaggg gcgagagtat ttttttcttc gtgtaactgt aaatccagaa tctatcctgc 4508 atcgcagccc accgtgtata gagatataaa tagagggaaa gatataagaa ctaaatttgc 4568 taatgacata gttttaacct aaatgctatt tatctctgag ccgtccccgt cctccgtgca 4628 gagcaagttg aggtcattcc ttcttttctt ctccgatctt ttttcttggc ttctgaccaa 4688 aaaccaagct ctaccccatc cccatcccag acctgcagga gacgagcgag cgggaaggcg 4748 ccgggcccgg gactgtccgt tctcggggcc agagctgctg ggggaccgag tttgtacatt 4808 ttccattttg gaattttgag ttccaattgt tgtaaaactt aatttctccc cagtttttat 4868 atatatattt tttagagttc cgtttttatt tattaaaaac aaaagcccca gccctgccga 4928 ggcctgggcg gcgtcctcag tcgggtggtc ccggggcctt tgcggtcccg cccggctgag 4988 acgctcgccc cgac gcatgg acccgagagg cgacgacacg agtgaataaa gtgcacatgg 5048 accctg 5054 <210> 84 <211> 4803 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2276) .. (4234) <400> 84 gggattgttc agaggcaaag tattggaatc tatcaatgaa cagatagtct ttgatctcta 60 ctccgttgac acttccttga atgtaaaaat aatttttaga gtgtggtact ttttgtttta 120 taaaaagtat gtatcagtct gaatgtttgt ttgcttcata aatcaaaaca tttccatatt 180 tttgaaatta catcagtgtt ttaaaattca acttcctaga ttaaatttta cagttgaatg 240 ttttgtctca gtattttgcc tagttcttat ttcttgtcta acagaaacta agcactttgg 300 ggggccgagg tgcgcagatc acctgaggtc aggagtttga gaccggcctg gccggcatgg 360 cgaaaccctg tctctactaa aagtacaaaa attagccagg agtggtggcg ggtgcctgta 420 gtcccagcta ctcaggaggc tgaggcagga caatcgcttg aacccgggag gcggaggttg 480 cggtgggctg agattgcgcc actgtactcc agcctgggcg acaagagtga gactccagcg 540 caaaaaaaaa aaagggcggg ggggctaaag cataaagagg tgagcataat tttaaagaat 600 tactaagttc agtttaacta gagtagctaa aatttgaaag acttgctcat tatgtgaaga 660 taagtgattc cagtaaacaa gcaaaaatca ctgagaaaag tacattaata atgttagaaa 720 aacctaatct taatttacta ttaaaaatat tcatcttatt ctgtcctctt ttcacagttt 780 ttaccaaagt caaatgtttt tgctagcttt ggagcactgt taactatagt cctatctgtg 840 gtaatgctat aatgcccaaa ttgatagttt tataatgcta gtgcttaagt tatttggaga 900 aatttggctg gatgggggca gagcaggtca ggcagatctt acactgcctg gaactgcaaa 960 tctataggtg gcaagaggga attgctttct aaattgaatg ctccatttcc ttaacaagac 1020 tggtccagga ccaagccaag cttaggtaaa tgggcttgga atacagcctt tctggggaat 1080 ttgctatggc ttttgagtcc ttgtgatttg gaaaacatct ggatataaag agatgtttat 1140 agctgatctg aatatatatg tgatctccct gaagtaagta actacagatc agccgaagaa 1200 cctcctctga ctacttagga ttctcttcaa gcgtgtcaat cagctagaac gtgaccattc 1260 tctgagcgtt gaacacttta cattgccaga taatttgtgc tgttttcgtc aaacctgacc 1320 ctaatataac ttgactaaat aatcttgtct gtggcaaata aagaggtagc agtatattta 1380 tgtcctcttt tcggaaggtg ataaaggaat tatttgataa agtacgatat gtattgctac 1440 tttgcagagt agacctcaag tagatacttg agtagacact ctgcatttgt gtgctttttt 1500 ctattcacac actacagtgg gtatgtgaat cagtgaaaaa ttgccaaaaa tatgatcaat 1560 tgaaaacttt tgttaggtgg tctttatttg aactatatct tgtcatccat tagtaattta 1620 gcaagatttg atcagaacca gtcaacgctc tttaaatcag ttaatcccat taaaggtttt 1680 tatggaaagg aaaaacag tg ctcaacaatt gagttgatac taaagctttg ctttgaccaa 1740 attgcagtta ataccagtaa actacttttt ttttttgaga cggagtcttg ctctgtcacc 1800 cagactggag tgcagtgacg ctgtcttggc tcactgcaag ctctgcctcc cgggttcaca 1860 tcattctcct gcctcagctt cctgagtggc tggggctata ggcacccgtc accacgcctg 1920 gttaattttt ttttagtaca gatggggttt cgccgtgttg gccaggatgg tctcgatctc 1980 ctgacctcgt gatctgccag cctcggcctc ccagagtgct gggattgcag gcgtgagcca 2040 ccgtgcccag cctatcagtc aactactttt tgtttttatc ttcatatatt aagggaattt 2100 ttagttaaac aggttgccct cacatacatt ttatgatctt atattagata cctttggatg 2160 tctgtatttt ttagtaggca gatgaaagtg tttttagtta ggattatagg gattgcttta 2220 gtaaaataat atttcctcag agaatctgtc ttactccaac aaatactaac tctaa gg tt g tt ag t tt ag t tt g tt ag tt g Asn Lys Val Ile Thr 5 10 15 tta tgg tac cgt cca cct gaa ctg cta ctg gga gaa gaa cga tac aca 2374 Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr 20 25 30 cca gcc att gat gta tgg agc tgt ggc tgt atc ctt ggc gaa ctc ttc 2422 Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe 35 40 45 act aaa aaa cct ata ttt caa gca aat cag gaa ctt gca caa cta gaa 2470 Thr Lys Pro Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu 50 55 60 65 tta ata agc cga ata tgt ggg agt cca tgt cct gca gtg tgg cct gat 2518 Leu Ile Ser Arg Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp 70 75 80 gta atc aaa cta cca tat ttc aac acc atg aaa cca aag aag caa tat 2566 Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr 85 90 95 cgt cga aag tta aga gaa gaa ttt gtt ttt att cct gca gct gcg cta 2614 Arg Arg Lys Leu Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu 100 105 110 gac tta ttt gat tac atg ctt gcc ttg gat cct agt aag cgc tgc act 2662 Asp Leu Phe Asp Tyr Met Le Ala Leu Asp Pro Ser Lys Arg Cys Thr 115 120 125 gct gaa cag gct ctt cag tgc gag ttc ctc cga gat gtg gaa ccc tca 2710 Ala Glu Gln Ala Leu Gln Cys Glu Phe Leu Arg Asp Val Glu Pro Ser 130 135 140 145 aaa atg cc t cca cca gat ctc cct tta tgg caa gat tgt cat gag tta 2758 Lys Met Pro Pro Pro Asp Leu Pro Leu Trp Gln Asp Cys His Glu Leu 150 155 160 tgg agt aaa aag cga aga aga cag aag cag atg ggc atg act gat gat gat 2806 Trp Ser Lys Lys Arg Arg Arg Gln Lys Gln Met Gly Met Thr Asp Asp 165 170 175 gtt tcc aca att aaa gcc ccc agg aag gac ttg tct ctg ggc ttg gat 2854 Val Ser Thr Ile Lys Ala Pro Arg Lys Asp Leu Ser Leu Gly Leu Asp 180 185 190 gac agc aga acc aac aca ccc cag ggt gtg ctg cca tct tca cag ctg 2902 Asp Ser Arg Thr Asn Thr Pro Gln Gly Val Leu Pro Ser Ser Gln Leu 195 200 205 aaa tct cag ggc agc tca aat gtg gca cct gta aaa aca ggc cct gga 2950 Lys Ser Gln Gly Ser Ser Asn Val Ala Pro Val Lys Thr Gly Pro Gly 210 215 220 225 cag cac tta aac cac agt gaa ttg gca att cta cta aac cta cta caa 2998 Gln His Leu Asn His Ser Glu Leu Ala Ile Leu Leu Asn Leu Leu Gln 230 235 240 tct aaa aca agt gtt aat atg gct gat ttt gtc caa gtg ttg aac att 3046 Ser Lys Thr Ser Val Asn Met Ala Asp Phe Val Gln Val Leu Asn Ile 24 5 250 255 aag gta aac tct gag act caa cag cag cta aat aaa ata aac ctt cct 3094 Lys Val Asn Ser Glu Thr Gln Gln Gln Leu Asn Lys Ile Asn Leu Pro 260 265 270 gct gga att ttg gca aca ggt gaa aaa cag aca gat cca tca aca cca 3142 Ala Gly Ile Leu Ala Thr Gly Glu Lys Gln Thr Asp Pro Ser Thr Pro 275 280 285 caa cag gag tct tcg aaa ccg ttg gga gga att cag cct tct tct cag 3190 Gln Gln Glu Ser Ser Lys Pro Leu Gly Gly Ile Gln Pro Ser Ser Gln 290 295 300 305 acc atc cag cct aaa gtg gag act gat gct gcc cag gcg gct gtg cag 3238 Thr Ile Gln Pro Lys Val Glu Thr Asp Ala Ala Gln Ala Ala Val Gln 310 315 320 agt gca ttt gca gtt ctg ttg act cag tta ata aag gct cag cag tca 3286 Ser Ala Phe Ala Val Leu Leu Thr Gln Leu Ile Lys Ala Gln Gln Ser 325 330 335 aag cag aaa gat gtg cta cta gaa gag agg gaa aat gga tcg 3334 Lys Gln Lys Asp Val Leu Leu Glu Glu Arg Glu Asn Gly Ser Gly His 340 345 350 gaa gcg tca tta caa ctc agg cca cct cca cga gaa cct agc act ccg gtg 3382 Glu Ala Ser Leu Gln Leu Arg Pro Pro Glu Pr o Ser Thr Pro Val 355 360 365 tcg gga caa gat gac ctc atc cag cat caa gat atg agg atc ttg gag 3430 Ser Gly Gln Asp Asp Leu Ile Gln His Gln Asp Met Arg Ile Leu Glu 370 375 380 385 cta acg cca gaa cca gac cgg cct cga att ctg cct cct gac caa cga 3478 Leu Thr Pro Glu Pro Asp Arg Pro Arg Ile Leu Pro Pro Asp Gln Arg 390 395 400 cct ccc gag cct cct gaa cca cca cca gtc act gag gaa gat cta gat 3526 Pro Pro Glu Pro Pro Glu Pro Pro Pro Val Thr Glu Glu Asp Leu Asp 405 410 415 tat cgg aca gaa aac cag cat gta ccc acc acc agt tct tca tta act 3574 Tyr Arg Thr Glu Asn Gln His Val Pro Thr Thr Ser Ser Ser Leu Thr 420 425 430 gac cct cat gcc gga gtg aag gca gcc ctg tta cag ctg ctt gct cag 3622 Asp Pro His Ala Gly Val Lys Ala Ala Leu Leu Gln Leu Leu Ala Gln 435 440 445 cat cag ccc cag gat gac ccc aaa aga gag ggg att gat tat caa 3670 His Gln Pro Gln Asp Asp Pro Lys Arg Glu Gly Gly Ile Asp Tyr Gln 450 455 460 465 gca gga gac act tac gtg tcc act tca gac tac aag gac aac ttt gga 3718 Ala Gly Asp Thr Tyr Va l Ser Thr Ser Asp Tyr Lys Asp Asn Phe Gly 470 475 480 tcc tct tct ttc tct tct gct cct tat gtt agc aat gat ggt cta gga 3766 Ser Ser Ser Phe Ser Ser Ala Pro Tyr Val Ser Asn Asp Gly Leu Gly 485 490 495 495 agc agt tct gct cca cca cta gaa cga cgt agt ttc att gga aat tca 3814 Ser Ser Ser Ala Pro Pro Leu Glu Arg Arg Ser Phe Ile Gly Asn Ser 500 505 510 gat att cag tct ttg gat aac tac agt act gct tca tct cat tct ggt 3862 Asp Ile Gln Ser Leu Asp Asn Tyr Ser Thr Ala Ser Ser His Ser Gly 515 520 525 ggt cca cct cag cct tct gcc ttt tct gag tca ttt ccc agt tca gta 3910 Gly Pro Pro Gln Pro Ser Ala Phe Ser Glu Ser Phe Pro Ser Ser Val 530 535 540 545 gct gga tat gga gac att tac ctc aat gct ggt ccc atg ttg ttt agt 3958 Ala Gly Tyr Gly Asp Ile Tyr Leu Asn Ala Gly Pro Met Leu Phe Ser 550 555 560 gga gac aag gac cat aga ttt gaa tat agc cat ggt cct att gca gtc 4006 Gly Asp Lys Asp His Arg Phe Glu Tyr Ser His Gly Pro Ile Ala Val 565 570 575 ctg gca aac agc agt gac cct tcc acg ggg cca gag agt act cat cct 4054 Leu Ala Asn Ser Ser Asp Pro Ser Thr Gly Pro Glu Ser Thr His Pro 580 585 590 ttg cca gca aag atg cac aac tat aac tat ggt ggt aac tta cag gaa 4102 Leu Pro Ala Lys Met His Asn Tyr Asn Tyr Gly Gly Asn Leu Gln Glu 595 600 605 aat ccg agt ggc ccc agc ctc atg cat gga cag acc tgg act tct cct 4150 Asn Pro Ser Gly Pro Ser Leu Met His Gly Gln Thr Trp Thr Ser Pro 610 615 620 625 625 gcc caa gga cct gga tat tca caa gga tac agg gga cat att agc aca 4198 Ala Gln Gly Pro Gly Tyr Ser Gln Gly Tyr Arg Gly His Ile Ser Thr 630 635 640 tca act ggc aga ggc aga ggc aga ggg tta cca tac tgagtatctg 4244 Ser Thr Gly Arg Gly Arg Gly Arg Leu Pro Tyr 645 650 tttttcctca ggcacatcat ttttatctgg aaagactttt ctagctgcaa tttaaggcag 4304 caatccaaga gacttgaata ataataattc agcaacagct ttatttttat gtggagaagg 4364 gtcttgcata caatagttta aaaaagacaa aaaaaacctt tgcttaaatt catgctgttc 4424 taaaaactag atcgattgta catcttcaca aattctagtt aacaatttta ttttgtattc 4484 ttgcagtttt aagtggatgc taattttagg ggcataagcc ttttatggcc ctcttgcaga 4544 tcttctgaac ta tgcacatt tgtgcttttt ttgtaagttt ggaccaactt ttatgtaaca 4604 aacagcccct ccccacctcc agttttacaa caatcagaaa gggcactgat ttatttggta 4664 tttttctttt tacaaagcta cctttagtca aaggtcactg tcagtctttg cacctgcttt 4724 cagtgttatt gtgaaaggtg tactttgtgc tcatttcaga aaataaaaca caacctttct 4784 cttgatgcaa cagttttat 4803 <210> 85 <211> 5068 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2133) <400> 85 gtt tct gct cag att gag gaa aca atg gaa gag ctt gaa ata act gtg 48 Val Ser Ala Gln Ile Glu Glu Thr Met Glu Glu Leu Glu Ile Thr Val 1 5 10 15 aat gtc cca gat gta gga tgc ata gct gtt gtt gaa cat gag cta cca 96 Asn Val Pro Asp Val Gly Cys Ile Ala Val Val Glu His Glu Leu Pro 20 25 30 aac aca gat gtg act act gaa gaa atg aaa caa gaa gaa aat ttg agt 144 Asn Thr Asp Val Thr Thr Glu Glu Met Lys Gln Glu Glu Asn Leu Ser 35 40 45 gta ccg ttt gaa atg acc aca agt gaa cat atc caa gat gaa cca ggt 192 Val Pro Phe Glu Met Thr Thr Ser Glu His Ile Gln Asp Glu Pro Gly 50 55 60 acc aat gat gga agc acc gaa gct gca ata act tta ctt aca atg gga 240 Thr Asn Asp Gly Ser Thr Glu Ala Ala Ile Thr Leu Leu Thr Met Gly 65 70 75 80 gat cta gta ttg cag tca gag atc agt agt gaa cag ggt gat gta gga 288 Asp Leu Val Leu Gln Ser Glu Ile Ser Ser Glu Gln Gly Asp Val Gly 85 90 95 gta tgt ata ctt cct cat gtt cat tca aag gat aaa agc cat att cct 336 Val Cys Ile Leu Pro His Val His Ser Lys Asp Lys Ser His Ile Pro 100 105 110 tct agc cta gat aat gta aat cac aaa att gtt cat gaa tgt cag gaa 384 Ser Ser Leu Asp Asn Val Asn His Lys Ile Val His Glu Cys Gln Glu 115 120 125 ctt tct tca cct gtc att act aca tct cct gca tca ttt gaa gaa aac 432 Leu Ser Ser Pro Val Ile Thr Thr Ser Pro Ala Ser Phe Glu Glu Asn 130 135 140 aag att gta ttg gag gaa caa agt tcc aga gaa gaa ata agt tta atg 480 Lys Ile Val Leu Glu Glu Gln Ser Ser Arg Glu Glu Ile Ser Leu Met 145 150 155 160 gag aaa gta aag gag aat gct aca cca acc agg aat aca att tct aaa 528 Glu Lys Val Lys Glu Asn Ala Thr Pro Thr Arg Asn Thr Ile Ser Lys 165 170 175 gtg acc agt aat ttg aga ata aga agt agg ctt gct aag cct aaa cca 576 Val Thr Ser Asn Leu Arg Ile Arg Ser Arg Leu Ala Lys Pro Lys Pro 180 185 190 aat ctt gag aag act tta ggg acc aac agg ctt gat gat tat cag gaa 624 Asn Leu Glu Lys Thr Leu Gly Thr Asn Arg Leu Asp Asp Tyr Gln Glu 195 200 205 gtt tcc agt ttg tgt gta acc aaa ggg gca gaa atg gaa act caa aga 672 Val Ser Ser Leu Cys Val Thr Lys Gly Ala Glu Met Glu Thr Gln Ar g 210 215 220 gaa aca gag aaa aat gct tcc aaa gca aca gaa ttg gaa aat aaa aac 720 Glu Thr Glu Lys Asn Ala Ser Lys Ala Thr Glu Leu Glu Asn Lys Asn 225 230 235 240 ctt gga cca gtt aca aca gca gag aat aag gat cag agc aaa ttg gca 768 Leu Gly Pro Val Thr Thr Ala Glu Asn Lys Asp Gln Ser Lys Leu Ala 245 250 255 tgt gta cat ggt atc aaa ggg acc agt att tct tca gaa gta aac cta 816 Cys Val His Gly Ile Lys Gly Thr Ser Ile Ser Ser Glu Val Asn Leu 260 265 270 270 act gaa aga aac gaa aat caa gaa gag agc tct cag gag gtt cac atg 864 Thr Glu Arg Asn Glu Asn Gln Glu Glu Ser Ser Gln Glu Val His Met 275 280 285 285 ttg tca gtt gct cca gtt gct tcc tct gag aca ggg ccc tgc aca ctt 912 Leu Ser Val Ala Pro Val Ala Ser Ser Glu Thr Gly Pro Cys Thr Leu 290 295 300 ggt ttg gat agg ggt ctt ggt gaa aat tct gtt gaa gag ccc cag ata 960 Gly Leu Asp Arg Gly Leu Gly Glu Asn Ser Val Glu Glu Pro Gln Ile 305 310 315 320 aag gac tct aaa gga gac agt gtg ctt aca ctt cct gtg cca gag tat 1008 Lys Asp Ser Lys Gly Asp Ser Val Leu Thr Leu P ro Val Pro Glu Tyr 325 330 335 aca cca aca agt att cca gaa gtc caa caa gag aat ata atc aat cct 1056 Thr Pro Thr Ser Ile Pro Glu Val Gln Gln Glu Asn Ile Ile Asn Pro 340 345 350 350 caa gac cta aca gtg aat cta gtt gct aat gta cct caa gat gga gaa 1104 Gln Asp Leu Thr Val Asn Leu Val Ala Asn Val Pro Gln Asp Gly Glu 355 360 365 gat gaa caa gcc ttt att tta act ctg gtg gaa atc cca gcc aat gca 1152 Asp Glu Ala Phe Ile Leu Thr Leu Val Glu Ile Pro Ala Asn Ala 370 375 380 gta gaa gaa ttt act gat gcc act gca cag ttc atg cca aac cct tta 1200 Val Glu Glu Phe Thr Asp Ala Thr Ala Gln Phe Met Pro Asn Pro Leu 385 390 395 400 ctg cca gct ccc ata ttg gtc aaa tca gtg aat acc gaa gaa agg ggt 1248 Leu Pro Ala Pro Ile Leu Val Lys Ser Val Asn Thr Glu Glu Arg Gly 405 410 415 gac atg agt att tgt tta cca gca act tca gtt ggt caa gat gcc atg 1296 Asp Met Ser Ile Cys Leu Pro Ala Thr Ser Val Gly Gln Asp Ala Met 420 425 430 ggt tta tct att tct gga aga gat aat tct aaa aag cct cct gat aat 1344 Gly Leu Ser Ile Ser Gly A rg Asp Asn Ser Lys Lys Pro Pro Asp Asn 435 440 445 ttg gat ctt gta tct agg aag aga ttt caa tgc agg ctt gat aaa aat 1392 Leu Asp Leu Val Ser Arg Lys Arg Phe Gln Cys Arg Leu Asp Lys Asn 450 455 460 gac cac att cct cct gcc aaa aaa cgt tca ctc act tta aga gat gac 1440 Asp His Ile Pro Pro Ala Lys Lys Arg Ser Leu Thr Leu Arg Asp Asp 465 470 475 475 480 tgt caa gaa tat acc act gag gtg cac tca aag gaa tta aca aat gtt 1488 Cys Gln Glu Tyr Thr Glu Val His Ser Lys Glu Leu Thr Asn Val 485 490 495 ttt gag gaa aca ggg gag tct cac aag gga caa gat att ttt ctt acc 1536 Phe Glu Glu Glu Thr Gly Glu Ser His Lys Gly Gln Asp Ile Phe Leu Thr 500 505 510 tca gga agc aca ctg aca act cca gaa cct caa aga cag caa gtt gaa 1584 Ser Gly Ser Thr Leu Thr Thr Pro Glu Pro Gln Arg Gln Gln Val Glu 515 520 525 gca gct ttt cag agt aga gga tct aga tct cct gat gca tgc atg gac 1632 Ala Ala Phe Gln Ser Arg Gly Ser Arg Ser Pro Asp Ala Cys Met Asp 530 535 540 aag aat gtg cct cag tta cct cag gat gaa atg att gtg tct gat aag 1680 Lys n Val Pro Gln Leu Pro Gln Asp Glu Met Ile Val Ser Asp Lys 545 550 555 560 gaa gaa aga act gat gct gct cct aag tct cag caa atg gat agc aga 1728 Glu Glu Arg Thr Asp Ala Ala Pro Lys Ser Gln Gln Met Asp Ser Arg 565 570 575 aca tcg tct tct aaa gcc tca cta tcc aga cct ggc aga aga ccc ctg 1776 Thr Ser Ser Ser Lys Ala Ser Leu Ser Arg Pro Gly Arg Arg Pro Leu 580 585 590 gga ttt tta tct tta ata tgc tca aag aat agt ttg gag tct gat gaa 1824 Gly Phe Leu Ser Leu Ile Cys Ser Lys Asn Ser Leu Glu Ser Asp Glu 595 600 605 cct atg caa gtc cat agt aag aaa cgc cta aaa cct ctt ata cct gga 1872 Pro Met Gln Val His Ser Lys Lys Arg Leu Lys Pro Leu Ile Pro Gly 610 615 620 tta aga aag aaa ttg aaa aga tct aat cca ttc aat gaa agc cag gaa 1920 Leu Arg Lys Lys Leu Lys Arg Ser Asn Pro Phe Asn Glu Ser Gln Glu 640 630 aaa aat cga gag tcc tct gat ctg ctt cca tct cca agt gtt att act 1968 Lys Asn Arg Glu Ser Ser Asp Leu Leu Pro Ser Pro Ser Val Ile Thr 645 650 655 act caa tct gag aat att agc agc tca gca act cag gtt tct tgt gat 2016 Thr Gln Ser Glu Asn Ile Ser Ser Ser Ala Thr Gln Val Ser Cys Asp 660 665 670 cag ccc tta ctg aaa gaa gga tat aaa agt gcc caa aag cgg gcc cct 2064 Gln Pro Leu Leu Lys Glu Gly Tyr Lys Ser Ala Gln Lys Arg Ala Pro 675 680 685 caa ggg gag gca acc aca gtc tct gaa tat ttc ttc aat gat atc ttc 2112 Gln Gly Glu Ala Thr Thr Val Ser Glu Tyr Phe Phe Asn Asp Ile Phe 690 695 700 att gaa gtg g aca gaa taaaacaatc ttttctcttt ttctttttta 2163 Ile Glu Val Asp Glu Thr Glu 705 710 aattaggtct aggatttcca gagtcaatta catcaacaaa acagtattta gagcaaaata 2223 tcactgtctt atttttcttt aggttgattt tgaatactta atgagcttga tttgaagctt 2283 ttataatcag tggaaaacat ttctgaggtt cctttcattc tgactgattc agcattttgc 2343 aaatagcaag caattaagac tgctttctca gacagaaata acaactcttg tttacatttt 2403 gactcttcct gtgctaagca cacatggaca tttgggaatg ttgtggatat atgtctctgt 2463 atgaattgca gtgcagacag atttgggggt taattgtatc atatttaaca tttagcaact 2523 tcttttgtga agatttttta tttttagggg gagatgatga aggatgaagg ctttttcatt 2583 tgcttctaag tacag tcatg tatcacataa tgaagtttaa gtcaatgatg gaccacatat 2643 attacagtgg tcccatgcaa ttaaaatgga gataaattcc tatcaactag tgacattata 2703 gccatcataa cacagtgcat tgctttttta tgtttagata tgtttagata cacaaatact 2763 tactattgtg ttacaactgc ctacagtatt cagcatagta acacattgta gaggtttgta 2823 gccgaggagc aataggctat accacatagc ctcagtctgt acggtgtgta gcagcctgta 2883 ccatctcagt gtttgtaagt acactctgcg ttgtttcaca caagatcacc taacaaggca 2943 attcttagaa catgtagtta agggacacgt gactatatgt gaaaacaaat tgtcaaactt 3003 cactttagta tggcaaatgt taaagaactt ttctattatc agctgtttgt ctgactgaaa 3063 aatacatatt tttctaattc atggtgatgt aacattagtc ctaattgaaa aactagtatt 3123 taaacataat tatttataaa gatgacacat caaagggctt atttattttt aaatttttta 3183 tttaaaagga tattcagttt tagctatttt tacccctcag attgtagata aagaaggcat 3243 taaatttatg tttgtctcct ttttctgttt aattttaaag atatttaaaa tgatataact 3303 aaaaatgttt agctggtgta tatgttttga ataccttttt cccctcagtt tagtatattg 3363 actttgtact gtaaattttt ctgcttttct tggataatct caggattttc atgaggatag 3423 ggggaactca actttattta tgagacaaaa tttccataca aagctcaatc tcctttatat 3483 acccacagac ataatattag tttttaaaaa gccaatttct tcatagtttt ttcccattaa 3543 attctcaagg aacacttgga tctttaagca cggaacataa tcatgatgtt aaaaacagag 3603 aaaataaggc tttataaagt taatgattat catcagtatg aatttaaggt ttgttttaat 3663 ttcaagattt gattttttat acgtgtaatt ctattatcta cccaagcaga tctgtagtgg 3723 ttccaattag acttctcaaa cagcaaattt atcctgattt tatttgaaaa gcctcttgga 3783 ttgatagtat agtagctcag gcattggaaa ctttctgcaa actgttttgg gtttgcaggc 3843 cagatggtct ctgtggcagc tactcagctc tgcaatttca gtgtgaaaga agccatagac 3903 agtacttgaa tgaaggactg tggctggatt ggccttttag tttgaccccc tacattaggc 3963 cccaaatttt cttaccctga ggtgctgata tctgtatgga tgagttattt gtcactaaag 4023 ttatgagttg tgcctaaaag ttaactgttg actgtattat gtaatgatca gtatttcagt 4083 tgggaagata ttttagagtc tagataatta tgtttgtata ttgaaaaaat ggtggccagt 4143 ttttaagttc cttaatagaa gagaattatg tctcagcaca tataacagta atgctaattt 4203 attgaaacta ctgctgttag agcacttctt attcattgtc ttttagtgaa atttatggcg 4263 taacactttg tcagagagga ggcta tataa tttggagcgg aaattgtcta taagtaggca 4323 tttatttcat gattgatatg tcacagaaat catggtagta aatcacattg ctatttgaat 4383 accctgtttt tgtaagtttt taaaactcat attctgaaaa gatttcattc tcttagtgtt 4443 agcttgggag ttagattgcc atgattaaac tattatttat ccttgtgtaa tattagtttt 4503 taactttaac atctgtttct ttttaatcta taatgagcta gttttatgga aaatggaatt 4563 tcttactata taaagaatac agagactcat tgtattagag aatcaagtca gccagctaaa 4623 gtatcctact gttaaatcct taaacctaat tttggaaaag agaaagttaa tcaatgtatt 4683 taccttacat gttggaaaga actatgttag gtctgattca tgtgaagaag atgttgcaaa 4743 ggatttattt cacaaatttt aaaggagata tgagtaaaag tttttatctt ttcttgactt 4803 tttctcctga acacttatgt cttagcaagt ggtcaacatg aggatttgaa cgcctaattg 4863 ttggtaaatg gttgaggcat gacaaaaata ttaatatcca ctgtttacca tcatgttatt 4923 tgaaacaaaa gtgaccatgt atactatctt gcttgaagaa gtctttgaca gaaaaagcaa 4983 tatcatgtca tttataaatt ttcttgttct aaagaaagca gttatatata tatataaatt 5043 atgtaaataa aagttatttt atatc 5068 <210> 86 <211> 4484 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2522) .. (3754) <400> 86 ccggcagtcg gcggtccggg cccactgatc gtgaacaaca aacagcccca gcccccgcca 60 cctccgccgc cggcagccgc acagccacca cccggggcac cgcgggccgc cgcgggcctc 120 ctgcctgggg gcaaagcccg cgagttcaac cgcaaccagc gcaaagactc agagggctat 180 tcggagtcac cagacctgga gtttgagtat gctgacacag acaagtgggc tgcagagctc 240 tcgggtaacg cacagacctt tgtgttattt gggggtggtt ttttccttat tggtctttaa 300 taaaattaat aatgaatatc atttagggct tcattgcttt ccctagttct atcaaatata 360 tatatatata tatatatata tatatatata tatatatata tatgtataaa acatgttatt 420 tgattcaagc cttgtgtatc ttataacttt gtgttgtcct ttacttttat gaagctggct 480 agagcccagt cccattgtga gacagtgatg ttccttggct atccactgtg accctgacag 540 tgggctctcc tccagcaatg ggtcatgagg gatgcctgca tctgtgccca tctgctgctg 600 ccactgccac tctcatgtaa tgcgaggtcg gtgtgagctg cttctccagc ctctacaata 660 cacatcctgc tcaagaggta gcagccattt gagagatgca tcccaggtgg ccgtcagccc 720 tggcatggca tggtgggatg gatgcacatc ggactggaag tgtccagatg gcattctggc 780 actctggttg tctctattgt gcacatcaga gcactaagat ccccttcata attagagagc 840 ttattccagg agtcactatg actcaggggc agagttgaga gtggaagcaa atgccttgcc 900 ttctctgcac ttgtgagacc tggtgtgcaa tgcagacatg gaaccaatgg tgacgagact 960 ttgttctgac agagctttac agctacacgg aagggccaga attcctgatg aatcgaaaat 1020 gctttgagga ggacttccgg atccatgtga cagacaagaa gtggactgag ctggatacca 1080 accagcaccg gacccatgcc atgaggctcc tggatggctt ggaagtcact gccagggaga 1140 agagactcaa ggtggctcga gcaattctct atgttgctca aggcacgttt ggggagtgca 1200 gctcggaggc agaggtgcag tcctggatgc gctacaacat ctttctcctc ctggaggtgg 1260 gcacgttcaa tgctttggtg gagcttctga acatggaaat agacaacagt gccgcctgca 1320 gcagtgctgt gaggaagcct gccatctccc tggctgacag cacagacctc agggtcctgc 1380 tcaacatcat gtacctgata gtggagaccg ttcatcagga gtgtgagggt gacaaggctg 1440 agtggaggac catgcggcag accttcagag ccgagctggg ctccccgctg tacaacaatg 1500 agccatttgc catcatgctg tttgggatgg tgaccaaatt ttgcagtggt cacgcccctc 1560 actttcccat gaagaaagtt ctcttgctgc tctggaagac agtattgtgc acgctaggcg 1620 gctttgagga gctgcagagc atgaaggctg agaagcgcag catcctgggc ctccccccgc 1680 ttcctgagga cagcatc aaa gtgattcgca acatgagagc agcctctcca ccagcatctg 1740 cttcagactt gattgagcag cagcagaaac ggggccgccg agagcacaag gctctgataa 1800 agcaggacaa cctagatgcc ttcaacgagc gggatcccta caaggctgat gactctcgag 1860 aagaggaaga ggagaatgat gatgacaaca gtctggaggg ggagacgttt cccctggaac 1920 gggatgaagt gatgcctccc ccgctacagc acccacagac tgacaggctg acttgcccca 1980 aagggctccc gtgggctccc aaggtcaggc agcagcttaa gaaatagatg aacatgtgag 2040 aggatataga agtcgctttc ttgatccagg taaagcctca gttttcagtg atctgtgaag 2100 ggaatgcaaa acagatcatc agaaaatgca aggtatgctg attgtttggg ataggaaaag 2160 tgagctatat gaaaaatcag tagcttatag ctttaattgt ttaaaagttt taatatttaa 2220 gaaagtctgt tgacaaactt gttcatacta tctgaataaa gcatgttttt aagtttgata 2280 tatcccttta attttatgaa taaactagtt aacatgtatt tccaggttac tgatccagca 2340 aaattataag aaacattaaa attctctgaa aatttcagtt ttttcccttt tttcaaagag 2400 aaaaacaatt ataggagact tctcctggct tcacagtttc tggatgctgt gtttttgtta 2460 actgtaacac tttgaaatag catttgctaa aaaccttttt tctttctctc ttttttggtg 2520 a tgt ggc aga gag aaa ga c att gag atg ttc ctt gag tcc agc cgc agc 2569 Cys Gly Arg Glu Lys Asp Ile Glu Met Phe Leu Glu Ser Ser Arg Ser 1 5 10 15 aaa ttt ata ggt tac act cta ggc agt gac acg aac aca gtg gtg ggg 2617 Lys Phe Ile Gly Tyr Thr Leu Gly Ser Asp Thr Asn Thr Val Val Gly 20 25 30 ctg ccc agg cca atc cac gaa agc atc aag act ctg aaa cag cac aag 2665 Leu Pro Arg Pro Ile His Glu Ser Ile Lys Thr Leu Lys Gln His Lys 35 40 45 tac acg tcg att gca gag gtc cag gca cag atg gag gag gaa tac ctc 2713 Tyr Thr Ser Ile Ala Glu Val Gln Ala Gln Met Glu Glu Glu Tyr Leu 50 55 60 cgc tcc cct ctc tca ggg gga gaagaa gtt gag caa gtc cct gca 2761 Arg Ser Pro Leu Ser Gly Gly Glu Glu Glu Val Glu Gln Val Pro Ala 65 70 75 80 gaa acc ctc tac caa ggc ttg ctc ccc agc ctg cct cag tat atg att 2809 Glu Thr Leu Tyr Gln Gly Leu Leu Pro Ser Leu Pro Gln Tyr Met Ile 85 90 95 gcc ctc ctg aag atc ctg ttg gct gca gca ccc acc tca aaa gcc aaa 2857 Ala Leu Leu Lys Ile Leu Leu Ala Ala Ala Pro Thr Ser Lys Ala Lys 100 105 110 aca gac tca atc aac atc cta gcg gac gtc ttg cct gag gag atg ccc 2905 Thr Asp Ser Ile Asn Ile Leu Ala Asp Val Leu Pro Glu Glu Met Pro 115 120 125 acc aca gtg ttg cag agc atg aag ctg ggg gtg gat gta aac cgc cac Thr 53 Val Leu Gln Ser Met Lys Leu Gly Val Asp Val Asn Arg His 130 135 140 aaa gag gtc att gtt aag gcc att tct gct gtc ctg ctg ctg ctg ctc 3001 Lys Glu Val Ile Val Lys Ala Ile Ser Ala Val Leu Leu Leu Leu Leu 145 150 155 160 aag cac ttt aag ttg aac cat gtc tac cag ttt gaa tac atg gcc cag 3049 Lys His Phe Lys Leu Asn His Val Tyr Gln Phe Glu Tyr Met Ala Gln 165 170 175 cac ctg gtg ttt gcc aac tgc att cct atc cta aag ttc ttc aat 3097 His Leu Val Phe Ala Asn Cys Ile Pro Leu Ile Leu Lys Phe Phe Asn 180 185 190 caa aac atc atg tcc tac atc act gcc aag aac agc att tct gtc ctg 3145 Gln Asn Ile Met Ser Tyr Ile Thr Ala Lys Asn Ser Ile Ser Val Leu 195 200 205 gat tac cct cac tgc gtg gtg cat gag ctg cca gag ctg acg gcg gag 3193 Asp Tyr Pro His Cys Val Val His Glu Leu Pro Glu Leu Thr Ala Glu 210 215 220 a gt ttg gaa gca ggt gac agt aac caa ttt tgc tgg agg aac ctc ttt 3241 Ser Leu Glu Ala Gly Asp Ser Asn Gln Phe Cys Trp Arg Asn Leu Phe 225 230 235 240 tct tgt atc aat ctg ctt cgg atc ttg aac ag aag tgg aag 3289 Ser Cys Ile Asn Leu Leu Arg Ile Leu Asn Lys Leu Thr Lys Trp Lys 245 250 255 cat tca agg aca atg atg ctg gtg gtg ttc aag tca gcc ccc atc ttg 3337 His Ser Arg Thr Met Met Leu Val Phe Lys Ser Ala Pro Ile Leu 260 265 270 aag cgg gcc cta aag gtg aaa caa gcc atg atg cag ctc tat gtg ctg 3385 Lys Arg Ala Leu Lys Val Lys Gln Ala Met Met Gln Leu Tyr Val Leu 275 280 285 aag ctgta cc cag acc aaa tac ttg ggg cgg cag tgg cga aag 3433 Lys Leu Leu Lys Val Gln Thr Lys Tyr Leu Gly Arg Gln Trp Arg Lys 290 295 300 agc aac atg aag acc atg tct gcc atc tac cag aag gtg cgg cat cgg 3481 Ser Asn Met Lys Thr Met Ser Ala Ile Tyr Gln Lys Val Arg His Arg 305 310 315 320 ctg aac gac gac tgg gca tac ggc aat gat ctt gat gcc cgg cct tgg 3529 Leu Asn Asp Asp Trp Ala Tyr Gly Asn Asp Leu Asp Ala Arg Pro Trp 325 330 335 gac ttc cag gca gag gag tgt gcc ctt cgt gcc aac att gaa cgc ttc 3577 Asp Phe Gln Ala Glu Glu Cys Ala Leu Arg Ala Asn Ile Glu Arg Phe 340 345 350 350 aac gcc cgg cgc tat g cac agc aac cct gac ttc ctg cca 3625 Asn Ala Arg Arg Tyr Asp Arg Ala His Ser Asn Pro Asp Phe Leu Pro 355 360 365 gtg gac aac tgc ctg cag agt gtc ctg ggc caa cgg gtg gac ctc cctn Cyp Asp Gln Ser Val Leu Gly Gln Arg Val Asp Leu Pro 370 375 380 gag gac ttt cag atg aac tat gac ctc tgg tta gaa agg gag gtc ttc 3721 Glu Asp Phe Gln Met Asn Tyr Asp Leu Trp Leu Glu Arg Glu Val Phe 385 390 400 tcc aag ccc att tcc tgg gaa gag ctg ctg cag tgaggctgtt ggttagggga 3774 Ser Lys Pro Ile Ser Trp Glu Glu Leu Leu Gln 405 410 ctgaaatgga gagaaaagat gatctgaagg tacctgtggg actgtcctag ttcattgctg 3834 cagtgctccc atcccccacc aggtggcagc acagccccac tgtgtcttcc gcagtctgtc 3894 ctgggcttgg gtgagcccag cttgacctcc ccttggttcc cagggtcctg ctccgaagca 3954 gtcatctctg cctgagatcc attcttcctt tacttccccc accctcctct c ttggatatg 4014 gttggttttg gctcatttca caatcagccc aaggctggga aagctggaat gggatgggaa 4074 cccctccgcc gtgcatctga atttcagggg tcatgctgat gcctctcgag acatacaaat 4134 ccttgctttg tcagcttgca aaggaggaga gtttaggatt agggccaggg ccagaaagtc 4194 ggtatcttgg ttgtgctctg gggtgggggt ggggtgtttc tgatgttatt ccagcctcct 4254 gctacattat atccagaagt aattgcggag gctccttcag ctgcctcagc actttgattt 4314 tggacaggga caaggtagga agagaagctt cccttaacca gaggggccat ttttcctttt 4374 ggctttcgag ggcctgtaaa tatctatata taattctgtg tgtattctgt gtcatgttgg 4434 ggtttttaat gtgattgtgt attctgttta cattaaaaag aagcaaaaat 4484 <210> 87 <211> 4292 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (272) .. (1435) <400> 87 ctcgctttct tctaggcgcg tttcctgaag gtcgatggcc aggtggtctt cataaactat 60 actgccttgt gatgcctccc tagaaatgag aggtctcaat accagctcag accatgtgga 120 ccgcggatga gattgctcag ctatgctatg aacactatgg gatcaggctg cccaagaagg 180 ggaagcctga gccaaaccat gagtggacat tattggcagc ggtggtgaag atacaatctc 240 cagctgacaa ggcctgcgac acccctgata a gcc ggt gca agt gac aaa gga 292 Ala Gly Ala Ser Asp Lys Gly 1 5 agt tgt gtc aat ggg aac agg aac aaa atg cat agg aca gtc caa aat 340 Ser Cys Val Asn Gly Asn Arg Asn Lys Met His Arg Thr Val Gln Asn 10 15 20 gag gaa gaa cgg tac ctt ctc cac caa ctc cag ttg gca gcc acc ctg 388 Glu Glu Glu Arg Tyr Leu Leu His Gln Leu Gln Leu Ala Ala Thr Leu 25 30 35 aaa gag gat agc atc ttt gtc cca gga act caa aaa gga gtg tgg aaa 436 Lys Glu Asp Ser Ile Phe Val Pro Gly Thr Gln Lys Gly Val Trp Lys 40 45 50 55 ctt aga cga gac ctc att ttt gtg ttt ttc tcc agc cat aca ccc tgt 484 Leu Arg Arg Asp Leu Ile Phe Val Phe Phe Ser Ser His Thr Pro Cys 60 65 70 ggg gat gcc tcc atc att ccg atg ctt gag ttt ga a gat cag cct tgc 532 Gly Asp Ala Ser Ile Ile Pro Met Leu Glu Phe Glu Asp Gln Pro Cys 75 80 85 tgt cct gtc ttc aga aat tgg gcc aac aac tca tca gta gaa gcc agt 580 Cys Pro Val Phe Arg Asn Trp Ala Asn Asn Ser Ser Val Glu Ala Ser 90 95 100 agt aac ctg gaa gct cct gga aat gaa aga aaa tgt gaa gac cct gac 628 Ser Asn Leu Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp 105 110 115 agt cct gta acc aaa aag atg agg ctt gag cct ggg aat gca gcc agg 676 Ser Pro Val Thr Lys Lys Met Arg Leu Glu Pro Gly Asn Ala Ala Arg 120 125 130 135 gag gtc acc aac gga gca gct cac cat cag agt ttt ggc aag cag aaa 724 Glu Val Thr Asn Gly Ala Ala His His Gln Ser Phe Gly Lys Gln Lys 140 145 150 agt ggc cca atc tca cca ggc atc cac agc tgt gat ctc act gta gag 772 Ser Gly Pro Ile Ser Pro Gly Ile His Ser Cys Asp Leu Thr Val Glu 155 160 165 gga ctg gct act gtc acc aga ata gcc cct ggt agt gcc aaa gtg ata 820 Gly Leu Ala Thr Val Thr Arg Ile Ala Pro Gly Ser Ala Lys Val Ile 170 175 180 gac gtt tat aga act gga gcc aag tgt g ta cct gga gaa gct gga gac 868 Asp Val Tyr Arg Thr Gly Ala Lys Cys Val Pro Gly Glu Ala Gly Asp 185 190 195 tcc gga aag ccg ggt gct gcg ttt cac cag gtg ggg ctg ctc cga gtg 916 Ser Gly Lys Pro Gly Ala Phe His Gln Val Gly Leu Leu Arg Val 200 205 210 215 aag cca ggc cgt gga gac aga aca cgc tcc atg tcc tgt agt gac aag 964 Lys Pro Gly Arg Gly Asp Arg Thr Arg Ser Met Ser Cys Ser Asp Lys 220 225 230 atg gcc cga tgg aac gtc ctc gga tgc caa ggg gca ctg ttg atg cac 1012 Met Ala Arg Trp Asn Val Leu Gly Cys Gln Gly Ala Leu Leu Met His 235 240 245 ttg ctg gaa gag ccc atc tc ctg tca gc aag tgc 1060 Leu Leu Glu Glu Pro Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys 250 255 260 cca tac agc cag gaa gcc atg cag aga gca ctg att gga agg tgt cag 1108 Pro Tyr Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly Arg Cys Gln 265 270 275 aat gtg tct gct tta cca aaa ggc ttc gga gtt caa gaa tta aaa ata 1156 Asn Val Ser Ala Leu Pro Lys Gly Phe Gly Val Gln Glu Leu Lys Ile 280 285 290 290 295 ctg cag tg tta cta ttt gaa cag agc cgc agt gcg gtg cag gca 1204 Leu Gln Ser Asp Leu Leu Phe Glu Gln Ser Arg Ser Ala Val Gln Ala 300 305 310 aaa agg gct gat agc cca ggt cga ctt gtt cct tgt ggg gca gcc atc 125 Arg Ala Asp Ser Pro Gly Arg Leu Val Pro Cys Gly Ala Ala Ile 315 320 325 agc tgg agt gca gtt cct gag cag cct ttg gat gtt act gcc aat ggc 1300 Ser Trp Ser Ala Val Pro Glu Gln Pro Leu Asp Val Thr Ala Asn Gly 330 335 340 ttt cca cag gga aca aca aag aaa aca att gga agc ctt cag gca aga 1348 Phe Pro Gln Gly Thr Thr Lys Lys Thr Ile Gly Ser Leu Gln Ala Arg 345 350 355 tcc caa atc agc aaa gtg gaa ctc ttc tca ttc cag aag ctg cta 1396 Ser Gln Ile Ser Lys Val Glu Leu Phe Arg Ser Phe Gln Lys Leu Leu 360 365 370 375 agc aga att gca agg gac aag tgg cca cac tcc ctc agg tgatgctgtt 1445 Ser Arg Ile Ala Arp Asg Pro His Ser Leu Arg 380 385 gacctatgtt ttctcatatt taggtagaca actgttttga ttctggcttc tgagtagcaa 1505 gaagctttgg caggagtggt ggttcagcaa gccagtggca cttattgttg accacaagtt 1565 cttctttccc catag cccta tttgcagata cgtgcatgat ctgagatgca gaggatgggt 1625 agtttggtgg tatagagtta taaaaaacta aggatagaac tggggcttgg ccattccagg 1685 ccctcctttg attccacctc tagatggaga tcactgtgga aatgggagtg ctctaagagc 1745 aatatattct gttacaagtg ttactcctct tttccttttg aacttgcagc tccatgactt 1805 aaattgctct tcaaacaaaa attcaaagaa ctttaaaacc actcttggga acaggtagat 1865 gggtgcagtg acattctgac agtgaccacc tagatttagg tgaagtttca caggtgaagg 1925 acacagttcc cactaaactg tcttcatttc aaacaactac cacaagttaa ggaaagcccc 1985 aaaccaccca tacttctgac caactggcta caaatttgag tgtctccact ccccttcacg 2045 ttcagtcatt cactagaaca tctctcagaa ctcagaaaag cactatagtt gccattaaag 2105 ttttattatg aaggctacag atcagtacta gccaaaagga gagagatata gggtaagata 2165 tgggagggtc gcaaaggcag agcttccatg tcctcaggac atatcacctt cccagcacat 2225 tgctgcgcat caccaactag gaatctcact cagacatcag tgtccaaagt ttttgttgga 2285 gtttcattaa ctattatgac tgattgaatt attggccaca tgatgtgatt gaacttaatc 2345 tccaacctcc tcctctccca agagttcaaa ctgatatcac gtgtctcaga gccctaattc 2405 tctacatggt tggtctttct ggcatggccg gtatcatcct gaaactatct cgggggccca 2465 ccatgagtca cctggttaaa cagaaactca cgtgtgatca gcgagatcta ccatgcagga 2525 caaagacact tgcagaaact ccaaagctta gaggctccca ggaactggtg acaaagacca 2585 agtgaatcct tcattatatg acagtgggga aactaaggag tagctagaaa cttctatatg 2645 aagaggcatc gccatcatgc atactgaagt gatggatctg tggtcagttg gcttctttct 2705 tgggtttcca tatattctat atgtcaaatc tgaatttagg tgaggagata cttctaaggc 2765 agagttttgc tcctgttaac caggctggag tgcagtggca caatttcagc tcactgcagc 2825 ctccgcctcc caggttcaag tgattttcct gcctcagtct ccagagtagc taggattgca 2885 ggcacccgcc accacgcccg gctaattttt ggtatatttg gtagggacgg ggtttcacca 2945 tattgaccag gctggtcttg aactactgac ctcaggcgat ccacctgcct cagcctccca 3005 aagtgccagg attacaggcg tgagccaccg cctggcatgg tgcagaagct ggatacctac 3065 caggagtaca aggaggctgc gtcctcttac caggaagcct ggagcacact ccggaagcag 3125 gtgtttggat cctggatcag aaacccaccg gattatcacc agttcaagtg agaaggaaat 3185 gtttgctctg gtagcaggac ccttcatcct gaactgcctt cctccacgca ggacaagtct 3245 tagctttttt ggtagttaaa tcagg gaaca ttctttctga gctttgcatc tctgttgtgt 3305 aatacagatg gaatctggaa cttagagcaa gctatacttg attgaagtag ctctctgcta 3365 aaatggcatc tcactaatga cctcactatc tgacttccat tgtgttttat tgcttctcta 3425 aaatatgaaa tcagagtttg gaacatgatg ctttgaaagt actctgcagc agctctgttt 3485 tatgggttcc tacattgatt cagcaaatat ttattgagct gaaatgatgt ttgacgctct 3545 gcaagtttta cagctttgcc tagcatagcg aacatatatt ttgtattccc agcctttctt 3605 tcttcaggga gccattcttt tcccattctt cagtgatcct gctctgtgcc tcagacttgg 3665 ctgaaggtaa ccttactccc tggctctagg aatagcctgt gagccagccc tggactgccc 3725 tggacttgtt ctcagaggta tcaggaaagg ctttctgttt tgatctggag ctgtaagggt 3785 cacataatca tgggactgcc ggtggccatc ttttcctact acctagagaa agccagcaaa 3845 gaatgaaggc aacaaaggaa acagccaaga gaatcaaaga tctagtaaca ctgtttagat 3905 gtctcaatta tgtgagacag attcctgttg ttattttgat taagcctgtt tgtgttggtt 3965 ttctgactta caattgaaag agttctgtcc aaaaagccaa aaggtggcca ggcttggtgg 4025 ctcaggcctg taatcccagc actttgggaa gcccaggcag gcagatcact tgaggtcagg 4085 agttcaagac cagcctggcc aacctggtga aaccctgtct ctactaaaag tgcaaaaact 4145 agccgggcat ggtggcgcac acctgtaatc ctagctactc gggaggctga ggcaggagaa 4205 ttgcttgaac ccaggaggcg gaggtagtgg tgagcaaaga tcgtaccgct gcactccagc4ag ccagcc 4265 <210> 88 <211> 2593 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (198) .. (1250) <400> 88 gtttatttgt gcgagcagtt ggagatgggg ttcttcgatg ttgggatttg ttatattgtg 60 gaggcttatc atccaaccag tatatttatg gaacatgtac tgagtcagga gctttatctt 120 cagtgttaga aataaaatga ttcattgcat gctctatgtt tgggaatgtt agtaaactgt 180 gtttttctcc cctttaa tta gta act gaa att agg agc tca tgg aga aaa 230 Leu Val Thr Glu Ile Arg Ser Ser Trp Arg Lys 1 5 10 gct att gaa atg gaa gaa aac aga act aaa gaa cca att caa atg gat 278 Ala Ile Glu Met Glu Glu Asn Arg Thr Lys Glu Pro Ile Gln Met Asp 15 20 25 gct gaa cat aga gaa gta ttg cca gaa tca cct gtg ttg cac aat 326 Ala Glu His Arg Glu Val Leu Pro Glu Ser Leu Pro Val Leu His Asn 30 35 40 caa aga gaa ttt agc atg gct gat ttt ctc tta gaa acc act gta tca 374 Gln Arg Glu Phe Ser Met Ala Asp Phe Leu Leu Glu Thr Thr Val Ser 45 50 55 gat ttt ggc cag tct cat ttg act gaa gag aaa gtt att tca gat tgc 422 Asp Phe Gly Gln Ser His Leu Thr Glu Glu Lys Val Ile Ser Asp Cys 60 65 70 75 gag tgt gtg cct cag aaa cat gtg ctg acc agt cac ata gat gaa cca 470 Glu Cys Val Pro Gln Lys His V al Leu Thr Ser His Ile Asp Glu Pro 80 85 90 cca aca caa aat cag tca gat ttg tta aat aag aaa gta att tgc aag 518 Pro Thr Gln Asn Gln Ser Asp Leu Leu Asn Lys Lys Val Ile Cys Lys 95 100 105 caa gat ttg gaa tgt tta gcc ttc acc aag ctt tca gaa act agc cga 566 Gln Asp Leu Glu Cys Leu Ala Phe Thr Lys Leu Ser Glu Thr Ser Arg 110 115 120 atg gag aca ttc tcc cct gct gtc ggc aat agg ata gat ggt atg 614 Met Glu Thr Phe Ser Pro Ala Val Gly Asn Arg Ile Asp Val Met Gly 125 130 135 ggc agt gaa gag gag ttt atg aaa ata ttg gac cac tta gaa gtt tct 662 Gly Ser Glu Glu Glu Phe Met Lys Ile Leu Asp His Leu Glu Val Ser 140 145 150 155 tgt aac aaa cct tcc aca aat aaa act atg ttg tgg aat tct ttt cag 710 Cys Asn Lys Pro Ser Thr Asn Lys Thr Met Leu Trp Asn Ser Phe Gln 160 165 170 ata tca agt gga att agt tct aag agt ttt aaa gat aat gat ttt ggc 758 Ile Ser Ser Gly Ile Ser Ser Lys Ser Phe Lys Asp Asn Asp Phe Gly 175 180 185 ata tta cac gaa act ctc ccg gaa gaa gtt ggt cat cta agt ttt aat 806 Ile Leu His Glu Thr L eu Pro Glu Glu Val Gly His Leu Ser Phe Asn 190 195 200 agt tcc agt agt tca gag gcc aat ttt aaa ctg gag cca aat agt cct 854 Ser Ser Ser Ser Ser Glu Ala Asn Phe Lys Leu Glu Pro Asn Ser Pro 205 210 215 atg cat ggt ggc act ctt cta gaa gat gtt gtg gga ggg aga cag act 902 Met His Gly Gly Thr Leu Leu Glu Asp Val Val Gly Gly Arg Gln Thr 220 225 230 235 act cca gaa tca gac ttt aat tta cag gct ctt cgc agt aga tac gag 950 Thr Pro Glu Ser Asp Phe Asn Leu Gln Ala Leu Arg Ser Arg Tyr Glu 240 245 250 gct ctg aag aaa tct ctt tcc aag aaa agg gaa gaa tct tac ctc tcg 998 Ala Leu Lys Lys Ser Leu Ser Lys Lys Arg Glu Glu Ser Tyr Leu Ser 255 260 265 aat tcc caa aca ccc gaa aga cac aaa cca gaa ttg agc cct act ccc 1046 Asn Ser Gln Thr Pro Glu Arg His Lys Pro Glu Leu Ser Pro Thr Pro 270 275 275 caa aat gta caa aca gat gat acg ctt aac ttt ttg gac acc tgt gat 1094 Gln Asn Val Gln Thr Asp Asp Thr Leu Asn Phe Leu Asp Thr Cys Asp 285 290 295 ttg cat act gag cat ata aag cca tct tta cgc acg tcc atc ggt gaa 1142 Leu H is Thr Glu His Ile Lys Pro Ser Leu Arg Thr Ser Ile Gly Glu 300 305 310 315 aga aaa cgg tct ctt tca cca cta att aag ttt tct cca gtg gaa caa 1190 Arg Lys Arg Ser Leu Ser Pro Leu Ile Lys Phe Ser Pro Val Glu Gln 320 325 330 aga ttg aga acc aca ata gca tgt agt ctt gga gaa cta cct aat tta 1238 Arg Leu Arg Thr Thr Ile Ala Cys Ser Leu Gly Glu Leu Pro Asn Leu 335 340 345 345 aag ggt aag gtt taaatagacc tatgcatatt cgtt gtt Lys Gly Lys Val 350 caacttttga taaaaccagt acacaaagaa tgctgcatga cctttattgt taatgtgctc 1350 ccccttcctt catttaggat gaggggaatg atccctcact ggacaggtcc tttcagaatc 1410 tctgtttatg tatatatagt tacaattgat ttgagacagg ggtgggaaaa aaaagccccc 1470 ccaatctgaa gcttacaggt tttataatac aaatgactga aaagtaaatg tcatcaaaat 1530 cttgcccagt ggaaggtggt ttttaaacac ttgagaaacc caattttaaa tatcatcact 1590 ataatggtgt aatatctggg ggtggggtgt agaaataaaa gaagccaggt cagtgtatta 1650 gtttcctagg gctgccataa caaagcacca tcaagtgggt ggcttagaac agcagaaatt 1710 tattgtctct ggagacagta agttctagag gctagatgtc caaaatcaa g gtgttgacag 1770 ggccatgttc cctctgaagc cactagaaga ggatccttct ttgcctcttc tagcctctgg 1830 tagcaccagg cattccttgg cttgtggcag tgtaattcta atctttgcct ccattgtcac 1890 atggtattct tcccttgtgt gtgtattgtc ttataaggac acagtcatat tagctaatta 1950 atgggtcacc ctactccagt atgacctcat cttacttagc taattatatc tgtaatgacc 2010 acatttccaa ataaggtcac attctgaggt actggggtta gaacttcaac atatgttttt 2070 gggggtattc agttcataac agttagtatt aataattatt gaagctaggt gatggatata 2130 ttgagttaat cacagttctc ttcacttttg tatgtttgaa tgttttcctc ataaaaggtt 2190 aaaaaaattg ctcttgtagc tcattaagag agataaggat ctggtgatac agattcatta 2250 catactctga tttgcccata atagttatac actgccatat tgaaaagtat ttggctgggc 2310 acagtggctc acacctgcaa tcccagcact ttgggagtcc gagatgggag gatcacttga 2370 acccaggagt tcgagactag cctcagcaac acagggagac tatgtctcta caaaaaatta 2430 aacaattagc tgggcacgtt ggcgcatgcc tgtgatccca ggtacatagg aggctgaggt 2490 gggaggattg cttgggcctg ggagtttgag gctgaagtga gctgcgatcg tgccactgca 2550 ctccagcctg ggtgacagag caagaccctg tcgcagaaaa aag 2593 <210> 89 <211> 3800 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (587) <400> 89 ag gag ttc gac ctg ccc ccg gcc gcg atg ccc aac acg gag aac gtg 47 Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val 1 5 10 15 tac tcg cag tgg ctc gcc ggc tac gcg gcc tcc agg cag ctc aaa gat 95 Tyr Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp 20 25 30 ccc ttc ctt agc ttc gga gac tcc aga caa tcg cct ttt gcc tcc tcg 143 Pro Phe Leu Ser Phe Gly Ser Arg Gln Ser Pro Phe Ala Ser Ser 35 40 45 tcg gag cac tcc tcg gag aac ggg agc ttg cgc ttc tcc aca ccg ccc 191 Ser Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro 50 55 60 ggg gag ctg gac gga ggg atc tcg ggg cgc agc ggc acg gga agt gga 239 Gly Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly 65 70 75 ggg agc acg ccc cat att agt ggt ccg ggc ccg agg ccc 287 Gly Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser 80 85 90 95 aaa gag ggc aga cgc agc gac act tgt gag tac tgt ggg aaa gtc ttc 335 Lys Glu Gly Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe 100 105 110 aag aac tgt agc aat ctc act gtc cac agg aga agc cac acg ggc gaa 383 Lys Asn Cys Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu 115 120 125 agg cct tat aaa tgc gag ctg tgc aac tat gcc tgt gcc cagt agc 431 Arg Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser 130 135 140 aag ctc acc agg cac atg aaa acg cat ggc cag gtg ggg aag gac gtt 479 Lys Leu Thr Arg His Met Lys Thr His Gly Gln Val Gly Lys Asp Val 145 150 155 tac aaa tgt gaa att tgt aag atg cct ttt agc gtg tac agt acc ctg 527 Tyr Lys Cys Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Thr Leu 160 165 170 175 gag aaa cac atg aaa aaa tgg cac agt gat cga gtg ttg aat aat gat 575 Glu Lys His Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp 180 185 190 ata aaa act gaa tagaggtata ttaatacccc tccctcactc ccacctgaca 627 Ile Lys Thr Glu 195 cccccttttt caccactccc cttccccatc gccctccagc cccactccct gtaggatttt 687 tttctagtcc catgtgattt aaacaaacaa acaaacaaac agaagtaacg aagctaagaa 747 tatgagagtg cttgtcacca gcacacctgt tttttttctt tttctttttc ttttttcttt 807 ttcctttttt tttttttcct ttatgttctc accgtttgaa tgcatgatct gtatggggca 867 atactattgc attttacgca aactttgagc ctttctcttg tgcaataatt tacatgttgt 927 gtatgttttt ttttaaactt agacagcatg tatggtatgt tatggctatt ttaaattgtc 987 cctaattcgt tgctgagcaa acatgttgct gtttccagtt ccgttctgag agaaaaagag 1047 agagagagag aaaaagacca tgctgcatac attctgtaat acatatcatg tacagtttta 1107 ttttataacg tgaggaggaa aaacagtctt tggattaacc ctctatagac agaatagata 1167 gcactgaaaa aaaatctcta tgagctaaat gtctgtctct aaagggttaa atgtatcaat 1227 tggaaaggaa gaaaaaaggc cttgaattga caaattaaca gaaaaacaga acaagtttat 1287 tctatcattt ggttttaaaa tatgagtgcc ttggatctat taaaaccaca tcgatggttc 1347 tttctacttg ttataaactt gtagcttaat tcagcattgg gtgaggtaat aaaccttagg 1407 aactagcata taattctata ttgtatttct cacaacaatg gctacctaaa aagatgaccc 1467 attatgtcct agttaatcat catttttcct ttagtttaat tttataaaca aaactgatta 1527 taccagtata aaagctactt tgctcctggt gagagcttaa aagaaatggg ctgttttgcc 1587 caaagtttta ttttttttaa acaatgatta aattgaatgt gtaatgtgca aaagccctg g 1647 aacgcaatta aatacactag taaggagttc attttatgaa gatatttgct ttaataatgt 1707 ctttttaaaa atactggcac caaaagaaat agatccagat ctacttggtt gtcaagtgga 1767 caatcaaatg ataaacttta agaccttgta taccatattg aaaggaagag gctgacaata 1827 aggtttgaca gaggggaaca gaagaaaata atatgattta ttagcacaac gtggtactat 1887 ttgccattta aaactagaac aggtatataa gctaatattg atacaatgat gattaactat 1947 gaattcttaa gacttgcatt taaatgtgac attcttaaaa aaagaagaga aagaatttta 2007 agagtagcag tatatatgtc tgtgctccct aaaagttgta cttcatttct tttccataca 2067 ctgtgtgcta tttgtgttaa catggaagag gattcattgt ttttattttt atttttttaa 2127 ttttttcttt tttattaagc tagcatctgc cccagttggt gttcaaatag cacttgactc 2187 tgcctgtgat atctgtatct tttctctaat cagagataca gaggttgagt ataaaataaa 2247 cctgctcaga taggacaatt aagtgcactg tacaattttc ccagtttaca ggtctatact 2307 taagggaaaa gttgcaagaa tgctgaaaaa aaattgaaca caatctcatt gaggagcatt 2367 ttttaaaaac taaaaaaaaa aaaactttgc cagccattta cttgactatt gagcttactt 2427 acttggacgc aacattgcaa gcgctgtgaa tggaaacaga atacacttaa catagaaatg 2487 aatgattgct ttcgcttcta cagtgcaagg atttttttgt acaaaacttt tttaaatata 2547 aatgttaaga aaaatttttt ttaaaaaaca cttcattatg tttagggggg aactgcattt 2607 tagggttcca ttgtcttggt ggtgttacaa gacttgttat ccatttaaaa atggtagtgg 2667 aaattctatg ccttggatac acaccgctct tcaggttgta aaaaaaaaaa aaacatacat 2727 tggggaaagg tttaagatta tatagtactt aaatatagga aaatgcacac tcatgttgat 2787 tcctatgcta aaatacattt atggtctttt ttctgtattt ctagaatggt atttgaatta 2847 aatgttcatc tagtgttagg cactatagta tttatattga agcttgtatt tttaactgtt 2907 gcttgttctc ttaaaaggta tcaatgtacc ttttttggta gtggaaaaaa aaaagacagg 2967 ctgccacagt atattttttt aatttggcag gataatatag tgcaaattat ttgtatgctt 3027 caaaaaaaaa aaaaagagag aaacaaaaaa gtgtgacatt acagatgaga agccatataa 3087 tggcggtttg ggggagcctg ctagaatgtc acatggatgg ctgtcatagg ggttgtacat 3147 atcctttttt gttccttttt cctgctgcca tactgtatgc agtactgcaa gctaataacg 3207 ttggtttgtt atgtagtgtg ctttttgtcc ctttccttct atcaccctac attccagcat 3267 cttaccttca tatgcagtaa aagaaagaaa gaaaaaaaaa ggaaaaaaaa aaaaaaacca 3327 atgt tttgca gtttttttca ttgccaaaaa ctaaatggtg ctttatattt agattggaaa 3387 gaatttcata tgcaaagcat attaaagaga aagcccgctt tagtcaatac ttttttgtaa 3447 atggcaatgc agaatatttt gttattggcc ttttctattc ctgtaatgaa agctgtttgt 3507 cgtaacttga aattttatct tttactatgg gagtcactat ttattattgc ttatgtgccc 3567 tgttcaaaac agaggcactt aatttgatct tttatttttc tttgttttta tttttttttt 3627 tatttagatg accaaaggtc attacaacct ggctttttat tgtatttgtt tctggtcttt 3687 gttaagttct attggaaaaa ccactgtctg tgtttttttg gcagttgtct gcattaacct 3747 gttcatacac ccattttgtc cctttattga aaaaataaaa aaaattaaag tac 3800 <210> 90 <211> 3824 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (3051) <400> 90 ctg gat gag aaa gag gag aca gaa tat gag tac agc ggc agc gag gag 48 Leu Asp Glu Lys Glu Glu Thr Glu Tyr Glu Tyr Ser Gly Ser Glu Glu 1 5 10 15 gaa gat gac agc cat gga gag gaa gga gag cca agc tcc atc atg aac 96 Glu Asp Asp Ser His Gly Glu Glu Gly Glu Pro Ser Ser Ile Met Asn 20 25 30 gtg cct gga gag tcg act cta cgc cgg gag ttt ctc cgg ctc cag cag 144 Val Pro Gly Glu Ser Thr Leu Arg Arg Glu Phe Leu Arg Leu Gln Gln 35 40 45 gaa aat aag agc aac tca gag gct tta aaa cag cag cag cag ctg cag 192 Glu Asn Lys Ser Asn Ser Glu Ala Leu Lys Gln Gln Gln Gln Leu Gln 50 55 60 cag cag cag cag cga gac ccc gag gca cac atc aaa cac ctg ctg cac 240 Gln Gln Gln Gln Arg Asp Pro Glu Ala His Ile Lys His Leu Leu His 65 70 75 80 cag cgg cag cgg cgc ata gag gag cag aag gag gag cgg cgc cgc gtg 288 Gln Arg Gln Arg Arg Ile Glu Glu Gln Lys Glu Glu Arg Arg Arg Val 85 90 95 gag gag caa cag cgg cgg gag cgg gag cag cgg aag ctg cag gag aag 336 Glu Glu Gln Gln Arg Arg Glu Arg Glu Gln Lys Leu Gln Glu Lys 100 105 110 gag cag cag cgg cgg ctg gag gac atg cag gct ctg cgg cgg gag gag 384 Glu Gln Gln Arg Arg Leu Glu Asp Met Gln Ala Leu Arg Arg Glu Glu 115 120 125 gag cgg cgg cag gcg gag cgt gag cag cat gat tat att agg cta 432 Glu Arg Arg Gln Ala Glu Arg Glu Gln Glu Tyr Ile Arg His Arg Leu 130 135 140 gag gag gag cag cga cag ctc gag atc ctt cag caa cag ctg ctc cag 480 Glu Glu Glu Gln Arg Gln Leu Glu Leu Glu Gln Gln Leu Leu Gln 145 150 155 160 gaa cag gcc ctg ctg ctg gaa tac aag cgg aag cag ctg gag gag cag 528 Glu Gln Ala Leu Leu Leu Glu Tyr Lys Arg Lys Gln Leu Glu Glu Gln 165 170 175 cgg cag ctc cag agg cag ctg cag cag gag cat gcc tac 576 Arg Gln Ser Glu Arg Leu Gln Arg Gln Leu Gln Gln Glu His Ala Tyr 180 185 190 ctc aag tcc ctg cag cag cag caa cag cag cag cag ctt cag aaa cag 624 Leu Ser Leu Gln Gln Gln Gln Gln Gln Gln Gln Leu Gln Lys Gln 195 200 205 cag cag cag cag ctc ctg cct ggg gac agg aag ccc ctg tac cat tat 672 Gln Gln Gln Gln Leu Leu Pro Gly Asp Arg Lys Pro Leu Tyr His Ty r 210 215 220 ggt cgg ggc atg aat ccc gct gac aaa cca gcc tgg gcc cga gag gta 720 Gly Arg Gly Met Asn Pro Ala Asp Lys Pro Ala Trp Ala Arg Glu Val 225 230 235 240 gaa gag aga aca agg atg aac aag cag cag aac tct ccc ttg gcc aag 768 Glu Glu Arg Thr Arg Met Asn Lys Gln Gln Asn Ser Pro Leu Ala Lys 245 250 255 agc aag cca ggc agc acg ggg cct gag ccc ccc atc ccc cag gcc tcc 816 Ser Lys Pro Gly Ser Thr Gly Pro Glu Pro Pro Ile Pro Gln Ala Ser 260 265 270 cca ggg ccc cca gga ccc ctt tcc cag act cct cct atg cag agg ccg 864 Pro Gly Pro Pro Gly Pro Leu Ser Gln Thr Pro Pro Met Gln Arg Pro 275 280 285 gtg gag ccc cag gag gga ccg cac aag agc ctg gtg gca cac cgg gtc 912 Val Glu Pro Gln Glu Gly Pro His Lys Ser Leu Val Ala His Arg Val 290 295 300 cca ctg aag cca tat gca gca cct gta ccc cga tcc cag tccg cag 960 Pro Leu Lys Pro Tyr Ala Ala Pro Val Pro Arg Ser Gln Ser Leu Gln 305 310 315 320 gac cag ccc acc cga aac ctg gct gcc ttc cca gcc tcc cat gac ccc 1008 Asp Gln Pro Thr Arg Asn Leu Ala Ala Phe Pro A la Ser His Asp Pro 325 330 335 gac cct gcc atc ccc gca ccc act gcc acg ccc agt gcc cga gga gct 1056 Asp Pro Ala Ile Pro Ala Pro Thr Ala Thr Pro Ser Ala Arg Gly Ala 340 345 350 gtc atc cgc cag aat tca gac ccc acc tct gaa gga cct ggc ccc agc 1104 Val Ile Arg Gln Asn Ser Asp Pro Thr Ser Glu Gly Pro Gly Pro Ser 355 360 365 ccg aat ccc cca gcc tgg gtc cgc cca gat aac gag gcc cca ccc aag 1152 Pro Asn Pro Pro Ala Trp Val Arg Pro Asp Asn Glu Ala Pro Pro Lys 370 375 380 gtg cct cag agg acc tca tct atc gcc act gcc ctt aac acc agt ggg 1200 Val Pro Gln Arg Thr Ser Ser Ile Ala Thr Ala Leu Asn Thr Ser Gly 385 390 395 400 gcc gga ggg tcc cgg cca gcc cag gca gtc cgt gcc agt aac ccc gac 1248 Ala Gly Gly Ser Arg Pro Ala Gln Ala Val Arg Ala Ser Asn Pro Asp 405 410 415 ctc agg agg agc gac cct ggc tgg gag cg gac agc gtc ctt cca 1296 Leu Arg Arg Ser Asp Pro Gly Trp Glu Arg Ser Asp Ser Val Leu Pro 420 425 430 gcc tct cac ggg cac ctc ccc cag gct ggc tca ctg gag cgg aac cgc 1344 Ala Ser His Gly His Leu Pro Gln Ala Gly Ser Leu Glu Arg Asn Arg 435 440 445 gtg gga gcc tcc tcc aaa ctg gac agc tcc cct gtg ctc tcc cct ggg 1392 Val Gly Ala Ser Ser Lys Leu Asp Ser Ser Pro Val Leu Ser Pro Gly 450 455 460 aat aaa gcc aag ccc gac gac cac cgc tca cgg cca ggc cgg ccc gca 1440 Asn Lys Ala Lys Pro Asp Asp His Arg Ser Arg Pro Gly Arg Pro Ala 465 470 475 475 480 agc tat aag cga gca att ggt gag gac ttt gtg ttg ctg gag cgg 1488 Ser Tyr Lys Arg Ala Ile Gly Glu Asp Phe Val Leu Leu Lys Glu Arg 485 490 495 act ctg gac gag gcc cct cgg cct ccc aag aag gcc atg gac tac tcg 1536 Thr Leu Asp Glu Ala Pro Arg Pro Pro Lys Lys Ala Met Asp Tyr Ser 500 505 510 tcg tcc agc gag gag gtg gaa agc agt gag gac gac gag gag gaa ggc 1584 Ser Ser Ser Glu Glu Val Glu Ser Ser Glu Asp Asp Glu Glu Glu Gly 515 520 525 gaa ggc ggg gca ggg agc aga gat acc cct ggg ggc cgc gat 1632 Glu Gly Gly Pro Ala Glu Gly Ser Arg Asp Thr Pro Gly Gly Arg Asp 530 535 540 ggg gat aca gac agc gtc agc acc atg gtg gtc cac gac gtc gag gag 1680 sp Thr Asp Ser Val Ser Thr Met Val Val His Asp Val Glu Glu 545 550 555 560 atc acc ggg acc cag ccc cca tac ggg ggc ggc acc atg gtg gtc cag 1728 Ile Thr Gly Thr Gln Pro Pro Tyr Gly Gly Gly Thr Met Val Val Gln 565 570 575 cgc acc cct gaa gag gag cgg aac ctg ctg cat gct gac agc aat ggg 1776 Arg Thr Pro Glu Glu Glu Arg Asn Leu Leu His Ala Asp Ser Asn Gly 580 585 590 tac aca aac ctg cct gac gtg gtg ccc agc cac tca ccc acc gag 1824 Tyr Thr Asn Leu Pro Asp Val Val Gln Pro Ser His Ser Pro Thr Glu 595 600 605 aac agc aaa ggc caa agc cca ccc tcg aag gat ggg agt ggt gac tac 1872 Asn Ser Lys Gly Gln Ser Pro Pro Ser Lys Asp Gly Ser Gly Asp Tyr 610 615 620 cag tct cgt ggg ctg gta aag gcc cct ggc aag agc tcg ttc acg atg 1920 Gln Ser Arg Gly Leu Val Lys Ala Pro Gly Lys Ser Ser Phe Thr Met 625 630 630 635 640 ttt gtg gat cta ggg atc tac cag cct gga ggc agt ggg gac agc atc 1968 Phe Val Asp Leu Gly Ile Tyr Gln Pro Gly Gly Ser Gly Asp Ser Ile 645 650 655 ccc atc aca gtg ggt gga gag ggc act cgg ctc gac g ctg cag tac 2016 Pro Ile Thr Val Gly Gly Glu Gly Thr Arg Leu Asp Gln Leu Gln Tyr 660 665 670 gac gtg agg aag ggt tct gtg gtc aac gtg aat ccc acc aac acc cgg 2064 Asp Val Arg Lys Gly Ser Val Val Asn Val Asn Pro Thr Asn Thr Arg 675 680 685 gcc cac agt gag acc cct gag atc cgg aag tac aag aag cga ttc aac 2112 Ala His Ser Glu Thr Pro Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn 690 695 700 tcc gag atc ctc tgt gca gcc ctt tgg ggg gtc aac ctg ctg gtg ggc 2160 Ser Glu Ile Leu Cys Ala Ala Leu Trp Gly Val Asn Leu Leu Val Gly 705 710 715 720 720 acg gag aac ggg ctg atg ttg ctg gac cga agt ggg cag Thr Glu Asn Gly Leu Met Leu Leu Asp Arg Ser Gly Gln Gly Lys Val 725 730 735 tat gga ctc att ggg cgg cga cgc ttc cag cag atg gat gtg ctg gag 2256 Tyr Gly Leu Ile Gly Arg Arg Arg Phe Gp Gln Mln Leu Glu 740 745 750 ggg ctc aac ctg ctc atc acc atc tca ggg aaa agg aac aaa ctg cgg 2304 Gly Leu Asn Leu Leu Ile Thr Ile Ser Gly Lys Arg Asn Lys Leu Arg 755 760 765 gtg tat tac ctg ccc tgg tgg aac aag att ctg cac aat gac cca 2352 Val Tyr Tyr Leu Ser Trp Leu Arg Asn Lys Ile Leu His Asn Asp Pro 770 775 780 gaa gtg gag aag aag cag ggc tgg acc acc gtg ggg gac atg gag ggc 2400 Glu Val Glu Lys Gln Gly Trp Thr Thr Val Gly Asp Met Glu Gly 785 790 795 800 tgc ggg cac tac cgt gtt gtg aaa tac gag cgg att aag ttc ctg gtc 2448 Cys Gly His Tyr Arg Val Val Lys Tyr Glu Arg Ile Lys Phe Leu Val 805 810 815 atc gcc ctc aag agc tcc gtg gag gtg tat gcc tgg gcc ccc aaa ccc 2496 Ile Ala Leu Lys Ser Ser Val Glu Val Tyr Ala Trp Ala Pro Lys Pro 820 825 830 tac cac aaa ttc atg gcc ttc aag tcc ttt gcc ccc cac cgc 2544 Tyr His Lys Phe Met Ala Phe Lys Ser Phe Ala Asp Leu Pro His Arg 835 840 845 cct ctg ctg gtc gac ctg aca gta gag gag ggg cag cgg ctc aag gtc 2592 Pro Leu Leu Val Asp Leu Thr Glu Gly Gln Arg Leu Lys Val 850 855 860 atc tat ggc tcc agt gct ggc ttc cat gct gtg gat gtc gac tcg ggg 2640 Ile Tyr Gly Ser Ser Ala Gly Phe His Ala Val Asp Val Asp Ser Gly 865 870 875 875 880 aac agc tat gac atc tac atc cct gtg cac atc cag agc cag atc acg 2688 Asn Ser Tyr Asp Ile Tyr Ile Pro Val His Ile Gln Ser Gln Ile Thr 885 890 895 c895 cat gcc atc atc ttc ctc ccc aac acc gac ggc atg gag atg ct 2736 Pro His Ala Ile Ile Phe Leu Pro Asn Thr Asp Gly Met Glu Met Leu 900 905 910 ctg tgc tac gag gac gag ggt gtc tac gtc aac acg tac ggg cgc atc 2784 Leu Cys Tyr Glu Asp Glu Gly Val Tyr Val Asn Thr Gly Arg Ile 915 920 925 att aag gat gtg gtg ctg cag tgg ggg gag atg cct act tct gtg gcc 2832 Ile Lys Asp Val Val Leu Gln Trp Gly Glu Met Pro Thr Ser Val Ala 930 935 940 tac atc tgc tcc aac cag ata ggc tgg ggt gag aaa gcc att gag 2880 Tyr Ile Cys Ser Asn Gln Ile Met Gly Trp Gly Glu Lys Ala Ile Glu 945 950 955 960 atc cgc tct gtg gag acg ggc cac ctc gac ggg gtc ttc atg cac aaa 29 Glu Thr Gly His Leu Asp Gly Val Phe Met His Lys 965 970 975 cga gct cag agg ctc aag ttc ctg tgt gag cgg aat gac aag gtg ttt 2976 Arg Ala Gln Arg Leu Lys Phe Leu Cys Glu Arg Asn Asp Lys Val Phe 980 985 990 ttt gcc tca gtc cgc tct ggg ggc agc agc caa gtt tac ttc atg act 3024 Phe Ala Ser Val Arg Ser Gly Gly Ser Ser Gln Val Tyr Phe Met Thr 995 1000 1005 ctg aac cgt aac tgc atc atg agg tgg tg 3071 Leu Asn Arg Asn Cys Ile Met Asn Trp 1010 1015 gctgtcccac actggaccca gctctccccc tgcagccagg cttcccgggc cgcccctctt 3131 tcccctccct gggcttttgc ttttactggt ttgatttcac tggagcctgc tgggaacgtg 3191 acctctgacc cctgatgctt tcgtgatcac gtgaccatcc tcttccccaa catgtcctct 3251 tcccaaaact gtgcctgtcc ccagcttctg gggagggaca cagcttcccc ttcccaggaa 3311 ttgagtgggc ctagcccctc cccccttttc tccatttgag aggagagtgc ttggggcttg 3371 aaccccttac cccactgctg ctgactgggc agggccctgg acccctttat ttgcacgtca 3431 ggggagccgg ctcccccctt gaatgtacca gaccctgggg ggggtcactg ggccctagat 3491 ttttgggggg tcaccagcca ctccaggggc agggaccatt tcttcatttt ctgaaagcac 3551 tttaatgatt ccccttcccc caaactccag ggaatggagg ggggaccccg ccagccaaaa 3611 cattcccccc attcccgacc cccatctcct cttctagccc atgcccttcc ccggtggagg 3671 gagggagcag ggagccctca ctctccacgc cccttgcttg catctgtata tagtgtgagc 3731 agcaagtaac ccttctccct ccccccccac ccctcctcaa tgtagtggcc ttggatatcc 3791 tgtttgttaa taaagacaat tcaaccagct ccc 3824 <210> 91 <211> 4382 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1317) <400> 91 tgc acg gcc tgg tgt gtc atc atc gcc acg ctg gtg tgc agc gcc ggc 48 Cys Thr Ala Trp Cys Val Ile Ile Ala Thr Leu Val Cys Ser Ala Gly 1 5 10 15 atc gca gtg gga ttc tac ggc aac ggg gag acc agt gat ggc atc cat 96 Ile Ala Val Gly Phe Tyr Gly Asn Gly Glu Thr Ser Asp Gly Ile His 20 25 30 agg gcc acc tac tcg ctc cgc cac gcc aac cgc acg gtg gcc ggg gtc 144 Arg Ala Thr Tyr Ser Leu Arg His Ala Asn Arg Thr Val Ala Gly Val 35 40 45 cag gac cgc gtg tgg gac acg gcg gtg ggg ctg aac cac acg gcg gag 192 Gln Asp Arg Val Trp Asp Thr Ala Val Gly Leu Asn His Thr Ala Glu 50 55 60 ccc agc ctg cag acc ctg gag cgg cag ctg gcc ggg cgg ccc gag ccc 240 Pro Ser Leu Gln Thr Leu Glu Arg Gln Leu Ala Gly Arg Pro Glu Pro 65 70 75 80 ctg cga gcc gta cag agg ctg cag ggc ctg ctg gag acg ctg ggc 288 Leu Arg Ala Val Gln Arg Leu Gln Gly Leu Leu Glu Thr Leu Leu Gly 85 90 95 tac acg gcc gcc atc ccc ttt tgg agg aac acg gcg gtg tcg ctg gag 336 Tyr Thr Ala Ala Ila Pro Phe Trp Arg Asn Thr Ala Val Ser Leu Glu 100 105 11 0 gtg ctg gcg gag cag gtg gat ctc tac gac tgg tac agg tgg ctg ggc 384 Val Leu Ala Glu Gln Val Asp Leu Tyr Asp Trp Tyr Arg Trp Leu Gly 115 120 125 tac ctg ggc ctg ctg ctg ctg gc ctg atc gc ctg gtg ctg 432 Tyr Leu Gly Leu Leu Leu Leu Asp Val Ile Ile Cys Leu Leu Val Leu 130 135 140 gtt ggc ctc atc cgc agc tcc aag ggc atc ctg gtg ggg gtc tgc ctg 480 Val Gly Leu Ile Arg Ser Leu Val Gly Val Cys Leu 145 150 155 160 ctg gga gtc ctg gcc ctg gtc atc agc tgg ggc gcg ctg ggc ttg gag 528 Leu Gly Val Leu Ala Leu Val Ile Ser Trp Gly Ala Leu Gly Leu Glu 165 170 ct g gtg ggc tcc agc gac ttc tgt gtg gac cct gac gcc 576 Leu Ala Val Ser Val Gly Ser Ser Asp Phe Cys Val Asp Pro Asp Ala 180 185 190 tac gtg acc aaa atg gtg gag gag tac tcg gtg ctg agt ggg gyr atc 624 Val Thr Lys Met Val Glu Glu Tyr Ser Val Leu Ser Gly Asp Ile 195 200 205 ctg cag tac tac ctg gcc tgc tcg ccc cgc gcc gcc aac ccc ttc cag 672 Leu Gln Tyr Tyr Leu Ala Cys Ser Pro Arg Ala Ala Asn Pro Phe G ln 210 215 220 cag aag ctg tcg ggc agc cac aag gca ctg gtg gag atg cag gat gtc 720 Gln Lys Leu Ser Gly Ser His Lys Ala Leu Val Glu Met Gln Asp Val 225 230 235 240 gtg gct gag ctt ctg agg acc gtc c tgg gag cag ccg gcc act aag 768 Val Ala Glu Leu Leu Arg Thr Val Pro Trp Glu Gln Pro Ala Thr Lys 245 250 255 gac ccc ctc ctc cgc gtc cag gag gtg ctg aat ggc acg gag gtg aac 816 Asp Pro Leu Leu Arg Gln Glu Val Leu Asn Gly Thr Glu Val Asn 260 265 270 ctg cag cac ctc acc gcc ctg gtg gac tgc cgc agc ctg cat ctg gac 864 Leu Gln His Leu Thr Ala Leu Val Asp Cys Arg Ser Leu His Leu Asp 275 280 tac gtg caa gcg ctg acc ggc ttc tgc tat gac ggc gtg gag ggc ctc 912 Tyr Val Gln Ala Leu Thr Gly Phe Cys Tyr Asp Gly Val Glu Gly Leu 290 295 300 atc tac ctg gcc ctc ttc ttc ttc ttc gtc ttc ttc gtc ttc gtc ttc ttc gtc ttc gtc ttc ttc gtc ttc gtc ttc ttc gtc ttc ttc ttc ttc gtc tcc 960 Ile Tyr Leu Ala Leu Phe Ser Phe Val Thr Ala Leu Met Phe Ser Ser 305 310 315 320 atc gtc tgc agc gtc ccg cac acc tgg cag caa aag aga ggc cct gat 1008 Ile Val Cys Ser Val Pro His Thr Trp Gln GlnLys Arg Gly Pro Asp 325 330 335 gag gac ggg gag gag gag gcc gct cca ggg ccg cgg cag gcg cac gac 1056 Glu Asp Gly Glu Glu Glu Ala Ala Pro Gly Pro Arg Gln Ala His Asp 340 345 345 350 agc ctc tac cgc gtc atg ccc agc ctg tac agc tgt ggc agc agc 1104 Ser Leu Tyr Arg Val His Met Pro Ser Leu Tyr Ser Cys Gly Ser Ser 355 360 365 tac ggc agt gag acc agc atc ccg gcc gcg gcc cac acc gtc agc aac 1152 Tyr Glu Thr Ser Ile Pro Ala Ala Ala His Thr Val Ser Asn 370 375 380 gcc ccg gtc act gag tac atg agc cag aac gct aat ttc cag aac ccc 1200 Ala Pro Val Thr Glu Tyr Met Ser Gln Asn Ala Asn Phe Gln Asn Pro 385 390 395 400 cgc tgt gag aac acc cca ctc att ggg cgc gag tcc ccg ccg ccc tca 1248 Arg Cys Glu Asn Thr Pro Leu Ile Gly Arg Glu Ser Pro Pro Pro Ser 405 410 415 tac acc tcc agc atg aga gcc aaa tac ccc gcc acg agc cag cct cgc 1296 Tyr Thr Ser Ser Met Arg Ala Lys Tyr Leu Ala Thr Ser Gln Pro Arg 420 425 430 cct gac tcc agc ggc agc cac tagaccgcgc ccggcagcca cccaccccac 1347 Pro Asp Ser Ser Gly Ser His 435 gtgccaactt cccctccccg tgccagcact gccgcttcca cctgggccac ccaccggacc 1407 ctcgcacgcc gtgccaggcc tgccccagac gcgtctgcag gccgcttgcc ctcctgtccc 1467 ctccccgcag gggcacagtg gagacgcagg ggctctgggc ccgtaccgcc aactcgggtc 1527 acacctgaac gctgctgcca gccgatgccc cagccctgca cgccacccac tatcccggca 1587 cgctccctct gcagatggtc gccgcaccta caagccctgg ccgcacccaa cctgtgttgt 1647 tgccgcccgg cccttccctc cacagctctc cttcctcccg cccggcactt ctgtggaccc 1707 cttcttagtt cacaggcacg gctggggccg ctctgtgctg gcgcctgctg gccactgagg 1767 gacagggaca cgtgccacct gctcatctct gccctgaggt caccccgtgg tccctccacg 1827 tgcccatctc tctgcagtgc cctcctcgcc tgtgcagccc gcccacccac aggctcaccc 1887 ctcctgccgg ctgccagagg ccccctccag cagggcctct ctccgttgcc ccagcttcac 1947 tctctccctc agcacctgcc ctgctggagg ccccagccct ccgtggacag caggggccac 2007 gtggagcccg ggccgctcac ccgccaccca gtgctggccg ccttcttggt gccaaacccc 2067 cttcccccac ccagagactg ggcagctgtg tctggttcgt tctttgcact aaccacattt 2127 gtcatctcta gggcaggctg gggctgcggg ctgaggggga ccgctggcac cccccttccc 2187 t cccttcttg gttccatttc catccatgac aggtacagca tcccaggagc ccggcctgag 2247 gggctggacc cgagctggct gtgaacatcc ctcagcccct gctgtccccc cttgggacta 2307 accactaacc tcacccccaa actccacggg tgcccctagc tggcccagag ccggcagtgt 2367 gagcccaagt ccgggctgga gccgaggccg gagcagctgt ctgggagtca aggctgcagt 2427 agcgtttctt catggggtgc tccagggggt gccacagacc gacaggcagc ccaagggcct 2487 ggacacccct ccccaggcag gtgctgcccc aggaggactg tcctcgggaa tgaacctccc 2547 gcgggctttg gactgaggtc cctgtggcct cggtctcctc cccatgaagt gggagcgagg 2607 ctccccaatg gtgcttttgg ctttagtgta cgatgtttgc tgtgcttccc gccgtggagg 2667 gcagagccac cccacatcag gatcggacgt gctacccctc ccggtcccgg ccctggccca 2727 gccagcccag ccctcgaggc tcgatgcctg tgccaaggcc aggggcagcc agagggcagc 2787 tggatggcca cgtgcagggg tcaaggctgg gccctgcagt ggggcgggcc gccagcccca 2847 gcagtttaca gacgcatggc tcttcctccc agagcagccg gcagctacct ggaccggaaa 2907 tgtcctcatc ccctccctgg ggccaggctc tgccctggcc ttcctctgtg aacccctcct 2967 ttctttgtgc tggtgtctgg gaccaaaaag ggggaatatg ggagggcaga gtggggaggg 3027 gagtcc atgg gcctggggcc ccaagccggg gcgtctgagc tccccaggca tgaccaaacc 3087 tcagtggagg ggcctctgct tcaggccccg cctggctgac attctgagcc cccctcggag 3147 gccccgccac agccaacctg cccagtcttt cctctgggct tgacccgcca ggggagttct 3207 ccaggcctag ggccaggaga gaggccctgg caccctggcg tgggtgcccg ccaaacgccc 3267 tgcgaccgct cagaagcaca aatgctgtcc atggccgtga ggctgcctgc caggtgaatg 3327 gacatagcgt gagaggcggt gaggccaggg cttccagcct cgtgctgtct cgggactcct 3387 gaccgtggtg tgcgtgtgtg cccgtctgtg actttctact caccaaggtt gaagaaagga 3447 aacggggaaa atcaaaaggg gttcaaaccc cacctcagta ggtggagggg agcgcctgcc 3507 attggttgta tttttgttct gagttttcgg tgccgtgttc ctaactactc catcccatga 3567 cctcgccaca cctactgggg catctggctg gtgcctgctg ccatggccag cccccactct 3627 caccctgcac agggggtctt gcagccccca ggcccacagc ctcgttggga ggacagggtg 3687 gccctgggga caagagggag gagcccaggg gcttacctca ctgagagtgc tccccagcag 3747 gcatccacta ccccagggcc ccccacatgt catggcaagg ttggtagtga atgggcctgg 3807 ttgggagcag cccctggccc attgcccacc cacccatctc actatgcaat tcgagttcca 3867 agcaacattt g ctcctgccc tggggccagc tctgccccag ccctgagagg ggtggtgagg 3927 cagccccctg gaccccagaa ccccagacaa gggggcaggc gggggaccag ggcctctcct 3987 gtgggatctt tgttttgtgt ttaaccataa tggttgtgta ctgaaccact tcatatttgt 4047 tatatataat atatatatat ataatctcct taagactcag cctcctggtt tacccccccg 4107 gcctgggcat ctgacctccc ccaccccagt gtgatttaac atccaggaac tgaggcctga 4167 accattttgc atttccccct cctccagcct ctgtagggcc atggctgtat gtactgtcgc 4227 tgtgtttttt tgttttttta gaactgggtt tgggggctga tttttatttc tttgggggct 4287 tttttttctt ggcaaatact aaaaatctcg tcaatgtaat ttctgtggtt tctattcagc 4347 ttgggtttca tgttttaaaa taaattttaa aaagc 4382 <210> 92 <211> 4094 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1107) <400> 92 ctg gac ctt act gtc aga aag tct cag tca gaa cct agc gaa caa gac 48 Leu Asp Leu Thr Val Arg Lys Ser Gln Ser Glu Pro Ser Glu Gln Asp 1 5 10 15 ggt gta ctt gat ctg tcc act aag aaa agt cca tgt gct ggc agc act 96 Gly Val Leu Asp Leu Ser Thr Lys Lys Ser Pro Cys Ala Gly Ser Thr 20 25 30 tcc ctg agc cac tct cca ggc tgc tcc agt act caa ggg aac ggg cga 144 Ser Leu Ser His Ser Pro Gly Cys Ser Ser Thr Gln Gly Asn Gly Arg 35 40 45 cct ggg aga ccc agc cag tac cgc cca gac gga ctt cgg agt ggt gat 192 Pro Gly Arg Pro Ser Gln Tyr Arg Pro Asp Gly Leu Arg Ser Gly Asp 50 55 60 ggg gta cct cca aga agc tta cag gat gga acc agg gaa ggt ttt gga 240 Gly Val Pro Pro Arg Ser Leu Gln Asp Gly Thr Arg Glu Gly Phe Gly 65 70 75 80 cac tcc aca tca ctc aaa gtt cca ctg gct cga tcc ctg cag att agt 288 His Ser Thr Ser Leu Lys Val Pro Leu Ala Arg Ser Leu Gln Ile Ser 85 90 95 gaa gaa cta ctg agc aga aac caa ttg tcc aca gct gcc agc ctt ggg 336 Glu Glu Leu Leu Ser Arg Asn Gln Leu Ser Thr Ala Ala Ser Leu Gly 100 105 110 cca tct gga tta cag aat cat gga caa cac tta ata tta tcc agg gaa 384 Pro Ser Gly Leu Gln Asn His Gly Gln His Leu Ile Leu Ser Arg Glu 115 120 125 gcc tct tgg gca aaa cca cat tac gag ttc aac ctc agc cgt atg aag 432 Ala Ser Trp Ala Lys Pro His Tyr Glu Phe Asn Leu Ser Arg Met Lys 130 135 140 ttc agg gga aat ggt gca ctc agc aac atc agt agt gac ctt cct ttt ctt 480 Phe Arg Gly Asn Gly Ala Leu Ser Asn Ile Ser Asp Leu Pro Phe Leu 145 150 155 160 gca gaa aac tct gcc ttt cca aaa atg gca ctt caa gca aaa caa gat 528 Ala Glu Asn Ser Ala Phe Pro Lys Met Ala Leu Gln Ala Lys Gln Asp 165 170 175 gga aaa aag gat gtg agc cat tca tct cct gta gat tta aag ata cca 576 Gly Lys Lys Asp Val Ser His Ser Ser Pro Val Asp Leu Lys Ile Pro 180 185 190 caa gtt cga gga atg gat ctt tct tgg gag tct cgc act ggt gat cag 624 Gln Val Arg Gly Met Asp Leu Ser Trp Glu Ser Arg Thr Gly Asp Gln 195 200 205 tac agc tat agc tct ttg gta atg ggt tca caa acg gag agc gcg ctt 672 Tyr Ser Tyr Ser Ser Leu Val Met Gly Ser Gln Thr Glu Ser Ala Le u 210 215 220 agt aaa aaa tta agg gct att ctt cca aaa caa agt aga aaa agc atg 720 Ser Lys Lys Leu Arg Ala Ile Leu Pro Lys Gln Ser Arg Lys Ser Met 225 230 235 240 tta gat gct gga ccc gat tct tgg ggc tca gat gct gag cag tct acc 768 Leu Asp Ala Gly Pro Asp Ser Trp Gly Ser Asp Ala Glu Gln Ser Thr 245 250 255 tct gga cag cca tat ccc aca tcg gat caa gaa gga gac cct ggc tcc 816 Ser Gly Gln Pro Tyr Pro Thr Ser Asp Gln Glu Gly Asp Pro Gly Ser 260 265 270 270 aag cag cct cgg aag aaa aga ggg cgt tac aga cag tac aac agt gag 864 Lys Gln Pro Arg Lys Lys Arg Gly Arg Tyr Arg Gln Tyr Asn Ser Glu 275 280 285 ata ctg gag gaa gca atc tca gtg gtt atg agt gga aaa atg agt gtt 912 Ile Leu Glu Glu Ala Ile Ser Val Val Met Ser Gly Lys Met Ser Val 290 295 300 tcc aaa gct cag agt att tat ggg att ccc cac agt aca ctg gag tac 960 Ser Lys Ala Gln Ser Ile Tyr Gly Ile Pro His Ser Thr Leu Glu Tyr 305 310 315 320 aaa gta aag gag agg ctg ggc act ttg aaa aac cct cca aag aaa aag 1008 Lys Val Lys Glu Arg Leu Gly Thr Leu Lys AsnPro Pro Lys Lys Lys 325 330 335 atg aaa tta atg agg tcg gag ggg cca gat gtt tct gta aag att gaa 1056 Met Lys Leu Met Arg Ser Glu Gly Pro Asp Val Ser Val Lys Ile Glu 340 345 350 tta gat ccc cag gga gag gca gca caa agt gca aat gaa tca aaa aac 1104 Leu Asp Pro Gln Gly Glu Ala Ala Gln Ser Ala Asn Glu Ser Lys Asn 355 360 365 gag taggaatact gtagagtgcc aattactgta caaactgggt gagcactact 1157 Glu gcatcattgt tcagctatca ttgcttgcac gtaatttcat ttactgtgac acttgcttct 1217 ttgcagattt tgcattgact tgtgtgtaca gagatgaaat gtgcattctg aatgttgcat 1277 attttaaatt tttcatgtgc agtatggctc ggaatatgtt tggccttttg catgtttctc 1337 tacaaaagag aattgagtta cctcacagag aacagataca tggaagtgga ctccttgcct 1397 gtagagcctg catgcttttt tgtttttttt tgttgttgtt gttttttctt aagttatatt 1457 tgtttttact ttttaaaaaa gaagaggaaa caaagccccc ttttagaaac tacgtctgtc 1517 atactgggag ctttatcact gcaaattgga aagccatctt atacaaaatt attcacattt 1577 ttcatctacg attcaactaa tcgaaggatt aaactaaaga aaaaactaag aagaacaatg 1637 aacctttgac tttgagaaat ttggttattc actgacata a ttattgggtc atttatagtt 1697 acattttata attttcttct cactattaaa tttatttaaa ttagcaagct attagtgctc 1757 acccagaggg gaaggtggtg gaaaatgtgc acacactacc ttcagaaatg cttcagttaa 1817 ttactttgaa cactaccttt gctgtaattt catttgagat tttctaaggg tagaatttgg 1877 tctcaccaac aagtgaggat atagccttat ctcatggagg acgagctccg tatttactca 1937 ggagcagtca gggtacatta cataaaacaa tggaggatgc ctcattttag caaactaggt 1997 ttctttgtat tcttcagtcc ttttacagaa ttgatgtgct aactgaatat cattgcagca 2057 actagactaa gatattcaag atctctttat tggggatggg agaaataggg aaagaaatgt 2117 gtataagtaa ttatgatatt gcaaaagtga tacttagatt ttacagcctc agtagtctgc 2177 ccagtgtcca cattaatgaa ggatccatgt ttgtagtgag agaaaaaaac cccaaggtaa 2237 cccgatatga tttaggatgc atatcagttc taacaattca atcagaagtc aagctcattg 2297 gaattccttt tttaactgat ccaaatacta gtagaagggg gagggagagg tgttgggttt 2357 tttttttaag tttttattta attttgttgg ttagaatttt tttctgtttt tggcatccta 2417 cataataccc cccttcttga ctttttctga taattagctg atattcatgg ttgtttagca 2477 cacagttcag gacctttgag atcatgtttg tataagcact cct tgaagaa tatctaagct 2537 ttttctgaga tgggctttta aaattataat aagggaagtt tattttctgc ggtttttgca 2597 agaataagca aagcccatgg aatttaattt ttcattgtga tcagattaaa attactattt 2657 gtgcaaaaca aattccacac cacatgtact gtatattcta atctgctgag aaaggtggtc 2717 aggcccttct aaatgcttaa ccaaaaacaa acattattgg agtttcagtg taaaataaaa 2777 ttaaaattgg agggttggtt agattgattt cagatggata ctaacagttt gaggggaggt 2837 ccagatattt ccaaggcata aattcttgcc tggaaacttt ggagcaatta attaaattag 2897 gttaagtttt ccctcagcaa cctgtgtgtt caaaggttag gcacaccatt gctgttacta 2957 aaatacatgc actgctcatt cttgacatag cttgggtgtg ggttcctctt gttttggtta 3017 ttttgtgtag cagtttaatc agtggataac tgagcctgtt tcctcttagc tttctagact 3077 tcttaacaga aaaaacagtt tgggttcaat agcattttat gattctacaa tattttgtca 3137 cctagctgga agttgcaata aaaattcctt atgaaatata tggttttcat ctgtaattga 3197 aggaaatcat agaaagtttg ctgaaagcaa agggctaagc ttatgaagga atgcctcctt 3257 tgttacacac tcaagaattt gtcagcacac aattaattgc agccatagta cctttttgcg 3317 taatgtttgg gatattcagt agcccaggat tgctacaaaa aggtccttt g agaaaattaa 3377 tttgtgcttg cttttatccc ctctcagaaa gacatcacta aaggcccatt aaaaatctgg 3437 ccctaaaagt tcaacttttg tagagtttat tgttcagaga ggtttaatcc tatgtggtag 3497 tctatataag tgatgtatga gttgagttat gtaaattttg tcattgtagt gtacatggag 3557 tgatcatttt actaacataa atattttcta tgtgtgtttc agtggatgac aatcgagcag 3617 cagaagaatg gtgtgcctac cctttaatgc tgcagtttaa gagaacttgt attgtgtcat 3677 ttcagattgt aggctgagag ttgtaaatag tgaaaatttg agtacttcta ttatttgttt 3737 tggttagaaa gtgaatttaa aaaacaaacc aaactctaaa ctttctcaga ttaaaagtcc 3797 tgagacctga agattgtaat attcatgtct gtgaagcttt taaacattac acttgagatc 3857 agtcatgact tgatattcag gtaaattttc ttttccaaga agcttttgaa taagcatatt 3917 tcctccaaag gtctctctct ttctctctct ttttttgagt gtagattatt ttaaagcact 3977 aattgcatta cattggtaac tgcaatataa aatagccatt attgttttgt gaagcatggt 4037 tgaaattagc tagtggtccc ttttgaattt catgagcctc tcaaaaaaga aaaactt 4094 <210> 93 <211> 4370 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1139) <400> 93 ac aag gaa gac ttt aat gaa ctc ctg cac aaa gtc agt aaa gaa ctg 47 Lys Glu Asp Phe Asn Glu Leu Leu His Lys Val Ser Lys Glu Leu 1 5 10 15 gca gaa tgg tat ttt caa gat ggt cga gca gta cta gcc gca tgt tgc 95 Ala Glu Trp Tyr Phe Gln Asp Gly Arg Ala Val Leu Ala Ala Cys Cys 20 25 30 cat ctt gcc ata gat aat att gag ctt gct atg gca tac ctg att cgc 143 His Leu Ala Ile Asp Asn Ile Glu Leu Ala Met Ala Tyr Leu Ile Arg 35 40 45 gga aat gaa ctg gag ttg gca gtc tgt gtg ggc aca gta cta gga gag 191 Gly Asn Glu Leu Glu Leu Ala Val Cys Val Gly Thr Val Leu Gly Glu 50 55 60 tct gca gca cca gca acc cac tat gcc tta gaa tta ctg gcg aga aag 239 Ser Ala Ala Pro Ala Thr His Tyr Ala Leu Glu Leu Leu Ala Arg Lys 65 70 75 tgc atg atg att tca gta tgc ttt cca tgt gtt gga tac agg aattt 287 Cys Met Met Ile Ser Val Cys Phe Pro Cys Val Gly Tyr Arg Asn Leu 80 85 90 95 gca gct gat ctt ctt ctg atg att cct gat aat gaa cta cat tta ata 335 Ala Ala Asp Leu Leu Leu Met Ile Pro Asp Asn Glu Leu His Leu Ile 100 105 110 aaa ctc tgt gct ttc tac cca gga tgt act gaa gag ata aat gac ctt 383 Lys Leu Cys Ala Phe Tyr Pro Gly Cys Thr Glu Glu Ile Asn Asp Leu 115 120 125 cat gat aag tgt aag cta ccc aca gtg gaa gaa tgt atg cag gct 431 His Asp Lys Cys Lys Leu Pro Thr Val Glu Glu Cys Met Gln Leu Ala 130 135 140 gag aca gcc cgt gca gat gac aat ata ttt gaa act gta aaa tat tac 479 Glu Thr Ala Arg Ala Asp Asp Asn Ile Phe Glu Thr Val Lys Tyr Tyr 145 150 155 ttg tta agt caa gaa cct gaa aaa gcc ctt cct att ggt att agc ttt 527 Leu Leu Ser Gln Glu Pro Glu Lys Ala Leu Pro Ile Gly Ile Ser Phe 160 165 170 175 gtt aaa gaa tac atc agt agc tca gac tgg act ttg gat acc ata tac 575 Val Lys Glu Tyr Ile Ser Ser Ser Asp Trp Thr Leu Asp Thr Ile Tyr 180 185 190 cct gtt ctt gac cta ctg agc tat att cgt act gaa aaa tta ctc ttg 623 Pro Val Leu Asp Leu Leu Ser Tyr Ile Arg Thr Glu Lys Leu Leu Leu 195 200 205 cat acg tgt act gaa gct cga aat gag ttg ctg ata tta tgt ggt tac 671 His Thr Cys Thr Glu Ala Arg Asn Glu Leu Leu Ile Leu Cys Gly Tyr 210 215 220 att ggt gca tta ctg gct atc aga aga cag tac caa agc att gtt cca 719 Ile Gly Ala Leu Leu Ala Ile Arg Arg Gln Tyr Gln Ser Ile Val Pro 225 230 235 gca ctt tat gag tac aca agt cag cta tta aaa cgt cgg gag gtg tca 767 Ala Leu Tyr Glu Tyr Thr Ser Gln Leu Leu Lys Arg Arg Glu Val Ser 240 245 250 255 gta cct tta aaa att gaa tat ctt tct gag gaa ttg gat gca tgg aga 815 Val Pro Leu Lys Ile Glu Tyr Leu Ser Glu Glu Leu Asp Ala Trp Arg 260 265 270 gct tgc aca cag tcc acc aac aga tca tta gaa gac tct ccg tat aca 863 Ala Cys Thr Gln Ser Thr Asn Arg Ser Leu Glu Asp Ser Pro Tyr Thr 275 280 285 ccc cct tct gat tca caa aga atg att tat gca act tta tta aag aga 911 Pro Pro Ser Asp Ser Gln Arg Met Ile Tyr Ala Thr Leu Leu Lys Arg 290 295 300 cta aaa gaa gag tca ctg aaa gga att att gga cca gat tat gtg act 959 Leu Lys Glu Glu Ser Leu Lys Gly Ile Ile Gly Pro Asp Tyr Val Thr 305 310 315 gga tca aat ctt cca agt cat tct gat att cac att tct tgt ctt acg 1007 Gly Ser Asn Leu Pro Ser His Ser Asp Ile His Ile Ser C ys Leu Thr 320 325 330 335 gga tta aaa atc cag ggc cct gtg ttt ttc ctt gaa gac ggg aaa tct 1055 Gly Leu Lys Ile Gln Gly Pro Val Phe Phe Leu Glu Asp Gly Lys Ser 340 345 350 act atc tcc ttg aat gat gct ttg atg tgg gca aag gtg aat cca ttc 1103 Thr Ile Ser Leu Asn Asp Ala Leu Met Trp Ala Lys Val Asn Pro Phe 355 360 365 tca cct tta ggg act gga ata cga ctc aat cca ttc tgatagaaga 1149 Ser Pro Leu Gly Thr Gly Ile Arg Leu Asn Pro Phe 370 375 tttttgtcca tgcttgattt ttttttttaa agaaaaactt tcatgggtta gcattacctt 1209 aatctttgtt gctcaagtgc cagaggttgg gagaaggatt gcaggttggg agaggtggga 1269 aatagcagtg aattttagtc attaacttca aaatatatat atatatataa tttaaaggaa 1329 aaataggtgc ctcctttata aacagtaata gctacgtttg ggaaggagga aacatttaaa 1389 ttataaagga ctgaataatc taaaaagcat ataaaagttt cacacagcat aaaagatacc 1449 aaaatatcat atggttgaaa tattgaaaca tattaaattg tgcaacacct agaatagtgc 1509 tagacataca gtaagtactt aatggatatt tgaatgattg aatatcttga aatgttgaaa 1569 tgtaaggtgt gcacagtgat cttcaactta acaaacactt acgttctcct ttataaaatg 1629 catagtaaac cactaacgtt agctgtttta ataaaagttt tcagttataa gtttagtaaa 1689 tattaataaa tggatacaca ttcaaaatac ttttaaaaaa aagaaaatgt taccagtttt 1749 tttatctgaa gtttaactgt cccattgtaa aggtgtaagt tatataggct tgaaaaaaat 1809 tggcgggtaa aaatcacaaa atgcagtcga atatatatat gaaaacttgc attaggtgat 1869 aaagtgacta ttttaagaga ttcagcatgc atggatatta gttttgatta atgtgtacaa 1929 taatttacac agtatactct agtcaattta tgttaacttt atttaaaaca caatttattt 1989 ggccgggcac ggtggctcac acctgtaatc tcagcacttt ggcaggccaa ggcaggtgga 2049 tcacctgagg tcaggagttc atgaccagcc tggccagcat ggtaaaaccc tgtctccact 2109 aaaaatacaa aaattagcca ggcatggtgg cgggcacctg taatcccagt tacttgggaa 2169 gctgaggcag gagaatccct tgaacctggg aggcagaggt tccagtgagc caagatcgca 2229 ccactgcact ccagcctggg caacaaagag cgaaactctg tctcaaaaaa caaaccaaca 2289 aaaaccacaa ttgatttgat gaaaattagt tttaagtaaa tgtttgtaaa tagatattgg 2349 ttgaattttt ggatatatta tgttgattta acttttaaaa tgttgtttaa aagtgtgaag 2409 ctatgaaaag cctgataatg tgactacaga tatttcagtt ggactagaat tctgactttg 2469 aaacttatta aattaatgca tactggaagt actttgatac tcaagttgtt tcacaagatt 2529 tataatatag atggttttgt ttgactaaag aataatctca tataactaga atacttgtgg 2589 cttttattat ctttaaactt gttgcattta aaatattttt aaaaccttct taacaaaact 2649 tcttaaaact ggaaaaaata tatattatgt atctatgtat catatttatc acatgaccac 2709 ttttgattcc ttaaaaagac attacaggct taaattccat tttattaaaa aaaaaaattg 2769 cctgtaatcc cagcacttca ggaggccgag atgggcagat cttgaggtcg gtagatggag 2829 accatcctgg ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagctgggt 2889 gtggtggtgt gtacctgtag tcccagctac ccaggaagct aaggcaggag aatcgcttga 2949 atccaggagg cggaggttgc agtgagctga gatcgcacta ctgcactcca gcctgggcga 3009 cagagcaaga ccaccatctc caaaaattat atatataaaa ataattaata ttatagaaga 3069 gaatatacac aactcagaga tgcaatggat aatataaaaa gagtacctga gatgtatttt 3129 tttaaactct tagagatatc tgtaactcaa atttttctta ggtgaggagg attattaact 3189 ggcacatatg tactaaaaac ccctcactta aaaatggcag tctcaatcct actgtcatcc 3249 tttttatttt aaaataaata aataagccta tctttttgtg cttacatact taaaaggata 3309 tcatta agta tataaacaat cattacttct gtatttttaa tgaatgcagg aaaataatat 3369 ttttatgtat aaaaaatgaa gaaaaaattt tgcaagtctt taagcacata aatacaacag 3429 aatagccacc caatttctgt ctgaaatcta aattggatgg atttgaccat cattctatta 3489 tctttgattt ctacaatgtc tatatcttat tacctataac tattaatttt tcatagaatt 3549 ataaatgtca tttgactatg tcaatctgta tatattgtac cttaatatga aaaacaaatt 3609 ttttaattca taaaagtatt tttattagat ttcatatgca tgaaacccaa gcaaattata 3669 tgaatttatt ttactatttg aaaatgttca tattaccaat aatgtggaca aattactttg 3729 caggtttaaa tatgcctctg taaaggaaga gtctcattag acaatgattt ttaaagcatt 3789 ggaaaaatat tttgcctgta aaagttagta actaggtggt tcacaaaatt acaacatcaa 3849 aatagttaca tcttgtgaaa atatatgatt tttatgtcaa tcaagacaaa tgaaatatat 3909 atgtatgtgt atatatatac atgtatgtat gaaatatata tatgtgcgtg tgtgtgtgta 3969 tatatatata tatatatttc tatgaaattg tccagatgtg ttcaggaaca tgattgcatt 4029 agagcaatga ctgtattttg ttgtccttat aacatttata ttatttcagt tttaagtcaa 4089 aaggtattct gaatataata aaagcctcac aaattatttg taaaatttag tagttcatat 4149 ttagtatatc agtaatatag aagacatctt tatagtcaac tcttaattaa tgcttattgt 4209 accaaatctt tgagatattt gtacataaat gaaatatgta ctttcatgct aaaattatat 4269 atcatgactg tgctataatt tggcatgtca ttatctagat ttatatat gtacttattag 4329 caggattattag <210> 94 <211> 4044 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (170) .. (1639) <400> 94 gccaatgttg gagccgtctg caaagtgtcc ccggcaagaa gaggctgcct accacaagga 60 ctttagctta ctttttaaag attgaagaaa aaaaagaaga cagaaaaaga agaactcaaa 120 gatacacaaa gtaatttgaa ccaaggctca gaagtttttg gagccgtga ggg ata cag 178 Gly Ile Gln 1 cag ttt ggt caa tat tgt ctt aac atg ctt caa ata aat cag atg ttc 226 Gln Phe Gly Gln Tyr Cys Leu Asn Met Leu Gln Ile Asn Gln Met Phe 5 10 15 tca gtg cag ctg agt ctt ggt gag cag aca tgg gaa tcc gaa ggc agc 274 Ser Val Gln Leu Ser Leu Gly Glu Gln Thr Trp Glu Ser Glu Gly 20 25 30 35 agt ata aag aag gct cag cag gct gtt gcc aat aaa gct ttg act gaa 322 Ser Ile Lys Lys Ala Gln Gln Ala Val Ala Asn Lys Ala Leu Thr Glu 40 45 50 tct acg ctt ccc aaa cca gtt cag aag cca ccc aaa agt aat gtt aac 370 Ser Thr Leu Pro Lys Pro Val Gln Lys Pro Pro Lys Ser Asn Val Asn 55 60 65 aat aac cca ggc agt ata act cca act gtg gaa ctg aat ggg ctt gct 418 Asn Asn Pro Gly Ser Ile Thr Pro Thr Val Glu Leu Asn Gly Leu Ala 70 75 80 atg aaa agg gga gag cct gcc atc tac agg cca tta gat cca aag cca 466 Met Lys Arg Gly Glu Pro Ala Ile Tyr Arg Pro Leu Asp Pro Lys Pro 85 90 95 ttc cca aat tat aga gct aat tac aac ttt cgg ggc atg tac aat cag 514 Phe Pro Asn Tyr Arg Ala Asn Tyr Asn Phe Arg Gly Met Tyr Asn Gln 100 105 110 115 agg tat cat tgc cca gtg cct aag atc ttt tat gtt cag ctc act gta 562 Arg Tyr His Cys Pro Val Pro Lys Ile Phe Tyr Val Gln Leu Thr Val 120 125 130 gga aat aat gaa ttt ttt ggg gaa gga aag act cga caa gct gct aga 610 Gly Asn Asn Glu Phe Phe Gly Glu Gly Lys Thr Arg Gln Ala Ala Arg 135 140 145 cac aat gct gca atg aaa gcc ctc caa gca ctg cag aat gaa cct att Ala Asn Ala Met Lys Ala Leu Gln Ala Leu Gln Asn Glu Pro Ile 150 155 160 cca gaa aga tct cct cag aat ggt gaa tca gga aag gat gtg gat gat 706 Pro Glu Arg Ser Pro Gln Asn Gly Glu Ser Gly Lys Asp Val Asp Asp 165 170 175 gac aaa gat gca aat aag tct gag atc agc tta gtg ttt gaa att gct 754 Asp Lys Asp Ala Asn Lys Ser Glu Ile Ser Leu Val Phe Glu Ile Ala 180 185 190 195 ctg aag cga aat atg cct gtc gtt gtt gag att aaa gaa agt gga 802 Leu Lys Arg Asn Met Pro Val Ser Phe Glu Val Ile Lys Glu Ser Gly 200 205 210 cca cca cat atg aaa agc ttt gtt act cga gtg tca gta gga gag ttc 850 Pro Pro His Met Lys Ser Phe Val Thr Arg Val Ser Val Gly Glu Phe 215 220 225 tct gca gaa gga gaa gga aat agc aaa aaa ctc tcc aag aag cgc gct 898 Ser Ala Glu Gly Glu Glu Gly Asn Ser Lys Lys Leu Ser Lys Lys Arg Ala 230 235 240 gcg acc acc gtc tta cag gag ctt aaa aaa ctt cca cct ctt cct gtg 946 Ala Thr Thr Val Leu Gln Glu Leu Lys Lys Leu Pro Pro Leu Pro Val 245 250 255 gtg gaa aag cca aaa cta ttt ttt aaa aaa cgc cct aaa aca ata gta 994 Val Glu Lys Pro Lys Leu Phe Phe Lys Lys Arg Pro Lys Thr Ile Val 260 265 270 275 aag gcc gga cca gaa tat ggc caa ggg atg aac cct att agc cgc ctg 1042 Lys Ala Gly Pro Glu Tyr Gly Gln Gly Met Asn Pro Ile Ser Arg Leu 280 285 290 gcg caa att caa cag gcc aaa aag gaa aag gag ccg gat tat gtt ttg 1090 Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Asp Tyr Val Leu 295 300 305 ctt tca gaa aga gga atc cgt cga gaa ttt gtg atg cag gtg 1138 Leu Ser Glu Arg Gly Met Pro Arg Arg Arg Glu Phe Val Met Gln Val 310 315 320 aag gta ggc aat gaa gtt gct aca gga aca gga cct aat aaa aag ata 1186 Lys Val Gly Asn Glu Val Ala Thr Gly Thr Gly Pro Asn Lys Lys Ile 325 330 335 gcc aaa aaa aat gct gca gaa gca atg ctg tta caa ctt ggt tat aaa 1234 Ala Lys Lys Asn Ala Ala Glu Ala Met Leu Leu Gln Leu Gly Tyr Lys 340 345 350 355 gca tcc act aat ctt cag gat caa ctt gag aag aca ggg gaa aac aaa 1282 Ala Ser Thr Asn Leu Gln Asp Gln Leu Glu Lys Thr Gly Glu Asn Lys 360 365 370 gga tgg agt ggt cca aag cct ggg ttt cct gaa cca aca aat aat act 1330 Gly Trp Ser Gly Pro Lys Pro Gly Phe Pro Glu Pro Thr Asn Asn Thr 375 380 385 cca aaa gga att ctt cat ttg tct cct gat gtt tat caa gag atg gaa 1378 Pro Lys Gly Ile Leu His Leu Ser Pro Asp Val Tyr Gln Glu Met Glu 390 395 400 gcc agc cgc cac aaa gta atc tct ggc act act cta ggc tat ttg tca 1426 Ala Ser Arg His Lys Val Ile Ser Gly Thr Thr Leu Gly Tyr Leu Ser 405 410 415 ccc aaa gat atg aac caa cct tca agc tct ttc ttc agt ata tct ccc 1474 Pro Lys Asp Met Asn Gln Pro Ser Ser Ser Phe Phe Ser Ile Ser Pro 420 425 430 435 aca tcg aat agt tca gct aca att gcc agg gaa ctc ctt atg aat gga 1522 Thr Ser Asn Ser Ser Ala Thr Ile Ala Arg Glu Leu Leu Met Asn Gly 440 445 450 aca tct tct aca gct gaa gcc ata ggt tta aaa aaa gga agt tct cct act 1570 Thr Ser Ser Thr Ala Glu Ala Ile Gly Leu Lys Gly Ser Ser Pro Thr 455 460 465 ccc cct tgt tct cca gta caa cct tca aaa caa ctg gaa tat tta gca 1618 Pro Pro Cys Ser Pro Val Gln Pro Ser Lys Gln Leu Glu Tyr Leu Ala 470 475 480 agg att caa ggc ttt cag gta tgaattaaaa gcaaaaacaa aaaacaaaac 1669 Arg Ile Gln Gly Phe Gln Val 485 490 aattcattag cctcagattc ttcatctgta tacatcacaa ggctcattct tgcctgctag 1729 tatggcctac atgccactta cgttttaagt tatttaggaa cacaaaggac agacaaaaaa 1789 gccatatgca catgcctcat tttctcttat ttttgatcta tctagtaatt cttttgctgc 1849 ctgtctcttc tccattttcc ttcttctttt ttaagcattt ttcatattct tcactgtctt 1909 ctatttggtc ttgattaggt gcatctatct cttcgctc tg tcttccacaa acaaaaattc 1969 tgccttcaga catttggtgt tagtatttca cactcagttc tccctttttt tacataagga 2029 ttgagtttct ttttatgatg attttacctt tatagcaatt ttgaattttg cattctattg 2089 ctagtattga ttcaggtaca ccattaagat acaacattct agaagtctat taccttagga 2149 gttaattaaa catgatattt gaagaataat gaaatgcttt atagttgttt gaggcataac 2209 aatgtgtatt tgttttactg gatcatgttt tgaactgact agggagggta gcacctgcct 2269 cagatagtac caacaattct gtttcactgg gtagtctaaa actagcttat agtttaactt 2329 aacttgttgt gtatgtgaat ttagggatgg aaactttttt tcccctattt attctttgtt 2389 tccttctggg aaaaaacccc acaaaaatca gcactccttt atggatacat tggagctttt 2449 gaaagaattg taaactctag gaaggggaaa tatctgtgtc ttgatttctt agttgccttg 2509 aaaatcatgt actgaactgt aaccgctaac ttgactggat gaactagttt gcttgtgtgt 2569 agagagtgta ttgcttcctc agatttcact gttttcatct ccttttccat cttagtcttt 2629 attccttaag accaaaaact gtaatatcct ttagaaatgc tctagaagat ctgtattgtg 2689 tagaatgatc atgtatttat aaatatttta caagtttaga ttataaaatg aaaaagaagg 2749 tcatgtgttt tggggggtat tttgcatgtt cggatttttt tt tcccttca ccgaaccctt 2809 ctgattcttt caaactattg ccaggtagtt gttagtgttt ctaattggac tcttaatatg 2869 aacttcaaga agctgttacc agttatcggc tctgtcatct gaaattttaa ccacttaatt 2929 taaagttaca attttagaat ttgtttttgt tgttttacct taagaaacac aataaatcac 2989 tgtttaaaaa agatctcaat ttatataaag tactggaaaa aagctaagta atttttagtt 3049 ctatctataa tctccgtagg atgaattaga aataaattgt gatgaaaaga aattaactgc 3109 ttatttatga atctaatcat ttagaaatgt ctgagagtaa cactgcattc ttatagaaac 3169 aaagcacaaa ttgcattcaa gctctgaatt gattttttgc ttggagctgt tgttacagta 3229 gctgtaattt tgctaccaga atgtcttaat tttttaaatt tgtttttatt tctaagctct 3289 tggcaatgac aataattata attttaacat atcttcactg tagtcaacat gtagagtctg 3349 cttccctcat tattgcattg ctaaggcctt tttaaaaagc ttatgcttac ataatacact 3409 cttttttatg gacacgttat atgtttccaa atctgtgtat tgtgattttt acatactaat 3469 gaatataaac aggtgatttt aaaatattac tgtgcttctt tggttgaatg agctggtatt 3529 gatgtaaaat actctgtcat tgatggacca ctacctgcag ctaagcagtg agcagaatct 3589 ccgggaaatg acttagtctg gccacatgca tagcccatct tcataatg tc gcagcagaag 3649 gttctttgtg gttaaaagtt ttaaagccta tttctttata ggtaaccctc tcaggtatat 3709 ttacctggta gaaaaacatg tagattgttt ctattactta aatgttttaa ttggactgta 3769 gtttagaaat tacaggacca gcttgttaca gattatacac tattctgtta cttttatttc 3829 tgaaacttaa aaacaataaa ttctttttct gtgtttctag gttagaactt ttttatttta 3889 ttgcacactg aacagatact gttgcttatt gaatattgtg taaacccttc tttggctttc 3949 cttgcccatt gcaatttaat ttaagcctac tagagccatt gtatgtgaca gctatattgt 4009 attacaaagt aaaaatatat gagtgtattg aaaac 4044 <210> 95 <211> 2340 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (871) <400> 95 g gac ctg tcc tcc aac cgg ctg gag atg gtg aat gag tcg gtg ttg gcg 49 Asp Leu Ser Ser Asn Arg Leu Glu Met Val Asn Glu Ser Val Leu Ala 1 5 10 15 ggg ccg ggc tac acg acg ttg gct ggc ctg gat ctc agc cac aac ctg 97 Gly Pro Gly Tyr Thr Thr Leu Ala Gly Leu Asp Leu Ser His Asn Leu 20 25 30 ctc acc agc atc tca ccc act gcc ttc tcc cgc ctt cgc tac ctg gag 145 Leu Thr Ser Ile Ser Pro Thr Ala Phe Ser Arg Leu Arg Tyr Leu Glu 35 40 45 tcg ctt gac ctc agc cac aat ggc ctg aca gcc ctg cca gcc gag agc 193 Ser Leu Asp Leu Ser His Asn Gly Leu Thr Ala Leu Pro Ala Glu Ser 50 55 60 ttc acc agc tca ccc ctg agc gac gtg aac ctt agc cac aac cag ctc 241 Phe Thr Ser Ser Pro Leu Ser Asp Val Asn Leu Ser His Asn Gln Leu 65 70 75 80 cgg gag gtc tca gtg tct gcc ttc acg acg cac agt cag ggc cgg gca 289 Arg Glu Val Ser Val Ser Ala Phe Thr Thr His Ser Gln Gly Arg Ala 85 90 95 cta cac gtg gac ctc tcc cac aac ctc att cac cgc ctc gtg ccc cac 337 Leu His Val Asp Leu Ser His Asn Leu Ile His Arg Leu Val Pro His 100 105 1 10 ccc acg agg gcc ggc ctg cct gcg ccc acc att cag agc ctg aac ctg 385 Pro Thr Arg Ala Gly Leu Pro Ala Pro Thr Ile Gln Ser Leu Asn Leu 115 120 125 gcc tgg aac cgg ctc cat gcc gtg ccc aac ctc cga gac ttg ccc ctg 433 Ala Trp Asn Arg Leu His Ala Val Pro Asn Leu Arg Asp Leu Pro Leu 130 135 140 cgc tac ctg agc ctg gat ggg aac cct cta gct gtc att ggt ccg ggt 481 Arg Tyr Leu Ser Leu Asp Gly Asn Pro Ala Val Ile Gly Pro Gly 145 150 155 160 gcc ttc gcg ggg ctg gga ggc ctt aca cac ctg tct ctg gcc agc ctg 529 Ala Phe Ala Gly Leu Gly Gly Leu Thr His Leu Ser Leu Ala Ser Leu 165 170 175 cag agg ct gag ctg gcg ccc agt ggc ttc cgt gag cta ccg ggc 577 Gln Arg Leu Pro Glu Leu Ala Pro Ser Gly Phe Arg Glu Leu Pro Gly 180 185 190 ctg cag gtc ctg gac ctg tcg ggc aac ccc aag ctt gac gg agg ctt aac Gln Val Leu Asp Leu Ser Gly Asn Pro Lys Leu Asn Trp Ala Gly 195 200 205 gct gag gtg ttt tca ggc ctg agc tcc ctg cag gag ctg gac ctt tcg 673 Ala Glu Val Phe Ser Gly Leu Ser Ser Leu Gln Glu Leu Asp Le S er 210 215 220 ggc acc aac ctg gtg ccc ctg cct gag gcg ctg ctc ctc cac ctc ccg 721 Gly Thr Asn Leu Val Pro Leu Pro Glu Ala Leu Leu Leu His Leu Pro 225 230 235 240 gca ctg cag agc gtc gc cac gat gtg cgg tgc cgg cgc ctg 769 Ala Leu Gln Ser Val Ser Val Gly Gln Asp Val Arg Cys Arg Arg Leu 245 250 255 gtg cgg gag ggc acc tac ccc cgg agg cct ggc tcc agc ccc aag gtg 817 Val Arg Glu Gly Thr Pro Arg Arg Pro Gly Ser Ser Pro Lys Val 260 265 270 gcc ctg cac tgc gta gac acc cgg gaa tct gct gcc agg ggc ccc acc 865 Ala Leu His Cys Val Asp Thr Arg Glu Ser Ala Ala Arg Gly Pro Thr 275 280 285 atc ttg tgacaaatgg tgtggcccag ggccacataa cagactgctg tcctgggctg 921 Ile Leu 290 cctcaggtcc cgagtaactt atgttcaatg tgccaacacc agtggggagc ccgcaggcct 981 atgtggcagc gtcaccacag gagttgtggg cctaggagag gctttggacc tgggagccac 1041 acctaggagc aaagtctcac ccctttgtct acgttgcttc cccaaaccat gagcagaggg 1101 acttcgatgc caaaccagac tcgggtcccc tcctgcttcc cttccccact tatcccccaa 1161 gtgccttccc tcatgcctgg gccggcctga cccgcaat gg gcagagggtg ggtgggaccc 1221 cctgctgcag ggcagagttc aggtccactg ggctgagtgt ccccttgggc ccatggccca 1281 gtcactcagg ggcgagtttc ttttctaaca tagccctttc tttgccatga ggccatgagg 1341 cccgcttcat ccttttctat ttccctagaa ccttaatggt agaaggaatt gcaaagaatc 1401 aagtccaccc ttctcatgtg acagatgggg aaactgaggc cttgagaagg aaaaaggcta 1461 atctaagttc ctgcgggcag tggcatgact ggagcacagc ctcctgcctc ccagcccgga 1521 cccaatgcac tttcttgtct cctctaataa gccccaccct ccccgcctgg gctccccttg 1581 ctgcccttgc ctgttcccca ttagcacagg agtagcagca gcaggacagg caagagcctc 1641 acaagtggga ctctgggcct ctgaccagct gtgcggcatg ggctaagtca ctctgccctt 1701 cggagcctct ggaagcttag ggcacattgg ttccagccta gccagtttct caccctgggt 1761 tggggtcccc cagcatccag actggaaacc tacccatttt cccctgagca tcctctagat 1821 gctgccccaa ggagttgctg cagttctgga gcctcatctg gctgggatct ccaaggggcc 1881 tcctggattc agtccccact ggccctgagc acgacagccc ttcttaccct cccaggaatg 1941 ccgtgaaagg agacaaggtc tgcccgaccc atgtctatgc tctaccccca gggtagcatc 2001 tcagcttccg aaccctgggc tgtttcctta gtcttcattt tat aaaagtt gttgcctttt 2061 taacggagtg tcactttcaa ccggcctccc ctacccctgc tggccgggga tggagacatg 2121 tcatttgtaa aagcagaaaa aggttgcatt tgttcacttt tgtaatattg tcctgggcct 2181 gtgttggggt gttgggggaa gctgggcatc agtggccaca tgggcatcag gggctggccc 2241 cacagagacc ccacagggca gtgagctctg tcttccccca cctgcctagc ccatcatcta 2301 tctaaccggt ccttgattta ataaacacta taaaaagtt 2340 <210> 96 <211> 4694 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3600) .. (4499) <400> 96 ttcagggagt tttccctgag ttcggccata ggtaggtgcc tggaggactt ttcagagcag 60 tccaacggtc ttcagtgttt attgttaggt gtcatcactg gacactttgt gtgtgttaga 120 agtgtaagct gttctctctg acagaggagc aggtgaatgt atgtttaaaa acatttaaaa 180 acaattgatt attaataaca atcaattgaa cattgattgt tacggattca aatagttttg 240 attctagaaa ggactatgga ggtcttagaa aattaaactc ttcctttaca ggatggaaag 300 tatcatctag gaagaaagct agaaaggaaa gctttaagaa aaagcataaa agccatgtta 360 aagaggagaa cctaagctaa cagagcacga ggaagaaaaa attttgaatt caaaatcctg 420 agagatagtg attgaggtag tgatttccca taggtagaat gttggctcct aaagatgcct 480 acatcctaat ccccagaacc tgtgcagatg tccccttacg tggccagagg gacttgtagg 540 cgtgatgaag gctacagacc ttaaggtggg gagatcatga gtccttcact gcagcaggcc 600 ttttcttaac cgtgttaaag gtttaggttt gcccaagagg gccccacggc agcagtggac 660 aaatctccct tttccttttc ttctcagagc caactaaact gggctggggc aaagtgccct 720 gaattctttg agcagttggg aggtataggt ggggagtctg gggggatggg gagggacaga 780 gccaaacttt ctgaggtgaa atgttgggtg gggggctcac tgcttccttc tccttagatc 840 ctctcttctc t ctcaggacg gaatgctcgc cgattttctg caggccagtg ggaagcaaga 900 aggggctgga ggctgttcaa ctgctccgcc tcccttgact ggccccggat ggttgagtcc 960 tgcttgggct caccttgctg ggccagcccc caactccttc ggatgtaagt ctcttgaatt 1020 ccatccggta agagggtgag gcccttcaag cctcagggcc acactgccct agaatgactg 1080 agttagaagg gccctttggg gacagtctag cccagtctca ctcccactga cagatgggac 1140 aactgagtcc agagagggga ggggtagggt tttcttacct aagatcatac agcttaagac 1200 ctgactgaac tgagtccagt gtgggaatgg ataagacaat ccccctagag tgcttagcac 1260 agtggcctgc acagagtaag tgcacaataa atggtagctg ctgtttatta ttgaacccag 1320 gtcttctgac tccaagccca gtgctgtttc ctctattatc tttccaaagt atacctctga 1380 tagttgctta gcaaccttca gttgctccct attgccttcc tgttaagtct aggcttctta 1440 gcctgacatt caaagatctt tctgattctg gcccaactta ccatggtagc catacctcct 1500 gtgagtctcc tttaccctat ccaccctggg ttctatggtc aaactgaata ttgcactggt 1560 aaatacctgt ggttgtctcc ctttcctttt ctctgtcatt tcctgaccct gagccacttc 1620 cctcataatc atggaagcct ttagcgcctg attcccttct tgctttcttg agcaatatct 1680 gtttcatttg gatgactc at ctgacactct acagctcctc aactccagtg actttcattc 1740 tccactacac tcagcaaccc atttccatca ttcggagcta ttccacctct gaaagctcac 1800 atcccagcat cccactcggt gaccaccact tctcgtcctt ctagttctca cccttgcatc 1860 ccatgacatc tgctctttgc ctgcatccag atctccatcc ctccatttcc tgcatccctt 1920 gaccttgctt cctctctatc ctgtctgtgg ttgctcagtt cggccactca tcatcagcac 1980 cttcagcttt gcccatcctt tggccatatc tgacttgcaa acccctgagc tggaattgat 2040 cctccccatt ctgcttcccc tgctcctcag cccgggtagc tgagctctgc tggagaaaac 2100 cacatagccc tgcggattgc tgccactgca gagcccctcc ccctctccca tttcacccta 2160 gcttcctcga gcacatggag gcatccggca gggccccctc gacctgaggt ccagccctcg 2220 tgaactgatc tgcggctgca ctcaaccttc tcgccagtct caggatgagg tggccttgcc 2280 ccacctcaaa gcctgctcct ccacctgtgc tctggagcca cctctgccag catcgctggg 2340 gcctcacccc agcctctacc ttgctctgct ggctcttgct cttcaaccta ggaacgtgcc 2400 tgagcttttc tcatcttaaa caaaacaaca ataacagcaa cacaagcaaa atctcctttg 2460 accctgcatc cctctgttgg gttatcatca gcttatcatt cccacccttc ccatcaaaac 2520 atctcaaaag agtagtctac act caacact ctccatttcc tcactaccct cttactcctc 2580 aacctgctgc aatttgacat tcacccccag agttgctttg acctcctaat taccaaatca 2640 gtgggccctt gtcagtctct gtgtctgctg cattgatgct gtttaccacc ccctcctcaa 2700 aaaatgcctg tgcttattac tagttcctat aaagtgctga aacccaaatc tgtctagccc 2760 tggcccctcc cccaagattc agcctcctgt actcgactac atgtcagaca tctccccttg 2820 gatggcccac aggcacctta ctgtgaccaa aagagaattg gtcgtctcag tccccatctc 2880 aactctaaag tgatcttcct cctctgttcc ctatctcact tggtggcggc accatctacc 2940 ctgtcctgtt gactctcgaa tacttcccaa atctgaggtt ttgtgttgcc gtgtctactt 3000 cccttagtgt ctccttccct ctatcagact aagcttttca agggcaagga ctctacatca 3060 gctgtccgtg ccctagcaca ccacacaagt ctaggcacca aacaggcctc agtaaatgtc 3120 gttgaattga accgtgctct gctctctcat tcccagcagt gctgtccttg gtgggagctg 3180 acccagtgcc tggggaatga atgaagtggg agtctggatg ccaagaccct cttagtccct 3240 gatcccccta ttgagtccaa aagtctttct ttaaccctga tggcatttgg gacacagagg 3300 tatttgtaag gttttaaaag tggctttgta gacaaagtca gtcaaggcaa gacttccagg 3360 agttggaact gaacagccac attgccag at gtgtgctcca gactagaagt gatgtggatg 3420 ggtgggcaat tgggaggaga accaaaaggg cctggatgag tcagagtttc aagaggaggc 3480 atttgaacaa ttcaagcagg agaaagaata aagcaagttt caaagtccag aaggaacatg 3540 gcatgtgtat ataatgggag ggagggagtg acaagagcag catggagagg tttggatag 3599 gtg gcc ttc aag gta ctt tcc aat cct aag tgc ctg cag agt gga agc 3647 Val Ala Phe Lys Val Leu Ser Asn Pro Lys Cys Leu Gln Ser Gly Ser 1 5 10 15 tgc tgg tct cgg aga agt ctg gac cac aga gat ctt ctc cca acc caa 3695 Cys Trp Ser Arg Arg Ser Leu Asp His Arg Asp Leu Leu Pro Thr Gln 20 25 30 gca tac cag agg gat gcg aca cat gcc ggc agt aac agc ggc tca ctt 3743 Ala Tyr Gln Arg Asp Ala Thr His Ala Gly Ser Asn Ser Gly Ser Leu 35 40 45 ggc atc ttc aaa gcc atg ggg cag ggc ctg cca gac gag cag gag 3791 Gly Ile Phe Lys Ala Met Gly Gln Gly Leu Pro Asp Glu Glu Gln Glu 50 55 60 aag ctg ctg cgc atc tgt tcc att tat acc cag agt gga gaa aac agc 3839 Lys Leu Leu Arg Ile Cys Ser Ile Tyr Thr Gln Ser Gly Glu Asn Ser 65 70 75 80 ctg gtg cag gag ggc tct gag gcc t cc ccc att ggg aag tct cca tat 3887 Leu Val Gln Glu Gly Ser Glu Ala Ser Pro Ile Gly Lys Ser Pro Tyr 85 90 95 aca cta gac agc ctg tat tgg agc gtc aag cca gcc agc tcc agc ttc 3935 Thr Leu Asp Ser Leu Tyr Trp Ser Val Lys Pro Ala Ser Ser Ser Phe 100 105 110 ggg tct gaa gca aag gcc cag caa cag gag gag cag ggc agt gtt aat 3983 Gly Ser Glu Ala Lys Ala Gln Gln Gln Glu Glu Gln Gly Ser Val Asn 115 120 125 gat gtc aag gaa gag gag aag gag gag aaa gag gtc ttg cca gac cag 4031 Asp Val Lys Glu Glu Glu Lys Glu Glu Lys Glu Val Leu Pro Asp Gln 130 135 140 gta gag gag gag gaa gaa aat gat gag gag caa gag gag gag gat 4079 Val Glu Glu Glu Glu Glu Asn Asp Asp Gln Glu Glu Glu Glu Glu Asp 145 150 155 160 gaa gat gat gaa gat gat gaa gag gaa gac aga atg gag gtg ggg cct 4127 Glu Asp Asp Glu Asp Asp Glu Glu Arg Met Glu Val Gly Pro 165 170 175 ttc tct aca ggg caa gag tcc ccc act gcc gag aat gct agg ctt ctg 4175 Phe Ser Thr Gly Gln Glu Ser Pro Thr Ala Glu Asn Ala Arg Leu Leu 180 185 190 gcc cag aaa aga gga gct ttg cag ggc tct gca tgg cag gtt agc tca 4223 Ala Gln Lys Arg Gly Ala Leu Gln Gly Ser Ala Trp Gln Val Ser Ser 195 200 205 gaa gac gtg cga tgg gac aca ttt ccc cta ggc cga atg cca glu gag 4271 Asp Val Arg Trp Asp Thr Phe Pro Leu Gly Arg Met Pro Gly Gln 210 215 220 acc gag gac cca gca gag ctc atg ctg gag aat tat gac acc atg tat 4319 Thr Glu Asp Pro Ala Glu Leu Met Leu Glu Asn Tyr Asp Thr Met Tyr 225 230 235 240 ctt ttg gac cag cct gtg cta gag cag cgg ctg gaa ccc tca aca tgc 4367 Leu Leu Asp Gln Pro Val Leu Glu Gln Arg Leu Glu Pro Ser Thr Cys 245 250 255 aag act gac acc ttg ggc ctg agc gt ggt gtc ggc agt ggc aac tgc 4415 Lys Thr Asp Thr Leu Gly Leu Ser Cys Gly Val Gly Ser Gly Asn Cys 260 265 270 agc aac agc agc agc agc aac ttc gag ggc ctt ctc tgg agc cag ggg Ser Ser Sern Asn Phe Glu Gly Leu Leu Trp Ser Gln Gly 275 280 285 cag ctg cat ggg ctc aaa act ggc ctg cag ctc ttc tgatggccat 4509 Gln Leu His Gly Leu Lys Thr Gly Leu Gln Leu Phe 290 295 300 ccctggtgcagt atc cagccgtgcc agggcaacag cccaccccct agtacaactg 4569 atgctccctg agacaacctg ggagacagcc tggatcagcc acatcaactc agttgtccac 4629 cacaggggaa ttttgaatgt cttttgtttt tgttttgttt tgaaaaataa taagtaggca 4689 <210> 97 <211> 4191 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (109) .. (1536) <400> 97 gtggggaagc tgctaacccg acccggattg gcgctgaggt ggcccgtggg gcagggcaga 60 tgattctgga ccagatgaag cctgaggagc cttccagctc taagatag cag gat agg 117 Gln Asp Arg 1 aga cg c ag ct gag cag cag ct gag cag cg Thr Cys Gln Pro Thr Ser Thr 5 10 15 atg tca gga agc cat aca cct gcc tgt ggc cct ttc tca gcc ctg act 213 Met Ser Gly Ser His Thr Pro Ala Cys Gly Pro Phe Ser Ala Leu Thr 20 25 30 35 ccg agc ata tgg ccc cag gag atc ttg gcc aag tac acg cag aag gaa 261 Pro Ser Ile Trp Pro Gln Glu Ile Leu Ala Lys Tyr Thr Gln Lys Glu 40 45 50 gag tca gca gag caa cca gag ttc tac tac gat gag ttt ggt ttc cgt 309 Glu Ser Ala Glu Gln Pro Glu Phe Tyr Tyr Asp Glu Phe Gly Phe Arg 55 60 65 gtg tac aag gaa gaa ggt gat gag cct ggc tcc agt ctg ctg gcg aac 357 Val Tyr Lys Glu Glu Gly Asp Glu Pro Gly Ser Seru Le Ala Asn 70 75 80 tcc cct ctg atg gag gat gct cca cag agg ctg cgg tgg cag gcc cac 405 Ser Pro Leu Met Glu Asp Ala Pro Gln Arg Leu Arg Trp Gln Ala His 85 90 95 ctg gag ttc acc cat aac cac gat gtg ggg gat ctc acc tgg gac aag 453 Leu Glu Phe Thr His Asn His Asp Val Gly Asp Leu Thr Trp Asp Lys 100 105 110 115 att gcc gtc tcc cta ccc cgc tct gag aag ctc cgc tcc ctg gtg ctg 501 Ile Ala Val Ser Leu Pro Arg Ser Glu Lys Leu Arg Ser Leu Val Leu 120 125 130 gcc ggc atc cca cat ggc atg agg cca cag ctg tgg atg cgg ctc tct 549 Ala Gly Ile Pro His Gly Met Arg Pro Gln Leu Trp Met Arg Leu Ser 135 140 145 ggg gcc ctg cag aag aag agg aac tct gag ctg tcc tac cgc gag att 597 Gly Ala Leu Gln Lys Lys Arg Asn Ser Glu Leu Ser Tyr Arg Glu Ile 150 155 160 gtg aag aac agc tcc aac gat gag acc atc gct gcc aag cag atc gag 645 Val Lys Asn Ser Ser Asn Asp Glu Thr Ile Ala Ala Lys Gln Ile Glu 165 170 175 aag gac ctg ctc cgc acc atg ccc agc aac gcc tgc ttc gg ag 693 Lys Asp Leu Leu Arg Thr Met Pro Ser Asn Ala Cys Phe Ala Ser Met 180 185 190 195 ggt agc atc ggg gtg ccc cgc ctg cgc agg gtg ctc cgg gcc ctg gcc 741 Gly Ser Ile Gly Val Pro Arg Leu Arg Arg Valu Le Ar g Ala Leu Ala 200 205 210 tgg ctc tac cca gag atc ggc tac tgc cag ggc acc ggc atg gtg gcc 789 Trp Leu Tyr Pro Glu Ile Gly Tyr Cys Gln Gly Thr Gly Met Val Ala 215 220 225 gcc tgc ctc ctg ctg gag gag gag gac gcc ttc tgg atg atg 837 Ala Cys Leu Leu Leu Phe Leu Glu Glu Glu Asp Ala Phe Trp Met Met 230 235 240 tct gcc atc atc gag gac ctg ctc ccc gcc tcc tac ttc agc acc acc Ile Ser Ala Glu Asp Leu Leu Pro Ala Ser Tyr Phe Ser Thr Thr 245 250 255 ctg ctg ggt gtc cag act gac cag cgg gtc ctg cgc cac ctc att gtc 933 Leu Leu Gly Val Gln Thr Asp Gln Arg Val Leu Arg His Leu Ile Val 260 265 270 275 cag tac ctg cct cgc ctg gac aag ctg ctc cag gag cat gac att gag 981 Gln Tyr Leu Pro Arg Leu Asp Lys Leu Leu Gln Glu His Asp Ile Glu 280 285 290 ctg tcc ctg atc aca ctg cac tgg ttc gcc agc gtg 1029 Leu Ser Leu Ile Thr Leu His Trp Phe Leu Thr Ala Phe Ala Ser Val 295 300 305 gtg gac atc aag ctg ctc ctg cgc atc tgg gac ctg ttt ttc tac gag 1077 Val Asp Ile Lys Leu Leu LeuTrp Asp Leu Phe Phe Tyr Glu 310 315 320 ggc tcc cgg gtg ctg ttc cag ctc acg ctg ggc atg ctg cac ctc aag 1125 Gly Ser Arg Val Leu Phe Gln Leu Thr Leu Gly Met Leu His Leu Lys 325 330 335 gag ga atc cag tca gag aac tcg gcc tcc atc ttc aac acg 1173 Glu Glu Glu Leu Ile Gln Ser Glu Asn Ser Ala Ser Ile Phe Asn Thr 340 345 350 355 cta tcg gat atc ccg tcg cag atg gag gac gcg gag ctg ctt ctg gtt1 Leu Ser Asp Ile Pro Ser Gln Met Glu Asp Ala Glu Leu Leu Leu Gly 360 365 370 gtg gcc atg cgg ctg gcc ggc tcc ctc acc gat gtg gcc gtg gag act 1269 Val Ala Met Arg Leu Ala Gly Ser Leu Thr Asp Val Ala Val Glu Thr 375 380 385 cag cgc cgc aag cac ctg gcc tat ctc att gca gac cag ggc cag ctc 1317 Gln Arg Arg Lys His Leu Ala Tyr Leu Ile Ala Asp Gln Gly Gln Leu 390 395 400 ctg ggg gcc ccc acc ccc accc tct cag gtg gcc cag gat ggg 1365 Leu Gly Ala Gly Thr Leu Thr Asn Leu Ser Gln Val Ala Gln Asp Gly 405 410 415 ggg ccg cac ctt gac cca cag cac acg ggg agg agg ggt cac ctt gaa 1413 Gly Pro His Leu Asp Pro Gln His Thr Gly Arg Arg Gly His Leu Glu 420 425 430 435 gtt cag agc gcg ggg gct gcg gaa aac aaa cca gcc ctt cct gct ctg 1461 Val Gln Ser Ala Gly Ala Ala Glu Asn Lys Pro Ala Leu Pro Ala Leu 440 445 450 ccc ccc agc ctg gcc cag tca gac cac agc tgt ggg gtg atc cag gcc 1509 Pro Pro Ser Leu Ala Gln Ser Asp His Ser Cys Gly Val Ile Gln Ala 455 460 465 tcc tca ggc ttt gtg cac ctc agg ttc tgatcc tgg Ser Ser Gly Phe Val His Leu Arg Phe 470 475 aggaaggcag acccagctct gattatctgt tttcaattct tggagccagc gtcagaggct 1616 atttcagatg agacagtata agccaagggc tggtgggttc tcttcctccc ggggccagga 1676 ccaccctgac ccactcctct tggtgcaggt tgttcgccgc aggacccagc ggaggaagtc 1736 caccatcact gctctgctct tcggggagga tgacctggag gcactcaagg ccaagaacat 1796 caagcagacg gaactggtgg ctgacctccg ggaagccatc ctgcgcgtgg cacgccactt 1856 ccagtgcaca gaccccaaaa actgcagcgt ggtgagtcgc cagctccctg ggctgctacc 1916 aaacacggcc ctaactcctc caaccccctt ggtgggcctg tgttcactgt ggcaggagct 1976 gactccagac tatagcatgg agagccacca gcgggacc ac gagaactacg tggcgtgctc 2036 acgcagccac cggcgccgag ccaaggccct gctggacttt gagcggcacg acgacgacga 2096 gctgggcttc cgcaagaacg acatcatcac agtgcgtggg ggcgctggac taccaggtcc 2156 tcaggctgtg gcgggttccc cagactccct ccaccaagcc ccaccccaac ccctttccct 2216 gccaagagct tctcttgtga agatgtaggg gtcttggcct ggcctagttg ctgaggagtc 2276 atatcggggg tgcaggaggc gctggcccag ggcacccagc tttggttcct gctgtttttc 2336 ctcctgtgca gatcgtgtct cagaaggacg agcactgctg ggtgggggag ctcaacggcc 2396 tgcgaggtgg ggtccttggt ctgctcttga gctgggagag ggaggagggg gtgggcacag 2456 aagacttggg tgaccctggc cgccaccaag ctgttctcct ctatacacct gcctggcttg 2516 aggtccctga agcagctgag ccggcttccc actgcctcag cctgcctgca ggctgtgtct 2576 gctctgtcct cggccctcgt ggttgctcct tacagggcct gtttttccca caggctggtt 2636 tccagccaag ttcgtggaag tcctggatga gcgcagcaaa gaggtgaggg gggtgggcgg 2696 gctaggcacg gctggcaccc ttctagccag ggcctgcgtg cctagcgagt cctggcctgt 2756 agcatggcag agaggacaga ggagggtgac tggctgcagg cgtcaggcag ggctttctca 2816 gacccatccc tcccatcagt actccatcgc gggggatgac tcg gtgacgg agggggtcac 2876 agacctcgtg cgagggaccc tctgcccggc ccttaaggcc ctgttcgaac atggactgaa 2936 gaagccatcc ctgcttgggg gcgcctgcca cccctggctg tttatcgagg aggctgcagg 2996 ccgggaggtc gagagagact ttgcctccgt gtattcccgt ctggtgctct gtaagacctt 3056 caggttggat gaagatggca aagtcctgac cccggaggag ctgctctacc gggctgtgca 3116 gtctgtgaac gtgacccacg atgcagtgca tgcacaaatg gatgtgaagc tccgctcact 3176 gatctgcgtg gggctcaagt gagtgtggaa aaggggttgg aggagagccc tggagtgggg 3236 ggacccagcc cagcatcagg gggggtcctt acagggaacc ctaaaggaca aagaacctca 3296 ggggctcagg tccttcccca aagagggtgg tctgggagct gctgagagac aggtcagagg 3356 cttccaccgt ggctgcagcc agaagggcct ggagctgccc ctgctcccca ctcctggcca 3416 tgtccccagt gagcaggtgc tgcacctgtg gctggaggtg ctctgctcca gcctgcccac 3476 cgtggagaag tggtaccagc cctggtcctt cctgcgcagc ccgggctggg tccagatcaa 3536 gtgtgagctc cgagtcctct gctgctttgc cttcagcctc tcccaggact gggagctccc 3596 tgcgaagaga gaggtgggtg gtgtgggcct cgtagggcct gcactgatgg aggtgcccaa 3656 accgttcgcg gggtggctaa ggtgggaacc cgaagtgctg gtgtcagc gg ttaggaacta 3716 ccccagccat gcccaaggcc tgtgaggtga ggggctgccc tgtttgcagg cgcagcagcc 3776 cctgaaggag ggcgtccggg acatgctggt gaagcaccac ctcttcagct gggatgtgga 3836 cgggtgaccc cctcctcccc agcccaacct cgggcctgcg tctgaggtgg cccaggaccc 3896 caagctgcag agcccaggga agagcagctc cagagccctg gccggggccg cgggatatca 3956 atatcaggct gccccactcc acgttcccca gcacatccca ggtggtggga gcagagggta 4016 ccctgcccca ccagggtcct tagggatgct ctaggccaaa ccacagtttg taccaaaaac 4076 cttgtgagga ggtgggggag ccatgtctgt gctcaggaag agggaagggg atgggggtgg 4136 ctagtaggct cctggcctct ttggtttata aataaactgt gtctgtctgt ctttg 4191 <210> 98 <211> 4042 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3694) <400> 98 g tgc cca tgg aag gga caa ggc tct cgt gca gag agt cca tgg aag gga 49 Cys Pro Trp Lys Gly Gln Gly Ser Arg Ala Glu Ser Pro Trp Lys Gly 1 5 10 15 caa ggc tct ctg tac gag tgc ccc cac atc ccc acc cct gtg tgc att 97 Gln Gly Ser Leu Tyr Glu Cys Pro His Ile Pro Thr Pro Val Cys Ile 20 25 30 ggg cac cgg gat gca ccc tcc ttc tca tcc cca cca cgc cag gct cct 145 Gly His Arg Asp Ala Pro Ser Phe Ser Ser Pro Pro Arg Gln Ala Pro 35 40 45 gag cca tcc ctc ttc ttc cag gat ccc cct gga act agt atg gag agc 193 Glu Pro Ser Leu Phe Phe Gln Asp Pro Pro Gly Thr Ser Met Glu Ser 50 55 60 ctg gcc ccc tcc act gac tct ctg cat ggc tcc cca gtg ctg atc ccc 241 Leu Ala Pro Ser Thr Asp Ser Leu His Gly Ser Pro Val Leu Ile Pro 65 70 75 80 caa gtg tgc atc ggg cac cgg gat gca ccc cga gcc tcc tcc cca ccc 289 Gln Val Cys Ile Gly His Arg Asp Ala Pro Arg Ala Ser Ser Pro Pro 85 90 95 cgc cac cca ccc agt gac cta gcg ttc ctg gca ccc tca cct tca ccg 337 Arg His Pro Pro Ser Asp Leu Ala Phe Leu Ala Pro Ser Pro Ser Pro 100 105 110 ggc agc tct ggg ggc tcc cgg ggc tca gcg cct ccc ggg gag acc agg 385 Gly Ser Ser Gly Gly Ser Arg Gly Ser Ala Pro Pro Gly Glu Thr Arg 115 120 125 cac aac ttg gag cgg gag gag tac act gtg ctg gcc gac ctg ccc cca 433 His Asn Leu Glu Arg Glu Glu Tyr Thr Val Leu Ala Asp Leu Pro 130 135 140 ccc agg agg ctg gcc cag aga cag cca ggg ccc cag gcg cag tgc agc 481 Pro Arg Arg Leu Ala Gln Arg Gln Pro Gly Pro Gln Ala Gln Cys Ser 145 150 155 160 agc ggg ggc cgc acc cgc agc cct ggc cgt gca gag gtg gag cgc ctc 529 Ser Gly Gly Arg Thr Arg Ser Pro Gly Arg Ala Glu Val Glu Arg Leu 165 170 170 175 ttc ggg cag cgc agg aag tcc gag gca gcg ggg gcc ttc cag gcc 577 Phe Gly Gln Glu Arg Arg Lys Ser Glu Ala Ala Gly Ala Phe Gln Ala 180 185 190 cag gac gag gga cgg tca cag cag ccc agc caa ggc cag agcca cca Asp Glu Gly Arg Ser Gln Gln Pro Ser Gln Gly Gln Ser Gln Leu 195 200 205 ctc cga aga cag tcc agc cct gcc ccc agc agg cag gtg acc atg ctc 673 Leu Arg Arg Gln Ser Ser Pro Ala Pro Ser Arg Gln Val Thr MetLeu 210 215 220 cct gcc aaa cag gca gaa ctg acc cgg cgg agc caa gca gat ccc cct 721 Pro Ala Lys Gln Ala Glu Leu Thr Arg Arg Ser Gln Ala Asp Pro Pro 225 230 235 240 cat cct cgg agt cct gag aag aga cct gag gga gat cgg cag ctc cag 769 His Pro Arg Ser Pro Glu Lys Arg Pro Glu Gly Asp Arg Gln Leu Gln 245 250 255 ggg tcc ccg ctg ccc ccc agg aca tca gcc agg acc cct gag agg gag 817 Gly Ser Pro Leu Pro Pro Arg Thr Ser Ala Arg Thr Pro Glu Arg Glu 260 265 270 270 ctg cgg aca cag aga cct ctg gag agt ggc caa gca ggc cca aga cag 865 Leu Arg Thr Gln Arg Pro Leu Glu Ser Gly Gln Ala Gly Pro Arg Gln 275 280 285 cct ctg ggg gtg tgg cag agt cag gag gaa ccg cca ggg tcc cag ggc 913 Pro Leu Gly Val Trp Gln Ser Gln Glu Glu Pro Pro Gly Ser Gln Gly 290 295 300 cct cat aga cac cta gaa agg agc tgg agc agc gag gag gag ctg 961 Pro His Arg His Leu Glu Arg Ser Trp Ser Ser Gln Glu Gly Gly Leu 305 310 315 320 ggc cct ggg ggc tgg tgg gga tgt gga gag ccc agc ctg ggg gca gcc 1009 Gly Pro Gly Gly Trp Trp Gly Cys Gly Glu Plu ro Ser Leu Gly Ala Ala 325 330 335 aaa gcc ccg gag gga gca tgg ggg ggc act tcc agg gag tac aag gag 1057 Lys Ala Pro Glu Gly Ala Trp Gly Gly Thr Ser Arg Glu Tyr Lys Glu 340 345 350 agc tgg ggg cag cca gag gcc tgg gag gag aag ccc act cat gag ctc 1105 Ser Trp Gly Gln Pro Glu Ala Trp Glu Glu Lys Pro Thr His Glu Leu 355 360 365 ccc aga gaa cta gga aag aga agc cca ctc acg agc ccc cct gag aac 1153 Pro Arg Glu Leu Gly Lys Arg Ser Pro Leu Thr Ser Pro Pro Glu Asn 370 375 380 tgg gga ggc ccc gca gag tcc tca caa tcc tgg cac tct ggg aca ccc 1201 Trp Gly Gly Pro Ala Glu Ser Ser Gln Ser Trp His Ser Gly Thr Pro 385 390 395 400 act gct gtg ggc tgg ggg gca gag gga gcg tgt cca tac ccg cgt ggc 1249 Thr Ala Val Gly Trp Gly Ala Glu Gly Ala Cys Pro Tyr Pro Arg Gly 405 410 415 tct gag agg cga ccc gag ctt gac tgg gat ctg ctt ggc ctt ctc 1297 Ser Glu Arg Arg Pro Glu Leu Asp Trp Arg Asp Leu Leu Gly Leu Leu 420 425 430 cgg gca cca gga gag ggg gtc tgg gcc cgt gtc ccc agc ctg gac tgg 1345 Arg Ala Pro Gly y Val Trp Ala Arg Val Pro Ser Leu Asp Trp 435 440 445 gag ggc ctc ttg gag ctc ctg cag gcc agg ctg ccc cgc aag gac cca 1393 Glu Gly Leu Leu Glu Leu Leu Gln Ala Arg Leu Pro Arg Lys Asp Pro 450 455 gct gga cac agg gat gac ctg gcc agg gct tta ggg cca gag ctg ggt 1441 Ala Gly His Arg Asp Asp Leu Ala Arg Ala Leu Gly Pro Glu Leu Gly 465 470 475 475 480 ccc cca ggc aca aac gat gtc cct gca cagag agc cag cca 1489 Pro Pro Gly Thr Asn Asp Val Pro Glu Gln Glu Ser His Ser Gln Pro 485 490 495 gaa ggc tgg gcc gag gcc acc cca gtc aat gga cac agc ccc gca ctg 1537 Glu Gly Trp Ala Glu Ala Thr Pro Val Asn Gly His Ser Pro Ala Leu 500 505 510 cag tcc cag agc ccg gtc cag ctg ccc agc cct gcc tgc acc tcc acc 1585 Gln Ser Gln Ser Pro Val Gln Leu Pro Ser Pro Ala Cys Thr Ser Thr 515 520 525 cag tgg cca aag atc aaa gtg aca aga gga cca gcg acc gca act ctg 1633 Gln Trp Pro Lys Ile Lys Val Thr Arg Gly Pro Ala Thr Ala Thr Leu 530 535 540 gca ggc ctg gag cag acg ggc ccc ctg ggg agc agg agc act gcg aag 1681 Gly Leu Glu Gln Thr Gly Pro Leu Gly Ser Arg Ser Thr Ala Lys 545 550 555 560 ggc ccc agc ttg cca gag ctg cag ttc caa cca gag gag cct gag gag 1729 Gly Pro Ser Leu Pro Glu Leu Gln Phe Gln Pro Glu Glu Pro Glu Glu 565 570 575 tca gaa cca agc aga ggc caa gac ccc ctg act gac cag aag cag gca 1777 Ser Glu Pro Ser Arg Gly Gln Asp Pro Leu Thr Asp Gln Lys Gln Ala 580 585 590 gac tcg gca gac aag agg cca gg ggc aag gct ggg agc ccg ctc 1825 Asp Ser Ala Asp Lys Arg Pro Ala Glu Gly Lys Ala Gly Ser Pro Leu 595 600 605 aag ggc cga ctg gtg acc tca tgg cgg atg ccc ggg gac cgg ccc acg 1873 Lys Gly Arg Leu Val Ser Trp Arg Met Pro Gly Asp Arg Pro Thr 610 615 620 ctg ttc aat ccg ttc ctg ctg tct ctg ggg gtc ctc agg tgg cga agg 1921 Leu Phe Asn Pro Phe Leu Leu Ser Leu Gly Val Leu Arg Trp Arg 630 630 ccc gat ctg ctc aac ttc aag aag gga tgg atg tcg atc ttg gac gag 1969 Pro Asp Leu Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu 645 650 655 655 cct gga gag cct ccc tcc ccc tcg ccc acc tct act tcg cag 2017 Pro Gly Glu Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln 660 665 670 tgg aag aaa cat tgg ttt gtg ctg aca gat tca agt ctc aaa tat tac 2065 Trp Lys Lys His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr 675 680 685 aga gac tcc act gct gag gag gca gat gag ctg gat ggt gag atc gac 2113 Arg Asp Ser Thr Ala Glu Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp 690 695 700 ctg cgt tcc tgc acg gat gtc act gag tac gcg gtg cag cgc aac tat 2161 Leu Arg Ser Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr 705 710 710 715 720 ggc ttc cag atc cac acc aag gat gct gtc tat acc ttg tcg gat atc Gly Phe Gln Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met 725 730 735 acc tca ggc atc cgg cgg aac tgg atc gag gct ctg aga aag acc gta 2257 Thr Ser Gly Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val 740 745 750 cgt cca act tca gcc cca gat gtc acc aag ctc tcg gac tct aac aag 2305 Arg Pro Thr Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys 755 760 765 gag aac gcg ctg cac agc tac a gc acc cag aag ggc ccc ctg aag gca 2353 Glu Asn Ala Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala 770 775 780 ggg gag cag cgg gcg ggc tct gag gtc atc agc cgg ggt ggc cct cgg 2401 Gly Glu Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg 785 790 795 800 aag gcg gac ggg cag cgt cag gcc ttg gac tac gtg gag ctc tcg ccg 2449 Lys Ala Asp Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro 805 810 815 ctg acc cag gct tcc ccg cag cgg gcc cgc acc cca gcc cgc act cct 2497 Leu Thr Gln Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro 820 825 830 gac cgc ctg gcc aag cag gag gag ctg gag cgg gac ctg gcc cag cgc 2545 Asp Arg Leu Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg 835 840 845 tcc gag gag cgg cgc aag tgg ttt gag gcc aca gac agc agg acc cca 2593 Ser Glu Glu Arg Arg Lys Trp Ala Thr Asp Ser Arg Thr Pro 850 855 860 gag gtg cct gct ggt gag ggg ccg cgc cgg ggc ctg ggt gcc ccc ctg 2641 Glu Val Pro Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu 865 870 870 875 880 880 act gag gac cag caa aac cgg ctt agt gag gag atc gag aag aag tgg 2689 Thr Glu Asp Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp 885 890 895 cag gag ctg gag aag ctg ccc ctg cgg gag aat cag ggg ctc 2737 Gln Glu Leu Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu 900 905 910 act gcc ctg ctc aac caa agc cgc gga gag cgc cga ggg ccc cca agt 2785 Thr Ala Leu Leu Asn Gln Ser Arg Gly Glu Arg Gly Pro Pro Ser 915 920 925 gac ggc cac gag gca ctg gag aag gag gtt cag gct ctt cgg gcc cag 2833 Asp Gly His Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln 930 935 940 ctg gag gcg tgg cgtct ggg gag gct cct cag agt gca ctg aga 2881 Leu Glu Ala Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg 945 950 955 960 tcc cag gag gat ggc cac atc ccc ccg ggc tac atc tca cag gag Gca 2929 Ser Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Glu Ala 965 970 975 tgt gag cgc agc ctg gca gag atg gag tcc tcg cac cag cag gtg atg 2977 Cys Glu Arg Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln Val M et 980 985 990 gag gag ctg cag cgg cac cac gag cgg gag ctg cag cgc ctg cag cag 3025 Glu Glu Leu Gln Arg His His Glu Arg Glu Leu Gln Arg Leu Gln Gln 995 1000 1005 gag aag gag tgg ctc gggg gg gca gcc acg gcc tca gcc 3073 Glu Lys Glu Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala Ser Ala 1010 1015 1020 att gaa gcc atg aag aag gcc tat cag gaa gag ctg agc cga gag ctg 3121 Ile Glu Ala Met Lys Tyr Gln Glu Glu Leu Ser Arg Glu Leu 1025 1030 1035 1040 agc aaa aca cgg agt ctc cag cag ggc ccg gat ggc ctc cgg aag cag 3169 Ser Lys Thr Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg Lys Gln 1045 1050 cag tca gat gtg gag gca ctg aag cga gag ctg cag gtg cta tcg 3217 His Gln Ser Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val Leu Ser 1060 1065 1070 gag cag tac tcg cag aag tgc ctg gag att ggg gca cag 3265 Glu Gln Tyr Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met Arg Gln 1075 1080 1085 gct gag gag cgc gag cac acg ctg cgc cgc tgc cag cag gag ggc cag 3313 Ala Glu Glu Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu Gly Gln 1090 1095 1100 gag ctg ctg cgc cac aac cag gag ctg cat ggc cgc ctg tca gag gag 3361 Glu Leu Leu Arg His Asn Gln Glu Leu His Gly Arg Leu Ser Glu 1120 11 ata gac cag ctg cgc ggc ttc att gcc tcg cag ggc atg ggc aat ggc 3409 Ile Asp Gln Leu Arg Gly Phe Ile Ala Ser Gln Gly Met Gly Asn Gly 1125 1130 1135 tgc ggg cgc agc ag gag cgg ag gag cgg ctg ctt 3457 Cys Gly Arg Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val Leu Leu 1140 1145 1150 cgc gta aaa gaa aac gaa ctc cag tac cta aag aag gag gtg cag tgc 3505 Arg Val Lys Glu Asn Glu Leu Gyr Tyr Lys Glu Val Gln Cys 1155 1160 1165 ctc cgg gac gag ctc cag atg atg cag aag gac aag cgc ttc acc tcg 3553 Leu Arg Asp Glu Leu Gln Met Met Gln Lys Asp Lys Arg Phe Thr Ser 1170 1175 1180 gga aag tac g tat gtg gag ctg agc cac atc aag aca cgg 3601 Gly Lys Tyr Gln Asp Val Tyr Val Glu Leu Ser His Ile Lys Thr Arg 1185 1190 1195 1200 tct gag cgg gag atc gag cag ctg aag gag cac ctg cgt ctt gcc atg 3649 Ser Glu Arg Glu Ile Glu Gln Leu Lys Glu His Leu Arg Leu Ala Met 1205 1210 1215 gcc gcc ctc cag gag aag gag tcg atg cgc aac agc ctg gct gag 3694 Ala Ala Leu Gln Glu Lys Glu Asn Ser Leu Ala Glu 1220 1225 1230 tagaggtccc gcccagctgc agaccctcca ggctggagga ccagccgccc tccttccctc 3754 ctggatggaa gtaaaaagcc aagctttctc cccaccctct gtgggccaca cgtgcacttg 3814 cacccaccac acacacacac acacacacac acacacagac acacagacac atacgcacac 3874 acgtgcacac atgtacacac ggatacacac acacacacac acacacacac tgcatatctg 3934 agcgcgcccc tcgcactggg tctcaccttg caccttcttc aggattttat atgtgaagag 3994 atttttatat agattttttt cctttttttc caaaacactt tatacttt 4042 <210> 99 <211> 4978 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2879) <400> 99 ag acg atg tcg ctc tca gac aag cag aca gcc tct ctc act gcc gcg 47 Thr Met Ser Leu Ser Asp Lys Gln Thr Ala Ser Leu Thr Ala Ala 1 5 10 15 tac ggt cag ctc agt aag ggc aag cct gca gag tgc cga atg gac tcc 95 Tyr Gly Gln Leu Ser Lys Gly Lys Pro Ala Glu Cys Arg Met Asp Ser 20 25 30 cca aaa gaa atc agt caa gcc gga ttc gaa tgg cag agg aca gag ggc 143 Pro Lys Glu Ile Ser Gln Ala Gly Phe Glu Trp Gln Arg Thr Glu Gly 35 40 45 aaa ctg aat gaa att ggg ctg aat gtc agc atg gac ggg caa cca aaa 191 Lys Leu Asn Glu Ile Gly Leu Asn Val Ser Met Asp Gly Gln Pro Lys 50 55 60 gat ggg ctt gtg aag aat gcc agc ttc ctg gag cag aac aag ctc tgc 239 Asp Gly Leu Val Lys Asn Ala Ser Phe Leu Glu Gln Asn Lys Leu Cys 65 70 75 ttt ttt gag ggg aag cta gac aaa gag ctg agc att gac attga 287 Phe Phe Glu Gly Lys Leu Asp Lys Glu Leu Ser Ile Glu Met Gln Asp 80 85 90 95 aag gac tgt caa gaa gcc tca ggt cac ctt gag agc agg tat gtg att 335 Lys Asp Cys Gln Glu Ala Ser Gly His Leu Glu Ser Arg Tyr Val Ile 100 105 110 tca gag acc tgc cat ccc ttg gag ggg aac tcg gta cac cag aag acc 383 Ser Glu Thr Cys His Pro Leu Glu Gly Asn Ser Val His Gln Lys Thr 115 120 125 tcc gag ttc cat ctg gga ctc ata gag ggg cca gac aaa aac aaa acc 431 Ser Glu Phe His Leu Gly Leu Ile Glu Gly Pro Asp Lys Asn Lys Thr 130 135 140 att cca gtt cag ggg aag gtg gca ggg aag aat gga cta gag acc aag 479 Ile Pro Val Gln Gly Lys Val Ala Gly Lys Asn Gly Leu Glu Thr Lys 145 150 155 agc cag tca gat ctg gat ttc cct ggg gct gct gac atc cct acc aga 527 Ser Gln Ser Asp Leu Asp Phe Pro Gly Ala Ala Asp Ile Pro Thr Arg 160 165 170 175 tat gtt aag gag cag gaa acc agt gtt tgg aac ccc agc ttt cat cca 575 Tyr Val Lys Glu Gln Glu Thr Ser Val Trp Asn Pro Ser Phe His Pro 180 185 190 gtg gct caa ggc tct ctg ggc tca agg gaa gca act ccg gga gag atg 623 Val Ala Gln Gly Ser Leu Gly Ser Arg Glu Ala Thr Pro Gly Glu Met 195 200 205 gag aat agc atc acc cct ggc tgc cca gtg att ggg gtg gta aat gat 671 Glu Asn Ser Ile Thr Pro Gly Cys Pro Val Ile Gly Val Val Asn Asp 21 0 215 220 aac tct gag cag ctg aag tgt gag tcc cca ctc ctg gtg tct cta gcc 719 Asn Ser Glu Gln Leu Lys Cys Glu Ser Pro Leu Leu Leu Val Ser Leu Ala 225 230 235 cac cca gcc ccc att att gag cat tca ccc acc acc att ccg cca atc 767 His Pro Ala Pro Ile Ile Glu His Ser Pro Thr Thr Ile Pro Pro Ile 240 245 250 255 act atg gtg ttc acc cag gaa cat ttg aat gca agc tgt cac atc aga 815 Thr Met Val Phe Thr Gln Glu His Leu Asn Ala Ser Cys His Ile Arg 260 265 270 gac cat gat aag gag ttg gag aaa ttg agt tct acc gag gag gct gtg 863 Asp His Asp Lys Glu Leu Glu Lys Leu Ser Ser Thr Glu Glu Ala Val 275 280 285 285 ctc aac caa gcc ccc cag cag aaa aag gca gtg cgc agg gcc ctg tct 911 Leu Asn Gln Ala Pro Gln Gln Lys Lys Ala Val Arg Arg Ala Leu Ser 290 295 300 gaa tgt tct cac ctc tca gtt ccc cca gct gtc aac ctt g 959 Glu Cys Ser His Leu Ser Val Pro Pro Ala Val Asn Leu Ala Asp Lys 305 310 315 tac cct gaa ctc cct gcc cga gaa gag cct tct tct ggc ctg ctg cct 1007 Tyr Pro Glu Leu Pro Ala Arg Glu Glu Pro Ser Ser Gly L eu Leu Pro 320 325 330 335 ccc cct agt agc cca atg cct agt cct aca cct ggg aaa ctg gga gct 1055 Pro Pro Ser Ser Pro Met Pro Ser Pro Thr Pro Gly Lys Leu Gly Ala 340 345 350 cct gct atg aag cgc tcc atg act gtg ggt gag gaa cag aca gct agc 1103 Pro Ala Met Lys Arg Ser Met Thr Val Gly Glu Glu Gln Thr Ala Ser 355 360 365 tac aaa ttg agc cct ggg aaa ctg ccc atc ttg tct act aaa gag ata 1151 Tyr Lys Leu Ser Pro Gly Lys Leu Pro Ile Leu Ser Thr Lys Glu Ile 370 375 380 cct cct ttc atc tgt gag gaa cca gtg gcc aag aag aga gaa gaa ttg 1199 Pro Pro Phe Ile Cys Glu Glu Pro Val Ala Lys Lys Arg Glu Glu Leu 385 390 395 gct cac ttc agc aac agc agc agc aac tct ggg aag aag gaa ctc ggc 1247 Ala His Phe Ser Asn Ser Ser Ser Asn Ser Gly Lys Lys Glu Leu Gly 400 405 410 415 act gct gga tta tat ctc cat agt aag ctg att cct gaa gga 1295 Thr Ala Gly Leu Tyr Leu His Ser Lys Leu Glu Gln Ile Pro Glu Gly 420 425 430 agc agc aag gaa aaa ggg cag gaa gat ttt agt gaa act aga att gat 1343 Ser Ser Lys Glu Lys Gly Gln Gl u Asp Phe Ser Glu Thr Arg Ile Asp 435 440 445 tca tgc tcg cag gtt tgc cag cga gga gag aaa cag cca gga cag acg 1391 Ser Cys Ser Gln Val Cys Gln Arg Gly Glu Lys Gln Pro Gly Gln Thr 450 455 460 gct ctg gca ggg aag aaa gaa att gag gtc act gca acc cag agc act 1439 Ala Leu Ala Gly Lys Lys Glu Ile Glu Val Thr Ala Thr Gln Ser Thr 465 470 475 cca tcg ttc ctg ttt gaa aag ccc cca cgt gat gga ata gcc agg 1487 Pro Ser Phe Leu Phe Glu Lys Pro Pro Arg Asp Gly Ile Ala Arg Pro 480 485 490 495 gaa gaa gga agg cct gtg gtg agt ggg aca gga aat gac atc acc acc 1535 Glu Glu Gly Arg Pro Val Val Ser Gly Thr Gly Asn Asp Ile Thr Thr 500 505 510 cca ccg aac aag gag ctc cca cca agc cca gag aag aaa aca aag cct 1583 Pro Pro Asn Lys Glu Leu Pro Pro Ser Pro Glu Lys Lys Thr Lys Pro 515 520 525 ttg gcc acc act caa cct gca aag act tca aca tcg aaa gcc aaa aca 1631 Leu Ala Thr Thr Gln Pro Ala Lys Thr Ser Thr Ser Lys Ala Lys Thr 530 535 540 cag ccc act tct ctc cct aag cag cca gct ccc acc acc att ggt ggg 1679 Gln Pro Th r Ser Leu Pro Lys Gln Pro Ala Pro Thr Thr Ile Gly Gly 545 550 555 ttg aat aaa aaa ccc atg agc ctt gct tca ggc tta gtg cca gct gcc 1727 Leu Asn Lys Lys Pro Met Ser Leu Ala Ser Gly Leu Val Pro Ala Ala 560 565 570 575 cca ccc aaa cgc cct gcc gtc gcc tct gcc agg cct tcc atc tta cct 1775 Pro Pro Lys Arg Pro Ala Val Ala Ser Ala Arg Pro Ser Ile Leu Pro 580 585 590 tca aaa gac gtg aag cca aag ccc att gca gat gca aag gct cct gag 1823 Ser Lys Asp Val Lys Pro Lys Pro Ile Ala Asp Ala Lys Ala Pro Glu 595 600 605 aag cgg gcc tca cca tcc aag cca gct tct gcc cca gcc tcc aga tct 1871 Lys Arg Ala Ser Pro Ser Lys Pro Ala Ser Ala Pro Ala Ser Arg Ser 610 615 620 ggg tcc aag agc act cag act gtt gca aaa acc aca aca gct gct gct 1919 Gly Ser Lys Ser Thr Gln Thr Val Ala Lys Thr Thr Thr Thr Ala Ala Ala 625 630 635 gtt gcc tca act ggc cca agc agt agg agc ccc tcc acg ctc ctg ccc 1967 Val Ala Ser Thr Gly Pro Ser Ser Arg Ser Pro Ser Thr Leu Leu Pro 640 645 650 655 aag aag ccc act gcc att aag act gag gga aaa cct gca gaa gtc aag 2015 Lys Lys Pro Thr Ala Ile Lys Thr Glu Gly Lys Pro Ala Glu Val Lys 660 665 670 aag atg act gca aag tct gta cca gct gac ttg agt cgc cca aag agc 2063 Lys Met Thr Ala Lys Ser Val Pro Ala Asp Leu Ser Arg Pro Lys Ser 675 680 685 acc tcc acc agt tcc atg aag aaa acc acc act ctc agt ggg aca gcc 2111 Thr Ser Thr Ser Ser Met Lys Lys Thr Thr Thr Leu Ser Gly Thr Ala 690 695 700 ccc gct gca ggg gtg gtt ccc agc cga gtc aag gcc aca ccc atg ccc 2159 Pro Ala Ala Gly Val Val Pro Ser Arg Val Lys Ala Thr Pro Met Pro 705 710 715 tcc cgg ccc tcc aca act cct ttc ata gac aag aag ccc acc tcg gcc 2207 Ser Arg Pro Ser Thr Thr Pro Phe Ile Asp Lys Lys Pro Thr Ser Ala 720 725 730 735 aaa ccc agc tcc acc acc ccc cgg ctc agc cgc ctg gcc acc aat act 2255 Lys Pro Ser Ser Thr Thr Pro Arg Leu Ser Arg Leu Ala Thr Asn Thr 740 745 750 tct gct cct gat ctg aag aat gtc cgc tcc aag gtt ggc tcc acg gaa 2303 Ser Ala Pro Asp Leu Lys Asn Val Arg Ser Lys Val Gly Ser Thr Glu 755 760 765 aac atc aag cat cag cct gga gga ggc cgg gcc aaa gta gag aaa aaa 2351 Asn Ile Lys His Gln Pro Gly Gly Gly Arg Ala Lys Val Glu Lys Lys 770 775 780 aca gag gca gct gct aca acc cga aag cct gaa tct aat gca gtc act 2399 Thr Glu Ala Ala Ala Thr Thr Arg Lys Pro Glu Ser Asn Ala Val Thr 785 790 795 aaa aca gcc ggc cca att gca agt gca cag aaa caa cct gcg ggg aaa 2447 Lys Thr Ala Gly Pro Ile Ala Ser Ala Gln Lys Gln Pro Ala Gly Lys 800 805 810 810 815 815 gtc cag ata gtc tcc aaa aaa gtg agc tac agc cat att cag tcc aag 2495 Val Gln Ile Val Ser Lys Lys Val Ser Tyr Ser His Ile Gln Ser Lys 820 825 830 tgt ggt tcc aag gac aat att aag cat gtc cct gga ggt ggt aat gtt 2543 Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Asn Val 835 840 845 cag att cag aac aag aaa gtg gac atc tct aag gtc tcc tcc aag tgt 2591 Gln Ile Gln Asn Lys Lys Val Asp Ile Ser Lys Val Ser Ser Lys Cys 850 855 860 ggg tct aag gct aac atc aag cac aag cct ggt gga gga gat gtc aag 2639 Gly Ser Lys Ala Asn Ile Lys His Lys Pro Gly Gly Gly Asp Val Lys 865 870 875 att gaa agt cag aag ttg aac ttc aag gag aag gcc cag gcc aag gtg 2687 Ile Glu Ser Gln Lys Leu Asn Phe Lys Glu Lys Ala Gln Ala Lys Val 880 885 890 895 gga tcc ctc gat aat gtg ggc cac cta cct gca gg ggt 2 Gly Ser Leu Asp Asn Val Gly His Leu Pro Ala Gly Gly Ala Val Lys 900 905 910 att gag acc tac agg ctg acg ttc cgg gca aat gcc agg gcc cgc acc 2783 Ile Glu Thr Tyr Arg Leu Thr Phe Arg Ala Asn Ala Arg Ala Arg Thr 915 920 925 gac cac ggg gcc gac att gtc tcc cgc ccc cca cac ttc cct ggc ggc 2831 Asp His Gly Ala Asp Ile Val Ser Arg Pro Pro His Phe Pro Gly Gly 930 935 940 ccc aac tcg ggc tcc cgg gtc cgg ccc ctt tcc cgg gct gtc cac 2879 Pro Asn Ser Gly Ser Arg Val Leu Gly Pro Leu Ser Arg Ala Val His 945 950 955 tagaccagtg agcgcttggg cgccgtgctg ggcagcccgc taggctcgcc ttccctcctg 2939 ctttgcgtgc ccggggcagc agcagccctg ccccacacct cctctcactc cccagcctgg 2999 gcccatctcc ctgctttggt cttgccccat cactgcgcca ctgctccgtg gaggaggttg 3059 ggagggggtt ggggtggttg aggctaagtt gggatctagg agaggagaac cagattctat 3119 cc tcatcttt ttttggttct ttggtccaaa cccaaaagaa actgacatgc cctcccttct 3179 ccctggatct acctggaggg aagagtggag gtggattccg agtggtgaca ggacgctgac 3239 cgtggagctt aagccactgc ctctccctct ggtcccacaa atgggcgccc ccccctcccc 3299 atgcaggtgg tgtcgggccc ttcttgctgc cctgccccaa gttgggggtc agtgctgcct 3359 gtccccatgc ttaacatacc cgcctagctg ctgtcacatt tttcttgttt tgtcctttta 3419 tttttttcta ataacctaaa aactggcaaa atagttctgc aggttgaagc catgtctaca 3479 tgaaagtcct cagtaagtgt tagagggaac agggcggaga tatccttatg ccacccccgc 3539 tggaggatgt gggcagctta gggccctgga ggcggtgcgg cagggaagag gggtgcagag 3599 gctgtggctg gtgagccggt caggcacaca aggggccctt ggagcgtgga ctggttggtt 3659 ttgccatttt gttgtgtgta tgctgctttt cttttctaac caagaggctg gttttggcat 3719 ctctgtccca ttccctggga tctggtggtc agccctagga taaaaagcca gggctggaga 3779 acaagaaagg gccaggagat ggaattcctt caggccggca cccacaccct aggacatgta 3839 agccctcatg tccaagggag cctcatgcag atagtaggaa atcaggtctg gaaatttaaa 3899 aataaaaggc atgagactaa ggctatctgc ttcccttatg ccctgactgg agaggggagg 3959 gaggagag gc aaggcccaca gagggcatcc cagctaggcc ttgggatggc tgcagtgagg 4019 agaaatcccg ggaactgtat tgacacaaag attcttattg cacttgtatt ttttgtatta 4079 aagtttgcat ggtttctaat aaaggattca aacataagtt tgtagtgaaa tggcctggga 4139 gattccaagg gcttctctgg agggggattg gctgcagtgt agatttgcct ctgaggaggc 4199 tgccccagac ttggcctcct catgccccct cctgacctct gcccttctct ggtcctggca 4259 tccctggaga aggtaggggt cttgacctaa gtttagattt gatctccatg tgcagggagg 4319 ctgtcctggg cctgacaggt cctccccctt tctgaggtag cagtgccttg tggaggtttg 4379 acaccatgtc cctagctccc caagcacaca ccaggaaact gcaggggctc acggaggaag 4439 tgctgcctgg gccaggggga ccagctttcc tccgtagaga ccatgtgcag aacacttctg 4499 ctgtgccaag aacatgaggg agccagtgtt ttgtcagcag gaagaaaggg cctgctggga 4559 tgaaagtggg aaggaaacag ggttgggtag tcaggagaca cctcaggggc aacagcacag 4619 gcccagagta cctgctgcct ccactgcgtc tgtcctgggg tcatgaggat gctgaggttg 4679 acgacaggtt ccaggtcctt tcactccttt ggccaaaggt tgggggtagg tggcccaagt 4739 ggcgtgctct ctaggtagac aacaggagtg gtcagagttc cctcaaagaa ggatcctcca 4799 ctccagagca cc tgagaagg ccgggaccag aggccctgtg tgatgtgtac tccgcagctg 4859 tttggggtgg gacatttctg tacttctcga tttgcttatg gctcagccat tacctgtgtc 4919 agtccatgat tctgttgtaa cagttttaag agtaaatagagcccc <210> 100 <211> 4184 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (67) .. (2700) <400> 100 tcccgcgggc tctcgtcgct gttcacggtt gtcccctgcc tgtcgtgcca cacggcggcg 60 ccgggc atg agc gct tcc acg tcc ggc tcc ggg ccg gag ccc aag ccc 108 Met Ser Ala Ser Thr SerGly c Prog Prog Prog gaa ccg gag cgg gga ccg ctg tca gaa cag 156 Gln Pro Gln Pro Val Pro Glu Pro Glu Arg Gly Pro Leu Ser Glu Gln 15 20 25 30 gtg tcg gag gca gtt tcg gag gca gtg cca aga tcg gaa cct gtg tcc 204 Val Glu Ala Val Ser Glu Ala Val Pro Arg Ser Glu Pro Val Ser 35 40 45 gag acg acg tct gag ccg gag cca ggg gct ggg cag cca tcg gaa ctg 252 Glu Thr Thr Ser Glu Pro Glu Pro Gly Ala Gly Gln Pro Ser Glu Leu 50 55 60 ctg cag ggg tcg cgg ccg ggg tca gag tca agc tca ggt gta ggg gct 300 Leu Gln Gly Ser Arg Pro Gly Ser Glu Ser Ser Ser Gly Val Gly Ala 65 70 75 ggg ccc ttc act aag gcc gca tcg gag ccg ctc tcc cgg gcg gtg ggg 348 Gly Pro Phe Thr Lys Ala Ala Ser Glu Pro Leu Ser Arg Ala Val Gly 80 85 90 agc gcg acc ttt ctc aga ccc gag tca gga tcg ctg cca gcg tta aag 396 Ser Ala Thr Ph e Leu Arg Pro Glu Ser Gly Ser Leu Pro Ala Leu Lys 95 100 105 110 ccc ctg cct ctt ctg cga cca gga cag gcg aag act cct ctt ggg gtt 444 Pro Leu Pro Leu Leu Arg Pro Gly Gln Ala Lys Thr Pro Leu Gly Val 115 120 125 cca atg tcg ggg act ggc acg acc tcc agt gcc cca ctg gcc tta ctg 492 Pro Met Ser Gly Thr Gly Thr Thr Ser Ser Ala Pro Leu Ala Leu Leu 130 135 140 cct ctg gac agc ttc gag ggc tgg ctt ctc aag tgg acc aac tat ctg 540 Pro Leu Asp Ser Phe Glu Gly Trp Leu Leu Lys Trp Thr Asn Tyr Leu 145 150 155 aag ggc tac cag cgc cgc tgg ttc gtg ctg ggc aat ggt ttg ctc tct 588 Lys Gly Tyr Grp Arg Val Leu Gly Asn Gly Leu Leu Ser 160 165 170 tac tac aga aat cag ggt gaa atg gcc cac acg tgc cgt gga acc atc 636 Tyr Tyr Arg Asn Gln Gly Glu Met Ala His Thr Cys Arg Gly Thr Ile 175 180 185 190 aac ctg tcc acc gcg cac att gac acg gag gac tct tgt ggt atc ttg 684 Asn Leu Ser Thr Ala His Ile Asp Thr Glu Asp Ser Cys Gly Ile Leu 195 200 205 ctg acc agt ggg gcc agg agc tac cac ctc aag gcc agc tca gag gt 732 Leu Thr Ser Gly Ala Arg Ser Tyr His Leu Lys Ala Ser Ser Glu Val 210 215 220 gac cgg cag cag tgg atc acc gcc ctg gag ctg gcc aag gcc aag gct 780 Asp Arg Gln Gln Trp Ile Thr Ala Leu Glu Leu Ala Lys Ala Lys Ala 225 230 235 gtc cgc gtg atg aac act cat tca gat gac tct ggg gac gac gac gag 828 Val Arg Val Met Asn Thr His Ser Asp Asp Ser Gly Asp Asp Asp Glu 240 245 250 gct acc acc cca gcc gac aag agc gag ctg cac cac acc ctg aag aat 876 Ala Thr Thr Pro Ala Asp Lys Ser Glu Leu His His Thr Leu Lys Asn 255 260 265 270 ctt tcc ctg aag tta gat gac ctc agc acg tgc aat gac ctc atc gcc 924 Leu Ser Leu Lys Leu Asp Asp Leu Ser Thr Cys Asn Asp Leu Ile Ala 275 280 285 aag cac ggc gcc gca ctc cag cgc tcc ctg aca gag ctg gac ggc ctc 972 Lys His Gly Ala Ala Leu Gln Arg Ser Leu Thr Glu Leu Asp Gly Leu 290 aag atc cca tct gag agt ggg gag aag ctg aag gtg gtg aat gag cgg 1020 Lys Ile Pro Ser Glu Ser Gly Glu Lys Leu Lys Val Val Asn Glu Arg 305 310 315 gcc acc ctc ttc cgc atc aca tcc aat gct atg atc aac g cc tgc agg 1068 Ala Thr Leu Phe Arg Ile Thr Ser Asn Ala Met Ile Asn Ala Cys Arg 320 325 330 gac ttc ttg gaa cta gca gag ata cac agt cgg aaa tgg cag cgg gca 1116 Asp Phe Leu Glu Leu Ala Glu His Ser Arg Lys Trp Gln Arg Ala 335 340 345 350 ctg cag tat gag cag gag cag cgc gtg cac ttg gag gaa acc att gag 1164 Leu Gln Tyr Glu Gln Glu Gln Arg Val His Leu Glu Glu Thr Ile Glu 355 360 365 cag ag ctg gc cag cac aac agc ctc gag cgg gcc ttc cac agt gcc 1212 Gln Leu Ala Lys Gln His Asn Ser Leu Glu Arg Ala Phe His Ser Ala 370 375 380 cct ggc cgg ccg gcc aac ccc tcc aag agc ttc att gag gga ag Gly Arg Pro Ala Asn Pro Ser Lys Ser Phe Ile Glu Gly Ser Leu 385 390 395 ttg act ccc aaa gga gag gac agt gag gaa gat gaa gat acc gag tac 1308 Leu Thr Pro Lys Gly Glu Asp Ser Glu Glu Asp Glu Asp Thr Glu Tyr 400 405 410 ttt gat gcc atg gaa gac tcc aca tcc ttc atc acc gtg atc acc gag 1356 Phe Asp Ala Met Glu Asp Ser Thr Ser Phe Ile Thr Val Ile Thr Glu 415 420 425 430 gcc aag gaa gac agc aga aaa g ct gaa ggt agc acc ggg aca agt tcc 1404 Ala Lys Glu Asp Ser Arg Lys Ala Glu Gly Ser Thr Gly Thr Ser Ser 435 440 445 gtg gac tgg agc tca gca gac aat gta cta gat ggt gcc tcg ctc gtg 1452 Val Asp Trp Ser Ala Asp Asn Val Leu Asp Gly Ala Ser Leu Val 450 455 460 ccc aag ggt tca tcc aaa gtc aag agg cga gtc cgc att ccc aac aag 1500 Pro Lys Gly Ser Ser Lys Val Lys Arg Arg Val Arg Ile Pro Asn Lys 465 470 475 ccc aac tac agc ctt aac ctc tgg agc atc atg aag aac tgc atc ggc 1548 Pro Asn Tyr Ser Leu Asn Leu Trp Ser Ile Met Lys Asn Cys Ile Gly 480 485 490 cgg gag ctc tcc agg atc ccc atg ccg gtg gtg gag ccc ctg 1596 Arg Glu Leu Ser Arg Ile Pro Met Pro Val Asn Phe Asn Glu Pro Leu 495 500 505 510 tcc atg ctc cag cgg ctg aca gag gac ctg gag tac cac cac ctg ctg 1644 Ser Met Leu Gln Arg Leu Thr Glu Leu Glu Tyr His His Leu Leu 515 520 525 gac aag gca gtg cac tgc acc agc tca gtg gag cag atg tgc ctg gtg 1692 Asp Lys Ala Val His Cys Thr Ser Ser Val Glu Gln Met Cys Leu Val 530 535 540 gcc gcc t tc tct gtg tcc tcc tac tcc acc aca gtg cac cgc atc gcc 1740 Ala Ala Phe Ser Val Ser Ser Tyr Ser Thr Thr Val His Arg Ile Ala 545 550 555 aag ccc ttc aac ccc atg ctg ggg gag acc ttc gag ctg gac cgc ct 1788 Lys Pro Phe Asn Pro Met Leu Gly Glu Thr Phe Glu Leu Asp Arg Leu 560 565 570 gac gac atg ggc ctg cgc tcc ctc tgt gag cag gtg agc cac cac ccc 1836 Asp Asp Met Gly Leu Arg Ser Leu Cys Glu His His Pro 575 580 585 585 590 ccc tca gct gcg cac tac gtg ttc tcc aag cat ggc tgg agc ctc tgg 1884 Pro Ser Ala Ala His Tyr Val Phe Ser Lys His Gly Trp Ser Leu Trp 595 600 605 cag gag atc acc atc tcc agc aag ttc cgg gga aaa tac atc tcc atc 1932 Gln Glu Ile Thr Ile Ser Ser Lys Phe Arg Gly Lys Tyr Ile Ser Ile 610 615 620 atg ccg cta ggt gcc atc cac tta gaa ttc cag gcc agt ggg aat cac 1980 Met Prou Ala Ile His Leu Glu Phe Gln Ala Ser Gly Asn His 625 630 635 tac gtg tgg agg aag agc acc tca act gtt cac aac atc atc gtg ggc 2028 Tyr Val Trp Arg Lys Ser Thr Ser Thr Val His Asn Ile Ile Val Gly 64 0 645 650 aag ctc tgg atc gac cag tca ggg gac atc gag att gtg aac cat aag 2076 Lys Leu Trp Ile Asp Gln Ser Gly Asp Ile Glu Ile Val Asn His Lys 655 660 665 670 acc aat gac cgg tgc cag ctg ag ttc ccc tac agc tac ttc tcc 2124 Thr Asn Asp Arg Cys Gln Leu Lys Phe Leu Pro Tyr Ser Tyr Phe Ser 675 680 685 aaa gag gca gcc cgg aag gtg aca gga gtg gtg agt gac agc cag ggc 2172 Lys Glu Ala Ala Arla Thr Gly Val Val Ser Asp Ser Gln Gly 690 695 700 aag gcc cat tac gtg ctg tcc ggc tcg tgg gat gaa caa atg gag tgc 2220 Lys Ala His Tyr Val Leu Ser Gly Ser Trp Asp Glu Gln Met Glu Cys 705 710 710 715 tcc aag gtc atg cat agc agt ccc agc agc ccc agc tct gac ggg aag 2268 Ser Lys Val Met His Ser Ser Pro Ser Ser Pro Ser Ser Asp Gly Lys 720 725 730 cag aag aca gtg tac cag acc ctg tca gcc aag ctg ctg tgg aag aag 2316 Gln Lys Thr Val Tyr Gln Thr Leu Ser Ala Lys Leu Leu Trp Lys Lys 735 740 745 750 tac ccg ctg ccg gag aac gcg gag aac atg tac tac ttc tca gag ctg 2364 Tyr Pro Leu Pro Glu Asn Ala Glu Asn Met Tyr Phe Ser Glu Leu 755 760 765 gcc ctg acc ctc aac gag cac gag gag ggc gta gcg cca acc gac agc 2412 Ala Leu Thr Leu Asn Glu His Glu Glu Gly Val Ala Pro Thr Asp Ser 770 775 775 780 cgc ctg cgg ccc gca cgg ctg atg gag aag ggc cgt tgg gac gag 2460 Arg Leu Arg Pro Asp Gln Arg Leu Met Glu Lys Gly Arg Trp Asp Glu 785 790 795 gcc aat acc gag aag cag cgg ctg gag gag aag cag cgc ctg Tcg cgg Thr508 Glu Lys Gln Arg Leu Glu Glu Lys Gln Arg Leu Ser Arg 800 805 810 cgc cgg cgg ctg gag gcc tgc ggg ccg ggc agc agc tgc agc tcg gag 2556 Arg Arg Arg Leu Glu Ala Cys Gly Pro Gly Serlu Ser Ser Ser Sers 820 825 830 gaa gag aag gag gcg gat gcc tac acg cca ctg tgg ttt gag aag agg 2604 Glu Glu Lys Glu Ala Asp Ala Tyr Thr Pro Leu Trp Phe Glu Lys Arg 835 840 845 ctg gat ccg ctg acc ggg ggt atg tac aag ggc ggc tac 2652 Leu Asp Pro Leu Thr Gly Glu Met Ala Cys Val Tyr Lys Gly Gly Tyr 850 855 860 tgg gag gcc aag gag aag caa gac tgg cat atg tgc ccc aac atc ttc 2700 Trp Glu Ala Lys Glu Lys Gln Asp Trp His Met Cys Pro Asn Ile Phe 865 870 875 tgagcgccac ccttgcaaca aatacaggcg cctgcacagc ctggcccacc tgttcattaa 2760 tgcactcaat ttagtactga atggtctttc tcccagccca ttcccagccc ttcctatttc 2820 ctttcctatt ttttttttct ccccacactt tcttgggact cccaccttgg aaggaggaag 2880 ggctgacctg ggttctctcc agcccccagg tgcgccgggt cacccgtgcc ccttcattat 2940 ggacctgggc cctaccggaa cccctgcccc agttaccaca actcaggccg gctggcccgg 3000 gccatgggct gcgcaaatca ccagccccca acccagggag gaactggccc ctcctaggga 3060 gcctcttcga cttttttaga aaaatgatct ccatttcttt ccagccatga tgtttagtaa 3120 atatttttag taccgcactt agcagacagc tttccaagtg tgctttcttg ccacaaaagt 3180 gtcctggcaa gagcccctta tttttaagac atcaggaagc cagaccgctt tgagttggga 3240 gaattttgta gctcaacata tcaagtcctc gatggtatct gagctgccca cacccccacc 3300 tgccaaggcc ccacagagcc caaaacagaa gggggctgcc ccagcccagc agagcacaga 3360 gtttctggag ctcccatcca cagatgcagg agggggtact gatggtaacc cccatgtgga 3420 tttgagggca gcagtccctg gcctcaccct agccagcctg ggtggctccc tagccccaag 3480 aggccaggaa gggctggaag gc agggcctg caggtgctcc ccgccctgag acccaggccc 3540 caaatcagca ataatgaaca aacccttggc ccagcctggg ctggtgacct gggcaccaga 3600 gaccttgcat ccctcctcat cctaggaggc ccctaggggt gccccatctc agtgtcccct 3660 gaactcttta tttgcctaat ttatatatat atatatgaga tatataaata tatataaaat 3720 agctattttg cttaaatttc tacagtatgt aaaagtgaaa aaatgatgaa gacgggtgca 3780 cctgtctgag tttggccctc atgtgagctg tgcccttccc tctcctcatg cccccttcca 3840 gcggcttctg ccaaccatgg ggggctggac caccatggcc actgacccag cccctcagaa 3900 tcccacactc caatcctttc catttcagtt tagtcctaaa agttcatcac agggtctttc 3960 tttctactcc aggactggtt ttgtttttat atatataaaa aaaaaaagtg aaaacaccaa 4020 tgtgtgaaat gccttacaat gcccactgga gaggcggggc ggggtggggc aggatggccc 4080 cactggggct cctacagagc tgtggaatgt acctctcccc aacactgttt tgttagcgag 4140 caccttttga ccagtaataa aaaaccttgg ctttggagtt ttcc 4184 <210> 101 <211> 3819 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (937) .. (3390) <400> 101 tgtgactata ttgtcctcac tagtagttca gtaattggcc caggagatgc atctaagtta 60 gacaaggcag tgctgtctat tttgtaggca ctttgcattt gttagctgta agaatacagt 120 gatactagca gttggtttgc agcattagag atgtaggtga aggtggagat taaaatgcat 180 gttaaattgt taatgctgac tggaaggaaa agattgtttt gcattttaat atttttaatt 240 tatataaagc tttttaaaag ttacacaata aagaattacc ccctttattc catttggtta 300 cgtgtgtact catgtatata ttttttaagt ttgcctctgg taactttgct ctgttagaaa 360 caaatcaaat atttattaga ttatgttata aatgttgaac tgggccacaa aagtgggttt 420 cttttattaa gcttgatagg atgaagatgt gagaatgaat tgtaagcttg aagtaaaaat 480 tgcttaaatt ttttttccaa gaagaaaggc tgtgttgttt ggtaatagtc agggactgac 540 tgagcatttt ggctgtattc cgaattctgc cactgactca ctgtgttttt tggcaagtaa 600 cttatcctca ctgaaacaag ttcttgattc tttacttctc tgtgtgtaaa gttagcataa 660 taatattgtg ctaacctcag atgggttgtg taatggtttc ccactttaga actttccagc 720 ataaaaatag tatggatttt cagtgccttg ctttttaaaa taattatttc taaattgttg 780 tttattaggt aagtatgttg gacaatttaa atgcaaaaca aaactcttac tatacttttc 840 aaaatatagc aaacctcata aagttttagt tatatataac attttaagga ccatacccta 900 taaagtatga ataactattt tattcattta ttttag tgt cag aaa aaa gag gaa 954 Cys Gln Lys Lys Glu Glu 1 5 ttt att gaa aga att caa ggt tta gat Gat Gat Gat Gat Gat Agall Asp Phe Asp Thr Lys Ala Ala Val 10 15 20 gcc gca cat att caa gag gta act cat aat cag gaa aat gtg ttt gac 1050 Ala Ala His Ile Gln Glu Val Thr His Asn Gln Glu Asn Val Phe Asp 25 30 35 ctg caa tgg atg gaa gtg act gat atg tcg cag gag gac ata gaa cca 1098 Leu Gln Trp Met Glu Val Thr Asp Met Ser Gln Glu Asp Ile Glu Pro 40 45 50 ctc ttg aaa aat atg gca ttg cat cta aaa aga ctt ata gat gag aga 1146 Leu Leu Lys Asn Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg 55 60 65 70 gat gaa cat tca gag act atc ata gaa ctc tct gaa gag cgg gat ggt 1194 Asp Glu His Ser Glu Thr Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly 75 80 85 ctc cat ttt cta ccc cat gcc tct tca tct gca cag tca ccc tgt ggt 1242 Leu His Phe Leu Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gl y 90 95 100 tct cca ggc atg aag cga aca gaa agt cga caa cat ctg tcg gtg gaa 1290 Ser Pro Gly Met Lys Arg Thr Glu Ser Arg Gln His Leu Ser Val Glu 105 110 115 ctg gca gat gct aaa gcc aag ata aga agg ctt agg cag gaa ttg gag 1338 Leu Ala Asp Ala Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu 120 125 130 gaa aag act gag cag ttg ttg gat tgt aaa caa gaa ctt gag caa atg 1386 Glu Les Thr Glu Gln Asp Cys Lys Gln Glu Leu Glu Gln Met 135 140 145 150 gaa ata gaa ctc aaa agg ctg caa caa gag aac atg aat ttg ctt tcg 1434 Glu Ile Glu Leu Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu gat 155 160 gct cgc tct gcc aga atg tac cga gat gaa tta gat gca ctt cga 1482 Asp Ala Arg Ser Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg 170 175 180 gag aaa gca gtc aga gtc gat aag ctt agaa gt gaga gta tat 1530 Glu Lys Ala Val Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr 185 190 195 aaa gag aga cta cat gat att gaa ttt tat aag gca aga gtt gag gaa 1578 Lys Glu Arg Leu His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu 200 205 210 tta aaa gaa gac aat caa gtt tta tta gaa aca aaa acc atg ttg gaa 1626 Leu Lys Glu Asp Asn Gln Val Leu Leu Glu Thr Lys Thr Met Leu Glu 215 220 225 230 gac caa cta gag gga act cgt gct cgt tct gat aaa tta cat gaa tta 1674 Asp Gln Leu Glu Gly Thr Arg Ala Arg Ser Asp Lys Leu His Glu Leu 235 240 245 gaa aaa gag aac tta caa ctg aaa gct aaa ctt cat gat atg gaa atg 1722 Glu Lys Glu Asn Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met 250 255 260 gaa cga gat atg gat aga aaa aag att gaa gaa tta atg gaa gaa aat 1770 Glu Arg Asp Met Asp Arg Lys Lys Ile Glu Glu Lelu Met Glu 265 270 275 atg act ttg gaa atg gca cag aaa caa agt atg gat gaa tca tta cat 1818 Met Thr Leu Glu Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His 280 285 290 ctt ggc tgg gaa ctg gaa cag atacc agt gaa ctt tcc gaa 1866 Leu Gly Trp Glu Leu Glu Gln Ile Ser Arg Thr Ser Glu Leu Ser Glu 295 300 305 310 gca ccc cag aaa tcc ctg ggc cat gag gtg aat gag ttg aca tca agt 1914 Ala Pro Gln Lys Ser L eu Gly His Glu Val Asn Glu Leu Thr Ser Ser 315 320 325 aga tta ttg aag cta gag atg gaa aat caa agt ttg aca aaa acc gta 1962 Arg Leu Leu Lys Leu Glu Met Glu Asn Gln Ser Leu Thr Lys Thr Val 330 335 340 gaa gag ctt cgg act act gtg gat tct gta gaa ggc aat gct tcc aaa 2010 Glu Glu Leu Arg Thr Thr Val Asp Ser Val Glu Gly Asn Ala Ser Lys 345 350 355 atc ctg aaa atg gaa aaa gaa aat caa agg ctc agt aag ag gtt gag 2058 Ile Leu Lys Met Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu 360 365 370 att ctt gaa aat gag att gtt caa gaa aag caa agt ctt cag aat tgt 2106 Ile Leu Glu Asn Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys 375 380 385 390 cag aat tta agc aag gat cta atg aag gag aaa gct cag ctt gaa aaa 2154 Gln Asn Leu Ser Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys 395 400 405 aca atag gaaca aga gaa aat tca gag aga cag att aag ata ctg 2202 Thr Ile Glu Thr Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu 410 415 420 gaa cag gaa aat gaa cat ctg aat caa aca gtg tct tcc tta agg cag 2250 lu Gln Glu Asn Glu His Leu Asn Gln Thr Val Ser Ser Leu Arg Gln 425 430 435 cgg tcc cag ata agt gca gaa gca aga gtg aaa gac att gaa aaa gaa 2298 Arg Ser Gln Ile Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu 440 445 450 aac aaa att ctt cat gaa tct atc aaa gaa aca agt agc aag cta agc 2346 Asn Lys Ile Leu His Glu Ser Ile Lys Glu Thr Ser Ser Lys Leu Ser 455 460 465 470 aag att gaa ttt gaa aaa caa att aaa aaa gaa ttg gaa cat tat 2394 Lys Ile Glu Phe Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr 475 480 485 aaa aaa gaa aaa gga gaa cga gct gaa gaa ctt gaa aat gaa ttg cat lus Lys Arg Ala Glu Glu Leu Glu Asn Glu Leu His His 490 495 500 ctt gaa aaa gaa aat gaa tta tta cag aaa aaa ata act aat tta aaa 2490 Leu Glu Lys Glu Asn Glu Leu Leu Gln Lys Lys Ile Thr Asn Leu Lys 505 510 510 att act tgt gaa aaa att gag gcc tta gaa caa gaa aat tca gag cta 2538 Ile Thr Cys Glu Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu 520 525 530 gaa aga gaa aat aga aaa tta aaa aaa acac g ttt aaa aat 2586 Glu Arg Glu Asn Arg Lys Leu Lys Lys Thr Leu Asp Ser Phe Lys Asn 535 540 545 550 ctg acc ttt cag tta gaa tcc cta gaa aaa gag aat tcc caa ctt gat 2634 Leu Thr Phe Gln Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp 555 560 565 gag gaa aac tta gaa ctg cga agg aat gta gaa tct ttg aag tgt gca 2682 Glu Glu Asn Leu Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala 570 575 580 ag at gct cag cta cag cta gaa aac aaa gaa ctg gaa agt 2730 Ser Met Lys Met Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser 585 590 595 gaa aaa gag caa ctt aag aag ggt ttg gag ctc ctg gtgca Lys Glu Gln Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe 600 605 610 aag aaa aca gaa cgc tta gaa gtt agc tac cag ggt tta gat ata gaa 2826 Lys Lys Thr Glu Arg Leu Glu Val Ser Tyr Gln Gly Leu As Glu 615 620 625 630 aat caa aga ctg caa aaa act tta gag aac agc aat aaa aaa atc cag 2874 Asn Gln Arg Leu Gln Lys Thr Leu Glu Asn Ser Asn Lys Lys Ile Gln 635 640 645 caa tta gag agt gaa cta caa gac tta gag atg gaa aat caa aca ttg 2922 Gln Leu Glu Ser Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Thr Leu 650 655 660 cag aaa aac cta gaa gaa cta aaa ata tct agc aaa aga cta gaa Asgn 2970 Gln Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln 665 670 675 ctg gaa aaa gaa aat aaa tca tta gag caa gag act tct caa ctg gaa 3018 Leu Glu Lys Glu Asn Lys Ser Leu Glu Gln Glu Thr Ser Gln Leu Glu 680 690 aag gat aag aaa caa ttg gag aag gaa aat aag aga ctc cga caa caa 3066 Lys Asp Lys Lys Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln 695 700 705 710 gca gaa att aaa gat acc aca tta gaat gtg aag att gga 3114 Ala Glu Ile Lys Asp Thr Thr Leu Glu Glu Asn Asn Val Lys Ile Gly 715 720 725 aat ttg gaa aaa gaa aac aaa acc cta tcc aaa gaa att ggt ata tat 3162 Asn Leu Glu Lys Glu Asn Lys Thr Ser Lys Glu Ile Gly Ile Tyr 730 735 740 aaa gaa tct tgt gtc cgt ctg aaa gaa cta gaa aaa gaa aat aag gag 3210 Lys Glu Ser Cys Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu 745 750g 755 ctt aaa aga gca act att gat ata aaa acg ttg gtt aca cta cgt 3258 Leu Val Lys Arg Ala Thr Ile Asp Ile Lys Thr Leu Val Thr Leu Arg 760 765 770 gag gat ttg gtg agt gaa aag ttg aag acc caa cag atg aac aat gat 3306 Glu Asp Leu Val Ser Glu Lys Leu Lys Thr Gln Gln Met Asn Asn Asp 775 780 785 790 ctc gaa aaa tta act cat gag ctt gag aag ata ggg tta aat aag gag 3354 Leu Glu Lys Leu Thr His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu 795 800 805 cga ctc tta cat gat gaa caa agt act gat gac agg tgagtactaa 3400 Arg Leu Leu His Asp Glu Gln Ser Thr Asp Asp Arg 810 815 gtctactcgg caaacagttgcaaacagttg aaaatttttt tttttc tt ct catagut tgtagccggg tgcggtggct cacacctata atcccagcac tttgggaggc 3580 tgaagcgggc ggatcacctg aggtcgggag ttcgagatca gcctgaccaa catggggaaa 3640 ccctgtcttt actaaaaata caaaaaaaat tagctgggca tggtggtgca tgcctgtaat 3700 tccagctact caggacgctg aggcaggaga attgcttgaa cttgggaggc tgaggttgcg 3760 gtgagctgag atcgtgccgt tgcactccag cctgggcaac aagagcgaaa ctccatctc 3819 <210> 102 <211> 4139 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (843) <400> 102 att gga ggc tat tac tgg cat cct tta tca gag gtt cac ata tgg gat 48 Ile Gly Gly Tyr Tyr Trp His Pro Leu Ser Glu Val His Ile Trp Asp 1 5 10 15 cct ttg aca aat gtt tgg att cag gga gca gaa ata cca gat tat acc 96 Pro Leu Thr Asn Val Trp Ile Gln Gly Ala Glu Ile Pro Asp Tyr Thr 20 25 30 agg gag agc tat ggt gtt aca tgt tta gga ccc aac att tat gta act 144 Arg Glu Ser Tyr Gly Val Thr Cys Leu Gly Pro Asn Ile Tyr Val Thr 35 40 45 ggg ggc tac agg acg gat aac ata gaa gct ctt gac aca gtg tgg atc 192 Gly Gly Tyr Arg Thr Asp Asn Ile Glu Ala Leu Asp Thr Val Trp Ile 50 55 60 tat aac agt gaa agt gat gaa tgg aca gaa ggt ttg cca atg ctc aat 240 Tyr Asn Ser Glu Ser Asp Glu Trp Thr Glu Gly Leu Pro Met Leu Asn 65 70 75 80 gcc agg tat tac cac tgt gca gtc acc ttg ggt gtc tgt tat gct 288 Ala Arg Tyr Tyr His Cys Ala Val Thr Leu Gly Gly Cys Val Tyr Ala 85 90 95 tta ggt ggt tac aga aaa ggg gct cca gca gaa gag gct gag ttc tat 336 Leu Gly Gly Tyr Arg Lys Gly Ala Pro Ala Glu Glu Ala Glu Phe Tyr 100 105 1 10 gat cct tta aaa gag aag tgg att cct att gca aac atg att aaa ggt 384 Asp Pro Leu Lys Glu Lys Trp Ile Pro Ile Ala Asn Met Ile Lys Gly 115 120 125 gtg gga aat gct act gcc tgt gtc tta cat gat gtt atc tac gtc att 432 Val Gly Asn Ala Thr Ala Cys Val Leu His Asp Val Ile Tyr Val Ile 130 135 140 ggt ggc cac tgt ggc tac aga gga agc tgc acc tat gac aaa gtt cag 480 Gly Gly His Cys Gly Tyr Arg Gly Ser Cys Thr Tyr Asp Lys Val Gln 145 150 155 160 agc tac aat tcc gat atc aac gaa tgg agc ctc atc acc tcc agt cca 528 Ser Tyr Asn Ser Asp Ile Asn Glu Trp Ser Leu Ile Thr Ser Ser Pro 165 170 175 cat cca gaa tat gga ttg tgc tca gtt ccg ttt gaa aat aag ctc tat 576 His Pro Glu Tyr Gly Leu Cys Ser Val Pro Phe Glu Asn Lys Leu Tyr 180 185 190 cta gtc ggt gga caa act aca atc aca gaa tgc tat gac cct gaa caa Val Gly Gly Gln Thr Thr Ile Thr Glu Cys Tyr Asp Pro Glu Gln 195 200 205 aat gaa tgg aga gag ata gct ccc atg atg gaa agg agg atg gag tgc 672 Asn Glu Trp Arg Glu Ile Ala Pro Met Met Glu Arg Arg Met Glu C ys 210 215 220 ggt gcc gtc atc atg aat gga tgt att tat gtc act gga gga tac tcc 720 Gly Ala Val Ile Met Asn Gly Cys Ile Tyr Val Thr Gly Gly Tyr Ser 225 230 235 240 tac tca aag gga acg tat ctt cag agc att gag aaa tat gat cca gat 768 Tyr Ser Lys Gly Thr Tyr Leu Gln Ser Ile Glu Lys Tyr Asp Pro Asp 245 250 255 ctt aat aag tgg gaa ata gtg ggt aat ctt ccc agt gcc atg cgg tct 816 Leu Asn Lys Trp Glu Ile Val Gly Asn Leu Pro Ser Ala Met Arg Ser 260 265 270 cat ggg tgt gtt tgt gtg tat aat gtc taattgaatc tgcagaaatg 863 His Gly Cys Val Cys Val Tyr Asn Val 275 280 accaagatt 98 cctactgtac tcccaaacat ggtgattcat ggtcaagaaa aatcttatat atatatatat 1043 atgtatacac atatatatgt gttcatatgt atgcgttcat acatacgcgc gtatgtatac 1103 atatatgtgt atacatacgt gtgtatgtat acatatatgt gtatacatat gtgtcatat gtgtcatat gtgtgtattat gtgtcatat gtt gaatcagtgg gattaatacc tataatctct ggttttcaaa 1283 ggtaatatgg aatatttgac acttggtaaa aggtgaacta cctttgtagt gaatcttttc 1343 ctcttggtag catcaacact ggggataaat cagaaccatt ctgtggaatg aaatgtttct 1403 caagagccta taatatagta gatagtgcat attaagatgt ctggctgggc atggtggctc 1463 atgcctgtaa tcccagcact ttgggaggct gaggcgggag gatcacttga gcctagaagt 1523 tggagactaa cctggcgaga ccctgtctca aaaaaaaaaa aaaaatcaat ttagctagca 1583 ggaatttgac atttaaagag ggaatcttct ctacctctac aaaatcaaca cttaacactt 1643 ttttcacctt cagaattatt tagaatgtgg atttactttg tctagttttt tcctttatag 1703 tgtaatttat tgttactctc tatttactga ctaccagaga tatacaaaat actgtgcaaa 1763 agattgttac tgttcaaaga gcttacaaac taaatttaaa agaatagcaa gtctgaaaaa 1823 tagaagatag tcaaatattt gtttatgcca agaactgttt ttaattttca gctttgatgt 1883 aaattgctag cttaggtgtc tttagttcaa gcatgttagg aaatcctctt tattcttaaa 1943 tatagataca tgtctgcata tatgattgaa ttttagagcc agaaagcatg tagagcagtt 2003 gtgattagta gaaaatacac tgacaagaag atatttgcat ttatttccca aagctgccag 2063 taactagatt ttgtgactta a gtcatttaa cctctccttg attagagctt cctgagccat 2123 gcacactggc actgcaaatc acagacaggc ctagatacag atcccctcac cccttgctac 2183 atccaaaggt ggcctgggtg gctggagcct ctgggccaga accacctttg tccattttcc 2243 tcagtgtgcc tacagcatcg ctttccatgt gtgccataac ttgggaatag ttgggatgtg 2303 ttgcttaact cctttgcacc attagttatc tgtgagacca tctattccac actcttcatt 2363 ttttaaaaag agacaataat tatttttaac tcactgaagt ttaaaactac ctagcatttc 2423 tgattaaaaa aaatttagaa ggaaaatttt aatgcattta tttcagatgg cgttttaaat 2483 agatacaacc ctttggaaac acaatatggt actacatagc aagggctgta aaaatgacca 2543 tatcctttgc cccataaatt ctacttctat acttttaacc ttaaaaataa ttcagaaaaa 2603 agataaatgc atgaagacat ttatgtctgc attctttata ataacaaaaa ttggggaaaa 2663 aaactccatg tcaagaaagt gggataagaa aaatagtgaa gtattatact gccattaaaa 2723 taattatttg gaagactgta gaaacgtgga catgtttgat atggtaagta aaatgagcac 2783 aatacaaaat agtatgcata ctatgattgt gactttgtaa aatctttatg catgtggaag 2843 gtaatctgca aaacaaattc attgtgttag tgtagcggga tatggaatga ctttatttat 2903 ttaaatcttt tctttaatat tactttg tat tttcaataaa aataaatcac tgtacatagt 2963 aagactgctt gaatttgggc tgattgggtt gcaggatagt ctgaattaat gaaaacaagt 3023 gagttataca ctacttcaat ctgtaattga attgtagact attttattgc tctgaagaac 3083 atttagcaat taatgctaga actaatatgc tgctcagtag tgctttagag atccacttta 3143 tggcataggt gagaacaatt gcagtcacct tcccctcctt tgccagttta tgtaggtcct 3203 atgaactcct gagtcaagtc tggccttctc tggaaagtct ttcctgtttc agccacagta 3263 agactcccat tgtcacattt aagaattggt catttatata tgaattgtgt atctcttggc 3323 taagttagag attatggacc gcatcttatt cttggccttc tcaagatcta gtatttcata 3383 tgtacgtcca gcatacaagg acgatgatat ggattatttt tacagaaaag catgctggag 3443 gtgcttgaag gatcttgaaa atagtttgtg atctgaggta tttaattttc agctcctatt 3503 ttctgtttgt tttttgaatt tttattttta tttttatttt tttattttta gtagagagag 3563 ggtttcacca tgttggccag gcaggtcttg aactcttgac ctcaggtgat ccgcccatct 3623 tggcgtccca aagtgctggg attacaggca taagccactg cacctggcct ctttttgaat 3683 ttttaaaatg ctgtactttg tgtcaaaagc tcctgttttc tgttagaaaa catttttgct 3743 atggatttgt gcacagcaaa aaggattaca a aggtgtaca ggtttgtcaa ctttttcaaa 3803 tttgaagtca ctgcggtatg atgaaaaata ttttactaag gccaaacatt ttagtaatcc 3863 cagcctgtaa tcccacgcct gtaatcccag tactttggga ggctggggtg ggagaattgc 3923 ttgaggccag gagttcgaga ccagtctggg aaacatgggg agaccttatc tgtacaaaaa 3983 ataaaaaaaa ttagcccagc atggtgcatg cctgtagttc cagctacttg ggagactgag 4043 tagggaggat cccttgagcc caggagtttc aggttgcaga gagccatgat cacactgtac 4103 tccatcctga gcaacggagt gagaccttgt ctctac 4139 <210> 103 <211> 4022 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (75) .. (1232) <400> 103 ctcatctcaa aatgctgaac tgctctttgg aagtcgccgg tgctgttgta gttggagtct 60 gttcacgggc ctga gct tcg agg cca ggc tcc tgg gtg tcg tta atg ttc 110 Ala Ser Arg Pro Gly Ser Tpg gc Gcc Ser grp gcc Lec Tg g c Ser g gct cca gca gcc ggg aac agc 158 Gly Ala Ala Gly Arg Gln Pro Ile Gly Ala Pro Ala Ala Gly Asn Ser 15 20 25 tgg cat ttc agt aga acc atg gag gag ctg gtt cat gac ctt gtc tca 206 Trp His Phe Ser Arg Thr Met Glu Glu Leu Val His Asp Leu Val Ser 30 35 40 gca ttg gaa gag agc tca gag caa gct cga ggt gga ttt gct gaa aca 254 Ala Leu Glu Glu Ser Ser Glu Gln Ala Arg Gly Gly Phe Ala Glu Thr 45 50 55 60 gga gac cat tct cga agt ata tct tgc cct ctg aaa cgc cag gca agg 302 Gly Asp His Ser Arg Ser Ile Ser Cys Pro Leu Lys Arg Gln Ala Arg 65 70 75 aaa agg aga ggg aga aaa cgg agg tcg tat aat gtg cat cac ccg tgg 350 Lys Arg Arg Gly Arg Lys Arg Arg Ser Tyr Asn Val His His Pro Trp 80 85 90 gag act ggt cac tgc tta agt gaa ggc tct gat tct agt tta gaa gaa 398 Glu Thr Gly His Cys L eu Ser Glu Gly Ser Asp Ser Ser Leu Glu Glu 95 100 105 cca agc aag gac tat aga gag aat cac aat aat aat aaa aaa gat cac 446 Pro Ser Lys Asp Tyr Arg Glu Asn His Asn Asn Asn Lys Lys Asp His 110 115 120 agt gac tct gat gac caa atg tta gta gca aag cgc agg ccg tca tca 494 Ser Asp Ser Asp Asp Gln Met Leu Val Ala Lys Arg Arg Pro Ser Ser 125 130 135 140 aac tta aat aat aat gtt cga ggg aaa aga cct cta tgg cat gag tct 542 Asn Leu Asn Asn Asn Val Arg Gly Lys Arg Pro Leu Trp His Glu Ser 145 150 155 gat ttt gct gtg gac aat gtt ggg aat aga act ctg cgc agg agg aga 590 Asp Phe Ala Val Asp Asn Val Gly Asn Arg Thr Leu Arg Arg Arg Arg 160 165 170 aag gta aaa cgc atg gca gta gat ctc cca cag gac atc tct aac aaa 638 Lys Val Lys Arg Met Ala Val Asp Leu Pro Gln Asp Ile Ser Asn Lys 175 180 185 cgg aca atg acc cag cca cct gag ggt tgt aga gat cag gac atg gac 686 Arg Thr Met Thr Gln Pro Pro Glu Gly Cys Arg Asp Gln Asp Met Asp 190 195 200 agt gat aga gcc tac cag tat caa gaa ttt acc aag aac aaa gtc aaa 734 Ser Asp A rg Ala Tyr Gln Tyr Gln Glu Phe Thr Lys Asn Lys Val Lys 205 210 215 220 aaa aga aag ttg aaa ata atc aga caa gga cca aaa atc caa gat gaa 782 Lys Arg Lys Leu Lys Ile Ile Arg Gln Gly Pro Lys Ile Gln Asp Glu 225 230 235 gga gta gtt tta gaa agt gag gaa acg aac cag acc aat aag gac 830 Gly Val Val Leu Glu Ser Glu Glu Thr Asn Gln Thr Asn Lys Asp Lys 240 245 250 atg gaa tgt gaa gag caa aaa gtc tca gat gag ctc atg agt gaa agt 878 Met Glu Cys Glu Glu Gln Lys Val Ser Asp Glu Leu Met Ser Glu Ser 255 260 265 gat tcc agc agt ctc agc agc act gat gct gga ttg ttt acc aat gat 926 Asp Ser Ser Ser Leu Ser Ser Thr Asp Ala Gly Leu Phe Thr Asn Asp 270 275 280 gag gga aga caa ggt gat gat gaa cag agt gac tgg ttc tac gaa aag 974 Glu Gly Arg Gln Gly Asp Asp Glu Gln Ser Asp Trp Phe Tyr Glu Lys 285 290 295 300 tca ggt gga gca tgt ggt atc act gga gtt gtg ccc tgg tgg gaa 1022 Glu Ser Gly Gly Ala Cys Gly Ile Thr Gly Val Val Pro Trp Trp Glu 305 310 315 aag gaa gat cct act gag cta gac aaa aat gta cca gat cct gtcttt 1070 Lys Glu Asp Pro Thr Glu Leu Asp Lys Asn Val Pro Asp Pro Val Phe 320 325 330 gaa agt atc tta act ggt tct ttt ccc ctt atg tca cac cca agc aga 1118 Glu Ser Ile Leu Thr Gly Ser Phe Pro Leu Met Ser His Pro Ser Arg 335 340 345 aga ggt ttc caa gct aga ctc agt cgc ctt cat gga atg tct tca aag 1166 Arg Gly Phe Gln Ala Arg Leu Ser Arg Leu His Gly Met Ser Ser Lys 350 355 360 aat att aaa aaa tct gga ggg act cca act tca atg gct aca aac tgg 1214 Asn Ile Lys Lys Ser Gly Gly Thr Pro Thr Ser Met Ala Thr Asn Trp 365 370 375 380 acc agt gag att ccc cta taaaccaaat cttctaatgc taataaatta 1262 Thr Ser Glu Ile Pro Leu 385 gttaccattgg gtt tcgagggaac ctggctcctg tcctcttccc 1322 tggaggaata tcattgaagt gagagcctct ttgatgaaaa gatggggctg tttttgctgg 1382 aggactggta ttcttccttt tagtcagaag tgaacctgac tggggaggct ttctagggat 1442 ttaggttggc ccagggtgga tagaaactac tgtaaattat atatttttct cttttatggt 1502 ttttttttta cattgaatcc atttatgtat acttgctttg ccaaaatgct aacaaagcta 1562 gaaaatttta aacttccaga tcgacaag ta ttccttaatg tttatattgt gactgattaa 1622 gaattaattt ttacatatct gactgttgta aataaaaatc atgatgcatt gacatttatg 1682 gttcattttt agagaagtct tatataacca gcattattta aaatatttgc attttactca 1742 gggtatttta acaagggcta agatgagtag taggtaaggt tgataatctt tgctggagtt 1802 tgtattttgt tcagcttcct ttctacttgg gtaatctgct tgtattgcaa actcattgta 1862 ttttatagta tagctttcat tgtactgcaa aaatcatcct cgttttaaat tagccacagt 1922 gataactagt ctgcactagt agaatcattt accttttaaa ttatctgctt tgtctgatac 1982 ctgaaacaca tcaaaattat tattttggtt tagagcttaa tgaaacatgt gaaagctggt 2042 atttttaaca aatgctgtgt gattctgaat catattgtca tgtttaaaag tgagagctgc 2102 ttgtacatct ttagaatggc agaccatatg tgtcactgtg agtgtcagaa atacttgcat 2162 gagctcattt tcaccaactg gggggaaaat gtaatgtttc tattgatggt ataatttaga 2222 cactataata agttcagcca tttgagttct tcaaaatggt tatattaaaa tgatattttt 2282 attaagcttc aataatgaaa aacaatgtga tttaatatgt gtatttttat attattgtat 2342 ggattaattg ttaattcagc atttaatggc taacttaaat atgattggaa aagaaacttc 2402 aagttgccat tgcttttacc taaagttttt aa agtctgaa agatttcagc aaatgcatta 2462 agcaggaatg tgtgacatct tcttttagat tgcttgtcta atttggagag attaaaaatg 2522 gtaaaatgca actttgagtc tctttacctt tgcatattta aaggtacaat agtgtggtgt 2582 tggtaattgt aagtaagctt ttctgtgcta tgtctttgga gtgaaaattc atgttttttt 2642 tctgaattac ataaatgctt ttgttttatt ttgtataatg actgtctttt agatctgaat 2702 aagtcacttt aaaaccttgg cctatgaact ttgccttatc aatcatgaat ctagatgaat 2762 gctatctagt tcttggttca gttttaccta tttttatttt tggttcactg cttgcttgag 2822 catagctggg atttgtagcc cattttctag gcttattgca atctcactgt ggtattttat 2882 agaagctatt acaactgata ggctagcttc atggtattga tgatacatgg cttaaccata 2942 ctaaaagctg ctttccctct ctaaattgta aaaaggtgat gaagtttcac ttgatggaga 3002 catactatat atgtgtgttt atcatggaac tagtgcatta ggccataagc tgtttttctg 3062 gtctatgttt tttgtattta aaactttact gaagacaatg gactccttcg ggttttcttt 3122 ctttcaaccc tgaattgtcc ttgtttgaat ttttaagtac tgtaattttt tttttcaata 3182 aaatctctga cttgggcaag aaaggtaaga gttccaattt gtgctgctat ttctctgatt 3242 tcatttgcta agttttcatt gttgttgttg ttgctta tgc tgtttatatt atgtataact 3302 ataatatcta gttttaaaaa tcataatctc acaaaacagt catctttaca cagtatccat 3362 gacatctggt aataagaagt gaaatttaat tgccttaaac tttcacactg gaaagccaga 3422 ttgtttttaa gagagattaa ttttctgagc aaagtaaaac acatggagct gcaacccatt 3482 aaacagaagg ccaacaaaag gtttcttaag cagatgaatg atgactgcat aaatataatg 3542 atgtagtatc tttgaaggaa atgacagagg aagaatcttt tactgaaata tcaatgtaaa 3602 cattttttgg gggaaagttt tcagttgtat tatagttgat tctgactatt tgccataact 3662 gtattctata cacttgctga aaacattgaa ttagggaata ctgaatcatg gctcctaagg 3722 gaaagacagg gttaggttcc tggaagcctc tggtcacaac attttcacca actgatcaat 3782 agataacctt gttttgttta tgtttgtgtt tagagacatt taatatatat tgttgactta 3842 ctaacatcga actcatggcc aatagcacta taacttacgg ctgaacaaag cttatcaagt 3902 cttttctcta taaggcacat cccagccttc ttgcacttag gagcactaga cggcatttct 3962 cagcactata caaggggcta tttaaaacag aataatcacc cacaaaaagc acaacaattc 4022 <210> 104 <211> 4119 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (163) .. (2727) <400> 104 cagctgcagt gctctaaaga tcaaggattt tgccttctat tttctatgac cagagattcc 60 tgtgcaaaga gagagtgtca atgaagacct caaagtctgg agaaaaatga cctttcatgg 120 aataagaagt atacctcctt ctacat gc ag t gc ag t gc ag t gct ag c ag t gct ag c g Gly Thr His Asp Ser Gly Ser Val Glu Ser Gln Leu Ile Lys Leu Ile 5 10 15 20 ctc acc atg cat caa ctg ttc aga ctg gtt ttg gga caa aaa gat ctt 270 Leu Thr Met His Gln Leu Phe Arg Leu Val Leu Gly Gln Lys Asp Leu 25 30 35 tca cga gct ggg gac ctc ttc tcc tta gat gac tct gag att gaa gac 318 Ser Arg Ala Gly Asp Leu Phe Ser Leu Asp Asp Ser Glu Ile Glu Asp 40 45 50 agc ctt aca gaa gct ttg gag caa att aag ata att agc tca tct tca 366 Ser Leu Thr Glu Ala Leu Glu Gln Ile Lys Ile Ile Ser Ser Ser Ser 55 60 65 gat tac caa acc aat aac aat gac cag gca gta gtt gaa atc tgt atc 414 Asp Tyr Gln Thr Asn Asn Asn Asp Gln Ala Val Val Glu Ile Cys Ile 70 75 80 aca aga atc aca aca gcc atc aga gag acc gag tcc att gaa aa g cat 462 Thr Arg Ile Thr Thr Ala Ile Arg Glu Thr Glu Ser Ile Glu Lys His 85 90 95 100 gca aag gcc ctt gtg ggg ctc tgg gac tcc tgc ttg gaa cat aac ctg 510 Ala Lys Ala Leu Val Gly Leu Trp Asp Ser Cys Leu Glu His Asn Leu 105 110 115 aga ccc ttt ggg aaa gac gaa gac act cct cat gca aaa atc gca tct 558 Arg Pro Phe Gly Lys Asp Glu Asp Thr Pro His Ala Lys Ile Ala Ser 120 125 130 gat atc atg agt tgc att tta cag aat tac aac cga ccc cca gtg atg 606 Asp Ile Met Ser Cys Ile Leu Gln Asn Tyr Asn Arg Pro Pro Val Met 135 140 145 gca tta gcc atc ccc att gca gtg aaa ttc ctc cac aga ggc aac aag 654 Ala Ala Ile Pro Ile Ala Val Lys Phe Leu His Arg Gly Asn Lys 150 155 160 gaa ctg tgc agg aat atg tct aac tac ctg tct ctg gct gca att acc 702 Glu Leu Cys Arg Asn Met Ser Asn Tyr Leu Ser Leu Ala Ala Ile Thr 165 170 175 180 aag gca gat ctc ctg gct gat cac acg gaa gtt ata gta aag agc ata 750 Lys Ala Asp Leu Leu Ala Asp His Thr Glu Val Ile Val Lys Ser Ile 185 190 195 ctc caa ggt aac acc atg ttg ttg gt tta c ct gct gtg tat gaa 798 Leu Gln Gly Asn Thr Met Leu Leu Arg Val Leu Pro Ala Val Tyr Glu 200 205 210 aag cag cct cag cca att aat aga cac ctg aca gaa ctc ctg gcc ttg 846 Lys Gln Pro Gln Pro Ile Asn Ar His Leu Thr Glu Leu Leu Ala Leu 215 220 225 atg tct cag ctg gaa cag cca gaa cag tac cat cta cta cgg ctt ttg 894 Met Ser Gln Leu Glu Gln Pro Glu Gln Tyr His Leu Leu Arg Leu Leu 230 235 240 cat gta gca gca aag aaa aaa caa ctc gag gta gtt cag aag tgt att 942 His Val Ala Ala Lys Lys Lys Gln Leu Glu Val Val Gln Lys Cys Ile 245 250 255 260 cct ttc cta att ggg cat ttg aag gat tca acc cat aat gac atc atc 990 Pro Phe Leu Ile Gly His Leu Lys Asp Ser Thr His Asn Asp Ile Ile 265 270 275 cta aac atc ctc ata gag ata gca gtc tat gag cca gtg gct ttg aac 1038 Leu Asn Ile Leu Ile Glu Ile Ala Val Tyr Glu Pro Val Ala Leu Asn 280 285 290 agt ttt ctt cca atg ctg aaa gag att ggt gag aga ttc ccc tac ctc 1086 Ser Phe Leu Pro Met Leu Lys Glu Ile Gly Glu Arg Phe Pro Tyr Leu 295 300 305 act gga cag atg gca agg att ta t gga gct gtt ggg cat gtg gat gaa 1134 Thr Gly Gln Met Ala Arg Ile Tyr Gly Ala Val Gly His Val Asp Glu 310 315 320 gag aga gcc agg agc tgc ctg aca tac ctg gtg agc caa ctg gcc aac 1182 Glu Arg Ser Cys Leu Thr Tyr Leu Val Ser Gln Leu Ala Asn 325 330 335 340 atg gag cat tcg ttt cac cat att ctc ctg ctg gag att aaa agc atc 1230 Met Glu His Ser Phe His His Ile Leu Leu Leu Glu Ile Lys Ser Ile 345 350 355 acc gac acc ttc tcc tca atc ttg ggc cct cag agc aga gac atc ttc 1278 Thr Asp Thr Phe Ser Ser Ile Leu Gly Pro Gln Ser Arg Asp Ile Phe 360 365 370 cgc atg agc aac agc ttc acc gcc att gct aaact ctt acc cga caa 1326 Arg Met Ser Asn Ser Phe Thr Ala Ile Ala Lys Leu Leu Thr Arg Gln 375 380 385 ctg gaa aat acc aag gct gga agt ggc agg aga aaa atc agc act gaa 1374 Leu Glu Asn Thr Lys Ala Gly Ser Gly Arg Arg Lys Ile Ser Thr Glu 390 395 400 att gaa ttc cct gag aaa ctg gaa gaa acc aag ctc ata gta act gaa 1422 Ile Glu Phe Pro Glu Lys Leu Glu Glu Thr Lys Leu Ile Val Thr Glu 405 410 415 420 aat ga a gac cat gaa aaa ctc caa gtt aaa atc cag gct ttt gaa gac 1470 Asn Glu Asp His Glu Lys Leu Gln Val Lys Ile Gln Ala Phe Glu Asp 425 430 435 aag ata aat gca ggg agc aat acc cct ggc tct atc aga agt 1518 Lys Ile Asn Ala Gly Ser Asn Thr Pro Gly Ser Ile Arg Arg Tyr Ser 440 445 450 ctg ggc caa gtt tct aaa gaa gaa aga aaa aac att aga ttt aac agg 1566 Leu Gly Gln Val Ser Lys Glu Glu Arg Lys Asn Ile Arg Phe Asn Arg 455 460 465 tca aaa agt ttg gct ttc cac act atg ctc aca aag ggt gtg ggt tca 1614 Ser Lys Ser Leu Ala Phe His Thr Met Leu Thr Lys Gly Val Gly Ser 470 475 480 gat gac ggc gaa gat gaa agg gga gac ata cca gcc agc atc tct 1662 Asp Asp Gly Glu Asp Glu Asn Arg Gly Asp Ile Pro Ala Ser Ile Ser 485 490 495 500 ctt tca gaa ata gac cca ctt ggc caa gga aat gac aag ctg ccg ttt 1710 Leu Ile Asp Pro Leu Gly Gln Gly Asn Asp Lys Leu Pro Phe 505 510 515 aag aca gac act gag aga tca cag ctg ggg gag tct tca gtt tca tac 1758 Lys Thr Asp Thr Glu Arg Ser Gln Leu Gly Glu Ser Ser Val Ser Tyr 520 525 530 cca aat att ata cat ata gac tca gag aat ttg tca gaa act gtt aaa 1806 Pro Asn Ile Ile His Ile Asp Ser Glu Asn Leu Ser Glu Thr Val Lys 535 540 545 gaa aac tcc cag gaa gaa act cca gag aca act gca agt cct ata gaa 1854 Glu Asn Ser Gln Glu Glu Thr Pro Glu Thr Thr Ala Ser Pro Ile Glu 550 555 560 tac caa gat aag ctc tac ttg cac tta aaa aaa aac ctc agc aaa gtg 1902 Tyr Gln Asp Lys Leu Tyr Le Leu Lys Lys Asn Leu Ser Lys Val 565 570 575 580 aaa aaa gca tat gcc atg gaa att gga aag aag att cca gtc cct gat cag 1950 Lys Ala Tyr Ala Met Glu Ile Gly Lys Lys Ile Pro Val Pro Asp Gln 585 590 595 tgt acc att gaa gac act gtg aga agt tgt gta gca aag ttg ttc ttc 1998 Cys Thr Ile Glu Asp Thr Val Arg Ser Cys Val Ala Lys Leu Phe Phe 600 605 610 acc tgc tcc ctg aag ggt cat tac tgc cta tac agt ttt agt 2046 Thr Cys Ser Leu Lys Gly His Tyr Cys Leu Tyr Ser Lys Ser Ser Phe 615 620 625 att ctc atc agc caa gaa cct cag cca tgg atc cag atc atg ttt cta 2094 Ile Leu Ile Ser Gln Glu Pro Gln Pro Trp Ile Gln Ile Met Phe Leu 630 635 640 ttt cag cag agc ctg ttt cct gaa ccc ctg tcc att cag agt cat tct 2142 Phe Gln Gln Ser Leu Phe Pro Glu Pro Leu Ser Ile Gln Ser His Ser 645 650 655 655 660 gtg caa ttc ctc gct ctg tgg gag aag acc cag gca ggg ggt gct 2190 Val Gln Phe Leu Arg Ala Leu Trp Glu Lys Thr Gln Ala Gly Gly Ala 665 670 675 cac agc ttt gaa act gcc atg atg gag tcc acg ttt cca cag cag aag 2238 His Phe Glu Thr Ala Met Met Glu Ser Thr Phe Pro Gln Gln Lys 680 685 690 gat ctg gac cag gta cag ctc cat ctg gaa gaa gtg agg ttc ttt gac 2286 Asp Leu Asp Gln Val Gln Leu His Leu Glu Glu Val Arg Phe Phe 695 700 705 gtg ttt ggc ttc agt gaa aca gca gga gca tgg caa tgc ttc atg tgc 2334 Val Phe Gly Phe Ser Glu Thr Ala Gly Ala Trp Gln Cys Phe Met Cys 710 715 720 aac aat cct gag aaa gca act gtt gta gat ggc cag cct ctc 2382 Asn Asn Pro Glu Lys Ala Thr Val Val Asn Gln Asp Gly Gln Pro Leu 725 730 735 740 ata gaa gga aaa ctt aaa gag aag caa gtc aga tgg aag ttc atc aaa 2430 Ile Glu Gly Lys Leu Lys Glu Lys Gln Val Arg Trp Lys Phe Ile Lys 745 750 755 agg tgg aaa aca cgc tat ttt aca ctg gct gga aat caa ctt ctg ttt 2478 Arg Trp Lys Thr Arg Tyr Phe Thr Leu Ala Gly Asn Gln Leu Leu Phe 760 765 caa aaa gga aag tct aaa gat gac cct gac gac tgc cca ata gaa ctc 2526 Gln Lys Gly Lys Ser Lys Asp Asp Pro Asp Asp Cys Pro Ile Glu Leu 775 780 785 agc aaa gta cag agt gtg aag gct gtg gcc agg gac cgc 2574 Ser Lys Val Gln Ser Val Lys Ala Val Ala Lys Lys Arg Arg Asp Arg 790 795 800 tct ctc ccc cgg gct ttc gaa atc ttc aca gac aat aaa acc tat gtc 2622 Ser Leu Pro Arg Ala Phe Glu Ile Phe Thr Asp Asn Lys Thr Tyr Val 805 810 815 820 ttt aag gcc aag gat gag aag aat gca gaa gaa tgg ctc cag tgc atc 2670 Phe Lys Ala Lys Asp Glu Lys Asn Ala Glu Glu Trp Leu Gln Cys Ile 825 830 835 aac gcc g caa gcc aaa gaa agg gaa agt aga gaa gta acc 2718 Asn Val Ala Val Ala Gln Ala Lys Glu Arg Glu Ser Arg Glu Val Thr 840 845 850 aca tat ctg tagggattta taagtcagcc atgacaatta tacaccacag 2767 Thr Tyr L eu 855 gcattgtatt atcattgcca atgtcaagaa aaagagctaa atttaccaag ccatgttgtt 2827 ttttactaaa taccaatgga attgttgtcc tttaagaaga agggcctaaa atggcaggat 2887 tcttagtaaa tgtcatactc taacagcttt agtattgact tcagaatata tctgatgccc 2947 acaaaaataa aataaaataa aaggagctac agagtatgcc ctcagatagt gtggggccag 3007 gaagggaaaa gtcactgata aaagaacttc tgtagatatg tcatttaaaa ctgtgagaaa 3067 acaacatgaa aagatgcctg aactctccat cctgaggaaa gattagcact tctgatgaaa 3127 atcacagtct gtcaaaggta ttaaaagaaa actttaaaaa aaaaaacctt tagaaacgtt 3187 gaactaatgt acactgagaa aaaccatata acttacttat agacatataa ttacatgatc 3247 ctctcttact acaactgagg ctaacacatg gtaaaatggt tcccaaatca agccagttat 3307 gtcattaaat acttgtcttt cagaattact tatttaatta ttccatttaa gttcatataa 3367 tataatctac agtttagata cttggacata tatcctgccc aaggcactaa gtgtaatata 3427 ggaaaaggat agaaagccat tttctctatc ttcaaaataa tgtgccatct ccgttaaaat 3487 taagacttta aagttctata attttttctt tgtattcaac tttttaatac ctccaaatta 3547 caaacatcta tttttttcac tacatagata tataattaca ctatgataga cagaattcta 3607 gagtgattct caataatcca tgccttggta taatcctctc ccccattgag tgtgggtggg 3667 acatgtaacc tgcttctaac caacagaata tggcaaaagt gatgggatca tctctcccat 3727 attatgttat gttatataac aaaagtgaag agaagttgca gatatacata aggtttctaa 3787 tcagctgact ttgagttaat caaagagatc ccctgggtgg gcctgaccta atcagactag 3847 tcctttaaaa gagagtgaac cagtcagaga ctctctctcc tattagcctt aaataagcaa 3907 gctgccatga gctctacggc tgcaaggaaa taagttttgt gaacaaccat gtgatcttgg 3967 aagaagcatc tgaacctcag ataaaagccc agccccagcc aacgccttgc ttgcagcttt 4027 gtgaaactct gagcagagga cccagctaaa tcacgtttgg actcctgacc cacagaaact 4087 ttcagataat aaatgtatgc tgttttaaat ct 4119 <210> 105 <211> 3563 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2202) <400> 105 acc aca gct aaa gaa gta gtt ttt cat gct gtt cat gaa ttt ggt ttg 48 Thr Thr Ala Lys Glu Val Val Phe His Ala Val His Glu Phe Gly Leu 1 5 10 15 acc ggt gca tcc gac aca tat tct ctc tgt gaa gtt tct gtt act cct 96 Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val Ser Val Thr Pro 20 25 30 gag ggt gtc ata aaa cag aga aga ctt cca gat cag ttc tcc aaa tta 144 Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln Phe Ser Lys Leu 35 40 45 gct gat aga att caa ctc aat gga agg tat tac tta aaa aat aac atg 192 Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu Lys Asn Asn Met 50 55 60 gaa aca gaa acc tta tgt tca gat gaa gat gct caa gaa cta gtt aag 240 Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln Glu Leu Val Lys 65 70 75 80 gaa agc cag cta tcc atg ctg cag ctc agt acc att gag gtg gcc acc 288 Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile Glu Val Ala Thr 85 90 95 cag ctg tca atg agg gac ttt gat ttg ttt cgt aat att gaa ccg act 336 Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn Ile Glu Pro Thr 100 105 11 0 gag tac atc gat gac ctt ttt aag tta aat tcc aaa aca gga aat act 384 Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys Thr Gly Asn Thr 115 120 125 cat ttg aag agg ttt gag gac att gta aac caa gag aca ttc tgg gtt 432 His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu Thr Phe Trp Val 130 135 140 gcc tca gaa att tta act gaa gca aat cag ctc aaa cga atg aag att 480 Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys Arg Met Lys Ile 145 150 155 160 att aag cat ttt att aaa att gca ctt cat tgt cga gaa tgt aag aac 528 Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg Glu Cys Lys Asn 165 170 175 ttc aat tcc atg ttt gca ata ata agt ggc ttg aac ctg gca tct gta 576 Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn Leu Ala Ser Val 180 185 190 gca aga ctc aga gga act tgg gaa aag tta cca agc aaa tac gag aaa 624 Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser Lys Tyr Glu Lys 195 200 205 cat ctt caa gat cta caa gac att ttt gat cca tct aga aac atg gca 672 His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser Arg Asn Met A la 210 215 220 aag tat aga aat att ctt agt agt caa agt atg cag cct cca att att 720 Lys Tyr Arg Asn Ile Leu Ser Ser Gln Ser Met Gln Pro Pro Ile Ile 225 230 235 240 cca ctc ttc cct gtt gtc aag aaa gat atg aca ttt cta cat gaa gga 768 Pro Leu Phe Pro Val Val Lys Lys Asp Met Thr Phe Leu His Glu Gly 245 250 255 aat gac tcc aaa gta gat ggt tta gta aac ttt gag aag tta aga atg 816 Asn Asp Ser Lys Val Asp Gly Leu Val Asn Phe Glu Lys Leu Arg Met 260 265 270 att tcc aag gaa atc cgc caa gtt gtt cga atg act tct gct aac atg 864 Ile Ser Lys Glu Ile Arg Gln Val Val Arg Met Thr Ser Ala Asn Met 275 280 285 gac cca gct atg atg ttt cga cag agg aag aag agg tgg cgg agt ctg 912 Asp Pro Ala Met Met Phe Arg Gln Arg Lys Lys Arg Trp Arg Ser Leu 290 295 300 ggg tca ctg agt caa gga agc aca aat tca aat atg ctg cag 960 Gly Ser Leu Ser Gln Gly Ser Thr Asn Ser Asn Met Leu Asp Val Gln 305 310 315 320 gga ggt gct cac aaa aaa agg gca cgc cgc agc tct ctg ctt aat gcc 1008 Gly Gly Ala His Lys Lys Arg Ala Arg Arg Serg Ser Leu Leu Asn Ala 325 330 335 aag aag cta tat gag gat gcc caa atg gca agg aag gtg aag cag tat 1056 Lys Lys Leu Tyr Glu Asp Ala Gln Met Ala Arg Lys Val Lys Gln Tyr 340 345 350 350 ctt tcc agt ctc gat gag aca gat gag gag aag ttc cag atg atg 1104 Leu Ser Ser Leu Asp Val Glu Thr Asp Glu Glu Lys Phe Gln Met Met 355 360 365 tca tta cag tgg gag cct gca tat ggt acc ttg acc aag aat tta agt 1152 Ser Leu Gln Trp Glu Pro Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser 370 375 380 gag aaa aga tca gcc aaa tca tct gaa atg tct cca gtg cct atg agg 1200 Glu Lys Arg Ser Ala Lys Ser Ser Glu Met Ser Pro Val Pro Met Arg 385 390 395 400 tca gct ggc caa aca act aaa gcc cac ttg cat caa ccc cac aga gta 1248 Ser Ala Gly Gln Thr Thr Lys Ala His Leu His Gln Pro His Arg Val 405 410 415 agc cag gtg ctt cag gtg cca gct gtt aat ttg cac ccc atc agg aag 1296 Ser Gln Val Leu Gln Val Pro Ala Val Asn Leu His Pro Ile Arg Lys 420 425 430 aag gga caa aca aaa gac cct gca ctg aat aca agt tta cct cag aaa 1344 Lys Gly Gln Thr Lys Asp Pro Ala Leu Asn Thr Ser Leu Pro Gln Lys 435 440 445 gtt tta gga aca act gaa gaa ata agt ggt aag aag cat aca gaa gac 1392 Val Leu Gly Thr Thr Glu Glu Ile Ser Gly Lys Lys His Thr Glu Asp 450 455 460 act att tct gtg gcg tca tct tta cat tct agt cct cct gca tct cct 1440 Thr Ile Ser Val Ala Ser Ser Leu His Ser Ser Pro Pro Ala Ser Pro 465 470 475 480 caa ggc tcc cct cac aaa ggt tac aca ctt att cca tca gct aaa tct 1488 Gln Gly Ser Pro His Lys Gly Tyr Thr Leu Ile Pro Ser Ala Lys Ser 485 490 495 gac aac ttg tct gac tcc agc cat agt gag att tct tca cgg tcc agc 1536 Asp Asn Leu Ser Asp Ser Ser His Ser Glu Ile Ser Ser Arg Ser Ser 500 505 510 atc gtg agc aat tgt tct gtt gac tcc atg tct gca gct cta cag gat 1584 Ile Val Ser Asn Cys Ser Val Asp Ser Met Ser Ala Ala Leu Gln Asp 515 520 525 gaa cgg tgt tcc tct cag gcc ctg gca gtc cct gaa tcc act ggg gca 1632 Glu Arg Cys Ser Ser Gln Ala Leu Ala Val Pro Glu Ser Thr Gly Ala 530 535 540 ttg gaa aag aca gag cac gct tca ggg ata gga gat cat agt caa cat 1680 Leu Glu Lys Thr Glu His Ala Ser Gly Ile Gly Asp His Ser Gln His 545 550 555 560 ggc cct ggg tgg aca ctc ttg aag cca tct cta atc aag tgt tta gct 1728 Gly Pro Gly Trp Thr Leu Leu Lys Pro Ser Leu Ile Lys Cys Leu Ala 565 570 575 gtc tca tcg tct gtg agc aat gaa gag att tct caa gag cat atc att 1776 Val Ser Ser Ser Val Ser Asn Glu Glu Ile Ser Gln Glu His Ile Ile 580 585 590 590 ata gaa gca gct gac agt ggt cgt agt tgg act tcg tgt tca agc 1824 Ile Glu Ala Ala Asp Ser Gly Arg Gly Ser Trp Thr Ser Cys Ser Ser 595 600 605 agc tcc cat gac aac ttc caa agc ctt cca aac cca aaa agc tgg gat 1872 Ser Ser His Asp Asn Phe Gln Ser Leu Pro Asn Pro Lys Ser Trp Asp 610 615 620 ttt ttg aac tct tac aga cat acc cat ttg gat gac ccc att gct gaa 1920 Phe Leu Asn Ser Tyr Arg His Thr His Leu Asp Asp Pro Ile Ala Glu 625 630 635 640 gtt gaa ccc act gac tct gag ccc tat tcc tgt tct aaa agc tgc tct 1968 Val Glu Pro Thr Asp Ser Glu Pro Tyr Ser Cys Ser Lys Ser Cys Ser 645 650 655 aga act tgt ggg cag tgt aaa gga agc cta gag aga aa g agt tgg acc 2016 Arg Thr Cys Gly Gln Cys Lys Gly Ser Leu Glu Arg Lys Ser Trp Thr 660 665 670 tcc tcc agt tct ctg tct gac acg tat ga gaa cca aac tat ggg aca gtt 2064 Ser Ser Ser Ser Leu Ser Asp Thr Tyr Glu Pro Asn Tyr Gly Thr Val 675 680 685 aaa cgg aga gta ttg gag agc acc cca gct gag tca tct gaa ggc ttg 2112 Lys Arg Arg Val Leu Glu Ser Thr Pro Ala Glu Ser Ser Glu Gly Leu 690 695 700 gac ccc aag gat gcc act gac cca gtt tat aaa act gtc act tca agt 2160 Asp Pro Lys Asp Ala Thr Asp Pro Val Tyr Lys Thr Val Thr Ser Ser 705 710 715 720 aca gaa aag ggc ttg att gaa aat gaa caa gtt tca gca gtc 2202 Thr Glu Lys Gly Leu Ile Glu Asn Glu Gln Val Ser Ala Val 725 730 tagcctttgg atgacctatt tgaaaaccac tgaaagtcgt ggaggaatgg gcaagaacca 2262 cctcatgatt ctgcaggcca ttgctaacga acagctcatt gctacaacca gtccagaggt 2322 tttattccct ctactccgag caatgaaata gacctgagtt atgcttcctt tcatttaatt 2382 tctgcagata aatagtttcc tgagcaatgg atgctatgcc tggataccag tctccacttt 2442 gcacgccgga actgccttgg gaccacagtt acagaaaaaa tgtaaactca g agtgatcct 2502 tgtgtatatt gctatagatt tttctttaac aagctatttt aaagataatg gcattattat 2562 ttccaagcca tagcttgggc tgaaggacaa attgaaattg tctgccaata ccaaggatat 2622 tcttgtatat ttgaaaaata acttattatt tgaattgttg tggttttgtt tgtatttgag 2682 agctcttgtt agctgatatt catgtttgag gtcataaaat tgtctctggt ctgaccaaac 2742 agaagtcatc tttacagagg tgatatgctt gatctacaca gagatgtgac ttgatctgta 2802 gcaccaatgc aatgtaggtc tcagtttgag agaaatagga agccctttgc agttgaggtg 2862 ttaggaacct gctggtcatg gtgtggaagg ccaaatgaag ctgccacagg gtttcttgtc 2922 agtcctttgg gaaatgggag ggagtagttt ggggaggagg gtgggaaccc taatttccac 2982 agaatgaaat tttgatgtta aatgacatgt atacaaattc ttccttaagt gaaagttatg 3042 ctgcatcgaa ttgtaactga aagtatagat ccaacaaata gagactgggt tctagagagt 3102 tctggtctat agaaacccaa aactaaaatc tctcataact caagtatgga atactttttt 3162 taaagaaatt cttatcatgg gtgttgtaat aatgaagacg aatttgactt tatgcagtgt 3222 tctgcagcat gcctccccca catctcatag caccaggttg tgtctgacct gacataccct 3282 gcagctctca gctggctgca gtaacatttt gtgggagaaa gaggagctgg agttaca gaa 3342 atgattgtct cttggttctc agtttttagc ccttgagagg acatactttt ccagcctcat 3402 gggtatggca ctcttaatta aaatttcagt gactgtttac tggatgaggc agatttttca 3462 catttttgca aattaaatat attttattatttatttatttatttatttatttatttattg <210> 106 <211> 4049 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1560) .. (3563) <400> 106 aaagactatt cagtgatgat catttgttaa tgacaaagca aatcactagt aaatttggaa 60 tgattaataa agaaaactta aagattgagt gaaatatatg tttcaactac ttccttcaga 120 aatgttcaag gaattagttt catcatatgg tatctgttac atgatttttt ttggtagggg 180 aatttattga tttgtaagtc atattcagga atctttgtac attaaaaaat tgcagacaac 240 ttgggggtga agtaaaaatg cacataagtg cattaacagt acttattact cagaaaatga 300 tcaataagga attaatgtga cgattcctgg ggaattaaga tacaccaaga gcctagtaga 360 aatttgccca ggattcttgg gtattaacag ccttcctctt aaaaagagac ttgggatctc 420 ctctcatgtt tttttcatct gaaagacctc atgttcagct gcacagtgtt ccgttacatc 480 ctgttgggcc attagttcag tcctgtcatg gagagaagaa agtcacctac aaagacttgg 540 aagctacctc tgcagcattc ctggtattcc ttgaaaatct cctgtttcag aaccaagttg 600 ctccagcctt accttgagaa ctggcatgag tgtagtttga aatttagatg tcttttattt 660 tttccttttt actaataaag ctcataaggt attttcatat tctagttata aaactgaaaa 720 gtctgcaagt agtgatccag gaaggtagga aattattccc tgggagacag gaaagcacac 780 aaggtagtaa ttcagttttt gattctctta cattttttgt ttagatagtg attgtctagc 840 ctaattcctt ggattttttt aatatcatat acttcctaaa agcagtgagg ttacaggtta 900 gattttgacg ttttggaaga gccaccacta gtataattgc tttcctgctt tatgtctttg 960 gatcttttga aattaatttt gactggaatt attttcaaaa caaataggca aaataacact 1020 ttatcattat cattggtcat atacctagtg catttgtcta tgatatgttt ttgagtatat 1080 gacactgaaa tattagtgta tctatgatac taaatcattt ttatatggct aaaatcatct 1140 tcagtaagaa ctctcttagg atatgaattt aagtgaaaat ttactgtctt ttttttaaaa 1200 catgatgaaa cagtaatcta tagagcaatt tcattagtat atgtgagtaa tgatggttta 1260 gttaactcta caggctgggt aagggctcat aagaaagctt ctaaagctct gtgctttgtg 1320 ttcctctgtg aatgtccatt ctacttctct ttctaataat gcatgctttt ctttttgtaa 1380 acaaaatgtt gacttcatgg atcaattaaa gagaattgta aaaacctaaa ttggcttcag 1440 ttaacagtta aaaaaaaccc cttcaattgg aagaaaaaaa atttaattca tagatttcaa 1500 tccacacaaa atcatgtcgt cttctctgtt tacacctaat gactaacctt aatctctaa 1559 acc att aat ggg gtg att cta att tct gtc ttc ttt tcc ttt ttc ttc 1607 Thr Ile Asn Gly Val Ile Leu Ile Ser Val Phe Phe Ser Phe Phe Phe 1 5 10 15 ctg cat ccc atg tt g tct gtg gtg gtt tgt gtg gtt gga ctc tcc cct 1655 Leu His Pro Met Leu Ser Val Val Val Cys Val Val Gly Leu Ser Pro 20 25 30 ggt cag tat ttt tat ttc cag gag gtg ttc cct gtc ttg gct gca aag 1703 Gly Gln Tyr Phe Tyr Phe Gln Glu Val Phe Pro Val Leu Ala Ala Lys 35 40 45 cac tgt atc atg cag gcc aat gct gag tac cat cag tct atc ctg gca 1751 His Cys Ile Met Gln Ala Asn Ala Glu Tyr His Gln Ser Ile Leu Ala 50 55 60 aaa cag cag aag aaa ttt gga gaa gaa att gca agg tta cag cat gca 1799 Lys Gln Gln Lys Lys Phe Gly Glu Glu Ile Ala Arg Leu Gln His Ala 65 70 75 80 gca gaa ctg att aaa aca gtg gca tct cgc tat gat gaa tat gtt aat 1847 Ala Glu Leu Ile Lys Thr Val Ala Ser Arg Tyr Asp Glu Tyr Val Asn 85 90 95 gtg aag gat ttt tct gac aaa atc aat cgt gcc ctt gct gca gca aag 1895 Val Lys Asp Phe Ser Asp Lys Ile Asn Arg Ala Leu Ala Ala Ala Lys 100 105 110 aag gat aat gac ttc att tat cat gat cga gtt cca gac ctt aaa gat 1943 Lys Asp Asn Asp Phe Ile Tyr His Asp Arg Val Pro Asp Leu Lys Asp 115 120 125 cta gat cct att ggc aaa gcc aca ctt gtg aaa tct acc ccg gtc aat 1991 Leu Asp Pro Ile Gly Lys Ala Thr Leu Val Lys Ser Thr Pro Val Asn 130 135 140 gta ccc atc agt cag aaa ttt act gat ctg ttt gag aag atg gtt ccc 2039 Val Pro Ile Ser Gln Lys Phe Thr Asp Leu Phe Glu Lys Met Val Pro 145 150 155 160 gtg tca gta cag cag tct ttg gct gcc tat aat cag agg aaa gcc gat 2087 Val Ser Val Gln Gln Ser Leu Ala Ala Tyr Asn Gln Arg Lys Ala Asp 165 170 175 ttg att aac aga tca att gct cag atg aga gaa gcc acc act ttg gca 2135 Leu Ile Asn Arg Ser Ile Ala Gln Met Arg Glu Ala Thr Thr Leu Ala 180 185 190 aat ggg gtg cta gct tcc ctt aat ctt cca gca gca att gaa gat gtg 2183 Asn Gly Val Leu Ala Ser Leu Asn Leu Pro Ala Ala Ile Glu Asp Val 195 200 205 tct gga gac act gta cct cag tct ata ttg act aaa tcc aga tct gtg 2231 Ser Gly Asp Thr Val Pro Gln Ser Ile Leu Thr Lys Ser Arg Ser Val 210 215 220 att gaa cag gga ggc atc cag act gtt gat cag ttg att aaa gaa ctg 2279 Ile Glu Gln Gly Gly Ile Gln Thr Val Asp Gln Leu Ile Lys Glu Leu 225 230 235 240 cct gaa tta ctg caa cga aat aga gaa atc cta gat gag tca tta agg 2327 Pro Glu Leu Leu Gln Arg Asn Arg Glu Ile Leu Asp Glu Ser Leu Arg 245 250 255 ttg ttg gat gaa gaa gaa gca acc gat atat aga gca aaa ttt 2375 Leu Leu Asp Glu Glu Glu Ala Thr Asp Asn Asp Leu Arg Ala Lys Phe 260 265 270 aag gaa cgt tgg caa agg aca cca tcc aat gaa ctg tat aag cct tta 2423 Lys Glu Arg Trp Gln Arg Thr Ser Asn Glu Leu Tyr Lys Pro Leu 275 280 285 aga gca gag gga acc aac ttc aga aca gtt tta gat aaa gct gtg cag 2471 Arg Ala Glu Gly Thr Asn Phe Arg Thr Val Leu Asp Lys Ala Val Gln 290 295 300 gca gat gga caa gtg aaa gaa tgt tac cag tct cat cgt gac acc atc 2519 Ala Asp Gly Gln Val Lys Glu Cys Tyr Gln Ser His Arg Asp Thr Ile 305 310 315 320 gtg ctt ttg tgt aag cca gag cct gag ctg aat gct gcc atc cct tct 2567 Val Leu Leu Cys Lys Pro Glu Pro Glu Leu Asn Ala Ala Ile Pro Ser 325 330 335 gct aat cca gca aag acc atg cag ggc agt gag gtt gta aat gtc tta 2615 Ala Asn Pro Ala Lys Thr Met Gln Gly Ser Glu Val Val Asn Val Leu 340 345 350 aaa tcc tta ttg tca aat ctt gat gaa gta aag aag gaa aga gag ggt 2663 Lys Ser Leu Leu Ser Asn Leu Asp Glu Val Lys Lys Glu Arg Glu Gly 355 360 365 ctg gag aat gac ttg aaact gtg aat ttt gac atg aca agc aag ttt 2711 Leu Glu Asn Asp Leu Lys Ser Val Asn Phe Asp Met Thr Ser Lys Phe 370 375 380 ttg aca gcc ctg gct caa gat ggt gtg ata aat gaa gaa gct ctt tct 2759 Leu Thr Ala Gln Asp Gly Val Ile Asn Glu Glu Ala Leu Ser 385 390 395 400 gtt act gaa cta gat cga gtc tat gga ggt ctt aca act aaa gtc caa 2807 Val Thr Glu Leu Asp Arg Val Tyr Gly Gly Leu Thr Thr Lys Val Gln 405 410 415 gaa tct cta aag aaa cag gag gga ctt ctt aaa aat att cag gtc tca 2855 Glu Ser Leu Lys Lys Gln Glu Gly Leu Leu Lys Asn Ile Gln Val Ser 420 425 430 cat cag gaa ttt tca aaa atg aaa caa tct aat aat gaa gct aac tta 2903 His Gln Glu Phe Ser Lys Met Lys Gln Ser Asn Asn Glu Ala Asn Leu 435 440 445 aga gaa gaa gtt ttg aag aat tta gct act gca tat gac aac ttt gtt 2951 Arg Glu Glu Val Leu Lys Asn Leu Ala Thr Ala Tyr Asp Asn Phe Val 450 455 460 gaa ctt gta gct aat ttg aag gaa ggc aca aag ttt tac aat gag ttg 2999 Glu Leu Val Ala Asn Leu Lys Glu Gly Thr Lys Phe Tyr Asn Glu Leu 465 470 475 470 gaa atc ctg gtc agg ttc cag aac aaa tgc agt gat ata gtt ttt 3047 Thr Glu Ile Leu Val Arg Phe Gln Asn Lys Cys Ser Asp Ile Val Phe 485 490 495 gca cgg aag aca gaa aga gat gaa ctc tta aag cag agc 3095 Ala Arg Lys Thr Glu Arg Asp Glu Leu Leu Lys Asp Leu Gln Gln Ser 500 505 510 att gcc aga gaa cct agt gct cct tca att cct aca cct gcg tat cag 3143 Ile Ala Arg Glu Pro Ser Ala Pro Ser Ile Pro Thr Pro Ala Tyr Gln 515 520 525 tcc tca cca gca gga gga cat gca cca act cct cca act cca gcg cca 3191 Ser Ser Pro Ala Gly Gly His Ala Pro Thr Pro Pro Thr Pro Ala Pro 530 535 535 540 aga acc atg ccg cct act aag ccc cag ccc cca gcc agg cct cca cca 3239 Arg Thr Met Pro Pro Thr Lys Pro Gln Pro Pro Ala Arg Pro Pro Pro 545 550 555 560 cct gtg ctt cca gca aat cga gct cct tct gct act gct cca tct cca 3287 Pro Val Leu Pro Ala Asn Arg Ala Pro Ser Ala Thr Ala Pro Ser Pro 565 570 575 gtg ggg gct ggg act gct gcg cca gct cca tca caa acg cct ggc tca 3335 Val Gly Ala Gly Thr Ala Ala Pro Ala Pro Ser Gln Thr Pro Gly Ser 580 585 590 gct cct cct cca cag gcg cag gga cca ccc tat ccc acc tat cca gga 3383 Ala Pro Pro Pro Gln Ala Gln Gly Pro Pro Tyr Pro Thr Tyr Pro Gly 595 600 605 tat cct ggg tat tgc caa atg ccc atg ccc atg ggc tat aat cct tat 3431 Tyr Pro Gly Tyr Cys Gln Met Pro Met Pro Met Gly Tyr Asn Pro Tyr 610 615 620 gcg tat ggc cag tat aat atg cca tat cca cca gtg tat cac cag agt 3479 Ala Tyr Gly Gln Tyr Asn Pro Tyr Pro Pro Val Tyr His Gln Ser 625 630 635 640 cct gga cag gct cca tac ccg gga ccc cag cag cct tca tac ccc ttc 3527 Pro Gly Gln Ala Pro Tyr Pro Gly Pro Gln Gln Pro Ser Tyr Pro Phe 645 650 655 cct cag ccc cca cag cag tct tac tat cca cag cag taatatgtct 3573 Pro Gln Pro Pro Gln Gln Ser Tyr Tyr Pro Gln Gln 660 665 gctcagcagc tcagctgatt cagatcagag ggaaagaaat accaaccctg caataagtgt 3633 actaaact ct acgctctggt taatgtaatg tactctcctg gactgaatgc agtgtataat 3693 ttctgtctac agctagaagc tgtgccccag ttccacattt gattacacat gtgagatttg 3753 ctgctgttgc agtataaaca ctaggtataa taggatttga aattgcatta cagttcataa 3813 aaattgaaaa tgagaaatta aacctgcaag tgaaacattt gaaacgatta tactttctac 3873 ataagacatg gttgggacat cagatactta caaagatggt ttaagtatgg atactagaga 3933 aaattaagtt ttctttctct ttggtttatt gatttggttt aatttccatt atgctatttt 3993 gcataatcaa ggcactgtaa atcttataat tttaaaataa attacttaag aacagt 4049 <210> 107 <211> 3934 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1431) .. (3551) <400> 107 gatggagctg gtggctggtc tccacttgtg tctaacaaat accagtggtt gcagattgac 60 cttggagaga gaatggaggt caccgctgtg gccactcaag ggggatatgg tagctccaac 120 tgggtgacca gctacctcct gatgttcagt gatagtggct ggaactggaa acaatatcgc 180 caagaggaca gcatctgggg tttttcagga aatgcaaatg cagacagtgt tgtgtactat 240 agactccagc cttctatcaa agccagattt ctgcgcttca tccctttgga atggaacccc 300 aagggcagaa ttggaatgcg aatcgaagtg ttcggatgtg catacagatc agaagtggtt 360 gatcttgatg gaaaaagttc ccttctctac agatttgatc aaaaatccct gagcccaata 420 aaagacatta tttctttgaa attcaaaacc atgcagagtg atgggattct actccacagg 480 gaagggccaa atggagatca catcacactg caattaagaa gagcaagact ctttttactt 540 attaattcag gtgaagctaa actgccttcc acttccaccc tggtcaatct caccctgggc 600 agcctgctag atgatcagca ttggcattca gtgctcatcc agcgtttggg caaacaagtc 660 aacttcacag tggacgaaca caggcatcat ttccatgcac ggggagaatt caatctcatg 720 aatcttgatt atgagatcag ctttggaggg attccagcac ctggaaaatc agtgtcattc 780 ccacatagaa attttcatgg atgtttagaa aatctctatt ataatggagt ggatatcatt 840 gatttggcca agcagcaaaa accacagatc attgctatgg gaaatgtgtc attttcttgt 900 tcacaaccac aatctatgcc cgtgactttt ctgagctcca ggagttattt agcactgcca 960 gacttctctg gagaggagga ggtttctgcc acttttcaat ttcgaacttg gaataaggca 1020 gggcttctgc tgttcagtga acttcagctg atttcagggg gtatcctcct ctttctgagt 1080 gatggaaaac ttaagtcgaa tctctaccag ccaggaaaat tacccagtga catcacagca 1140 ggtgtcgaat taaatgatgg gcagtggcat tctgtctctt tatctgctaa aaagaatcac 1200 ttgagtgtgg cggtggacgg ccagatggct tctgctgctc ctctgctggg gcctgagcag 1260 atttattcgg gtggcaccta ttattttgga ggttgtcctg acaaaagctt tggatccaaa 1320 tgtaaaagtc cacttggtgg atttcaggga tgtatgaggc tcatttctat cagcggcaaa 1380 gtggtagatc tgatttcagt tcagcagggg tcccttggga acttcagtga cct tca 1436 Pro Ser 1 gat aga ctc atg tgg cat ctc aga cag act agt gat ggt ctc ctc tct 1484 Asp Arg Leu Met Trp His Leu Arg Gln Thr Ser Asp Gly Leu Leu Ser 5 10 15 ttc tcc ccc cat ttc tgc ata caa gaa act gca tgg acc atc ata cag 1532 Phe Ser Pro His Phe Cys Ile Gln Glu Thr Ala Trp Thr Ile Ile Gln 20 25 30 cac aac ggc tct gac tta aca aga gtc aga aat act aat cca gag aac 1580 His Asn Gly Ser Asp Leu Thr Arg Val Arg Asn Thr Asn Pro Glu Asn 35 40 45 50 cca tat gct ggg ttt ttc gag tat gtg gcc agc atg gag caa ctt cag 1628 Pro Tyr Ala Gly Phe Phe Glu Tyr Val Ala Ser Met Glu Gln Leu Gln 55 60 65 gcc act att aac cgt gca gag cac tgt gaa cag gag ttt act tat tac 1676 Ala Thr Ile Asn Arg Ala Glu His Cys Glu Gln Glu Phe Thr Tyr Tyr 70 75 80 tgc aag aag tca cgg ctg gtc aat aag caa gat gga acc cct ctg agt 1724 Cys Lys Lys Ser Arg Leu Val Asn Lys Gln Asp Gly Thr Pro Leu Ser 85 90 95 tgg tgg gta gga aga acc aat gaa acg caa acc tac tgg gga ggt tct 1772 Trp Trp Val Gly Arg Thr Asn Glu Thr Gln Thr Tyr Trp Gly Gly Ser 100 105 110 tcg cct gat ctt caa aaa tgt act tgt gga tta gag gga aac tgc att 1820 Ser Pro Asp Leu Gln Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile 115 120 125 130 gat tct cag tat tac tgc aat tgt gat gct gac cgg aat gaa tgg acc 1868 Asp Ser Gln Tyr Tyr Cys Asn Cys Asp Ala Asp Arg Asn Glu Trp Thr 135 140 145 aa t gac act gga ttg ctt gct tat aaa gaa cat ctt cca gta act aag 1916 Asn Asp Thr Gly Leu Leu Ala Tyr Lys Glu His Leu Pro Val Thr Lys 150 155 160 atc gtg att aca gac aca ggc cga ctg cat tca gaa gca gct tat aaa 1964 Ile Val Ile Thr Asp Thr Gly Arg Leu His Ser Glu Ala Ala Tyr Lys 165 170 175 ctg ggg cct ctg ctc tgc cgg gga gac aga tca ttt tgg aat tca gct 2012 Leu Gly Pro Leu Leu Cys Arg Gly Asp Arg Ser Phe Trp Asn Ser Ala 180 185 190 tcc ttt gat acc gag gct tca tat ctt cat ttt cct acc ttc cac gga 2060 Ser Phe Asp Thr Glu Ala Ser Tyr Leu His Phe Pro Thr Phe His Gly 195 200 205 210 gaa ctt agc gcg gat gta tct ttc ttt ttt aag aca aca gct tca tct 2108 Glu Leu Ser Ala Asp Val Ser Phe Phe Phe Lys Thr Thr Ala Ser Ser 215 220 225 ggg gta ttt tta gag aac ttg ggg att gct gat ttt ata cgg ata gag 2156 Gly Val Phe Leu Glu Asn Leu Gly Ile Ala Asp Phe Ile Arg Ile Glu 230 235 240 ctt cgc tct ccg aca gta gtg act ttt tca ttt gat gtg ggg aat ggg 2204 Leu Arg Ser Pro Thr Val Val Thr Phe Ser Phe Asp Val Gly A sn Gly 245 250 255 cct ttt gaa atc tca gtg cag tca ccc acc cac ttc aac gac aac cag 2252 Pro Phe Glu Ile Ser Val Gln Ser Pro Thr His Phe Asn Asp Asn Gln 260 265 270 tgg cac cat gtg agg gtt gaa agg aac atg aag gag gcc tcc ctt caa 2300 Trp His His Val Arg Val Glu Arg Asn Met Lys Glu Ala Ser Leu Gln 275 280 285 290 gtg gat cag ctg aca cca aag aca cag ccc gcc ccc gct gat ggg cat 2348 Val Asp Gln Leu Thr Pro Lys Thr Gln Pro Ala Pro Ala Asp Gly His 295 300 305 gtc ctg tta cag ctc aac agt cag ctc ttc gtg ggt gga acg gcc acc 2396 Val Leu Leu Gln Leu Asn Ser Gln Leu Phe Val Gly Gly Thr Ala Thr 310 315 320 aga cag aga ggc ttt ctg ggc tgc att cgg tct ctg cag ttg aat ggg 2444 Arg Gln Arg Gly Phe Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly 325 330 335 atg acc ctg gat ttg gaa gag gag gca g gag ga g gag gaa gaga gcc gtg cag 2492 Met Thr Leu Asp Leu Glu Glu Arg Ala Gln Val Thr Pro Glu Val Gln 340 345 350 cca ggt tgt agg gga cat tgc agc agc tat ggg aag tta tgc cgc aat 2540 Pro Gly Cys Arg Gly His Cys Ser Ser Ty r Gly Lys Leu Cys Arg Asn 355 360 365 370 gga ggg aaa tgc aga gaa aga ccc att ggg ttc ttt tgt gac tgc act 2588 Gly Gly Lys Cys Arg Glu Arg Pro Ile Gly Phe Phe Cys Asp Cys Thr 375 380 380 385 ttc tct tac aca ggg cca ttc tgc tca aat gag att tct gca tat 2636 Phe Ser Ala Tyr Thr Gly Pro Phe Cys Ser Asn Glu Ile Ser Ala Tyr 390 395 400 ttt gga tct ggc tca tcc gtg ata tac aat ttt caa gaa aat tat ctt Phe Gly Ser Gly Ser Ser Val Ile Tyr Asn Phe Gln Glu Asn Tyr Leu 405 410 415 tta agt aaa aac tcc agc tcc cac gct gct tca ttt cat ggt gat atg 2732 Leu Ser Lys Asn Ser Ser Ser His Ala Ala Ser Phe His Gly Asp Met 420 425 430 aag ctg agc aga gaa atg atc aaa ttt agt ttc cga aca aca cga aca 2780 Lys Leu Ser Arg Glu Met Ile Lys Phe Ser Phe Arg Thr Thr Arg Thr 435 440 445 450 cca agc ttg ctg cttt gtt ttg tcc ttt tac aaa gaa tac ctt tct 2828 Pro Ser Leu Leu Leu Phe Val Ser Ser Phe Tyr Lys Glu Tyr Leu Ser 455 460 465 gtg atc att gcc aaa aat gga agt ttg cag atc agg tac aag tta aat 2876 Val Ile Ile Al a Lys Asn Gly Ser Leu Gln Ile Arg Tyr Lys Leu Asn 470 475 480 aaa tat caa gag cct gat gtt gtt aac ttt gat ttt aaa aac atg gct 2924 Lys Tyr Gln Glu Pro Asp Val Val Asn Phe Asp Phe Lys Asn Met Ala 485 490 495 gat gga caa ctt cac cac ata atg att aac aga gaa gaa gga gtg gtc 2972 Asp Gly Gln Leu His His Ile Met Ile Asn Arg Glu Glu Gly Val Val 500 505 510 ttt ata gag att gac gat aat aga agg aga ca g cac ctg tca tca 3020 Phe Ile Glu Ile Asp Asp Asn Arg Arg Arg Gln Val His Leu Ser Ser 515 520 525 530 ggc aca gaa ttc agt gca gtc aaa tct ctg gta ttg ggc agg att tta 3068 Gly Thr Glu Lyser Ala Ser Leu Val Leu Gly Arg Ile Leu 535 540 545 gaa cac agt gat gtg gac cag gag act gca ctg gca ggt gcg cag ggc 3116 Glu His Ser Asp Val Asp Gln Glu Thr Ala Leu Ala Gly Ala Gln Gly 550 555 560c ttcca tgc ctc tct gca gtg cag ctc agc cac gtg gcc cct ctg 3164 Phe Thr Gly Cys Leu Ser Ala Val Gln Leu Ser His Val Ala Pro Leu 565 570 575 aag gca gct ctg cac ccc agc cac cca gac cct gtc act gtt agca 3212 Lys Ala Ala Leu His Pro Ser His Pro Asp Pro Val Thr Val Thr Gly 580 585 590 cac gtg acc gag tcc agc tgt atg gcc cag cct ggc act gat gcc aca 3260 His Val Thr Glu Ser Ser Cys Met Ala Gln Pro Gly Thr Asp Ala Thr 595 600 605 610 tca agg gaa agg aca cac tcg ttt gca gat cat tct gga aca ata gat 3308 Ser Arg Glu Arg Thr His Ser Phe Ala Asp His Ser Gly Thr Ile Asp 615 620 625 625 gac aga gag ccc ctt gct aat gca atc aaa agt gac tct gca gta att 3356 Asp Arg Glu Pro Leu Ala Asn Ala Ile Lys Ser Asp Ser Ala Val Ile 630 635 640 gga ggt ctg ata gct gtt gtg att ttt atc ttg ctt tgc atc act gcc 3404 Gly Gly Leu Ala Val Val Ile Phe Ile Leu Leu Cys Ile Thr Ala 645 650 655 ata gct gtt cgc att tat cag cag aaa agg tta tat aaa aga agt gag 3452 Ile Ala Val Arg Ile Tyr Gln Gln Lys Arg Leu Tyr Lys Arg Ser Glu 660 665 670 gca aaa agg tca gag aat gta gac agt gct gag gct gtt ctg aaa agt 3500 Ala Lys Arg Ser Glu Asn Val Asp Ser Ala Glu Ala Val Leu Lys Ser 675 680 685 690 gag ctt aat ata caa aat gca gtc aat gaa aat cag aaa gag tac ttc 3548 Glu Leu Asn Ile Gln Asn Ala Val Asn Glu Asn Gln Lys Glu Tyr Phe 695 700 705 ttc tgattggcag ctatgattta acataaaatt atgatagttt gttttaatag 3601 Phe ccaggggttc tcaatggaaa aacgaatgct cttacactga atgtacaggc agtgggcttg 3661 cagcactgcc atcttgccat gtacaggctt ggggtggctc caggaagcct cgtccagtga 3721 tatatttctc atagcattca ttctatggaa caagaaatta gatattgctg ttaattttca 3781 actgttctgg tatgatctaa aacaagttta acctgcttaa tggctacagt ttttacatgt 3841 gaaaactgta gccttggtct cttaaccatg taatacataa gttttgttag aggtaaaaat 3901 taaatttgc att gat <210> 108 <211> 4599 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1708) .. (3687) <400> 108 acaattcagt gtggacagtg cctggtggaa actattcagc tttccaatca tctccaagtc 60 ccttgtgaat ggttcgtcca gagccaaaag cctgttgaca agctggagaa acacatgccg 120 aagtacttaa gacagaaact acgcgctgaa ttaaagccaa agacacggat cttcgaaatc 180 cagcccattt ctggagtctt ggatcctggt gagaagtcca acgtgcaagt gaaattcatg 240 ccaaaagaag agaaattcta cagccaaacc ctggtgtttc agattgccca gagtgctcaa 300 aagcttaccc tcctggcacg tgggcaaggt ctagagccac gcctggaatt tagtccttca 360 gtcctggatc tggggccact gctactttgt gcacctggag acgaggccga ggtgatagtg 420 aagaatccct gcaacttccc cattgagttt tattccttag aatttgatca gcagtatctc 480 atagaagaaa agatcttgcg gaagctgaag ggctatgatt cctacaacac cctgctgctg 540 cctccccgca accctgggga gaagctgccc ccagaactgt acgagtactt caaagagata 600 aagaagtcaa aagaggagca gatgagggcg aaatatctgg agaatctggc acaggagaat 660 gaagaggaag atataacctc atcagatcag ggaacctcca atagcacaaa gaggacatcg 720 ctgagccgag ggatctctgt cacatccaac ctggaagaat ggcacgccct gttggtcgag 780 tccaaaacct acctagagga agaggaggat gaggaaagcc tggaaaaaat cattttccaa 840 actgacaagc ttcagagcat tgacagccac tccatggagg aagttggaga ggtggaaaac 900 aacccagtga gcaaagcaat cgctcgccac ctgggcattg acatttctgc agaaggccgc 960 ctggccaaga accggaaagg catcgccatt atcattcacg ggacaccctt gtcaggaaag 1020 tcagccaatg ccgttagcgt ggccaagtac tacaacgcag cctgcctgag catcgactcc 1080 attgtgctgg aagctgtggc caacagcaac aacatcccag ggatccgggc ctgtgagctc 1140 tgcatcaggg ctgccataga gcagtccatg aaggaaggag aggaggctgc tgagtgactg 1200 ctaccgagga gtggtgtttg atggcctcga cactctcttt gctcggaatg ctgcagccgc 1260 cctcctctgc ctgctgaagg ccattggcag ccgggagcat atatacattc tcaacatggc 1320 ccaggattac gcagccatga aggcccagga gaaagccaaa aaggagcaag aagaacgcaa 1380 gcacaaggga gctcttgaga aagagaagga gggtctccaa aacatggatg aggaagaata 1440 tgatgccctg actgaggagg agaaactcac attcgatcgg gggattcagc aggcgctccg 1500 cgagcggaag aagagggagc aggagaggct ggcaaaggaa atgcaagaaa agaagctaca 1560 gcaggagctg gagcgacaaa aggaagagga tgagctgaaa cggagggtca aaaaaggaaa 1620 gcagggaccc attaaggagg agccccccat gaagaaatct caagcagcaa acaagcagct 1680 actgtgtgct gaattcc tgc tatgtga cac tcc ctg ctg gga act gtg aat aga 1734 His Ser Leu Leu Gly Thr Val Asn Arg 1 5 tcc cat cac cat cta tct cca gtc tcc aca aca ccc gct gag gga gat 1782 Ser His His His Leu Ser Pro Val Ser Thr Thr Pro Ala Glu Gly Asp 10 15 20 25 atg atc atc acc atc att ttg gag atg agg aag ctg gaa tgc agc aca 1830 Met Ile Ile Thr Ile Ile Leu Glu Met Arg Lys Leu Glu Cys Ser Thr 30 35 40 gtt cct ccg ctc acc aaa gtg gat gtc aag atg gag aca atc gaa agg 1878 Val Pro Pro Leu Thr Lys Val Asp Val Lys Met Glu Thr Ile Glu Arg 45 50 55 aaa ata tct gtt agg gaa caa aca atg tct gag aag gaa gag cta aat 1926 Lys Ile Ser Val Arg Glu Gln Thr Met Ser Glu Lys Glu Glu Leu Asn 60 65 70 aag aag aaa agg aac atg ggc gat gtc agc atg cat ggg ctt cct ctt 1974 Lys Lys Lys Arg Asn Met Gly Asp Val Ser Met His Gly Leu Pro Leu 75 80 85 gtc cag gac caa gag gac agt gaa ggg gac atc tca aag gac ccc gac 2022 Val Gln Asp Gln Glu Asp Ser Glu Gly Asp Ile Ser Lys Asp Pro Asp 90 95 100 105 aag caa ctg gcc cag aag ttt aag acc tat gaa ttg aca ctg aag gat 2070 Lys Gln Leu Ala Gln Lys Phe Lys Thr Tyr Glu Leu Thr Leu Lys Asp 110 115 120 gtc cag aac atc ctc atg tac tgg gac cgg aag caa gga gtc cag ctg 2118 Val Gln Asn Ile Leu Met Tyr Trp Arg Lys Gln Gly Val Gln Leu 125 130 135 cct cct gca ggg atg gag gaa gct ccc cat gag ccc gac gac cag cgc 2166 Pro Pro Ala Gly Met Glu Glu Ala Pro His Glu Pro Asp Asp Gln Arg 140 145 150 cag gtc ccc tcg ggt ggg cgc agg ggc cgc aag gac cgg gag aga gag 2214 Gln Val Pro Ser Gly Gly Arg Arg Gly Arg Lys Asp Arg Glu Arg Glu 155 160 165 cgc ctg gag aag gag cgc ctg gag agg gag aag gcg gg cgg Arg gag Arg Leu Glu Lys Glu Arg Leu Glu Arg Glu Lys Ala Glu Arg Glu Arg 170 175 180 185 ctg gag aag ctg cga gcc ctg gag gag cgg agc gac tgg gag ggg gaa 2310 Leu Glu Lys Leu Arg Ala Leu Glu Glu Arg Ser Gly Glu 190 195 200 ggg gag gag gac cac gaa gag aag aag gag aag gac ctg ggc gta ccc 2358 Gly Glu Glu Asp His Glu Glu Lys Lys Glu Lys Asp Leu Gly Val Pro 205 210 215 ttc ctt aac atc cag aca cca gac ttt gaa ggc ttg agc tgg aag cag 2406 Phe Leu Asn Ile Gln Thr Pro Asp Phe Glu Gly Leu Ser Trp Lys Gln 220 225 230 gcc cta gag agc gac agg ctt ccc aaa gga gag cag gct caa gag gag 2454 Ala Leu Glu Asp Arg Leu Pro Lys Gly Glu Gln Ala Gln Glu Glu 235 240 245 cag acc agc tca tct aag ggg ggc aaa cag aaa atg aaa gaa aag ata 2502 Gln Thr Ser Ser Ser Lys Gly Gly Lys Gln Lys Met Lys Glu Lys Ile 250 255 260 265 gac caa gtc ttc gag agt cag aaa gac aag cgt cac atg gcc tta aac 2550 Asp Gln Val Phe Glu Ser Gln Lys Asp Lys Arg His Met Ala Leu Asn 270 275 280 agg aag gtc ctt tct ggg gaa cct gct gga acct tcc cag ctg tca 2598 Arg Lys Val Leu Ser Gly Glu Pro Ala Gly Thr Ile Ser Gln Leu Ser 285 290 295 gat aca gac ctg gac aac ttc aac ggg cag cac tcc cag gag aaa ttc 2646 Asp Thr Asp Leu Asp Asn Phe Asn Gly Gln His Ser Gln Glu Lys Phe 300 305 310 acc aga ctg aat cac ttc cgg tgg atc gtg cca gcc aat ggc gag gta 2694 Thr Arg Leu Asn His Phe Arg Trp Ile Val Pro Ala Asn Gly Glu Val 315 320 325 acg ttg cag gtg cac ttc tct tct gat gag ttc ggg aac ttt gac caa 2742 Thr Leu Gln Val His Phe Ser Ser Asp Glu Phe Gly Asn Phe Asp Gln 330 335 340 345 acc ttt aac ttt gag atc cta gga act tgc tgc cag tac cagc tac 2790 Thr Phe Asn Phe Glu Ile Leu Gly Thr Cys Cys Gln Tyr Gln Leu Tyr 350 355 360 tgc cga ggc atc tgc act tac cca tac att tgc caa gac cca aaa gtg 2838 Cys Arg Gly Ile Cys Thr Tyr Pro Tyr Ile Cys Asp Pro Lys Val 365 370 375 gta ttt cct cag cgg aag atg gac atg aag aca aat gag gtc atc ttt 2886 Val Phe Pro Gln Arg Lys Met Asp Met Lys Thr Asn Glu Val Ile Phe 380 385 390 aag aag aag tat gtt atg agc acg gag acg tac tac ttt ggg cca cta ctt 2934 Lys Lys Tyr Val Met Ser Thr Glu Thr Tyr Tyr Phe Gly Pro Leu Leu 395 400 405 tgt gga aaa tca aga gat aag tac aag tca tcc tta ttc cca ggc aac 2982 Cys Gly Lys Ser Arg Asp Lys Tyr Lys Ser Ser Leu Phe Pro Gly Asn 410 415 420 425 atg gag acg cta aca atc ctg aac act tcc tta atg gtg gtg gag gca 3030 Met Glu Thr Leu Thr Ile Leu Asn Thr Ser Leu Met Val Val Glu Ala 430 435 440 tcc ttc tat ttt cag aat gat gtc aaa gca aac acg tac ttc ctg gaa 3078 Ser Phe Tyr Phe Gln Asn Asp Val Lys Ala Asn Thr Tyr Phe Leu Glu 445 450 455 ccc aac acc atg gtc act g aaac aag cag ata tta aac gta 3126 Pro Asn Thr Met Val Leu Lys Pro Asn Glu Lys Gln Ile Leu Asn Val 460 465 470 tgg gcc tac cct act tca gtt ggt gtc ttt gaa gac agc att gtc tgc 3174 Trp Ala Tyr Pro Thr Ser Val Gly Val Phe Glu Asp Ser Ile Val Cys 475 480 485 tgc atc aat gac aac cca gag cca gcc atc ttc caa tta agc tgc cag 3222 Cys Ile Asn Asp Asn Pro Glu Pro Ala Ile Phe Gln Leu Ser Cys Gln 490 495 500 505 ggg atc cgc ccg gaa cta gag ctg gaa ccc agg caa tta cat ttt gac 3270 Gly Ile Arg Pro Glu Leu Glu Leu Glu Pro Arg Gln Leu His Phe Asp 510 515 520 cgg ctc ttg ctg cac aga cag gaa tcc cgg gta gcc aat 3318 Arg Leu Leu Leu His Arg Gln Glu Ser Arg Val Val Leu Leu Arg Asn 525 530 535 gtc acg ctc ctg cct gtg gcc tgg cgg atc acc agc ctg gag cac ttg 3366 Val Thr Leu Leu Pro Val Ala Trp Arg Ile Thr Ser Leu Glu His Leu 540 545 550 ggt gat gat ttc act gta tcc ctg atg cag ggg acc atc ccc cct gag 3414 Gly Asp Asp Phe Thr Val Ser Leu Met Gln Gly Thr Ile Pro Pro Glu 555 560 565 gct gag tac ggc ctg cac ctg tac ttt cag ccc acc aag cct gtc aac 3462 Ala Glu Tyr Gly Leu His Leu Tyr Phe Gln Pro Thr Lys Pro Val Asn 570 575 580 585 atc aag aag gct att cgg ttg gag gtt tta gat gca gaa aat ctt ctt 3510 Lys Lys Ala Ile Arg Leu Glu Val Leu Asp Ala Glu Asn Leu Leu 590 595 600 ggt gtt gtt cag att gaa aat atc atg gtc ttt gca gag gca tac gac 3558 Gly Val Val Gln Ile Glu Asn Ile Met Val Phe Ala Glu Ala Tyr Asp 605 610 615 atc gcc ttg gac atc acc ttc ccc aaa gga gct gaa ggg gga ctg gat 3606 Ile Ala Leu Asp Ile Thr Phe Pro Lys Gly Ala Glu Gly Gly Leu Asp 620 625 630 ttt ggg att gtc agg gag gca g aag cag ccc ctg caa ttg 3654 Phe Gly Ile Val Arg Val Thr Glu Glu Ala Lys Gln Pro Leu Gln Leu 635 640 645 aag aac cgt ggg aaa tat gag atc gcg ttc agg taactggaat cccatcagat 3707 Lys Asn Arg Glys Tyr Glu Ile Ala Phe Arg 650 655 660 gtaaggccat caagtccgcc gtgtggagga atgtggggaa atatgagatc gtgttcaggt 3767 aacctgaatc ccatagggtt tgcggccgtc aagtccaccg tggggaatag cgtgtctggg 3827 aaacttatca gtcagtcaag gaaatcataa gaaccgtctc tgcttttttg cctcccttgg 3887 cttcaaaaga atggaattcc acctgctaag gaagcagaga ttctcacact gctctcaact 3947 ctgcagctta acagggccct ttaagtggcc cggatgtacc tggccagttg gaaccatagg 4007 tgtctgggaa tggaggaaga gacttagggg aagaggccgg gagggggaga ttctaggggt 4067 gagaagaggt cccagggtgg agggagagac tggagatggg cgacctggcc tcaagctgtc 4127 ctgccttctg ccagctctta tctgctttac aaggagacct tcttcagcag atttcatgtg 4187 aagaaagggc tttccttttt cattacattc taagaatcac gatattgtac aatccaaata 4247 gtagcttggt agaatagagc tctggcttgt gctcatcccc agagataaaa aatgaaacac 4307 agaggctggg tgtgatggct catgcctgta atcccagcac tgtaggaggt gaaggcaggc 4367 agattgcttg agcccaggag ttggagacca gcctgagcaa agtggcaaga cccccctgcc 4427 tctacaaaat acaaaaaaag ttagctaggc gtggtggtca tatcacttgt agtcccatct 4487 acttgggaga ctggaatggg aggatcgctt gagccc agag aggtcaaggc tgcagtgagc 4547 cgtgatcgtg ccactgcact ccagcctcag caacagagcg agaccctgtc tc 4599 <210> 109 <211> 2197 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2196) <400> 109 ccg gtc cct gca gag cga tcc ccg ggc cca gat atg gac gca gca gag 48 Pro Val Pro Ala Glu Arg Ser Pro Gly Pro Asp Met Asp Ala Ala Glu 1 5 10 15 ccg gga ctc ccc cca ggt cct gag ggc agg aag agg tac agt gac atc 96 Pro Gly Leu Pro Pro Gly Pro Glu Gly Arg Lys Arg Tyr Ser Asp Ile 20 25 30 ttc cgg agc ctg gac aac ctc gaa atc tca ctg ggg aac gtg acc ctt 144 Phe Arg Ser Leu Asp Asn Leu Glu Ile Ser Leu Gly Asn Val Thr Leu 35 40 45 gag atg ctg gct gga gac cct cta ctc tca gaa gac cca gaa cct gac 192 Glu Met Leu Ala Gly Asp Pro Leu Leu Ser Glu Asp Pro Glu Pro Asp 50 55 60 aag acc cct aca gcc act gtt acc aac gaa gcc agc tgt tgg agc ggc 240 Lys Thr Pro Thr Ala Thr Val Thr Asn Glu Ala Ser Cys Trp Ser Gly 65 70 75 80 ccc tcc cca gag ggt cct gta ccc ctc aca ggg gag gaa ctg gac ttg 288 Pro Ser Pro Glu Gly Pro Val Pro Leu Thr Gly Glu Glu Leu Asp Leu 85 90 95 cgg ctc att cgg aca aag ggg ggt gtg gac gca gcc ctg gaa tat gcc 336 Arg Leu Ile Arg Thr Lys Gly Gly Val Asp Ala Ala Leu Glu Tyr Ala 100 105 1 10 aag acc tgg agc cgc tat gcc aag gaa ctg ctt gcc tgg act gaa aag 384 Lys Thr Trp Ser Arg Tyr Ala Lys Glu Leu Leu Ala Trp Thr Glu Lys 115 120 125 aga gcc agc tat gag ctg gag ttt gct aag ag acc atg aag atc gct 432 Arg Ala Ser Tyr Glu Leu Glu Phe Ala Lys Ser Thr Met Lys Ile Ala 130 135 140 gaa gct ggc aag gtg tcc att caa cag cag agc cac atg cct ctg cag 480 Glu Ala Gly Lys Val Ser Ile Gln Gln Gln Ser His Met Pro Leu Gln 145 150 155 160 tac atc tac acc ctg ttt ctg gag cac gat ctc agc ctg gga acc ctg 528 Tyr Ile Tyr Thr Leu Phe Leu Glu His Asp Leu Ser Leu Gly Thr Leu 165 170 175 gcc atg gag aca gtg gcc cag cag aaa aga gac tac tac cag ccc ctc 576 Ala Met Glu Thr Val Ala Gln Gln Lys Arg Asp Tyr Tyr Gln Pro Leu 180 185 190 gcc gcc aaa cgg act gag att gag aag tgg cgg aag gag ttc aag gag 624 Ala Ala Lys Arg Thr Glu Ile Glu Lys Trp Arg Lys Glu Phe Lys Glu 195 200 205 cag tgg atg aag gag cag aag cgg atg aat gag gcg gtg cag gca ctg 672 Gln Trp Met Lys Glu Gln Lys Arg Met Asn Gla Ala Gln L eu 210 215 220 cgg cgc gcc cag ctg cag tat gtg caa cgc agc gag gac ctg cgg gca 720 Arg Arg Ala Gln Leu Gln Tyr Val Gln Arg Ser Glu Asp Leu Arg Ala 225 230 235 240 cgc tcc cag ggg tcc cct gag gcc ccc cag gcc tcg ccg gga 768 Arg Ser Gln Gly Ser Pro Glu Asp Ser Ala Pro Gln Ala Ser Pro Gly 245 250 255 cct agc aag cag cag gag cgg cgg cgg cgc tcg cga gag gag gcc cag 816 Pro Ser Lys Gln Gln Glu Arg Arg Arg Arg Ser Arg Glu Glu Ala Gln 260 265 270 gcc aag gcg cag gag gcc gag gcg ctg tac cag gcc tgt gtc cgc gag 864 Ala Lys Ala Gln Glu Ala Glu Ala Leu Tyr Gln Ala Cys Val Arg Glu 275 280 aac gcg cgg cag cag gac ctg gag atc gcc aag cag cga atc gtg 912 Ala Asn Ala Arg Gln Gln Asp Leu Glu Ile Ala Lys Gln Arg Ile Val 290 295 300 tcg cac gtg cgc aag ctg gtg gtt gtt cgg 960 Ser His Val Arg Lys Leu Val Phe Gln Gly Asp Glu Val Leu Arg Arg 305 310 315 320 gtg acg ctg agt ctc ttc ggg ctg cgg ggg gcg cag gca gag cgt ggc 1008 Val Thr Leu Ser Leu Phe Gly Leu Arg Gly Al a Gln Ala Glu Arg Gly 325 330 335 ccc cgc gcc ttc gcc gcc ctg gcc gag tgc tgt gcg ccc ttt gag ccg 1056 Pro Arg Ala Phe Ala Ala Leu Ala Glu Cys Cys Ala Pro Phe Glu Pro 340 345 350 ggc cag cg gag ttt gta cgg gcg ctg cgg ccc gag gcc ccg 1104 Gly Gln Arg Tyr Gln Glu Phe Val Arg Ala Leu Arg Pro Glu Ala Pro 355 360 365 ccg ccc ccg ccg ccc gcc ttc tcc ttc cag gag ttc ctt ccc tcc Pro Pro Pro Ala Phe Ser Phe Gln Glu Phe Leu Pro Ser Leu 370 375 380 aac agc tcc cct ctg gac atc aga aag aag ctc tct ggg cct ctt cct 1200 Asn Ser Ser Pro Leu Asp Ile Arg Lys Lys Leu Ser Gly Pro Leu Pro 385 390 395 400 cca agg ctg gat gag aat tca gct gag cca ggc cct tgg gag gat ccg 1248 Pro Arg Leu Asp Glu Asn Ser Ala Glu Pro Gly Pro Trp Glu Asp Pro 405 410 415 ggc aca ggc tgg cgc tgg caa ggg actca ggc ccc act ccg ggc agc 1296 Gly Thr Gly Trp Arg Trp Gln Gly Thr Pro Gly Pro Thr Pro Gly Ser 420 425 430 gat gtg gac agc gtg ggt ggc ggc agc gag tct cgg tcc ctg gac tca 1344 Asp Val Asp Ser Val Gly Gly Ser Glu Ser Arg Ser Leu Asp Ser 435 440 445 ccc act tcc agc cca ggc gct ggc acg agg cag ctg gtg aag gct tcg 1392 Pro Thr Ser Ser Pro Gly Ala Gly Thr Arg Gln Leu Val Lys Ala Ser 450 455 460 tcc aca ggc act gag tcc tca gat gac ttt gag gag cga gac cct gac 1440 Ser Thr Gly Thr Glu Ser Ser Asp Asp Phe Glu Glu Arg Asp Pro Asp 465 470 475 475 480 ctg gga gac ggg ctg gag aat ggg ctg ggc agc ccctt aag tgg 1488 Leu Gly Asp Gly Leu Glu Asn Gly Leu Gly Ser Pro Phe Gly Lys Trp 485 490 495 aca ctg tcc agc gcg gct cag acc cac cag ctg cgg cga ctg cgg ggc 1536 Thr Leu Ser Ser Ala Ala Gln Thr His Gln Le Arg Arg Leu Arg Gly 500 505 510 cca gcc aag tgc cgc gag tgc gaa gcc ttc atg gtc agc ggg acg gag 1584 Pro Ala Lys Cys Arg Glu Cys Glu Ala Phe Met Val Ser Gly Thr Glu 515 520 525 tgt gtt gag tg acc tgc cac aag cgc tgc ctg gag act ctc 1632 Cys Glu Glu Cys Phe Leu Thr Cys His Lys Arg Cys Leu Glu Thr Leu 530 535 540 ctg atc ctc tgt gga cac agg cgg ctc cca gcc cgg aca ccc ctt ttt 1680 Ile Leu Cys Gly His Arg Arg Leu Pro Ala Arg Thr Pro Leu Phe 545 550 555 560 ggg gtt gac ttc ctg cag cta ccc agg gac ttc ccg gag gag gta ccc 1728 Gly Val Asp Phe Leu Gln Leu Pro Arg Asp Phe Pro Glu Val Pro 565 570 575 ttt gtg gtc acg aag tgc acg gct gag ata gaa cac cgt gcc ctg gat 1776 Phe Val Val Thr Lys Cys Thr Ala Glu Ile Glu His Arg Ala Leu Asp 580 585 590 gtg cag ggc att tacggg gc tcc cgg gtc cgt gtg gag cgg 1824 Val Gln Gly Ile Tyr Arg Val Ser Gly Ser Arg Val Arg Val Glu Arg 595 600 605 ctg tgc cag gct ttc gag aat ggc cga gcg ttg gtg gag ctg tcg ggg 1872 Leu Cy Glu Asn Gly Arg Ala Leu Val Glu Leu Ser Gly 610 615 620 aac tcg cct cat gac gtc tcg agt gtc ctc aag cga ttt ctt cag gag 1920 Asn Ser Pro His Asp Val Ser Ser Val Leu Lys Arg Phe Leu Gln Glu 625 630 630 630 640 ctc acc gag ccc gtg atc ccc ttc cac ctc tac gac gcc ttc atc tct 1968 Leu Thr Glu Pro Val Ile Pro Phe His Leu Tyr Asp Ala Phe Ile Ser 645 650 655 ctg gct aag acc ttg cat gca gac cct ggg gac gac c ct ggg acc ccc 2016 Leu Ala Lys Thr Leu His Ala Asp Pro Gly Asp Asp Pro Gly Thr Pro 660 665 670 agc ccc agc cct gag gtt atc cgc tcg ctg aag acc ctc ttg gta cag 2064 Ser Pro Ser Pro Glu Val Ile Arg Ser Leu Lys Thr Leu Leu Val Gln 675 680 685 ctg cct gac tct aac tac aac acc ctg cgg cac ctg gtg gcc cat ctg 2112 Leu Pro Asp Ser Asn Tyr Asn Thr Leu Arg His Leu Val Ala His Leu 690 695 700 ttc agg gtg gct gca cga ttt atg gaa aac aag atg tct gcc aac aac 2160 Phe Arg Val Ala Ala Arg Phe Met Glu Asn Lys Met Ser Ala Asn Asn 705 710 715 715 720 ctg ggc att gtg ttt ggg ccg aca ctg ctg cgg Leccly c197 Val Phe Gly Pro Thr Leu Leu Arg Pro 725 730 <210> 110 <211> 3813 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (642) .. (2303) <400> 110 catatatttt gcttgaagtg agtgattttc aaactttttg tatttggtgg gctgtccatc 60 ttgtaatggt gggagtaaat gtttccatag atgataaggc agttcttggc tgaattcagc 120 ttgtgtttct tttggagggt gggcaaatca gagggcagag attatttagt tgcattatag 180 gtattcttct ataccacttg ccctttgaaa ccctcaactt gaggtaatgt gcagtctggg 240 gttttaatta gtattaataa tcttgtggat ttacagaaat ctataatgca cagagttgag 300 ttttaaccaa tgatcgtatt catagaaaat atttcgaacc accacattct tcatggtcat 360 tttagttagt acatagtcat tgagtggcca gccacacctg acacaatctc ccagcatcca 420 agattggaga ttcctggtct gtgtagagta tatggttttg cacgaaatct ttctagtctt 480 gtgattgctt cagtttaatt tgtcacataa aaccacaagt atttaatatt aatgtatcag 540 tggtttggtg tttttgttcc cagtactggg ctttgcgccg ggaaaaatct gaatactgga 600 gctacagagt taactctaaa agtgctttta ttggtttcta g aaa ctg gaa gaa gag 656 Lys Leu Glu Glu Glu 1 5 aaa ggc aaa aag gaa aaa gaa aga cag gaa att gag aaa gaa cgg aga 704 Lys Gly Lys Lys Glu Lys Glu Arg Gln Glu Ile Glu Lys Glu Arg Arg 10 15 20 gaa aga gag agg gag cgt gaa agg gaa cga gaa agg cga gaa cgg gaa 752 Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Arg Glu Arg Glu 25 30 35 cga gaa agg gaa aga gaa cgt gaa cga gaa aag gag aaa gaa cgg gag 800 Arg Glu Arg Glu Arg Glu Arg Glu Glu Lys Glu Arg Glu 40 45 50 cgg gaa cga gaa cgg gat agg gac cgt gac cgg aca aaa gag aga gac 848 Arg Glu Arg Glu Arg Asp Arg Asp Arg Asp Arg Thr Lys Glu Arg Asp 55 60 65 cga gat cgg gat cga gag aga gat cgt gac cgg gat aga gaa agg agc 896 Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp Arg Asp Arg Glu Arg Ser 70 75 80 85 tca gat cgt aat aag gat cgc agt cga tca aga gaa aaa agc aga gat 944 Ser Arg Asn Lys Asp Arg Ser Arg Ser Arg Glu Lys Ser Arg Asp 90 95 100 cgt gaa agg gaa cga gag cgg gaa aga gag aga gag aga gaa cga gag 992 Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 105 110 115 cga gaa cga gaa cgg gag cga gag aga gag cga gag agg gaa cgg gag 1040 Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 120 125 130 cga gaa aga gaa aaa gac aaa aaa cgg gac gaa gaa gat ga a gaa 1088 Arg Glu Arg Glu Lys Asp Lys Lys Arg Asp Arg Glu Glu Asp Glu Glu 135 140 145 gat gca tac gaa cga aga aaa aaa ctt gaa aga aaa ctc cga gag aaa gaa 1136 Asp Ala Tyr Glu Arg Arg Lys Leu Glu Leu Arg Glu Lys Glu 150 155 160 165 gct gct tat caa gag cgc ctt aag aat tgg gaa atc aga gaa cga aag 1184 Ala Ala Tyr Gln Glu Arg Leu Lys Asn Trp Glu Ile Arg Glu Arg Lys 170 175 180 aaa acc cgg gaa gag aaa gaa gct gaa aga gaa gaa gaa aga aga 1232 Lys Thr Arg Glu Tyr Glu Lys Glu Ala Glu Arg Glu Glu Glu Arg Arg 185 190 195 aga gaa atg gcc aaa gaa gct aaa cga cta aaa gaa ttctta gaa ttctta Met Ala Lys Glu Ala Lys Arg Leu Lys Glu Phe Leu Glu Asp 200 205 210 tat gat gat gat aga gat gac ccc aaa tat tac aga gga agt gct ctt 1328 Tyr Asp Asp Asp Arg Asp Asp Pro Lys Tyr Tyr Arg Gly Ser Ala Leu 215 220 225 cag aaa agg ttg cgt gat aga gaa aag gaa atg gaa gca gat gaa cga 1376 Gln Lys Arg Leu Arg Asp Arg Glu Lys Glu Met Glu Ala Asp Glu Arg 230 235 240 245 gat agg aag aga gag aag gag tt gag gaa atc agg cag cgc ctt 1424 Asp Arg Lys Arg Glu Lys Glu Glu Leu Glu Glu Ile Arg Gln Arg Leu 250 255 260 ctg gca gaa ggg cat cca gat cca gat gca gag ctc cag agg atg gaa 1472 Leu Ala Glu Pro Asp Pro Asp Ala Glu Leu Gln Arg Met Glu 265 270 275 caa gag gct gag agg cgc agg cag cca caa ata aag caa gag cca gaa 1520 Gln Glu Ala Glu Arg Arg Arg Gln Pro Gln Ile Lys Gln Glu Pro Glu 280 285 285 tca gaa gag gag gaa gaa aag caa gaa aaa gaa gaa aaa cga gaa 1568 Ser Glu Glu Glu Glu Glu Glu Lys Gln Glu Lys Glu Glu Lys Arg Glu 295 300 305 gaa ccc atg gaa gag gag gag gag gag gag gag cag at ctg aaa 1616 Glu Pro Met Glu Glu Glu Glu Glu Pro Glu Gln Lys Pro Cys Leu Lys 310 315 320 325 cct act ctg agg ccc atc agc tct gct cca tct gtt tcc tct gcc agt 1664 Pro Thr Leu Arg Pro Ile Ser Ser Ala Pro Ser Val Ser Ser Ala Ser 330 335 340 ggc aat gca aca cct aac act cct ggg gat gag tct ccc tgt ggt att 1712 Gly Asn Ala Thr Pro Asn Thr Pro Gly Asp Glu Ser Pro Cys Gly Ile 345 350 355 att att cct ca t gaa aac tca cca gat caa cag caa cct gag gag cat 1760 Ile Ile Pro His Glu Asn Ser Pro Asp Gln Gln Gln Pro Glu Glu His 360 365 370 agg cca aaa ata gga cta agt ctt aaa ctg ggt gct tcc aat agt cct 1808 Arg Pro Lys Ile Gly Leu Ser Leu Lys Leu Gly Ala Ser Asn Ser Pro 375 380 385 ggt cag cct aat tct gtg aag aga aag aaa cta cct gta gat agt gtc 1856 Gly Gln Pro Asn Ser Val Lys Arg Lys Lys Leu Pro Val Asp Ser Val 390 395 400 405 ttt aac aaa ttt gag gat gaa gac agt gat gac gta ccc cga aaa agg 1904 Phe Asn Lys Phe Glu Asp Glu Asp Ser Asp Asp Val Pro Arg Lys Arg 410 415 420 aaa ctg gtt ccc ttg gat tat ggt gaa gat gat aaa aat gca acc aaa 1952 Lys Leu Val Pro Leu Asp Tyr Gly Glu Asp Asp Lys Asn Ala Thr Lys 425 430 435 ggc act gta aac act gaa gaa aag cgt aaa cac att aag agt ctc att 2000 Gly Thr Val Asn Thr Glu Glu Lys Arg Lys His Ile Lys Ser Leu Ile 440 445 450 gag aaa atc cct aca gcc aaa cct gag ctc ttc gct tat ccc ctg gat 2048 Glu Lys Ile Pro Thr Ala Lys Pro Glu Leu Phe Ala Tyr Pro Leu Asp 455 46 0 465 tgg tct att gtg gat tct ata ctg atg gaa cgt cga att aga cca tgg 2096 Trp Ser Ile Val Asp Ser Ile Leu Met Glu Arg Arg Ile Arg Pro Trp 470 475 480 485 att aat aag aaa atc ata gaa tat ata ggt gaa gaa gct aca tta 2144 Ile Asn Lys Lys Ile Ile Glu Tyr Ile Gly Glu Glu Glu Ala Thr Leu 490 495 500 gtt gat ttt gtt tgt tct aag gtt atg gct cat agt tca ccc cag agc 2192 Val Asp Phe Val Cys Ser Lys Val Met Ala His Ser Ser Pro Gln Ser 505 510 515 att tta gat gat gtt gcc atg gta ctt gat gaa gaa gca gaa gtt ttt 2240 Ile Leu Asp Asp Val Ala Met Val Leu Asp Glu Glu Ala Glu Val Phe 520 525 530 ata gtc aaa atg tgg aga tta ttg ata tat gaa aca gaa gcc aag aaa 2288 Ile Val Lys Met Trp Arg Leu Leu Ile Tyr Glu Thr Glu Ala Lys Lys 535 540 545 att ggt ctt gtg aag taaaactttt tatatttaga gttcctcgtcctcgtcctcgccctcgccc ttttaaggac tttgaatttt tctttgtctt tgaagacatt gtgagatctg 2403 taattttttt tttttgtaga aaatgtgaat tttttggtcc tctaatttgt tgttgccctg 2463 tgtactccct tggttgtaaa gtcatctg aa tccttggttc tctttatact caccaggtac 2523 aaattactgg tatgttttat aagccgcagc tactgtacac agcctatctg atataatctt 2583 gttctgctga tttgtttctt gtaaatatta aaacgactcc ccaattattt tgcagaattg 2643 cacttaatat tgaaatgtac tgtataggaa ccaacatgaa caattttaat tgaaaacacc 2703 agtcataaac tattaccacc cccactctct tttgatcaga aatggcaagc ccttgtgaag 2763 gcatggagtt taaaattgga atgcaaaaat tagcagacaa tccattccta ctgtatttct 2823 gtatgaatgt gtttgtgaat gtatgtgtaa aagtctttct tttccctaat ttgctttggt 2883 ggggtcctta aaacatttcc caactaaaga atagaattgt aaaggaaaag tggtactgtt 2943 ccaacctgaa atgtctgtta taattaggtt attagtttcc cagagcatgg tgttctcgtg 3003 tcgtgagcaa tgtggtttgc taactggatg gggttttctt attaataaga tggctgcttc 3063 agcttctctt ttaaaggaat gtggatcata gtgatttttc cttttaattt tattgctcag 3123 aaatgaggca tatcctaaaa atcctggaga gctgtattta atgcattttt gcactaattg 3183 gtccttagtt taattctatt gtatctgttt atttaacaaa aaattcatca taccaaaaag 3243 tgtaagtgaa aacccccttt aaaacaaaac aaaaaaatga aataaaatta ggcaaattga 3303 cagacagtga gagttttaca aacatgatag gt attctgct cggcaatttg taagtttaca 3363 tgttatttaa ggataaaggt aaatcattca aggcagttac caaccactaa ctatttgttt 3423 tcatttttgt cttgtagaag gtttatatct tgttttacct tggctcatta gtgtttaaaa 3483 atgtactgat gatgtgctta gagaaattcc tggggctttc ttcgttgtag atcagaattt 3543 caccagggag taaaattacc tgaaaacgta agaagtttta aacagctttt cacacaaatt 3603 agatgcaact gttcccatgt ctgagtactt atttaaaaga aaggtaaaga ttggcctgtt 3663 agaaaaagca taatgtgagc tttggattac tggatttttt ttttttttaa acacacctgg 3723 agaggacatt tgaaaacact gttcttaccc tcgaaccctg atgtggttcc attatgtaaa 3783 tatttcaaat attaaaaatg tatatatttg 3813 <210> 111 <211> 4671 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1593) .. (3998) <400> 111 ttttaagatc catgagatga tcagacaaga aattttggag caggtcctca acagggttgt 60 taccagagca tcttctccca tcagtcattt cttagacctg ctttcaaata tcgtcatgta 120 tgcaccctta gttcttcaaa gttgttcttc taaagtcaca gaagcttttg actatttgtc 180 ctttctgccc cttcagactg tacaaaggct gcttaaggca gtgcagcccc ttctcaaagt 240 cagcatgtca atgagagact gcttgatact tgtccttcgg aaagctatgt ttgccaagta 300 tgtagcatct ttttctatca taggaagacg ttgtcttcta atgttggagc taaagttatc 360 tctgccatct cctagtacca cctgttcaca gtgatcatga gaattcctag ccccgcagag 420 caatttcatc aaataaggca ttttgctaag tgctttatgt gcttttttca tttagtcttc 480 agagcaaccc tatgaagtaa gaattattgc aattcccatt ttacagataa gaaaagttag 540 gcttagagaa gatgagtgac tttccaaaag taaaacagta gttggtggtg gagcaaggat 600 tcaaagtcag gtctaacatc agagcttgtg atgtcaagta ctttgctcta ctacattaga 660 ataatcttca gggtaatgtt ctagtgtcaa atactctgaa acctgagctg gcagcagttc 720 caaaggggaa agtaccttag tcaagaagat tatacttaag aatctcattt tagtgaacat 780 ctgaattatg atctagaggc tagtagatca aattaattgt tgaggggaat gagttttatt 840 tgtagcttag ccagtccctc ctaacatctc ttcctttatt tcttagtata taagctagag 900 atgatcttgc catctcctaa aaatataaga cagtaatatg tgaaaagcat ttggtacttt 960 gaggataaga tgcccaatta atatcacatt ggccatatta taatatattc atgggtgtcc 1020 agaggaacaa ctaagccata tgctattatc tttgttctag aattaaaagt ttttgttact 1080 cctcacccaa aggcatagcg aatagactga gatattacgt tgtaacatct ttaacatgaa 1140 ttaatcattg cgcctcagtg agaagacaag tgtgacattt tctggatgga cagtttacat 1200 ggcatcaaat attacattat cctatgatga aagagagcat atgaagggaa gcactccttc 1260 aaacatggca aaatcagcaa tttcttacat ttgagtaacc agccaatttt acagtctctc 1320 agcagtcttc ttattcctca catagacttg agagcaggat agaaggaagt agagtatcat 1380 gagttaagta ttgaaaaaag tcagttgaat ttctgtacta taaattgctt tgaacagctg 1440 ataccttatt ttgagtacat aaattcactt tgttttgctc tacgcttcat tgtttataca 1500 tatgccttct ctgtatgcaa ctagctggat ttttctgacc cagaagcata ttcctgtgaa 1560 atagtactgt ttgttaactt ctctatttct ga gct agc cag ctt gat gcc cga 1613 Ala Ser Gln Leu Asp Ala Arg 1 5 aaa tct gca gtt gct ggg ttt ttg ctg ctc ctg aag aac ttt aa a gtt 1661 Lys Ser Ala Val Ala Gly Phe Leu Leu Leu Leu Lys Asn Phe Lys Val 10 15 20 tta ggc agc ctg tca tcc tct cag tgc agt cag tct ctc agt gtc agt 1709 Leu Gly Ser Leu Ser Ser Ser Gln Cys Ser Gln Ser Leu Ser Val Ser 25 30 35 cag gtt cat gtg gat gtt cac agc cat tac aat tct gtc gcc aat gaa 1757 Gln Val His Val Asp Val His Ser His Tyr Asn Ser Val Ala Asn Glu 40 45 50 55 act ttt tgc ctt gag atc atg gat agt ttg agg aga tgc tta agc cag 1805 Thr Phe Cys Leu Glu Ile Met Asp Ser Leu Arg Arg Cys Leu Ser Gln 60 65 70 caa gct gat gtt cga ctc atg ctt tat gag ggg ttt tat gat gtt ctt 1853 Gln Aln Asp Val Arg Leu Met Leu Tyr Glu Gly Phe Tyr Asp Val Leu 75 80 85 cga agg aac tct cag ctg gct aat tca gtc atg caa act ctg ctc tca 1901 Arg Arg Asg Ser Gln Leu Ala Asn Ser Val Met Gln Thr Leu Leu Ser Ser 90 95 100 cag tta aaa cag ttc tat gag cca aaa cct gat ctg ctg cct cct ctg 1949 Gln Leu Lys Gln Phe Tyr Glu Pro Lys Pro Asp Leu Leu Pro Pro Leu 105 110 115 aaa tta gaa gct tgt att ctg acc caa gga gat aag atc tct c ta caa 1997 Lys Leu Glu Ala Cys Ile Leu Thr Gln Gly Asp Lys Ile Ser Leu Gln 120 125 130 135 gaa cca ctg gat tat ctg ctg tgt tgt att cag cat tgt ttg gcc tgg 2045 Glu Pro Leu Asp Tyr Leu Leu Cys Cys Ile Gln His Cys Leu Ala Trp 140 145 150 tat aag aat aca gtc ata ccc tta cag cag gga gag gag gaa gag gag 2093 Tyr Lys Asn Thr Val Ile Pro Leu Gln Gln Gly Glu Glu Glu Glu Glu 155 160 165 gag gaa gag gcattc tac gaa gac cta gat gat ata ttg gag tcc att 2141 Glu Glu Glu Ala Phe Tyr Glu Asp Leu Asp Asp Ile Leu Glu Ser Ile 170 175 180 act aat aga atg att aag agt gag ctg gaa gac ttt gaa ctg Asat aaa 2 Arg Met Ile Lys Ser Glu Leu Glu Asp Phe Glu Leu Asp Lys 185 190 195 tca gca gat ttt tct cag agc acc agt att ggc ata aaa aat aat atc 2237 Ser Ala Asp Phe Ser Gln Ser Thr Ser Ile Gly Ile Lys Asn Asn Ile 200 205 210 215 tct gct ttt ctt gtg atg gga gtt tgt gag gtt tta ata gaa tac aat 2285 Ser Ala Phe Leu Val Met Gly Val Cys Glu Val Leu Ile Glu Tyr Asn 220 225 230 ttc tcc ata agt agt ttc agt aag ag a at agg ttt gag gac att ctg agc 2333 Phe Ser Ile Ser Ser Phe Ser Lys Asn Arg Phe Glu Asp Ile Leu Ser 235 240 245 tta ttt atg tgt tac aaa aaa ctc tct gac att ctt aat gaa aaa gcg 2381 Leu Phe Met Cysyr Lys Lys Leu Ser Asp Ile Leu Asn Glu Lys Ala 250 255 260 ggt aaa gcc aaa act aaa atg gcc aac aag aca agt gat agt ctt ttg 2429 Gly Lys Ala Lys Thr Lys Met Ala Asn Lys Thr Ser Asp Ser Leu Leu 265 270 275 tcc atg aaa ttt gtg tcc agt ctt ctc act gct ctt ttc agg gat agt 2477 Ser Met Lys Phe Val Ser Ser Leu Leu Thr Ala Leu Phe Arg Asp Ser 280 285 290 290 295 atc caa agc cac caa gaa agc ctt tct gtt ccc agg agc aat gag 2525 Ile Gln Ser His Gln Glu Ser Leu Ser Val Leu Arg Ser Ser Asn Glu 300 305 310 ttt atg cgc tat gca gtg aat gta gct ctg cag aaa gta cag cag cta 2573 Phe Met Arg Tyr Ala Val Asn Val Ala Leu Gln Lys Val Gln Gln Leu 315 320 325 aag gaa aca ggg cat gtg agt ggc cct gat ggc caa aac cca gaa aag 2621 Lys Glu Thr Gly His Val Ser Gly Pro Asp Gly Gln Asn Pro Glu Lys 330 335 340 atc ttt cag aa c ctc tgt gac tta act cga gtc ttg cta tgg aga tac 2669 Ile Phe Gln Asn Leu Cys Asp Leu Thr Arg Val Leu Leu Trp Arg Tyr 345 350 355 act tca att cct act tca gtg gaa gag tcg gga aag aaa gag aaa gga 2 Thr Ser Ile Pro Thr Ser Val Glu Glu Ser Gly Lys Lys Glu Lys Gly 360 365 370 375 aag ag agc atc tca ctg ctg tgc ttg gag ggt tta cag aaa ata ttc agt 2765 Lys Ser Ile Ser Leu Leu Cys Leu Glu Gly Leu Gln Lys Ile Phe Ser 380 385 390 gct gtg caa cag ttc tat cag ccc aag att cag cag ttt ctc aga gct 2813 Ala Val Gln Gln Phe Tyr Gln Pro Lys Ile Gln Gln Phe Leu Arg Ala 395 400 405 ctg gat gtc aca gat aga gag gaa gag aga gaa gat gca gat gtc 2861 Leu Asp Val Thr Asp Lys Glu Gly Glu Glu Arg Glu Asp Ala Asp Val 410 415 420 agt gtc act cag aga aca gca ttc cag atc cgg caa ttt cag agg tcc 2909 Ser Val Thr Gln Arg Thr Ala Phe Gln Ile Arg Gln Phe Gln Arg Ser 425 430 435 ttg ttg aat tta ctt agc agt caa gag gaa gat ttt aat agc aaa gaa 2957 Leu Leu Asn Leu Leu Ser Ser Gln Glu Glu Asp Phe Asn Ser Lys Glu 440 5 450 455 gcc ctc ctg cta gtc acg gtt ctt acc agt ttg tcc aag tta ctg gag 3005 Ala Leu Leu Leu Val Thr Val Leu Thr Ser Leu Ser Lys Leu Leu Glu 460 465 470 ccc tcc tct cct cag ttt gtg cag atg ttacc tgg aca tca aag att 3053 Pro Ser Ser Pro Gln Phe Val Gln Met Leu Ser Trp Thr Ser Lys Ile 475 480 485 tgc aag gaa aac agc cgg gag gat gcc ttg ttt tgc aag agc ttg atg 3101 Cys Lys Glu Asn Ser Arg Glu Asp Ala Leu Phe Cys Lys Ser Leu Met 490 495 500 aac ttg ctc ttc agc ctg cat gtt tcg tat aag agt cct gtc att ctg 3149 Asn Leu Leu Phe Ser Leu His Val Ser Tyr Lys Ser Pro Val Ile Leu 505 510 515 ctg cgt ttg tcc cag gat atc cac ggg cat ctg gga gat ata gac 3197 Leu Arg Asp Leu Ser Gln Asp Ile His Gly His Leu Gly Asp Ile Asp 520 525 530 530 535 cag gat gta gag gtg gag aaa aca aac aac cac ttt gca ata gtg atg 3245 Gln Asp Val Glu Val Glu Lys Thr Asn His Phe Ala Ile Val Asn Leu 540 545 550 aga acg gct gcc ccc act gtc tgt tta ctt gtt ctg agt cag gcc gag 3293 Arg Thr Ala Ala Pro Thr Val Cys Leu Leu Val Le u Ser Gln Ala Glu 555 560 565 aag gtt cta gaa gaa gtg gac tgg cta atc acc aag ctt aag gga caa 3341 Lys Val Leu Glu Glu Val Asp Trp Leu Ile Thr Lys Leu Lys Gly Gln 570 575 580 580 gtg agc caa gaa acc tca gaa gag gcc tct tct cag gca acc cta 3389 Val Ser Gln Glu Thr Leu Ser Glu Glu Ala Ser Ser Gln Ala Thr Leu 585 590 595 cca aat cag cct gtt gag aaa gct atc atc atg caa ctg gga act ctg 3437 Pro Asn Gln Pro Val Glu Lys Ala Ile Ile Met Gln Leu Gly Thr Leu 600 605 610 615 ctt aca ttt ttc cac gag ctg gtg cag aca gct ctg cca tca ggc agc 3485 Leu Thr Phe Phe His Glu Leu Val Gln Thr Ala Leu Pro Ser Gly Ser 620 625 630 tgt gtg gac acc ttg tta aag gac ttg tgc aaa atg tac acc aca ctt 3533 Cys Val Asp Thr Leu Leu Lys Asp Leu Cys Lys Met Tyr Thr Thr Leu 635 640 645 aca gcc ctt gtc aga tat tat ctcgt gt cag agc tcc gga gga 3581 Thr Ala Leu Val Arg Tyr Tyr Leu Gln Val Cys Gln Ser Ser Gly Gly 650 655 660 att cca aaa aat atg gaa aag ctg gtg aag ctg tct ggt tct cat ctg 3629 Ile Pro Lys Asn Met Glu Ly s Leu Val Lys Leu Ser Gly Ser His Leu 665 670 675 acc ccc ctg tgt tat tct ttc att tct tac gta cag aat aag agt aag 3677 Thr Pro Leu Cys Tyr Ser Phe Ile Ser Tyr Val Gln Asn Lys Ser Lys 680 685 690 695 agc ctg aac tat acg gga gag aaa aag gag aaa cct gct gcc gtt gcc 3725 Ser Leu Asn Tyr Thr Gly Glu Lys Lys Glu Lys Pro Ala Ala Val Ala 700 705 710 aca gcc atg gcc aga gtt ctt cgg gaa acc aag cca atcct aac ctc 3773 Thr Ala Met Ala Arg Val Leu Arg Glu Thr Lys Pro Ile Pro Asn Leu 715 720 725 atc ttt gcc ata gaa cag tat gaa aaa ttt ctc atc cac ctt tct aag 3821 Ile Phe Ala Ile Glu Gln Tyr Glu Lys Phe Leu Ile His Leu Ser Lys 730 735 740 aag tcc aag gtg aac ctg atg cag cac atg aag ctc agc acc tca cga 3869 Lys Ser Lys Val Asn Leu Met Gln His Met Lys Leu Ser Thr Ser Arg 745 750 755 gac ttc aag atc aaa gga aac atc cta gac atg gtt ctt cga gag gat 3917 Asp Phe Lys Ile Lys Gly Asn Ile Leu Asp Met Val Leu Arg Glu Asp 760 765 770 775 ggc gaa gat gaa aat gaa gag ggc act gca tca gag cat ggg gga cag 3 Glu Asp Glu Asn Glu Glu Gly Thr Ala Ser Glu His Gly Gly Gln 780 785 790 aac aaa gaa cca gcc aag aag aaa agg aaa aaa taaatgaaat gcctgagtta 4018 Asn Lys Glu Pro Ala Lys Lys Lys Arg Lys Lys 795 tca tca tct gatca tct gatca tct cccttgtcct 4078 gtagtccaca ccgatgttgg catcttggtt ctgaacccac tgaattcaac tgcaccttca 4138 gttagaagga atcttcttgg caggtcctgc tactgaaaaa tggctggcct taggcaagcc 4198 cttttgcaaa aagcacagct gaaagcctga gtttgggagc ctgcacccac cccgatgaag 4258 ctccacggga gcaaatacag agcctccagg cagtgctatg gtccaggctg gcttcgtttt 4318 tccaaggagc ctttggtgag ttcaattatc tggtaaatat ccagcgcttc acctgaaaga 4378 tagtgcaaat tggttaggat gccacctcaa gaactgtaac tgagagctca gaagtgagca 4438 aaggagctta atgctaaggt caaaaggaga gtgaaaggtt gagaacaatt gccacgaacg 4498 gtaatgttac atgttaggag ggtctgtttt ctttttatat aagtgtgtct tagatatatt 4558 ttaaatagaa aataagcttt ctgatttact tgtttgggg ttaaagcaca gtttgttttt 4618 ctgtcaccta tagagtgcaa gaatgc aatct tatagaataatct <210> 112 <211> 3936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (144) .. (2393) <400> 112 cttccgctcg gggactgagg ttgctgcagt ttttccgcga tagtttgggg cagttccgcg 60 cgttgcaggc ccttctgaat ttcctggacc tacgcattgg atcctcaaag aactgctgaa 120 taccactaga aacatcg Tag cag gag tag cag g ag tag cca gag tag cg g acc agg ggc tgt ctt ggc aca att ctg ctt tcc 221 Gln Gly Ser Pro Arg Thr Arg Gly Cys Leu Gly Thr Ile Leu Leu Ser 15 20 25 cag gaa ctg cat cac tca gga ctc tgc aag ttt cca gaa gta aga ggg Glu Glu Glu Leu His His Ser Gly Leu Cys Lys Phe Pro Glu Val Arg Gly 30 35 40 aaa atg acc acg ttc aag gag gca atg acc ttc aag gac gtg gct gtg 317 Lys Met Thr Thr Phe Lys Glu Ala Met Thr Phe Lys Asp Val Ala Val 45 50 55 gtc ttc act gag gaa gag ctg ggg ctg ctg gac ctt gct cag agg aag 365 Val Phe Thr Glu Glu Glu Leu Gly Leu Leu Asp Leu Ala Gln Arg Lys 60 65 70 ctg tat cga gat gtg atg ctg gag aactt aac ctg ctc tca gtg 413 Leu Tyr Arg Asp Val Met Leu Glu Asn Phe Arg Asn Leu Leu Ser Val 75 80 85 90 gga cat caa gca ttc cac a gg gat act ttc cac ttc cta agg gaa gaa 461 Gly His Gln Ala Phe His Arg Asp Thr Phe His Phe Leu Arg Glu Glu 95 100 105 aag att tgg atg atg aag aca gca atc caa agg gaa ggg aat tca gga 509 Lys Ile Trp Met Met Lys Thr Ala Ile Gln Arg Glu Gly Asn Ser Gly 110 115 120 gac aag atc caa act gag atg gag act gtt tca gaa gca gga aca cat 557 Asp Lys Ile Gln Thr Glu Met Glu Thr Val Ser Glu Ala Gly Thr His 125 130 135 caa gag tgg tcc ttc cag caa atc tgg gaa aaa att gca agt gat tta 605 Gln Glu Trp Ser Phe Gln Gln Ile Trp Glu Lys Ile Ala Ser Asp Leu 140 145 150 acc agg tct caa gac ttg atg ata aat agc tct cag ttc tcc aaa gaa 653 Thr Arg Ser Gln Asp Leu Met Ile Asn Ser Ser Gln Phe Ser Lys Glu 155 160 165 170 ggt gat ttc ccc tgc cag act gag gca gga cta tct gta att cac aca 701 Gly Asp Phe Pro Cys Gln Thr Glu Ala Gly Leu Ser Val Ile His Thr 175 180 185 aga cag aaa tct tcc cag ggc aat gga tat aaa cca tcc ttc agt gat 749 Arg Gln Lys Ser Ser Gln Gly Asn Gly Tyr Lys Pro Ser Phe Ser Asp 190 195 200 gtc tcc cac tt t gat ttt cat caa caa tta cac tca gga gag aaa tct 797 Val Ser His Phe Asp Phe His Gln Gln Leu His Ser Gly Glu Lys Ser 205 210 215 cat acg tgt gat gag tgt gga aag aac ttt tgt tac atc tca gcc ctt 845 His Thr Cys Asp Glu Cys Gly Lys Asn Phe Cys Tyr Ile Ser Ala Leu 220 225 230 cgt att cat cag aga gtc cac atg gga gag aaa tgc tat aag tgt gac 893 Arg Ile His Gln Arg Val His Met Gly Glu Lys Cys Tyr Lys Cys Asp 235 240 245 250 gtg tgt ggt aag gaa ttc agt cag agt tca cat ctg caa act cat cag 941 Val Cys Gly Lys Glu Phe Ser Gln Ser Ser His Leu Gln Thr His Gln 255 260 265 aga gtc cac act gga gag aaa ccg ttc aaa tgt gtg gaa tgt ggg aaa 989 Arg Val His Thr Gly Glu Lys Pro Phe Lys Cys Val Glu Cys Gly Lys 270 275 280 ggc ttc agt cgt aga tca gca ctt aat gtt cat cat aaa tta cac aca 1037 Gly Phe Ser Arg Arg Ser Ala Leu Asn Val His His Lys Leu His Thr 285 290 295 gga gag aaa cct tat aat tgt gag gaa tgc ggg aag gcc ttc att cac 1085 Gly Glu Lys Pro Tyr Asn Cys Glu Glu Cys Gly Lys Ala Phe Ile His 300 305 310gat tcc cag ctt caa gaa cat cag aga atc cat acg ggg gag aag cca 1133 Asp Ser Gln Leu Gln Glu His Gln Arg Ile His Thr Gly Glu Lys Pro 315 320 325 330 ttc aaa tgt gat ata tgt ggt aag agc ttc tgt ggt aga tca aga ctt 1181 Phe Lys Cys Asp Ile Cys Gly Lys Ser Phe Cys Gly Arg Ser Arg Leu 335 340 345 aat agg cat tcc atg gtt cac acg gca gag aaa cca ttc cga tgt gat 1229 Asn Arg His Ser Met Val His Thr Ala Glu Lys Pro Phe Arg Cys Asp 350 355 360 acg tgt gat aag agc ttt cgt cag aga tca gca ctt aat agt cat cgc 1277 Thr Cys Asp Lys Ser Phe Arg Gln Arg Ser Ala Leu Asn Ser His Arg 365 370 375 atg atc cac aca gga gag aaa cca tac aaa tgt gag gag tgt gga aaa 1325 Met Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys 380 385 390 ggc ttt att tgt agg cga gat ctt tat acg cat cat atg gtc cac acg 1373 Gly Phe Ile Cys Arg Arg Asp Leu Tyr Thr His His Met Val His Thr 395 400 405 410 gga gaa aag cca tat aat tgt aaa gag tgt ggg aag agc ttc aga tgg 1421 Gly Glu Lys Pro Tyr Asn Cys Lys Glu Cys Gly Lys Ser P he Arg Trp 415 420 425 gcc tcg tgt ctt ttg aaa cat cag cga gtc cac agt gga gaa aaa cca 1469 Ala Ser Cys Leu Leu Lys His Gln Arg Val His Ser Gly Glu Lys Pro 430 435 440 ttc aaa tgt gaa gaa tgt ggg gga ttt tac aca aat tca caa tgc 1517 Phe Lys Cys Glu Glu Cys Gly Lys Gly Phe Tyr Thr Asn Ser Gln Cys 445 450 455 tat tcc cac cag aga tcc cat agt gga gaa aaa cca tac aaa tgt gtg 1565 Tyr Ser His Gln Arg Ser His Ser Gly Glu Lys Pro Tyr Lys Cys Val 460 465 470 gag tgt ggg aag ggc tac aaa agg agg ttg gat ctt gac ttt cac cag 1613 Glu Cys Gly Lys Gly Tyr Lys Arg Arg Leu Asp Leu Asp Phe His Gln 475 480 485 490 cgc gtc cat aca gga gag aaa ctg tat aat tgt aag gaa tgt ggg aag 1661 Arg Val His Thr Gly Glu Lys Leu Tyr Asn Cys Lys Glu Cys Gly Lys 495 500 505 agc ttt agt cgg gcc cca tgt ctt ttg aga gag ctc cac agt 1709 Ser Phe Ser Arg Ala Pro Cys Leu Leu Lys His Glu Arg Leu His Ser 510 515 520 gga gaa aaa cca ttc caa tgt gaa gag tgt ggg aag aga ttt act caa 1757 Gly Glu Lys Pro Phe Gln Cys Glu Glu Cys Gly Lys Arg Phe Thr Gln 525 530 535 aat tca cat ctt cat tcc cat cag aga gtt cac act gga gaa aag cca 1805 Asn Ser His Leu His Ser His Gln Arg Val His Thr Gly Glu Lys Pro 540 545 550 tac aaa tgt gag aag tgt gga aag ggc tac aat agt aag ttt aat ctt 1853 Tyr Lys Cys Glu Lys Cys Gly Lys Gly Tyr Asn Ser Lys Phe Asn Leu 555 560 565 570 gat atg cac cag aag gtc cac aca gga gag aga cca tac at t 1901 Asp Met His Gln Lys Val His Thr Gly Glu Arg Pro Tyr Asn Cys Lys 575 580 585 gaa tgt ggg aag agt ttt ggc tgg gcc tcg tgt ctt ttg aaa cat cag 1949 Glu Cys Gly Lys Ser Phe Gly Trp Ala Ser Cys Leu Leu Lys His Gln 590 595 600 aga ctg cac agt gga gaa aaa cca ttc aaa tgt gaa gag tgt ggg aaa 1997 Arg Leu His Ser Gly Glu Lys Pro Phe Lys Cys Glu Glu Cys Gly Lys 605 610 615 aga ttt act cag aat tca cag ctt cat tct cat caa aga gtg cac act 2045 Arg Phe Thr Gln Asn Ser Gln Leu His Ser His Gln Arg Val His Thr 620 625 630 gga gaa aag cca tac aaa tgt gat gag tgt ggg aag ggc ttc agc tgg 2093 Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Gly Phe Ser Trp 635 640 645 650 tcc tca act cgt ctg acc cat cag aga cgc cac agc aga gaa aca cct 2141 Ser Ser Thr Arg Leu Thr His Gln Arg Arg His Ser Arg Glu Thr Pro 655 660 665 ctc aaa tgt gag cag cat ggg aag aac att gta cag aat tca ttc tct 2189 Leu Lys Cys Glu Gln His Gly Lys Asn Ile Val Gln Asn Ser Phe Ser 670 675 680 680 aaa gtg caa gaa aaa gtt cac agt gtaa cca tac aaa tgt gag 2237 Lys Val Gln Glu Lys Val His Ser Val Glu Lys Pro Tyr Lys Cys Glu 685 690 695 gac tgt ggg aag ggc tac aac agg cgc ttg aat ctt gat atg cat cag 2285 Asp Cys Gly Lys Gly Tyr Asn Arg Arg Leu Asn Leu Asp Met His Gln 700 705 710 agg gtc cac atg gga gag aaa aca tgg aag tgt agg gag tgt gat atg 2333 Arg Val His Met Gly Glu Lys Thr Trp Lys Cys Arg Glu Cys Asp Met 715 720 725 730 tgc ttt agt cag gcc tca agc ctt cga ctt cat cag aat gtt cat gtt 2381 Cys Phe Ser Gln Ala Ser Ser Leu Arg Leu His Gln Asn Val His Val 735 740 745 gga gaa aaa cct tagtgatgtg atggtgcaat aaagtcttca ctcagtctt c 2433 Gly Glu Lys Pro 750 atgaatgcag tctcatctga aagttcacaa aggagagaca cattaaaata tgaggcacat 2493 agtaagcact tccctttgag tattttatct ctgaatccat gctggtgata aatttcaccc 2553 attcttggaa gagggaaaac atttgtttaa gataacatca gtgcttcagc catagctcag 2613 catgccccag tagtctcagg accaccataa tggagaatcc ttgtaaatgg tgcaataaag 2673 cttcattcag aagtttgata attacagcta tcattcagga gacaggcctt agaaagagta 2733 agagttcatg aatttaccag actaatggtg gacatgtcca aattgatgtc cactagaatg 2793 taaactacat gtgtctttgc tgctaagtcg tcacagcctt aacattgatt agcactttgt 2853 atgtgttcag tacttgtttg ttaaatcaat gaaaggataa aacatatgta tggatttgga 2913 tacaattttg tgtatccaaa aagggaagcc tgcaaaaaat aattctggga aacatgagtt 2973 gaaatgcaga gtaaactcag tactgcaatc catagcaata ttttgcatat tattattttt 3033 tcttttaaat ttttttcttg atcagattta tcatattcat tgaacattat tttattgcac 3093 ttggctcctg gcttcccccc atcctgtgct ctgaagtcag agtattattt gtggctctat 3153 gaaatgtcca ttgcttgtat acggtataaa tttaattatc ttttgtagtt tttctcacag 3213 tatagactga aaaggtttgg ttaattttgc aataacagac cactg catat ttcacaatta 3273 agtgttttca acagtattaa ggcaagattt acagtaacac ttttaaagtg ccagatgtac 3333 attgacagaa attttcttag tcaatcctag attgatcatg atttgtgatt tctatgcagg 3393 ccttggtatg attgcctttt aattgctgta caatttcttt ttttttttta acttctctgg 3453 tataaaatat tctaaatttg aatgacagct tttgtcaacc ttcttatcca atattcttcc 3513 accaacgcta tgaaacagga agagaaaatg gagtttggta atttcatcaa atatattcat 3573 tattgggggc aggagtaaca tttaaatcct cctctttatt gctggcagta aaaatatgtc 3633 ttttggagag cagaacatgc cagaatgtat aaggtgcaac tgtttgatat gaaaaccata 3693 ggataggaaa ctatgcctat gacactaaaa ctccaaaaag tagaagacca cattgatgat 3753 gtcactgcat tttaaaatgg aaagaacaag tgttcaagaa caggaatttg tgtgaattgc 3813 atttattcct ataatat gaactcaatg agatcaatg agatcaatg agatcaatg agatcaatg agatcaatg agatcagut <210> 113 <211> 4729 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (518) .. (1540) <400> 113 gaggagaggc cggacggcgc gggcgccggc gaggagagcc cgcggctgca gggctgtgac 60 tccctgacgc agatccagtg cggccagctg cagagccgca gggcccagat tcaccagcag 120 attgacaagg agctgcagat gcggacgggc gctgagaacc tctacagagc caccagcaac 180 aaccgggtga gagagacggt cgccctggag ctgagctacg tcaactccaa cctgcagctg 240 ctgaaggagg agctggagga gctcagcggt ggcgtggacc ctggccggca tgggagcgaa 300 gctgtcactg tccccatgat ccccctgggc ctgaaggaga ccaaggagct ggactggtct 360 acaccgctga aggagctgat ctcagtgcac tttggagagg acggcgcctc ctacgaggca 420 gaaatcaggg agctggaggc cctgcggcag gtgtgtggtt cccccgccca cccaccctcc 480 tgcagccctg ggagacacat gcagaggctg aagctga agt cag gaa cag aca gag gc gg gg gc gg gc Thr Glu Gc gg gg gc gg gc gg gc gc gg gc gg gc gg gc Asp Ile Ser Arg Thr Trp Gly Asp Gly Arg Thr Arg 10 15 20 ggc cct gtg tgt cca gac cca gcc agg ggg cgt gga ggg gct ccc agg 631 Gly Pro Val Cys Pro Asp Pro Ala Arg Gly Arg Gly Gly Ala Pro Arg 25 30 35 tgg ctc cgg tgc cgc atg ctg ctg gcc ttc ggg agt cac ggc tgc cca 679 Trp Leu Arg Cys Arg Met Leu Leu Ala Phe Gly Ser His Gly Cys Pro 40 45 50 ggg ccc cac tgg ctt tgc ctc ccc gcc ccc cat ggt gct ggt gcc cat 727 Gly Pro His Trp Leu Cys Leu Pro Ala Pro His Gly Ala Gly Ala His 55 60 65 70 ggg act tcc cag ggc agt gtg tgt gag tgg ggt ggg cca ggg cgg tgg 775 Gly Thr Ser Gln Gly Ser Val Cys Glu Trp Gly Gly Pro Gly Arg Trp 75 80 85 ggc cca gtg gct cct gcc ctg cag gcc atg cgg acc ccc agc cgg aat 823 Gly Pro Val Ala Pro Ala Leu Gln Ala Met Arg Thr Pro Ser Arg Asn 90 95 100 gag tcg ggc ctg gag ctg ctc aca gcc tat tac aac cag ctg tgc ttc 87 Ser Gly Leu Glu Leu Leu Thr Ala Tyr Tyr Asn Gln Leu Cys Phe 105 110 115 ctg gat gcg cgc ttc ctc acc cct gcc agg agc ctc ggg ctc ttc ttc 919 Leu Asp Ala Arg Phe Leu Thr Pro Ala Arg Ser Leu Gly Phe 120 125 130 cac tgg tac gac tcg ctt act ggg gtc ccg gcc cag cag cgt gcc ctg 967 His Trp Tyr Asp Ser Leu Thr Gly Val Pro Ala Gln Gln Arg Ala Leu 135 140 145 150 gcc ttc gag aag ggc agc gtt ctc ttc aac atc g gt gcc ctc cac acg 1015 Ala Phe Glu Lys Gly Ser Val Leu Phe Asn Ile Gly Ala Leu His Thr 155 160 165 cag att ggg gcg cgc cag gac cgc tcc tgc acc gag ggt gcc cgc cgc 1063 Gln Ile Gly Ala Arg Gln Ser Cys Thr Glu Gly Ala Arg Arg 170 175 180 gct atg gag gcc ttc cag agg gcc gct ggg gcc ttc agc ctc ctg agg 1111 Ala Met Glu Ala Phe Gln Arg Ala Ala Gly Ala Phe Ser Leu Leu Arg 185 190 195 gag aac tcc cat gcg ccg agc cca gac atg agc gct gcg tcc ctc 1159 Glu Asn Phe Ser His Ala Pro Ser Pro Asp Met Ser Ala Ala Ser Leu 200 205 210 tgc gca ctg gag cag ctc atg atg gcc cag gcc cag gaa 1gt gtg ttt Cys Ala Leu Glu Gln Leu Met Met Ala Gln Ala Gln Glu Cys Val Phe 215 220 225 230 gag ggc ctc tca cca cct gcc tcc atg gcc ccc caa gac tgc ctg gcc 1255 Glu Gly Leu Ser Pro Pro Ala Ser Met Ala Pro Gln Asp Cys Leu Ala 235 240 245 cag ctg cgc ctg gcg cag gag gcc gcc cag gtg agc tcg ggc acc cgt 1303 Gln Leu Arg Leu Ala Gln Glu Ala Ala Gln Val Ser Ser Gly Thr Arg 250 255 260 gtc agg atg cag ggg gtg g ccg agc tgg ggt cag agc cca ggt cca 1351 Val Arg Met Gln Gly Val Gly Pro Ser Trp Gly Gln Ser Pro Gly Pro 265 270 275 ggc atg cgt gag ctc tcc cac ctc ctt cct tgt gtg tca gcc ccg aetc 1399 Gly Glu Leu Ser His Leu Leu Pro Cys Val Ser Ala Pro Ser 280 285 290 cag ctg ttg tcc tgc tcc ctg ggg ggg ctg gtc agg aac ctg ggg acc 1447 Gln Leu Leu Ser Cys Ser Leu Gly Gly Leu Val Arg Asn Leu Gly Thr 295 300 305 310 cga gcc tct gcc tcc agg gga tgg cac aaa gca gca gga act gag gtg 1495 Arg Ala Ser Ala Ser Arg Gly Trp His Lys Ala Ala Gly Thr Glu Val 315 320 325 cca ggg agg ctg ctg gga tgg tgg tcg gag cag gtg gag gct ggg 1540 Pro Gly Arg Leu Leu Gly Trp Trp Ser Glu Gln Val Glu Ala Gly 330 335 340 tagggagaag caggcaccac ctggagagtg ggaggccctc gcgtgcctgc cacatccacc 1600 ggcaggtggc agccgagtac aggctagtgc accggaccat ggcccagcca cccgtccacg 1660 actacgtgcc tgtctcctgg actgccctgg tgcatgtcaa ggccgagtac ttccgctccc 1720 tggcccacta ccacgtagcc atggccctct gcgacggctc ccgtgagtgc ccaccgcact 1780 tgcccatggt actgccaag g cccccccgcg cagggctcac agcctctctg tcccccagca 1840 gcgaccgagg gagagctccc cacgcacgag caggtcttcc tgcagccccc cacctcctct 1900 aagccccgag gccctgtgct gccgcaggag ctggaggagc gcaggcagct tggtaaggcg 1960 cccatgggtg gagtgccctg gggctcagat ggtcaccaac ggtggcaggg tgtcccccac 2020 caccctcatg ctgtttgcca cctgctgtcc ccgtgctgac gagttgggcc acctacctat 2080 ccctggatgg cctgtgcctg atgggtgacg gcccagcgca ggggccccag gagtgctggg 2140 cagcctctga gcaggtggga gaccactggg agcagctcat ccctggcccc tgctttgcac 2200 gtggcagagc cctcctgcac agccagctcc tcacccccgt ggcgcgcacc cccaacgaaa 2260 gtggctgtga tgagccccac agccctggcg ttgcccactc cttctgccac gtcccagggc 2320 ccacgggccc acatggtgtg tgacatccca gtgccccgcg tgcaggcaag gcacacctga 2380 agcgtgccat cctggggcag gaggaggcgc tgcggctgca cgccctgtgc cgcgtcctgc 2440 gcgaggtgga cctgcttcgg gctgtgatct cccagacgct gcagcgctca ctggccaagt 2500 atgcggagct cgaccgtgag gatgacttct gtgaggctgc cgaggccccg gacatccagc 2560 ctaagaccca ccagaagcca gaggccagga tgccacgcct gtcccagggg aaggggcctg 2620 acatcttcca tcggctgggg cccc tgtctg tgttctcagc caagaaccgg tggcggctgg 2680 tggggcccgt ccacctgacc cgaggagagg gcggctttgg cctcacgctt cggggagact 2740 cgcctgtcct catcgctgcc gtcattccag ggagccaggc cgcggcggct ggcctgaagg 2800 agggcgacta cattgtgtca gtgaatgggc agccatgcag gtggtggaga cacgcggagg 2860 tggtgacgga gctgaaggct gcgggagagg cgggcgccag cctgcaggtg gtgtcgctgc 2920 tgcccagctc tagactgccc agcttggggg accgccggcc cgtcctgctg ggccccaggg 2980 ggcttctaag gagccagagg gagcatggtt gcaagacccc ggcatccacg tgggccagtc 3040 cccggcccct cctcaactgg agccgaaagg cccagcaggg caagactgga ggctgccccc 3100 agccctgtgc cccagtgaag ccagctccgc cctcatcctt gaagcaccca gggtggccgt 3160 gagggccagg atccctgcac gcctcagccc tggctccagc tggcagcaag caccgagcat 3220 gccctcccca cccagaggac ctccgggcaa tgcctgtccc gcctcatgct ggaggctgcc 3280 tcgggcacct gcctgcccat taaagactgg tcagacctgt ctgagcccag tgatgggagc 3340 tgtggcctct tcacccacac acagaaggat gccagtccct ctgtcggtct gaggtcagct 3400 tcctggggct gccccaccct gagggctcct tacagggtgc tcctcacagc catcccatct 3460 gtacccccgg gctctgtcca ccctgctgc t gccctgggca cagaccctga ggtctcagtc 3520 ctgcctccag ccaagtttct gcctggtgcc cagtgattcc tgctgggcac cccttcgctc 3580 actgcccctc caccatgcag cagccagaca cacccacagc acccgcagac ctctaggccg 3640 ggtcccagac atggccttcc cccaaaatac ttcctgctgt cctgtctgtg cacagagcaa 3700 gggactcccc acctctgcgc cctgtcctgg tcatcatggg ctctgtgctg gtcaacccag 3760 caagtgtccc gtttgcccag gagtccctgg tgtcgtggcc caggtctcat ggtggcccta 3820 agcctgccag ccctgctgcc cgccttgctg tcctgctctg agcatgggtg ccaccctcca 3880 gctcctgggc gtgtcacttc tctctgagcc tggggcctgc atgggccccc agccctcccc 3940 agcctgcttg ggccactcct gctggcctcc acaggccgtg agctgtcagt gtctcaagca 4000 ggggaagtga gggctgcctc caggcctccg tgtactgggt ggacaatggc ccccaaaggc 4060 cgtcggcaag aacaccacct ccaggacccc tacagcagtg ggctcaggac ttgggcacca 4120 agaggagagg gtgggaaggg ctgcagagtc agggctgcac ccaagaggag ccacggagcc 4180 ggagccggag cggaggcccc caccgagggc cccagggcct ggcaggttcc ggaagagaca 4240 gggccagcgg gagtcattcc ctgcagccac tagggggcag ccgccacccg ctcagcagcc 4300 ctgggaggcg gcacgggcag gtgcgccttg ggag ggctga ggcaaagacc ccgggtagaa 4360 aggcggcccc cagctctgcg agacccctgc cctcttgtcc agtcccttcc gagggtccgc 4420 aggtgagagc agcctgccct gcatcccagg ctctggttcc agggtccagg gccctgcgct 4480 gccacctccc tcgtgcttca gccaagaaaa tgggggtgca agtagggtgt ttggggtccc 4540 agagacgcag gcgccgcggc gcgatcttcc tgggcaggag ggcagggctc cccaacctgc 4600 ctgagccggg gtgggggtcc aggtccccca cttgcccttg tgggaaaatc cctgtctcag 4660 cagaatgggc caaggtcatg caggtctccc cagcacgtgt taatttggtt aataaaactg 4720 tggatcaag 4729 <210> 114 <211> 3725 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2219) <400> 114 cg cac ctg gac gac gcc cgg cgc cag cac atc gca gaa aaa acc ggg 47 His Leu Asp Asp Ala Arg Arg Gln His Ile Ala Glu Lys Thr Gly 1 5 10 15 aag atc ctg acg gag ttc ctc cag ttc tat gaa gac cag tat ggc gtg 95 Lys Ile Leu Thr Glu Phe Leu Gln Phe Tyr Glu Asp Gln Tyr Gly Val 20 25 30 gct ctc ttc aac agc atg cgc cat gag att gag ggc acg ggg ctg ccg 143 Ala Leu Phe Asn His Glu Ile Glu Gly Thr Gly Leu Pro 35 40 45 cag gcc cag ctg ctc tgg cgc aag gtg cca ctg gac gag cgc atc gtc 191 Gln Ala Gln Leu Leu Trp Arg Lys Val Pro Leu Asp Glu Arg Ile Val 50 55 60 ttc tc ggg aac ctc ttc cag cac cag gag gac agc aag aag tgg aga 239 Phe Ser Gly Asn Leu Phe Gln His Gln Glu Asp Ser Lys Lys Trp Arg 65 70 75 aac cgc ttc agc ctc gtg ccc cac aac tac ggg ctg gct 287 Asn Arg Phe Ser Leu Val Pro His Asn Tyr Gly Leu Val Leu Tyr Glu 80 85 90 95 aac aaa gcg gcc tat gag cgg cag gtc cca cca cga gcc gtc atc aac 335 Asn Lys Ala Ala Tyr Glu Arg Gln Val Pro Pro Arg Ala Val Ile Asn 100 105 110 agt gca ggc tac aaa atc ctc acg tcc gtg gac caa tac ctg gag ctc 383 Ser Ala Gly Tyr Lys Ile Leu Thr Ser Val Asp Gln Tyr Leu Glu Leu 115 120 125 att ggc aac tcc tta cca ggg acc acg gca aag tcg ggc agt ccc 431 Ile Gly Asn Ser Leu Pro Gly Thr Thr Ala Lys Ser Gly Ser Ala Pro 130 135 140 atc ctc aag tgc ccc aca cag ttc ccg ctc atc ctc tgg cat cct tat 479 Ile Leu Lys Cys Pro Thr Gln Phe Pro Leu Ile Leu Trp His Pro Tyr 145 150 155 gcg cgt cac tac tac ttc tgc atg atg aca gaa gcc gag cag gac aag 527 Ala Arg His Tyr Tyr Phe Cys Met Met Thr Glu Ala Glu Gln Asp Lys 160 165 170 175 tgg cag gct gtg ctg cag gac tgc atc cgg cac tgc aac aat gga atc 575 Trp Gln Ala Val Leu Gln Asp Cys Ile Arg His Cys Asn Asn Gly Ile 180 185 190 cct gag gac tcc aag gta gag ggc cct gcg ttc aca gat gcc atc cgc 623 Pro Ser Lys Val Glu Gly Pro Ala Phe Thr Asp Ala Ile Arg 195 200 205 atg tac cga cag tcc aag gag ctg tac ggc acc tgg gag atg ctg tgt 671 Met Tyr Arg Gln Ser Lys Glu Leu Tyr Gly Thr Trp Glu Met Leu Cys 210 215 220 ggg aac gag gtg cag atc ctg agc aac ctg gtg atg gag gag ctg ggc 719 Gly Asn Glu Val Gln Ile Leu Ser Asn Leu Val Met Glu Glu Leu Gly 225 230 235 cct gag ctg aag gca gag ccc ggc ggc ggc ggc ggc ggc ggc ggg aaa ccg cag 767 Pro Glu Leu Lys Ala Glu Leu Gly Pro Arg Leu Lys Gly Lys Pro Gln 240 245 250 255 gag cgg cag cgg cag tgg atc cag atc tcg gac gcc gtg tac cac atg 815 Glu Arg Gln Arg Gln Trp Ile Gln Ile Ser Asp Ala Val Tyr His Met 260 265 270 gtg tac gag cag gcc aag gcg cgc ttc gag gag gtg ctg tcc aag gtg 863 Val Tyr Glu Gln Ala Lys Ala Arg Phe Glu Glu Val Leu Ser Lys Val 275 280 gt cag cag cag ccg gcc atg cag gcc gtc atc cga act gac atg gac 911 Gln Gln Val Gln Pro Ala Met Gln Ala Val Ile Arg Thr Asp Met Asp 290 295 300 caa att atc acc tcc aag gag cac ctt gcc agc aag atc cga gcc ttc 959 Gln Ile Ile Thr Ser Lys Glu His Leu Ala Ser Lys Ile Arg Ala Phe 305 310 315 atc ctc ccc aag gca gag gtg tgc gtg cgg aac cat gtc cag ccc tac 1007 Ile Leu Pro Lys Ala Glu Val Cys Val Arg Asn His Val Gl n Pro Tyr 320 325 330 335 atc cca tcc atc ctg gag gcc ctg atg gtc ccc acc agc cag ggc ttc 1055 Ile Pro Ser Ile Leu Glu Ala Leu Met Val Pro Thr Ser Gln Gly Phe 340 345 350 act gag gtg cga gat gtc ttc ttc aag gag gtc acg gac atg aac ctg 1103 Thr Glu Val Arg Asp Val Phe Phe Lys Glu Val Thr Asp Met Asn Leu 355 360 365 aac gtc atc aac gag ggc ggc att gac aag ctg ggc gag tac atg gag 1151 Asn Ile Val Glu Gly Gly Ile Asp Lys Leu Gly Glu Tyr Met Glu 370 375 380 aag ctg tcc cgg ctg gcg tac cac ccc ctg aag atg cag agcgg tgc tat 1199 Lys Leu Ser Arg Leu Ala Tyr His Pro Leu Lys Met Gln Ser Cysyr 395 gag aag atg gag tcg ctg cga ctg gac ggg ctg cag cag cga ttt gat 1247 Glu Lys Met Glu Ser Leu Arg Leu Asp Gly Leu Gln Gln Arg Phe Asp 400 405 410 415 gtg tcc agc acg tcc gtg ccc gag cag atc cac atg cgg 1295 Val Ser Ser Thr Ser Val Phe Lys Gln Arg Ala Gln Ile His Met Arg 420 425 430 gag caa atg gac aat gcc gtg tat acg ttc gag acc ctc ctg cac cag 1343 Glu Gln Met Asp Asn Ala Val Ty r Thr Phe Glu Thr Leu Leu His Gln 435 440 445 gag ctg ggg aag ggg ccc acc aag gag gag ctg tgc aag tcc atc cag 1391 Glu Leu Gly Lys Gly Pro Thr Lys Glu Glu Leu Cys Lys Ser Ile Gln 450 455 460 cgg gtc ctg gag cgg gtg ctg aag aaa tac gac tac gac agc agc tct 1439 Arg Val Leu Glu Arg Val Leu Lys Lys Tyr Asp Tyr Asp Ser Ser Ser 465 470 475 gtg cgg aag agg ttc ttc cgg gag gcg ctg ccg cag atg 1487 Val Arg Lys Arg Phe Phe Arg Glu Ala Leu Leu Gln Ile Ser Ile Pro 480 485 490 495 ttc ctg ctc aag aag ctg gcc cct acc tgc aag tcg gag ctg ccc cgg 1535 Phe Leu Leu Lys Lys Leu Ala Pro Thr Cys Glu Leu Pro Arg 500 505 510 ttc cag gag ctg atc ttc gag gac ttt gcc agg ttc atc ctg gtg gaa 1583 Phe Gln Glu Leu Ile Phe Glu Asp Phe Ala Arg Phe Ile Leu Val Glu 515 520 525 aac acg gag gag gag ctg cag acc gtc atg aag gac atc ctg 1631 Asn Thr Tyr Glu Glu Val Val Leu Gln Thr Val Met Lys Asp Ile Leu 530 535 540 cag gct gtg aag gag gcc gcg gtg cag agg aag cac aac ctc tac cgg 1679 Gln Ala al Lys Glu Ala Ala Val Gln Arg Lys His Asn Leu Tyr Arg 545 550 555 gac agc atg gtc atg cac aac agc gac ccc aac ctg cac ctg ctg gcc 1727 Asp Ser Met Val Met His Asn Ser Asp Pro Asn Leu His Leu Leu Ala 560 565 570 575 gag ggc gcc ccc atc gac tgg ggc gag gag tac agc aac agc ggc ggg 1775 Glu Gly Ala Pro Ile Asp Trp Gly Glu Glu Tyr Ser Asn Ser Gly Gly 580 585 590 ggc ggc agc ccc agc ccc agc ccc agc ccc agc ccc agc ccc agc ccc agc tca gcc acc ctc tcg gaa 1823 Gly Gly Ser Pro Ser Pro Ser Thr Pro Glu Ser Ala Thr Leu Ser Glu 595 600 605 aag cga cgg cgc gcc aag cag gtg gtc tct gtg gtc cag gat gag gag 1871 Lys Arg Arg Arg Ala Lys Gln Val Val Ser Val Val Gln Asp Glu Glu 610 615 620 gtg ggg ctg ccc ttt gag gct agc cct gag tca cca cca cct gcg tcc 1919 Val Gly Leu Pro Phe Glu Ala Ser Pro Glu Ser Pro Pro Pro Ala Ser 625 630 635 635 ccg gac ggt gtc act gag atc cga ggc ctg ctg gcc caa ggt ctg cgg 1967 Pro Asp Gly Val Thr Glu Ile Arg Gly Leu Leu Ala Gln Gly Leu Arg 640 645 650 650 655 cct gag agc ccc cca cca gcc ggc ccc ccg gc ag ccc gct 2015 Pro Glu Ser Pro Pro Pro Ala Gly Pro Leu Leu Asn Gly Ala Pro Ala 660 665 670 ggg gag agt ccc cag cct aag gcc gcc ccc gag gcc tcc tcg ccg cct 2063 Gly Glu Ser Pro Gln Pro Lys Ala Ala Pro Glu Ala Ser Ser Pro Pro 675 680 685 gcc tca ccc ctc cag cat ctc ctg cct gga aag gct gtg gac ctt ggg 2111 Ala Ser Pro Leu Gln His Leu Leu Pro Gly Lys Ala Val Asp Leu Gly 690 695 700 ccc ccc aag ccc agc gac cag gag act gga gag cag gtg tcc agc ccc 2159 Pro Pro Lys Pro Ser Asp Gln Glu Thr Gly Glu Gln Val Ser Ser Pro 705 710 715 agc agc cac ccc gcc ctc cac acc acc acc gag gac agt gca ggg gtg 2207 Ser Ser His Pro Ala Leu His Thr Thr Thr Glu Asp Ser Ala Gly Val 720 725 730 735 cag act gag ttc taggccagtg ggtccctgac tgctgcacat ggcacaggcc 2259 Gln Thr Glu Phe gttcccttcc ggacccaggc aggctcagct ctggggaggg caccctggtc tgtgccttgt 2319 gggtggaggc ggggcagggc tgtgtggcac cgccagggag cgggcccacc tgagtcactt 2379 tattgggttc agtcaacact ttcttgctcc ctgttttctc ttctgtggga tgatctcaga 2439 tgcaggggct ggttttgggg ttttcctgct tgtgccaagg gctggacact gctggggggc 2499 tggaaagccc ctcccttcct gtccttctgt ggcctccatc ccctcatggg tgctgccatc 2559 cttcctggag agagggaggt gaaagctggt gtgagcccag tgggttcccg cccactcacc 2619 caggagctgg ctgggccagg accgggagag ggagcactgc tgccctcctg gccctgctcc 2679 ttccgcagtt aggggtggac cgagcctcgc tttccccact gttctggagg gaaggggaag 2739 gagggggtct tcaggctgga gccaggctgg gggtgctggg tggagagatg agatttaggg 2799 ggtgcctcat ggggtgggca ggcctggggt gaaatgagaa aggcccagaa cgtgcaggtc 2859 tgcggagggg aagtgtcctg agtgaaggag gggaccccca tcctggggga tgctgggagt 2919 gagtgagtga gtgagatggc tgagtgaggg ttatggggag cctgaggttt tatgggcctg 2979 tgtatcccct tctcccggcc ccagcctgcc tccctcctgc ccgcctggcc cacaggtctc 3039 cctctggtcc ctgtccctct ggtggttggg gatggagcgg cagcaagggg tgtaatgggg 3099 ctgggttctg tcttctacag gccaccccga ggtcctcagt ggttgcctgg ggagccggac 3159 ggggctcctg aggggtacag gttgggtggg ccctccctga gggtctgggg tcaggctttg 3219 gcctctgctg cctctcagtc accaagtcac ctccctctga aaatccagtc ccttctttgg 3279 atgtccttgt gagtcactct gggcctggct gtcgt ccctc ctcagcttct tgttcctggg 3339 acaagggtca agccaggatg ggcccaggcc tgggatcccc caccccagga cccccaggcc 3399 ccctcccctg ctgctttgcg gggggcaggg cagaaatgga ctccttttgg gtccccgagg 3459 tggggtcccc tcccagccct gcatcctccg tgccgtagac ctgctcccca gaggaggggc 3519 cttgacccac aggacgtgtg gtggcgcctg gcactcaggg acccccagct gccccagccc 3579 tggtctctgg cgcatctctt ccctcttgtc ccgaagatct gcgcctctag tgccttttga 3639 ggggttccca tcatccctcc ctgatattgt attgaaaata ttatgcacac tgttcatgct 3699 tctactaatc aataaacgct ttattt 3725 <210> 115 <211> 3566 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1739) <400> 115 gc agc atg aag gaa gag ccg ctg ggc agc ggc atg aac gcg gtg cgg 47 Ser Met Lys Glu Glu Pro Leu Gly Ser Gly Met Asn Ala Val Arg 1 5 10 15 acg tgg atg cag ggc gcc ggg gtg ctg gcc aac acg gcg gcg cag 95 Thr Trp Met Gln Gly Ala Gly Val Leu Asp Ala Asn Thr Ala Ala Gln 20 25 30 agc ggg gtg ggt ctg gcc cgg gct cac ttt gag aag cag ccg cct tcc 143 Ser Gly Val Gly Leu Ala Arg Ala His Phe Glu Lys Gln Pro Ser 35 40 45 aat ctg cgg aaa tcc aac ttc ttc cac ttc gtc ctg gcc ctc tac gac 191 Asn Leu Arg Lys Ser Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp 50 55 60 aga cag ggc cag ccc gtg gag atc gag agg aca gcg ttt gtg ggg ttc 239 Arg Gln Gly Gln Pro Val Glu Ile Glu Arg Thr Ala Phe Val Gly Phe 65 70 75 gtg gag aag gaa aaa gaa gcc aac agc gaa ag acc atat 287 Val Glu Lys Glu Lys Glu Ala Asn Ser Glu Lys Thr Asn Asn Gly Ile 80 85 90 95 cac tac cgg ctt cag ctt ctc tac agc aat ggg ata agg acg gag cag 335 His Tyr Arg Leu Gln Leu Leu Tyr Ser Asn Gly Ile Arg Thr Glu Gln 100 105 110 gat ttc tac gtg cgc ctc att gac tcc atg aca aaa caa gcc ata gtg 383 Asp Phe Tyr Val Arg Leu Ile Asp Ser Met Thr Lys Gln Ala Ile Val 115 120 125 tat gaa ggc caa gac aag aac cca gaa atg tgc cgt aca 431 Tyr Glu Gly Gln Asp Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr 130 135 140 cat gag atc atg tgc agc cgc tgt tgt gac aag aaa agc tgt ggc aac 479 His Glu Ile Met Cys Ser Arg Cys Cys Asp Lys Lys Ser Cys Gly Asn 145 150 155 cga aat gag act ccc tca gat cca gtg ata att gac agg ttc ttc ttg 527 Arg Asn Glu Thr Pro Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu 160 165 170 175 aaa ttt ttc ctc aaa tgt aac caa aat tgc cta aag aat gcg gga aac 575 Lys Phe Phe Leu Lys Cys Asn Gln Asn Cys Leu Lys Asn Ala Gly Asn 180 185 190 cca cgt gac atg cgg aga ttc cag gtc gtg gtg tct acg aca gtc asp 623 Met Arg Arg Phe Gln Val Val Val Ser Thr Thr Val Asn 195 200 205 gtg gat ggc cat gtc ctg gca gtc tct gat aac atg ttt gtc cat aat 671 Val Asp Gly His Val Leu Ala Val Ser Asp Asn Met Phe Val His Asn 21 0 215 220 aat tcc aag cat ggg cgg agg gct cgg agg ctt gac ccc tcg gaa ggt 719 Asn Ser Lys His Gly Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Gly 225 230 235 acg ccc tct tat ctg gaa cat gca gct act ccc tgt atc aaa gcc atc 767 Thr Pro Ser Tyr Leu Glu His Ala Ala Thr Pro Cys Ile Lys Ala Ile 240 245 250 255 agc ccg agt gaa gga tgg acg acg gga ggt gcg act gtg atc atc ata ata 815 Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly Ala Thr Val Ile Ile Ile 260 265 270 ggg gac aat ttc ttt gat ggg tta cag gtc ata ttc ggt acc atg ctg 863 Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Ile Phe Gly Thr Met Leu 275 280 285 gtc t agt gag ttg atc act cct cat gcc atc cgt gtg cag acc cct 911 Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg Val Gln Thr Pro 290 295 300 cct cgg cac atc cct ggt gtt gtg gaa gtc aca ctg tcc tac aaa tct 959 Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu Ser Tyr Lys Ser 305 310 315 aag cag ttc tgc aaa gga aca cca ggc aga ttc att tat aca gcg ctc 1007 Lys Gln Phe Cys Lys Gly Thr Pro Gly Arg Phe Ile TyrThr Ala Leu 320 325 330 335 aac gaa ccc acc atc gat tat ggt ttc cag agg tta cag aag gtc att 1055 Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu Gln Lys Val Ile 340 345 350 cct cgg cac cct ggt gac cct gag cgt ttg cca aag gaa gta ata ctc 1103 Pro Arg His Pro Gly Asp Pro Glu Arg Leu Pro Lys Glu Val Ile Leu 355 360 365 aaa agg gct gcg gat ctg gta gaa gca ctg tat ggg atg cca cac aac 1151 Lys Arg Ala Ala Asp Leu Val Glu Ala Leu Tyr Gly Met Pro His Asn 370 375 380 aac cag gaa atc att ctg aag aga gcg gcc gac att gcc gag gcc ctg 1199 Asn Gln Glu Ile Ile Leu Lys Arg Ala Ala Asp Ile Ala Glu Ala Leu 395 tac agt gtt ccc cgc aac cac aac caa ctc ccg gcc ctt gct aac acc 1247 Tyr Ser Val Pro Arg Asn His Asn Gln Leu Pro Ala Leu Ala Asn Thr 400 405 410 415 tcg gtc cac gca ggg atg atg ggc gtg aat tg agt gga caa ctg 1295 Ser Val His Ala Gly Met Met Gly Val Asn Ser Phe Ser Gly Gln Leu 420 425 430 gcc gtg aat gtc tcc gag gca tca caa gcc acc aat cag ggt ttc acc 1343 Ala Val Asn Val Ser Glu Ala Ser Gln Ala Thr Asn Gln Gly Phe Thr 435 440 445 cgc aac tca agc agc gta tca cca cac ggg tac gtg ccg agc acc act 1391 Arg Asn Ser Ser Ser Val Ser Pro His Gly Tyr Val Pro Ser Thr Thr 450 455 460 ccc cag cag acc aac tat aac tcc gtc acc acg agc atg aac gga tac 1439 Pro Gln Gln Thr Asn Tyr Asn Ser Val Thr Thr Ser Met Asn Gly Tyr 465 470 475 ggc tct gcc gca atg tcc aat ttg ggc ggc tcc ccc acc ttc ctc ac 1487 Gly Ser Ala Ala Met Ser Asn Leu Gly Gly Ser Pro Thr Phe Leu Asn 480 485 490 495 ggc tca gct gcc aac tcc ccc tat gcc ata gtg cca tcc agc ccc acc 1535 Gly Ser Ala Ala Asn Ser Pro Tyr Ala Ile Val Pro Ser Ser Pro Thr 500 505 510 atg gcc tcc tcc aca agc ctc ccc tcc aac tgc agc agc tcc tcg ggc 1583 Met Ala Ser Ser Thr Ser Leu Pro Ser Asn Cys Ser Ser Ser Ser Ser Gly 515 520 525 atc ttc tcc ttc tca cca gcc aac atg gtc tca gcc gtg aaa cag aag 1631 Ile Phe Ser Phe Ser Pro Ala Asn Met Val Ser Ala Val Lys Gln Lys 530 535 540 agt gct ttc gca cca gtc gtc aga ccc cag acc tcc cca cct ccc acc 1679 Ser Ala Phe Ala Pro Val Val Arg Pro Gln Thr Ser Pro Pro Pro Thr 545 550 555 tgc acc agc acc aac ggg aac agc ctg caa gcg ata tct ggc atg att 1727 Cys Thr Ser Thr Asn Gly Asn Ser Leu Gln Ala Ile Ser Gly Met Ile 560 565 570 575 gtt cct cct atg tgaaagaatt gccttgaaga attgtattaa tgaagaggtt 1779 Val Pro Pro Met ggattctgct acagagagta atctgataca agtcccagag tggaactttt aactcaggcc 1839 tttttaagag gaatcacaat aactgcagat ttttaaacaa acaaaatcac cgaccttgca 1899 aatactgaaa ttggaagagg gatctgcaag tgcagggtgt tggttaaagt tgtacctccc 1959 aagtatttgg gggatatatt tattctgtat tgacaaaagc aaatccactt tttctttttc 2019 tttttttttt ttaagcttaa ttctgcaatc atttgtcttt tataaaccgt aaagctctat 2079 acaagggaca ctataaataa gactccatgt tttaatttat gatgttttta aagctgtgta 2139 aaggaagaat gaagtggtga tatttacaaa aaagtaaaaa aaaaaaaaaa gaaaaaaagt 2199 aaaaaaaaaa agcttgtatg ggacagaata ggaatgccag ttagattttt tagaaaaact 2259 aagggtcggc ttttgcgcct taaagcatat caaatggtag ttagctcaga cagtgcattt 2319 tcaatatcta acttaacatg ccacccctta gcagtgcaag cttatttatc tcttttgt at 2379 tgttgtctta agcaactgtg taaataaatg cagcctggaa agttaaaacg cgatgtaagt 2439 gatcacattt ttccctctac tcgaaaatcc agtgcctcta gacagattgt taaaactgca 2499 tatttaaatc tgatctcatt ctctcctttt acttaagtca gtttcttctg aagccgatgg 2559 cctctcgaga gcttggtggc acacatactg tgtgagaatc tcctttgaga cttcatggaa 2619 cagggtccag gcacagaatt ccacactctg ccctccagtt aacaagccaa aacctcacgt 2679 acgctccccc atttgcaagt ttaaagttta ctcgtcctaa atgcagactt catacctatc 2739 ttccaaaagt tgataaaagc aacgtggcag gtattttcga ttttcccatt ccagatactg 2799 cctctatcag tcgaccctta ccatttgtaa cataatagat tgaaacaaca ggttaagtgc 2859 tttggaatta agagttaaag ggaaccgggg gtggagaaag gaaaagaagg ttgagacctc 2919 caaaacatag ttttctgttc tatgggaatt tttgctctca ttatctggga agtgttctta 2979 aaaataagaa ttaatagcaa agatgcagca aagctctgag gatgcatttg cctgatattt 3039 ttttctttgc tcttgtgttt ttgtatgtag ttataaatac tgtagatttt ttttttgtga 3099 ttttttgcca aagttgttgt tctatttata cattttaatg tcttaagaca ttttttcaat 3159 atcacaaaaa gattttactg cgtattttgc aaagaaaaaa agctcactac ctttagcttg 32 19 cacatacttg caaagttaat taaaaggctt tttgttttaa aggggatttt gtaaaatatc 3279 catataaata atgtatttat ctttcgaatt tgtacattgc ttttcccttc ttcctcttcc 3339 ttccaccccc aatttatttt attgtgtatg tttgctacgt gaaaagtgcg tatttgtttg 3399 gtcacctaca cttgtattag ctgtttcaat gtgattttta aacatttcat ttatagttat 3459 ttttagtatt gttataaacc atgcttcagt ttttttaatt tccacccaaa agtcattgtc 3519 tatttttgta ttatttgtaa gttaagaagt tttttccaat atatggc 3566 <210> 116 <211> 4296 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1755) .. (3731) <400> 116 cccagatagt cacatttaaa ggttgctagt ttgaaatttg caaatgcttc cctgctgtca 60 gagttaggtt tcctacagct gtaagatagc tgctactcaa cctacagcag atgcccgtga 120 cattgtgtgt tcctgggtgt atctcccatc tagcaactcc aaactgtgta tgctgtagtt 180 tgtgttcctg gaactactat cttcaggaga agcttcagtt ataaatagta attggagtga 240 agagatgagt tctgtttagg ggagatccat taactttcaa caagggagga cagggacttt 300 ttcaatagga attgcaataa catggtttgt ttttgaaaat gcaatagact gtggattaaa 360 tagctattgc acacaaagaa gaaaataaag ttataatctc cagcatgaga tctggattta 420 catatgctct gttagctgca agaatttggg caagctattt aatttccata aatttaggta 480 tccttaagat acccactgct tagagttatt gtgagaatta attgaggtaa gaaaactgag 540 gctcaggttg tcatttgctc aaatcacaca gcaaaaccgt gatagaatgc agattcaaac 600 tgggatatta acattccaaa gcctttacag ttattgacta ctattcagca ctgccttcaa 660 tatatgctga tgactgcaca caggagttag aaatgcccac tgtcacttgc ctgccttgag 720 cggtttcttg tttgtataaa taatccaaaa tacttggttg tgttgtaaga agcaccgtgt 780 tttgtgagac atttcaaagg taccacaaat aggaaagatt tcattctaga atgaatagag 840 cacatattta gtatctacgt gctgtttggt taattttagt tatttggtca tgcttttaaa 900 atctattttt atagtatata ttttctttta tagcatatca gaattatctt tagattcaac 960 tcttcatgcc gtcaatcttc attgcaataa catctccaag atcgaagcca ttgatcatat 1020 ttggaattta caacatctag atctgtcatc taatcaaata agtagaattg aaggactaaa 1080 cacactgaca aaactgtaca cattaaattt gtcctgcaat ttgattacaa aagtagaagg 1140 acttgaagaa ctaattaatc tgactagact aaatgtatct tataaccaca tagatgatct 1200 tagtggattg attccccttc atggaattaa gcataaactt agatatattg atctacatag 1260 taatcgtata gatagtatcc atcacttact tcagtgtatg gtaggattgc acttcctgac 1320 caatcttatt ttggagaaag atggagacga taatcctgtc tgtcgactgc cagggtacag 1380 agcagttatt ctccagactt tgccacagct tagaatccta gattgcaaga acatatttgg 1440 tgaaccagta aatttgacag aaataaattc atcacagctg cagtgcctag aaggtctttt 1500 ggataattta gtttcttctg attctcccct aaatataagt gaagatgaga tcattgatag 1560 aatgccagtg ataacagcac ctatcgatga gttagttccc ttggaacagt ttgcaagtac 1620 accaagtgat gctgtgttga cgtcttttat gtctgtgtgt caatcttctg agccagagaa 1680 aaataatcat gaaaacg att tgcagaatga gataaaactt cagaaattag atgaccaaat 1740 tctacaactt ctaa atg aat tgt aat cgt aaa atg aaa cca cct tac ctt 1790 Met Asn Cys Asn Arg Lys Met Lys Pro Pro Tyr Leu 1 5 10 aaa gaa tta tca t g c tta tca t g c ag c tta tca t g c ag c tta caa 1838 Lys Glu Leu Tyr Val Ser Ser Ser Leu Ala Asn Cys Pro Met Leu Gln 15 20 25 gaa tca gaa aag cca aag act gaa ata att aaa gta gac caa agt cac 1886 Glu Ser Glu Lys Pro Lys Thr Glu Ile Ile Lys Val Asp Gln Ser His 30 35 40 tca gaa gac aac act tac cag tcc ctt gtt gaa cag cta gac caa gag 1934 Ser Glu Asp Asn Thr Tyr Gln Ser Leu Val Glu Gln Leu Asp Gln Glu 45 50 55 60 aga gag aag aga tgg aga gct gag caa gcc gaa aat aaa ctc atg gat 1982 Arg Glu Lys Arg Trp Arg Ala Glu Gln Ala Glu Asn Lys Leu Met Asp 65 70 75 tat att gat gag ctg cat aaa cat gca aat gaa aaa gag gat att cat 2030 Tyr I Asp Glu Leu His Lys His Ala Asn Glu Lys Glu Asp Ile His 80 85 90 agt ctg gct cta ctt acc aca gat agg cta aag gaa att att ttt aga 2078 Ser Leu Ala Leu Leu Thr Thr Asp Arg Leu L ys Glu Ile Ile Phe Arg 95 100 105 gag aga aat tcc aaa gga caa ctc gaa gtt atg gtt cac aaa ctt caa 2126 Glu Arg Asn Ser Lys Gly Gln Leu Glu Val Met Val His Lys Leu Gln 110 115 120 aat gaa att aaa aaa ctg act gtt gaa cta atg aaa gca aaa gat caa 2174 Asn Glu Ile Lys Lys Leu Thr Val Glu Leu Met Lys Ala Lys Asp Gln 125 130 135 140 caa gag gat cac ctt aaa cac tta aga acc ctc gaa aaa aca tta gaa 2222 Gln Glu Asp His Leu Lys His Leu Arg Thr Leu Glu Lys Thr Leu Glu 145 150 155 aaa atg gag aga caa aaa agg cag cag cag gca gca cag ata aga ctg 2270 Lys Met Glu Arg Gln Lys Arg Gln Gln Gln Ala Ala Gln Ile Arg Leu 160 165 170 atc caa gag gtg gaa ctc aaa gct tca gct gcc gat aga gaa ata tac 2318 Ile Gln Glu Val Glu Leu Lys Ala Ser Ala Ala Ala Asp Arg Glu Ile Tyr 175 180 185 tta ctt aga act tcc ctt cat cga gaa gaa caa gcg caa caa ctt 2366 Leu Leu Arg Thr Ser Leu His Arg Glu Arg Glu Gln Ala Gln Gln Leu 190 195 200 cat caa ctt ctt gca ttg aaa gaa cag gaa cac agg aag gaa ctt gaa 2414 His Gln Leu Leu Ala Leu Lys Glu Gln Glu His Arg Lys Glu Leu Glu 205 210 215 220 aca agg gag ttt ttt act gat gct gac ttc cag gat gcc tta gct aaa 2462 Thr Arg Glu Phe Phe Thr Asp Ala Asp Phe Gln Asp Ala Leu Ala Lys 225 230 235 gaa ata gcc aaa gaa gag aaa aag cat gag caa atg ata aaa gaa tac 2510 Glu Ile Ala Lys Glu Glu Lys Lys His Glu Gln Met Ile Lys Glu Tyr 240 245 250 caa gag aaa att gac gtg tta agc cag cag tat atg gaa aat 2558 Gln Glu Lys Ile Asp Val Leu Ser Gln Gln Tyr Met Asp Leu Glu Asn 255 260 265 gaa ttc cgt att gct tta act gtt gaa gcc aga aga ttt caa gat gtt 2606 Glu Phe Arg Ile Ala Leu Thr Val Glu Ala Arg Arg Phe Gln Asp Val 270 275 280 aaa gat ggt ttt gaa aat gtt gca act gag tta gca aag agc aaa cat 2654 Lys Asp Gly Phe Glu Asn Val Ala Thr Glu Leu Ala Lys Ser Lys His 285 290 295 295 300 gct ctt att tgg gct caa cga aaa gaa aat gag tct tcc tct tta att 2702 Ala Leu Ile Trp Ala Gln Arg Lys Glu Asn Glu Ser Ser Ser Leu Ile 305 310 315 aaa gat ctg acc tgt atg gta aag gaa caa aaa aca aaa ctg gca gaa 2750 Lys Asp Leu Thr Cys Met Val Lys Glu Gln Lys Thr Lys Leu Ala Glu 320 325 330 gtt tct aaa ttg aaa caa gaa aca gca gca aat tta cag aat caa atc 2798 Val Ser Lys Leu Lys Gln Glu Thr Ala Ala Asn Leu Gln Asn Gln Ile 335 340 345 aac acc ctt gaa att tta att gaa gat gac aag cag aag agt att caa 2846 Asn Thr Leu Glu Ile Leu Ile Glu Asp Asp Lys Gln Lys Ser Ile Gln 350 355 360 ata gaa ctt ctc aag cac gaa aaa cag ctt att tct gag cta gca 2894 Ile Glu Leu Leu Lys His Glu Lys Val Gln Leu Ile Ser Glu Leu Ala 365 370 375 380 gcc aag gaa tca cta ata ttt ggt tta agg aca gaa aga aaa gta tgg 2942 Ala Lys Glu Ser Le Ile Phe Gly Leu Arg Thr Glu Arg Lys Val Trp 385 390 395 gga cat gag ctg gca caa caa gga tct tct cta gcc caa aat cgt gga 2990 Gly His Glu Leu Ala Gln Gln Gly Ser Ser Leu Ala Gln Asn Arg Gly 400 405 410 aaa ttg gag gct caa att gag agt tta tct aga gag aat gaa tgt ctg 3038 Lys Leu Glu Ala Gln Ile Glu Ser Leu Ser Arg Glu Asn Glu Cys Leu 415 420 425 cga aag aca aat gaa agt gat agt gat gca tta aga ta aag tgc aaa 3086 Arg Lys Thr Asn Glu Ser Asp Ser Asp Ala Leu Arg Ile Lys Cys Lys 430 435 440 atc ata gac gac caa act gaa act att aga aaa tta aaa gat tgt tta 3134 Ile Ile Asp Asp Gln Thr Glu Thr Ile Arg Lys Leu Lys Asp Cys Leu 445 450 455 460 caa gaa aaa gat gaa cac atc aaa aga tta caa gaa aag atc aca gaa 3182 Gln Glu Lys Asp Glu His Ile Lys Arg Leu Gln Glu Lys Ile Thr Glu 465 470 ga aaa ata tgc act caa gaa caa ctt gat gaa aaa tct tca caa ctg 3230 Ile Glu Lys Cys Thr Gln Glu Gln Leu Asp Glu Lys Ser Ser Gln Leu 480 485 490 gat gag gta ctt gag aag ttg gaa agg cac aat gaa aga aaa aaa 3 Asp Glu Val Leu Glu Lys Leu Glu Arg His Asn Glu Arg Lys Glu Lys 495 500 505 cta aaa caa cag ttg aaa gga aag gaa gta gaa ctt gaa gaa atc aga 3326 Leu Lys Gln Gln Leu Lys Gly Lys Glu Val Glu Leu Ile Arg 510 515 520 aaa gct tac agt aca ctg aat cgg aag tgg cat gat aaa gga gaa ctt 3374 Lys Ala Tyr Ser Thr Leu Asn Arg Lys Trp His Asp Lys Gly Glu Leu 525 530 535 540 cta tgt cat ctt gaa aca c aa gta aaa gaa gtg aaa gaa aaa ttt gaa 3422 Leu Cys His Leu Glu Thr Gln Val Lys Glu Val Lys Glu Lys Phe Glu 545 550 555 aac aag gaa aag aaa ctt aaa gcg gaa aga gac aaa agt att gaa cta 3470 Lys Lys Leu Lys Ala Glu Arg Asp Lys Ser Ile Glu Leu 560 565 570 caa aag aat gca atg gaa aaa ctt cat agt atg gat gat gcc ttt aaa 3518 Gln Lys Asn Ala Met Glu Lys Leu His Ser Met Asp Asp Ala Phe Lys 575 580 585 aga caa gtt gat gca att gtt gaa gct cat caa gct gaa ata gca cag 3566 Arg Gln Val Asp Ala Ile Val Glu Ala His Gln Ala Glu Ile Ala Gln 590 595 600 ctg gcc aat gaa aag cag aag tgt att gat tg aat tta aag gtc 3614 Leu Ala Asn Glu Lys Gln Lys Cys Ile Asp Ser Ala Asn Leu Lys Val 605 610 615 620 cat caa att gaa aaa gaa atg cgt gaa ctt ttg gaa gaa aca tgc aag 3662 His Gln Ilu Glug Lys Glu Leu Leu Glu Glu Thr Cys Lys 625 630 635 aac aaa aaa aca atg gaa gca aaa att aag cag ctt gct ttt gct tta 3710 Asn Lys Lys Thr Met Glu Ala Lys Ile Lys Gln Leu Ala Phe Ala Leu 640 645 650 aat g aa att cag caa gat atg tgatggttct gagaatgaat ttaattgaaa 3761 Asn Glu Ile Gln Gln Asp Met 655 tagaccagca gacctattgt aaaaatgatt aaatattgta atagtagtaa ctgctatgac 3821 tttgaaatgt ctctttctat acatttcatt atgaatatat ttttaaagac ttttgatcaa 3881 gtattaattg tataggtttt ttataataaa ttgttgacaa ttttgtctat tagaaaaaac 3941 tatcataact agacttacaa tatttttctt gtttctgtac tatacgttgt ttggtaatta 4001 cacatttgcc tacaaatttg tgaatgaaaa gattagtatt ttcaccatat gaggtaaaac 4061 attttaatca ttgttatctt attgtgatga tgaagaacta attatatttg ttatttaatt 4121 gatgtagctc aattctttta aagtacttat gtagccaaaa agcatttgaa atctgtatga 4181 taaaagatgt ggcatccatccat tgagcattacg tcatattag tcat 4g <210> 117 <211> 3794 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1478) <400> 117 gc cct gaa gcc agg caa gaa gtt ccc atg tat aca gac tct gaa ccc 47 Pro Glu Ala Arg Gln Glu Val Pro Met Tyr Thr Asp Ser Glu Pro 1 5 10 15 agg caa gaa gtt ccc atg tat aca gac tct gaa ccc agg caa gaa gtt 95 Arg Gln Glu Val Pro Met Tyr Thr Asp Ser Glu Pro Arg Gln Glu Val 20 25 30 ccc atg tat aca ggc tct gaa ccc agg caa gaa gtt ccc atg tat aca 143 Pro Met Tyr Thr Gly Ser Glu Pro Arg Gln Glu Val Pro Met Tyr Thr 35 40 45 ggc cct gaa tcc agg caa gaa gtt ccc atg tat aca ggc cct gaa tcc 191 Gly Pro Glu Ser Arg Gln Glu Val Pro Met Tyr Thr Gly Pro Glu Ser 50 55 60 agg caa gaa gtt tta ata cgg aca gac cct gaa tct agg caa gaa att 239 Arg Gln Glu Val Leu Ile Arg Thr Asp Pro Glu Ser Arg Gln Glu Ile 65 70 75 atg tgt aca ggc cat gaa tcc aaa cag gaa gtt ccc ata tgt acaat 287 Met Cys Thr Gly His Glu Ser Lys Gln Glu Val Pro Ile Cys Thr Asp 80 85 90 95 cct ata tcc aag caa gaa gac tcc atg tgt aca cac gct gaa atc aat 335 Pro Ile Ser Lys Gln Glu Asp Ser Met Cys Thr His Ala Glu Ile Asn 100 105 110 ca a aaa tta cct gta gca aca gat ttt gaa ttt aag cta gaa gct ctc 383 Gln Lys Leu Pro Val Ala Thr Asp Phe Glu Phe Lys Leu Glu Ala Leu 115 120 125 atg tgt aca aac cct gaa att aaa caa gaa gac ccc acaat gtg ggg 431 Met Cys Thr Asn Pro Glu Ile Lys Gln Glu Asp Pro Thr Asn Val Gly 130 135 140 cct gaa gta aag caa caa gta acc atg gtt tca gac act gaa atc tta 479 Pro Glu Val Lys Gln Gln Val Thr Met Val Ser Asp Thr Glu Ile Leu 145 150 155 aag gtt gct aga aca cat cac gtc caa gca gaa agc tac ctg gtg tac 527 Lys Val Ala Arg Thr His His Val Gln Ala Glu Ser Tyr Leu Val Tyr 160 165 170 175 aac atc atg agc agt gga gag att gaa tgc agc aac acc cta gaa gat 575 Asn Ile Met Ser Ser Gly Glu Ile Glu Cys Ser Asn Thr Leu Glu Asp 180 185 190 gag ctt gac cag gcc tta ccc agc cag gcc ttc att tac cgt ccc att 623 Glu Asp Gln Ala Leu Pro Ser Gln Ala Phe Ile Tyr Arg Pro Ile 195 200 205 cga cag cgg gtc tac tca ctc tta ctg gag gac tgt caa gat gtc acc 671 Arg Gln Arg Val Tyr Ser Leu Leu Leu Glu Asp Cys Gln Asp Val Thr Two 10 215 220 agc acc tgc cta gct gtc aag gag tgg ttt gtg tat cct ggg aac cca 719 Ser Thr Cys Leu Ala Val Lys Glu Trp Phe Val Tyr Pro Gly Asn Pro 225 230 235 ctg agg cac ccg gac ctc gtc agg gcc gct atg acc att cca ggg 767 Leu Arg His Pro Asp Leu Val Arg Pro Leu Gln Met Thr Ile Pro Gly 240 245 250 255 gga acg cct agt ttg aaa ata tta tgg ctg aac caa gag cca gaa ata 815 Gly Thr Pro Ser Leu Lys Ile Leu Trp Leu Asn Gln Glu Pro Glu Ile 260 265 270 cag gtt cgg cgc ttg gac aca ctc cta gcc tgt ttc aat ctt tcc tcc 863 Gln Val Arg Arg Leu Asp Throne Leu Leu Ala Cys Phe Asn Leu Ser Ser 275 280 285 tca gaa gag ctg cag gct gtc gaa agc cca ttt caa gct ttg tgc 911 Ser Arg Glu Glu Leu Gln Ala Val Glu Ser Pro Phe Gln Ala Leu Cys 290 295 300 tgc ctc ttg atc tac ctc ttt gtc gc gg gc gc gg 959 Cys Leu Leu Ile Tyr Leu Phe Val Gln Val Asp Thr Leu Cys Leu Glu 305 310 315 gat ttg cat gcg ttt att gcg cag gcc ttg tgc ctc caa gga aaa tcc 1007 Asp Leu His Ala Phe Ile Ala Gln Ala Leln Cy LeGly Lys Ser 320 325 330 335 acc tcg cag ctt gta aat cta cag cct gat tac atc aac ccc aga gcc 1055 Thr Ser Gln Leu Val Asn Leu Gln Pro Asp Tyr Ile Asn Pro Arg Ala 340 345 350 350 gtg cag ctg ggc tcc ctt ctc gtc cgc ggc ctc acc act ctg gtt tta 1103 Val Gln Leu Gly Ser Leu Leu Val Arg Gly Leu Thr Thr Leu Val Leu 355 360 365 gtc aac agc gca tgt ggc ttc ccc tgg aag acg agt gat ttc atg ccc 1151 Val Asn Ser Ala Cys Gly Phe Pro Trp Lys Thr Ser Asp Phe Met Pro 370 375 380 tgg aat gta ttt gac ggg aag ctt ttt cat cag aag tac ttg caa tct 1199 Trp Asn Val Phe Asp Gly Lys Leu Phe His Gln Lys Tyr Leu Gln Ser 385 390 395 gaa aag ggt tat gct gtg gag gtt ctt tta gaa caa aat aga tct cgg 1247 Glu Lys Gly Tyr Ala Val Glu Val Leu Leu Glu Gln Asn Arg Ser Arg 400 405 410 415 ctc acc aaa ttc cac aac ctg aag gcagtc aag gcc tgc atg 1295 Leu Thr Lys Phe His Asn Leu Lys Ala Val Val Cys Lys Ala Cys Met 420 425 430 aag gag aac aga cgc atc act ggc cga gcc cac tgg ggc tca cac cac 1343 Lys Glu Asn Arg Arg Ile Thr G ly Arg Ala His Trp Gly Ser His His 435 440 445 gca ggg agg tgg gga aga cag ggc tcc agc tac cac agg acg ggc tct 1391 Ala Gly Arg Trp Gly Arg Gln Gly Ser Ser Tyr His Arg Thr Gly Ser 450 455 460 ggg tat agc cgt tcc agt cag gga cag ccg tgg aga gac cag gga cca 1439 Gly Tyr Ser Arg Ser Ser Gln Gly Gln Pro Trp Arg Asp Gln Gly Pro 465 470 470 475 gga agc aga acag tat gag cat gac cag tgg aga agg tac tagtcaacct 1488 Ser Arg Gln Tyr Glu His Asp Gln Trp Arg Arg Tyr 480 485 490 ccagaaagag tatggagaga aaaagaggca cacctggacg cagagccctg ccagcgccct 1548 cctctgctgt tgcagctgca aggagaccat gcctgtggga gccaagcctc gcttgcatga 1608 agaaggaacg atgccttttt caatggtgtc tccctcccat tgtgcagaag agcttttgtt 1668 ggcttctctc ccgagcttgt gcctgattct gtggcccaaa acaatcattg ttaacatctt 1728 catgtgtttc attctgatct ttcattcata tatatgatgc ctagctaatt tcattttaaa 1788 ataaatggga atctgttgta ttctgatttt ttattagcaa cactagatta tgaggggtta 1848 tctcctgtta ttaaaaagtc agaaaacact atacagtagt cctcccttgt ctgcggggga 1908 gacatcccaa gaccctcagt ggatgcctga gactggatag tatggaatcc tacatatcta 1968 taccgtggct ttttcctcta cgtacatacc atgataaagc ttaacaaaga acagtgagag 2028 attaacagca accaataact aataaaagct atgtgaatgt ggtctctgtc aaaatatcgt 2088 gctgtaatca cccttcttgc tatctgaaaa ccaagaagac cactaagtga ctaatggtca 2148 gagaagctgg atgaggggct gattcatgtc ctgggcatga cagagcggga ggcacaaggt 2208 ttcatcacac tattcacaat ggcgagcaag ttaaaacgga tttcccattt aatttaattt 2268 tcagacttca gttgaccatg agtaaccgaa accacagaaa gtgaagctgg ggatatttca 2328 gaaattcttt tctaatcaga aattctaatc aaacataagt ttccaactat gtgttctctt 2388 ggtcctcaga agtgtttgaa tagaaaagta acaactaact tcccatcttt ctggtggaag 2448 agttaattct gcctggaggg ttctgcctgg gagacatgac agcatgtgtg tgactcctgt 2508 gtctgtttct gtggggtcat ccctttcgtt tcattttgcc agggcctggc tcaggatttt 2568 ttatggcagt gcctgtgaag acaagcctgg ccctccatcc agtcacacag gaaatccaca 2628 gagagcatgc tgagagcagc cagcggctgg gctgccatca ggcctggttt atgatgccac 2688 aagtgaatgg cacgtttgtt cctctttatc tctgagcatt gaaggacttt tggttaaaaa 2748 aaaaattaag ttcagagtaa tccttttcat ggaag aatct tcaggtcacc aaagaattga 2808 aattttaagc cccagattgt actgagctgt acctgtggga aaaggaatgg ccagggtatt 2868 gatgatggaa aagattcaaa tgaggagtta gaaggcaagc cctctgtggg cagccgtctt 2928 ccagaaacct cgaacttatg tctgtctcca cctgagaaag gagaagaaaa gctggtggtg 2988 acccctgctc ctgctgggcc atgccatggc tctgaagatg ccccgtgttc ttaggaggtg 3048 ctcacccctg gcacctaaag acatttcctt ctggttgttg ctctttaaaa acaaaataag 3108 cccctgaacg tgcttgcagg ccagtttgtg tgcctgcact tgacgaatta ccttgaccaa 3168 cgggccaaag gcacagagct ccaaggcatc atctttcctt aaaatcctga gtgtttatta 3228 aaaagggaca tggtctctag gtatcttatt acatttgtat ttcttacatt tgaaatatcc 3288 taaccgctcc cttcggtttc ttcttaagaa catttacatc taattatttt tcgtgcaagt 3348 cttgtaggac ccacatgttt tcctagcttt ggaaatcgat ttttttcatt cctcttatga 3408 ggatttccct atgtcagtaa acattaactt tctatttctt ccatttttgc tcatttgaaa 3468 cccctgctgc ttctagatct atttctttgc acttgtataa ctttgaaata aattcctcat 3528 cccttagact aagagagtgg gtgtctgtga aaattgtttt ctccttcata atacctaaat 3588 tctagtttgt cagtaaaata tttgtgtttg gttaacaagc tcttatttaa gccattgagt 3648 tagtataatc tttattacct ttgaaaaacc agagagctga attttttgtc attctaagtt 3708 gtaagtaaca ctgcagtcaa gtcttctgat gaaatttcca tatatcaaat tgaaaataaa 3768 gcaaaatata tttattactc ataact <210> 118 <211> 4525 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1594) <400> 118 g gag gcc aag agg aag ctg cgg atc ttg cag cgc gag ttg cag aac gtg 49 Glu Ala Lys Arg Lys Leu Arg Ile Leu Gln Arg Glu Leu Gln Asn Val 1 5 10 15 cag gtg aac cag aaa gtg ggc atg ttt gag gcg cac atc cag gca cag 97 Gln Val Asn Gln Lys Val Gly Met Phe Glu Ala His Ile Gln Ala Gln 20 25 30 agc tcc gcc att caa gcg ccc cgc agc ccg cgt ttg ggc agg gct cac 145 Ser Ser Ala Ile Ala Pro Arg Ser Pro Arg Leu Gly Arg Ala His 35 40 45 tcg ccc tcc ccg tgc ccc ttc cgc agc agc agt cag ccc cct gga agg 193 Ser Pro Ser Pro Cys Pro Phe Arg Ser Ser Ser Gln Pro Pro Gly Arg 50 55 60 gtc ctg gtt cag ggc gcc cgg agc gag gaa cgg agg aca aag tcc tgg 241 Val Leu Val Gln Gly Ala Arg Ser Glu Glu Arg Arg Thr Lys Ser Trp 65 70 75 80 ggg gag caa tgt cca gag act tca gga acc gac tcc ggg agg aaa gga 289 Gly Glu Gln Cys Pro Glu Thr Ser Gly Thr Asp Ser Gly Arg Lys Gly 85 90 95 ggg ccc agc cta tgc tcc tcg cag gtg aag aaa gga atg cca cct ctt 337 Gly Pro Ser Leu Cys Ser Ser Gln Val Lys Lys Gly Met Pro Pro Leu 100 105 110 ccc ggc cgg gct gcc cct aca gga tca gag gct cag ggt cca tcc gct 385 Pro Gly Arg Ala Ala Pro Thr Gly Ser Glu Ala Gln Gly Pro Ser Ala 115 120 125 ttt gta agg atg gag aag ggt atc cct gcc agt ccc cgc tgt ggc tca 433 Phe Val Arg Met Glu Lys Gly Ile Pro Ala Ser Pro Arg Cys Gly Ser 130 135 140 ccc aca gct atg gaa att gac aaa agg ggc tct cct acc ccg gga act 481 Pro Thr Ala Met Glu Ile Asp Lys Arg Gly Ser Pro Thr Pro Gly Thr 145 150 155 160 cgg agc tgc cta gct ccc tca ttg ggg ctg ttc gga gct agc tta acg 529 Arg Ser Cys Leu Ala Pro Ser Leu Gly Leu Phe Gly Ala Ser Leu Thr 165 170 175 atg gcc acg gaa gtg gca gcg aga gtt aca tcc act ggg cca cac cgt 577 Met Ala Thr Glu Val Ala Ala Arg Val Thr Ser Thr Gly Pro His Arg 180 185 190 cca cag gat ctt gcc ctc act gag ccg tct ggg aga gcc cgt gag ctt 625 Pro Gln Asp Leu Ala Leu Thr Glu Pro Ser Gly Arg Ala Arg Glu Leu 195 200 205 gag gac ctg cag ccc cca gag gcc ctg gtg gag agg cag ggg cag ttt 673 Glu Asp Leu Gln Pro Pro Glu Ala Leu Val Glu Arg Gln Gly Gln Phe 210 215 220 ctg ggc agt gag aca agc cca gcc cca gaa agg ggc ggg ccc cgc gat 721 Leu Gly Ser Glu Thr Ser Pro Ala Pro Glu Arg Gly Gly Pro Arg Asp 225 230 235 240 gga gaa ccc cct ggg aag atg ggg aaa gga tat ctg ccc tgt ggc atg 769 Gly Glu Pro Pro Gly Lys Met Gly Lys Gly Tyr Leu Pro Cys Gly Met 245 250 255 ccg ggc tct ggg gag cct gaa gtg ggc aaa agg cca gag gag acg act 817 Pro Gly Ser Gly Glu Glu Val Gly Lys Arg Pro Glu Glu Thr Thr 260 265 270 gtg agc gtg caa agc gca gag tcc tct gat gcc ctg agc tgg tcc agg 865 Val Ser Val Gln Ser Ala Glu Ser Ser Asp Ala Leu Ser Trp Ser Arg 275 280 285 ctg ccc agg gcc ctg gcc tcc gta ggc cct gag gag gcc cga agt ggg 913 Leu Pro Arg Ala Leu Ala Ser Val Gly Pro Glu Glu Ala Arg Ser Gly 290 295 300 gcc ccc gtg ggc ggg ggg cgt tgg cag ctc tcc gag gt gga 961 Ala Pro Val Gly Gly Gly Arg Trp Gln Leu Ser Asp Arg Val Glu Gly 305 310 315 320 ggg tcc cca acg ctg ggc ttg ctt ggg ggc agc ccc tca gca cag ccg 1009 Gly Ser Pro Thr Leu Gly Leu Leu Gly Gly Se r Pro Ser Ala Gln Pro 325 330 335 ggg acc ggg aat gtg gag gcg gga att cct tct ggc aga atg ctg gag 1057 Gly Thr Gly Asn Val Glu Ala Gly Ile Pro Ser Gly Arg Met Leu Glu 340 345 350 cct ttg ccc tgt tgg gac gct gcg aaa gat ctg aaa gaa cct cag tgc 1105 Pro Leu Pro Cys Trp Asp Ala Ala Lys Asp Leu Lys Glu Pro Gln Cys 355 360 365 cct cct ggg gac agg gtg ggt gtg cag cct ggg aac tcc agg gtt tgg 1153 Gly Asp Arg Val Gly Val Gln Pro Gly Asn Ser Arg Val Trp 370 375 380 cag ggc acc atg gag aaa gcc ggt ttg gct tgg acg cgt ggc aca ggg 1201 Gln Gly Thr Met Glu Lys Ala Gly Leu Ala Trp Thr Arg Gly Thr Gly 385 390 395 400 gtg caa tca gag ggg act tgg gaa agc cag cgg cag gac agt gat gcc 1249 Val Gln Ser Glu Gly Thr Trp Glu Ser Gln Arg Gln Asp Ser Asp Ala 405 410 415 ctc cca agt ccg gag ctg cta ccc caag cag gac aag cct ttc ctg 1297 Leu Pro Ser Pro Glu Leu Leu Pro Gln Asp Gln Asp Lys Pro Phe Leu 420 425 430 agg aag gcc tgc agc ccc agc aac ata cct gct gtc atc att aca gac 1345 Arg Lys Ala Cys Ser Pro Ser Asn Ile Pro Ala Val Ile Ile Thr Asp 435 440 445 atg ggc acc cag gag gat ggg gcc ttg gag gag acg cag gga agc cct 1393 Met Gly Thr Gln Glu Asp Gly Ala Leu Glu Glu Thr Gln Gly Ser Pro 450 455 460 cgg ggc aac ctg ccc ctg agg aaa ctg tcc tct tcc tcg gcc tcc tcc 1441 Arg Gly Asn Leu Pro Leu Arg Lys Leu Ser Ser Ser Ser Ala Ser Ser 465 470 475 475 480 acg ggc ttc tcc tca tcc tac gaa gac tca gag gag tcc agt 1489 Thr Gly Phe Ser Ser Ser Tyr Glu Asp Ser Glu Glu Asp Ile Ser Ser 485 490 495 gac cct gag cgc acc ctg gac ccc aac tca gcc ttc ctg cat acc ctg 1537 Asp Pro Glu Arg Thr Leu Asp Pro Asn Ser Ala Phe Leu His Thr Leu 500 505 510 gac cag cag aaa cct aga gtg gta agt ctt gct ctg aga ttt gcc cag 1585 Asp Gln Gln Lys Pro Arg Val Val Ser Leu Ala Leu Arg Phe Ala Gln 515 520 525 aac tca tgc tgatttcag tgatttgca atcccttttt 1634 Asn Ser Cys 530 cttaactttc tacacagtca tgaaaactca gaccagggcc ctgggacagt cacagtgaat 1694 aattctgtcc aggtgtgttt gctgaggtgg aagcagaggc actgaccatg cattttagct 1754 tggacagtga atctgagtct ttctactatt tccatgcata tcttaaaaaa caagttttaa 1814 aagtatttca tgtaggtcac cacgcttctt gggaaaataa tattcataaa tgtcaccaaa 1874 aacttctgga ctaatcccca aagatagtga actgagctac tgagtgtagt ttttgtctga 1934 tcaggtgaaa cacttaactc tgtgtttcat tcaggccaaa gaaaattgac aaggatatca 1994 tcaaattaag ttagcctcta ctaataagcc aggaaaatga gtgatgtgaa tctatgacag 2054 gaccctgaaa cctgtagatg tggttgtggc cagtcaactg ggtgaggaat cactgagcct 2114 cagtaagtta agccagacca ttgcaatatt tgtgtggtca gtgtaaccaa ggtgcagttt 2174 gatgtatgaa ttaaatgaaa accatacttt gagctaagca gatggtttct tcagtatcat 2234 aggcacctga gtgttatctc cggagtaggt acctcctaat ggatgtacat gtcagttggt 2294 acaggttgac atttcaggta tgttttcacg tgcctctggt ttgggtcatc acactgacat 2354 cttgttctgg ttatggcagt agacaggagt ttatttctat tacatggtta atcgaacttg 2414 taggctgctt ttactcttag gaggatcaga gtatcttaca gaagacatag gagttgaagc 2474 tagcacttct gaaaaggtct gggctttctc ttagcttttc cagagagcat ggggaatttc 2534 ctagttcagt gtgccagggg tggttgtgct atattggggg aaagtctgca ttttattata 2594 gtag gtagcc ttccgatttc atcttgaata tcaaatactc ttcactgtac ctcaataact 2654 ttctccacca cgactgggag ctttatgttt ctactctgca ttcttcacta aggtattttg 2714 gaccacaaaa catactcctc tctgattccc tattcacgaa tcacagtctg gatttttgaa 2774 gaccaggcat tccttttcat gaaactctgc tttttgctga tgatctggag gcaaatgtgt 2834 atgcaaaatc gccccaatca gcctggcatt ttgtggctag gacagggccc ctgggcatta 2894 tgcacctgct gtcaggcata ggcgcaccac ctttagaggg ggaagcggtc cacctggaag 2954 gggatggtgg tcaagggcag gtgggaaata cttctttctg aaggcatggg ccagatttct 3014 ctttctgccc agcagttaga ggtctactga ataagagatg gtcccccgtc ccatccctcc 3074 cagttgcttt tgaactcctg aagcatagct gaaacagcca aagtcacttt aacttgttcc 3134 ctgactgtcc attcaccctt tctagtggta gattagcaac ttctattggc tggttgtcaa 3194 aacagtttgt gtcccgatgt ttgaaaacgg ctcttgtcta gaagagaatt aacagggaga 3254 tcaataacga caggtgactt ttttttccat ttgccagaac gatgccattt gagaaaccag 3314 agggttaagt ggtgttttta agttagtgaa catatccaga ggtagaaacg aggccagcct 3374 gttgtccagt ctacctccca cctttaaaca ggttttcaga cacccgcaga gcagagccag 3434 ggaaaaatcc cctgccggct ttgctctctg aatcacatga gactggtggg aagtggggtg 3494 ggtgtgtgtg tgtgtgtgta ggggggtaag ggtgggtaac caactggaaa ttatgggatc 3554 ctagggactt ttgagctttg gttgagtgct tgcacgataa gcaaagtttt cttcttgtac 3614 agattgttac gctggagcct tatctgtgac acccaaacat cagctcattg ggtcaaaaat 3674 cacttgatta cctgcaatag atattttgtc tacagaaggc cagacatctt gatggagtga 3734 gtcttttggc tgggcctttc tgtgtttgat agataaaagc cccaccagct ctgtctgagg 3794 ttctaccaaa ctgatgtagc attctctttt ctggactttg ctgtgtctgt ccagctactg 3854 cacaacgcta tagctgcaca ctctcatgct tgctcacact tgcttacact tgccctcaca 3914 catgccctca cacatgctca cacttaccct cctatgctca cacaggttcc cccttgctca 3974 ccccactcac acaggtctga aatggcatgt tcagcgtttc agtcacataa ccaacccctg 4034 gccctcagac ccacactaga cactgagatt gtttctgtgc tgccctacct tcccacagag 4094 ttaagccttt cgggcctcct gtggcgcttt cttcatcctt gctgaggaat gagtgtgtat 4154 gacttggtgt gcaggcaggg ggtgacagta tatctgctta gtagggatca gacacttgaa 4214 atttgctcag aaatagttgc attacacgcc cagtgtgcaa tggctgaaat tcaggcacat 4274 tcatgcttac tgtt ctctga gatctgaaca aaatcaaatt gcactgagca aggatagtgc 4334 tcaatctttt gttctttctg acaactaaaa attaaccagc ggttgtttac ttccctatat 4394 aattctgttt aagagaatct ggaccattga gacatt gattacctattattagtattgattattagattattgattattagattattgattattagattattagattattagattattagattattagattagattattagattattagattattagattattagattattagattattgattagattattagattattatatttattattagtattagtattagattattatattgattattattattgattagatt <210> 119 <211> 4239 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2705) <400> 119 gt ttt gta act caa ctg gcc tgc ttc ctg gcc aac cag cag aac aaa 47 Phe Val Thr Gln Leu Ala Cys Phe Leu Ala Asn Gln Gln Asn Lys 1 5 10 15 tac aaa tat gaa gag tgc aaa gac ctc ata aaa tct atg ctg agg aat 95 Tyr Lys Tyr Glu Glu Cys Lys Asp Leu Ile Lys Ser Met Leu Arg Asn 20 25 30 gag cga cag ttc aag gag gag aag ctt gca gag cag ctc aag caa gct 143 Glu Arg Gln Phe Lys Glu Lys Leu Ala Glu Gln Leu Lys Gln Ala 35 40 45 gag gag ctc agg caa tat aaa gtc ctg gtt cac tct cag gaa cga gag 191 Glu Glu Leu Arg Gln Tyr Lys Val Leu Val His Ser Gln Glu Arg Glu 50 55 60 ctg acc cag tta agg gag aag tta cgg gaa ggg aga gat gcc tcc cgc 239 Leu Thr Gln Leu Arg Glu Lys Leu Arg Glu Gly Arg Asp Ala Ser Arg 65 70 75 tca ttg aat cag cat ctc cag gcc ctc ctc act ccg gat aag cag 287 Ser Leu Asn Gln His Leu Gln Ala Leu Leu Thr Pro Asp Lys Pro Asp 80 85 90 95 aag tcc cag ggg cag gac ctc caa gaa cag ctg gct gag ggg tgt aga 335 Lys Ser Gln Gly Gln Asp Leu Gln Glu Gln Leu Ala Glu Gly Cys Arg 100 105 110 ct g gca cag caa ctt ttc cag aag ctc agc cca gaa aat gac gaa gat 383 Leu Ala Gln Gln Leu Phe Gln Lys Leu Ser Pro Glu Asn Asp Glu Asp 115 120 125 gag gat gaa gat gtt caa gtt gag gag gct gag aaa gaa tca 431 Glu Asp Glu Asp Val Gln Val Glu Glu Ala Glu Lys Val Leu Glu Ser 130 135 140 tct gcc ccc agg gag gtg cag aag gct gaa gaa agc aaa gtc cct gag 479 Ser Ala Pro Arg Glu Val Gln Lys Ala Glu Glu Ser Lys Val Pro Glu 145 150 155 gac tca ctg gag gaa tgt gcc atc act tgt tca aat agc cac agc cct 527 Asp Ser Leu Glu Glu Cys Ala Ile Thr Cys Ser Asn Ser His Ser Pro 160 165 170 175 tgt gac tcc aac cag cct cac aag aac atc aac atc acc ttt gag gaa 575 Cys Asp Ser Asn Gln Pro His Lys Asn Ile Asn Ile Thr Phe Glu Glu 180 185 190 gac aaa gtc aac tca act ctg gtt gta gac aga gaa tcc tct cat gat 623 Asp Lys Val Asn Ser Thr Leu Val Val Asp Arg Glu Ser Ser His Asp 195 200 205 gaa tgt cag gat gct gta aac att ctc cca gtc cct ggc ccc acc tct 671 Glu Cys Gln Asp Ala Val Asn Ile Leu Pro Val Pro Gly Pro Thr Ser Two 10 215 220 tct gcc aca aac gtc agc atg gtg gta tca gcc ggc cct ttg tcc agc 719 Ser Ala Thr Asn Val Ser Met Val Val Ser Ala Gly Pro Leu Ser Ser 225 230 235 gag aag gca gag atg aac att cta gaa atc aac gag aaa ttg cat ccc 767 Glu Lys Ala Glu Met Asn Ile Leu Glu Ile Asn Glu Lys Leu His Pro 240 245 250 255 cag ctg gca gag aag aaa cag cag ttc aga aac ctc aaa gag aaa tgt 815 Gln Leu Ala Glu Lys Lys Gn Gln Phe Arg Asn Leu Lys Glu Lys Cys 260 265 270 ttt gta act caa ctg gcc tgc ttc ctg gcc aac cag cag aac aaa tac 863 Phe Val Thr Gln Leu Ala Cys Phe Leu Ala Asn Gln Gln Asn Lys Tyr aat 275 280 285 285 gaa gag tgc aaa gac ctc ata aaa tct atg ctg agg aat gag 911 Lys Asn Glu Glu Cys Lys Asp Leu Ile Lys Ser Met Leu Arg Asn Glu 290 295 300 cga cag ttc aag gag gag aag ctt gca gag cag ctag ag 959 Arg Gln Phe Lys Glu Glu Lys Leu Ala Glu Gln Leu Lys Gln Ala Glu 305 310 315 gag ctc agg caa tat aaa gtc ctg gtt cac tct cag gaa cga gag ctg 1007 Glu Leu Arg Gln Tyr Lys Val Leu Val His Ser GlnArg Glu Leu 320 325 330 335 acc cag tta agg gag aag tta cgg gaa ggg aga gat gcc tcc tgc tca 1055 Thr Gln Leu Arg Glu Lys Leu Arg Glu Gly Arg Asp Ala Ser Cys Ser 340 345 350 ttg aat cag cat ctc cag gcc ctc ctc act ccg gat gag cca gac aag 1103 Leu Asn Gln His Leu Gln Ala Leu Leu Thr Pro Asp Glu Pro Asp Lys 355 360 365 tcc cag ggg cag gac ctc caa gaa cag ctg gct gag ggg tgt aga ctg 1151 Ser Gln Gly Asp Leu Gln Glu Gln Leu Ala Glu Gly Cys Arg Leu 370 375 380 gca cag cac ctt gtc caa aag ctc agc cca gaa aat gac aac gat gac 1199 Ala Gln His Leu Val Gln Lys Leu Ser Pro Glu Asn Asp Asn Asp Asp 385 395 gat gaa gat gtt caa gtt gag gtg gct gag aaa gtg cag aaa tcg tct 1247 Asp Glu Asp Val Gln Val Glu Val Ala Glu Lys Val Gln Lys Ser Ser 400 405 410 415 gcc ccc agg gag atg ccg aag gct gaa gaaag gtc cct gag gac 1295 Ala Pro Arg Glu Met Pro Lys Ala Glu Glu Lys Glu Val Pro Glu Asp 420 425 430 tca ctg gag gaa tgt gcc atc act tgt tca aat agc cat ggc cct tat 1343 Ser Leu Glu Glu Cys Ala Ile Thr Cys Ser Asn Ser His Gly Pro Tyr 435 440 445 gac tcc aac cag cca cat agg aaa acc aaa atc aca ttt gag gaa gac 1391 Asp Ser Asn Gln Pro His Arg Lys Thr Lys Ile Thr Phe Glu Glu Asp 450 455 460 aaa gtc gac tca act ctc att ggc tca tcc tct cat gtt gaa tgg gag 1439 Lys Val Asp Ser Thr Leu Ile Gly Ser Ser Ser His Val Glu Trp Glu 465 470 475 gat gct gta cac att atc cca gaa aat gaa agt gat gat gag gaga gag 1487 Asp Ala Val His Ile Ile Pro Glu Asn Glu Ser Asp Asp Glu Glu Glu 480 485 490 495 gaa gaa aaa ggg cca gtg tct ccc agg aat ctg cag gag tct gaa gag 1535 Glu Glu Lys Gly Pro Val Ser Pro Arg Asn Leu Gln Glu Ser Glu Glu 500 505 510 gag gaa gtc ccc cag gag tcc tgg gat gaa ggt tat tcg act ctc tca 1583 Glu Glu Val Pro Gln Glu Ser Trp Asp Glu Gly Tyr Ser Thr Leu Ser 515 520 525 att cct cct gaa atg ttg cc tcg tac cag tct tac agc ggc aca ttt 1631 Ile Pro Pro Glu Met Leu Ala Ser Tyr Gln Ser Tyr Ser Gly Thr Phe 530 535 540 cac tca tta gag gaa cag caa gtc tgc atg gct gtt gac ata ggc gga 1679 His Ser L eu Glu Glu Gln Gln Val Cys Met Ala Val Asp Ile Gly Gly 545 550 555 cat cgg tgg gat caa gtg aaa aag gag gac caa gag gca aca ggt ccc 1727 His Arg Trp Asp Gln Val Lys Lys Glu Asp Gln Glu Ala Thr Gly Pro 560 565 570 575 agg ctc agc agg gag ctg ctg gat gag aaa ggg cct gaa gtc ttg cag 1775 Arg Leu Ser Arg Glu Leu Leu Asp Glu Lys Gly Pro Glu Val Leu Gln 580 585 590 590 gac tca ctg gat tac tgt tca ggt tat ctt gaa ctg 1823 Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Tyr Leu Glu Leu 595 600 605 act gac tca tgc cag ccc tac aga agt gcc ttt tac ata ttg gag caa 1871 Thr Asp Ser Cys Gln Pro Tyr Arg Ser Ala Phe Tyr Ile Leu Glu Gln 610 615 620 cag cgt gtt ggc tgg gct ctt gac atg gat gaa att gaa aag tac caa 1919 Gln Arg Val Gly Trp Ala Leu Asp Met Asp Glu Ile Glu Lys Tyr Gln 630 gt 630 630 g gaa gaa gac caa gac cca tca tgc ccc agg ctc agc agg gag 1967 Glu Val Glu Glu Asp Gln Asp Pro Ser Cys Pro Arg Leu Ser Arg Glu 640 645 650 650 655 ctg ctg gat gag aaa gag cct gaa gtc ttg cag g gat aga 2015 Leu Leu Asp Glu Lys Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg 660 665 670 tgt tat tcg act cct tca ggt tat ctt gaa ctg cct gac tta ggc cag 2063 Cys Tyr Ser Thr Pro Ser Gly Tyr Leu Glu Leu Pro Asp Leu Gly Gln 675 680 685 ccc tac aga agt gct gtt tac tca ttg gag gaa cag tac ctt ggc ttg 2111 Pro Tyr Arg Ser Ala Val Tyr Ser Leu Glu Glu Gln Tyr Leu Gly Leu 690 695 700 gct ctt gac gtg aga att aaa aag gac caa gaa gag gaa gaa gac 2159 Ala Leu Asp Val Asp Arg Ile Lys Lys Asp Gln Glu Glu Glu Glu Asp 705 710 715 caa ggc cca cca tgc ccc agg ctc agc agg gag ctg gct gag 207 Pro Pro Cys Pro Arg Leu Ser Arg Glu Leu Leu Glu Ala Val 720 725 730 735 gag cct gaa gtc ttg cag gac tca ctg gat aga tgt tat tca act cct 2255 Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro 740 745 750 tcc agt tgt ctt gaa cag cct gac tcc tgc ctg ccc tat gga agt tcc 2303 Ser Ser Cys Leu Glu Gln Pro Asp Ser Cys Leu Pro Tyr Gly Ser Ser 755 760 760 ttt tat gca ttg gag gaa aaa cat gtt ggc ttt tct ctt gac gtg gga 2351 Phe Tyr Ala Leu Glu Glu Lys His Val Gly Phe Ser Leu Asp Val Gly 770 775 780 gaa att gaa aag aag ggg aag ggg aag aaa aga agg gga aga aga tca 2399 Glu Ile Glu Lys Lys Gly Lys Lys Arg Arg Gly Arg Arg Ser 785 790 795 acg aag aaa aga agg aga agg gga aga aaa gaa ggg gaa gaa gat caa 2447 Thr Lys Lys Arg Arg Arg Arg Arg Gly Arg Lys Glu Gly Glu Glu Asp G815 800 805 aac cca cca tgc ccc agg ctc agc ggt gtg ctg atg gaa gtg gaa gag 2495 Asn Pro Pro Cys Pro Arg Leu Ser Gly Val Leu Met Glu Val Glu Glu 820 825 830 cct gaa gtc tta cag gac tca ctg tatg ccg tca 2543 Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser 835 840 845 atg ttc ttt gaa cta cct gac tca ttc cag cac tac aga agt gtg ttt 2591 Met Phe Phe Glu Leu Pro Asp Ser Phe Gln His Tyr Arg Ser Val Phe 850 855 860 tac tca ttt gag gaa cag cac atc agc ttc gcc ctt gac gtg gac aat 2639 Tyr Ser Phe Glu Glu Glu His Inle Ser Phe Ala Leu Asp Val Asp Asn 865 870 875 agg ttt ctt act ttg atg gga aga agt ctc cac ctg gtc ttc cag atg 2687 Arg Phe Leu Thr Leu Met Gly Arg Ser Leu His Leu Val Phe Gln Met 880 885 890 895 gga gtc ata ttc cca caa taagcagccc ttactaagc Gagaggt Ggaggtat Gagly attcctgcag gcaggaccta taggcacgtg aagatttgaa tgaaactata gttccatttg 2795 gaagcccaga cataggatgg gtcagtgggc atggctctat tcctattctc agaccatgcc 2855 agtggcaacc tgtgctcagt ctgaagacaa tggacccaag ttaggtgtga cacgttcaca 2915 taactgtgca gcacatgccg ggagtgatca gtcagacatt ttaatttgaa ccacgtatct 2975 ctgggtagct acaaagttcc tcagggattt cattttgcag gcatgtctct gagcttctat 3035 acctgctcaa ggtcagtgtc atctttgtgt ttagctcatc caaaggtgtt accctggttt 3095 caatgaacct aacctcattc tttgtatctt cagtgttgaa ttgttttagc tgatccatct 3155 ttaacgcagg agggatcctt ggctgaggat tgtatttcag aaccaccaac tgctcttgac 3215 aattgttaac ccgctaggct cctttggtta gagaagccac agtccttcag cctccaattg 3275 gtgtcagtac ttaggaagac cacagac ttaggaagacgag agcat gagtagcagcagtag gagtagcagtag gagtagcc agac 395 atgtcaccca ggactctgcc ggtgcagaat atgaacaacg ccatgttctt gcagaaaacg 3455 cttagcctga gtttcatagg aggtaatcac cagacaactg cagaatgtag aacactgagc 3515 aggacaactg acctgtctcc ttcacatagt ccatatcacc acaaatcaca caacaaaaag 3575 gagaagagat attttgggtt caaaaaaagt aaaaagataa tatagctgca tttctttagt 3635 tattttgaac cccaaatatt tcctcatctt tttgttgttg tcattgatgg tggtgacatg 3695 gacttgttta tagaggacag gtcagctgtc tggctcagtg atctacattc tgaagttgtc 3755 tgaaaatgtc ttcatgatta aattcagcct aaacgttttg ccgggaacac tgcagagaca 3815 atgctgtgag tttccaacct tagcccatct gcgggcagag aaggtctagt ttgtccatca 3875 gcattatcat gatatcagga ctggttactt ggttaaggag gggtctagga gatctgtccc 3935 ttttagagac accttactta taatgaagta tttgggaggg tggttttcaa aagtagaaat 3995 gtcctgtatt ccgatgatca tcctgtaaac attttatcat ttattaatca tccctgcctg 4055 tgtctattat tatattcata tctctacgct ggaaactttc tgcctcaatg tttactgtgc 4115 ctttgttttt gctagtttgt gttgttgaaa aaaaaaacat tctctgcctg agttttaatt 4175 tttgtccaaa gttattttaa tctatacaat taaaagcttt tgcctctaga tcgcgggcgg 4235 c cgc 4239 <210> 120 <211> 4404 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (3522) <400> 120 agc gaa gcc aac tgc agc tgg gat aaa gtg ata ata gat agg act gac 48 Ser Glu Ala Asn Cys Ser Trp Asp Lys Val Ile Ile Asp Arg Thr Asp 1 5 10 15 aag gag gcg tgg cct tcc atc aca gga aca gag act gaa tct gcc tca 96 Lys Glu Ala Trp Pro Ser Ile Thr Gly Thr Glu Thr Glu Ser Ala Ser 20 25 30 gaa tgt act aca gac act gac tct gcc tcc aac tgt ggc tca gag aac 144 Glu Cys Thr Thr Asp Thr Asp Ser Ala Ser Asn Cys Gly Ser Glu Asn 35 40 45 agt agc atg gct aca ggg agt gcc cag ggc aac ttc act gga cat acc 192 Ser Ser Met Ala Thr Gly Ser Ala Gln Gly Asn Phe Thr Gly His Thr 50 55 60 aag aag aca aat ggc aat aat ggc acc aat ggc gca ctc gtc caa agc 240 Lys Lys Thr Asn Gly Asn Asn Gly Thr Asn Gly Ala Leu Val Gln Ser 65 70 75 80 cct tct aat cag agt gcc ctt gga gca ggg gga gcg agt aat gga 288 Pro Ser Asn Gln Ser Ala Leu Gly Ala Gly Gly Ala Asn Ser Asn Gly 85 90 95 agt gcg gcc aga gtg tgg ggt gta gcc aca ggc tcc agc tct ggc ctg 336 Ser Ala Ala Arg Val Trp Gly Val Ala Thr Gly Ser Ser Ser Gly Leu 100 105 1 10 gct cac tgc tct gtc agt ggt ggg gat gga aaa atg gac act atg att 384 Ala His Cys Ser Val Ser Gly Gly Asp Gly Lys Met Asp Thr Met Ile 115 120 125 gga gat ggg aga agt cag aat tgc tgg ggt gct tcc aac tcc aat gct 432 Gly Asp Gly Arg Ser Gln Asn Cys Trp Gly Ala Ser Asn Ser Asn Ala 130 135 140 ggc att aat ctt aac ctt aat cct aat gcc aac cca gct gcc tgg cct 480 Gly Ile Asn Leu Asn Leu Asn Pro Asn Ala Asn Pro Ala Ala Trp Pro 145 150 155 160 gta ctt gga cat gaa gga acc gtg gcg aca ggc aac cct tcc agt att 528 Val Leu Gly His Glu Gly Thr Val Ala Thr Gly Asn Pro Ser Ser Ile 165 170 175 tgc agt cca gtc agt gcc ata ggt caa aat atg ggc aac cag aac ggg 576 Cys Ser Pro Val Ser Ala Ile Gly Gln Asn Met Gly Asn Gln Asn Gly 180 185 190 aac cca aca ggc act tta ggt gct tgg gga aac ttg ctg cca caa gag 624 Asn Pro Thr Gly Thr Leu Gly Ala Trp Gly Asn Leu Leu Pro Gln Glu 195 200 205 agc aca gaa cca caa acg tcc act tct cag aat gtg tct ttc agc gca 672 Ser Thr Glu Pro Gln Thr Ser Thr Ser Gln Asn Val Ser Phe SerAla 210 215 220 caa cct cag aac ctt aac act gat gga cca aat aac act aac ccc atg 720 Gln Pro Gln Asn Leu Asn Thr Asp Gly Pro Asn Asn Thr Asn Pro Met 225 230 235 240 aac tct tca ccc aac cct atc aat gca atg cag aca aat gga ctg cca 768 Asn Ser Ser Pro Asn Pro Ile Asn Ala Met Gln Thr Asn Gly Leu Pro 245 250 255 aac tgg ggc atg gct gtt ggt atg ggg gcc atc atc ccg ccc cac ctg 816 Asn Trp Gly Met Ala Val Gly Met Gly Ala Ile Ile Pro Pro His Leu 260 265 270 caa ggc ctt cct ggt gct aat gga tca tca gtt tct caa gtc agt ggg 864 Gln Gly Leu Pro Gly Ala Asn Gly Ser Ser Val Ser Gln Val Ser Gly 275 280 285 285 ggc agt gct gaa gga ata agc aat tct gtg tgg gga ctg tcc cca ggt 912 Gly Ser Ala Glu Gly Ile Ser Asn Ser Val Trp Gly Leu Ser Pro Gly 290 295 300 aac cct gcc aca gga aat agc aat tct ggg ttc agt cag ggg gga 960 Asn Pro Ala Thr Gly Asn Ser Asn Ser Gly Phe Ser Gln Gly Asn Gly 305 310 315 320 gac act gtg aac tca gca tta agt gct aaa caa aat gga tcc agc agt 1008 Asp Thr Val Asn Ser Ala Leu Ser Ala Lys Gln Asn Gly Ser Ser Ser 325 330 335 gct gtg caa aag gaa gga agt gga gga aat gct tgg gat tca gga cct 1056 Ala Val Gln Lys Glu Gly Ser Gly Gly Asn Ala Trp Asp Ser Gly Pro 340 345 350 cct gct ggt cct gga ata ctc gcc tgg gga agg ggc agt ggc aac aat 1104 Pro Ala Gly Pro Gly Ile Leu Ala Trp Gly Arg Gly Ser Gly Asn Asn 355 360 365 ggc gtt ggt aat atc cat tca gga gct tgg ggc cac ccc agc cga agc Gly 1152 Gly Asn Ile His Ser Gly Ala Trp Gly His Pro Ser Arg Ser 370 375 380 acc tct aac ggt gtg aat ggg gaa tgg gga aag ccc cca aac cag cat 1200 Thr Ser Asn Gly Val Asn Gly Glu Trp Gly Lys Pro Pro Asn Gln His 385 390 395 400 tcc aac agt gac atc aat ggg aaa gga tca aca ggg tgg gag agt cct 1248 Ser Asn Ser Asp Ile Asn Gly Lys Gly Ser Thr Gly Trp Glu Ser Pro 405 410 415 agt gtc acc agc cag aac cct acc gta cag cct ggt ggt gaa cac atg 1296 Ser Val Thr Ser Gln Asn Pro Thr Val Gln Pro Gly Gly Glu His Met 420 425 430 aac tcc tgg gcc aaa gcg gca tct tct gga act aca gca agt gaa gga 1344 Asn Ser Trp Ala Lys Ala Ala Ser Ser Gly Thr Thr Ala Ser Glu Gly 435 440 445 agt agt gat ggt tct ggc aac cac aat gaa gga agc act ggg agg gaa 1392 Ser Ser Asp Gly Ser Gly Asn His Asn Glu Gly Ser Thr Gly Arg Glu 450 455 460 gga acg gga gaa ggc cga agg cga gat aaa ggg att ata gac caa ggg 1440 Gly Thr Gly Glu Gly Arg Arg Arg Asp Lys Gly Ile Ile Asp Gln Gly 465 470 475 475 480 cac atc cag ttg cca agg aat gat ctt gac cca g tct aat 1488 His Ile Gln Leu Pro Arg Asn Asp Leu Asp Pro Arg Val Leu Ser Asn 485 490 495 act ggt tgg gga cag act cct gta aag caa aac act gcc tgg gaa ttt 1536 Thr Gly Trp Gly Gln Thr Pro Val Lys Gln Asn Thr Ala Trp Glu Phe 500 505 510 gaa gaa tcc cct agg tct gaa agg aaa aat gac aat ggg aca gag gcc 1584 Glu Glu Ser Pro Arg Ser Glu Arg Lys Asn Asp Asn Gly Thr Glu Ala 515 520 525 525 tgg ggt tgt gca gct act cag gct tca aac tca ggg ggg aag aac gat 1632 Trp Gly Cys Ala Ala Thr Gln Ala Ser Asn Ser Gly Gly Lys Asn Asp 530 535 540 ggg tcc atc atg aac agt aca aat acc tct tca gta tct ggg tgg gtc 1680 Gly Ser Ile Met Asn Ser Thr Asn Thr Ser Ser Val Ser Gly Trp Val 545 550 555 560 aac gcg cca cct gcc gct gtg cca gca aac aca ggt tgg gga gac agc 1728 Asn Ala Pro Pro Ala Ala Val Pro Ala Asn Thr Gly Trp Gly Asp Ser 565 570 575 aac aac aaa gcg cca agt ggc ccg ggg gtt tgg ggg gac tcg ata agc 1776 Asn Asn Lys Ala Pro Ser Gly Pro Gly Val Trp Gly Asp Ser Ile Ser 580 585 590 590 tct act gct gtt agt act gct gct gct gcc aag agt ggc cat gct tgg 1824 Ser Thr Ala Val Ser Thr Ala Ala Ala Ala Lys Ser Gly His Ala Trp 595 600 605 agt ggg gcc gca aat cag gag gac aag tca ccc acc tgg ggt gag cct 1872 Ser Gly Ala Ala Asn Gln Glu Asp Lys Ser Pro Thr Trp Gly Glu Pro 610 615 620 cca aag ccc aaa tcc caa cac tgg gga gat gga caa aga tca aat cca 1920 Pro Lys Pro Lys Ser Gln His Trp Gly Asp Gly Gln Arg Ser Asn Pro 625 630 635 640 gcc tgg agt gca gga ggg gga gat tgg gca gat tca tcg tct gtc ctt 1968 Ala Trp Ser Ala Gly Gly Gly Asp Trp Ala Asp Ser Ser Ser Val Leu 645 650 650 655 gga cac ttg ggg gat ggg aaa aaa aat gga tct gga tgg gat gct gac 2016 Gly His Leu Gly Asp Gly Lys Lys Asn Gly Ser Gly Trp Asp Ala Asp 660 665 670 agt aat agg tca ggg tct ggt tgg aat gac acc acg aga tct ggg aac 2064 Ser Asn Arg Ser Gly Ser Gly Trp Asn Asp Thr Thr Arg Ser Gly Asn 675 680 685 agt ggc tgg ggc aac agc aca aat aca aag gcc aat cca ggt aca aac 2112 Ser Gly Trp Gly Asn Ser Thr Asn Thr Lys Ala Asn Pro Gly Thr Asn 690 695 700 tgg ggg gag act tta aaa cct ggc ccc caa cag aac tgg gct agc aaa 2160 Trp Gly Glu Thr Leu Lys Pro Gly Pro Gln Gln Asn Trp Ala Ser Lys 705 710 715 720 ccc caa gac aac aat gtg agt aac tgg gga gga gct gct tct gtg aaa Pro Gln Asp Asn Asn Val Ser Asn Trp Gly Gly Ala Ala Ser Val Lys 725 730 735 cag aca gga aca ggg tgg atc ggg ggg ccg gta ccg gtc aaa cag aag 2256 Gln Thr Gly Thr Gly Trp Ile Gly Gly Pro Val Pro Val Lys Gln Lys 740 745 750 gac agc agt gaa gca act ggc tgg gaa gaa ccc tct cca ccg tcc att 2304 Asp Ser Ser Glu Ala Thr Gly Trp Glu Glu Pro Ser Pro Pro Ser Ile 755 760 765 cgc cgc aaa atg gaa att gat gat at ggt acc tca gct tgg ggg gac cca 2352 Arg Arg Lys Met Glu Ile Asp Asp Gly Thr Ser Ala Trp Gly Asp Pro 770 775 780 agc aac tat aac aat aaa act gta aac atg tgg gat aga aac aac ccg 2400 Ser Asn Tyr Asn Asn Lys Thr Val Asn Met Trp Asp Arg Asn Asn Pro 785 790 795 800 gtc atc cag agc agt acc acg acc aat acc acc acc acc acc acc act 2448 Val Ile Gln Ser Ser Thr Thr Thr Thr Asn Thr Thr Thr Thr Thr Thr Thr 805 810 815 acc acg agc aac acc aca cac agg gtc gag acg ccg ccc ccg cac cag 2496 Thr Thr Ser Asn Thr Thr His Arg Val Glu Thr Pro Pro Pro His Gln 820 825 830 gcc ggt act cag ctg aat cga tca ccg ttg ctt ggt cca gtt tca tca 2544 Ala Gly Thr Gln Leu Asn Arg Ser Pro Leu Leu Gly Pro Val Ser Ser 835 840 845 ggc tgg gga gaa atg cct aat gtt cac tca aag act gaa aac tct tgg 2592 Gly Trp Gly Glu Mlu Pro Asn Val His Ser Lys Thr Glu Asn Ser Trp 850 855 860 gga gaa cca tcc tcc cct tct acc ctg gtg gat aat ggc aca gca gca 2640 Gly Glu Pro Ser Ser Pro Ser Thr Leu Val Asp Asn Gly Thr Ala Ala 865 870 875 880 880 tgg g gg aag cca ccc agc agt ggc agc ggg tgg gga gat cac cct gca 2688 Trp Gly Lys Pro Pro Ser Ser Gly Ser Gly Trp Gly Asp His Pro Ala 885 890 895 gag ccg ccg gtg gca ttt gga aga gct ggc gca cct gtt tca 2736 Glu Pro Pro Val Ala Phe Gly Arg Ala Gly Ala Pro Val Ala Ala Ser 900 905 910 gcc ctg tgc aaa cca gct tca aaa tct atg caa gaa ggc tgg ggc agt 2784 Ala Leu Cys Lys Pro Ala Ser Lys Ser Met Gln Glu Gly Trp Gly Ser 915 920 925 ggt ggg gat gaa atg aac ctc agt acc agc cag tgg gag gat gaa gaa 2832 Gly Gly Asp Glu Met Asn Leu Ser Thr Ser Gln Trp Glu Asp Glu Glu 930 935 940 ggg gac gtg ggg aat gct tcc caa gaa agc acc tcc tcc tgc 2880 Gly Asp Val Trp Asn Asn Ala Ala Ser Gln Glu Ser Thr Ser Ser Cys 945 950 955 960 agc tcc tgg ggg aac gcc ccc aaa aaa gga ctt caa aag ggc atg aag 2928 Ser Ser Trp Gly Asn Ala Pro Lys Lys Gly Leu Gln Lys Gly Met Lys 965 970 975 acg tct ggc aag cag gat gag gcc tgg atc atg agc cgg ctg atc aaa 2976 Thr Ser Gly Lys Gln Asp Glu Ala Trp Ile Met Ser Arg Leu Ile Ly s 980 985 990 caa ctc aca gac atg ggc ttc ccg aga gag cca gct gag gag gcc ttg 3024 Gln Leu Thr Asp Met Gly Phe Pro Arg Glu Pro Ala Glu Glu Ala Leu 995 1000 1005 aag agt aac aat atg aat gtt gat ca atg agc gct ctg ctg gaa 3072 Lys Ser Asn Asn Met Asn Leu Asp Gln Ala Met Ser Ala Leu Leu Glu 1010 1015 1020 aag aag gtg gac gtg gac aag cgt ggg ctg gga gtg acc gac cat aat 3120 Lys Lys Val Asp Arg Gly Leu Gly Val Thr Asp His Asn 1025 1030 1035 1040 gga atg gcc gcc aag ccc ctc ggc tgc cgc ccg cca atc tcc aaa gag 3168 Gly Met Ala Ala Lys Pro Leu Gly Cys Arg Pro Pro Ile Ser Lys Glu 1045 1050 1055 t tcc gtg gac cgc ccc acc ttt ctt gac aag gat ggc ggc ctc gtg 3216 Ser Ser Val Asp Arg Pro Thr Phe Leu Asp Lys Asp Gly Gly Leu Val 1060 1065 1070 gaa gag ccc acg cct tca ccg ttc ttg cct ccc ag ctc 3264 Glu Glu Pro Thr Pro Ser Pro Phe Leu Pro Ser Pro Ser Leu Lys Leu 1075 1080 1085 ccc ctt tca cac agt gca ctc ccc agt cag gcc ctg ggt ggg att gcc 3312 Pro Leu Ser His Ser Ala Leu Pro Ser Gln Ala Leu Gly Gly Ile Ala 1090 1095 1100 tcc ggg ctg ggc atg caa aac ttg aat tct tct aga cag ata ccg agt 3360 Ser Gly Leu Gly Met Gln Asn Leu Asn Ser Ser Arg Gln Ile Pro Ser 1105 1110 1115 1120 ggc aat ctg ggt atg ttt ggc aat agt gga gca gca caa gcc agg acc 3408 Gly Asn Leu Gly Met Phe Gly Asn Ser Gly Ala Ala Gln Ala Arg Thr 1125 1130 1135 atg cag cag ccg cca cag cca cca gtg cag cct ctt tcc cag 3456 Met Gln Gln Pro Pro Gln Pro Pro Val Gln Pro Leu Asn Ser Ser Gln 1140 1145 1150 ccc agt ctc cgt gct caa gtg cct cag ttt cta tcc cct cag gtc aga 3504 Pro Ser Leu Arg Ala Gln Val Pro Gln Phe Leu Ser Pro Gln Val Arg 1155 1160 1165 ccc aca tcc aag cag gac tgagcaacag gatatagatg ccagtgtttc 3552 Pro Thr Ser Lys Gln Asp 1170 gtggggtcct gtgttatctg gaagtcacta ttttaaagtg agagcggagt taatccatgt 3612 ttaagagaag gccttctggt ttttaaccta taaattaatt ttagactata aagtagtaaa 3672 tggattctcc tgacccagga gacattttca gagcttgctc cttggaatgc ctcagccacc 3732 gaaactagca tttggcatct tcctggtcag aagcaatatt gagggggaag gacctgccca 3792 acacactccc attgatgtgc ttttgtccca gtctttgtcg agaaaattat tcaggtgaac 3852 ccagtgaact gtcctagatt ggtgggagag gaaagtgaca cgctgtagta ttgctgagga 3912 tgtaaaagaa acccttagaa gcagccaagg actgaatcat gctttaatga gaaactaaat 3972 gtgatctcat ataatagtgt atatattata gattttcagt tatgtttaat attcagaatt 4032 agatcatttt tgccaataga gttgggtttt ttttctttct ttcatccctt ttcaggagtg 4092 aaccatagag attgttaaga aaaaaatgtt gccgggcgcg gcggctcacg cctgtaatcc 4152 cagcactttg ggaggccgag gtgggtggat cacctgaggt caggagttcg agaccagcct 4212 ggccaatatg gcgaaacccc atctctacta aaaatacaaa attagccagg tgtggtggcg 4272 catgcctgtg atcccagcta cttgggaggc tgaggcagga gaatcgcttg acccggggag 4332 gtggagattg cggtgagccc agat agccatg agccatg agatcagccatg acctgagccagc agatcgagcagagccagag agatcc gaggacccagag agatcc gaggacccagagagccagag atg <210> 121 <211> 4832 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2770) .. (4227) <400> 121 ggcaacttca atctatgctc ccagtgaaaa aataataatt aaaaagtgat aacttaggcc 60 aggcgcagtg gctcatgcca gtaatcccag cactttggga ggccaaggcg ggcagatcac 120 ctgaggtcga gagtttgaga ccagcctgac caacatgaag aaaccccgtc tctactaaaa 180 atacaaaatt agccgggtgt ggtggtgcat gcctgtaatc ccagctactt gagaggctga 240 ggcaggagaa tcgcttgaac ccaggaggtt caaccggagg ttgcagtgag ctgagattgc 300 gccatggcac tccagcctgg gcaacaagag cgaaactccg tctcaaaaaa taataataat 360 aacttgacct ttagaagtcg taagcataca tattatacta cataccatgg gtcaggatga 420 accacctgag tagtgaaagt ggagaggagg actgagacct agggcactct aatacatgga 480 agatagaggg atgagaagag tctagcacag aagagcgagg ctcagtcagc aaggaaagaa 540 gagaacggag aagcatgtcc tagaagacaa gggaggaaga tgtttttagg aggaaggaag 600 aattgtgtca attgtcacag ctaggttaag aaagatgaag agtgagaact gttcattgaa 660 tttggctgca tggaggtcat tgggaagctc cattgttagg agctcagccc agtgatatgt 720 atagaagcat tactggaaat gttcaagaga gagggcagtg tcattaaaaa aatggaggcc 780 aggcacagtg gctcaacacc tgtagtccca gcactttggg aggctgaggc gggaggattg 840 cttgaggcca ggagtttaag accagcctgg acaacatagc aagaccccat ctcaaaaaaa 900 aaaattagct gtgtgtagtg acacaactac tcaggagact gaggcaggag gatcatttta 960 gcccaggact ttgaagttac agtgagccaa gatcatgcca ctgcattcca gcctggacaa 1020 cagagcaaga ccctgcctca aaaaaaaaaa aaaaaaaatt aaagagtata tgtgaggcca 1080 ggtgcagtgg ttcacggctg taatcctagc attttgggag gctgagtcgg gtggatcgct 1140 taagctcagg agtttgagac cagcctgggc aacatggcaa gactgcctct actaaaaata 1200 caaaaaaata gctgggcaaa aaaatagctg accgtgcttg tggtcccagc ttctcaggag 1260 gctgaggtgg gaggatcgtt tgagcctggc aggtggaggt tgcagtaagc caagattgca 1320 ccactgtact ccagcctggg caacagagac cctatctcaa aacaaacaaa aaagtgtatg 1380 tgtgtgtgtt cggtgtatgt gtaaagagag agagaggcag acaaaaatgt taaactatta 1440 acagttgttt aggtgaagga tacattgggt attcattgta ccacttttcc aacttgtctg 1500 tatggaattt tttcaaaaag aactggaggg ataagaaaag agtaaatggg aagaaaggaa 1560 atggaaacaa taactaaagg gtctgcatgt cttgcaaaga gaagcaatga aatggggcat 1620 tggagggaaa tatgagagtc aaggttttca ttttttgttt gaattctgta gagaatgcag 1680 ctgatagtca tgatcca ata cagaggaaaa actgatctag cagagagagg gaactgacga 1740 tgtagtttct acttacacat caaagtctgg ctccttaata acaaggaagt tattatttct 1800 aataattcca tccaaaaata aattgttaaa acagttaatc ataatcttac attatttaat 1860 gtcttttttt ctgcttaaat agcaatattt tttgacttgt tttctgcagg ttgtaggaag 1920 tgtcctgtat tttactaatt tttgccttga taaattgggg caaccgcttc taaatgaaaa 1980 ccctcagctt tccgaaggat gggaaatacc caagtatcct acatagtgaa tgaagatctt 2040 ttatgcatct tgccactaag ttcaccttta aaacaatttc caaattttgc agaccatgat 2100 aactattcct taataaaatt cactaaaggt accatcaagt cttcagccac attgtttctc 2160 tagaagggca agaaatacaa gtaaaggcaa aaaggtttgt gtggggagtt gttttgtttt 2220 acttatttac ttttttaacc aaaatcataa acttttggct tgaaaagttc atgttcttta 2280 ctgctggttt actctaaggt taattacaga ttgagctaga attttaatcc atacatatat 2340 gttaaatgtt taaatgaatc atctgcttcc tggaattcat tggttctcac ctaatgtgcc 2400 tgggtgggtg gaaaggtata attgttgctg tcaatttgat tgcagtctta taaccatctg 2460 ccttctttcc atgttaccta acggaaatat gatcaatgtg ttcaccttga ttcttcgttg 2520 ttaaccactg aaaaaactca a aagaggtaa cagatcagtc aggaacagaa gggttcttgg 2580 ttaaaagact ctgcatagta ctatttaaat cactaaataa aggagattaa agtgtacttc 2640 ttgttgcaga tattagtgat ctgtgatcaa cttgctttct tgtctctctg atacactttg 2700 ctgtcatata gaattttatt gatttgcttt tctattttta ttgacattat aaaaatcttt 2760 gtcttttga cca aat agg cca aag cct cac tgt ttc aat tgt ggt tct gaa 2811 Pro Asn Arg Pro Lys Pro His Cys Phe Asn Cys Gly Ser Glu 1 5 10 gaa cac caa atg aaa gat tgc cca atg cct cgg aat gct gct cga ata 2859 Glu His Gln Met Lys Asp Cys Pro Met Pro Arg Asn Ala Ala Arg Ile 15 20 25 30 agt gaa aag aga aaa gag tat atg gat gcc tgt gga gaa gca aac aat 2907 Ser Glu Lys Arg Lys Glu Tyr Met Asp Ala Cys Gly Glu Ala Asn Asn 35 40 45 cag aat ttc cag cag cga tac cac gca gaa gaa gta gaa 29 Asn Phe Gln Gln Arg Tyr His Ala Glu Glu Val Glu Glu Arg Phe 50 55 60 gga aga ttc aag cca gga gtt att agt gag gaa ctt caa gat gca cta 3003 Gly Arg Phe Lys Pro Gly Val Ile Ser Glu Glu Leu Gln Asp Ala Leu 65 70 75 ggt gtg aca gac aag agt ctt cca cc t ttt atc tat cgg atg cgc cag 3051 Gly Val Thr Asp Lys Ser Leu Pro Pro Phe Ile Tyr Arg Met Arg Gln 80 85 90 cta ggg tac cca cca ggg tgg ctc aaa gag gct gaa ttg gag aat tcg 3099 Leu Gly Tyr Pro Pro Gly Trp Leu Lys Glu Ala Glu Leu Glu Asn Ser 95 100 105 110 ggg ctt gca ctc tat gat gga aaa gat ggc act gat ggg gaa aca gaa 3147 Gly Leu Ala Leu Tyr Asp Gly Lys Asp Gly Thr Asp Gly Glu Thr Glu 115 120 125 gtt gga gaa ata caa cag aat aaa agt gtc act tac gat ctc tca aaa 3195 Val Gly Glu Ile Gln Gln Asn Lys Ser Val Thr Tyr Asp Leu Ser Lys 130 135 140 ttg gtc aac tat cct ggt ttt aat ata tct act ccc aga gga att cca 3243 Leu Val Asn Tyr Pro Gly Phe Asn Ile Ser Thr Pro Arg Gly Ile Pro 145 150 155 gac gaa tgg agg atc ttt ggt tcc ata cca atg cag gca tgt cag cag 3291 Asp Glu Trp Arg Ile Phe Gly Ser Ile Pro Met Gln Ala Cys Gln Gln 160 165 170 aag gat gtg ttt gcc aat tac ctt act tct aac ttc caa gcg cca ggt 3339 Lys Asp Val Phe Ala Asn Tyr Leu Thr Ser Asn Phe Gln Ala Pro Gly 175 180 185 190 gtg aag tct gg c aac aag agg tct tca tct cac tct agc cca ggt agt 3387 Val Lys Ser Gly Asn Lys Arg Ser Ser Ser His Ser Ser Pro Gly Ser 195 200 205 cca aag aag cag aag aat gaa agc aac tca gcg gga tct ccc gcc gac 3435 Pro Lys Lys Gln Lys Asn Glu Ser Asn Ser Ala Gly Ser Pro Ala Asp 210 215 220 atg gag ctc gat tca gat atg gag gta cca cat ggt tct cag agc agc 3483 Met Glu Leu Asp Ser Asp Met Glu Val Pro His Gly Ser Gln Ser Ser 225 230 235 gaa agt ttt cag ttt caa cca cca tta cct cct gac act cct cca ctc 3531 Glu Ser Phe Gln Phe Gln Pro Pro Leu Pro Pro Asp Thr Pro Pro Leu 240 245 250 ccc cgg gga act cct cca ccc gtc ttc acc cct cca ctc cca aag ggc 3579 Pro Arg Gly Thr Pro Pro Pro Val Phe Thr Pro Pro Leu Pro Lys Gly 255 260 265 270 acc ccg ccg ctg act ccc agt gac tca ccc cag acc aga aca gca tct 3627 Thr Pro Pro Leu Thr Pro Ser Asp Ser Pro Gln Thr Arg Thr Ala Ser 275 280 285 gga gct gtg gat gag gac gca ctg act cta gaa gaa ctt gaa gaa cag 3675 Gly Ala Val Asp Glu Asp Ala Leu Thr Leu Glu Glu Leu Glu Glu Gln 290 295 300 cag agg cgg atc tgg gca gct ctt gag cag gcc gag agc gta aac agc 3723 Gln Arg Arg Ile Trp Ala Ala Leu Glu Gln Ala Glu Ser Val Asn Ser 305 310 315 gac tcc gac gtt cct gtg gac aca cct tta act ggc att tcc gtt gcc 3771 Asp Ser Asp Val Pro Val Asp Thr Pro Leu Thr Gly Asn Ser Val Ala 320 325 330 tca tca cct tgt cca aat gag cta gac ctc cct gtc ccg gag gga aaa 3819 Ser Ser Pro Cys Pro Asn Glu Leu Asp Leu Pro Val Pro Glu Gly Lys 335 340 345 350 aca tct gaa aag cag acg ctg gat gag cct gag gta cca gag att ttt 3867 Thr Ser Glu Lys Gln Thr Leu Asp Glu Pro Glu Val Pro Glu Ile Phe 355 360 365 aca aag aaa tca gaa gct gga cat gcc tcc agt cca gac tct gag gtg 3915 Thr Lys Lys Ser Glu Ala Gly His Ala Ser Ser Pro Asp Ser Glu Val 370 375 380 aca tca ctt tgt cag aag gaa aaa gca gag ttg gct ccg gta aac act 3963 Thr Ser Leu Cys Gln Lys Glu Lys Ala Glu Leu Ala Pro Val Asn Thr 385 390 395 gaa ggt gcc ctt ctt gat aat ggc agt gtc gta cca aac tgt gac atc 4011 Glu Gly Ala Leu Leu Asp Asn Gly Ser Val Val Pro As n Cys Asp Ile 400 405 410 agc aat ggg ggc agc cag aag ctc ttt cct gca gac acc agt cct tca 4059 Ser Asn Gly Gly Ser Gln Lys Leu Phe Pro Ala Asp Thr Ser Pro Ser 415 420 425 430 acg gcc act aaa att cat agc cct ata cct gac atg agc aaa ttt gca 4107 Thr Ala Thr Lys Ile His Ser Pro Ile Pro Asp Met Ser Lys Phe Ala 435 440 445 act gga atc acg cca ttt gaa ttt gag aat atg gca gaa tct act gga 4155 Thr Gly Ile Thr Pro Phe Glu Phe Glu Asn Met Ala Glu Ser Thr Gly 450 455 460 atg tac ctc agg ata aga agc ttg tta aag aac tca ccc cga aac cag 4203 Met Tyr Leu Arg Ile Arg Ser Leu Leu Lys Asn Ser Pro Arg Asn Gln 465 470 475 cag aaa aac aaa aag gcc tct gaa taatggcttg acttagcact gagagctatt 4257 Gln Lys Asn Lys Lys Ala Ser Glu 480 485 taataacttt gttccgttaa ttagtactaa ttaagtggat agatagaatg gttttcctgt 4317 ttgtccctcc catgtttaaa aatctatcca aggttcatgt tccaaagtca agcctatttt 4377 aaagaaagac tgagctcact agttcagtat attttattct cactgacaaa acttgggggg 4437 agatgtgaat atgacctggt ttagagaggg tttgttaagg tttatactat ttttggattg 4 497 tgactatccg tcgagagtga tggtttttat ctgtcttttg tacattgttt tccctttcta 4557 cattttgcta attatcctgt atataagttt aatatatcac tttttaaaag aaaaaattct 4617 accattttaa attcatgttt caactcctac aaccaaatga gaaaaatcag ggatgagcag 4677 ctttatccca tttggggtat ttttgtaagt gatttacatg tgtcaatttt agtaatactt 4737 ttactttttt gtaacttcat ccttcatata tgcttgctat acaggtatgt tcatctttgt 4797 gtacagaggt ttaataaatt agttttcata cacat 4832 <210> 122 <211> 4235 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2272) <400> 122 c gag gag acc aag ccg ctg ctg ggg ggc gac gtg tcg gcc ccc gaa ggc 49 Glu Glu Thr Lys Pro Leu Leu Gly Gly Asp Val Ser Ala Pro Glu Gly 1 5 10 15 acg aag atg ggc gcc gtg ccc tgc cgc cgg gct ctt ctg ctt tgc aac 97 Thr Lys Met Gly Ala Val Pro Cys Arg Arg Ala Leu Leu Leu Cys Asn 20 25 30 ggg atg agg tac aaa ctg ctg cag gag ggc gac att cag gtc tgt gtc T145 Gly Met Arg Leu Leu Gln Glu Gly Asp Ile Gln Val Cys Val 35 40 45 atc cgg cac ccg cgg acc ttt ctc agc aag atc ctc acc tcg aaa ttc 193 Ile Arg His Pro Arg Thr Phe Leu Ser Lys Ile Leu Thr Ser Lys Phe 50 55 60 ctg agg cgc tgg gag ccg cac cac cta acg ctg gcc gac aac agc ctg 241 Leu Arg Arg Trp Glu Pro His His Leu Thr Leu Ala Asp Asn Ser Leu 65 70 75 80 gcg tcc gcc acg cca act ggg tac atg gaa aac tca gt tcc tac agc 289 Ala Ser Ala Thr Pro Thr Gly Tyr Met Glu Asn Ser Val Ser Tyr Ser 85 90 95 gca att gaa gac gtt cag ctg ctg tcc tgg gag aat gcc ccg aag tac 337 Ala Ile Glu Asp Val Gln Leu Leu Ser Trp Glu Asn Ala Pro Lys Tyr 100 105 110 tgt tta cag ctc acg att cct ggg gga act gtc tta ctg cag gct gcc 385 Cys Leu Gln Leu Thr Ile Pro Gly Gly Thr Val Leu Leu Gln Ala Ala 115 120 125 aat agc tac ctg cga gac cag tgg ttc cat tct ctg ca tgg aag aaa 433 Asn Ser Tyr Leu Arg Asp Gln Trp Phe His Ser Leu Gln Trp Lys Lys 130 135 140 aag att tac aaa tat aag aaa gtg ctg agt aac cca agc cgc tgg gaa 481 Lys Ile Tyr Lys Tyr Lys Val Leu Ser Asn Pro Ser Arg Trp Glu 145 150 155 160 gtt gtc ttg aaa gag atc cgg acc ctg gtg gac atg gcc ctg aca tcc 529 Val Val Leu Lys Glu Ile Arg Thr Leu Val Asp Met Ala Leu Thr Ser 165 170 175 ccc ctg cag gat gac tcc atc aac cag gcc cca ctg gaa atc gtc tcg 577 Pro Leu Gln Asp Asp Ser Ile Asn Gln Ala Pro Leu Glu Ile Val Ser 180 185 190 aaa ctg ctc tca gag aac aca aac ttg acc acc cag gag cat gaa aac 625 Lys Leu Leu Ser Glu Asn Thr Asn Leu Thr Thr Gln Glu His Glu Asn 195 200 205 atc att gtg gca atc gct cct ttg ctg gaa aac aac cac cca cca cca 673 Ile Ile Val Ala Ile Ala Pro Leu Leu Glu Asn Asn His Pro Pro Pro 210 215 220 gat ctc tgt gaa ttc ttt tgc aag cac tgc aga gag cgg ccc cgg tcc 721 Asp Leu Cys Glu Phe Phe Cys Lys His Cys Arg Glu Arg Pro Arg Ser 225 230 235 240 atg gtg gtc atc gag ccg ttc acc gtg gtg cag cga atc ctc aag 769 Met Val Val Ile Glu Val Phe Thr Pro Val Val Gln Arg Ile Leu Lys 245 250 255 cat aac atg gac ttt ggg aag tgc ccg cga ctg agg ctg ttt act cag 817 His Asn Met Asp Phe Gly Lys Cys Pro Arg Leu Arg Leu Phe Thr Gln 260 265 270 gag tac atc ctt gcc ttg aac gag ctc aac gcg ggg atg gaa gtg gtg 865 Glu Tyr Ile Leu Ala Leu Asn Glu Leu Asn Ala Gly Met Glu Val ag 275 280 aag ttc att cag agc atg cac ggc ccc aca ggg cac tgc ccc cac 913 Lys Lys Phe Ile Gln Ser Met His Gly Pro Thr Gly His Cys Pro His 290 295 300 ccc cgg gtc ctg ccc aac ctg gtg gcc gtg gc ctg tac 961 Pro Arg Val Leu Pro Asn Leu Val Ala Val Cys Leu Ala Ala Ile Tyr 305 310 315 320 tcc tgc tat gaa gag ttc atc aac agc cgc gac aat tcc cca agc ctg 1009 Ser Cys Tyr Glu Glu Phe Ile Asn Ser ArA sp Asn Ser Pro Ser Leu 325 330 335 aag gaa atc cgg aac ggc tgc cag cag ccg tgc gac cgg aag ccc act 1057 Lys Glu Ile Arg Asn Gly Cys Gln Gln Pro Cys Asp Arg Lys Pro Thr 340 345 350 tta cct ctg cgc ctt ctg cac ccc agc ccg gac ctg gtg tct cag gaa 1105 Leu Pro Leu Arg Leu Leu His Pro Ser Pro Asp Leu Val Ser Gln Glu 355 360 365 gcc acg ctg tct gag gcc cgg ctc aag tcg gtg gtc gtg gcc Acc agt Leu Ser Glu Ala Arg Leu Lys Ser Val Val Val Ala Ser Ser 370 375 380 gag atc cac gtg gag gtg gaa cgc acc agc act gcc aag ccg gcg ctg 1201 Glu Ile His Val Glu Val Glu Arg Thr Ser Thr Ala Lys Pro Ala Leu 385 390 395 400 acg gcc agc gca ggc aac gac agc gag ccc aac ctc atc gac tgc ctc 1249 Thr Ala Ser Ala Gly Asn Asp Ser Glu Pro Asn Leu Ile Asp Cys Leu 405 410 415 atg gtc agc ccc gcc tgc ag cg atc gag ctg ggc ccc cag 1297 Met Val Ser Pro Ala Cys Ser Thr Met Ser Ile Glu Leu Gly Pro Gln 420 425 430 gcc gac cgc acg ctc ggc tgc tac gtg gaa atc ctc aag ctg ctg tca 1345 Ala Asp Arg Thr Le ly Cys Tyr Val Glu Ile Leu Lys Leu Leu Ser 435 440 445 gac tat gat gac tgg aga ccg tct ctg gcc agt ttg ctt caa ccc att 1393 Asp Tyr Asp Asp Trp Arg Pro Ser Leu Ala Ser Leu Leu Gln Pro Ile 450 455 460 cca ttc ccc aaa gaa gct ctc gca cat gag aag ttc acc aag gaa ctg 1441 Pro Phe Pro Lys Glu Ala Leu Ala His Glu Lys Phe Thr Lys Glu Leu 465 470 475 475 480 aag tac gtg att cag agg ttc gcc gaga gac ccc gag gtc cac 1489 Lys Tyr Val Ile Gln Arg Phe Ala Glu Asp Pro Arg Gln Glu Val His 485 490 495 tca tgc ctg ctg agc gtg cgg gcc ggc aaa gat ggc tgg ttc cag ctc 1537 Ser Cys Leu Leu Ser Val Ag Asp Gly Trp Phe Gln Leu 500 505 510 tac agc ccc gga ggg gtg gcc tgc gac gat gac ggg gag ctg ttc gcc 1585 Tyr Ser Pro Gly Gly Val Ala Cys Asp Asp Asp Gly Glu Leu Phe Ala 515 520 525 agc atg gt ctc atg ggc tcc tgt tac aag acc aaa aaa ttc 1633 Ser Met Val His Ile Leu Met Gly Ser Cys Tyr Lys Thr Lys Lys Phe 530 535 540 ctg ctc tcc ctg gca gaa aac aag ctg ggt ccc tgc atg ctc ctg u Leu Ser Leu Ala Glu Asn Lys Leu Gly Pro Cys Met Leu Leu Ala 545 550 555 560 ctg agg ggg aac cag acc atg gtg gag atc ctg tgc ttg atg ctg gaa 1729 Leu Arg Gly Asn Gln Thr Met Val Glu Ile Leu Met Leu Glu 565 570 575 tac aac atc atc gac aac aac gac acc caa ctg cag atc atc tca acc 1777 Tyr Asn Ile Ile Asp Asn Asn Asp Thr Gln Leu Gln Ile Ile Ser Thr 580 585 590 ctg gag agc aca gag ggg ggg cgc atg tac gag cag ctg tgt gac 1825 Leu Glu Ser Thr Asp Val Gly Lys Arg Met Tyr Glu Gln Leu Cys Asp 595 600 605 cgg cag cgg gag ctg aag gag ctg caa agg aaa ggc ggg ccc acc agg 1873 Arg Glu Arg Glu Lys Glu Leu Gln Arg Lys Gly Gly Pro Thr Arg 610 615 620 cta aca ctg ccc tcc aag tcc aca gac gct gac ttg gct cgt ttg ctg 1921 Leu Thr Leu Pro Ser Lys Ser Thr Asp Ala Asp Leu Ala Arg Leu Leu 625 630 640 agc tcc ggc tcc ttc gga aac ctg gag aac ctc agt ttg gcc ttc acc 1969 Ser Ser Gly Ser Phe Gly Asn Leu Glu Asn Leu Ser Leu Ala Phe Thr 645 650 655 aat gta acc agt gcc tgc gcc gag cac ctc atc ctg cct tcg ctc 2017 Asn Val Thr Ser Ala Cys Ala Glu His Leu Ile Lys Leu Pro Ser Leu 660 665 670 aag cag ctg aac ctg tgg tcc act cag ttt gga gac gct ggc ctt cgg 2065 Lys Gln Leu Asn Leu Trp Ser Thr Gln Phe Gly Asp Ala Gly Leu Arg 675 680 685 ctc ctg tcg gaa cac ctc acc atg ctc cag gtg ctg aac ctg tgc gag 2113 Leu Leu Ser Glu His Leu Thr Met Leu Gln Val Leu Asn Leu Cys Glu 690gca acc gac gct ggc ctg ctg gcc ctg agc tcc atg aag agt 2161 Thr Pro Val Thr Asp Ala Gly Leu Leu Ala Leu Ser Ser Met Lys Ser 705 710 715 715 720 ctc tgc agt tta aac atg aac agc acc aag ctc tca gct gac acc tac Leu Cys Ser Leu Asn Met Asn Ser Thr Lys Leu Ser Ala Asp Thr Tyr 725 730 735 gaa gat ctg aag gcc aag ctt ccc aat ttg aag gaa gtg gac gtc cgc 2257 Glu Asp Leu Lys Ala Lys Leu Pro Asn Leu Lys Glu Val Arg 740 745 750 tac acc gaa gcc tgg tgaagctccc agctcaaggc aggaagacgt ttgcaaccgc 2312 Tyr Thr Glu Ala Trp 755 gacaaaataa ctcttgacta acagccgcag agcagccggt cctggggtcc caccctggtg 2372 t gagatagatg gggagtcttt ctgggggcgg aggggggagg gggtggggag 2432 ggggcccaca agcacgccca gcccccgccg aattctttta gcttcgtaat tggaaccttt 2492 gacctgatct aaagtggact ttgtagcaac aagaggagca tcagcgggtc ggggaggggt 2552 ttgggggtgg gctggggggt gggggaccct ttgtggattt tctttgcctt tgtgtttgat 2612 gccgtcgtgt gggaaaagtc aactccgatg ccaccattgc gggccggacg aaggatgctt 2672 tcttcctaga ggctccgagc tgagctgcga actcgccccc cgcccttggg acaagaagac 2732 ccagtcacat cactgcaccc gtcctgtgtc ctcaccattg ctatgcaaag tgattcttgt 2792 tgtacataag atttaaataa tgcacctatt taagacatgt tgacaaattg cgggtctggg 2852 acccgcctct tatttatgaa gtctttgacc gtcccccccg cccgacccca ccgccctccc 2912 gcccccacct ggcgtgtagt actgtataaa ccagtcagct gtcgggttag tggtagtatt 2972 attgttattt ttttaaagga aacaaacaga caacaaaaag aagaaaaaaa aaaagaacct 3032 ccttggaaaa attaattgct ttttcgtaat ggattctcta tgctaatgct ctctcgtctg 3092 tctgtctgtc tgcccactcc cccacccacc actgtgcgtt tctgatttcc aaatgtctcc 3152 aactccctca cgaggtgggg ctcaggctgg aggaggaggg attaagatcc ccttgctcca 3212 ctaaggccca agct ctttct ctcggcacct tttagacttg aatgggaggc tgctaacccg 3272 ccctctccag tccaccccgg taaaagagct gttccccacc cccagggagc tcctgtccct 3332 gtcagccttt gctgtcccct gtccccaacg gagactctgt cacccctggg ctccccctgc 3392 catcgtgtgc ttcacgtggc cccatgcatg cccgcctctc tgcatggtct cttgggaaaa 3452 gagagatgtg tcgcctccgc cagtccgact gccctcccca ccccaccccc gccacccccc 3512 acatgtgacc actgcaacga agacactcct tctgtcccca cctgctccga agacaaacca 3572 acctccgttt cttttataaa cagtcggctt tttcttaata agccctcact gtacagaaca 3632 gcccgttgat ggtttatttg gggtccccct ctccccccag cccttttttc tgttggttta 3692 gcacaaatac ttccctcctc cggcacctcc aaacctaccc cacagtcagt gtacttgttt 3752 tatatatatt taatcttatt caatggaaac catgcttttg tcgttttata ctttgctagg 3812 tagactttat taccccccca ctatgccctc atttttttaa aaaaggaaaa aaaaaagaaa 3872 ctgggttcca gtcttaattc attttccgtg ccaggtttta tttcgtgtgt gtgtgagtgt 3932 gttctgtttt gtgttttgtt ttttgttgtt gttttcagtt gtttggtttt cttttctttc 3992 ccccctccgg tcccatactt cacagcactc tggtgcggga agaagcagaa gcaaaaaaaa 4052 taaaaataaa aaaataaat a aaaataaaaa aaataaaaaa ggaaaaaaaaa aaagaagaaa 4112 caagacatgc cacctttccc ctcgcactgt tgcttttcct gatggttaat actactgtca 4172 cgtagctgtg tacaaagaga tgtgaaatac tttcaggcaa aaataaactg taagtgactc 4232 atc <210> 123 <211> 4126 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3598) <400> 123 g ttc cgc ctg gtg gtg aag aca gcc ctg aag ctg ctg ctc gtc ttt gta 49 Phe Arg Leu Val Val Lys Thr Ala Leu Lys Leu Leu Leu Val Phe Val 1 5 10 15 gag tac tcg gag tcc aac gca cct ctc cta att cag gct gtc act gct 97 Glu Tyr Ser Glu Ser Asn Ala Pro Leu Leu Ile Gln Ala Val Thr Ala 20 25 30 gtt gac acg aaa aga ggg gtc aaa cct tgg tca aat atc atg gaa atc 145 Val Asp Thr Lys Arg Gly Val Lys Pro Trp Ser Asn Ile Met Glu Ile 35 40 45 ctg gag gaa aaa gat gga gtt gat acg gag cta ctg gtt tat gca atg 193 Leu Glu Glu Lys Asp Gly Val Asp Thr Glu Leu Leu Val Tyr Ala Met 50 55 60 act ttg gtg aac aag acg tta tca gga cta cca gac caa gac acc ttc 241 Thr Leu Val Asn Lys Thr Leu Ser Gly Leu Pro Asp Gln Asp Thr Phe 65 70 75 80 tac gac gtc gtg gac tgc ctg gag gag ctg ggc att gct gct gtg tcc 289 Tyr Asp Val Val Asp Cys Leu Glu Glu Leu Gly Ile Ala Ala Val Ser 85 90 95 cag agg cac ttg aac aag aaa ggg act gac ctg gac tta gtg gag caa 337 Gln Arg His Leu Asn Lys Lys Gly Thr Asp Leu Asp Leu Val Glu Gln 100 105 110 ctc aac att tat gag gtg gcg ctc agg cac gag gat ggc gat gag acc 385 Leu Asn Ile Tyr Glu Val Ala Leu Arg His Glu Asp Gly Asp Glu Thr 115 120 125 acg gag cca ccc ccc agt ggg tgc cgg gac cgg agg gcc agc gtg 433 Thr Glu Pro Pro Ser Gly Cys Arg Asp Arg Arg Arg Ala Ser Val 130 135 140 tgt tcc agt ggc gga ggc gag cac cgg ggc ctg gac cgc aga agg agcc 481 Cys Ser Ser Gly Gly Gly Gly Glu His Arg Gly Leu Asp Arg Arg Arg Ser 145 150 155 160 cgc agg cac tcg gtg cag agc atc aag agc acc ctg tcg gcc ccc acc 529 Arg Arg His Ser Val Gln Ser Ile Lys Ser Thr Leu Ser Ala Pro Thr 165 170 175 agt ccc tgc tcc cag tca gct ccc agc ttc aag ccc aac caa gtg cga 577 Ser Pro Cys Ser Gln Ser Ala Pro Ser Phe Lys Pro Asn Gln Val Arg 180 185 190 gat ctg cgt gaa aag tca tca ccg agt ggt ctt ctc aca tca tcc ttc 625 As Leu Arg Glu Lys Ser Ser Pro Ser Gly Leu Leu Thr Ser Ser Phe 195 200 205 agg cag cac caa gag tca ctg gca gca gag aga gag agg cgg cgg cag 673 Arg Gln His Gln Glu Ser Leu Ala Ala Glu Arg Glu Arg Arg Arg Gln 210 215 220 gag aga gaa gaa agg ttg cag aga ata gag cgg gaa gaa aga aac aaa 721 Glu Arg Glu Glu Arg Leu Gln Arg Ile Glu Arg Glu Glu Arg Asn Lys 225 230 235 240 ttc agc cga gat ata tta g gag gag caa agg caa gca aga 769 Phe Ser Arg Asp Tyr Leu Asp Lys Arg Glu Glu Gln Arg Gln Ala Arg 245 250 255 gaa gaa aga tac aaa tac ttg gaa cag ttg gca gct gag gag cac gag 817 Glu Glu Tyr Tyr Leu Glu Gln Leu Ala Ala Glu Glu His Glu 260 265 270 aag gag ctg aga agc cgg agt gtg agc cgg ggc aga gcc gac ctc tcc 865 Lys Glu Leu Arg Ser Arg Ser Val Ser Arg Gly Arg Ala Asp Leu Ser 275 280 285 gac ctg acc tcg cca gca gcc cca gcc tgc ctg gct cct ctg agc 913 Leu Asp Leu Thr Ser Pro Ala Ala Pro Ala Cys Leu Ala Pro Leu Ser 290 295 300 cat agc ccc tca tct tca gac tct caa gag gct ctc acg gt gcc 961 His Ser Pro Ser Ser Ser Asp Ser Gln Glu Ala Leu Thr Val Ser Ala 305 310 315 320 tcc tcc cca gga acc cct cac cat ccc caa gca agt gcc ggg gat cct 1009 Ser Ser Pro Gly Thr Pro His His Pro Gln A la Ser Ala Gly Asp Pro 325 330 335 gaa ccc gaa tca gag gca gaa ccg gaa gca gag gca ggg gcg ggg cag 1057 Glu Pro Glu Ser Glu Ala Glu Pro Glu Ala Glu Ala Gly Ala Gly Gln 340 345 350 gtt gct gat gaa ggc cag gac ata gcc tct gcc cac gag ggt gca 1105 Val Ala Asp Glu Ala Gly Gln Asp Ile Ala Ser Ala His Glu Gly Ala 355 360 365 gag act gaa gtg gag cag gca cta gag caa gag ccg gaa gaa aga gcc 1153 Glu Glu Val Glu Gln Ala Leu Glu Gln Glu Pro Glu Glu Arg Ala 370 375 380 tcc ctc agt gaa aaa gag agg cag aac gag ggg gtg aac gag agg gac 1201 Ser Leu Ser Glu Lys Glu Arg Gln Asn Glu Gly Val Asn Glu Arg Asp 385 390 395 400 aac tgc tct gcc tcc agc gtc tcg tcc tcc agc agc acg ttg gag agg 1249 Asn Cys Ser Ala Ser Ser Val Ser Ser Ser Ser Ser Thr Leu Glu Arg 405 410 415 gag gag aag gag gac aag ctc tcc agg gac agg aca act ggt ttg tgg 1297 Glu Glu Lys Glu Asp Lys Leu Ser Arg Asp Arg Thr Thr Gly Leu Trp 420 425 430 ccc gca ggt gtc cag gat gca ggt gta aat gga cag tgt ggc gac atc 1345 Pro Ala Gly Val Gln A sp Ala Gly Val Asn Gly Gln Cys Gly Asp Ile 435 440 445 ctc acc aac aaa cgg ttc atg ctt gac atg ctg tat gcc cat aac agg 1393 Leu Thr Asn Lys Arg Phe Met Leu Asp Met Leu Tyr Ala His Asn Arg 450 455 460 aag tct ccg gat gat gag gag aag ggg gat ggg gag gct ggg agg acc 1441 Lys Ser Pro Asp Asp Glu Glu Lys Gly Asp Gly Glu Ala Gly Arg Thr 465 470 470 475 480 cag cag gag gca gag gcg gta gcc agc ctt gct acct ata tcc acc 1489 Gln Gln Glu Ala Glu Ala Val Ala Ser Leu Ala Thr Arg Ile Ser Thr 485 490 495 ctg cag gcc aac tct cag acc cag gat gag agt gtc agg agg gtg gat 1537 Leu Gln Ala Asn Ser Gln Thr Gln Asp Glu Ser Val Arg Arg Val Asp 500 505 510 gtc ggc tgt ttg gac aat cgg ggc agt gtg aaa gca ttt gct gag aaa 1585 Val Gly Cys Leu Asp Asn Arg Gly Ser Val Lys Ala Phe Ala Glu Lys 515 520 525 ttc aac agg ggg ctg ggg aga ggt tcc atc tcc cct gat gct gag 1633 Phe Asn Ser Gly Asp Leu Gly Arg Gly Ser Ile Ser Pro Asp Ala Glu 530 535 540 ccc aat gac aag gtc cca gaa aca gcg ccg gtg cag ccg aag aca gag 1681 o Asn Asp Lys Val Pro Glu Thr Ala Pro Val Gln Pro Lys Thr Glu 545 550 555 560 tct gat tac atc tgg gac cag ctc atg gcc aat cca aga gag ctc aga 1729 Ser Asp Tyr Ile Trp Asp Gln Leu Met Ala Asn Pro Arg Glu Leu Arg 565 570 575 atc caa gac atg gat ttc act gac ctg ggg gag gag gat gac att gat 1777 Ile Gln Asp Met Asp Phe Thr Asp Leu Gly Glu Glu Asp Asp Ile Asp 580 585 590 590 gtc cta gat gg gac gtg gac g agg gag gcc cct ggg cca cct ccc 1825 Val Leu Asp Val Asp Leu Gly His Arg Glu Ala Pro Gly Pro Pro 595 600 605 cca ccc cca ccc acc ttt ctg ggt ttg ccg ccc cca ccc cct ccg ccc 1873 Pro Pro Pro Pro Thr Phe Leu Gly Leu Pro Pro Pro Pro Pro Pro Pro 610 615 620 ctg ttg gac agc att cct ccc cct cct gtc cct ggt aat tta ttg gtt 1921 Leu Leu Asp Ser Ile Pro Pro Pro Pro Val Pro Gly Asn Leu Leu Val 625 630 630 635 640 cct cct cct cca gtg ttc aac gct cct cag ggc tta ggg tgg tcc cag 1969 Pro Pro Pro Pro Val Phe Asn Ala Pro Gln Gly Leu Gly Trp Ser Gln 645 650 655 gta ccc agg ggt cag ccc aca ttc act aag aaa aag aag acc atc cgt 2017 Val Pro Arg Gly Gln Pro Thr Phe Thr Lys Lys Lys Lys Thr Ile Arg 660 665 670 ttg ttc tgg aat gaa gtt cgg cct ttt gac tgg cca tgt aaa aac aac 2065 Leu Phe Trp Asn Glu Val Arg Pro Phe Asp Trp Pro Cys Lys Asn Asn 675 680 685 cga cgc tgc aga gaa ttc ctg tgg tca aaa ctg gaa ccc att aag gtg 2113 Arg Arg Cys Arg Glu Phe Leu Trp Ser Lys Leu Glu Pro Ile Lys Val 690 695 700 gac ctg gag cac ctg ttt gag tct aaa tcc aag gaa ctg 2161 Asp Thr Ser Arg Leu Glu His Leu Phe Glu Ser Lys Ser Lys Glu Leu 705 710 710 720 tct gtc tca aag aaa act gct gca gat gga aaa agg caa gag atc att 2209 Ser Val Ser Lys Lys Thr Ala Ala Asp Gly Lys Arg Gln Glu Ile Ile 725 730 735 gtt ctg gat tcc aag agg agt aac gcc atc aat att ggt ctg acg gtg 2257 Val Leu Asp Ser Lys Arg Ser Asn Ala Ile Asn Ile Gly Leu Thr Val 740 745 750 ctg ccc cct cca agg acg att aag atc gcc att ttg aat ttt gat gag 2305 Leu Pro Pro Pro Arg Thr Ile Lys Ile Ala Ile Leu Asn Phe Asp Glu 755 760 765 tat gcc tta aac aaa gaa gga atc gag aaa att cta acg atg att ccc 2353 Tyr Ala Leu Asn Lys Glu Gly Ile Glu Lys Ile Leu Thr Met Ile Pro 770 775 780 acc gat gag gag aag cag aaa atc cag gaa gct cag ctg gcc aac cct 2401 Thr Asp Glu Lys Gln Lys Ile Gln Glu Ala Gln Leu Ala Asn Pro 785 790 795 800 gaa atc ccc ctg ggc agt gca gag cag ttc ctc ctc acc ctg tcc tcc 2449 Glu Ile Pro Leu Gly Ser Ala Glu Gln Phe Leu Leu Thr Leu Ser 810 815 atc agc gag ctc tct gca cga ctt cac ctc tgg gca ttc aaa atg gat 2497 Ile Ser Glu Leu Ser Ala Arg Leu His Leu Trp Ala Phe Lys Met Asp 820 825 830 tat gaa act aca gaa ac gaa gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca gca cca ctg gac ctg aag 2545 Tyr Glu Thr Thr Glu Lys Glu Val Ala Glu Pro Leu Leu Asp Leu Lys 835 840 845 gaa gga ata gac cag ttg gag aac aat aaa acc ttg ggc ttt atc ctg 2593 Glu Gly Ile Asp Gn Len Glu Lys Thr Leu Gly Phe Ile Leu 850 855 860 tct act ctc tta gcc att ggg aac ttt cta aat gga act aat gcc aaa 2641 Ser Thr Leu Leu Ala Ile Gly Asn Phe Leu Asn Gly Thr Asn Ala Lys 865 870 875 875 880 gcg ttt gag tta agc tac ctc gag aag gtt cca gaa gtc aaa gac aca 2689 Ala Phe Glu Leu Ser Tyr Leu Glu Lys Val Pro Glu Val Lys Asp Thr 885 890 895 gt gtg cac aag cag tcg ctt ctc cac cat gtg tgc acc at gaa 2737 Val His Lys Gln Ser Leu Leu His His Val Cys Thr Met Val Val Glu 900 905 910 aac ttc cca gac agc tcc gat ctg tac tcg gag atc ggg gcc atc acc 2785 Asn Phe Pro Asp Ser Ser Asp Leu Tyr Ser Glu Ile Gly Ala Ile Thr 915 920 925 agg tca gcc aag gtt gac ttt gat caa ctt cag gat aat tta tgt cag 2833 Arg Ser Ala Lys Val Asp Phe Asp Gln Leu Gln Asp Asn Leu Cys Gln 930 935 940 atg gag aga aga tgc aaa g tca tgg gat cac ctc aag gca att gca 2881 Met Glu Arg Arg Cys Lys Ala Ser Trp Asp His Leu Lys Ala Ile Ala 945 950 955 960 aaa cat gaa atg aaa cca gtt tta aaa aaa caggg atg tca gag ttc ctg 2929 Lys Met Lys Pro Val Leu Lys Gln Arg Met Ser Glu Phe Leu 965 970 975 aaa gac tgt gca gag cga att ata att tta aag att gtc cat aga agg 2977 Lys Asp Cys Ala Glu Arg Ile Ile Ile Leu Lys Ile Val His Arg A rg 980 985 990 ata atc aac aga ttc cac tcc ttt tta ctc ttt atg ggc cat cca cct 3025 Ile Ile Asn Arg Phe His Ser Phe Leu Leu Phe Met Gly His Pro Pro 995 1000 1005 tat gca att cgg gaa gtg aac ata aacaaa ttc tgc agg att att agt 3073 Tyr Ala Ile Arg Glu Val Asn Ile Asn Lys Phe Cys Arg Ile Ile Ser 1010 1015 1020 gaa ttt gca cta gag tat cgc aca acc agg gaa agg gtt ttg cag cag 3121 Glu Plu Ayr Leu Thr Thr Arg Glu Arg Val Leu Gln Gln 1025 1030 1035 1040 aaa cag aaa cgg gcc aac cac aga gag aga aat aag acc aga ggg aag 3169 Lys Gln Lys Arg Ala Asn His Arg Glu Arg Asn Lys Thr Arg Gly Lys 1045 1050 1055 atg atc acc gat tct ggc aag ttc tcc ggc agt tct ccg gcg ccc cca 3217 Met Ile Thr Asp Ser Gly Lys Phe Ser Gly Ser Ser Pro Ala Pro Pro 1060 1065 1070 agc cag ccg cag ggt ctg agc tat gcg gag gac gc gct gag 3265 Ser Gln Pro Gln Gly Leu Ser Tyr Ala Glu Asp Ala Ala Glu His Glu 1075 1080 1085 aac atg aag gct gtg ctg aaa acc tcg tcc ccc tcc gtg gag gac gcc 3313 Asn Met Lys Ala Val Leu Lys Thr Ser Ser Pro Ser Val Glu Asp Ala 1090 1095 1100 acc ccc gcg ctg ggc gtc cgc aca cgc agc cga gca agc cga gga tcc 3361 Thr Pro Ala Leu Gly Val Arg Thr Arg Ser Arg Ala Ser Arg Gly Ser 1105 1110 1115 1120 act agt tcc tgg act atg gga act gat gac tcg ccc aat gtc aca gat 3409 Thr Ser Ser Trp Thr Met Gly Thr Asp Asp Ser Pro Asn Val Thr Asp 1125 1130 1135 gat gca gct gat gag atc atg gac cgc atc gtc aag tca gcc acc caa 3457 Asp Ala Ala Asp Glu Ile Met Asp Arg Ile Val Lys Ser Ala Thr Gln 1140 1145 1150 gtg ccc agt cag cga gtg gtg ccg agg gag agg aaa cga tcc cgg gcc 3505 Val Pro Ser Gln Arg Val Val Pro Arg Glu Arg Lys Arg Ser Arg Ala 1155 1160 1165 aac cgg aaa tct ttg cga aga acc ctg aag agc ggc ctg acc cca gaa 3553 Asn Arg Lys Ser Leu Arg Arg Thr Leu Lys Ser Gly Leu Thr Pro Glu 1170 1175 1180 gaa gcc gg gcc g ttg gtt ggc acc tcg gag ttg cag ctg 3598 Glu Ala Arg Ala Leu Gly Leu Val Gly Thr Ser Glu Leu Gln Leu 1185 1190 1195 tgacactcat aggttactcc caggagtgtg ctgagcagaa ggcaagctct tgc tggatga 3658 aacccctcca ggtggggttg gggagacttg atattcacat ccaacagttt gaaaagggag 3718 agctcaattc ccagcgtcac cccatggctt gtgttgcctg ctacgcattg acttggatct 3778 ccaggagtcc cctgcacata ccttctccat cgtgtcagct gtgtttctct tgattccgtg 3838 acacccggtt tattagttca aaagtgtgac accttttctg ggcaaggaac agccccttta 3898 aggagcaaat cacttctgtc acagttatta tggtaatatg aggcaatctg attagcttca 3958 cagactgagt ctccacaaca ccaaaatatc cagatgtaaa ccccaaactt gtacacaaaa 4018 gaaagcacag attgtttacc tgttgtggat tttagatgta acaaatgttt atacaaatac 4078 atacatgtac accatgtttc aaatactaaa taaatagagt ttaatgcc 4126 <210> 124 <211> 3908 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (83) .. (1459) <400> 124 aacttgtgtt aaccctcgca catctctggg ccaatttttg cttgtaagtc tttccggaga 60 cccctggaat ttaaatcatt ag cac cgc gcc ctt ccc cga aga gtc ttc gaa 112 His Arg Ala Leu Pro Arg Arg Val g agg aaa atg gca 160 Gly Leu Pro Leu Phe Gly Gly Ala Val Leu Ala Arg Arg Lys Met Ala 15 20 25 gct ccc gag cag ccg ctt gcg ata tca agg gga tgc acg agc tcc tcc 208 Ala Pro Glu Gln Pro Leu Ala Ile Ser Arg Gly Cys Thr Ser Ser Ser 30 35 40 tcg ctt tcc ccg cct cgg ggc gac cga acc ctt ctg gtc agg cac ctg 256 Ser Leu Ser Pro Pro Arg Gly Asp Arg Thr Leu Leu Val Arg His Leu 45 50 55 ccg gct gag ctt act gct gag gag aaa gag gac ttg ctg aag tac ttc 304 Pro Ala Glu Leu Thr Ala Glu Glu Lys Glu Asp Leu Leu Lys Tyr Phe 60 65 70 ggg gct cag tct gtg cgg gtc ctg tca gat aag ggg cga ctg aaa cat 352 Ala Gln Ser Val Arg Val Leu Ser Asp Lys Gly Arg Leu Lys His 75 80 85 90 aca gct ttt gcc aca ttc cct aat gaa aaa gca gct ata aag gca ttg 400 Thr Ala Phe Ala Thr Phe Pro Asn Glu Lys Ala Ala Ile Lys Ala Leu 95 100 105 aca aga ctc cat caa ctg aaa ctt tta ggt cat act tta gtc gtt gaa 448 Thr Arg Leu His Gln Leu Lys Leu Leu Gly His Thr Leu Val Val Glu 110 115 120 ttt gca aaa gag caa gat cga gtt cac tcc cca tgt ccc act tca ggt 496 Phe Ala Lys Glu Gln Asp Arg Val His Ser Pro Cys Pro Thr Ser Gly 125 130 135 tct gaa aaa aaa aaa agg tct gat gac cct gtc gaa gat gat aaa gaa 544 Ser Glu Lys Lys Lys Arg Ser Asp Asp Pro Val Glu Asp Asp Lys Glu 140 145 150 aaa aaa gaa ctt ggt tat tta aca gta gaa aat gga att gca cca aac 592 Lys Lys Glu Leu Gly Tyr Leu Thr Val Glu Asn Gly Ile Ala Pro Asn 155 160 165 170 cat ggg ctg act ttt cct tta aat tca tgc ctc aag tat atg tac cca 640 His Gly Leu Thr Phe Pro Leu Asn Ser Cys Leu Lys Tyr Met Tyr Pro 175 180 185 cca cct tcc agc aca atc cta gca aac att gta aat gcc ttg gca agc 688 Pro Pro Ser Ser Thr Ile Leu Ala Asn Ile Val Asn Ala Leu Ala Ser 190 195 200 gtg cct aag ttc tat gta cag gtc ctt cat ctt atg aat aaa atg aat 736 Val Pro Lys Phe T yr Val Gln Val Leu His Leu Met Asn Lys Met Asn 205 210 215 ttg ccc aca cct ttt gga cca att act gcg cga cct ccc atg tat gaa 784 Leu Pro Thr Pro Phe Gly Pro Ile Thr Ala Arg Pro Pro Met Tyr Glu 220 225 230 gac tat atg cca ttg cat gca cct ctt cca ccc aca tct cct cag cca 832 Asp Tyr Met Pro Leu His Ala Pro Leu Pro Pro Thr Ser Pro Gln Pro 235 240 245 250 cct gag gaa cct cct ttg cca gac gag gat gag gaa tta tct agt gaa 880 Pro Glu Glu Pro Pro Leu Pro Asp Glu Asp Glu Glu Leu Ser Ser Glu 255 260 265 gaa tca gaa tat gaa agc act gat gat gag gac cga cag aga atg aac 928 Glu Ser Glu Tyr Glu Ser Thr Asp Asp Glu Asp Arg Gln Arg Met Asn 270 275 280 aaa tta atg gaa cta gca aat ctt cag ccc aaa aga cct aaa aca ata 976 Lys Leu Met Glu Leu Ala Asn Leu Gln Pro Lys Arg Pro Lys Thr Ile 285 290 290 295 aag cag cgc gtg aga aaa aag aga aaa ata aag gat atg ttg aat 1024 Lys Gln Arg His Val Arg Lys Lys Arg Lys Ile Lys Asp Met Leu Asn 300 305 310 aca cct ttg tgt cct tca cac agc agt tta cat cca gtg ctg ttac 107 r Pro Leu Cys Pro Ser His Ser Ser Leu His Pro Val Leu Leu Pro 315 320 325 330 tca gat gta ttt gac caa cca caa cct gta ggt aac aaa aga att gaa 1120 Ser Asp Val Phe Asp Gln Pro Gln Pro Val Gly Asn Lys Arg Ile Glu 335 340 345 ttc cat ata tct acc gac atg cca gct gca ttt aag aaa gat tta gaa 1168 Phe His Ile Ser Thr Asp Met Pro Ala Ala Pla Lys Lys Asp Leu Glu 350 355 360 aag gaa caa aat tgt gag gaa aaa aat cat gat tta cct gct act gaa 1216 Lys Glu Gln Asn Cys Glu Glu Lys Asn His Asp Leu Pro Ala Thr Glu 365 370 375 gtt gat gca tcc aat ata gga ttt gga aaa atc ttc ccc aaa cct aat 1264 Val Asp Ala Ser Asn Ile Gly Phe Gly Lys Ile Phe Pro Lys Pro Asn 380 385 390 ttg gac atc aca gag gag att aaa gaa gac tct gat gaa atg cct tca 1312 Leu Asp Ile Thr Glu Glu Ile Lys Glu Asp Ser Asp Glu Met Pro Ser 395 400 405 410 gaa tgt att tct aga agg gaa ttg gaa aag ggc aga att tct aga gaa 1360 Glu Cys Ile Ser Arg Arg Glu Leu Glu Lys Gly Arg Ile Ser Arg Glu 415 420 425 gaa atg gaa aca ctt tca gtt ttc aga ccg ggt gaa cca 1408 Glu Met Glu Thr Leu Ser Val Phe Arg Ser Tyr Glu Pro Gly Glu Pro 430 435 440 aac tgt aga att tat gta aag aat tta gct aaa cat gtt caa gaa aag 1456 Asn Cys Arg Ile Tyr Val Lys Asn Leu Ala Lys His Val Gln Glu Lys 445 450 455 ggc taagtggctg aaacaacaga gatgtgttgt ctcacagttc tggaggcaaa 1509 Gly ctgaagtcaa aagtgtggca ggattggttc attctgaggg ctttgagtga aggatctgtt 1569 ctgtgcctct cccatagctt ctgctggtat gcagaagctg gcgaactttc accttccttg 1629 gcttgtggaa gcatcaccac aatttctgcc tttgtacata gcatactccc tttgacctta 1689 aatatatttt tggaagatat gttgactttt catcagaaac acagcggatc atgtttgata 1749 tacgtttgat gaaagaaggt cgtatgaaag gacaagcttt cattggactt cctaatgaaa 1809 aagcagcagc aaaagcctta aaggaagcta atggatatgt gctttttgga aaacccatgg 1869 tggttcagtt tgctcgatct gctagaccaa aacaagatcc taaggaagga aaaagaaagt 1929 gttaaaaatt aataaagaag cattcctgcg taaatactgc tgtaatactg tcatgcaaag 1989 tgtatccttt cttgtcgtat cctttttggg gcagtgtttt tttgtttttt tcctagaaat 2049 gtttgtcctt cccccacctg ttgatccagg ttaaggaata cttttt taca ctttattcaa 2109 atgaaatatt tctaaaatta tttgtataga ctgaacagat cttttatgtg tttttagatt 2169 tgttgttgaa ttttctgtgc tgtcctttat ataatttttt gagggaaagt tagtgaatca 2229 ggtcaactta cttagagaat gtgttcattt actttaaccc agaatacagt cttgtttctt 2289 ctatttgtat gtttcctaaa cctaattcaa taacatatgc tttctgttgt gtaatatatc 2349 tggtttaggt atttataatg tgtttaaaat ttgggcaaag gaaatgtttt tcttttaaaa 2409 agtacttaca ttgaaaatta agatgtctgg attactatgt aaattctaga gagtagcaga 2469 cctctcatct gaagtcttag tgaatctctt ttgacataga tagcaataga agtatctttc 2529 ttctttcccc tttctttttc taaacaagag aagaaaagcg taatagaggg gagaacacat 2589 aatgcccact aagggtagtg cattaaggaa aaacagtctt ggcaggtata taggaatagt 2649 ggtttccaga ctggttgatg accgtaatca ccaagaacag tggttctcag tcttggctgc 2709 acattgcagt gatctggaac ttaaatacta attctaaaag ggtgcagtgg ctcatacctg 2769 taatcccagc actttgcaag tccgagatgg gagaatcact tgagcccagg agtttgagac 2829 cagcctgggc aatgtaggga gaccctgtcc ctacaaaaaa tacaaaaatt agccaagtgt 2889 ggtggcttgc acctctggtc tcagctactt gggatgctaa ggcaggagga t tacttgagc 2949 cccagaggtt gaggttgcag tgaaccatga tcacaccact gcattctagc ctgggtgaca 3009 gagtgagacc ctctccctcc taaaaaaatc cttaagaaat atattgatgc ttggttcctt 3069 tggtcagaat tttgatttaa ggtgttggga gtgtagcaca gatgttggaa taaacctctc 3129 aaactgattt taatatacaa acaaggtcga gaaccaccaa ggaagagttt ttatgcataa 3189 agattcctgt actctaccct agaactaata catctgaatc tctgggaatg gagtataaca 3249 atcagatttg aaaaggtttc tttagtaatt ttaaggactg accagtttag acactgcttt 3309 gttagagtaa aatgattagg tacctagtat caacctagcc atccaacctt atattaataa 3369 ctaggaaaat aaagggttgg agcctctgtg tttctttgtt gaaaaatctg ctactattat 3429 tagatctgtg aaaacaattg aaaattcggt tattatcacc ttaaaagtac aaaacctata 3489 gattttgaaa atgtaattat ttttctgtag gcatagttaa aaagattttg taaatgttat 3549 aaatcagttt ctttataagc ggtttattta gataaatttt gttatactga catgattcac 3609 taattttcta aatataaatg gttcagctct tagttatttt taaactaatg acctgtgtta 3669 tacttcctat ttttaatggg cttttatgat gttttaggtt tttttgaatc ccgtgtcctt 3729 caagtgtttt ctaactttga gaggaagaaa ttgaccacct ggactatgga actgtg cgta 3789 acagctttga aagtgtattt aaaaattaaa tctatatgcc tttaaatcag tgaattggaa 3849 acatattaca tgtattttaa tgattttcct caaatataat aaattgtttc ctttccaat 3908 <210> 125 <211> 4526 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1103) <400> 125 aa tac agt gac agc aca ggt cac agt aag gcc aaa aat gtg cat act 47 Tyr Ser Asp Ser Thr Gly His Ser Lys Ala Lys Asn Val His Thr 1 5 10 15 cac aga gtt aga gag agg gat ggt ggg acc agt tac tct cca caa gaa 95 His Arg Val Arg Glu Arg Asp Gly Gly Thr Ser Tyr Ser Pro Gln Glu 20 25 30 aat tca cac aac cac agt gct ctt cat agt tca aat tca cat tct tct 143 Asn Ser His Asn His Ser Ala Leu His Ser Ser Asn Ser His Ser Ser 35 40 45 aat cca agc aat aac cca agc aaa act tca gat gca cct tat gat tct 191 Asn Pro Ser Asn Asn Pro Ser Lys Thr Ser Asp Ala Pro Tyr Asp Ser 50 55 60 gca gat gac tgg tct gag cat att agc tct tct ggg aaa aag tac tac 239 Ala Asp Asp Trp Ser Glu His Ile Ser Ser Ser Gly Lys Lys Tyr Tyr 65 70 75 tac aat tgt cga aca gaa gtt tca caa tgg gaa aaa cca aaa gag tgg 287 Tyr Asn Cys Arg Thr Glu Val Ser Gln Trp Glu Lys Pro Lys Glu Trp 80 85 90 95 ctt gaa aga gaa cag aga caa aaa gaa gca aac aag atg gca gtc aac 335 Leu Glu Arg Glu Gln Arg Gln Lys Glu Ala Asn Lys Met Ala Val Asn 100 105 110 ag c ttc cca aaa gat agg gat tac aga aga gag gtg atg caa gca aca 383 Ser Phe Pro Lys Asp Arg Asp Tyr Arg Arg Glu Val Met Gln Ala Thr 115 120 125 gcc act agt ggg ttt gcc agt gga atg gaa gac aag cat tcc agt gat 431 Ala Thr Ser Gly Phe Ala Ser Gly Met Glu Asp Lys His Ser Ser Asp 130 135 140 gcc agt agt ttg ctc cca cag aat att ttg tct caa aca agc aga cac 479 Ala Ser Ser Leu Leu Pro Gln Asn Ile Leu Ser Gln Thr Ser Arg His 145 150 155 aat gac aga gac tac aga ctg cca aga gca gag act cac agt agt tct 527 Asn Asp Arg Asp Tyr Arg Leu Pro Arg Ala Glu Thr His Ser Ser Ser 160 160 165 170 175 acg cca gta cag cac ccc atc aaa cca gtg gtt cat cca act gct acc 575 Thr Pro Val Gln His Pro Ile Lys Pro Val Val His Pro Thr Ala Thr 180 185 190 cca agc act gtt cct tct agt cca ttt acg cta cag tct gat cac cag 623 Pro Ser Thr Val Pro Ser Ser Pro Phe Thr Leu Gln Ser Asp His Gln 195 200 205 cca aag aaa tca ttt gat gct aat gga gca tct act tta tca aaa ctg 671 Pro Lys Lys Ser Phe Asp Ala Asn Gly Ala Ser Thr Leu Ser Lys Leu twenty one 0 215 220 cct aca ccc aca tct tct gtc cct gca cag aaa aca gaa aga aaa gaa 719 Pro Thr Pro Thr Ser Ser Val Pro Ala Gln Lys Thr Glu Arg Lys Glu 225 230 235 tct aca tca gga gac aaa ccc gta tca cat tct tgc aca act cct tcc 767 Ser Thr Ser Gly Asp Lys Pro Val Ser His Ser Cys Thr Thr Pro Ser 240 245 250 255 acg tct tct gcc tct gga ctg aac ccc aca tct gca cct cca aca tct 815 Thr Ser Ser Ala Ser Gly Leu Asn Pro Thr Ser Ala Pro Pro Thr Ser 260 265 270 gct tca gcg gtc cct gtt tct cct gtt cca cag tcg cca ata cct ccc 863 Ala Ser Ala Val Pro Val Ser Pro Val Pro Gln Ser Pro Ile Pro Pro 275 280 285 tta ctt cag gac cca aat ctt ctt aga caa ttg ctt cct gct ttg caa 911 Leu Leu Gln Asp Pro Asn Leu Leu Arg Gln Leu Leu Pro Ala Leu Gln 290 295 300 gcc acg ctg cag ctt aat aat tct aat gtg gac ata tat aaa 959 Ala Thr Leu Gln Leu Asn Asn Ser Asn Val Asp Ile Ser Lys Ile Asn 305 310 315 gaa gca gct gtg aca caa gcc tca ctg cag tct ata att cat aag ttt 1007 Glu Ala Ala Val Thr Gln Ala Ser Leu Gln Ser Ile IleHis Lys Phe 320 325 330 335 ctt act gct gga cca tct gct ttc aac ata acg tct ctg att tct caa 1055 Leu Thr Ala Gly Pro Ser Ala Phe Asn Ile Thr Ser Leu Ile Ser Gln 340 345 350 350 gct gct cag ctc tct aca caa ggt att ctt act cat ctt aga tat ctc 1103 Ala Ala Gln Leu Ser Thr Gln Gly Ile Leu Thr His Leu Arg Tyr Leu 355 360 365 tagaatggca tcttgatttt gttttggaat taatagccct tttttgtatt tagttttttc 1163 tttcattttt ttttttagtt ttttaagaga ttagctacaa taattttgtt ttttttgtaa 1223 cactggcata tacagtagta tttttatttc ctttcttttt agatgaagca agctttgaca 1283 tttgtcttaa ggtattgcca tcaaatctgt aattatttaa gacagtattt aattcagact 1343 ttgttattaa tgagtttttt tatgccaaag ctgaaagtaa actatgatgt gccatatatc 1403 tttgtgaaac attgcatgta tttgaagagt tgaagtttgg ttcagattga cgttagatgt 1463 tttttgactg gataatatgg aaatgctcat tttctgcctt gaattagata tccctcttca 1523 tgaaggtatc caaatggaga gagatacaca taggagcaaa tgggaagtga aagggtcact 1583 ttgtcagaaa gctgataaac agcaggaatg ccttgtctgg aatggaagta taatggtgca 1643 aagactcttg caaccctctg gctagcctca tgagcaggag actgcgtggg atacctgggc 1703 ctaaatgtag aataagaaag aagaaataag gatggtgagg aggccttcca tgtgagatta 1763 ggttcaggcc tagcttcctg ttccagccac ataaaggaga gtgggccaca ctgggtgtgc 1823 ttacctctga acacacagct cacttagtca gtgtggccca gtgagaaggt cagattctga 1883 tttattccaa taagtgttct ctgggtaata tgggggtggg ggggtttaga gtaatacaaa 1943 tatctttgcc acatatatta caaaggactt tagttttttg ttttgttttg tttttcttta 2003 aaattaattg cttccctctt ttacagccca gccatctaat cagtctccga tgtctttaac 2063 atctgatgcg tcatccccaa gatcatatgt ttctccaaga ataagcacac ctcaaactaa 2123 cacagtccct atcaaacctt tgatcagtac tcctcctgtt tcatcacagc caaaggttag 2183 tactccagta gttaagcaag gaccagtgtc acagtcagcc acacagcagc ctgtaactgc 2243 tgacaagcag caaggtcatg aacctgtctc tcctcgaagt cttcagcgct caaggtaggt 2303 tgatattgta tattgagacc acattgtttt atttaatgat ggtacactgc attgtttgaa 2363 tattatatct gtaaaataga acttaacctt taaactccat gaatacccta aagtaggctt 2423 acatgttgta aaatttacaa agacaaacct gtatacaaga ggtaggttat tgtctctagt 2483 agtgaagccc gggttatttt gaagaaagtg gctctttaaa attt tacaca gtggaatatg 2543 acggggctaa agatttgtga tacttgtacc agaaaggcac acgattttac aatatttgtt 2603 ggaattacct tactttttaa cctcctcata gcagttttgg tttgagtata ttgatgaaag 2663 ccaaagtctg gtatctaaaa cttgggccaa tgtttcccaa ctggtatatg tcaggctttc 2723 ccaatagctt aactgtgacc ctatacggat ggctttttag atagttctat actgctgtat 2783 tgtgttagca cttttctttg ttcattaaca acacaacttt aaatgacatt tgttgaatga 2843 atggttttca tttgattgat tttcctgttt tttatttcat gctatgaggt agcaaaataa 2903 ttcaactgtt gtttttattg ttgttttcta aacaagcatt tcagaactta cacctccaaa 2963 tgagagttgt tcccttcaaa ataatgacct tgggaagctg tctacttact ccagcaatgt 3023 tgccattgct ctgaacattt ttgggaaatt cttcttttaa attgttttta gaggctgcag 3083 tattatttta aatatcctca gtgatgaaaa ctcttcatcc tttgggagat ttagtttttg 3143 gaaataactg aaattcattc agagccaagt ctggtgaagc aggtaggaga tcaacttggg 3203 tgattaaatt ttttggttct caccaccata tccccaaccc tggcccaaac cattcagttt 3263 taaaagaaga taaagaatct cagagtgtta tttttttggt tttgttttgc cactgtgctt 3323 gttcagtgct atccaataaa atgtctgtat tttgcttcac attatttca c cctctgattc 3383 agcagttctg acgttgaaca aaggcaatat atattttccc cttatctaga tgtgtatgag 3443 cagtcttcag atgtgcatct acagctgtta aaatgtgact ttttttagtt atattattag 3503 tgtttgtggt acacaaagtt aacaggttct gctctcagat ttggagagta gtttacattt 3563 gactctgaca gtagtgttaa aagggttttt tccccctaaa gtgttttgag gaatcatata 3623 ctttggatta ttaattctct ttatttgaca ttaaaataac aaatttttct taggaatttg 3683 gatatcttta agttaataaa aggtattaac atgcagtttc taggataagg atacccagaa 3743 actactttta aacatactac acattcaatt ctgttttcta gtagccagag aagtccatca 3803 cctggtccca atcatacttc taatagtagt aatgcatcaa atgcaacagt tgtaccacag 3863 aattcttctg cccgatccac gtgttcatta acgcctgcac tagcagcaca cttcagtgaa 3923 aatctcataa aacacgttca aggatggcct gcagatcatg cagagaagca ggcatcaaga 3983 ttacgcgaag aagcgcataa catgggaact attcacatgt ccgaaatttg tactgaatta 4043 aaaaatttaa gatctttagt ccgagtatgt gaaattcaag caactttgcg agagcaaagg 4103 atactatttt tgagacaaca aattaaggaa cttgaaaagc taaaaaatca gaattccttc 4163 atggtgtgaa gatgtgaata attgcacatg gttttgagaa caggaactgt aaat ctgttg 4223 cccaatctta acatttttga gctgcattta agtagacttt ggaccgttaa gctgggcaaa 4283 ggaaatgaca aggggacggg gtctgtgaga gtcaattcag gggaaagata caagattgat 4343 ttgtaaaacc cttgaaatgt agatttcttg tagatgtatc cttcacgttg taaatatgtt 4403 ttgtagagtg aagccatggg aagccatgtg taacagagct tagacatcca aaactaatca 4463 atgctgaggt ggctaaatac ctagcctttt acatgtaaac ctgtctgcaa aattagcttt 4523 ttt 4526 <210> 126 <211> 4425 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1348) <400> 126 g agc agg ctg ttt agc aag gct ctg aaa gga gac cac cgc tgt ggg gag 49 Ser Arg Leu Phe Ser Lys Ala Leu Lys Gly Asp His Arg Cys Gly Glu 1 5 10 15 acc gag acc ccc aag agc tgc agc gaa gtt gca gga tgc aag gca gcc 97 Thr Glu Thr Pro Lys Ser Cys Ser Glu Val Ala Gly Cys Lys Ala Ala 20 25 30 atg agg cac cag ggg aag atc ccc gag gag ctt tca cta gat gac aga 145 Met Arg His Gln Gly Lys Ile Pro Glu Glu Leu Ser Leu Asp Asp Arg 35 40 45 gcg agg acc cag aag aag tgg ggg agg ggg aaa tgg gag cca gaa ccc 193 Ala Arg Thr Gln Lys Lys Lys Trp Gly Arg Gly Lys Trp Glu Pro Glu Pro 50 55 60 agt agc aag ccc ccc agg gaa gcc act ctg gaa gag agg cac gca agg 241 Ser Ser Lys Pro Pro Arg Glu Ala Thr Leu Glu Glu Arg His Ala Arg 65 70 75 80 gga gag aag cat ctt ggg gtg gag att gaa aag acc tcg ggt gaa att 289 Gly Glu Lys His Leu Gly Val Glu Ile Glu Lys Thr Ser Gly Glu Ile 85 90 95 atc aga tgc gag aag tgc aag aga gag agg gag ctt cag cag agc ctg 337 Ile Arg Cys Glu Lys Cys Lys Arg Glu Arg Glu Leu Gln Gln Ser Leu 100 105 110 gag cgt gag agg ctt tct ctg ggg acc agt gag ctg gat atg ggg aag 385 Glu Arg Glu Arg Leu Ser Leu Gly Thr Ser Glu Leu Asp Met Gly Lys 115 120 125 ggc cca atg tat gat gtg gag aag ctg gtg agg accaga agc tgc agg 433 Gly Pro Met Tyr Asp Val Glu Lys Leu Val Arg Thr Arg Ser Cys Arg 130 135 140 agg tct ccc gag gca aat cct gca agt ggg gag gaa ggg tgg aag ggt 481 Arg Ser Pro Glu Ala Asn Pro Ala Ser Gly Glu Glu Gly Trp Lys Gly 145 150 155 160 gac agc cac agg agc agc ccc agg aat ccc act caa gag ctg agg aga 529 Asp Ser His Arg Ser Ser Pro Arg Asn Pro Thr Gln Glu Leu Arg Arg 165 170 175 ccc agc aag agc atg gac aag aaa gag gac aga ggc cca gag gat caa 577 Pro Ser Lys Ser Met Asp Lys Lys Glu Asp Arg Gly Pro Glu Asp Gln 180 185 190 gaa agc cat gct cag gga gca gcc aag gcc aag aag gac ctt gtg gaa 625 Glu Ser His Ala Gln Gly Ala Ala Lys Ala Lys Lys Asp Leu Val Glu 195 200 205 gtt ctt cct gtc aca gag gag ggg ctg agg gag gtg aag aag aag gac acc 673 Val Leu Pro Val Thr Glu Glu Gly Leu Arg Glu Val Lys Lys Asp Thr 210 215 220 agg ccc atg agc agg agc aaa cat ggt ggc tgg ctc ctg aga gag cac 721 Arg Pro Met Ser Arg Ser Lys His Gly Gly Trp Leu Leu Arg Glu His 225 230 235 240 cag gcg ggc ttt gag aag ctc cgc agg acc cga gga gaa gag aag gag 769 Gln Ala Gly Phe Glu Lys Leu Arg Arg Thr Arg Gly Glu Glu Lys Glu 245 250 255 gca gag aag gag aaa aag cca tgt atg tct gga ggc aga agg atg act 817 Ala Glu Lys Glu Lys Lys Pro Cys Met Ser Gly Gly Arg Arg Met Thr 260 265 270 ctc aga gat gac caa cct gca aag cta gaa aag gag ccc aag acg agg 865 Leu Arg Asp Asp Gln Pro Ala Lys Leu Glu Lys Glu Pro Lys Thr Arg 275 280 285 cca gaa gag aac aag cca gag cgg ccc agc ggt cgg aag cca cgg ccc 913 Pro Glu Glu Asn Lys Pro Glu Arg Pro Ser Gly Arg Lys Pro Arg Pro 290 295 300 atg ggc atc att gcc gcc aat gtg gaa aag cat tat gag act ggc cgg 961 Met Gly Ile Ile Ala Ala Asn Val Glu Lys His Tyr Glu Thr Gly Arg 305 310 315 320 gtc att ggg gat ggg aac ttt gct gtc gtg aag gag tgc aga cac cgc 1009 Val Ile Gly Asp Gly Asn Phe Ala Val Ly s Glu Cys Arg His Arg 325 330 335 gag acc agg cag gcc tat gcg atg aag atc att gac aag tcc aga ctc 1057 Glu Thr Arg Gln Ala Tyr Ala Met Lys Ile Ile Asp Lys Ser Arg Leu 340 345 350 350 aag ggc aag gag gac atg gtg gac agt gag atc ttg atc atc cag agc 1105 Lys Gly Lys Glu Asp Met Val Asp Ser Glu Ile Leu Ile Ile Gln Ser 355 360 365 ctc tct cac ccc aac atc gtg aaa ttg cat gaa gtc tac 153 aa aca gac His Pro Asn Ile Val Lys Leu His Glu Val Tyr Glu Thr Asp 370 375 380 atg gaa atc tac ctg atc ctg gag tac gtg cag gga gga gac ctt ttt 1201 Met Glu Ile Tyr Leu Ile Leu Glu Tyr Val Gln Gly Gly Asp Leu Phe 385 390 395 400 gac gcc atc ata gaa agt gtg aag ttc ccg gag ccc gat gct gcc ctc 1249 Asp Ala Ile Ile Glu Ser Val Lys Phe Pro Glu Pro Asp Ala Ala Leu 405 410 415 atg atc atg gac tta tcc aaa gcc aaa gcc cac atg cac gac aag agc 1297 Met Ile Met Asp Leu Cys Lys Ala Leu Val His Met His Asp Lys Ser 420 425 430 att gtc cac cgg gac ctc aag ccg gaa aac ctt ttg ctg cta aag atc 1345 Ile Val His Arg Asp Le u Lys Pro Glu Asn Leu Leu Leu Leu Lys Ile 435 440 445 tgg tgagccggtt gctggtggta gaccccaaaa agcgctacac agctcatcag 1398 Trp gttcttcagc acccctggat cgaaacagct ggcaagacca atacagtgaa acgacagaag 1458 caggtgtccc ccagcagcga gggtcacttc cggagccagc acaagagggt tgtggagcag 1518 gtatcatagt caccaccttg ggaatctgtc cagcccccag ttctgctcaa ggacagagaa 1578 aaggatagaa gtttgagaga aaaacaatga aagaggcttc ttcacataat tggtgaatca 1638 gagggagaga cactgagtat attttaaagc atattaaaaa aattaagtca atgttaaatg 1698 tcacaacata tttttagatt tgtatattta aagcctttaa tacatttttg gggggtaagc 1758 attgtcatca gtgaggaatt ttggtaataa tgatgtgttt tgcttcccct ttgtaaccaa 1818 gtttattctg tactacagga gtggtgctta ccagggtcta aactccccct gtgagattaa 1878 taaggtgcat tgtggtcttt ctgtgttaat aaaatgtgct ctgaataaca gaagtgggcc 1938 tgtattctga ttacttcttt gtgctggtga tgacagccag ggaatgaatt atagttcagg 1998 catatctcct gaagctgata tgactacata tagatgtgaa ggacacttga ttagttgaca 2058 agacctgttt atttaggatg cactaatctt ggtctcttgc atttcagtct taccaaaaat 2118 cagttttggt gcagtctgag acat ggaaag aaaaaaaaca aaccattgaa tcattcttgc 2178 tcctgcaata ccgttatact gcttttcagc cccaattatc cctgagcctg agtcatttct 2238 atgtgaagtc aggcgctcag gctgtgaccg tgttaacatt ttcagatcac gagggagcca 2298 tttagtacat tcatatgtca gaaatgcagt aaatggatta cactggggct ccaaggagct 2358 cagagttcaa gcacaatcct acctgcaggg catacaccca ggacacattc cagatttctg 2418 tgctgaaata ttggtctttg cagatgattc tgggagtctg tgtgagctga cagcaagaca 2478 tatcctaata tttcccaaat tgaccttcct agattatgaa tgacctggtt agtaggccac 2538 aaaatctagt caagagtgtg gctttttcac gtctaccttc cctaacagtt ttggagccat 2598 ctgggcggag gcgtgtgtta gttaggaaaa ccggaacagt actagagaat tcaacataag 2658 gaattgctta atcaggtttt ggaaaatgga agaagcacaa aggaggctct ggtataattt 2718 agagatagta actgcaggaa gtggctcctg ttctttggag aaccaaggga agaagttggg 2778 gttattagaa cctattgaag gagaaatttc ttgtagtgga cactgtagta tgccactcag 2838 gtcctccaag actgaaggga ataagctcct tggggtgctg ctggatgatg gctctcagct 2898 ttcagccctc tacaggaatt accctccact ggaagagaca cctttcagct ccctcctgaa 2958 gcaggctata tcaaatgact agtccctgt a gggtatggtg gctcagctcc tttgtcccaa 3018 acagggacaa tactgaaggg ccatccaact acggacctgc ccatgggggt tggctgaact 3078 gttggttgag actgcatcat agcccacttt ctcccttgcc caatcctgct tctttccttt 3138 cccttccaga ggtaatgatc ctgagaccac tccctaataa gccttttgga tgctaatctg 3198 gattttagag ttggcttctc gggaaaccaa accgttgaca ccccctagaa acttgaaacc 3258 acatcaaaga agtaccagct ggtgctttaa cctcagaagc ttggagaagg ggccctgtgg 3318 agcagggact cagacccctg aggagtgggt gctgcccagc aggcagtgta atgggactca 3378 ttctgaacac gtgaaagagg ctggaagctg gattcagttg ctactagaac atattttgat 3438 aaagacacca gtaaccttca tttcactaaa tccaaaagag aattttcaat cctcaaatta 3498 gcatcacttg accctattga ccactttctc tttgaataat ttctcctgtt gactaccatg 3558 atgtcacatt tttctggttt ttttttctcc tatacctttg gatctcttgt atagattcag 3618 tcttcttcca gttgctaaaa gctgtagttc catccttagt ggctagggaa atgcaaatta 3678 aaatcacaat gaaatatcac tatacaccca ttagaatagc taaaattaaa tggctaaaat 3738 gagaagactg accttaccaa ctactagcga ggatgcagag tgactggaac ttcccgtaca 3798 ttgctgctgg gagtataaaa tgggacttct cctt tggaga atggtttggt agttccttta 3858 aaagttaaac atgtacctac catatgatat tccacttcta gatgtttacc cagcagaaat 3918 tcaagcatat gtcctatgaa gacttcacaa tatttatagg tgctttattt gtagtagccc 3978 caaagtggaa acatcttgaa tgggcatgat ttggtgcatg gataaacaga ttgtatatcc 4038 acacaatgaa taacagccac aaaaaaggga tgaactattc atacacgaac aacatggatg 4098 gactgccaaa gaattaggct gaatgaaaga agaaaaaaaa gactacattt tgattatttc 4158 atttacatac tattccagaa aatacaagtg aatctatagt gacagaaagt gatcaggggg 4218 tttgctggag atggaaatgg ggagaggagg gacagaagga ttgcaaggga acacttggta 4278 actttgggga agagggacgt gttcattttc ttgaatgtaa taatggattt atgggggtat 4338 atatgtcaaa acttaccaaa ttgtacactt ttgttatgtg cagtttattg tgtgtcaatt 4398 atacctcaat aaagttgtta aaaatat <210> 127 <211> 4807 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (60) .. (989) <400> 127 cgcccccctc cggccagccc gcagccggcc gcgtcatgcc aggcgctgct cggcggtag 59 gga gtg ccc ggg gcc gcc gcc tcc gcc cgc ccg aag ccg cgc cca ctg 107 Gly Val Pro Gly Ala Ala Ala Pro Ag Ala Ala Pro Lag gcc aga ggg atg gtg gta gtc acg ggg cgg gag cca gac agc 155 Pro Arg Ala Arg Gly Met Val Val Val Thr Gly Arg Glu Pro Asp Ser 20 25 30 cgt cgt cag gac ggt gcc atg tcc agc tct gac gcc gaa gac gac ttt 203 Arg Arg Gln Asp Gly Ala Met Ser Ser Ser Asp Ala Glu Asp Asp Phe 35 40 45 ctg gag ccg gcc acg ccg acg gcc acg cag gcg ggg cac gcg ctg ccc 251 Leu Glu Pro Ala Thr Pro Thr Ala Thr Gln Ala Gly His Ala Leu Pro 50 55 60 ctg ctg cca cag gag ttt cct gag gtt gtt ccc ctt aac atc gga ggg 299 Leu Leu Pro Gln Glu Phe Pro Glu Val Val Pro Leu Asn Ile Gly Gly 65 70 75 80 gct cac ttc act aca cgc ctg tcc aca ctg cgg tgc tac gaa gac acc 347 Ala His Phe Thr Thr Arg Leu Ser Thr Leu Arg Cys Tyr Glu Asp Thr 85 90 95 atg ttg gca gcc atg ttc agt ggg cgg cac tac atc ccc aca gac tcc 395 Met Leu Ala Ala Met Phe Ser Gly Arg His Tyr Ile Pro Thr Asp Ser 100 105 110 gag ggc cgg tac ttc atc gac cga gat ggc aca cac ttt gga gat gtg 443 Glu Gly Arg Tyr Phe Ile Asp Arg Asp Gly Thr His Phe Gly Asp Val 115 120 125 ctg aat ttc ctg cgc tca ggg gac ctc cca ccc agg gag cgt gtt cga 491 Leu Asn Phe Leu Arg Ser Gly Asp Leu Pro Pro Arg Glu Arg Val Arg 130 135 140 gct gtg tac aaa gag gcc cag tac tat gcc atc ggg ccc ctc ctg gag 539 Ala Val Tyr Lys Glu Ala Gln Tyr Tyr Ala Ile Gly Pro Leu Leu Glu 145 150 155 160 cag ctg gag aac atg cag cca ctg aag ggc gag aag gtg cgc caa gcg 587 Gln Leu Glu Pro Leu Lys Gly Glu Lys Val Arg Gln Ala 165 170 175 ttt ctg gga ctc atg ccc tat tac aaa gac cac ttg gag cgg att gtg 635 Phe Leu Gly Leu Met Pro Tyr Tyr Lys Asp His Leu Glu Arg Ile Val 180 185 190 gag atc gcc cgg ctg cgt gcg gtc cag cgg aag gcc cgc ttt gcc aag 683 Glu Ile Ala Arg Leu Arg Ala Val Gln Arg Lys Ala Arg Phe Ala Lys 195 200 205 ctc aag gtc tgt gtc ttc aag gag gag atg ccc atc ctatgag 731 Leu Lys Val Cys Val Phe Lys Glu Glu Met Pro Ile Thr Pro Tyr Glu 210 215 220 tgt ccg ctc ctc aac tcc ctg cga ttt gag cgg agt gag agt gac ggg 779 Cys Pro Leu Leu Asn Ser Leu Arg Phe Glu Arg Ser Glu Ser Asp Gly 225 230 235 240 cag ctt ttt gag cac cac tgt gaa gtg gat gtg tct ttt ggg ccc tgg 827 Gln Leu Phe Glu His His Cys Glu Val Asp Val Ser Phe Gly Pro Trp 245 250 255 gag gct gtg gct gat gtt tat gac ctg ctg cac tgc ctg gtc acg gac 875 Glu Ala Val Ala Asp Val Tyr Asp Leu Leu His Cys Leu Val Thr Asp 260 265 270 270 ctc tcg gcc cag ggt ctc acc gtg gac cac cag tgc atc ggg gtg Agt 923 Gln Gly Leu Thr Val Asp His Gln Cys Ile Gly Val Cys 275 280 285 gac aag cac ctc gtg aac cac tac tac tgc aag cgc ccc atc tat gag 971 Asp Lys His Leu Val Asn His Tyr Tyr Cys Lys Arg Pro Ile Tyr Glu 290 295 300 ttc aag atc aca tgg tgg tgagtagccc cggtaggcga gagtcccatc 1019 Phe Lys Ile Thr Trp Trp 305 310 agggaggatg tccaccttgc ttggtggctc tgggagtaag atccctgaag gggctgctga 1079 ctgccccaga atgtg gaacag catcctgagg cacagctccc aggggacaga 1139 ggtgtagctc caatctccct gactgcacct cagggttggg ctcagggctt gcggcctgca 1199 ggcactccag ccagcgctca cctggccttt cctcaaggca tggtagtctt tccttgaggc 1259 tgatagctag ggcttgacca ggaagtcccg agaagttttg tcaccttctt gaccttgcaa 1319 gagagtttct gcccatttta gagccacgtt accaaatcga tgtaggccta atcacttcct 1379 caaccctgtt caagcgtccc tcccttgtgc tcagtatatt ggtgtgaaca cggaacatga 1439 tgggggattt acctgaccag ccaccccata gcccctggct gaagaagaaa gagcatcttc 1499 tctcccactg caccccttct cctccaagaa tagttgccca cattcccaaa atgtggaaag 1559 acttttcttt tccttccgga acatgttctt caccaccttt tggagattta accatagctg 1619 ccaaagctat gcacccagtt ggccttagaa aaccacaatg tttacagccc tgtcttaggg 1679 ccgcggcttc tcttatcttc caccaccttc cttgcttgca gggttatctt ctcacagggc 1739 tggaatgcaa atttcagagg cttcttttga agattcccca agtcaagcag gcaagatgcc 1799 tagatcttct gttatctttg acatgtaaca tcctttttag aggctcagaa cacctccttg 1859 gctgctatct catgtgttag aatccagttt gtggtgaacc tctttggaag gggaccccct 1919 ctctttaaac cctgttgctc tgtcctggta acattctcct tctaggagag catctcttct 1979 gagaaggtaa aggaagggct gggtgagaca cacagctatc ctaggagccg taggaagaca 2039 aaacttccct tttgttttac tcctcactcc tctatttttg ttttactcac ttctttatat 2099 tttgttttac tcctcactcc tgtatatttt ggtttactta ctcctctatt tcagaaattg 2159 aaaaagatcc ccaaggatct gttactactg catttccttc ttgctctgtc tacagcctag 2219 gccaactagt cagggtctgg acatgcatct cctaaaggaa gaactgtgta gcaccattga 2279 tcacaatgta acatttccat gctgcattaa gggtgtctct ctctaatcat gattgtacct 2339 gtctcttcct gggtaaaggg agattttttt ttttttaatg tgtaaagaat tgatgcgagc 2399 caggaacatg tctgtagtcc cagctacttg ggcacacgcc tgtagtccag gccactcgag 2459 cacacacctg tagtaccagc tactctggag gctgaggcag gaggatcact tgagcccagg 2519 agattaagac tgtagtatac tatgatcgtg cctgtggcta gccactgtgc tccagcctgg 2579 gcaacaccat cgtaaaaata aataaataaa taaataaatt ggggaggaca gcctcactgg 2639 tatcagactt acaggaccag atagacaaga tgggtataag gggagctgaa gtctgtgttc 2699 atatgaggaa gagaagacca agccctggga ctttggctga attcctccgt ggggctggac 2759 ggcagtgatc tcctgttccc tatgtgtaaa caaa gattcc agggcgtggt tttgcactcc 2819 tgttgtactc ttttagaggt ggaaaagagg tggatactga gatctaagag gaaaggatag 2879 tcattcacgt tctgagatat gcgctctctc tattgttctc gtacacaaag ggatagtctc 2939 ttttctggag ctgatgtccc tgcttggagg ttagccccaa aacatggctc ttgtattgtt 2999 ctaagagaaa aggctttcat tttggttctt ctgattggtg ttacctactg cctaatatgt 3059 gttcattttt tgacagagag gcagactatt gaaaaagtct gtgtgaacag agagcagttc 3119 attaagccca ttgctttcag taatgtggcc ttgacccctt ctgcttcccc cttctcccat 3179 ggagcatggc agggcttggt tatttagagt ccatacatgc aagccattga gagacttgtt 3239 tgctcaaatg caagtttgct caaaaacagg tcctgaaggc ttgcttagga ttacagggat 3299 gctgggtaag aacaccgttc ctctctctcg ctggagaaat ccctgtttct ctgactccct 3359 ttgtgatcct cacagtaatg tattctgtgc cactgtagga cacaaggctc tgggccagta 3419 gaacaggcag agaggtgaca ctgggcagca agctgagagc tctttctaaa tggagtgaag 3479 gaattcagtg gcctagtttc gccattctct aatgagaaac caaggccagg ctgaaaagtg 3539 caattagatg tggtggattg tggtaacggc ctccagataa aggggttatc cctgtggaag 3599 tgacttttcc ccatttgatc ccttttcaac tctaaatggc caggcccaga gcagaagaag 3659 ggttgggtct ggaaggaagg ctccaaagga tgaaagcttc tccctgatca taaggaagtg 3719 catctttata gaattgttgt gcataatgtc agtaaatccc tctcacttga caagggactg 3779 gattcatctt gccttgagac gggccagtag ttatcagtga gtcaaagcaa agtgaaagtt 3839 tcaggagatg ggaccaatgg tgcaatgctc gccataacaa aattccttaa aaataaaaaa 3899 gctaatgtta tagcaacaaa aaaagactga agcaaaacca cactgaaatg catcccactc 3959 caggagagga attcttagcg taacactcta aataaatgga aggaatcatc accttcctta 4019 ttttacctct gccttgttca ccaggctgcc cagtgcttac catgcagaaa gcagtcagct 4079 gtactctgga agtttctgtt cttctttcct ggggcttagg atattctggg agctgtctga 4139 gccttgtgcc taaggcttat caggtgatat aatcttcctg ttctgggctg cttgctggag 4199 gaataggaag tgacatttat aagacacagg cggtgtgagc atccatgtgt ggtcttggtc 4259 taaaccagct cttgaacagg ttaaagcaaa cagcaataac aaaacaaaaa ctactgatgc 4319 tgagcgtttt gatcctagta atatttcaaa tattgtcctt ctgcatatgt tctatccata 4379 tttgattcca atatacatta ttaagctttc ttgggtacta ttttgctggg gctcttgcgt 4439 gaaggtggta cctgtctcat gatccttaaa agagagaggc tttt ttcatc caaagctgta 4499 gtgttgggaa ctggggtggg agaggcactt tttggaattc tgaaagaatc atatctgtgt 4559 atatacatac tgagtgggga aggatggggg ttggcagggg ttgagggagg tgggaacaaa 4619 cagtgagtat gggaacaggc agtcacctcg agtgtgggag gtcacctggg tccgtcgtct 4679 tccttctgta tggtgttggg tttatgtaca cactataaca cttcctgtgt gagttcatgt 4739 acctgtgtgt gagtgctttg gtgtattgag cctcagtaca ctccaagggc attaaagtca 4799 agaactag 4807 <210> 128 <211> 3675 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (366) .. (2270) <400> 128 gtgagagaga gaggagagga gaggaggagg aggaggaggg agaagggaac aacctaccat 60 cttaacacac taatatctaa aaagtgcgag aggcccagag cagcagcaga agcagcagca 120 gcagctccag cttcttccct ccctccccat gaagaagagt tccctcctcc tcctcctcct 180 gcttctcctg ctcagagttc ctgcctccag ctgccagggg ggacagccag ccagcagcag 240 gaggggggct agagagctga aggagagcca gtttccccaa aattgctgca gtgagaagag 300 gagtttgtta ctttaaacag aggctgaaga aactatagaa ttagcagaga aagtggagaa 360 ggtag agg atg gag ttg cag act cta cag gag gct ctt aaa gtg gaa att 410 Arg Met Glu Leu Gln Thr Leu Gln Glu Ala Leu Lys Val Glu Ile 1 5 10 15 cag gtt cac cag aaa ctg gtt gct caa atg aag cag gat cca cag aat 458 Gln Val His Gln Lys Leu Val Ala Gln Met Lys Gln Asp Pro Gln Asn 20 25 30 gct gac tta aag aaa cag ctt cat gaa ctc caa gcc aaa atc aca gct 506 Ala Asp Leu Lys Lys Gln Leu His Glu Leu Gln Ala Lys Ile Thr Ala 35 40 45 ttg agt gag aaa cag aaa aga gta gtt gaa cag cta cgg aag aac ctg 554 Leu Ser Glu Lys Gln Lys Arg Val Val Glu Gln Leu Arg Lys Asn Leu 50 55 60 ata gta aag caa gaa caa ccg gac aag ttc caa ata cag cca ttg cca 602 Ile Val Lys Gln Glu Gln Pro Asp Lys Phe Gln Ile Gln Pro Leu Pro 65 70 75 caa tct gaa aac aaa cta caa aca gca cag cag caa cca cata caa 650 Gln Ser Glu Asn Lys Leu Gln Thr Ala Gln Gln Gln Pro Leu Gln Gln 80 85 90 95 cta caa caa cag cag cag tac cac cac cac cac gcc cag cag tca gct 698 Leu Gln Gln Gln Gln Gln Tyr His His His Ala Gln Gln Ser Ala 100 105 110 gca gcc tct ccc aac ctg act gct tca cag aag act gta act aca gct 746 Ala Ala Ser Pro Asn Leu Thr Ala Ser Gln Lys Thr Val Thr Thr Ala 115 120 125 tct atg att acc aca aag aca cta cct ctc gtc ttg aaa gca gca act 794 Ser Met Ile Thr Thr Lys Thr Leu Pro Leu Val Leu Lys Ala Ala Thr 130 135 140 gcg acc atg cct gcc tct gtg gtg ggc cag aga cct acc att gct atg 842 Ala Thr Met Pro Ala Ser Val Val Gly Gln Arg Pro Thr Ile Ala Met 145 150 155 gtg acc gcc atc aac agt cag aag gct gtg ctc agc act gat gtg cag 890 Val Thr Ala Ile Asn Ser Gln Lys Ala Val Leu Ser Thr Asp Val Gln 160 165 170 175 aac aca cca gtc aac ctc cag acg tct agt aag gtc act ggg cct ggg 938 Asn Thr Pro Val Asn Leu Gln Thr Ser Ser Lys Val Thr Gly Pro Gly 180 185 190 gca gag gct gtc caa att gtg gca aaa aac aca gtc act ctg cag gtt 986 Ala Glu Ala Val Gln Ile Val Ala Lys Asn Thr Val Thr Leu Gln Val 195 200 205 cag gca aca cct cct cag ccc atc aaa gta cca cag ttt atc ccc cct 1034 Gln Ala Thr Pro Pro Gln Pro Ile Lys Val Pro Gln Phe Ile Pro Pro 210 215 220 cct aga ctc act cca cgt cca aac ttt ctt cca cag gtt cga ccc aag 1082 Pro Arg Leu Thr Pro Arg Pro Asn Phe Leu Pro Gln Val Arg Pro Lys 225 230 235 cct gtg gcc cag aat aac att cct att gcc cca gca cca cct ccc atg 1130 Pro Val Ala Gln Asn Asn Ile Pro Ile Ala Pro Ala Pro Pro Met 240 245 250 255 ctc gca gct cct cag ctt atc cag agg ccc gtc atg ctg acc aag ttc 1178 Leu Ala Ala Pro Gln Leu Ile Gln Arg Pro Val Met Leu Thr Lys Phe 260 265 270 acc ccc aca acc ctt ccc aca tcc cag aat tcc atc cac ccc gtc cgt 1226 Thr Pro Thr Thr Leu Pro Thr Ser Gln Asn Ser Ile His Pro Va l Arg 275 280 285 gtc gtc aat ggg cag act gca acc ata gcc aaa acg ttc ccc atg gcc 1274 Val Val Asn Gly Gln Thr Ala Thr Ile Ala Lys Thr Phe Pro Met Ala 290 295 300 cag ctc acc agc att gtg ata gct act cca ggg acc aga ctc gct gga 1322 Gln Leu Thr Ser Ile Val Ile Ala Thr Pro Gly Thr Arg Leu Ala Gly 305 310 315 cct caa act gta cag ctt agc aag cca agt ctt gaa aaa cag aca gtt 1370 Pro Gln Thr Val Gln Leu Ser Lys Pro Ser Leu Glu Lys Gln Thr Val 320 325 330 335 aaa tct cac aca gaa aca gat gag aaa caa aca gag agc cgc acc atc 1418 Lys Ser His Thr Glu Thr Asp Glu Lys Gln Thr Glu Ser Arg Thr Ile 340 345 350 acc cca cct gct gca ccc aaa cca aaa cgg gag gag aac cct cag aaa 1466 Thr Pro Pro Ala Ala Pro Lys Pro Lys Arg Glu Glu Asn Pro Gln Lys 355 360 365 ctt gcc ttc atg gtg tct cta ggg ttg gta aca cat gac cat cta gaa 1514 Leu Ala Phe Met Val Ser Leu Gly Leu Val Thr His Asp His Leu Glu 370 375 380 gaa atc caa agc aag agg caa gag cga aaa aga aga aga aca aca gca aat 1562 Glu Ile Gln Ser Lys Arg Gln Glu Arg Ly s Arg Arg Thr Thr Ala Asn 385 390 395 ccg gtc tac agt gga gca gtc ttt gag cca gag cgt aag aag agt gca 1610 Pro Val Tyr Ser Gly Ala Val Phe Glu Pro Glu Arg Lys Lys Ser Ala 400 405 410 415 gt gtg aca tac cta aac agc aca atg cac cct ggg acc cgg aag aga gcc 1658 Val Thr Tyr Leu Asn Ser Thr Met His Pro Gly Thr Arg Lys Arg Ala 420 425 430 aat gag gaa cac tgg cca aag ggt gat att cat gag gat ttt tgc agc 1706 Asn Glu Glu His Trp Pro Lys Gly Asp Ile His Glu Asp Phe Cys Ser 435 440 445 gtt tgc aga aaa agt ggc cag tta ctg atg tgc gac aca tgt tcc cgt 1754 Val Cys Arg Lys Ser Gly Gln Leu Leu Met Cys Asp Thrs Ser Arg 450 455 460 gta tat cat ttg gac tgc tta gac ccc cct ctg aaa aca att ccc aag 1802 Val Tyr His Leu Asp Cys Leu Asp Pro Pro Leu Lys Thr Ile Pro Lys 465 470 475 ggc atg tgg atc tgt ccc aga tgt cag gac cag atg ctg aag aag gaa 1850 Gly Met Trp Ile Cys Pro Arg Cys Gln Asp Gln Met Leu Lys Lys Glu 480 485 490 495 gaa gca att cca tgg cct gga act tta gca att gtt cat tcc tat att 1898 Glu Ala Ile Pro Trp Pro Gly Thr Leu Ala Ile Val His Ser Tyr Ile 500 505 510 gcc tac aaa gca gca aaa gaa gaa gag aaa cag aag tta ctt aaa tgg 1946 Ala Tyr Lys Ala Ala Lys Glu Glu Glu Lys Gln Lys Leu Leu Lys Trp 515 520 525 agt tca gat tta aaa caa gaa cga gaa caa cta gag caa aag gtg aaa 1994 Ser Ser Asp Leu Lys Gln Glu Arg Glu Gln Leu Glu Gln Lys Val Lys 530 535 540 cag ctc agc aat tcc ata agt aaa tgc atag gaa aac acc atc 2042 Gln Leu Ser Asn Ser Ile Ser Lys Cys Met Glu Met Lys Asn Thr Ile 545 550 555 ctg gcc cgg cag aag gag atg cac agc tcc ctg gag aag gta aaa cag 2090 Leu Ala Arg Gln Lys Glu Met His Ser Ser Leu Glu Lys Val Lys Gln 560 565 570 575 ctg att cgc ctc atc cac ggc atc gac ctc tcc aaa cct gta gac tct 2138 Leu Ile Arg Leu Ile His Gly Ile Asp Leu Ser Lys Pro Val Asp Ser 580 585 585 590 gag gcc gt ggg gcc atc tcc aat ggc ccg gac tgc acc ccc cct 2186 Glu Ala Thr Val Gly Ala Ile Ser Asn Gly Pro Asp Cys Thr Pro Pro 595 600 605 gcc aat gcc gcc acc tcc acg ccg gcc cct tcc ccc tcc tcc cag agc 2 234 Ala Asn Ala Ala Thr Ser Thr Pro Ala Pro Ser Pro Ser Ser Gln Ser 610 615 620 tgc aca gcg aac tgt aac cag ggg gaa gag act aaa taacagagcc 2280 Cys Thr Ala Asn Cys Asn Gln Gly Glu Glu Thr Lys 625 630 630 635 cctctagg aagccacggg atcccggcgg caaggagaac agaacactga agactctaga 2340 aaagcaaagc cggatttctg gaaagtgcag aattcttttg gttctttggt tccagagaga 2400 gagaagatgc ttgtgccagg tggcaccaga gtttgccaat tgatccttct tattctgtgt 2460 gtacatgcaa agattggacc atgttacatg aaatagtgcc agctggaggt tctttgccag 2520 caccatgcca agtgaaataa tatatttact ctctctatta tacaccagtg tgtgcctgca 2580 gcagcctcca cagccacgat gggtttgttt ctgttttctt gggtggggag cagggacggg 2640 cggagggagg agagcaggtt tcagatcctt acttgccgag ccgtttgttt aggtagagaa 2700 gacaagtcca aagagtgtgt gggctttcct gtttctaaac tttcgctact ataaaaccaa 2760 aaaaaggaat tgagatttca ccaaccccag tgcccagaag agggaagggg agtggctgga 2820 gggagcaggg ggtgggacag tgtatcaaat aagcagc cc gagccc gagccc gagccc gagccc gagccc cc gagccc gagccc gagccc gagccc gcgcgcccagc 2 acccca ccactcctga agcctgccca gtctccttcc ttccctgctt 3000 ggtgagtcgc gcatctccgt ggttatcccg ctgtctcctc tccaagaaca agcagagccc 3060 gggccactgg cccttgccca aggcagggaa gaaggatgtg tgtgtccagg aaggaaaaaa 3120 aggtggatca gtgattttac ttgaaaacaa gctccatccc ttttctatat ttataagaag 3180 agaagatctt gagtgaagca gcacgcgacc caggtgtgtg tgaattgaat ggagacgttt 3240 cttttctctt tctttaattt ttgtttttgt tctttttttc tttaaggaaa gttttatttt 3300 actgttcatt ttactttctt ggtaacaaaa actaaaataa ggaatagaaa agctgttttt 3360 caggctgaca gtccaattaa gggtagccaa gaccttgcat ggtagagtag gaatcatagt 3420 gtcagtgagg tcccgtgagt ctttgtgagt ccttgtgtca tcgttcgggc actgtttttt 3480 tatgcaaggg caaaaatctt tgtatctggg gaaaaaaaac ttttttttaa attaaaaagg 3540 aaaataaaag atattgaggt cttcctagtg ttacttaaat taagatcaag gtaagaaaca 3600 ttgtaaaaaa aaattacaaa agtgctattt gtttcctaaa aacagtgatt tctattaaaa 3660 aggtgtcaga actgg 3675 <210> 129 <211> 3641 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (622) .. (2790) <400> 129 ctggccctcg ccccaggggg cccgtcgggg agaggacgca gctcgtaggg gggtccccgg 60 ggagaggaag agacagcccc tttcgagctt ccacgcacca gccactccgg ggagggggcc 120 aagaggcaac ggcggccacc accgggcacc ctcgccccct cccctcgggc cgggagcttc 180 cagcccaagt ctgcagcacc aggaagaagg cgcctgagct cccctcgcga cgagtcaacc 240 gcagtaggag gtgggggcga agagagggct gaacccgtcc gctgcccggg cggtggagcc 300 cccacggcga ggcgctgcgc cggcggtgga gactcgcgtt ccctccagcc cctggggcag 360 aactttctcg ccccccctcc tccctccccc gcagtcggac tccctcccca gccggccagt 420 cctcccggag gagaaggcgc cgcggagaca gcccgggcgg gggcctacct tccccagggc 480 aggcatcatg tcggcggcgc aggtgtcctc gtcccggaga caatcttgct acctgtgcga 540 cctgccccgc atgccctggg ccatgatctg ggacttctcg gaacccgtat gccgcggttg 600 cgtcaactac gagggcgctg a tcg cat cga att cgt gat cga gac agc gcg 651 Ser His Arg Ile Arg Asp Arg Asp Ser Ala 1 5 10 cca gct gaa gcg ggc gca cgg ctg ctt cca gga cgg ccg ctc ccc cgg 699 Pro Ala Glu Ala Gly Ala Arg Leu Leu Pro Gly Arg Pro Leu Pro Arg 15 20 25 gcc gcc gcc gcc gcg caa cag caa ca g caa cag cag cag cag cag cag 747 Ala Ala Ala Ala Ala Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 30 35 40 caa cag cag cag cag cag cag cag cag caa caa cag ctc aac cac gtt 795 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Asn His Val 45 50 55 gat ggt tcc agc aag cct gcg gtg ctg gcg gcc ccg tct ggc ctg gag 843 Asp Gly Ser Ser Lys Pro Ala Val Leu Ala Ala Pro Ser Gly Leu Glu 60 65 70 cgc tac ggc cta agc gct gcc gcc gcc gcc gcc gcc gcc gcc gcc gcc 891 Arg Tyr Gly Leu Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 75 80 85 90 gcg gtg gaa cag cgc agc cgc ttg gag ccg gtg agc 939 Ala Val Glu Gln Arg Ser Arg Phe Glu Tyr Pro Pro Pro Pro Ser Ser 95 100 105 ctg gga agc agc agc cac acc gcg cga ctg ccc aac ggc ctg ggg ggc 987 Leu Gly Ser Ser Ser His Thr Ala Arg Leu Pro Asn Gly Leu Gly Gly 110 115 120 cca aac ggc ttc ccc aaa cca aca cca gag gag gga ccc cca gag ctg 1035 Pro Asn Gly Phe Pro Lys Pro Thr Pro Glu Glu Gly Pro Pro Glu Leu 125 130 135 aac cgt cag agc ccc aat tct tct tca gcg gcg gcg tcg gtg gcg tct 1083 Asn Arg Gln Ser Pro Asn Ser Ser Ser Ala Ala Ala Ser Val Ala Ser 140 145 150 cgg cgt gga acg cac ggt ggg ctg gtt acg ggg ctg ccc aac ccg ggg 1131 Arg Arg Gly Thr His Gly Leu Val Thr Gly Leu Pro Asn Pro Gly 155 160 165 170 ggt ggc gga ggc ccc cag ctc acc gtg ccc ccc aac ctg cta ccg cag 1179 Gly Gly Gly Gly Gly Pro Gln Leu Thr Val Pro Pro Asn Leu Leu Pro Gln 175 180 185 acg ctg ctt aac ggc ccg gcc agc gct gcg gta ctc ccc cca ccc cct 1227 Thr Leu Leu Asn Gly Pro Ala Ser Ala Ala Val Leu Pro Pro Pro Pro 190 195 200 ccc cac gcc ctg ggc agc cgt ggg ccc ccg acg cct cca ggg 1275 Pro His Ala Leu Gly Ser Arg Gly Pro Pro Thr Pro Ala Pro Pro Gly 205 210 215 gct cct ggg ggc ccc gct tgt ctc ggg ggt acc ccg ggt gta tcg gcc 1323 Ala Pro Gly Gly Pro Ala Cys Leu Gly Gly Thr Pro Gly Val Ser Ala 220 225 230 acg tcg tcc tcc gcg tcg tct tcg acc tct tcg tcg gtg gca gag gtg 1371 Thr Ser Ser Ser Ala Ser Ser Ser Thr Ser Ser Ser Val Ala Glu Val 235 240 245 250 ggc gtg ggt gct ggt ggt aag agg ccc ggc tcg gtg tcg agc aca gac 1419 Gly Val Gly Ala Gly Gly Lys Arg Pro Gly Ser Val Ser Ser Thr Asp 255 260 265 cag gag cgc gag ttg aag gag aag cag cgc aac gcc gag gcc ccg gcc Gln Glu Arg Glu Leu Lys Glu Lys Gln Arg Asn Ala Glu Ala Leu Ala 270 275 280 gag ctg agc gag agc ctg cgc aac cgc gcc gag gag tgg gcc agc aag 1515 Glu Leu Ser Glu Ser Leu Arg Asla Gla Ser Lys 285 290 295 ccc aag atg gtc cgc gac acg ctg ctc acg ctg gca ggc tgc acg ccc 1563 Pro Lys Met Val Arg Asp Thr Leu Leu Thr Leu Ala Gly Cys Thr Pro 300 305 310 tac gag gtt cgc ttc cag aag ag tcg ctg ctg ggc cgc gtt ttc 1611 Tyr Glu Val Arg Phe Lys Lys Asp His Ser Leu Leu Gly Arg Val Phe 315 320 325 330 gcc ttc gac gcc gtc tcc aag ccc ggc atg gac tac gaa ttg aag Phe Aspla Ser Lys Pro Gly Met Asp Tyr Glu Leu Lys Leu 335 340 345 ttc att gag tac ccc acg ggc tcg ggc aac gtg tac tcc agt gca tct 1707 Phe Ile Glu Tyr Pro Thr Gly Ser Gly Asn Val Tyr Ser Ser Ala Ser 350 3 55 360 ggt gtg gcc aag cag atg tat cag gac tgc atg aag gac ttc ggc cgg 1755 Gly Val Ala Lys Gln Met Tyr Gln Asp Cys Met Lys Asp Phe Gly Arg 365 370 375 375 ggc cta tcc tcg ggt ttc aag tac g aag aag cac ggc 1803 Gly Leu Ser Ser Gly Phe Lys Tyr Leu Glu Tyr Glu Lys Lys His Gly 380 385 390 tcc ggg gac tgg cgc ctg ctt gga gac ctg ctc ccc gaa gcc gtg cgc 1851 Ser Gly Asp Tp Arg Lep Leu Leu Pro Glu Ala Val Arg 395 400 405 410 ttc ttc aag gag ggc gtg ccc ggc gcc gac atg ctg ccc cag ccc tac 1899 Phe Phe Lys Glu Gly Val Pro Gly Ala Asp Met Leu Pro Gln Pro Tyr 415 420 425 ctg gac agc tgt ccc atg ctg ccc act gct ctg gtg agt ctg agc 1947 Leu Asp Ala Ser Cys Pro Met Leu Pro Thr Ala Leu Val Ser Leu Ser 430 435 440 cgc gcc ccc agc gca ccc ccg ggg acc ggg gcc ccg gcc gcc Arg Ala Pro Ser Ala Pro Pro Gly Thr Gly Ala Leu Pro Pro Ala Ala 445 450 455 ccg tcg ggc cgg ggc gca gcc gcc agc ctg cgc aag aga aag gcc tct 2043 Pro Ser Gly Arg Gly Ala Ala Ala Ser Leu Arg Lys A rg Lys Ala Ser 460 465 470 ccg gag ccc ccg gac tca gcc gag ggc gcg ctg aag ctg ggc gag gaa 2091 Pro Glu Pro Pro Asp Ser Ala Glu Gly Ala Leu Lys Leu Gly Glu Glu 475 480 485 490 490 cag cag agg cagg agg atg gcg aac cag agc gag gcg ctg aag ctc 2139 Gln Gln Arg Gln Gln Trp Met Ala Asn Gln Ser Glu Ala Leu Lys Leu 495 500 505 acc atg tcc gcc ggg ggc ttc gcg gcg ccg ggg cac gcg gg Thrg Ala Gly Gly Phe Ala Ala Pro Gly His Ala Ala Gly Gly 510 515 520 ccg cct ccg ccg ccc cca cct ctg gga ccc cat tcc aac cgg acc acc 2235 Pro Pro Pro Pro Pro Pro Pro Leu Gly Pro His Ser Asn Arg Thr Thr 525 530 535 cca cct gag tca gcc ccc cag aac ggt ccg tcc cct atg gcc gct ctc 2283 Pro Pro Glu Ser Ala Pro Gln Asn Gly Pro Ser Pro Met Ala Ala Leu 540 545 550 atg tcg gtg gca gat act ctg ggc aca gcg cac ccc aag gat ggc 2331 Met Ser Val Ala Asp Thr Leu Gly Thr Ala His Ser Pro Lys Asp Gly 555 560 565 570 agt tcc gtg cac tct acc act gcg tcg gcg cgg cga aac agc agc agc 2379 Ser Ser Val His Ser Thr Th r Ala Ser Ala Arg Arg Asn Ser Ser Ser 575 580 585 cca gtc tcg ccg gcc tcc gtg ccg ggg cag cgc cgc ttg gca tca cgt 2427 Pro Val Ser Pro Ala Ser Val Pro Gly Gln Arg Arg Leu Ala Ser Arg 590 595 600 aac ggg gac ctg aat tta cag gtg gcg ccc ccg ccg cct agc gcc cac 2475 Asn Gly Asp Leu Asn Leu Gln Val Ala Pro Pro Pro Pro Ser Ala His 605 610 615 615 ccg ggc atg gac caa gtg cac ccc caa aat tccg atg 2523 Pro Gly Met Asp Gln Val His Pro Gln Asn Ile Pro Asp Ser Pro Met 620 625 630 gcc aac agc gga ccc ctc tgc tgc acc att tgc cac gaa cgt ttg gag 2571 Ala Asn Ser Gly Pro Leu Cys Cys Thr Ile Cys His Glu Arg Leu Glu 635 640 645 650 gat acg cat ttc gtt cag tgc cct tcc gtc ccc agc cac aaa ttt tgc 2619 Asp Thr His Phe Val Gln Cys Pro Ser Val Pro Ser His Lys Phe Cys 655 660 665 ttc cct tgc tct gag agt atc aag gcc cag ggg gcc acc ggc gag 2667 Phe Pro Cys Ser Arg Glu Ser Ile Lys Ala Gln Gly Ala Thr Gly Glu 670 675 680 gtg tat tgc ccc agc gga gag aaa tgc ccc cta gtc ggg tcg aat gta 2715 Val Cys Pro Ser Gly Glu Lys Cys Pro Leu Val Gly Ser Asn Val 685 690 695 cct tgg gcc ttc atg cag ggc gaa atc gcg act atc tta gct ggg gat 2763 Pro Trp Ala Phe Met Gln Gly Glu Ile Ala Thr Ile Leu Ala Gly Asp 700 705 710 gtt aaa gtg aaa aag gag aga gac cct tgaaccactg ggcagccacc 2810 Val Lys Val Lys Lys Glu Arg Asp Pro 715 720 tcctttgccc tagaccagct cctctccaat cctgagggcc cctcccccaa cccaactcga 2870 ccctccctcc cctcaccccc aaggtgtaga attgtgaata taacgaaact gcaaaaagtt 2930 agtcttatgt atagacatta ttttcgtcgt atgtttctat attttgaaac aaaggtatgt 2990 aacttcttca tttgaaggat aagctggttt gtgttaagca gtatagtatt ggttgggtca 3050 tttgcatcat atcgttagca tttatttggt ggcagaatgt ttgcctaggt acagaattaa 3110 tagcccttag caacgactgc tgctggtgtg tatttttgta aatgttatgc actctctgaa 3170 aggaaaaaca cacacaaaag aaaaagactt tttttttttt tttttttttg ccaaggccag 3230 tgttgctgcc taaaaaaaaa aaaaaaaaaa aaaaaaaaat gctataaaat ggtgaaagct 3290 tccttctaaa ctgccccaag tgttgaagtc ttcactttat tttgttctgt tttgttttgt 3350 ttttctgttt tgtttgcaaa atggtaaggg ggtgtc gggg gggatggggt gtattttgtt 3410 gcaagtttgt gaggggaaaa tgttttggtt tgtttctact gacctgaatg tgttggatct 3470 acacgtgttg ttttgttttt gctttattga tgcacggatg cttttgaaca gtagagcgaa 3530 atgctagaca tggagaatct gctctgtttg tcctttatac atttctgtag ttaacagaac 3590 actgtaatgt gccttggagc ttagtaactt gtaataaatt caattgatat t 3641 <210> 130 <211> 4605 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2668) .. (4209) <400> 130 gcggtagcgg cggcggcggc ggcggcggcg gcggcggcgg cggcggcgcg gcgtgtggag 60 cgagggagcg gcgcgagcgg cggcatgacg cggaggcgga gcaggccgag cggcggtgcg 120 ggcaggcgcg agcgggctcg ggccgcgggg ccgcagaagc cccaggcgcc cgagcccccg 180 ccgccgccaa gcctggaggc gggagcgggt gcaggccctc cggaggcgcc ggcggagccc 240 gaccacgacg gccccaggga ggatgacgaa cccaacctgg tgcccggccc gcaggtagga 300 gcgagcgggg agacttcggc ggctcgggcg ctttcacctt ccccgagcgg gagcgggagt 360 ggggcggggt tggggatggg ccatcctgcc gcggctgggg tagcagcctt cccccgggtc 420 cggcgccgaa gctttctccc ccggggcggg aatggaggct ggacccctct ccccaaagcc 480 gaggctcggt ccgcgctcct gcgactaggc tgaagctgct cccctctccc cgccgcctcc 540 gggcgttccg gccgtacacc cacactggga ctgggactgg gactgggctg tgatcccgag 600 gccgcagctc cgctctcggc ccgccacctc ccccgggccc acctgctccc tcagccacag 660 gccatctcgg ggctctggga ctggacgact gcagcctctt ccctctgccc ccgggaacgg 720 ctccactccg tcccctgcag cgcctgcagc cgcggccccc tcagcagctg tgtctcctgg 780 cgcctcctcg ccatacccag cagagcagtt ggagcagaca gccaggctgc ccggaggagt 840 ttttggtggg gtttctgcac tgaggtggaa acccagcaga acctgccctt cttccctccc 900 ctgctccgca aggcagccca ccccgacctt gagatcccag gtttggagaa tcctgctgag 960 agcgaacagt aggaggattc cccaaagctt ccagcttgcc acctggaaga aggtcacttt 1020 cttttgagca aaggagataa cgggaggtac cctgccaaag ttcactgaga ggcgggggtg 1080 acatgggcca cggttgctct gggagggttg tggcactcgg ggctgggtgg ctctccctaa 1140 gcttgctctg acaaaagagt tttgagttgg tcttttggct gagcctgccc aggaaggcag 1200 gctcctgcag gagtcttgga gggtcggatg cggcgccgga tgaggatgag gcgtggcgga 1260 agatgcgttt ggctctgcag acactgcatc gggcagcagg ggactctggg aggctggtgc 1320 agccagaagg catggctctt gacagccttc tagtagaatc tctggaattg tgcatatgaa 1380 gaaacagaaa ctcagagcaa ctaaacattt gcccaaatga ctccaactgt aggtgtcaga 1440 caaaagaaaa gaaaaggact tttaggtccc ccccgcctcc agccagcctg tgcagacttg 1500 ctgcctgctg tgtcaccggg aacgcaaagg ctgggaagaa ggcccttctc aaaatggact 1560 ggtgttgcag ggtgagaagc tgccccctga cttcatgcca aagctcgtca agaatctcct 1620 aggcgagatg cctctgtggg tctgccagag ttgccgaaag agcatggagg aagatgaaag 1680 gcagacaggt cgagaac atg cagtggcgat ctccttgtca cacacatcct gcaaatcaca 1740 gtcttgtgga gatgactctc attcgtcctc gtcttcctcc tcatcatcct catcctcgtc 1800 ctcctcttcc tgccctggga actcgggaga ctgggatcct agctcgttcc tgtcggcaca 1860 taagctctcg ggcctctgga attccccaca ttccagtggg gccatgccag gcagctctct 1920 tgggagtcct cctaccatcc ccggtgaggc tttccccgtc tcggagcacc accagcactc 1980 agacctcact gctcccccta acagccccac cggccaccac ccgcagccag catctctaat 2040 cccgtctcac cccagctcct ttggctcccc accccaccca cacctgctgc ccaccacccc 2100 ggcagcacct ttccctgccc aggcttcaga gtgccctgtt gctgctgcca ctgcccccca 2160 cactccaggg ccatgtcaga gctcccatct accctccacc agcatgccgc tcctgaagat 2220 gcccccacca ttctcggggt gcagccaccc ctgcagcggg cactgtggtg ggcactgcag 2280 tgggcctctc ctcccacccc cgagctctca gccactccct agcactcaca gggatcccgg 2340 gtgcaagggg cacaagtttg cacacagtgg cctggcttgc cagctgcccc agccctgcga 2400 ggcagatgag gggctgggtg aggaagagga tagcagctct gagcgaagct cctgcacctc 2460 atcctccacc caccagagag atgggaagtt ctgtgactgc tgctactgtg agttcttcgg 2520 ccacaatgcg gcaaaaggaa a ggaaatggc agagagaaag ctatgattct gatgagtatg 2580 tatacgtgtg taatcccaga gaagtgaacg cttgggagtg atgaaggcag agtggaagca 2640 aaaaggctct cagtccccca agtgtga cag cca gcc gag gga cag gg Ag gag Ag gag Ag gc Gag Gg Ag Gag Ag gag Gag Ag Gag Ag Gag Ag Gag Ag Gag Ag Gag Ag Gag Ag Gag Ag Gag Ag Gag Ag Gag Ag ggc tct 2742 Thr Asp Gly Ala Arg Lys Glu Ala Gln Ile Arg Gly His Ala Gly Ser 10 15 20 25 ggc cag ggg gag gaa gca gtg cag aag tct cat aag cca ccc gct gcc 2790 Gly Gln Gly Glu Glu Ala Val Gln Lys Ser His Lys Pro Pro Ala Ala 30 35 40 ccg acg agt cgg aac tat acc gag atc cgg gag aag ctc cgc tcg agg 2838 Pro Thr Ser Arg Asn Tyr Thr Glu Ile Arg Glu Lys Leu Arg Ser Arg 45 50 55 ctg acc agg cgg aaa gag gag ctg ccc atg aag ggg ggc acc ctg ggc 2886 Leu Thr Arg Arg Lys Glu Glu Leu Pro Met Lys Gly Gly Thr Leu Gly 60 65 70 ggg atc cct ggg gag ccc gcc gtg gac cac cga gat gtg gat gag ctg 2934 Gly Pro Gly Glu Pro Ala Val Asp His Arg Asp Val Asp Glu Leu 75 80 85 ctg gaa ttc atc aac ag agc acg gag ccc aaa gtc ccc aac agc g cc agg 2982 Leu Glu Phe Ile Asn Ser Thr Glu Pro Lys Val Pro Asn Ser Ala Arg 90 95 100 105 gcc gcc aag cgg gcc cgg cac aag ctg aaa aag aag gaa aag gag aag 3030 Ala Ala Lys Arg Ala Arg His Lys Leu Lys Lys Lys Glu Lys Glu Lys 110 115 120 gcc cag ttg gca gca gaa gct cta aag cag gca aat cgt gtt tct gga 3078 Ala Gln Leu Ala Ala Glu Ala Leu Lys Gln Ala Asn Arg Val Ser Gly 125 130 135 agc cgg gag cca agg cct gcc agg gag agg ctc ttg gag tgg ccc gac 3126 Ser Arg Glu Pro Arg Pro Ala Arg Glu Arg Leu Leu Glu Trp Pro Asp 140 145 150 cgg gaa ctg gat cgg gtc aac agc ttc ctg agc agc cgt ctg cag Leu Asp Arg Val Asn Ser Phe Leu Ser Ser Arg Leu Gln Glu 155 160 165 atc aaa aac act gtc aaa gac tcc atc cgt gcc agc ttc agt gtg tgt 3222 Ile Lys Asn Thr Val Lys Asp Ser Ile Arg Ala Ser Phe Ser Val Cys 170 175 180 185 gag ctc agc atg gac agc aat ggc ttc tct aag gag ggg gct gct gag 3270 Glu Leu Ser Met Asp Ser Asn Gly Phe Ser Lys Glu Gly Ala Ala Glu 190 195 200 cct gag cct cag agt cta ccc ccc tca aac ctc agt ggc tcc tca gag 3318 Pro Glu Pro Gln Ser Leu Pro Pro Ser Asn Leu Ser Gly Ser Ser Glu 205 210 215 cag cag cct gac atc aac ctt gac ctg tcc cct ttg act ttg ggc tcc 3366 Gln Gln Pro Asp Ile Asn Leu Asp Leu Ser Pro Leu Thr Leu Gly Ser 220 225 230 cct cag aac cac acg tta caa gct cca ggc gag cca gcc cca cca tgg 3414 Pro Gln Asn His Thr Leu Gln Ala Pro Gly Glu Pro Ala Pro Pro Trp 235 240 245 gca gaa atg aga ggc ccc cac cca cca tgg aca gag gtg agg ggg ccc 3462 Ala Glu Met Arg Gly Pro His Pro Pro Trp Thr Glu Val Arg Gly Pro 250 255 260 265 cct ccc ggt atc gtc ccc gag aac ggg ctc gtg agg aga ctc aac acc 3510 Pro Pro Gly Ile Val Pro Glu Asn Gly Leu Val Arg Arg Leu Asn Thr 270 275 280 gtg ccc aac cta tcc cgg gtg atc tgg gtc aag aca ccc aag ccg ggc 3558 Val Pro Asn Leu Ser Arg Val Ile Trp Val Lys Thr Pro Lys Pro Gly 285 290 295 tac ccc agc tcc gag gag cca agc tca aag gaa gtt ccc agt tgc aag 3606 Tyr Pro Ser Ser Glu Glu Pro Ser Ser Lys Glu Val Pro Ser Cys Lys 300 305 310 cag gag ctg cct gag cct gtg tcc tca ggt ggg aag cca cag aag ggc 3654 Gln Glu Leu Pro Glu Pro Val Ser Ser Gly Gly Lys Pro Gln Lys Gly 315 320 325 aag agg cag ggc agt cag gcc aag aag agc gag gca agc cca gcc ccc 3702 Lys Arg Gln Gly Ser Gln Ala Lys Lys Ser Glu Ala Ser Pro Ala Pro 330 335 340 345 cgg ccc cca gcc agc cta gag gtt ccc agt gcc aag ggc cag gtc gct 3750 Arg Pro Pro Ala Ser Leu Glu Val Pro Ser Ala Lys Gly Gln Val Ala 350 355 360 ggc ccc aag cag cca ggc agg gtc cta gag ctt ccc aaa gta ggc agc 3798 Gly Pro Lys Gln Pro Gly Arg Val Leu Glu Leu Pro Lys Val Gly Ser 365 370 375 tgt gct gag gct gga gag ggg agc cgg ggg agc cgg cca gga cca ggt 3846 Cys Ala Glu Ala Gly Glu Gly Ser Arg Gly Ser Arg Pro Gly Pro Gly 380 385 390 tgg gct ggc agt ccc aaa act gag aag gag aag ggc agc tcc tgg cga 3894 Trp Ala Gly Ser Pros Thr Glu Lys Glu Lys Gly Ser Ser Trp Arg 395 400 405 aac tgg cca ggc gag gcc aag gca cgg cct cag gag cag gag tct gtg 3942 Asn Trp Pro Gly Glu Ala Lys Ala Arg Pro Gln Glu Gln Glu Ser Val 410 415 4 20 425 cag ccc cca ggc cca gca agg cca cag agc ttg ccc cag ggc aag ggc 3990 Gln Pro Pro Gly Pro Ala Arg Pro Gln Ser Leu Pro Gln Gly Lys Gly 430 435 440 cgc agc cgc cgg agc cgc aag aag cag gcc tcc tcc ttg 4038 Arg Ser Arg Arg Ser Arg Asn Lys Gln Glu Lys Pro Ala Ser Ser Leu 445 450 455 gac gat gtg ttc ctg ccc aag gac atg gac ggg gtg gag atg gat gag 4086 Asp Asp Val Phe Leu Pro Lys Asp Met Asp Gly Val Glu Met Asp Glu 460 465 470 act gac cga gag gtg gag tac ttt aag agg ttc tgt ttg gat tct gca 4134 Thr Asp Arg Glu Val Glu Tyr Phe Lys Arg Phe Cys Leu Asp Ser Ala 475 480 485 aag cag act cgt cag aaa gtt gct gtg aac tgg acc aac ttc agc ctc 4182 Lys Gln Thr Arg Gln Lys Val Ala Val Asn Trp Thr Asn Phe Ser Leu 490 495 500 505 aag aaa acc act cct agc aca gct cag tgaggccctg cccaggctga 4229 Lys Lys Lys Ser Thr Ala Gln 510 gctgcttcag ggcatcctga ggccctgact gccagctgaa ggcgtataat ttttccctcc 4289 gtgtgcccca cctacccgtc caagaccctc tgtgctcccc accatcctgg accaaccaaa 4349 agctgaacgg atgccaca ct gtgctggggc cccttgacct cagcagagcc gcttcctggt 4409 gctacgcagc ctccacactc agagcccgtg gactgggctg gcctaagggc cagggctgat 4469 ggtactgctg gcccaacact gctctctttg tgtttggttt ttttgttttt gtttttattt 4529 tgtttttttc caattcttta cttttgatac tgtgaagatc tttcgtgccg aaagataaag 4589 caacatttgg acacag 4605 <210> 131 <211> 4238 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (4063) <400> 131 c cca gat ttg gtc atg aca gta atg gaa gca atc tcc att ctt ttg aat 49 Pro Asp Leu Val Met Thr Val Met Glu Ala Ile Ser Ile Leu Leu Asn 1 5 10 15 gcc aag cct gat tgg cca tca gca aag caa ctt ctt ggt gac tct aac 97 Ala Lys Pro Asp Trp Pro Ser Ala Lys Gln Leu Leu Gly Asp Ser Asn 20 25 30 ttt cta aaa agg ctt tta gaa tat gat aag gag aac ata aag cct cag 145 Phe Leu Lys Arg Leu Leu Glu Tyr Asp Lys Glu Asn Ile Lys Pro Gln 35 40 45 ata ttg gca aag ctt caa aag tat att aat aat cct gat ttt gtg cct 193 Ile Leu Ala Lys Leu Gln Lys Tyr Ile Asn Asn Pro Asp Phe Val Pro 50 55 60 gaa aaa gtg gag aaa gtg tcc aaa gca tgt aaa tct atg tgc atg tgg 241 Glu Lys Val Glu Lys Val Ser Lys Ala Cys Lys Ser Met Cys Met Trp 65 70 75 80 gta aga gct atg gat ttg tac tct cga gtg gtc ag gtc gaa cca 289 Val Arg Ala Met Asp Leu Tyr Ser Arg Val Val Lys Val Val Glu Pro 85 90 95 aaa aga caa aag ctc cgc gcc gca cag gct gaa ctt gac att acc atg 337 Lys Arg Gln Lys Leu Arg Ala Ala Gln Ala Glu Leu Asp Ile Thr Met 100 105 110 gct acc ctg aga gaa aag caa gca tta cta aga caa gta gaa gat caa 385 Ala Thr Leu Arg Glu Lys Gln Ala Leu Leu Arg Gln Val Glu Asp Gln 115 120 125 ata cag gcc tta caa gat gaa tat gac aaa ggt gta ata gaa aaa gaa 433 Ile Gln Ala Leu Gln Asp Glu Tyr Asp Lys Gly Val Asn Glu Lys Glu 130 135 140 agc ctg gca aag acc atg gcc ctg aca aaa gca cgt cta gta cgt gct 481 Ser Leu Ala Lys Thr Met Ala Leu Thrs Ala Arg Leu Val Arg Ala 145 150 155 160 gga aag ctg aca gca gca tta gaa gat gag cag gtt cga tgg gaa gaa 529 Gly Lys Leu Thr Ala Ala Leu Glu Asp Glu Gln Val Arg Trp Glu Glu 165 170 175 agc ata cag ttt gag gaa gaa ata tca aat atc act ggg aac gtg 577 Ser Ile Gln Lys Phe Glu Glu Glu Ile Ser Asn Ile Thr Gly Asn Val 180 185 190 ttc ata gca gca gct tgt gtg gcc tac tat ggg gct ttc aca gcc cag 625 Ile Ala Ala Ala Cys Val Ala Tyr Tyr Gly Ala Phe Thr Ala Gln 195 200 205 tac agg cag tca ctt ata gag tgt tgg atc cag gac tgt cag tct ctg 673 Tyr Arg Gln Ser Leu Ile Glu Cys Trp Ile Gln Asp Cys Gln SerLeu 210 215 220 gag atc cca atc gat cct tcc ttc agt ctc att aac att ctt gga gat 721 Glu Ile Pro Ile Asp Pro Ser Phe Ser Leu Ile Asn Ile Leu Gly Asp 225 230 235 240 ccc tac gag ata cgg cag tgg aac act gat ggg ctg ccc cgt gac ttg 769 Pro Tyr Glu Ile Arg Gln Trp Asn Thr Asp Gly Leu Pro Arg Asp Leu 245 250 255 ata tca aca gaa aat ggc att ttg gtt act caa ggc aga aga tgg cct 817 Ile Ser Thr Glu Asn Gly Ile Leu Val Thr Gln Gly Arg Arg Trp Pro 260 265 270 ttg atg att gat ccc caa gat cag gca aac cgt tgg ata agg aac aag 865 Leu Met Ile Asp Pro Gln Asp Gln Ala Asn Arg Trp Ile Arg Asn Lys 275 280 285gaa agc aaa agt ggt tta aag atc att aag ctt aca gat agt aat ttc 913 Glu Ser Lys Ser Gly Leu Lys Ile Ile Lys Leu Thr Asp Ser Asn Phe 290 295 300 tta cga ata ctc gag aat tca atc cga ctt ggt tta cct gtc ctg 961 Leu Arg Ile Leu Glu Asn Ser Ile Arg Leu Gly Leu Pro Val Leu Leu 305 310 315 320 gaa gag ctt aag gaa acc ttg gat cca gct cta gaa ccc att ctt ttg 1009 Glu Glu Leu Lys Glu Thr Leu Asp Pro Ala Le Glu Pro Ile Leu Leu 325 330 335 aaa caa att ttt atc agt ggt ggc cga cta ctc atc cgt ctt gga gac 1057 Lys Gln Ile Phe Ile Ser Gly Gly Arg Leu Leu Ile Arg Leu Gly Asp 340 345 350 350 tca gac att gat tat gac aaa aac ttt agg ttc tat atg aca acc aaa 1105 Ser Asp Ile Asp Tyr Asp Lys Asn Phe Arg Phe Tyr Met Thr Thr Lys 355 360 365 atg cca aat ccc cac tat ctg cct gag gta tgc att aaa gtt acc att 1153 Met Pro Asn Pro His Tyr Leu Pro Glu Val Cys Ile Lys Val Thr Ile 370 375 380 atc aat ttc act gta aca aaa tca ggc ctg gag gat cag ttg tta agt 1201 Ile Asn Phe Thr Val Thr Lys Ser Gly Leu Glu Asp Gln Leu Leu Ser 385 390 395 400 gat gtg gtg cga ctt gaa aaa ccc agg ttg gaa gaa caa aga att aag 1249 Asp Val Val Arg Leu Glu Lys Pro Arg Leu Glu Glu Gln Arg Ile Lys 405 410 415 ctc atc gtg agg atc aac cag gaaa ttg aaa act atc gaa 1297 Leu Ile Val Arg Ile Asn Thr Asp Lys Asn Gln Leu Lys Thr Ile Glu 420 425 430 gag aaa atc ctg aga atg ctc ttt acc tct gaa gga aat att ctg gac 1345 Glu Lys Ile Leu Arg Met Leu Phe Thr Ser Glu Gly Asn Ile Leu Asp 435 440 445 aat gaa gaa ctt att gac aca ctc cag gat tca aag atc act tct ggt 1393 Asn Glu Glu Leu Ile Asp Thr Leu Gln Asp Ser Lys Ile Thr Ser Gly 450 455 460 gcc att aaa acc agg ctg gaa gaa gca gag tcc act gag cag atg atc 1441 Ala Ile Lys Thr Arg Leu Glu Glu Ala Glu Ser Thr Glu Gln Met Ile 465 470 475 475 aat gtg gct cgt gag aag tat cgt cca gtg gcc act ca tct gta 1489 Asn Val Ala Arg Glu Lys Tyr Arg Pro Val Ala Thr Gln Gly Ser Val 485 490 atg tac ttt gtc att gca agc ctc tca gaa ata gat cct atg tac cag 1537 Met Tyr Phe Val Ile Ala Ser Leu Ser Glu Ile Asp Pro Met Tyr Gln 500 505 510 tac tca tta aaa tac ttt aaa cag ttg ttc aat acc acc att gaa act 1585 Tyr Ser Leu Lys Tyr Phe Lys Gln Leu Phe Asn Thr Thr Ile Glu Thr 515 520 525 tct gta aag aca gaa aat cta caa cag cgc ctg gac gta cta cta gaa 1633 Ser Val Lys Thr Glu Asn Leu Gln Gln Arg Leu Asp Val Leu Leu Glu 530 535 540 caa act ctc cta act gct tat gtc aat gtt tca aga gga ctt ttt gag 1681 Gln Thr Leu Leu Thr Ala Tyr Val Asn Val Ser Arg Gly Leu Phe Glu 545 550 555 560 caa cat aaa ctc atc tac agc ttt atg ctt tgt gtt gag atg atg cgt 1729 Gln His Lys Leu Ile Tyr Ser Phe Met Leu Cys Val Glu Met Met Arg 565 570 575 cag caa gga acc cta tct gat gct gaa tgg aat ttc ttt ctc cga ggt 1777 Gln Gln Gly Thr Leu Ser Asp Ala Glu Trp Asn Phe Phe Leu Arg Gly 580 585 590 tct gca gga ttg gaacag ga cct aag cct gaa gct ccc tgg 1825 Ser Ala Gly Leu Glu Lys Glu Arg Pro Pro Lys Pro Glu Ala Pro Trp 595 600 605 cta cct act gct aca tgg ttc gca tgc tgt gac ttg gaa gaa tca ttt 1873 Leu Pro Thr Ala Thr Trp Phe Ala Cys Cys Asp Leu Glu Glu Ser Phe 610 615 620 cca gtt ttt cac gga ctt acc caa aat ata ttg tca cat cct att tcc 1921 Pro Val Phe His Gly Leu Thr Gln Asn Ile Leu Ser His Pro Ile Ser 625 630 635 640 ata cgc tta gga tct ttt gag act tat att aac cca cag aaa tgg gaa 1969 Ile Arg Leu Gly Ser Phe Glu Thr Tyr Ile Asn Pro Gln Lys Trp Glu 645 650 650 655 ggc tat tct aaa atg aaa cac gaa gat aaa cac atg a cag gaa aag 2017 Gly Tyr Ser Lys Met Lys His Glu Asp Lys His Met Arg Gln Glu Lys 660 665 670 gag gca gca cac caa gat cca tgg agt gca gga ttg agt tct ttc cat 2065 Glu Ala Ala His Gln Asp Pro Trp Ser Ala Gly Leu Ser Ser Phe His 675 680 685 aag cta att ctt att aaa tgt tgt aaa gaa gaa aag gtg gtt ttt gct 2113 Lys Leu Ile Leu Ile Lys Cys Cys Lys Glu Glu Glu Lys Val Val Phe Ala 690 695 700 ctt aca gactt gtg ata gaa aat ctt gga aaa cag ttt ata gag aca 2161 Leu Thr Asp Phe Val Ile Glu Asn Leu Gly Lys Gln Phe Ile Glu Thr 705 710 710 715 720 cca cct gtg gac ctg cct acc ctg tat caa gac atg tca tgc aact Pro Pro Val Asp Leu Pro Thr Leu Tyr Gln Asp Met Ser Cys Asn Thr 725 730 735 ccc ctg gta ttc atc cta agc aca ggc tca gat ccc atg ggt gca ttt 2257 Pro Leu Val Phe Ile Leu Ser Thr Gly Ser Asp Pro Met Gly Ala Phe 740 745 750 cag agg ttt gcc agg gaa agt gga tat tca gaa cgg gtg cag tca att 2305 Gln Arg Phe Ala Arg Glu Ser Gly Tyr Ser Glu Arg Val Gln Ser Ile 755 760 765 tca ctg ggg caa gga caa gcc t att gct gaa aaa atg gtc aag gat 2353 Ser Leu Gly Gln Gly Gln Gly Pro Ile Ala Glu Lys Met Val Lys Asp 770 775 780 780 gca atg aaa tca gga aac tgg gta ttt ttg caa aat tgc cat ctt gct 2401 Ala Met Lys Ser Gly Asn Trp Val Phe Leu Gln Asn Cys His Leu Ala 785 790 795 800 gtt tct tgg atg ttg gca atg gaa gag ctc att aaa acc ttc aca gat 2449 Val Ser Trp Met Leu Ala Met Glu Glu Leu Ile Lys Thr Phe Thr Asp 805 810 815 cca gat agt gct atc aag gac act ttt cga ctt ttt tta agc tcc atg 2497 Pro Asp Ser Ala Ile Lys Asp Thr Phe Arg Leu Phe Leu Ser Ser Met 820 825 830 cct agt aat aca ttt cct gtt aca gtt ctt caa aat tct gtc aag gtg 2545 Pro Ser Asn Thr Phe Pro Val Thr Val Leu Gln Asn Ser Val Lys Val 835 840 845 acc aat gag cct cca aaa ggc tta cgt gca aat atc aga cga gca ttt 2593 Thr Asn Glu Pro Pro Lys Gly Leu Arg Ala Asn Ile Arg Arg Ala Phe 850 855 860 act gaa atg aca cct tcg ttt ttt gaa gaa aat ata ctt gga aaa aaa 2641 Thr Glu Met Thr Pro Ser Phe Phe Glu Glu Asn Ile Leu Gly Lys Lys 865 870 870 875 880 tgg aga caa ata ata ttt ggc att tgt ttc ttc cat gca att att cag 2689 Trp Arg Gln Ile Ile Phe Gly Ile Cys Phe Phe His Ala Ile Ile Gln 885 890 895 gag aga aag aag ttt ggc ccc ctt ggt tgg tat atc tgtt 2737 Glu Arg Lys Lys Phe Gly Pro Leu Gly Trp Asn Ile Cys Tyr Glu Phe 900 905 910 aat gac agt gac agg gaa tgt gct tta ctg aat ctc aaa ctc tat tgt 2785 Asn Asp Ser Asp Arg Glu Cys Ala Leu Leu Asn Leu Tyr Cys 915 920 925 aaa gaa gga aag att ccc tgg gat gca cta att tac att act ggt gaa 2833 Lys Glu Gly Lys Ile Pro Trp Asp Ala Leu Ile Tyr Ile Thr Gly Glu 930 935 940 att act tat ggt ggt ga gtc gtc gac agc tgg gac caa aga tgc ctt 2881 Ile Thr Tyr Gly Gly Arg Val Thr Asp Ser Trp Asp Gln Arg Cys Leu 945 950 955 960 cgt act atc ttg aaa aga ttt ttt tct cct gaa aca tta gaa gaa gat 2929 Arg Thr I Lys Arg Phe Phe Ser Pro Glu Thr Leu Glu Glu Asp 965 970 975 tat aaa tac tct gaa tca ggc atc tat ttt gca ccc atg gct gac agc 2977 Tyr Lys Tyr Ser Glu Ser Gly Ile Tyr Phe Ala Pro Met Ala Asp Ser 980 985 990 cta caa gag ttt aag gac tac att gaa aat ctg cct ttg atc gat gac 3025 Leu Gln Glu Phe Lys Asp Tyr Ile Glu Asn Leu Pro Leu Ile Asp Asp 995 1000 1005 cca gaa att ttt gga atg cat gaat cta gtc ttc cag tac 3073 Pro Glu Ile Phe Gly Met His Glu Asn Ala Asn Leu Val Phe Gln Tyr 1010 1015 1020 aaa gag acc agc act tta atc aac acc ata ctt gag gtt cag cca agg 3121 Lys Glu Thr Ser Thr Leu Ile Asn Thr Ile Leu Glu Val Gln Pro Arg 1025 1030 1035 1040 tca tct act ggt gga gag gga aaa agc aat gac gaa att gtt caa gaa 3169 Ser Ser Thr Gly Gly Glu Gly Lys Ser Asn Asp Glu Ile Val Gln Glu 1045 1050 1055 ctt gtt gct tct gtc cag acc aga gtt cca gaa aaa ctg gaa atg gag 3217 Leu Val Ala Ser Val Gln Thr Arg Val Pro Glu Lys Leu Glu Met Glu 1060 1065 1070 ggt gct tct gag agc ctt ttt gtc aag gat ctt caa gga cgt g 3265 Gly Ala Ser Glu Ser Leu Phe Val Lys Asp Leu Gln Gly Arg Leu Asn 1075 1080 1085 tcc ttg acc acc gtt ctt gga cag gaa gtg gac cgg ttt aac aac ctg 3313 Ser Leu Thr Thr Val Leu Gly Gln Glu Val Asp Arg Phe Asn Asn Leu 1090 1095 1100 ctg aag tta att cat act tct ctg gaa aca ctc aac aaa gcc atc gct 3361 Leu Lys Leu Ile His Thr Ser Leu Glu Thr Leu Asn Lys Ala Ile Ala 1105 1110 1115 1120 gga ttt gtg gtg atg tct gaa gaa atg gaa aaa gtg tat aac agt ttc 3409 Gly Phe Val Val Met Ser Glu Glu Met Glu Lys Val Tyr Asn Ser Phe 1125 1130 1135 ctc aac aac cag gtt ccc gct ctg tgg tcc aacca tcc 3457 Leu Asn Asn Gln Val Pro Ala Leu Trp Ser Asn Thr Ala Tyr Pro Ser 1140 1145 1150 ctg aag cca cta gga tca tgg gtc aaa gac ctt atc ctg agg acc tca 3505 Leu Lys Pro Leu Gly Ser Trp Val Lys Asp Leu Ile Leu Arg Thr Ser 1155 1160 1165 ttt gtg gat ctg tgg ctc aaa aga gga cag cct aag tcc tac tgg atc 3553 Phe Val Asp Leu Trp Leu Lys Arg Gly Gln Pro Lys Ser Tyr Trp Ile 1170 1175 1180 tct ggt ttc ttc ttt ctt gga ttt cta aca gga act ctt caa aat 3601 Ser Gly Phe Phe Phe Pro Gln Gly Phe Leu Thr Gly Thr Leu Gln Asn 1185 1190 1195 1200 cat gct cga aaa tac aat ttg cct ata gat gag ctg a gt ttc aaa tac 3649 His Ala Arg Lys Tyr Asn Leu Pro Ile Asp Glu Leu Ser Phe Lys Tyr 1205 1210 1215 agc gta att ccc acc tat cgg gat caa gct gca gtg ata gaa gct gcc 3697 Ser Val Ile Pro Thr Tyr Arg Asp Gln Ala Ala Val Ile Glu Ala Ala 1220 1225 1230 aag aca gtg caa ttt gga caa gaa ctg ccc atg gac atg gag ttg ccc 3745 Lys Thr Val Gln Phe Gly Gln Glu Leu Pro Met Asp Met Glu Leu Pro 1235 1240 1245 tct cct gag ggt gtt ctt gtt cat ggg atg ttc atg gat gct tct 3793 Ser Pro Glu Asp Gly Val Leu Val His Gly Met Phe Met Asp Ala Ser 1250 1255 1260 cga tgg gat gat aag gag atg gtg ata gaa gat gca ttg ccc gga cag 3841g Trp Asp Asp Lys Glu Met Val Ile Glu Asp Ala Leu Pro Gly Gln 1265 1270 1275 1280 atg aat cca gtg ctg cct gtg gtg cat ttt gaa cca caa caa aac tat 3889 Met Asn Pro Val Leu Pro Val Val His Phe Glu Pro Gln Gln Asn Tyr 1285 1290 1295 aag cca agc cca aca ctt tac cac tgc cca ctt tat aaa aca gga gcc 3937 Lys Pro Ser Pro Thr Leu Tyr His Cys Pro Leu Tyr Lys Thr Gly Ala 1300 1305 1310 cgg gca gga aca ctc tca acc aca gga cat tca acc aat ttt gtg gta 3985 Arg Ala Gly Thr Leu Ser Thr Thr Gly His Ser Thr Asn Phe Val Val 1315 1320 1325 acc gtc ctg tta ccc tcc aag cgg tcc aaa gac tac tgg att gcc aag 4033 Thr Val Leu Leu Pro Ser Lys Arg Ser Lys Asp Tyr Trp Ile Ala Lys 1330 1335 1340 gga tca gct ttg ctc tgc cag ctg agc gaa tgaaaaggtg ccacctcagc 4083 Gly Ser Ala Leu Leu Cys Gln caggatgag agag 1350 gaataattta 4143 tatgtgagca aaacggtgtt aattctgatt tgacttaaac gtattgtgac ttttatttct 4203 cttatgacct taaaataaag tgtttgagtt ctttc 4238 <210> 132 <211> 2890 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2724) <400> 132 cct gct ggt gga cct ggt cta gag gat gtg gtt cag gaa gtg cag cag 48 Pro Ala Gly Gly Pro Gly Leu Glu Asp Val Val Gln Glu Val Gln Gln 1 5 10 15 gtg ctg tct gag ttt atc cgg gcc aac cca aag gcc tgg gca cct gtg 96 Val Leu Ser Glu Phe Ile Arg Ala Asn Pro Lys Ala Trp Ala Pro Val 20 25 30 att agt gca tgg tcc att gac ctc atg ggg caa ctg agc agc acg tac 144 Ile Ser Ala Trp Ser Ile Asp Leu Met Gly Gln Leu Ser Ser Thr Tyr 35 40 45 tca ggc cag cac cag cgt gtt ccc cac gct act ggc gct ctt aat gaa 192 Ser Gly Gln His Gln Arg Val Pro His Ala Thr Gly Ala Leu Asn Glu 50 55 60 ctg cta cag ctg tgg atg ggt tgt agg gcc acg cgt aca tta atg gac 240 Leu Leu Gln Leu Trp Met Gly Cys Arg Ala Thr Arg Thr Leu Met Asp 65 70 75 80 atc tat gtg cag tgc ctc tcg gct ctc att ggt agc tg gat gcg 288 Ile Tyr Val Gln Cys Leu Ser Ala Leu Ile Gly Ser Cys Pro Asp Ala 85 90 95 tgt gtg gat gcc ttg ctg gat acc tct gtt cag cat tct cca cac ttt 336 Cys Val Asp Ala Leu Leu Asp Thr Ser Val Gln His Ser Pro His Phe 100 105 11 0 gac tgg gtt gtg gca cat att ggc tcc tct ttt cct ggc acc atc att 384 Asp Trp Val Val Ala His Ile Gly Ser Ser Phe Pro Gly Thr Ile Ile 115 120 125 tcc cgg gtt ctc tcc tgt ggc ctt aag gac ttt tgt gtc gtc cat ggt ggg 432 Ser Arg Val Leu Ser Cys Gly Leu Lys Asp Phe Cys Val His Gly Gly 130 135 140 gct gga ggt gga gct ggc agt agt ggt gga agc tct tct cag acc ccc 480 Ala Gly Gly Gly Ala Gly Ser Ser Gly Gly Ser Ser Ser Gln Thr Pro 145 150 155 160 tct aca gac ccc ttc cct gga tct cct gcc att cct gcg gag aaa cgg 528 Ser Thr Asp Pro Phe Pro Gly Ser Pro Ala Ile Pro Ala Glu Lys Arg 165 170 175 gtg ccc aag att gcc tca gtt gta ggc atc cta ggt cac ctg gcc tcc 576 Val Pro Lys Ile Ala Ser Val Val Gly Ile Leu Gly His Leu Ala Ser 180 185 190 cgc cac gga gat agc atc cga cgg gag ctc ctg cga atg ttc cat gat 624g His Gly Asp Ser Ile Arg Arg Glu Leu Leu Arg Met Phe His Asp 195 200 205 agc ctg gca ggg gga tct gga ggc cgc agt ggg gac ccc tcc ctt cag 672 Ser Leu Ala Gly Gly Ser Gly Gly Gly Arg Ser Gly Asp Pro Ser Leu G ln 210 215 220 gcc acg gtt ccg ttc cta ctg cag ctg gca gtc atg tca cca gct ttg 720 Ala Thr Val Pro Phe Leu Leu Gln Leu Ala Val Met Ser Pro Ala Leu 225 230 235 240 ctg ggc act gtc tct gga gag cttgt gat tgc ctc aag ccc cca gct 768 Leu Gly Thr Val Ser Gly Glu Leu Val Asp Cys Leu Lys Pro Pro Ala 245 250 255 gtg ctg agc cag ctg cag caa cac ctt caa gga ttc ccc cga gag gag 816 Val Leu Ser Gln Leu Gln Gln His Leu Gln Gly Phe Pro Arg Glu Glu 260 265 270 ctg gac aac atg ttg aac ctg gct gtg cac ctg gtg agc cag gcc tct 864 Leu Asp Asn Met Leu Asn Leu Ala Val His Leu Val Ser Gln Ala Ser gg 280 280 285 gca ggt gcc tac cgc ttg ctg cag ttc ctg gtg gac aca gct atg 912 Gly Ala Gly Ala Tyr Arg Leu Leu Gln Phe Leu Val Asp Thr Ala Met 290 295 300 cct gct tcg gtc att acc acc cag ggc ctg gac gct gtg 960 Pro Ala Ser Val Ile Thr Thr Gln Gly Leu Ala Val Pro Asp Thr Val 305 310 315 320 cgt gag gct tgt gac cgg cta atc cag ctg ctg ctg ctg ctg cac ctg caa 1008 Arg Glu Ala Cys Asp Arg Leu Ile Gln Leu LeuLeu Leu His Leu Gln 325 330 335 aaa ctg gtt cat cac cgg gga ggg tct cct ggg gaa ggg gtg cta ggc 1056 Lys Leu Val His His Arg Gly Gly Ser Pro Gly Glu Gly Val Leu Gly 340 345 350 ccg ccc cca cct ccccc ttg gtg ccc ttt tta gat gcg ctc aaa aac 1104 Pro Pro Pro Pro Pro Arg Leu Val Pro Phe Leu Asp Ala Leu Lys Asn 355 360 365 cat gtt gga gag ctg tgt gga gag acg tta cga ttg gaa cgg aag cgc 1152 His Val Gly Glu Leu Cys Gly Glu Thr Leu Arg Leu Glu Arg Lys Arg 370 375 380 ttc ctc tgg cag cac cag ctc ttg ggc ctg ctg tct gtc tat acc cgg 1200 Phe Leu Trp Gln His Gln Leu Leu Gly Leu Leu Ser Val Tyr Thr 390 395 400 cct agc tgt gga cct gag gcc ttg ggc cat ctg ctg agc cga gcc cga 1248 Pro Ser Cys Gly Pro Glu Ala Leu Gly His Leu Leu Ser Arg Ala Arg 405 410 415 agc cct gaa gag ttg agt ttg gacc ca tat gca ggg cta gtg 1296 Ser Pro Glu Glu Leu Ser Leu Ala Thr Gln Leu Tyr Ala Gly Leu Val 420 425 430 gtc agc ctc tct ggc ctc ctg ccc ctg gct ttc cga agc tgt ctg gct 1344 Val Ser Leu Ser G Le eu Pro Leu Ala Phe Arg Ser Cys Leu Ala 435 440 445 cgg gtg cat gca ggg aca tta cag cct ccc ttc acg gcc cgg ttc ctg 1392 Arg Val His Ala Gly Thr Leu Gln Pro Pro Phe Thr Ala Arg Phe Leu 450 455 460 cgc aac ttg gca ctg cta gta ggg tgg gaa cag cag ggt ggc gag ggc 1440 Arg Asn Leu Ala Leu Leu Val Gly Trp Glu Gln Gln Gly Gly Glu Gly 465 470 475 480 480 cct gca gcc cta ggg gcg cac ttt ggg gca cat ctg 1488 Pro Ala Ala Leu Gly Ala His Phe Gly Glu Ser Ala Ser Ala His Leu 485 490 495 tct gac ctg gct cct ctc ctg cta cat cct gag gag gaa gta gct gaa 1536 Ser Asp Leu Ala Pro Leu Leu Leu His Pro Glu Glu Glu Val Ala Glu 500 505 510 gct gct gcc tct ctc ctg gcc att tgt ccc ttt cct tct gaa gcc tta 1584 Ala Ala Ala Ala Ser Leu Leu Ala Ile Cys Pro Phe Pro Ser Glu Ala Leu 515 520 525 tcc ccc tcc cag ctc gga ctg gta agg gct ggg gtg cac cgc ttc 1632 Ser Pro Ser Gln Leu Leu Gly Leu Val Arg Ala Gly Val His Arg Phe 530 535 540 ttt gcc tct ctg agg ctg cat gga ccc cca ggt gtg gcc tca gcc tgt 1680 Phe A la Ser Leu Arg Leu His Gly Pro Pro Gly Val Ala Ser Ala Cys 545 550 555 560 cag ctt ctc acc cgc ctg tct cag aca tcc cca gct ggg ctc aag gct 1728 Gln Leu Leu Thr Arg Leu Ser Gln Thr Ser Pro Ala Gly Leu Lys Ala 565 570 575 gtc ctg cag ctg ctg gtt gaa gga gcc tta cat cga ggc aac aca gaa 1776 Val Leu Gln Leu Leu Val Glu Gly Ala Leu His Arg Gly Asn Thr Glu 580 585 590 590 ctg ttt ggt ggg ga g g aat gag act ctc tca gtt gtt 1824 Leu Phe Gly Gly Gln Val Asp Gly Asp Asn Glu Thr Leu Ser Val Val 595 600 605 tca gct tct ttg gct tct gcc tcc ctg ttg gac act aac cgg agg cac 1872 Ser Ala Ser Leu Ala Ser Ala Ser Leu Leu Asp Thr Asn Arg Arg His 610 615 620 act gca gct gtg cca ggt cct gga ggg att tgg tca gtt ttc cat gct 1920 Thr Ala Ala Val Pro Gly Pro Gly Gly Ile Trp Ser Val Phe His Ala 625 630 635 640 gga gtc atc ggc cgt ggc tta aag cca ccc aag ttt gtc cag tca cga 1968 Gly Val Ile Gly Arg Gly Leu Lys Pro Pro Lys Phe Val Gln Ser Arg 645 650 655 aat cag cag gaa gtg atc tat aac acc cag agccc agc ctc ctg 2016 Asn Gln Gln Glu Val Ile Tyr Asn Thr Gln Ser Leu Leu Ser Leu Leu 660 665 670 gtt cac tgc tgc agt gcc cca ggg ggc act gaa tgt ggg gaa tgc tgg 2064 Val His Cys Cys Ser Ala Pro Gly Thr Glu Cys Gly Glu Cys Trp 675 680 685 ggg gca ccc atc ttg agt cca gag gca gcc aaa gca gtg gca gtg acc 2112 Gly Ala Pro Ile Leu Ser Pro Glu Ala Ala Lys Ala Val Ala Val Thr 690 695 700 ttg gtg gag agt gt tgt ccc gat gca gct ggt gca gag ctg gcc tgg 2160 Leu Val Glu Ser Val Cys Pro Asp Ala Ala Gly Ala Glu Leu Ala Trp 705 710 715 720 ccc ccc gag gaa cac gcc cgg gcc acc gtg gag cgg gat ctc cgc att 2208 Pro Glu Glu His Ala Arg Ala Thr Val Glu Arg Asp Leu Arg Ile 725 730 735 ggc cgg cgc ttc cgc gaa cag ccc ctg ctc ttt gag ctg tta aag ctg 2256 Gly Arg Arg Phe Arg Glu Gln Pro Leu Leu Phe Glu Leu 740 745 750 gta gca gct gca ccc cca gcc ctg tgc tac tgt tcc gtg ctg ctt cgg 2304 Val Ala Ala Ala Pro Pro Ala Leu Cys Tyr Cys Ser Val Leu Leu Arg 755 760 765 ggg ctg ctg gcc gcc ctc ttg cat tgg gaa gcc tct cgc cac cct 2352 Gly Leu Leu Ala Ala Leu Leu Gly His Trp Glu Ala Ser Arg His Pro 770 775 780 gac acg acc cac tcc ccc tgg cac ctg gag gca tcc tgc acc tta gtg 2400 Asp Thr Thr His Ser Pro Trp His Leu Glu Ala Ser Cys Thr Leu Val 785 790 795 800 gct gtc atg gct gag gga agc ctc ctg cct ccg gcc ctg ggt aat atg 2448 Ala Val Met Ala Glu Gly Ser Leu Leu Pro Pro Ala Leu Gly Asn Met 805 810 815 cat gaa gta ttt agc caa ctg gca cct ttc gag gtg cgt ctg ctg ctg 2496 His Glu Val Phe Ser Gln Leu Ala Pro Phe Glu Val Arg Leu Leu Leu 820 825 830 ctc agt gtc tgg ggt ttt ctc cgg gtt cct cag aag 2544 Leu Ser Val Trp Gly Phe Leu Arg Glu His Gly Pro Leu Pro Gln Lys 835 840 845 ttc atc ttc caa tca gag cgg ggt cgc ttc att cgg gac ttc tcc agg 2592 Phe Ile Phe Gln Ser Glu Arg Gly Arg Ile Arg Asp Phe Ser Arg 850 855 860 gag ggt gga ggt gag ggt gga ccc cat ctg gct gtg ctg cac agt gtc 2640 Glu Gly Gly Gly Gly Glu Gly Gly Pro His Leu Ala Val Leu His Ser Val 865 870 875 880 880 ctc cac c gc aac atc gac cgc cta ggt ctt ttc tct ggc cgt ttc cag 2688 Leu His Arg Asn Ile Asp Arg Leu Gly Leu Phe Ser Gly Arg Phe Gln 885 890 895 gca cct tca ccg tcc act ctc ctt cga cag ggg acg tagcc Ser Pro Ser Thr Leu Leu Arg Gln Gly Thr 900 900 <210> 133 <211> 4902 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2294) .. (4021) <400> 133 gatactttaa atggttccga catcctaaat aaaatataac acatgtcctt atgtagttaa 60 taaaatccat ataacacact cctcaacctg aagttggagc actgcacaag tttatgtaat 120 tactacatag cccatttttt catttgcttt tctagtgttg ctaaggtact tcgaatgaag 180 tattcaaacc aaaccttttt tttttttttt ttttttttgg ctaaaggtgt atttgaaaaa 240 aatgataaac agtgttacca tgaacttaaa ttaaccagaa tgctcatgaa atttactttt 300 cttttttttc ggtagggcca ggggttggga tgaggagtca ggattttcat gttgaggaca 360 aaatagcaac cttttcaatt ctatgaaggc gttttttgtt tgtttaagga aaaattttgt 420 tttcttatgc ttttattctg tcataaaagc aatgtgtggg gagaggttta aggatttggt 480 tagttgatgt ctaatgaata tctttattga ataacttgat aaaagatttc aagaaaaatt 540 tcggtggtac taaaagtaga aataccacaa aaatctgatt gatatgtata atatatttat 600 atggctataa aggatatatc gctctaaagt tgtaactaca gtagacattt ttctctatta 660 tgatatgcta actgatgtaa aaataaatct gcaataagat tccccaaata aaaatagtat 720 atcaatatcc taaagattta ctataaatta gtaagttttc actttaatat actaatgttt 780 ttttctgttg actctgagat atagggtaca tttgatattt taatctagat gaaacactgt 840 ctgctagtta tattcagatt ctgtaatcta gtaaagctgt tttgcattta actttaaata 900 ttaagcaaac tacggctggg cgtggtggct cacgcctata atcccagcac tttgggaggc 960 caagatggga ggatcacttg aggtcaggag ttccagacca gcctggccaa catggtgaaa 1020 ccccgtctct attaaaaata caaaaatcag ccaggcatga tggtgcacgt ataatcccag 1080 ctactctgga ggctgaggca aaagaatcac ttgaaccctg gaggcagagg ttgcaatgag 1140 ccgagatcgc accactgcac tccaggctgg gcaataacga gactccatct caaaaaataa 1200 ataaatatta agcaaactat atttgaacat cttagtagct tatgactttt catctttaat 1260 ttgttataaa tatgaaaatg gaattttggc attgtcttac tttttttatc atagatctac 1320 ctatttaaaa cttacttcat attacttttt ttccagatag gaatataaat tattttcttg 1380 gatctaggtg ctttaattta caatgacagt tgacacttct caggacacac ctgaggatac 1440 ttattttgaa tagtataaga gtattctaac ttttgtcatt aaattcattt ttcatgtaat 1500 attcattcct atgaaagttt tgtggtttaa caatcactgc atacccttaa atagtcacag 1560 attcatttgc atgaggtatg tgaaagtaat gtcttgaaat gaaatataaa tccaggattt 1620 attgtatgtt tggaatgctt atatttttaa ccttctcctg attcccacat ttctagatca 1680 attcaaagtt atctcct gtt taaatgatgc ttccttttaa agctgtaact gtcaagcagt 1740 ttctttcata gagaaaacat atagaattgt catttataca ttcttatgta ttatgcgtat 1800 atgaaattta attttttaaa ctggaatgta attgggacac attacttcta accccacctt 1860 gaaaacattg tgccatttag taaacatgca atgagcccca tttaaatttt ttctactgtg 1920 tttttgttat tttctcacag tcaatataaa aatcaaaaga caagaaaaat agtgaagtat 1980 tgcctgcaga ggctgtgatg ttatctgtgg tataactgac tgggatggct attgaaatct 2040 tgctaagcac aatcagaagt aaccaaaata tcttttaacc aaaatgtact gggcagaagc 2100 tgaagaaagg atatttaagt acactgaata attccttaca atatagtaac ataaatggag 2160 tcaactaaca cacataaact ttttatgaaa tttgactatc catagtttat aacataggct 2220 ttcagtttta taagatttcg aatgattttc ctcttttcaa ttaaacccat ccttttcctt 2280 cattatcttt tag ttc tta aga cag aag agc aag ata agt cta tat tgt 2329 Phe Leu Arg Gln Lys Ser Lys Ile Ser Leu Tyr Cys 1 5 10 ctg tca caa gat gaa ggt aga ggc aca tta tac aaa tac aga cct gaa 2377 Leu Ser Gln Asp Glu Gly Arg Gly Thr Leu Tyr Lys Tyr Arg Pro Glu 15 20 25 gaa gta gat att gat gcc aag tta agc cga tt a tgt gaa caa gat aaa 2425 Glu Val Asp Ile Asp Ala Lys Leu Ser Arg Leu Cys Glu Gln Asp Lys 30 35 40 gtg gtg cat gct ctg gaa gag aaa ctt cag caa ctc cac aag gag aaa 2473 Val Val His Ala Leu Glu Glu Lys Leu Gln Gln Leu His Lys Glu Lys 45 50 55 60 tac acg ctt gag caa gct ttg cta tca gcc agc caa gag ata gaa atg 2521 Tyr Thr Leu Glu Gln Ala Leu Leu Ser Ala Ser Gln Glu Ile Glu Met 65 70 75 cat gca gat aac cca gca gcc att cag aca gtg gtg tta caa agg gat 2569 His Ala Asp Asn Pro Ala Ala Ile Gln Thr Val Val Leu Gln Arg Asp 80 85 90 gat tta caa aat gga ctg ctt agt acg tgt cga gaa ctt tct cga gcc 2617 Asp Leu Gln Asn Gly Leu Leu Ser Thr Cys Arg Glu Leu Ser Arg Ala 95 100 105 act gcc gaa ttg gaa cga gca tgg aga gaa tat gat aag tta gaa tac 2665 Thr Ala Glu Leu Glu Arg Ala Trp Arg Glu Tyr Asp Lys Leu Glu Tyr 110 115 120 gat gta act gtt acc agg aac cag atg caa gag cag ctg gat cac ctt 2713 Asp Val Thr Val Thr Arg Asn Gln Met Gln Glu Gln Leu Asp His Leu 125 130 135 140 ggt gaa gtt cag acg gaa tca gca g ga att cag cgt gca cag att cag 2761 Gly Glu Val Gln Thr Glu Ser Ala Gly Ile Gln Arg Ala Gln Ile Gln 145 150 155 aaa gaa ctt tgg cga att cag gat gtc atg gaa ggg ctg agt aaa cat 2809 Lys Glu Leu Trp Ile Gln Asp Val Met Glu Gly Leu Ser Lys His 160 165 170 aag cag caa aga ggt act aca gaa ata ggt atg ata gga tca aag cct 2857 Lys Gln Gln Arg Gly Thr Thr Glu Ile Gly Met Ile Gly Ser Lys Pro 175 180 185 ttc tca aca gtt aag tac aaa aat gag gaa gag gaa gta gtc cca cct 2905 Phe Ser Thr Val Lys Tyr Lys Asn Glu Glu Glu Glu Val Val Pro Pro 190 195 200 cgt cct cca ctt cct cgg tcc tat gac ttt aca gag cag cct ccc ata 2953 Arg Pro Pro Leu Pro Arg Ser Tyr Asp Phe Thr Glu Gln Pro Pro Ile 205 210 215 220 atc ccc cct ctg ccc agt gat agc agc tcc ttg ctc tgt tat agc agg 3001 Ile Pro Pro Leu Pro Ser Asp Ser Ser Ser Leu Leu Cys Tyr Ser Arg 225 230 235 ggc cca gtt cat ctg cct gaa gaa aag aag atg tat caa gtt caa gga 3049 Gly Pro Val His Leu Pro Glu Glu Lys Lys Met Tyr Gln Val Gln Gly 240 245 250 tat cca aga aa t gga tct cac tgt ggt cca gat tat aga ctc tac aag 3097 Tyr Pro Arg Asn Gly Ser His Cys Gly Pro Asp Tyr Arg Leu Tyr Lys 255 260 265 agt gaa cca gag tta aca aca gtg gca gaa gtt gat gaa tct aat gga 145 Ser Glu Pro Glu Leu Thr Thr Val Ala Glu Val Asp Glu Ser Asn Gly 270 275 280 gaa gaa aaa tca gaa cct gtt tca gag ata gaa act tca gtt gtt aaa 3193 Glu Glu Lys Ser Glu Pro Val Ser Glu Ile Glu Thr Ser Val Val Lys 285 290 295 300 ggt tcc cac ttt cct gtt gga gta gtc cct cca aga gca aaa tca cca 3241 Gly Ser His Phe Pro Val Gly Val Val Pro Pro Arg Ala Lys Ser Pro 305 310 315 aca ccc gaa tct tcg aca ata gct tcc tat gta acc ttg agg aaa act 3289 Thr Pro Glu Ser Ser Thr Ile Ala Ser Tyr Val Thr Leu Arg Lys Thr 320 325 330 aag aag atg atg gat cta aga acg gaa aga cca aga agt gca gtg gaa 3337 Lys Lys Met Met Asp Leu Arg Thr Glu Arg Pro Arg Ser Ala Val Glu 335 340 345 cag ctc tgt ttg gct gaa agt act cga cca agg atg act gtg gaa gag 3385 Gln Leu Cys Leu Ala Glu Ser Thr Arg Pro Arg Met Thr Val Glu Glu 350 355 360 caa atg gaa aga ata aga aga cat caa caa gcg tgc ctg agg gag aag 3433 Gln Met Glu Arg Ile Arg Arg His Gln Gln Ala Cys Leu Arg Glu Lys 365 370 375 380 380 aaa aaa ggg tta aat gtt atc ggt gct tca g tca ccc tta caa 3481 Lys Lys Gly Leu Asn Val Ile Gly Ala Ser Asp Gln Ser Pro Leu Gln 385 390 395 agc cct tca aat tta agg gat aat cca ttt agg act act cag act cga 3529 Ser Pro Ser Asn Leu Arg Asp Asn Pro Phe Arg Thr Thr Gln Thr Arg 400 405 410 agg agg gat gat aag gaa ctg gac act gcc att aga gaa aat gat gta 3577 Arg Arg Asp Asp Lys Glu Leu Asp Thr Ala Ile Arg Glu Asn Asp Val 415 420 425 aag cca gac cat gaa act cct gca aca gaa att gtt caa cta aaa gaa 3625 Lys Pro Asp His Glu Thr Pro Ala Thr Glu Ile Val Gln Leu Lys Glu 430 435 440 acc gaa ccc caa aat gtg gac ttc agc aaa gag tta aaa aaa act gaa 3673 Glu Pro Gln Asn Val Asp Phe Ser Lys Glu Leu Lys Lys Thr Glu 445 450 455 460 aac att tca tat gaa atg ctt ttt gaa cct gag cca aat gga gta aat 3721 Asn Ile Ser Tyr Glu Met Leu Phe Glu Pro Glu Pro Asn Gly Val Asn 465 470 475 tct gtg gaa atg atg gat aaa gaa aga aac aaa gac aaa atg cct gag 3769 Ser Val Glu Met Met Asp Lys Glu Arg Asn Lys Asp Lys Met Pro Glu 480 485 490 490 gat gtt aca ttc ac cc gat gaa aca cag acc gca aat cat aaa 3817 Asp Val Thr Phe Ser Pro Gln Asp Glu Thr Gln Thr Ala Asn His Lys 495 500 505 cca gaa gag cat cct gaa gaa aat aca aag aac agt gtt gac gaa cag 3865 Pro Glu Glu His Pro Glu Glu Asn Thr Lys Asn Ser Val Asp Glu Gln 510 515 520 gaa gaa act gtt att tct tac gaa tca act cct gag gtt tct aga gga 3913 Glu Glu Thr Val Val Ile Ser Tyr Glu Ser Thr Pro Glu Val Ser Arg Gly 525 530 535 540 aat caa aca atg gca gtg aaa agt ctg tcc cca tct cct gag tcc tcg 3961 Asn Gln Thr Met Ala Val Lys Ser Leu Ser Pro Ser Pro Glu Ser Ser 545 550 555 gca tcg cca gtt cca tcc act cag ccg cag ctc aca gaa gga tca cat 4009 Ala Ser Pro Val Pro Ser Thr Gln Pro Gln Leu Thr Glu Gly Ser His 560 565 570 ttc atg tgt gtg tagtcttaga agaactatac tgacttctgt tgaaaccatt 4061 Phe Met Cys Val 575 caaagctaaa g acatggacc ttcagcagtg taagaagata ttgtacagta tattttaaat 4121 ctatgaaatt catagttctg atgcttttgg tcacagagca tcattttatc acttctggaa 4181 aatgtttatt ccaaaacagc tttaatggcc catatgtaca cttcgtaatc tcaaggttat 4241 tattctgaca ccagcttgct gctatgattt cagagcacat aagtaaaggt gctttttaat 4301 gtgcagtcta tttccagagc ttacttagtt gctgatttcc agatttcgat gtttcttaag 4361 tctaggtgaa tttatatata tatttttttg cttttcattt tctaaagtta gttattattt 4421 ccattgaagc ttgttttctt ttttttcttc ccattttagc tactgcagtg cttttgtttc 4481 acacttgatt tgtaaaaatt ttatatatat gtatttaaaa tgtgccattt tattgctaag 4541 tgaagtatgt cctgttttct gctataattc tttctcggtc agattgcaat gtcagcagtt 4601 actgccacac tcctgtcagc ttaaacacaa atgttactgc ttatcttttc ttaaaaaaaa 4661 aaaaaacaaa gtgtaggtat tttgaagtac tgggcttata tttcattgga atacatgtgt 4721 acagcaataa gcaggtttcc aaatccggta cttagtttgt gtacaaatgt aattatgttc 4781 attgtgtata tattatacaa tgagcacatg taatgtatta aaggctactt actattgttt 4841 aaatgcaaat gttcatatct catttctttt tttatcatgt taaataaatg ttgatgttct 4901 t 4902 <210> 134 <211> 4132 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2899) <400> 134 g aaa tac aga agc aca gtc agc aaa agc aaa gac ccc tcg ggg ctg ctc 49 Lys Tyr Arg Ser Thr Val Ser Lys Ser Lys Asp Pro Ser Gly Leu Leu 1 5 10 15 atc tct gtg atc agg act ctg tct act agt gac gat gtc gaa gac agg 97 Ile Ser Val Ile Arg Thr Leu Ser Thr Ser Asp Asp Val Glu Asp Arg 20 25 30 gaa aat gaa aag ggt cgc ctt gaa gaa gcc tac gag aaa tgt gac cgt 145 Glu Asn Glu Lys Gly Arg Leu Glu Glu Ala Tyr Glu Lys Cys Asp Arg 35 40 45 gac ctg gat gaa ttg att gta cag cac tac aca gaa ttg acg aca gcc 193 Asp Leu Asp Glu Leu Ile Val Gln His Tyr Thr Glu Leu Thr Thr Ala 50 55 60 att cgc aca tac cag agc atc aca gag cgc atc act aac tcc cga aat 241 Ile Arg Thr Tyr Gln Ser Ile Thr Glu Arg Ile Thr Asn Ser Arg Asn 65 70 75 80 aaa ata aag cag gta aaa gag aac ctg ctt tca tgc aag atg ctg ctg 289 Lys Ile Lys Gln Val Lys Glu Asn Leu Leu Ser Cys Lys Met Leu Leu 85 90 95 cac tgc aaa cgg gat gag ctt cgg aaa ctg tgg att gaa gga att gag 337 His Cys Lys Arg Asp Glu Leu Arg Lys Trp Ile Glu Gly Ile Glu 100 105 110 cat aag cat gtc ctg aac ttg ttg gat gaa att gag aat atc aag caa 385 His Lys His Val Leu Asn Leu Leu Asp Glu Ile Glu Asn Ile Lys Gln 115 120 125 gtg cct caa aag ctg gaa cag tgc atg gcc ag ag tat ctc agt 433 Val Pro Gln Lys Leu Glu Gln Cys Met Ala Ser Lys His Tyr Leu Ser 130 135 140 gcc act gac atg ttg gtg tca gca gtt gag tct ttg gag ggc ccc ctg 481 Ala Thr Asp Met Leu Val Ser Ala Val Glu Ser Leu Glu Gly Pro Leu 145 150 155 160 ctc cag gtg gaa gga ctg agt gac ctt cga cta gag ctt cac agc aag 529 Leu Gln Val Glu Gly Leu Ser Asp Leu Arg Leu Glu Leu His Ser Lys 165 170 175 aag atg aac ctt cac ttg gtt ctc ata gat gaa cta cac cgg cac ctg 577 Lys Met Asn Leu His Leu Val Leu Ile Asp Glu Leu His Arg His Leu 180 185 190 tac atc aaa tcg act agc cga gtt gtg cag cgt aac aag gaa aaa ggg Ile Lys Ser Thr Ser Arg Val Val Gln Arg Asn Lys Glu Lys Gly 195 200 205 aaa atc agc tcc ctc gtg aaa gat gct tct gtt cct ctg att gat gtt 673 Lys Ile Ser Ser Leu Val Lys Asp Ala Ser Val Pro Leu Ile Asp Val 210 215 220 aca aac ctc cct act cct cga aaa ttc ctt gat acc tct cac tat tct 721 Thr Asn Leu Pro Thr Pro Arg Lys Phe Leu Asp Thr Ser His Tyr Ser 225 230 235 240 act gct gga agc tca agt gtg agg gag ata aat ctg cag gac atc aag 769 Thr Ala Gly Ser Ser Ser Val Arg Glu Ile Asn Leu Gln Asp Ile Lys 245 250 255 gaa gat tta gaa ttg gat cca gag gaa aac agc acc ctg ttt atg ggt 817 Glu Asp Leu Glu Leu Pro Glu Glu Asn Ser Thr Leu Phe Met Gly 260 265 270 atc ctc att aag ggc ttg gcg aaa ctg aag aag atc cca gaa aca gtt 865 Ile Leu Ile Lys Gly Leu Ala Lys Leu Lys Lys Ile Pro Glu Thr ag 275 280 285 gca atc ata gag cgc ttg gag cag gag ttg aag caa att gtg aag 913 Lys Ala Ile Ile Glu Arg Leu Glu Gln Glu Leu Lys Gln Ile Val Lys 290 295 300 agg tct aca acc cag gtg gca gac agt ggc gg cag aac 961 Arg Ser Thr Thr Gln Val Ala Asp Ser Gly Tyr Gln Arg Gly Glu Asn 305 310 315 320 gtt act gtg gag aac caa cca agg ttg ctt cta gaa ctg ctg gag tta 1009 Val Thr Val Glu Asn Gln Pro Arg Leu Leu Leu Le u Glu Leu Leu Glu Leu 325 330 335 ctg ttt gac aag ttt aat gct gta gcc gct gca cac tct gtg gtc ctg 1057 Leu Phe Asp Lys Phe Asn Ala Val Ala Ala Ala His Ser Val Val Leu 340 345 350 350 gga tac ctg cag gac act gta gtg act cca ctg act cag cag gaa gat 1105 Gly Tyr Leu Gln Asp Thr Val Val Thr Pro Leu Thr Gln Gln Glu Asp 355 360 365 atc aaa ctg tat gat atg gca gat gta tgg gtg aag atc caa gat gtt 1153 Ile Lys Leu Tyr Asp Met Ala Asp Val Trp Val Lys Ile Gln Asp Val 370 375 380 cta cag atg cta tta act gag tac ttg gat atg aaa aat act cgt acg 1201 Leu Gln Met Leu Leu Thr Glu Tyr Leu Asp Met Lys Asn Thr Arg Thr 385 390 395 400 gcc tct gaa cca tca gct caa cta agc tat gcc agc act gga cga gag 1249 Ala Ser Glu Pro Ser Ala Gln Leu Ser Tyr Ala Ser Thr Gly Arg Glu 405 410 415 ttt gca gcc ttt ttt gcc aag aag aaa cct caa agg cca aaa aat tct 1297 Phe Ala Ala Phe Phe Ala Lys Lys Lys Pro Gln Arg Pro Lys Asn Ser 420 425 430 ctt ttc aag ttc gaa tcg tcc tcc cat gcc atc agt atg agc gcc tat 1345 Leu Phe Lys Phe Glu Ser Ser Ser His Ala Ile Ser Met Ser Ala Tyr 435 440 445 ctg cga gaa cag aga agg gag ctc tat agt cgg agt gga gaa ctg caa 1393 Leu Arg Glu Gln Arg Arg Glu Leu Tyr Ser Arg Ser Gly Glu Leu Gln 450 455 460 ggg ggt cct gat gac aac tta att gaa ggt gga gga aca aaa ttt gtc 1441 Gly Gly Pro Asp Asp Asn Leu Ile Glu Gly Gly Gly Thr Lys Phe Val 465 470 475 475 480 tgc aaa cct gga gcc aga aac att acc gtc atacac c tta cta 1489 Cys Lys Pro Gly Ala Arg Asn Ile Thr Val Ile Phe His Pro Leu Leu 485 490 495 aga ttt att cag gag att gag cat gct ctg ggt ctt ggc cca gcc aaa 1537 Arg Phe Ile Gln Glu Ile Glu His Ala Leu Gly Leu Gly Pro Ala Lys 500 505 510 cag tgt cct ctt cga gag ttt ctc acc gtg tac atc aaa aac atc ttt 1585 Gln Cys Pro Leu Arg Glu Phe Leu Thr Val Tyr Ile Lys Asn Ile Phe 515 520 525 ctc aat caa gtc ttg gag atc aac aag gag att gaa gga gtc act 1633 Leu Asn Gln Val Leu Ala Glu Ile Asn Lys Glu Ile Glu Gly Val Thr 530 535 540 aaa aca tct gac cct ttg aag att ctg gcc aac gca gac acc atg aag 1681 Lys Thr Ser Asp Pro Leu Lys Ile Leu Ala Asn Ala Asp Thr Met Lys 545 550 555 560 gtg ctg gga gtg cag cgg cct ctc cta cag agc aca atc att gtg gag 1729 Val Leu Gly Val Gln Arg Pro Leu Leu Gln Ser Thr Ile Val Glu 565 570 575 aag aca gtt caa gac ctc ctg aac ctg atg cat gac ttg agt gca tat 1777 Lys Thr Val Gln Asp Leu Leu Asn Leu Met His Asp Leu Ser Ala Tyr 580 585 590 tca gat caa ttc ctc ag atg gtc gta aag ctc cag gag tac aag 1825 Ser Asp Gln Phe Leu Asn Met Val Cys Val Lys Leu Gln Glu Tyr Lys 595 600 605 gac acc tgc act gca gct tac agg ggt att gtc cag tca gaa gaa aaa 1873 Asp Thr Cys Thr Ala Tyr Arg Gly Ile Val Gln Ser Glu Glu Lys 610 615 620 ctt gtc atc agt gca tcc tgg gca aaa gat gat gat atc agc aga ctc 1921 Leu Val Ile Ser Ala Ser Trp Ala Lys Asp Asp Asp Ile Ser Arg Leu 625 630 635 640 ttg aaa tct cta cca aac tgg atg aat atg gct caa ccc aaa cag ctg 1969 Leu Lys Ser Leu Pro Asn Trp Met Asn Met Ala Gln Pro Lys Gln Leu 645 650 655 agg cca aaa aga gag gag gaa gaa gat ttc ata agg ca gct ttt ggc 2017 Arg Pro Lys Arg Glu Glu Glu Glu Asp Phe Ile Arg Ala Ala Phe Gly 660 665 670 aag gag tct gaa gtt ctt att ggg aac ctg ggt gat aaa tta atc cct 2065 Lys Glu Ser Glu Val Leu Ile Gn Leu Gly Asp Lys Leu Ile Pro 675 680 685 cca caa gac atc ctt cgt gac gtc agt gac ctc aaa gcc ttg gcc aac 2113 Pro Gln Asp Ile Leu Arg Asp Val Ser Asp Leu Lys Ala Leu Ala Asn 690 695 700 atc cat gaa ag ctg gaa tgg ttg gca agt cga aca aag tca gct ttc 2161 Met His Glu Ser Leu Glu Trp Leu Ala Ser Arg Thr Lys Ser Ala Phe 705 710 715 720 tcc aat ctt tct aca tcc cag atg ctt tct cct gct caa gac agc cac Ser Asn Leu Ser Thr Ser Gln Met Leu Ser Pro Ala Gln Asp Ser His 725 730 735 acg aac acg gat ctc ccc cca gtg tca gag cag atc atg cag act ctc 2257 Thr Asn Thr Asp Leu Pro Pro Val Ser Glu Gln Ile Met Gln Thr Leu 740 745 750 agt gaa ctt gcc aaa tcg ttc cag gat atg gct gac cgc tgc ttg ctt 2305 Ser Glu Leu Ala Lys Ser Phe Gln Asp Met Ala Asp Arg Cys Leu Leu 755 760 765 gtc gg gt cat gtg gaa t cac tgt ttc cac tat ctt atc cct 2353 Val Leu His Leu Glu Val Arg Val His Cys Phe His Tyr Leu Ile Pro 770 775 780 ctt gca aag gag ggg aac tat gcc att gtg gct aat gtg gaa agt atg 2401 Leu Ala Lys Glu Gly Asn Tyr Ala Ile Val Ala Asn Val Glu Ser Met 785 790 795 800 gat tat gac ccc ctg gtg gtc aag ctc aac aaa gat atc agc gcc att 2449 Asp Tyr Asp Pro Leu Val Val Lys Leu Asn Lys Asp Ile Ser Ala Ile 805 810 815 gaa gag gcc atg agc gcc agc ctt cag cag cac aag ttc cag tat atc 2497 Glu Glu Ala Met Ser Ala Ser Leu Gln Gln His Lys Phe Gln Tyr Ile 820 825 830 ttc gaa ggc ctg ggc tc atc tc atg atc tc atg att aat ggt gcc 2545 Phe Glu Gly Leu Gly His Leu Ile Ser Cys Ile Leu Ile Asn Gly Ala 835 840 845 cag tac ttc agg cgc atc agt gag tct ggc atc aag aaa atg tgt agg 2593 Gln Tyr Phe Arg Arg Ile Glu Ser Gly Ile Lys Lys Met Cys Arg 850 855 860 aac att ttt gtt ctt cag cag aat ttg acc aac atc acc atg tcg cgg 2641 Asn Ile Phe Val Leu Gln Gln Asn Leu Thr Asn Ile Thr Met Ser Arg 865 870 875 875 880 gag gc a gac ctg gac ttt gca agg cag tac tac gag atg ctt tac aac 2689 Glu Ala Asp Leu Asp Phe Ala Arg Gln Tyr Tyr Glu Met Leu Tyr Asn 885 890 895 aca gct gac gag ctc ctg aac ctg gtg gtg gac ca tac 2737 Thr Ala Asp Glu Leu Leu Asn Leu Val Val Asp Gln Gly Val Lys Tyr 900 905 910 acg gag ctg gag tac atc cac gct ctg acc ctg ctg cac cgc agc caa 2785 Thr Glu Leu Glu Tyr Ile His Ala Leu Thr Leu Leu His Arg Ser Gln 915 920 925 act ggg gtg ggg gaa ctg acc acc ag ctg cag agg ctc 2833 Thr Gly Val Gly Glu Leu Thr Thr Gln Asn Thr Arg Leu Gln Arg Leu 930 935 940 aaa gag atc atc tgc gag cag gct gcc atc aag caa gcc acc aag gac 2881 Lys Glu Ile Ile Cys Glu Gln Ala Ala Ile Lys Gln Ala Thr Lys Asp 945 950 950 955 960 aag aag ata act acc gtt tagcagggcg tactgcggtt ggtgacgggg 2929 Lys Lys Igttc ttcttcc Valt ggtatgttat tgagtatatt ctgagcttag 2989 ttttctctac agtgatactt tagtggagag gaggtgtaag gattctttct ctctggtttt 3049 ggcttttcat ataaatgcta aaggaaggcg acagtacaga g tgttttggt tgaacaacta 3109 ctttaatgca gtcaaatcta acgggactag ggtgggatag ggaggaaggt ggtatcaaat 3169 tgttggactc tgaaaaacaa gtggatggat tactaatatt tgatttatta ctcaatatat 3229 atataattcc agccttggaa agtaggaaag taggctgcta cctaactttt agtcccttcc 3289 aaaaccattt agtagggttc tattacataa acagtagggt ttttcctctc ctgaccttat 3349 ccgtttacag ttcaatgaaa taagtgtatg tgcattgctg tctgtctcta ttgccaaaat 3409 caaataaatg gcttctcagc tgctgtttac aacaaacttc cctaaccaaa acagaacctc 3469 taatttaggg ctaggaatag aagtcttttg atcccagtcc gtgggacagt tttgtatgct 3529 gtatcttgta cacaggttgt aggttggttt attgccattt tgttttattt ctgctatata 3589 aaaaccaaga gccagacaat tagacaacta tggaggaatg aaaggcaatt caaacatctg 3649 cttgattccc gccccgccac ccctaatttc tgagagaata atggttagag aacattgcat 3709 ctcacttgaa acatcctttg ggggtaaatg attcttaggt gctcacttgg tctgagctca 3769 gctgaatgca gggaagatgg gacagagtga catttctcct ctgtgcggcc tccagctgag 3829 cctgtctctg aattgttccc tcccccgcaa tgtgggcact taccatgttc ctggcacact 3889 ggacctcacc atgtcccccg gtcaccagtc ctcttgctgc ccatgg ttca taggtcatag 3949 aaggcagcaa tgcactgact gggccacatc ttgaaaactc gtggaaaggg aaaggggagg 4009 agatgggact ttgaccacac acagtgatgc ctcacaccct gaaggtgggg gattttagat 4ag ttgtt gg ttg ttg <210> 135 <211> 4790 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (184) .. (2178) <400> 135 gaaagagaca ttcacttgga gggctcttgc tgaaaatggg tttaactctc cttttgccag 60 tcaccaccag cctgacctca tacactttta gtacaatgga gtggctgagc ctttgagcac 120 accaccatta catcatcgtg gcaaattaaa gaaggaggtg ggaaaagagg acttattgtt 180 gtc atg gcc cat gag atg att gga act caa att gtt act gag agg ttg 228 Met Ala His Glu Met Ile Gly Thr Gln Ile Val Thr Glu Arg Leu 1 5 10 15 gtg gct ctg ctg gaa agt gga acg gaa aaa gtg ctg cta att gat agc 276 Val Ala Leu Leu Glu Ser Gly Thr Glu Lys Val Leu Leu Ile Asp Ser 20 25 30 cgg cca ttt gtg gaa tac aat aca tcc cac att ttg gaa gcc att aat 324 Arg Pro Phe Val Glu Tyr Asn Thr Ser His Ile Leu Glu Ala Ile Asn 35 40 45 atc aac tgc tcc aag ctt atg aag cga agg ttg caa cag gac aaa gtg Ile Asn Cys Ser Lys Leu Met Lys Arg Arg Leu Gln Gln Asp Lys Val 50 55 60 tta att aca gag ctc atc cag cat tca gcg aaa cat aag gtt gac att 420 Leu Ile Thr Glu Leu Ile Gln His Ser Ala Lys His Lys Val Asp Ile 65 70 75 gat tgc agt cag aag gtt gta gtt tac gat caa agc tcc caa gat gtt 468 Asp Cys Ser Gln Lys Val Val Val Tyr Asp Gln Ser Ser Gln Asp Val 80 85 90 95 gcc tct ctc tct tca gac tgt ttt ctc act gta ctt ctg ggt aaa ctg 516 Ala Ser Leu Ser Ser Asp Cys Phe Leu Thr Val Leu Leu Gly Lys Leu 100 105 110 gag aag agc ttc aac tct gtt cac ctg ctt gca ggt ggg ttt gct gag 564 Glu Lys Ser Phe Asn Ser Val His Leu Leu Ala Gly Gly Ply Ahe Gla 115 120 125 ttc tct cgt tgt ttc cct ggc ctc tgt gaga aaa tcc act cta gtc 612 Phe Ser Arg Cys Phe Pro Gly Leu Cys Glu Gly Lys Ser Thr Leu Val 130 135 140 cct acc tgc att tct cag cct tgc tta cct gtt gcc aac att ggg cca 660 Pro Thr Cys Ile Ser Gln Pro Cys Leu Pro Val Ala Asn Ile Gly Pro 145 150 155 acc cga att ctt ccc aat ctt tat ctt ggc tgc cag cga gat gtc ctc 708 Thr Arg Ile Leu Pro Asn Leu Tyr Leu Gly Cys Gln Arg Asp Val Leu 160 165 170 175 aac aag gag ctg atg cag cag aat ggg att ggt tat gtg tta aat gcc 756 Asn Lys Glu Leu Met Gln Gln Asn Gly Ile Gly Tyr Val Leu Asn Ala 180 185 190 agc aat acc tgt cca aag cct gac ttt atc ccc gag tct cat ttc 804 Ser Asn Thr Cys Pro Lys Pro Asp Phe Ile Pro Glu Ser His Phe Leu 195 200 205 cgt gtg cct gtg aat gac agc ttt tgt gag aaa att ttg ccg tgg ttg 852 Arg Val Pro Val Asn Asp Ser Phe Cys Glu Lys Ile Leu Pro Trp Leu 210 215 220 gac aaa tca gta gat ttc att gag aaa gca aaa gcc tcc aat gga tgt 900 Asp Lys Ser Val Asp Phe Ile Glu Lys Ala Lys Ala Ser Asn Gly Cys 225 230 235 gtt cta gtg cac tgt tta gct ggg atc tcc cgc tcc gcc acc atc gct 948 Val Leu Val His Cys Leu Ala Gly Ile Ser Arg Ser Ala Thr Ile Ala 240 245 250 255 atc gcc tac atc atg aag agg atg gac atg tct tta gat gaa gct tac 996 Ile Ala Tyr Ile Met Lys Arg Met Asp Met Ser Leu Asp Glu Ala Tyr 260 265 270 aga ttt gtg aaa gaa aaa aga cct act ata tct cca aac ttc aat ttt 1044 Arg Phe Val Lys Glu Lys Arg Pro Thr Ile Ser Pro Asn Phe Asn Phe 275 280 285 285 ctg ggc caa ctc ctg gac tat gag aag aag att aag aac cag act gga 1092 Leu Gly Gln Leu Leu Asp Tyr Glu Lys Lys Ile Lys Asn Gln Thr Gly 290 295 300 gca tca ggg cca aag agc aaa ctc ag ctg ctc ag ctg gag aag cca 1140 Ala Ser Gly Pro Lys Ser Lys Leu Lys Leu Leu His Leu Glu Lys Pro 305 310 315 aat gaa cct gtc cct gct gtc tca gag ggt gga cag aaa agc gag acg 1188 Asn Glu Pro Val Pro Ala Val Ser Glu Gly Gly Gln Lys Ser Glu Thr 320 325 330 335 ccc ctc agt cca ccc tgt gcc gac tct gct acc tca gag gca gca gga 1236 Pro Leu Ser Pro Pro Cys Ala Asp Ser Ala Thr Ser Glu Ala Ala Gly 340 345 350 caa agg ccc gtg cat ccc gcc agc gtg ccc agc gtg ccc agc gtg cag 1284 Gln Arg Pro Val His Pro Ala Ser Val Pro Ser Val Pro Ser Val Gln 355 360 365 ccg tcg ctg tta gag gac agc ccg ctg gta cag gcg ctc agt ggg ctg 13 Ser Leu Leu Glu Asp Ser Pro Leu Val Gln Ala Leu Ser Gly Leu 370 375 380 cac ctg tcc gca gac agg ctg gaa gac agc aat aag ctc aag cgt tcc 1380 His Leu Ser Ala Asp Arg Leu Glu Asp Ser Asn Lys Leu Lys Arg Ser 385 390 395 ttc tct ctg gat atc aaa tca gtt tca tat tca gcc agc atg gca gca 1428 Phe Ser Leu Asp Ile Lys Ser Val Ser Tyr Ser Ala Ser Met Ala Ala Ala 400 405 410 415 tcc tta cat ggc ttc tcc tca t ca gaa gat gct ttg gaa tac tac aaa 1476 Ser Leu His Gly Phe Ser Ser Ser Glu Asp Ala Leu Glu Tyr Tyr Lys 420 425 430 cct tcc act act ctg gat ggg acc aac aag cta tgc cag ttc tcc cct 1524 Pro Ser Thr Thr Leu Asp Gly Thr Asn Lys Leu Cys Gln Phe Ser Pro 435 440 445 gtt cag gaa cta tcg gag cag act ccc gaa acc agt cct gat aag gag 1572 Val Gln Glu Leu Ser Glu Gln Thr Pro Glu Thr Ser Pro Asp Lys Glu 450 455 460 gaa gcc agc atc ccc aag aag ctg cag acc gcc agg cct tca gac agc 1620 Glu Ala Ser Ile Pro Lys Lys Leu Gln Thr Ala Arg Pro Ser Asp Ser 465 470 475 cag agcc aag cga ttg cat tcg gtc aga acc agc ag agc ggc acc gcc 1668 Gln Ser Lys Arg Leu His Ser Val Arg Thr Ser Ser Ser Gly Thr Ala 480 485 490 495 cag agg tcc ctt tta tct cca ctg cat cga agt ggg agc gtg gag gac 1716 Gln Arg Ser Leu Leu Ser Pro Leu His Arg Ser Gly Ser Val Glu Asp 500 505 510 aat tac cac acc agc ttc ctt ttc ggc ctt tcc acc agc cag cag cac 1764 Asn Tyr His Thr Ser Phe Leu Phe Gly Leu Ser Thr Ser Gln Gln His 515 520 525 ctc acg aa g tct gct ggc ctg ggc ctt aag ggc tgg cac tcg gat atc 1812 Leu Thr Lys Ser Ala Gly Leu Gly Leu Lys Gly Trp His Ser Asp Ile 530 535 540 ttg gcc ccc cag acc tct acc cct tcc ctg acc agc agc tgg 1860 Leu Ala Pro Gln Thr Ser Thr Pro Ser Leu Thr Ser Ser Trp Tyr Phe 545 550 555 gcc aca gag tcc tca cac ttc tac tct gcc tca gcc atc tac gga ggc 1908 Ala Thr Glu Ser Ser His Phe Tyr Ser Ala Ser Ala Ile Tyr Gly Gly 560 565 570 575 agt gcc agt tac tct gcc tac agc tgc agc cag ctg ccc act tgc gga 1956 Ser Ala Ser Tyr Ser Ala Tyr Ser Cys Ser Gln Leu Pro Thr Cys Gly 580 585 590 gac caa gtc c tat tc gtg agg cgg cag aag cca agt gac aga gct 2004 Asp Gln Val Tyr Ser Val Arg Arg Arg Gln Lys Pro Ser Asp Arg Ala 595 600 605 gac tcg cgg cgg agc tgg cat gaa gag agc ccc ttt gaa aag cag ttt 2052 Asp Ser Arg Arg Ser Trp His Glu Glu Ser Pro Phe Glu Lys Gln Phe 610 615 620 aaa cgc aga agc tgc caa atg gaa ttt gga gag agc atc atg tca gag 2100 Lys Arg Arg Arg Ser Cys Gln Met Glu Phe Gly Glu Ser Ile Met Ser Glu 625 630 635 aac agg tca cgg gaa gag ctg ggg aaa gtg ggc agt cag tct agc ttt 2148 Asn Arg Ser Arg Glu Glu Leu Gly Lys Val Gly Ser Gln Ser Ser Phe 640 645 650 655 tcg ggc agc atg tg ag attag tgag gacacttgtg 2198 Ser Gly Ser Met Glu Ile Ile Glu Val Ser 660 665 acttctatag acaatttttt tttcttgttc acaaaaaaat tccctgtaaa tctgaaatat 2258 atatatgtac atacatatat atttttggaa aatggagcta tggtgtaaaa gcaacaggtg 2318 gatcaaccca gttgttactc tcttaacatc tgcatttgag agatcagcta atacttctct 2378 caacaaaaat ggaagggcag atgctaggat cccccctaga cggaggaaaa ccattttatt 2438 cagtgaatta cacatcctct tgttcttaaa aaagcaagtg tctttggtgt tggaggacaa 2498 aatcccctac cattttcacg ttgtgctact aagagatctc aaatattagt ctttgtccgg 2558 acccttccat agtacacctt agcgctgaga ctgagccagc ttgggggtca ggtaggtaga 2618 ccctgttagg gacagagcct agtggtaaat ccaagagaaa tgatcctatc caaagctgat 2678 tcacaaaccc acgctcacct gacagccgag ggacacgagc atcactctgc tggacggacc 2738 attaggggcc ttgccaaggt ctaccttaga gcaaacccag tacctcagac aggaaagtcg 2798 gggctttgac cacta ccata tctggtagcc cattttctag gcattgtgaa taggtaggta 2858 gctagtcaca cttttcagac caattcaaac tgtctatgca caaaattccc gtgggcctag 2918 atggagataa tttttttttc ttctcagctt tatgaagaga agggaaactg tctaggattc 2978 agctgaacca ccaggaacct ggcaacatca cgatttaagc taaggttggg aggctaacga 3038 gtctacctcc ctctttgtaa atcaaagaat tgtttaaaat gggattgtca atcctttaaa 3098 taaagatgaa cttggtttca agccaaatgt gaatttattt gggttggtag cagagcagca 3158 gcaccttcaa attctcagcc aaagcagatg tttttgccct ttctgcttca ctgcatggat 3218 acagttggta aaatgtaata atatggcaga attttatagg aaacttccta gggaggtaaa 3278 ttatgggaag attaagaaag gtacaaattg ctgaggagaa gcaggaaacc tgtttcctta 3338 gtggctttta tcccctcggc atgcgatggg gctgatgttt ctataattgc ctcagacttt 3398 cacatttact agtagggctg agagaggctt tagtgaggaa ggaatattca gaataaaacg 3458 gttgagaaag ctgagaagac cattgagttt tgatcagttg tgaatagagt gcaaagccat 3518 ggccaagctg tttttggaaa cgctggccgg cgtgtcttca gtggaaaaag caaatcaaaa 3578 tggagcgaga gcaaaggggc gtcctcagtc ctcaacctac aatcactgta tggaatcggt 3638 cctggcagct gaacatagga ggtcactgga acaagtgata gtgcagattg gctttcaaac 3698 atcctcctgg cttgagtttt atcagctaca gtgtgggtcc tcttttgaag ccttaattca 3758 caacagcagc tttttggggg tggggctggg cgggtgttgt cattgttctt tcccttcctg 3818 taagtgtcgc tagttgctgc ctcgtatctc aggtttttct ctgtttttga gaaatggaca 3878 gttttttgac caggatgtga cttcatgttt cctatggtga cttctaaaac cagcacagaa 3938 tgatatgact caacacagac cgacttggtt atggggatga tgagccgcac agacctcact 3998 agttgtgcac aaataatgtg ctatgatggg gtgtaaagtg aaggcagaag agggtcagcc 4058 gcattgttat gatactggga aagtgctggt caacgatttg agttagtttt tagatataca 4118 ttgaaatctt taatcagaca ttctcaagtt tcacacagta gtttttgatg ttatgtacac 4178 acacaccaaa tgtgtaacag ttcaccactt ccagagtgtg gtcatgccca aaacatgttt 4238 aagaaaggaa agcagtagct ccttgctaac gatgtttcag gaggtttggg ggacttggtt 4298 ttaatgagct tctgtcattt agggcttctc ttggccatgg tccccttcct tctggaactg 4358 tgatgtagtc acatcctaca gcctttagtg ctggttcact agtgtcagat aatcagttct 4418 tggaatcgag actgccgtgg cgaaggggtg gcctcggagg caggctctgg agctgcttgg 4478 atgtctttag gtggggtggt ggctg gctct cttcagcatg taattgggga aaccctcgtt 4538 tctactaggg gtgatacaga tggtgatttt aaagagcaaa actagacttc tatgtgagaa 4598 gtgctggaaa atgatttagg acatgtgtaa agttagatgg aaagactgta aatgtttaat 4658 atgaatatag tgttcttttg aagtaaggcc agctgttgaa cggttaaact gtgcatttct 4718 cattttgatg tgtcatgtat gttaatgtat gaaatgatta aataaaatca aaactggtac 4778 ctgtttatac at 4790 <210> 136 <211> 3909 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2187) <400> 136 cct gca tca aat cgt act ttg aaa gca ctc gag gcc caa aaa atg atg 48 Pro Ala Ser Asn Arg Thr Leu Lys Ala Leu Glu Ala Gln Lys Met Met 1 5 10 15 aaa aag aaa aaa gag gca gaa gat gtg gct gat gaa att aag aag ttc 96 Lys Lys Lys Lys Glu Ala Glu Asp Val Ala Asp Glu Ile Lys Lys Phe 20 25 30 gaa gca tta ata aaa aag gat ctc caa gca aaa gaa agt gca tcc aag 144 Glu Ala Leu Ile Lys Asp Leu Gln Ala Lys Glu Ser Ala Ser Lys 35 40 45 act tct tta gat aca gca ggc cag aca acc acc gat ttg tta aat act 192 Thr Ser Leu Asp Thr Ala Gly Gln Thr Thr Thr Thr Asp Leu Leu Asn Thr 50 55 60 tac tca gat gat gag tac att aaa aaa atc cag aag cgc ctt gaa gaa 240 Tyr Ser Asp Asp Glu Tyr Ile Lys Lys Ile Gln Lys Arg Leu Glu Glu 65 70 75 80 gat gct ttt gca cga gag caa agg gag aaa aga cgg cgg aaa ttg tta 288 Asp Ala Phe Ala Arg Glu Gln Arg Glu Lys Arg Arg Arg Lys Leu Leu 85 90 95 atg gac cag tta ata gcc cac gaa gca caa gag gag gct tat cgg gag 336 Met Asp Gln Leu Ile Ala His Glu Ala Glu Glu Glu Ala Tyr Arg Glu 100 105 11 0 gaa cag ctg att aac cgg ctg atg cgg cag tcc cag cag gag cgc agg 384 Glu Gln Leu Ile Asn Arg Leu Met Arg Gln Ser Gln Gln Glu Arg Arg 115 120 125 att gcc gtg cag ctc atg cat gtt cgg cat gaaag gtt tta tgg 432 Ile Ala Val Gln Leu Met His Val Arg His Glu Lys Glu Val Leu Trp 130 135 140 caa aac aga att ttc aga gaa aaa caa cat gag gaa aga cga ctt aaa 480 Gln Asn Arg Ile Phe Arg Glu Lys Gln His Glu Glu Arg Arg Leu Lys 145 150 155 160 gat ttc cag gat gct ctt gat cga gaa gcg gct ttg gca aaa caa gcc 528 Asp Phe Gln Asp Ala Leu Asp Arg Glu Ala Ala Leu Ala Lys Gln Ala 165 170 175 att atg gaa gaa caa ttc ctt aaa gaa aag aga ttt cat gat 576 Lys Ile Asp Phe Glu Glu Gln Phe Leu Lys Glu Lys Arg Phe His Asp 180 185 190 cag att gct gtg gaa aga gct caa gct cgt tat gaa aag cat tatca Ile Ala Val Glu Arg Ala Gln Ala Arg Tyr Glu Lys His Tyr Ser 195 200 205 gta tgt gca gaa att ttg gat caa ata gtt gat ttg tcc act aaa gtg 672 Val Cys Ala Glu Ile Leu Asp Gln Ile Val Asp Leu Ser Thr Lys V al 210 215 220 gca gac tat cga atg ttg aca aat aat ctg att ccg tat aag ttg atg 720 Ala Asp Tyr Arg Met Leu Thr Asn Asn Leu Ile Pro Tyr Lys Leu Met 225 230 235 240 cat gat tgg aag gaa cta ttt ttt aat gca aaa ccc ata tat gaa caa 768 His Asp Trp Lys Glu Leu Phe Phe Asn Ala Lys Pro Ile Tyr Glu Gln 245 250 255 gcc tct gtt aag aca cta cct gct aac ccc tca aga gaa caa ctt aca 816 Ala Ser Val Lys Thr Leu Pro Ala Asn Pro Ser Arg Glu Gln Leu Thr 260 265 270 gaa ctg gag aaa agg gac ttg cta gat acc aat gat tat gaa gaa tat 864 Glu Leu Glu Lys Arg Asp Leu Leu Asp Thr Asn Asp Tyr Glu Glu Tyr 275 280 285 ag aac atg gtt gga gag tgg gcc tta cca gaa gaa atg gtt gac aat 912 Lys Asn Met Val Gly Glu Trp Ala Leu Pro Glu Glu Met Val Asp Asn 290 295 300 tta cca ccc tcc aac aat tgc ata ctg ggc cat att ctt c cta 960 Leu Pro Pro Ser Asn Asn Cys Ile Leu Gly His Ile Leu His Arg Leu 305 310 315 320 gct gaa aaa tct ctt cct cct cga gcg gaa tca aca aca cct gaa tta 1008 Ala Glu Lys Ser Leu Pro Pro Arg Ala Glu SerThr Thr Pro Glu Leu 325 330 335 cct tca ttt gct gtt aaa gga tgc tta ttg ggg aaa aca tta agt gga 1056 Pro Ser Phe Ala Val Lys Gly Cys Leu Leu Gly Lys Thr Leu Ser Gly 340 345 350 aaa act acc att tta agg tct cta caa aaa gac ttt cct ata cag ata 1104 Lys Thr Thr Ile Leu Arg Ser Leu Gln Lys Asp Phe Pro Ile Gln Ile 355 360 365 ctt tct att gac act ctt gtc caa gaa gct atc caa gca ttt cat gac 1152 Leu Ser Ile Asp Thr Leu Val Gln Glu Ala Ile Gln Ala Phe His Asp 370 375 380 aat gaa aaa gtc agt gag gtt cta cca att cag aaa aat gat gaa gaa 1200 Asn Glu Lys Val Ser Glu Val Leu Pro Ile Gln Lys Asn Asp Glu Glu 385 390 395 400 gat gct cta cca gtt ctg caa gag gag att aaa gaa agc cag gat cca 1248 Asp Ala Leu Pro Val Leu Gln Glu Glu Ile Lys Glu Ser Gln Asp Pro 405 410 415 caa cat gta ttt tca gct ggt cca gtt tca gat gaa gta tta cca gaa 1296 Gln His Val Phe Ser Ala Gly Pro Val Ser Asp Glu Val Leu Pro Glu 420 425 430 aca gaa ggt gaa aca atg ctt agt gct aat gct gat aaa aca cca aaa 1344 Thr Glu Gly Glu Thr Met L eu Ser Ala Asn Ala Asp Lys Thr Pro Lys 435 440 445 gct gaa gaa gtc aaa tca agt gat agt ttc tta aaa ctc act aca cgt 1392 Ala Glu Glu Val Lys Ser Ser Asp Ser Phe Leu Lys Leu Thr Thr Arg 450 455 460 gct cag ctt ggt gca aaa tca gaa cag ttg ctg aag aaa gga aag agc 1440 Ala Gln Leu Gly Ala Lys Ser Glu Gln Leu Leu Lys Lys Gly Lys Ser 465 470 475 480 att cct gat gtg ctg ctt gtt gat atc ata gta aat gag 1488 Ile Pro Asp Val Leu Leu Val Asp Ile Ile Val Asn Ala Ile Asn Glu 485 490 495 ata cct gtg aat caa gac tgt atc cta gat ggt ttt cca atg act tta 1536 Ile Pro Val Asn Gln Asp Cys Ile Leu Asp Gly Phe Pro Met Thr Leu 500 505 510 aac caa gca cag ctt ctg gaa gaa gct ctt aca ggc tgc aat aga aac 1584 Asn Gln Ala Gln Leu Leu Glu Glu Ala Leu Thr Gly Cys Asn Arg Asn 515 520 525 ctc aga gaa aaa aaa gca caa aaa tcc aca ttg gct att 1632 Leu Thr Glu Val Glu Arg Lys Lys Ala Gln Lys Ser Thr Leu Ala Ile 530 535 540 gat cct gcg act tcc aaa gaa ata cct ctt ccc tct cct gca ttt gat 1680 Asp Pr o Ala Thr Ser Lys Glu Ile Pro Leu Pro Ser Pro Ala Phe Asp 545 550 555 560 ttt gtc ata tta tta gat gtt tca gat act tcc tca atg agt cgc atg 1728 Phe Val Ile Leu Leu Asp Val Ser Asp Thr Ser Ser Met Ser Arg Met 565 570 575 aat gat att ata gct gaa gaa ttg tcc tat aaa act gct cac gaa gat 1776 Asn Asp Ile Ile Ala Glu Glu Leu Ser Tyr Lys Thr Ala His Glu Asp 580 585 590 atc agt caa cgt gta gct gct ga caa gat aag gat gga gac caa 1824 Ile Ser Gln Arg Val Ala Ala Glu Asn Gln Asp Lys Asp Gly Asp Gln 595 600 605 aat tta aga gac cag ata caa cat aga att ata ggc ttc ttg gac aac 1872 Asn Leu Arg Asp Gln Gln His Arg Ile Ile Gly Phe Leu Asp Asn 610 615 620 tgg cct tta ttg gag caa tgg ttt tca gag cca gaa aat att ttg ata 1920 Trp Pro Leu Leu Glu Gln Trp Phe Ser Glu Pro Glu Asn Ile Leu Ile 625 630 635 aaa atc aat gct gaa ata gat aag gaa tct tta tgt gaa aaa gta aaa 1968 Lys Ile Asn Ala Glu Ile Asp Lys Glu Ser Leu Cys Glu Lys Val Lys 645 650 655 gaa att ctt acg act gaa ata gca aaa aaa aag at gtt gag aag 2016 Glu Ile Leu Thr Thr Glu Ile Ala Lys Lys Lys Asn Lys Val Glu Lys 660 665 670 aaa tta gaa gaa aag gaa gct gag aaa aaa gca gca gct tcc ctg gct 2064 Lys Leu Glu Glu Lys Glu Ala Glu Lys Ala Ala Ala Ser Leu Ala 675 680 685 gag ctt cca ctt cct aca cct cct cct gct cct cct cct gaa cca gaa 2112 Glu Leu Pro Leu Pro Thr Pro Pro Pro Ala Pro Pro Pro Glu Pro Glu 690 695 700 aaa gag aag gaa att cat caa agc cat gtg gct tca aaa act cct act 2160 Lys Glu Lys Glu Ile His Gln Ser His Val Ala Ser Lys Thr Pro Thr 705 710 715 720 gca aaa gga aaa cct caa tca ggt gat tgacagaatg atttataatc 2207 Ala Lys Gly Lys Pro Gln Ser Gly Asp 725 ctgttttcag tttcttattt ttactcagta aagaattata aattatagtc tatctacatt 2267 cagactttgg gcaacttcaa tcatatgaaa caaggcttta cactcagatg gaagtggaaa 2327 agccctcgga gtagctaaaa gcgtagttgt tacaaagccc aacttctttg ccatgtagga 2387 ggagacatgg agtcatcaca cctaggtcta ctgattagag taagaccaca gacgagaaga 2447 ggaaaaggca cagagtaaca ggtaacttca ggcagatcaa gaggatacac gtctgtgtgc 2507 tgaactata g agttacattt atgtaatgag taagaacatc ttaataaaat aagaatgagt 2567 atagctggtt ttccaccaga ataagggaac aaattaacag caaccattag aactagaatt 2627 tatatgtaat tgtaaatctt caggactatg tgattataaa agtatagaaa caagctcctg 2687 ccatctcagt aaacatatat ttatggacac agagataaag agcctagata gagaacactt 2747 ttagtttaag tttgttctag atccttaacc gctatggacc ataagtctag cattaagtgg 2807 cagacaatga atataatgac aaaagtgaag tgcttaattg ttgtaatgca tgatattggt 2867 agagtgtcag tatccatttg tgtgtgtata taaaacaaat gaggctctgg tttctagttt 2927 cagctttata aatggctgac tgtgcagtta caccatgtct acctaagtat ctttgatact 2987 gtgtcatgac cacatttcta aactctatag tctttctgcc tcacggagat ttgagatagg 3047 tcttaatttt taaaattaaa cttattcata ttaaacaaag acatatgaag actttagtaa 3107 gatatattat gatatattaa agaccattct gctccaggaa attagaaatt aactacaggc 3167 aaaatacaca catcctaaaa aatgttttta tcatgtcaac aataaaacac aaagacatga 3227 attaaacata cacccttttc ccgctgtctc attaggaaat taaaaaacaa ttcagaggtc 3287 tggaggaaaa tggaaatatt taaaatgctt tttagaactg gggaagacag gccaagcatg 3347 gtggctcatc cct gtaatcc cagcactttg ggaggctgag gtgggcagat caccagaaat 3407 caggagttcg agaccccgct ggccaacagg gcaaaaccca tctctaccaa aaatacaaaa 3467 attagctggg cgtggtggca ggcacctgta atcccagctg cttgggaggc tgaggcagga 3527 gaattgcttg aacctgagag gcggaggttg cagtgagccg agattgcccc actgcactct 3587 agcctggggg atagagtgaa actctacctc caaaaaaaaa gaaaagaaaa ataactgagg 3647 aagacagttt tcacagtggg tcaggtgagc ctagaattat cgaatatcgt cctttaacct 3707 atagctatga ctctaggtta aagctcctcc tcagcttgct ccagtcaaga gtatctatgt 3767 atttgagcca tttcctgaaa ccagactcta gtgtttctga tcagaccagc tcagtcttta 3827 agtttctgaa gtttgtttgc tattttataa ttatattctt gaatactgtg cattgaagaa 3887 ataataaatc tattgttgct tt 3909 <210> 137 <211> 4380 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (284) .. (1873) <400> 137 gcatatcttg agtagaactt aacatatctt gaatgggata tttttttctt ttattcttat 60 gagtggtctc acacaggacc aaacagcagg ccagcatagc accacgtgat ctgagcttgt 120 ttttactctc tcctttttca taaacagagt cccagattaa tgccagtagt tgattttggg 180 tctttggggt agtgaagctt gtggatttga cttctctgat tccttttgct gaccttgagt 240 ggattgtatc tttcactgtt aattataata atttaaaaat tga gtt cta ctt act 295 Val Leu Leu Thr 1 gga cat gaa tct ctg cac ttg aaa gtt aac ata tta aaa gca tat ttt 343 Gly His Glu Ser Leu His Leu Lys Val Asn Ile Leu Lys Ala Tyr Phe 5 10 15 20 ttt tct tcc ttg gtt ttc ttg ttc atg tgg ata acc cag aga atg cct 391 Phe Ser Ser Leu Val Phe Leu Phe Met Trp Ile Thr Gln Arg Met Pro 25 30 35 gaa tct aag gtg cca tcc tct gag aat cat cgc cca gaa atg tgc tct 439 Glu Ser Lys Val Pro Ser Ser Glu Asn His Arg Pro Glu Met Cys Ser 40 45 50 agc tgc aat gtt cct ctt ccc att gga gat agc agc tcc ttc tct ggg 487 Ser Cys Asn Val Pro Leu Pro Ile Gly Asp Ser Ser Ser Phe Ser Gly 55 60 65 agt tgt tcc agc agt cca gaa agg ata gtt tct caa act tcc tct gtt 535 Ser Cys Ser Ser Ser Pro Glu Arg Ile Val Ser Gln Thr Ser Ser Val 70 75 80 gag aac cca ttg gag aac cag aaa aat gat caa aat aat tca gat act 583 Glu Asn Pro Leu Glu Asn Gln Lys Asn Asp Gln Asn Asn Ser Asp Thr 85 90 95 100 aag atc tct gag aca gag acc ctt aaa tca tca cag aat ttt cag act 631 Lys Ile Ser Glu Thr Glu Thr Leu Lys Ser Ser Gln Asn Phe Gln Thr 105 110 115 ctg cct tca tct cca ctt ctg gtc ccc caa gaa tct ttg gcc tct tct 679 Leu Pro Ser Ser Pro Leu Leu Val Pro Gln Glu Ser Leu Ala Ser Ser 120 125 130 gag gtc aaa gag aat tta cgt ata gat tct tct tca gct tca cag cat 727 Glu Val Lys Glu Asn Leu Arg Ile Asp Ser Ser Ser Ala Ser Gln His 135 140 145 gga cgg gat gcc atc ctc tat ctc cag aca caa gta gct gaa atg tcc 775 Gly Arg Asp Ala Ile Leu Tyr Leu Gln Thr Gln Val Ala Glu Met Ser 150 155 160 cga gtg ata cgt gat ctg cag tcc agg agc tgt ttt aga ttt cat cat 823 Arg Val Ile Arg Asp Leu Gln Ser Arg Ser Cys Phe Arg Phe His His 165 170 175 180 tct agg cca agt gag aac tcc tca gtt cct tgg gac a tc tcc acc tct 871 Ser Arg Pro Ser Glu Asn Ser Ser Val Pro Trp Asp Ile Ser Thr Ser 185 190 195 aaa gag gaa aat tta tcc aca gtt gaa gaa gaa act gat tac aaa tca 919 Lys Glu Glu Asn Leu Ser Thr Val Glu Glu Glu Thr Asp Tyr Lys Ser 200 205 210 cca tca gct gat gac aaa ggg cag cca tct gac ccc agc caa tct agt 967 Pro Ser Ala Asp Asp Lys Gly Gln Pro Ser Asp Pro Ser Gln Ser Ser 215 220 225 ttc aca ggt ctt ttg aag aga atg gaa caa aga ggt gtt ata aaa agg 1015 Phe Thr Gly Leu Leu Lys Arg Met Glu Gln Arg Gly Val Ile Lys Arg 230 235 240 gtg aca tta caa tct gaa gcg gag tca tgt gaa ggg aaa cct gat tgt Thr Leu Gln Ser Glu Ala Glu Ser Cys Glu Gly Lys Pro Asp Cys 245 250 255 260 gtg act tct aaa aaa cgt ttg gtt cct cca ttg cat cct ctt ctg aga 1111 Val Thr Ser Lys Lys Arg Leu Val Pro Pro Leu His Pro Leu Leu Arg 265 270 275 att gcc acc act gag gtt ttt aaa gac cct gct gat tgc cat cct tct 1159 Ile Ala Thr Thr Glu Val Phe Lys Asp Pro Ala Asp Cys His Pro Ser 280 285 290 tcc ttc atg gga cac agg gta tat c ct gtg gcc aag gac acc tct cct 1207 Ser Phe Met Gly His Arg Val Tyr Pro Val Ala Lys Asp Thr Ser Pro 295 300 305 ttc caa cca aac cca cca gct gaa ggc ccc att gta gaa gca tta gaa 1255 Phe Gln Pro Asn Pro Pro Ala Glu Gly Pro Ile Val Glu Ala Leu Glu 310 315 320 cac agc aaa aga gga aac aca aca tcc cct cta gat tct acc tca aaa 1303 His Ser Lys Arg Gly Asn Thr Thr Ser Pro Leu Asp Ser Thr Ser Lys 325 330 335 340 gaa atg gag gtc atg ggt tgt agg ttt tac cac gct gcc tcc att gca 1351 Glu Met Glu Val Met Gly Cys Arg Phe Tyr His Ala Ala Ser Ile Ala 345 350 355 gcc cga gct gct agc tac atg gcc tat atg act caa tat cag cgt aaa 1399 Ala Arg Ala Ala Ser Tyr Met Ala Tyr Met Thr Gln Tyr Gln Arg Lys 360 365 370 ctc tgg gaa gac atg gaa gat ctg gtt cat gac cca gaa ttt gat cgt 1447 Leu Trp Glu Asp Met Glu Asp Leu Val Asp Pro Glu Phe Asp Arg 375 380 385 gga aaa gca aga tgc ata ata tct gat ggt atg gat gca ggc ctt tgg 1495 Gly Lys Ala Arg Cys Ile Ile Ser Asp Gly Met Asp Ala Gly Leu Trp 390 395 400 caa ctt tgt a ct act agg gac ata atg gac tct gta gtc aga gtt atg 1543 Gln Leu Cys Thr Thr Arg Asp Ile Met Asp Ser Val Val Arg Val Met 405 410 415 420 gcc atg gcc ata gac tat aga cgg cag gcc tgg ctt cga ctt aca tct 1591 Ala Met Ala Ile Asp Tyr Arg Arg Gln Ala Trp Leu Arg Leu Thr Ser 425 430 435 ctc act aag aaa acc cag gag aag atc tcc cac ttg ccc ttt gat ggt 1639 Leu Thr Lys Lys Thr Gln Glu Lys Ile Ser His Leu Pro Phe Asp Gly 440 445 450 act tcc ctt ttt gga caa gat gtg aaa gct gtt gtt gca gaa gac aac 1687 Thr Ser Leu Phe Gly Gln Asp Val Lys Ala Val Val Ala Glu Asp Asn 455 460 465 aat ata aaa gaa aat gac tat aaa gat cac aaa tac tat aat cag cat 1735 Asn Ile Lys Glu Asn Asp Tyr Lys Asp His Lys Tyr Tyr Asn Gln His 470 475 480 cga tac ttt tat agt cat gat cag aaa gca cat tat cac aat aga gga 1783 Arg Tyr Phe Tyr Ser His Asp Gln Lys Ala His Tyr His Asn Arg Gly 485 490 495 500 tac tcc aaa ggg gat tgg tac aaa cct cga aac cac ccc tat aga tat 1831 Tyr Ser Lys Gly Asp Trp Tyr Lys Pro Arg Asn His Pro Tyr Arg Tyr 50 5 510 515 aga aag aag gga gac tct cca gaa cgc cat ggg tac aag aat 1873 Arg Lys Lys Gly Asp Ser Pro Glu Arg His Gly Tyr Lys Asn 520 525 530 taataacctg tttaatcatccat gag tcattcag tcattagca tcattg tcatatg tcattg cagctgacat ttgaattcta gacttttgaa atgaagtata taataaagaa 2053 actcatgact tggccaagtg agcagtggag actttcttga aagggttgga caaatgttta 2113 tcctttattt ctggtccaaa aataagtgtg gaggaggacc actcaggaat ctgaatcctc 2173 ttgtgattaa agaaaaatat aaagatgtgt tcctcaggaa aatcttattt gtaaactgag 2233 gactagcaga ttttgaatct agaaataata ctagatgtct gtttactaag accagaggta 2293 aatccttaac ttttaggtta tcagtgcttc cttgttcagg cttcagtttg acagatcttc 2353 acaaaatgac acatctgtta aaatgtcttt atgtcaagat ggtcaactca ccaagagtcc 2413 gtactactat caagctctgt gagacttcag aatcagccat gaagctttgt gtcaactgga 2473 attcaaatca aattttgcca aatccagttt gcttcccctt ggaatggcta gatgtcgcag 2533 gtctattatg gacaccaact ggaaaaagac ttctacctgt aacatctg tagaaattc ta tcttcatcaa gactttgatg gccaccatac catcactact cataaagcta 2653 catgtgagag aattgtttgt tgttatcaat cctaatagtc tttgacctat caagctctcg 2713 tatcaagctg taagactgag tcatggtagt ctctcactgt aagctgggcc tttcaccaag 2773 atggccttct taaacaacct accttctaaa catttaattc ttttgagctt gatagtgcat 2833 cacactctaa atacaaaaaa gatacgcaca tcagtgccct ggaaataaag gatgttacac 2893 gatccaggca tgcaaatctg aactcctaag accaagaatt ccaaacatgc ctgacaatct 2953 tgtcccctta ttgtaataaa gagggatacc atcagtctag attttattga gaatccttaa 3013 gatttaaagc atagctgtgg atgtggtgaa gagaacaagc cacacagctc tgtttctgga 3073 tatctaagtg atgatatcca ttaatgattt gaaaggctga aatcaagatt taagtgatac 3133 gctcttggtt aattggttac ttaatttagt cagattctta gtgtaagaga cagcttatct 3193 ttttgctccc aattggtccc attaatagtt tttcaccata ctggaactgg cagcagatac 3253 ctcaattata tgtcccacag tatcttctct ttagactcaa ggtagtggat gtatggtata 3313 tcagccctta gatccatgtc ttcacagcat gacatcagga atggagaata tgtcaaattt 3373 gaggggtctg aatacatcac ctagtattat ttgcttggca gccaaaaaca gttgttttta 3433 ttgacagact taa ttctgta acttctgcgt tttttcatct gcttgatcaa ggcattttgg 3493 atgtactgct aatggaatat ggcactgttt tacggtttat gtggcttctg ttcttgccac 3553 agttgttgca cagtggtaat tgatgttttc tctggtgcca cactttttaa taatctattg 3613 gaagctcatt cctcctcccc catcataacc atattcagca cccattttta aatctacttt 3673 tcttccttat ttgtgctaca gaggttgatg gcgtaaattt tcctacttgg aagaaattac 3733 tttatcagtt aatttcaggg tactgtattg atcttgtttg tcctatttgt agattaaact 3793 tgaactagtc ttaataaagg ggatattgtt ttgcaaattt agcccagtca tatcaagagt 3853 taatatttat cttatttttc tgtattttac tcaaaatttt atttccactt ctgtagaaat 3913 aggtccatgc cagtgttctc tacaaagtgt ctttcaaact aaactctaga agaatatcga 3973 ttacctgaac agaaacaaag gcctaagaaa tcatacattt ttgtagctta tgtgtattgc 4033 accaatcaag caatcccatg tgctcttgat attggcactg tagttttatc ttagaggact 4093 tgccactgga gaactcagtg gtgagagacc ttggaaatgt tttatgtggc tgcacataag 4153 tgtttctgac tagctaaggc tacttcagac ttttcacttt ccatttgtcc ccttttcctt 4213 ccctgaatta gatgctatgt cataaacttg gtggtttttg aaatactctt atttcaaacc 4273 ttaaactaaa ccgaaata ag ttatgcctga gaatgcgttt gtctgaaacg attttggcac 4333 ttccctttaa tatgcttccc cttccctttg ccttttaaat tgtggtt 4380 <210> 138 <211> 4772 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (224) .. (3334) <400> 138 agagatttcc acagaaggac tgggatgata caccttttcc acagggaatt gagttgtttt 60 gtcagcctgg cgggtggcag ctgtccagag agaggaagca gccaacgttc tttgtggttg 120 tcctgacaga cattgactca gatcgacatt actgctcatg cctaaccttc tatgaggcag 180 agatcaatct tcagggaaca aagaaggaag agattgaagg tga agc aaa agt gtc 235 Ser Lys Ser Val 1 tgg ttt aat tca gcc tgc aga agt gtt tgc tcc caa aag cct ggt gct 283 Trp Phe Asn Ser Ala Cys Arg Ser Val Cys Ser Gln Lys Pro Gly Ala 5 10 15 20 tgc ctg ggt ttg atc tat acc gtg tat gtg gac agc ctg aat gtc tcc 331 Cys Leu Gly Leu Ileyr Thr Val Tyr Val Asp Ser Leu Asn Val Ser 25 30 35 ttg gaa agt cta att gca aac ctt tgt gcc tgc ctt gtc cca gcg gct 379 Leu Glu Ser Leu Ile Ala Asn Leu Cys Ala Cys Leu Val Pro Ala Ala 40 45 50 gga ggg tct cag aag ctg ttt tct ttg ggt gca gga gat aga cag ttg 427 Gly Gly Ser Gln Lys Leu Phe Ser Leu Gly Ala Gly Asp Arg Gln Leu 55 60 65 atc cag act cct tta cat gat agt ctt cct atc acg ggc act agt gtg 475 Ile Gln Thr Pro Leu His Asp Ser Leu Pro Ile Thr Gly Thr Ser V al 70 75 80 gct ctc ctg ttc cag caa ttg gga att caa aat gtc ctc agc ctc ttt 523 Ala Leu Leu Phe Gln Gln Leu Gly Ile Gln Asn Val Leu Ser Leu Phe 85 90 95 100 tgt gca gtc ctc aca aga gaaat ctc ttc cat tct gca agt ttc 571 Cys Ala Val Leu Thr Glu Asn Lys Val Leu Phe His Ser Ala Ser Phe 105 110 115 cag aga ctt agt gat gct tgt aga gcc ctg gaa tct tta atg ttt cct 619 Gln Arg Leu Ser Asp Ala Cys Arg Ala Leu Glu Ser Leu Met Phe Pro 120 125 130 ctt aaa tat agt tat cct tat atc cct att ctc ccg gct cag cta ctg 667 Leu Lys Tyr Ser Tyr Pro Tyr Ile Pro Ile Leu Pro Ala Gln Leu Leu 135 140 145 gaa gtt cta agt tcc cca acg cct ttc att att gga gta cat tct gtc 715 Glu Val Leu Ser Ser Pro Thr Pro Phe Ile Ile Gly Val His Ser Val 150 155 160 ttt aaa act gat gtc cat gaa ctt tta gat gta atc ata gca gat ttg 763 Phe Lys Thr Asp Val His Glu Leu Leu Asp Val Ile Ile Ala Asp Leu 165 170 175 180 gat gga ggc act att aaa att ccc gaa tgt att cac ctc tct tcc ctc 811 Asp Gly Gly Thr Ile Lys Ile Pro Glu Cys Ile His Leu Ser Ser Leu 185 190 195 cca gaa cca ctt cta cat cag act caa tca gct ctt tct ttg att tta 859 Pro Glu Pro Leu Leu His Gln Thr Gln Ser Ala Leu Ser Leu Ile Leu 200 205 210 cac cca gat ttg gaa gta gca gat cat gct ttt cct cct cca cga aca 907 His Pro Asp Leu Glu Val Ala Asp His Ala Phe Pro Pro Pro Arg Thr 215 220 225 gct tta tcc cac tca aaa atg ctg gat aaa gag gtg cga gcc gtt ttc 955 Ala Leu Ser His Ser Lys Met Leu Asp Lys Glu Val Arg Ala Val Phe 230 235 240 ctt aga tta ttt gca caa ctc ttc caa gga tat aga tcc tgc ctg caa 1003 Leu Arg Leu Phe Ala Gln Leu Phe Gln Gly Tyr Arg Ser Cys Leu Gln 245 250 255 260 ctt ata aga att cat gca gag cca gta ata cat ttc cac aag aca gca 1051 Leu Ile Arg Ile His Ala Glu Pro Val Ile His Phe His Lys Thr Ala 265 270 275 ttc ttg ggg cag cgt ggt ttg gtc gag aat gat ttc ctc act aaa gta 1099 Phe Leu Gly Gln Arg Gly Leu Val Glu Asn Asp Phe Leu Thr Lys Val 280 285 290 ctc agt gga atg gca ttt gca ggt ttt gtt tca gaa aga ggt cct cct 1147 Leu Ser Gly Met Ala Phe Ala Gly Ph e Val Ser Glu Arg Gly Pro Pro 295 300 305 tat aga tct tgt gat ctc ttt gat gag ttg gta gcc ttt gaa gta gag 1195 Tyr Arg Ser Cys Asp Leu Phe Asp Glu Leu Val Ala Phe Glu Val Glu 310 315 320 aga att aaa gtt gaa gaa aat aac cca gtg aag atg ata aag cat gtc 1243 Arg Ile Lys Val Glu Glu Asn Asn Pro Val Lys Met Ile Lys His Val 325 330 335 340 agg gaa ctt gct gag caa cta ttc aaa aat gag aat cca aat ccat 1291 Arg Glu Leu Ala Glu Gln Leu Phe Lys Asn Glu Asn Pro Asn Pro His 345 350 355 atg gca ttc cag aaa gtt cca cgg cca aca gaa gga tcc cat ttg cga 1339 Met Ala Phe Gln Lys Val Pro Arg Pro Thr Glu Gly Ser His Leu Arg 360 365 370 gtt cat att ctt cct ttc cca gag att aat gaa gcc cgg gtt cag gaa 1387 Val His Ile Leu Pro Phe Pro Glu Ile Asn Glu Ala Arg Val Gln Glu 375 380 385 385 tta ata cag gaa aat gtt gct aag aac cag aat gca cct cct gcc aca 1435 Leu Ile Gln Glu Asn Val Ala Lys Asn Gln Asn Ala Pro Pro Ala Thr 390 395 400 cga ata gaa aag aaa tgt gtt gtg cca gca ggt cca cct gtt gtt tcg 1483 Arg Ile Glu Lys Lys Cys Val Val Pro Ala Gly Pro Pro Val Val Ser 405 410 415 420 ata atg gac aag gtg acg aca gtt ttc aac agt gca caa aga cta gaa 1531 Ile Met Asp Lys Val Thr Thr Val Phe Asn Ser Ala Gln Arg Leu Glu 425 430 435 gtt gtc aga aac tgt atc tca ttc ata ttt gaa aat aaa att ttg gaa 1579 Val Val Arg Asn Cys Ile Ser Phe Ile Phe Glu Asn Lys Ile Leu Glu 440 445 450 act gaa aag acc ctt cct gct gca ccc g aaa gga aag gca 1627 Thr Glu Lys Thr Leu Pro Ala Ala Leu Arg Ala Leu Lys Gly Lys Ala 455 460 465 gca aga cag tgt ctc act gat gaa ttg ggt ttg cat gtc cag caa aac 1675 Ala Arg Gln Cys Leu Thr Asp Glu Gly Leu His Val Gln Gln Asn 470 475 480 cgg gca ata tta gac cat caa cag ttt gac tac ata ata agg atg atg 1723 Arg Ala Ile Leu Asp His Gln Gln Phe Asp Tyr Ile Ile Arg Met Met 485 490 495 500 aat tgt act cta cag gat tgt tca agt tta gaa gaa tac aac att gcc 1771 Asn Cys Thr Leu Gln Asp Cys Ser Ser Leu Glu Glu Tyr Asn Ile Ala 505 510 515 gca gca tta ctc cct ttg acc agt gct ttc tat agg aaa ctt gcc ct 1819 Ala Ala Leu Leu Pro Leu Thr Ser Ala Phe Tyr Arg Lys Leu Ala Pro 520 525 530 gga gtc agc cag ttt gct tac acg tgt gta caa gac cac ccc att tgg 1867 Gly Val Ser Gln Phe Ala Tyr Thr Cys Val Gln Asp His Pro Ile Trp 535 540 545 aca aat cag caa ttt tgg gag aca acc ttt tac aat gca gtg cag gaa 1915 Thr Asn Gln Gln Phe Trp Glu Thr Thr Phe Tyr Asn Ala Val Gln Glu 550 555 560 cag gtt cgc tcc ctt tat ctc tca gcc aag gaa gac aat cat gcc ccg 1963 Gln Val Arg Ser Leu Tyr Leu Ser Ala Lys Glu Asp Asn His Ala Pro 565 570 575 580 cat ctg aag caa aag gat aag ctt cct gat gac cat tat cag gag aag 2011 His Leu Lys Gln Lys Asp Lys Leu Pro Asp Asp His Tyr Gln Glu Lys 585 590 595 aca gca atg gac ctg gca gct gag caa cta cgc ctt tgg cct acc ctg 2059 Thr Ala Met Asp Leu Ala Ala Glu Gln Leu Arg Leu Trp Pro Thr Leu 600 605 610 agc aag tca act cag caa gag cta gtg caa cat gag gaa agc act gtc 2107 Ser Lys Ser Thr Gln Gln Glu Leu Val Gln His Glu Glu Ser Thr Val 615 620 625 ttt agt cag gcc att cac ttt gca aac ctc a tg gtg aac ctg cta gtt 2155 Phe Ser Gln Ala Ile His Phe Ala Asn Leu Met Val Asn Leu Leu Val 630 635 640 cca ctc gac aca agt aaa aac aag ctc cta aga aca tca gcg cca ggt 2203 Pro Leu Asp Thr Ser Lysn Lys Leu Leu Arg Thr Ser Ala Pro Gly 645 650 655 660 660 gac tgg gag agc gga agc aac agc att gtc aca aac agt att gca gga 2251 Asp Trp Glu Ser Gly Ser Asn Ser Ile Val Thr Asn Ser Ile Ala Gly 665 670 675 agt gta gct gag agc tat gat aca gag agt ggg ttt gaa gat tca gag 2299 Ser Val Ala Glu Ser Tyr Asp Thr Glu Ser Gly Phe Glu Asp Ser Glu 680 685 690 aat act gac att gcc aat tct gtt gtg cgg ttc att acc cga ttt att 2347 Asn Thr Asp Ile Ala Asn Ser Val Val Arg Phe Ile Thr Arg Phe Ile 695 700 705 gac aaa gtt tgt aca gag agt gga gtt act cag gat cac atc aag agc 2395 Asp Lys Val Cys Thr Glu Ser Gly Val Thr Gln Asp His Ile Lys Ser 710 715 720 ctt cat tgc atg ata cca gga att gta gct atg cac att gag acc cta 2443 Leu His Cys Met Ile Pro Gly Ile Val Ala Met His Ile Glu Thr Leu 725 730 730 735 740 gaa gca gta cat cg a gaa agc aga aga ctt ccg cct att cag aag ccc 2491 Glu Ala Val His Arg Glu Ser Arg Arg Leu Pro Pro Ile Gln Lys Pro 745 750 755 aag att ctt aga cct gct ctg ctg cca gga gaa gaa att gtc tgt gag Ile Leu Arg Pro Ala Leu Leu Pro Gly Glu Glu Ile Val Cys Glu 760 765 770 ggt ctt cga gtc ttg ctg gat cct gat gga aga gaa gaa gct act gga 2587 Gly Leu Arg Val Leu Leu Asp Pro Asp Gly Arg Glu Glu Alu Thr Gly 775 780 785 ggt ctt ctt gga ggc cct cag ctc ctg cca gca gaa gga gcc ttg ttc 2635 Gly Leu Leu Gly Gly Pro Gln Leu Leu Pro Ala Glu Gly Ala Leu Phe 790 795 800 ctc acc aca tac aga att gc aca ccc cat gat cag tta 2683 Leu Thr Thr Tyr Arg Ile Leu Phe Arg Gly Thr Pro His Asp Gln Leu 805 810 815 820 gtg ggt gag cag aca gtt gtg cgg agc ttt ccc att gcc tcc atc acc 2731 Val Gly Glu Gln Thr Val Val Arg Ser Phe Pro Ile Ala Ser Ile Thr 825 830 835 aag gag aag aag att aca atg cag aac cag cta cag cag aac atg caa 2779 Lys Glu Lys Lys Ile Thr Met Gln Asn Gln Leu Gln Gln Asn Met Gln 840 845 850 gaa gga ctg cag atc aca tca gca tct ttt cag ttg att aag gta gca 2827 Glu Gly Leu Gln Ile Thr Ser Ala Ser Phe Gln Leu Ile Lys Val Ala 855 860 865 ttt gat gaa gaa gtc agt cca gaa gta gtag gag atg aaa cag 2875 Phe Asp Glu Glu Val Ser Pro Glu Val Val Glu Ile Phe Lys Lys Gln 870 875 880 ctg atg aag ttc cgt tat cct cag tcc att ttc agt acc ttt gct ttt 2923 Leu Met Lys Phe Arg Tyr Pro Gln Ser Ile Phe Ser Thr Phe Ala Phe 885 890 895 900 gct gct gga caa act acc cca caa ata att tta cca aaa cag aag gaa 2971 Ala Ala Gly Gln Thr Thr Pro Gln Ile Ile Leu Pro Lys Gln Lys Glu 905 910 915 aag aac act tct ttt cgt acc ttc tca aaa aca att gtg aaa ggt gcc 3019 Lys Asn Thr Ser Phe Arg Thr Phe Ser Lys Thr Ile Val Lys Gly Ala 920 925 930 930 aaa agg gca ggg aaa atg aca att ggg cgg caa tat tta ctg aag aag 3067 Lys Arg Ala Gly Lys Met Thr Ile Gly Arg Gln Tyr Leu Leu Lys Lys 935 940 945 aag aca ggg aca att gtg gaa gaa aga gta aat cgt cct gga tgg aat 3115 Lys Thr Gly Thr Ile Val Glu Glu Arg Val Asn Arg Pro Gly Trp Asn 950 955 960 gaa gat gat gat gta tct gtt tca gat gag agt gag ctc ccc aca agt 3163 Glu Asp Asp Asp Val Ser Val Ser Asp Glu Ser Glu Leu Pro Thr Ser 965 970 975 975 980 acc acc ctg aag gcc tcc gag aag tct aca atg gaa cag ttg gtg gaa 3211 Thr Thr Leu Lys Ala Ser Glu Lys Ser Thr Met Glu Gln Leu Val Glu 985 990 995 aaa gct tgt ttc aga gac tat cag cgt tta ggt tta gga acc ata agt 3259 Lys Ala Cys Phe Arg Asp Tyr Gln Arg Leu Gly Leu Gly Thr Ile Ser 1000 1005 1010 ggc agc tct tcc cgt tca aga ccc gag tat ttt aga att act gcc tcc 3307 Gly Ser Ser Ser Arg Ser Arg Pro Glu Tyr Phe Arg Ile Thr Ala Ser 1015 1020 1025 aac agg atg tat tca ctc tgc cgg agg taagtgtgtc agtgggctcc 3354 Asn Arg Met Tyr Ser Leu Cys Arg Arg 1030 1035 aaaaagaggt cttctttcct ttcttcttat ttgaatcttt aataggccat ttgcatccat 3414 agccctgaga tagataaaaa tgcctgaaaa taagaacaag gtctccagga tacgagcaag 3474 catctcattg gcattctcgg aacaattacc ttactgaaag tacctctagt aggtgagaag 3534 gtgaaaggta aagtactcac cccctatgaa tttctcttgt ctttctcttc ccagtttgct Three 594 tcttttctag catgactaaa gataacttga agaacaggat tttcccagcc caatagagga 3654 catgaaagtc ttttgtaggc tggggagcca caaactcttt ctataaaggg tcagttggta 3714 aatattttca gtttatgagc catagagtct cttgttgcag ctattcaact gtgccgcaaa 3774 agcagccaca gacagtaagg aaatgagtag gcatggccag ttttggccca caggctataa 3834 tttgctgacc caggtgtagg caaggctttc ttatgcggtc taattggaat gttttcaagg 3894 gaatattact taaaggatgt aaataaagag gcattttctt ttttcagttc ttgtcatctc 3954 tcactgtttt tcaaatatgt tgagtcttat tccatgcttt actatatgta aatatatatt 4014 ttctaaaatt acattttcac catccacaag tttagtcatt ttcatctcca ggtaagattt 4074 ttctttgcat ttataaattc ctgcttaaac agctctgaaa tcactttgta aattgtaagc 4134 tttgtacata ttttagaaag ttatcttaat gttactttca accctgttgc tcttgaagat 4194 agatatgtca ttttaaatgg caatttaagt ttacaaatat taatatgaaa cttcagaaac 4254 aagttgggaa tatagttttg agattgtggc caaataaaca ttttgcatga agttctgaaa 4314 aattggcact ctgagtatgc agtaattttt ctggaattct ccgtcattct aactaaattt 4374 tctctgaaga tgagtcatgt tgtcggggtg tgatgtcctg ctgtttggaa agtttgctat 4434 ca aaattatg ccagccattg agaaaacaga ctcatttatc attccaatct gtcagaagta 4494 aaataaaatt ttaatagatg acttattaga acactggtta taaagcattt atgatggtaa 4554 aaagtaatat atatccatta agttattagc aggaaggaaa tggaataata aaaaataatc 4614 caaaagaagg caagaaagga aaaaaaaggg gacatagaac aaatggaata aataacaagt 4674 agtaagatgg tagatttaaa ttcaaatata tccataattg cattaattat taattgacta 4734 aatgttccaa ttcaaagaaa gagatcaggg tttgcttt 4772 <210> 139 <211> 4701 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3497) <400> 139 ta gaa gct ggt tct gca gac atg tcc aaa aac atc att atg cct gaa 47 Glu Ala Gly Ser Ala Asp Met Ser Lys Asn Ile Ile Met Pro Glu 1 5 10 15 gaa gag cat caa caa aat tct gag gaa ttt caa ata att tca ggt caa 95 Glu Glu His Gln Gln Asn Ser Glu Glu Phe Gln Ile Ile Ser Gly Gln 20 25 30 cca tct gat act ctt aaa tct aga aat gct gca gat tgc tct att tta 143 Pro Ser Asp Thr Leu Lys Ser Arg Asn Ala Ala Asp Cys Ser Ile Leu 35 40 45 aat gag aat act aat tta gat atg tct aaa gtg ctc tgc gct gct gac 191 Asn Glu Asn Thr Asn Leu Asp Met Ser Lys Val Leu Cys Ala Ala Asp 50 55 60 tct gta gaa gtt gag act gaa gaa gaa tct aat ttc aat gaa gac cat 239 Ser Val Glu Val Glu Thr Glu Glu Glu Ser Asn Phe Asn Glu Asp His 65 70 75 tcc ttt tgt gag act ttc caa cag gct cct gtc aag gat aaa gtt agg 287 Ser Phe Cys Glu Thr Phe Gln Gln Ala Pro Val Lys Asp Lys Val Arg 80 85 90 95 aaa cct gag gag atg atg tca ctt act atg tcc tca aac tat ggc tcc 335 Lys Pro Glu Glu Met Met Ser Leu Thr Met Ser Ser Asn Tyr Gly Ser 100 105 110 cca agc aga ttt caa aat gaa aat tca gga agc tct gcc tta aat tgt 383 Pro Ser Arg Phe Gln Asn Glu Asn Ser Gly Ser Ser Ala Leu Asn Cys 115 120 125 gag aca gca aag aaa aac cat gag ata tcg aat gat gca ggt gag ctg 431 Glu Thr Ala Lys Lys Asn His Glu Ile Ser Asn Asp Ala Gly Glu Leu 130 135 140 cgt gtc cat tgt gag ggt gaa gga gga aac gca gga gac ggt gga ggt 479 Arg Val His Cys Glu Gly Glu Gly Gly Asn Ala Gly Asp Gly Gly Gly 145 150 155 gtt gtc ccc cac aga cac ctg tgc cct gtg acg ctc gat ggg gag cgc 527 Val Val Pro His Arg His Leu Cys Pro Val Thr Leu Asp Gly Glu Arg 160 165 170 175 tcg gct gaa agc cgt ctc gtt gtg aca aga ata acc aga gaa cag 575 Ser Ala Glu Ser Pro Val Leu Val Val Thr Arg Ile Thr Arg Glu Gln 180 185 190 gga aat ctg gag agc ggg ggt cag aac aga gtt gca cgt ggg cat ggt 623 Gly Asn Leu Glu Ser Gly Gly Gln Asn Arg Val Ala Arg Gly His Gly 195 200 205 ttg gaa gac ttg aaa ggt gtc caa gaa gat ccc gtt ctg ggg aat aag 671 Leu Glu Asp Leu Lys Gly Val Gln Glu Asp Pro Val Leu Gly Asn Lys 210 215 220 gaa att ctg atg aat tca caa cat gaa aca gaa ttt att ttg gag gag 719 Glu Ile Leu Met Asn Ser Gln His Glu Thr Glu Phe Ile Leu Glu Glu 225 230 235 gat ggc cca gct tct gat agc aca ggta gat gtc tat gaa 767 Asp Gly Pro Ala Ser Asp Ser Thr Val Glu Ser Ser Asp Val Tyr Glu 240 245 250 255 act ata att agt att gat gat aaa ggg cag gcc atg tac agt ttt ggt 815 Thr Ile Ile Ser Ile Asp Asp Lys Gly Gln Ala Met Tyr Ser Phe Gly 260 265 270 270 cga ttt gac tcc tcc ata ata aga ata aag aac cct gaa gat ggt gag 863 Arg Phe Asp Ser Ser Ile Ile Arg Ile Lys Asn Pro Glu Asp Gly Glu 275 280 280 285 ttg ata gac cag tct gaa gag ggc ttg ata gca acg gga gtg aga att 911 Leu Ile Asp Gln Ser Glu Glu Gly Leu Ile Ala Thr Gly Val Arg Ile 290 295 300 agt gag ctg ccc ttg aaa gac tgt gct caa ggt gtg aaa aag Ser Glu Leu Pro Leu Lys Asp Cys Ala Gln Gly Val Lys Lys Lys Lys 305 310 315 tct gag ggc agt tcc att ggt gag tct aca cga att cgc tgt gat gat 1007 Ser Glu Gly Ser Ser Ile Gly Glu Ser Thr Arg Ile Arg Cy s Asp Asp 320 325 330 335 tgt ggc ttc tta gca gat gga ctg agt gga ctg aat gtt cac ata gcc 1055 Cys Gly Phe Leu Ala Asp Gly Leu Ser Gly Leu Asn Val His Ile Ala 340 345 350 atg aag cat cct aca aaa gag aag cac ttc cat tgt tta ctc tgt gga 1103 Met Lys His Pro Thr Lys Glu Lys His Phe His Cys Leu Leu Cys Gly 355 360 365 aag tcg ttc tat acc gaa agc aac ctt cac cag cat ctg gct agt gcc 1151 Lys Ser Phe Tyr Thr Glu Ser Asn Leu His Gln His Leu Ala Ser Ala 370 375 380 ggc cac atg aga aat gag cag gcc agt gtg gag gag ctt ccg gag gga 1199 Gly His Met Arg Asn Glu Gln Ala Ser Val Glu Glu Leu Pro Glu Gly 385 390 395 ggg gcc acc ttt aaa tgt gtc aag tgc aca gag ccc ttt gat tct gaa 1247 Gly Ala Thr Phe Lys Cys Val Lys Cys Thr Glu Pro Phe Asp Ser Glu 400 405 410 415 cag aat tta ttt cta cat att aaa gga cag cat gag gaa ttg ctg cgg 1295 Gln Asn Leu Phe Leu His Ile Lys Gly Gln His Glu Glu Leu Leu Arg 420 425 430 gag gtg aat aag tat ata gtg gaa gac act gag caa atc aac cgc gag 1343 Glu Val Asn Lysl Tyr Ile G u Asp Thr Glu Gln Ile Asn Arg Glu 435 440 445 agg gag gaa aac cag gga aac gtc tgc aag tat tgt ggg aag atg tgt 1391 Arg Glu Glu Asn Gln Gly Asn Val Cys Lys Tyr Cys Gly Lys Met Cys 450 455c cga agc aac tcg atg gcc ttc ctg gca cac att cgc act cac aca 1439 Arg Ser Ser Asn Ser Met Ala Phe Leu Ala His Ile Arg Thr His Thr 465 470 470 475 gga tca aaa cca ttc aag tgc aag ata tgc cat tttgca aca gct 1487 Gly Ser Lys Pro Phe Lys Cys Lys Ile Cys His Phe Ala Thr Ala Gln 480 485 495 ctt gga gat gcc aga aac cat gtg aaa agg cac ctt ggg atg agg gaa 1535 Leu Gly Asp Ala Arg Asn His Val Lys Arg His Leu Gly Met Arg Glu 500 505 510 tac aag tgt cat gtc tgt ggg gtt gct ttt gta atg aag aag cac tta 1583 Tyr Lys Cys His Val Cys Gly Val Ala Phe Val Met Lys Lys His Leu 515 520 525 aat act cat cta cta ggc aag cat gga gtt ggc acc cca aaa gaa agg 1631 Asn Thr His Leu Leu Gly Lys His Gly Val Gly Thr Pro Lys Glu Arg 530 535 540 aaa ttt aca tgc cac tta tgt gat aga agt ttc aca gag aag tgg gcc 1679 Lys Phe Thr Cys His Leu Cys Asp Arg Ser Phe Thr Glu Lys Trp Ala 545 550 555 ctg aac aac cac atg aaa ctc cac acg gga gaa aag ccg ttt aaa tgt 1727 Leu Asn Asn His Met Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys 560 565 570 575 acc tgg ccc acg tgc cat tac tca ttc ctc aca gcc tcc gca atg aaa 1775 Thr Trp Pro Thr Cys His Tyr Ser Phe Leu Thr Ala Ser Ala Met Lys 580 585 590 590 gac cac tac agg acg cac aca ggc gag aag tcg ttt ctg tgt gac ctc 1823 Asp His Tyr Arg Thr His Thr Gly Glu Lys Ser Phe Leu Cys Asp Leu 595 600 605 tgc ggc ttt gcc ggc ggg acc cgc cac gcc ctc acc aag cat cgc aga 1871 Cys Gly Phe Ala Gly Gly Thr Ar His Ala Leu Thr Lys His Arg Arg 610 615 620 cag cac aca gga gaa aaa cct ttc aag tgc gat gag tgt aac ttt gcc 1919 Gln His Thr Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Asn Phe Ala 625 630 630 tcc aca act cag tcc cat ttg act cgg cat aaa cgt gtc cac act gga 1967 Ser Thr Thr Gln Ser His Leu Thr Arg His Lys Arg Val His Thr Gly 640 645 650 655 gaa aag ccc tac aga tgc ccc tgg tgt gac tac agg tca aac t gt gct 2015 Glu Lys Pro Tyr Arg Cys Pro Trp Cys Asp Tyr Arg Ser Asn Cys Ala 660 665 670 gaa aat atc cgc aaa cac att ctg cat act ggc aaa cat gaa gga gtc 2063 Glu Asn Ile Arg Lys His Ile Leu His Thr Gly Lys His Glu Gly Val 675 680 685 aag atg tac aac tgt ccc aag tgt gac tac ggg acc aac gtc ccg gtg 2111 Lys Met Tyr Asn Cys Pro Lys Cys Asp Tyr Gly Thr Asn Val Pro Val 690 695 700 gag ttc cgg aac cat ttg aag gaa cag cat cct gac atc gaa aac ccg 2159 Glu Phe Arg Asn His Leu Lys Glu Gln His Pro Asp Ile Glu Asn Pro 705 710 715 gac ctc gct tac ctg cat gct ggc att gtt tcc aag tcg tac gag tgc A207 Asp Tyr Leu His Ala Gly Ile Val Ser Lys Ser Tyr Glu Cys 720 725 730 735 cgt cta aag gga caa gga gcc acc ttc gtg gag aca gac agc ccc ttc 2255 Arg Leu Lys Gly Gln Gly Ala Thr Phe Val Glu Thr Asp Ser Pro Phe 740 745 750 acc gcg gcg gcc ttg gca gaa gag ccc ctc gtc aag gag aag ccc ctc 2303 Thr Ala Ala Ala Leu Ala Glu Glu Pro Leu Val Lys Glu Lys Pro Leu 755 760 765 aga agc agc agg gg cca gcgg ct gag cag gtg cag cag gtc 2351 Arg Ser Ser Arg Arg Pro Ala Pro Pro Pro Glu Gln Val Gln Gln Val 770 775 780 atc atc ttc cag ggc tac gac ggg gag ttt gcc ctg gac ccc tcg gtg 2399 Ile Ile Phe Gln Gly Asp Gly Glu Phe Ala Leu Asp Pro Ser Val 785 790 790 795 gag gag acg gcc gcc gcc acg ctg cag acg ctg gcc atg gcc ggc cag 2447 Glu Glu Thr Ala Ala Ala Thr Leu Gln Thr Leu Ala Met Ala Gly Gln 800 805 810 815 gtg gcc cgg gtg gtg cat atc acg gag gat ggc cag gtc atc gcc acg 2495 Val Ala Arg Val Val His Ile Thr Glu Asp Gly Gln Val Ile Ala Thr 820 825 830 agt cag agc ggg gca cat gta ggc agc gtg ccg gcc atc ctc 2543 Ser Gln Ser Gly Ala His Val Gly Ser Val Val Pro Gly Pro Ile Leu 835 840 845 ccc gag cag ctg gct gat gga gcc acc cag gtg gtc gtc gtg ggg ggc 2591 Pro Glu Gln Leu Ala Asp Gly Ala Thr Gln Val Val Val Val Gly Gly 850 855 860 tcc atg gaa ggc cac ggc atg gat gag tcc ctc agt cca ggt ggc gct 2639 Ser Met Glu Gly His Gly Met Asp Glu Ser Leu Ser Pro Gly Gly Ala 865 870 875 875 gtg ata caa cag gt g acc aag cag gag att tta aac ctc tcg gag gct 2687 Val Ile Gln Gln Val Thr Lys Gln Glu Ile Leu Asn Leu Ser Glu Ala 880 885 890 895 gga gtc gct ccc ccc gag gca tcc tca gcc ctg gat gca ttg ctc tgt Gly Val Ala Pro Pro Glu Ala Ser Ser Ala Leu Asp Ala Leu Leu Cys 900 905 910 gcg gtc act gaa tta ggg gag gtg gag ggc agg gct ggg ctc gag gag 2783 Ala Val Thr Glu Leu Gly Glu Val Glu Gly Arg Ala Gly Leu Glu Glu 915 920 925 caa ggc agg ccc ggc gcc aaa gac gtg ctg atc cag ctg ccc ggg cag 2831 Gln Gly Arg Pro Gly Ala Lys Asp Val Leu Ile Gln Leu Pro Gly Gln 930 935 940 gag gtc tcc cat gc gcc gag gcc ccc gag atc cag atg 2879 Glu Val Ser His Val Ala Ala Asp Pro Glu Ala Pro Glu Ile Gln Met 945 950 955 ttc cca cag gcc cag gag agc ccg gcc gcc gtg gag gtg ctc acc cag 2927 Phe Pro Gln Ala Gln Ser Pro Ala Ala Val Glu Val Leu Thr Gln 960 965 970 975 gtg gtc cat ccc tca gca gcc atg gcc tct cag gag cgg gca cag gtg 2975 Val Val His Pro Ser Ala Ala Met Ala Ser Gln Glu Arg Ala Gln Val 980 985 990 gcc ttc aag aag atg gtc cag ggc gtc ctc cag ttt gct gtg tgt gac 3023 Ala Phe Lys Lys Met Val Gln Gly Val Leu Gln Phe Ala Val Cys Asp 995 1000 1005 acg gcc gcg gcc ggc cag ttg ggt gag ag cag gtg gtg 3071 Thr Ala Ala Ala Gly Gln Leu Val Lys Asp Gly Val Thr Gln Val 1010 1015 1020 gtg agc gaa gag ggt gcc gtc cac atg gtc gcc ggg gag ggt gcc cag 3119 Val Ser Glu Glu Gly Ala Val His Met Val Ala Gly Glu Gly Ala Gln 1025 1030 1035 atc atc atg cag gag gcg cag ggc gag cac atg gat ctg gtg gag tcc 3167 Ile Ile Met Gln Glu Ala Gln Gly Glu His Met Asp Leu Val Glu Ser 1040 1045 1050 1055gac ggg tcg cag atc atc gtg aca gag gag ctg gtc cag gcc 3215 Asp Gly Glu Ile Ser Gln Ile Ile Val Thr Glu Glu Leu Val Gln Ala 1060 1065 1070 atg gtg cag gag tcc agt ggc ggc ttc tcc gag ggc acc acg Mac Val Gln Glu Ser Ser Gly Gly Phe Ser Glu Gly Thr Thr His Tyr 1075 1080 1085 atc ctg aca gag ctg ccc cca ggg gtg cag gac gag ccg ggc ctg tac 3311 Ile Leu Thr Glu Leu Pro Pro Gly Va l Gln Asp Glu Pro Gly Leu Tyr 1090 1095 1100 tcc cac acc gtg ctg gag act gcg gac tcg cag gaa ctc ctg cag gcc 3359 Ser His Thr Val Val Leu Glu Thr Ala Asp Ser Gln Glu Leu Leu Gln Ala 1105 1110 1115 ggg gcc ac cta ggc aca gag gcc ggg gcc cca agc agg gca gag cag 3407 Gly Ala Thr Leu Gly Thr Glu Ala Gly Ala Pro Ser Arg Ala Glu Gln 1120 1125 1130 1135 ctg gcc agc gtg gtc atc tac acc cag gag ggc tcc gc gg 3455 Leu Ala Ser Val Val Ile Tyr Thr Gln Glu Gly Ser Ser Ala Ala Ala 1140 1145 1150 gca att cag agc caa aga gaa agc agc gaa ctc cag gaa gca 3497 Ala Ile Gln Ser Gln Arg Glu Ser Ser Glu Leu Gln Glu 1155 1160 1165 tgagacgcgc ggcaccttta ctcagcacag ggcaggtgtg ggaaggtcca gcttcggtgg 3557 gggaccgtgt tccctgagct tcatctgaaa ccttcaaaac catgaggaca aggctcccgt 3617 gagctctgag catgccctcc cagcgagagt cacactggcc accagccagg cgcccacaga 3677 gggtaccgtg ggctgggcct cggggagcag gctgccaagt gcaggggagg gccgggcgca 3737 ggccacacag ggagctccgg tccactgggg gcccttcgat cagtggcctc ccgcttcgtc 3797 ctggccgctg tgctgaa gag aagccaagtg ttgttggtgt ttttctctcc caagtgtttt 3857 cccatttcag ttatcagaag gtcatggccg tggggaaagt ggtgaagata cccctcgtgg 3917 cttggggtgc acctgcttgt gcagtcagca tgtagctgcc tttccatttc attctctact 3977 gggctaaaaa ttgcagctac aagtgttacc atcttgaagc agtccacttc cattcaattt 4037 ttttttttta attttagaat aacagtgtcc ccataccaaa ggaagcctgc tagctcattt 4097 catgtataaa tttcccatct tcaaacagtt taggtgtatt tgttgctctg gtcacattct 4157 gcataaaaga aatcctctta agcctatggt taagaaaagc cttgaagttt atattcagtt 4217 aaaatatatg tcggtggaga tagccagtgc ttctaatttt gacttagttt catacagtaa 4277 agcctaaatg tgaaacgcac acgctggaag atattgttcc tatcaatatt ttgcttttta 4337 taacaagggt ttgttcatat tgatgccatt tttgcaggat ttcttcgtga tttctgtcca 4397 tatgaaaatg ctgacattaa acattaacac atggagaccg tgccctgtgg ccctgccgtg 4457 gctgccagca tggtctgtgt ttccttgtgg attcacctgt ggccctgctg tggccaccag 4517 catggtctgt gtcctcgtgg attcactgca gctgtcggat gcgagtttct gtcataatca 4577 tttgtttcct gatacaattg ttcttattct tttccaaaac tgtaaaataa tctcctccct 4637 caaatgcaaa ggttgttttt gt tctgtttc tgttttcttt gaaataaaat tataacgtta 4697 aaag 4701 <210> 140 <211> 3949 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1714) .. (3207) <400> 140 gccattccct gtagcaggat taatcattta taaaataaag tccctatcca ttacttgctt 60 cacataactt tttttatgtg aaatagtgtt ttattgaatt aagttccata tctgagtttt 120 ttagataaca tattgatttt aaaatctgag tgttataatt cttcaaacaa ataaagtttg 180 tcttggagac cttcaaatta gcttttcctt tttgcaatag ctgttcatag tttcaagttg 240 agtcgaaacc atgtggactg gcacagtgtg gatgaagtat atctttatag tgatgcaaca 300 acatctaaaa ttgcaagaac agttacccaa aaactgggat tttctaaagg taattgttaa 360 atattactag agcttatcaa aattttggga atctgacttt ctctcatatt caaaatagac 420 aattcatatt ctgtttttag tatgttttaa gtatattaaa tttagtgaca gattcctttt 480 taaatgaaac ttttattaag ttgattgagt tgacatgtgt tcatcaagga ataattatta 540 tatatttaga atgatttgac aaaattaata aatatctttt atacttctaa aagcacaaaa 600 gctgttaaac ctaaaatgtg gcagttgaaa tatagtgtca aggaagatga ggactgaaag 660 ttttccattg tatttagtga tctggaggtc actggtgact tagatggatt gatggggcag 720 aaaccagatc agcatgggtt gaagcgtaaa tagaaggtga agcaatggaa gcaatgagaa 780 tagacaactc cttttttttt ttcttctttt atttttaaga tggggtctca ctctgtctcc 840 caggctggag tacagtggtg tgatcatagc acatcataac ctggaactaa ttcctgggct 900 caagcaatcc tccaaactca gcctcctcag taactaggat tacagggatg catcactatg 960 cccagctaat tttttttatt tttttgtaga aacggagtct ccttgtgttg tccaggctgg 1020 tctcaaattt ttgggcacaa gccatcctct cgccttggtc tcccaaagct ctggggttac 1080 aggcttgaaa tacagtgcct ggcctgacaa ctgtttagag aagtttgact aaatgaaaga 1140 aaagagagaa tgatacctgg gaaagatgtg agagcattat caaaaaataa atgtaaaaag 1200 aattttaaag tttgataaaa tttttatatc ctattttaaa attttaattt catcaataag 1260 tgtgctttga atatcttttt atgtttatta gttatattta ttttgaatta ccttccataa 1320 ctttaactta ttttgctatt tgaatggttg tctttacttt ttaattagta agctctctct 1380 gtatacttaa gtaattatgt gttatatttt gcatattttt ttccagtttg ccatttcttt 1440 tttcctgata ttttcttatt ataatataga agctttaaat ttttatatat tcagtttgtc 1500 cttctttcct tccatttctt tctctttatg gtttctggct ttggtgttgt gtccagttca 1560 ctttatatca cagctgatca atatatacct tcttacagtt tttatttcct cccccacagc 1620 cagtgaaatt ttttcataat attcctttta cttctttttt ttcttttaac atattgtgga 1680 aatgctattt ctcagat taa atagtaaact tag aat tat aat ttt tct aca gca 1734 Asn Tyr Asn Phe Ser Thr Ala 15 tca agt agt ggt acc aga ctt cat aga ggt tat gta gaa gaa gcc aca 1782 Ser Ser Ser Ser Gly Thr Arg Leu His Arg Gly Tyr Val Glu Glu Ala Thr 10 15 20 tta gaa gac aag cca tca cag act acc cat att gta ttt gtt gtg cat 1830 Leu Glu Asp Lys Pro Ser Gln Thr Thr His Ile Val Phe Val Val His 25 30 35 ggc att ggg cag aaa atg gac caa gga aga att atc aaa aat aca gct 1878 Gly Ile Gly Gln Lys Met Asp Gln Gly Arg Ile Ile Lys Asn Thr Ala 40 45 50 55 atg atg aga gaa gct gca aga aaa ata gaa gaa agg cat ttt tcc aac 1926 Met Met Arg Glu Ala Ala Arg Lys Ile Glu Glu Arg His Phe Ser Asn 60 65 70 cat gca aca cat gtt gaa ttt ctg cct gtt gag tgg cgg tca aaa ctt 1974 His Ala Thr His Val Glu Phe Leu Pro Val Glu Trp Arg Ser Lys Leu 75 80 85 act ctt gat gga gac act gtt gat tcc att act cct gac aaa gta cga 2022 Thr Leu Asp Gly Asp Thr Val Asp Ser Ile Thr Pro Asp Lys Val Arg 90 95 100 ggt tta agg gat atg ctg aac agc agt gca atg gac ata atg tat tat 2070 Gly Leu Arg Asp Met Leu Asn Ser Ser Ala Met Asp Ile Met Tyr Tyr 105 110 115 act agt cca ctt tat aga gat gaa cta gtt aaa ggc ctt cag caa gag 2118 Thr Ser Pro Leu Tyr Arg Asp Glu Leu Val Lys Gly Leu Gln Gln Glu 120 125 130 135 ctg aat cga ttg tat tcc ctt ttc tgt tct cgg aat cca gac ttt gaa 2166 Leu Asn Arg Leu Tyr Ser Leu Phe Cys Ser Arg Asn Pro Asp Phe Glu 140 145 150 gaa aaa ggg ggt aaagtc tca ata gta tca cat tcc ttg gga tgt gta 2214 Glu Lys Gly Gly Lys Val Ser Ile Val Ser His Ser Leu Gly Cys Val 155 160 165 att act tat gac ata atg act ggc tgg aat cca gtt cgg ctg tat gaa 2262 Ile Thr Tyr Asp Ile Met Thr Gly Trp Asn Pro Val Arg Leu Tyr Glu 170 175 180 cag ttg ctg caa aag gaa gaa gag ttg cct gat gaa cga tgg atg agc 2310 Gln Leu Leu Gln Lys Glu Glu Glu Leu Pro Asp Glu Arg Trp Ser 190 195 tat gaa gaa cga cat ctt ctt gat gaa ctc tat ata aca aaa cga cgg 2358 Tyr Glu Glu Arg His Leu Leu Asp Glu Leu Tyr Ile Thr Lys Arg Arg 200 205 210 215 ctg aag gaa ata gaa gaa cgg ctt g ga ttg aaa gca tca tct atg 2406 Leu Lys Glu Ile Glu Glu Arg Leu His Gly Leu Lys Ala Ser Ser Met 220 225 230 aca caa aca cct gcc tta aaa ttt aag gtt gag aat ttc ttc tgt atg 2454 Thr Gln Thr Pro Ala Leu Lys Phe Lys Val Glu Asn Phe Phe Cys Met 235 240 245 gga tcc cca tta gca gtt ttc ttg gcg ttg cgt ggc atc cgc cca gga 2502 Gly Ser Pro Leu Ala Val Phe Leu Ala Leu Arg Gly Ile Arg Pro Gly 250 255 260 aat act gga agt caa gac cat att ttg cct aga gag att tgt aac cgg 2550 Asn Thr Gly Ser Gln Asp His Ile Leu Pro Arg Glu Ile Cys Asn Arg 265 270 275 tta cta aat att ttt cat cct aca gat cca gtg gct tat aga tta gaa 2598 Leu Leu Asn Ile Phe His Pro Thr Asp Pro Val Ala Tyr Arg Leu Glu 280 285 290 295 cca tta ata ctg aaa cac tac agc aac att tca cct gtc cag atc cac 2646 Pro Leu Ile Leu Lys His Tyr Ser Asn Ile Ser Pro Val Gln Ile His 300 305 310 tgg tac aat act tca aat cct tta cct tat gaa cat atg aag cca agc 2694 Trp Tyr Asn Thr Ser Asn Pro Leu Pro Tyr Glu His Met Lys Pro Ser 315 320 325 ttt ctc aac cca g ct aaa gaa cct acc tca gtt tca gag aat gaa ggc 2742 Phe Leu Asn Pro Ala Lys Glu Pro Thr Ser Val Ser Glu Asn Glu Gly 330 335 340 att tca acc ata cca agc cct gtg acc tca cca gtt ttg tcc cgc cga 2790 Ile Ser Thr Ile Pro Ser Pro Val Thr Ser Pro Val Leu Ser Arg Arg 345 350 355 cac tat gga gaa tct ata aca aat ata ggc aaa gca agc ata tta ggg 2838 His Tyr Gly Glu Ser Ile Thr Asn Ile Gly Lys Ala Ser Ile Leu Gly 360 365 370 375 gct gct agc att gga aag gga ctt gga gga atg ttg ttc tca aga ttt 2886 Ala Ala Ser Ile Gly Lys Gly Leu Gly Gly Met Leu Phe Ser Arg Phe 380 385 390 gga cgt tca tct aca aca cag tca gaa aca tca aaa gac tca atg 2934 Gly Arg Ser Ser Thr Thr Gln Ser Ser Glu Thr Ser Lys Asp Ser Met 395 400 405 gaa gat gag aag aag cca gtt gcc tca cct tct gct acc acc gta ggg 2982 Glu Asp Glu Lys Lys Pro Val Ala Ser Pro Ser Ala Thr Thr Val Gly 410 415 420 aca cag acc ctt cca cat agc agt tct ggc ttc ctc gat tct gca ttg 3030 Thr Gln Thr Leu Pro His Ser Ser Ser Gly Phe Leu Asp Ser Ala Leu 425 430 43 5 gag ttg gat cac agg att gat ttt gaa ctc aga gaa ggc ctt gtg gag 3078 Glu Leu Asp His Arg Ile Asp Phe Glu Leu Arg Glu Gly Leu Val Glu 440 445 445 450 455 agc cgc tat tgg tca gc gc gcc gcc tat tgg tca tcc 3126 Ser Arg Tyr Trp Ser Ala Val Thr Ser His Thr Ala Tyr Trp Ser Ser 460 465 470 ttg gat gtt gcc ctt ttt ctt tta acc ttc atg tat aaa cat gag cac 3174 Leu Asp Val Ala Leu Phe Leu Leu Thr Phe Met Tyr Lys His Glu His 475 480 485 gat gat gat gca aaa ccc aat tta gat cca atc tgaactcttg aaggacatga 3227 Asp Asp Asp Ala Lys Pro Asn Leu Asp Pro Ile tt 490 495 atggcctaaa actgattttt tttttgg gatca tg tca tg tg tg tg tg tg 3347 tttatttaaa aaaaaaagaa gttttcagtt ctgaagaagt catttacagt ttgcatcatt 3407 ttaattatga gtctgacaaa accttctcca gagaatcaag caagacctgg atgtgaagaagg 3467 ggtttgggta aactgcatgt aaaggctaca aatcacaatc tgattcctcc tgattcctcc tgattccatc tgattcctcc tgattccatc tgattccatcc tgattccatcc tgattcctcc t atatgaagat cacaaggtgg tatcgtttta gatttctatg aaggctttca 3647 tttgtacatc cctttgaaaa aatataacag atttaaaatg ttttgaattt aacttgttta 3707 gaaaaactaa tgcttaaaac aatatttgaa ctactgtatt tataatttat tacctctaat 3767 tgctttattt cagtgtatga gacattactg ttttaatgtt tgctttgaac ataatttaag 3827 aaccagattt attttctata gtgataaacc cttttttctc agaactccat ctttgtactc 3887 ttcagatgaa tatatagaca ctgtggcata catttttttt cattaaaaac ttatggcttc 3947 at 3949 <210> 141 <211> 3745 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (74) .. (1240) <400> 141 attatggtct gtcgtgcgct gctgctgctt ttctgctcct ggaagcggcc aaggggggaa 60 gcggcgagtc aac atg gag ctt tca gcg gtg ggg gag cgg gtg ttc gcg gtc gcg 109 Met Glu Leu Ser Ala Val Gc Ag Lag Gc Ag Lag cgg aaa gga cgc atg gaa tac 157 Ala Glu Ala Leu Leu Lys Arg Arg Ile Arg Lys Gly Arg Met Glu Tyr 15 20 25 ctc gtg aaa tgg aag gga tgg tcg cag aag tac agc aca tgg gaa ccg 205 Leu Val Lys Trp Ser Gln Lys Tyr Ser Thr Trp Glu Pro 30 35 40 gag gaa aac atc ctg gat gct cgc ttg ctc gca gcc ttt gag gaa agg 253 Glu Glu Asn Ile Leu Asp Ala Arg Leu Leu Ala Ala Phe Glu Glu Arg 45 50 55 60 gaa aga gag atg gag ctc tat ggc ccc aaa aag cgt gga ccc aag ccc 301 Glu Arg Glu Met Glu Leu Tyr Gly Pro Lys Lys Arg Gly Pro Lys Pro 65 70 75 aaa acc ttc ctc ctc aaa gcg cag gcc aag gca aag gcc act tac 349 Lys Thr Phe Leu Leu Lys Ala Gln Ala Lys Ala Lys Ala Lys Thr Tyr 80 85 90 gag ttt cga agt gac tca gcc agg ggc atc cgg atc ccc tac cct ggc 397 Glu Phe Arg Ser Asp Ser Ala Arg Gly Ile Arg Ile Pro Tyr Pro Gly 95 100 105 cgc tcg ccc cag gac ctg gcc tcc act tcc cgg gcc cgg gag ggc ctt 445 Arg Ser Pro Gln Asp Leu Ala Ser Thr Ser Arg Ala Arg Glu Gly Leu 110 115 120 cga aac atg ggt ttg tcc ccg cca gcg agc agc acc agc acc agc agc 493 Arg Asn Met Gly Leu Ser Pro Pro Ala Ser Ser Thr Ser Thr Ser Ser 125 130 135 140 acc tgc cgc gca gag gcc cct cgg gac cgg gac cga gac cgg gat agg 541 Thr Cys Arg Ala Glu Ala Pro Arg Asp Arg Asp Arg Asp Arg Asp Arg 145 150 155 gac cgg gag cgg gat cga gaa agg gag agg gag cga gag agg gag cgg 589 Asp Arg Glu Arg Asp Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 160 165 170 gaa cgt gag agg gaa cga gag cgg ggt acc agc aga gtg gat gac aag 637 Glu Arg Glu Arg Glu Arg Glu Arg Gly Thr Ser Arg Val Asp Asp Lys 175 180 185 ccc agc tca ccg ggg agc tcg aag aag cga ggc ccc aag ccc cgg 685 Pro Ser Ser Pro Gly Asp Ser Ser Lys Lys Arg Gly Pro Lys Pro Arg 190 195 200 aag gag ctc ccg gac ccc tca cag agg ccc tta ggc gaa ccc agc gcc 733 Lys Glu LeuPro Asp Pro Ser Gln Arg Pro Leu Gly Glu Pro Ser Ala 205 210 215 220 ggc ctc gga gag tac ctc aag ggc agg aag ctg gac gac acc cct tcc 781 Gly Leu Gly Glu Tyr Leu Lys Gly Arg Lys Leu Asp Asp Thr Pro Ser 225 230 235 ggg gca gga aag ttt cca gcc ggc cac agt gtg atc cag ctg gcc cga 829 Gly Ala Gly Lys Phe Pro Ala Gly His Ser Val Ile Gln Leu Ala Arg 240 245 250 aga cag gac tcg gac ctg gtg ggt ggt acc agc cct agc tca 877 Arg Gln Asp Ser Asp Leu Val Gln Cys Gly Val Thr Ser Pro Ser Ser 255 260 265 gct gag gcc acg ggc aaa ctg gct gtg gac acc ttc ccg gcc agg gtg 925 Ala Glu Ala Thr Gly Lys Leu Ala Val Asp Thr Phe Pro Ala Arg Val 270 275 280 ata aag cac agg gct gcc ttc ctg gag gcc aaa ggc cag ggt gcc cta 973 Ile Lys His Arg Ala Ala Phe Leu Glu Ala Lys Gly Gln Gly Ala Leu 285 290 295 300 gatcc aat ggc acc cgg gtc cga cat ggc tca ggc ccc ccc agc tct 1021 Asp Pro Asn Gly Thr Arg Val Arg His Gly Ser Gly Pro Pro Ser Ser 305 310 315 gtg ggg ggc ctg tac cgg gac atg ggg gcc cag ggg gga agg ccc tc c 1069 Val Gly Gly Leu Tyr Arg Asp Met Gly Ala Gln Gly Gly Arg Pro Ser 320 325 330 ctc atc gcc agg atc cct gtg gcc aga atc ctg ggg gac ccg gag gaa 1117 Leu Ile Ala Arg Ile Pro Val Ala Arg Ile Leu Gly Asp Pro Glu Glu 335 340 345 gag tcc tgg agc ccc tcc ctg act aac ctg gag aag gtg gtg gtc acg 1165 Glu Ser Trp Ser Pro Ser Leu Thr Asn Leu Glu Lys Val Val Val Thr 350 355 360 gac gtg acc tca aac ttt ttg acc gtc acc att aag gaa agt aac acg 1213 Asp Val Thr Ser Asn Phe Leu Thr Val Thr Ile Lys Glu Ser Asn Thr 365 370 375 380 gac caa ggc ttt ttt aaa gag aaa aga tgaatgctgg gtgggtgtgt 1260 Asp Gln Gly Phe Lys Glu Arg 385 ccaggaggag agcaggggag agagtgagcg tgagcttggc atagtgattt ttatttctgg 1320 gtgggatgtg gccttttggc tggtcccgtc cctgatgtca cccccacccc accagcccct 1380 ttcatccctc cttcctcccc ctcagttttt gttggaaaga ttatctctag agttatattt 1440 tctattagat gtaaatatgt tatttaagaa aaatatctaa atatatatat ttcaactcga 1500 agttgtttta tttaaaggag agagactctc attgtgcttt agttggggca gcccgaatga 1560 gctggggcag gaggggccc c cttgccccag agctctaggg aagttggggc ctgggtacag 1620 gtttctgaga gtgtctggag gggcttggcc tgcccacctc acccctcctc ccttctccca 1680 cagcccaatg ccagactcct ggcaccaagg cccggcccag atttgctctc tcttcccatt 1740 ggccaggcag gccaacaaaa ggttggctcc ccaatcagaa aaaagggggg gtggggtcag 1800 tctgttttcc ttttttctat tttttttttt tttaaggtaa agaagtctat tagggaaaaa 1860 gtattaactt gaataagctt ttcgtgtgtg atgttgaagg ttaaaacgtc cccagcaggc 1920 agggacagga ggtttctccc caggaccaca ccaggaaatg cactttaggg aggggtgtgt 1980 gtgtggtaca cgcagatcgt gtgtatgtca tgtggataaa atctccccgt tccctcgttc 2040 ctttccttac tccgcagaaa gaaaagaaat ccagcgaatc tgtttacatt cccgaaatgc 2100 caggataaat tgggaggatt gcgtgtcagt gctgagagtt cgagacagtt gttttgcaag 2160 aaaagtgttg gggtggactt ttccttttcg cgtcctctag ctttgccagg agaagagacg 2220 gtggccccca cctcccagga agagttggac aagcctccct gcctggggag ggcgggccgc 2280 cagctctgtg gtggacacat ggccagacag gcccaccctg cgggacccac ggagggaggc 2340 gcggcggcgg gcgctgctag gagcagtggc ttcgcaccca gggcctctcc acggccaggc 2400 ttggagtgtg gctgaggacc acg gctcgga gctcggagct ggggctagac tcacccccgc 2460 ggctccggcc gggcacggga aggaggggcg aggcggggtt ttcatccaag aatgcgcatc 2520 ggaacttttg ctttttcctt ttttttcccc cgtccttctt aaaagcaaaa gctataattt 2580 ataggtcttt tcgattcgca gtgttctcta tttgaactcg acattcaaac tccgccaaag 2640 ggggagggag gagcgggagt tgggagtggg gacggccgcg gcggggaagg ccgtgcgagg 2700 cggcggggcc tgggacgccc ctgcccggcg gacttgaccg ctctgcgctc cgaggacgca 2760 gaatgcgcgc ccctcttttg actcaaaagc acaaatcagt cccctccact ccacccccgt 2820 ctcttggagc acggatcccg cagcctccct gccctccccg cccttaaagg gccagcgaag 2880 atctaacttc ccattgcttg ttgagggagg ggcgcggggg ccctgcacgc cagaggaagc 2940 acagactcgg ggggagcgag gcggggagtc gggggtgggg gagcttcgcg tggggtgggg 3000 ggtgctggga gggaacccca gcctcgtcct ccgcactccc ggcttctcag cctctcctcc 3060 agactttctt gcctttaaag agagaaaagg agggaaacgg tgtactacat gattgtgttt 3120 gtttttgaat atcaaattgc gcctataaag agaagcccct ggaatgggga tttttatcta 3180 ctcacatttg taaaactggt attttagact ttgtataaag aagcgccgtt gaccgagtgt 3240 atctatttaa atgtcgatgc tattttcag a tgaaacttca ctgaaggggc atgtctgtta 3300 cctagtggac gggactgggg gatacgcgtc ttcacctggc cgccgccttc ccttctctcc 3360 cgcctgtcct ttactcccac ctccctccct tcctgggggc tgactttgcc ccttcccttg 3420 gaccttcttt ccagccagct ctgtccctgc cgcccctccg tcctgctgtt tgtccgtggc 3480 cgtgtgtgta tgtgtctcct tctctcgctc ttgcgacgct gacctggggg gtgggtgggc 3540 aggggccggg ggccacgtgg ctgggagtct gcaaccgcgc agggtgtgtg cgctgttggg 3600 tttatttaat tctaagattt gtacaaatct ccaatcgatc tccgcctcag ctcaagagtg 3660 aagcttcggt acctatcttc tgcggtcgtg aatgtctgta tccaataccg ctttttacgt 3720 gtttaaatat atactttgta aatag 3745 <210> 142 <211> 6608 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4062) .. (6608) <400> 142 gtcctggatg tgtcggctcg caagctgcga gtgagcgcgg agaagctgca cttcagcgta 60 gacgcggaga gcggggactt acttgtgaag aaccgaatag accgtgagca aatatgcaaa 120 gagagaagaa gatgtgagtt gcaattggaa gctgtggtgg aaaatccttt aaatattttt 180 catgtcattg tggtgattga ggatgttaat gaccacgccc ctcaatttga taaaaaggaa 240 atacatttag aaattttcga atctgcatcc gctggtacac gactatcgct tgaccctgcc 300 acggatcctg atataaacat aaactcaatt aaagattata agataaactc taatccttat 360 ttttcattaa tggttagagt taattccgat ggtggcaaat acccagagtt atctctggag 420 aaactcctag accgggaaga acagagatct catagcttga tattgactgc cttggacgga 480 ggggacccac caagaagtgc caccgctcac atagaaattt ctgtcaagga taccaatgat 540 aaccccccgg ttttcagcag agacgaatat agaattagtc ttagtgaaaa tctgccccct 600 gggtcccctg tgttgcaagt gacagccact gaccaggatg agggggtcaa tgctgagata 660 aactactact tccgaagcac tgcccagagc acaaaacata tgttctcatt ggatgagaaa 720 acaggtatga ttaagaataa ccagtcattt gattttgaag atgtagaaag gtacaccatg 780 gaagtggaag cgaaggacgg aggtggtctc tctacccagt gtaaagtaat catagaaatc 840 cttgatgaaa acgacaacag cccagaaata atcatcactt ctctctctga tcagattttg 900 gagaattcac ctccaggaat ggttgttgcc ctcttcaaaa cacgggatct ggatttcgga 960 ggaaatggag aagtcaggtg taatatagaa acagacattc cattcaagat ttattcttct 1020 tccaataact actacaaact ggtgacagat ggagccctgg accgagagca gacaccagaa 1080 tacaatgtca ccatcgtagc cactgacagg ggcaagccgc ctctttcttc cagtagaagc 1140 atcaccttgt atgtcgctga catcaacgac aacgccccag ttttcgacca gacgtcctac 1200 gtggtccacg tggccgagaa caacccgcca ggagcctcca ttgcgcaagt gagcgcctct 1260 gacccggatt tggggctcaa tggccacatc tcctactcta tagtggcgag tgacctagag 1320 cccctggcgg tgtcgtcata cgtgtcagtg agcgcgcaga gcggggtggt gttcgcgcag 1380 cgcgcctttg atcacgagca gctgcgcgcc ttcgcgctca cgctgcaggc ccgcgaccac 1440 ggctcgccca cgctcagcgc caacgtgagc ctgcgcgtgt tggtgggaga ccgcaatgac 1500 aacgcaccgc gggtgctgta cccagctctg ggtcctgacg gctccgcgtt cttcgatatg 1560 gtacctcgct ctgcagagcc cggctaccta gtgactaagg tggtagcggt ggacgccgac 1620 tcgggacaca acgcctggct gtcctaccac gtgctgcagg ccagtgagcc cggactcttc 1680 agcctggggc tgcgcac tgg ggaggtgcgc acggctcgag ccttaggcga cagggacgca 1740 gcccgccagc gcctgctggt cgctgtgcgt gacggtggac agccgccact ctctgccacc 1800 gccacgcttc atctggtctt cgcagacaac ttgcaagaga tactgccaga cctcagcgac 1860 cgccctgtac tctctgaccc ccaggctgaa ctgcagtttt acctggtggt ggccttggcc 1920 ttaatctcag tgctcttcct cctcgccgtg attctggcca ttgccttgcg cctgcgacgc 1980 tctctcagcc ctgctacttg ggactgcttc catcctggtc tctgtgtcaa gtctggacct 2040 gtagttcccc ccaactacag tgaggggact ttgccttatt cttataatct gtgcattgca 2100 catacgggta caaaagagtt taatttccta aaatgcagtg tgcccctaca ttccaatgaa 2160 gacatggttt gcagtgtttc tcctggagcc ttaattccac ctcatggtgg ggaggatttg 2220 acttcacatc ctgagactct gacttcggtg agtttctctt ttttgtgtgt gatttatcta 2280 atagtctact agtttctcat attttaggca tactacttta ttttcatatc tagaatcata 2340 tgtttaaaat ccatagcttt ttacaatatt ttctcaatgt tttttcaatt atagttttca 2400 ctatgtattt ggttcataag ttgctctatc tttttgtaaa ataatgtcac cagactgaag 2460 atattttgtc tttgtctttt tttttttttt ttttttttga gatggagtct cgcactccag 2520 cctgggcgac agagtgcgac c ctgtctcta aaataaataa ataaatatgc aggcagggcc 2580 aagtgtgctg taatcccagc actttgggag gtggaggtgg agaatctctt gagcgcagga 2640 atttgagacc agcctgggca acacagggag actccatcgc tacagaacat ttaaaaatta 2700 gcagggtgtg gtggcacatg cctgtggtct cagctgctct ggtggctgtg gtgggagaat 2760 cgcttgagcc caggaagtct aggctgcagt gagctgtcta ggtgacagag tgagaccctg 2820 tctcaaaaaa aaaaaagaca tttctaagaa ataaatgaaa tactattgcc tttgcactca 2880 gtctctgtct ctgattctct gatagaagat ttttgaagaa aaaagataaa atctttgaag 2940 agttctatac ttggaaggca tagtgacata aacacttctg aacatcctgt tctctgtgtg 3000 aaagaagtga acttctatac cctttgcatt tgagggaaca attgctactg ggttgatggg 3060 cacacacagt tgaagatatg tgaaccactg gactttggcc tctgatacaa actgcctaag 3120 agaagagatt atttatactg gtattaatgc tctgatgaaa acaggtcatt tgacataaac 3180 acttacttgt taaaaaccta tatcactaca tctaactttg ttttctaaaa cttttagtac 3240 ttcaaattct acgtatttct tttctcatta caatgcaaac agtttaattt gcaactgtaa 3300 tatatgttca ttttagtttg tgattacctg cttaatcatt taaataggtc catttaactt 3360 gtatccctgt aagataaagt atgtttt aca caaaaaggtt aattaaggct cagtaaaact 3420 attctagaag agtactttaa aaacctctta cacaatccta agctaaataa gtttaatgaa 3480 ttaagtagtt acaattataa agcttcagag tgaattatct catgagttta tttaatataa 3540 tctttgtatg aatgtatact aaataaaatt ggcctattca aatcacaatt ttaaattata 3600 agacttttct gaatttacct agacactaat atgacctaaa ataagtatta tttacctttt 3660 attaaagtgt gtacatttct gttgggaaaa cgtgttgcaa atatatattt aaccaaacat 3720 tatcttgaaa tatttacaat attttcactc cactttatca cacctcccct aagaaaccta 3780 catatagtaa attatttaaa gataggagtg gagaaaccaa agaatctatg taaaatataa 3840 taatccaaca gaatagttta ctttccattg catgtatcac ttgggtgcag taacttctta 3900 ggactctgag cgccgctgtt cacctactag gagagaaaac gcagccagag ctcaatccgg 3960 attctcaggg cttcaactac acaagcccca caaaccggct gctgggctgc agggaagctc 4020 actccagaat ttaaagtgcc caggctacag agacaccctg a agc cac aga aag aca 4076 Ser His Arg Lys Thr 1 5 aag gaa ccg gtt gaa aca cac aac gtg tcc agt gag gac ttt gca gaa 4124 Lys Glu Pro Val Glu Thr His Asn Val Ser Ser Glu Asp Phe Ala Glu 10 15 20 ttc tgt aa c cag act aca atg gcc gct caa agg aat cgc tca aag gaa 4172 Phe Cys Asn Gln Thr Thr Met Ala Ala Gln Arg Asn Arg Ser Lys Glu 25 30 35 tca aag gat tgc agc ggg ctg gtc ctg ctc tgc ctt ttc ttc ttc 4220 Ser Lys Asp Cys Ser Gly Leu Val Leu Leu Cys Leu Phe Phe Gly Ile 40 45 50 cca tgg gag gct gga gcc cgg cag atc tcc tac tca att cct gag gaa 4268 Pro Trp Glu Ala Gly Ala Arg Gln Ile Ser Tyr Ser Ile Pro Glu Glu 55 60 65 tta gag aaa ggc tct ttc gtg ggc aac atc tcc aag gac ttg ggt ctg 4316 Leu Glu Lys Gly Ser Phe Val Gly Asn Ile Ser Lys Asp Leu Gly Leu 70 75 80 85 gcg ccc cgg gag ctg gg gag cgc gga gtc cgc ata gtc tcc aga ggt 4364 Ala Pro Arg Glu Leu Ala Glu Arg Gly Val Arg Ile Val Ser Arg Gly 90 95 100 agg acg cag ctt ttc tct ctg aac ccg cgc agc ggc agc ttg Glc Accu 4412 Phe Ser Leu Asn Pro Arg Ser Gly Ser Leu Val Thr 105 110 115 gcg ggc agg ata gac cgg gag gag ctc tgc gct cag agc gcg cgg tgc 4460 Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys Ala Gln Ser Ala Arg Cys 120 125 130 gtg gt g agt ttt aat atc ctt gtg gaa gac agg gtg aaa ctt ttt ggg 4508 Val Val Ser Phe Asn Ile Leu Val Glu Asp Arg Val Lys Leu Phe Gly 135 140 145 ata gaa ata gaa gta act gat atc aat gac aat gct cca aaattc caa 4556 Ile Glu Ile Glu Val Thr Asp Ile Asn Asp Asn Ala Pro Lys Phe Gln 150 155 160 165 gca gaa aat cta gac gta aaa att aat gaa aat gtc gct gcg gga atg 4604 Ala Glu Asn Leu Asp Val Lys Ile Asn Glu Val Ala Ala Gly Met 170 175 180 cgt ttt cct ctc ccg gaa gct att gat ccg gat gtg ggc gtg aac tcc 4652 Arg Phe Pro Leu Pro Glu Ala Ile Asp Pro Asp Val Gly Val Asn Ser 185 190 195 ctg cag agc tat cag agc ccc aat aag cac ttc tcc cta aga gtt 4700 Leu Gln Ser Tyr Gln Leu Ser Pro Asn Lys His Phe Ser Leu Arg Val 200 205 210 cag agc cgt gcc aat ggc gtc aag tac ccg gag ctg gta ctg gag cac 4748 Gln Serg Ala Asn Gly Val Lys Tyr Pro Glu Leu Val Leu Glu His 215 220 225 tcc cta gat cgc gag gaa gag gcc att cac cac ctg gtc ctc acc gcc 4796 Ser Leu Asp Arg Glu Glu Glu Glu Ala Ile His His Leu Val Leu Thr Al a 230 235 240 245 tcc gac ggg ggt gac cct ctc cga tct ggc act gtc ctt gtc agt gtg 4844 Ser Asp Gly Gly Asp Pro Leu Arg Ser Gly Thr Val Val Leu Val Ser Val 250 255 260 act gtc ttc gat gca aat gac aac gcg ccg gtc ttc acc ttg cca gaa 4892 Thr Val Phe Asp Ala Asn Asp Asn Ala Pro Val Phe Thr Leu Pro Glu 265 270 275 tac cga gtg agt gtt cct gag aat ttg cct gtg ggc act cag ctg ctg 4940 Tyr Arg Val Ser Glu Asn Leu Pro Val Gly Thr Gln Leu Leu 280 285 290 aca gtc aca gcc acc gac agg gac gaa ggt gcc aat gga gag gtg aca 4988 Thr Val Thr Thr Ala Thr Asp Arg Asp Glu Gly Ala Asn Gly Glu Val Thr 295 300 305 tat tca ttc cga aaa tta cct gac acg caa ttg ttg aag ttc caa cta 5036 Tyr Ser Phe Arg Lys Leu Pro Asp Thr Gln Leu Leu Lys Phe Gln Leu 310 315 320 325 aac aaa tat act gga gaa ata aaa ata tca gaa aat c tat gaa 5084 Asn Lys Tyr Thr Gly Glu Ile Lys Ile Ser Glu Asn Leu Asp Tyr Glu 330 335 340 gaa acc ggt ttc tat gaa ata gaa ata caa gca gaa gat gga gga gca 5132 Glu Thr Gly Phe Tyr Glu Ile Glu Ile Glu Ala Glu Asp Gly Gly Ala 345 350 355 tat ctt gca act gca aaa gtg ttg att aca gta gaa gat gta aat gac 5180 Tyr Leu Ala Thr Ala Lys Val Leu Ile Thr Val Glu Asp Val Asn Asp 360 365 370 aac agt cca gag ctg acc atc acg tct cta ttt agt cca gtg act gaa 5228 Asn Ser Pro Glu Leu Thr Ile Thr Ser Leu Phe Ser Pro Val Thr Glu 375 380 385 gat tca cct ctg gga aca gtc gta gcc ctt tta aat gtg cat gat tta 5276 Asp Ser Pro Leu Gly Thr Val Val Ala Leu Leu Asn Val His Asp Leu 390 395 400 405 gac tct gag cag aat gga cag gta acc tgt tcc att ttg gcg tat cta 5324 Asp Ser Glu Gln Asn Gly Gln Val Thr Cys Ser Ile Leu Ala Tyr Leu 410 415 420 cca ttt aaa tta gaa aag tcc att gac agt tat tac aga ttg gtg ata 5372 Pro Phe Lys Leu Glu Lys Ser Ile Asp Ser Tyr Tyr Arg Leu Val Ile 425 430 435 435 cac aga gcc ctt gac agg gaa cag gta tct tac aat atc aca gtg 5420 His Arg Ala Leu Asp Arg Glu Gln Val Ser Ser Tyr Asn Ile Thr Val 440 445 450 aca gcc aca gat ggg gga agt cct cct cta tca acg gaa gct cac ttt 5468 Thr Ala Thr Asp Gly Gly Ser Pro Pro Leu Ser Thr Glu Ala His Phe 455 460 465 atg cta caa gtg gca gat atc aat gac aac cca cct acc ttc tct caa 5516 Met Leu Gln Val Ala Asp Ile Asn Asp Asn Pro Pro Thr Phe Ser Gln 470 475 480 480 485 gtc tcc tac ttt acc tat atc cca gag aac aac gcc agg ggt gcc tcc 5564 Val Ser Tyr Phe Thr Tyr Ile Pro Glu Asn Asn Ala Arg Gly Ala Ser 490 495 500 atc ttc tca gtg aca gcg ctg gac ccg gag gag aaa aat gcc cag 5612 Ile Phe Ser Val Thr Ala Leu Asp Pro Asp Ser Lys Glu Asn Ala Gln 505 510 515 att att tac tcc ctg gct gaa gac acc atc cag ggg gta cct ctg tcc 5660 Ile Ile Tyr Ser Leu Ala Glu Asp Thr Ile Gln Gly Val Pro Leu Ser 520 525 530 tca tac ata tcc atc aac tca gac act ggc gtc ctg tat gca ctc aga 5708 Ser Tyr Ile Ser Ile Asn Ser Asp Thr Gly Val Leu Tyr Ala Leu Arg 535 540 545 tcc ttc gac tat gag cag ttt cat gag cta cag atg cag gtg aca gcc 5756 Ser Phe Asp Tyr Glu Gln Phe His Glu Leu Gln Met Gln Val Thr Ala 550 555 560 565 agc gac agc ggg gat cct cca ctc agc agc aac gtg tcg ttg ag 804 Ser Asp Ser Gly Asp Pro Pro Leu Ser Ser Asn Val Ser Leu Ser Leu 570 575 580 ttt gtg ctg gac cag aac gac aat gcg ccc gag atc ctg tac ccc gcc 5852 Phe Val Leu Asp Gln Asn Asp Asn Ala Pro Glu Ile Leu Tyr Pro Ala 585 590 595 ctc ccc aca gac ggt tcc aca ggc gtg gag ctg gcg ccc cgc tcc gca 5900 Leu Pro Thr Asp Gly Ser Thr Gly Val Glu Leu Ala Pro Arg Ser Ala 600 605 610 gag ccc ggc tac ctg gtg acc ggt gtg gcg gtg gac aga gac tcc 5948 Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Arg Asp Ser 615 620 625 ggc cag aac gcc tgg ctg tcc tac cgt ctg ctc aag gcc agc gag ccg 5996 Gly Gln Leu Ser Tyr Arg Leu Leu Lys Ala Ser Glu Pro 630 635 640 645 gga ctc ttc gcg gtg ggg gag cac acg ggc gag gtg cgc acg gcg cga 6044 Gly Leu Phe Ala Val Gly Glu His Thr Gly Glu Val Arg Thr A655 Arg 660 gcc ctg ctg gac aga gac gcg ctc aag caa agc ctc gta gtg gcc gtc 6092 Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln Ser Leu Val Val Ala Val 665 670 675 cag gac cac ggc cag ccc cct ctc tcc c acg ctc acc gtg 6140 Gln Asp His Gly Gln Pro Pro Leu Ser Ala Thr Val Thr Leu Thr Val 680 685 690 gcc gtg gcc gac agc atc ccc caa gtc ctg gcg gac ctc ggc agc ttc 6188 Ala Val Ala Asp Ser Ile Pro Gln Val Leu Ala Asp Leu Gly Ser Phe 695 700 705 gag tct cca gct aac tct gaa acc tca gac ctc act ctg tac ctg gtg 6236 Glu Ser Pro Ala Asn Ser Glu Thr Ser Asp Leu Thr Leu Tyr Leu Val 710 715 720 725 gta gcg gtg gcc gcg gtc tcc tgc gtc ttc ctg gcc ttc gtc atc gtg 6284 Val Ala Val Ala Ala Val Ser Cys Val Phe Leu Ala Phe Val Ile Val 730 735 740 740 ctg ctg gcg cac agg ctg cgg cgc tgg cg cg cg cg cg cg cg cg cg cg cg gc 6332 Leu Leu Ala His Arg Leu Arg Arg Trp His Lys Ser Arg Leu Leu Gln 745 750 755 gct tca gga ggc ggc ttg aca ggt gtg tcc ggc tcg cac ttt gtg ggc 6380 Ala Ser Gly Gly Gly Leu Thr Gly Val Ser Gly Phe Val Gly 760 765 770 gtg gac ggg gtt cgg gct ttc ctg cag acc tat tcc cac gag gtc tct 6428 Val Asp Gly Val Arg Ala Phe Leu Gln Thr Tyr Ser His Glu Val Ser 775 780 785 ctc acc gcg gac tcg cga aag agt cac ctg atc ttc ccc cag ccc aat 6476 Leu Thr Ala Asp Ser Arg Lys Ser His Leu Ile Phe Pro Gln Pro Asn 790 795 800 805 tat gcg gac acg ctc atc agc cag gag agc tgt gag aaa aac gat cct 6524 Tyr Ala Asr Thr Leu Ile Ser Gln Glu Ser Cys Glu Lys Asn Asp Pro 810 815 820 ttg tct ttg tta gat gat tcg aag ttt cct ata gag gat acc cca ttg 6572 Leu Ser Leu Leu Asp Asp Ser Lys Phe Pro Ile Glu Asp Thr Pro Leu 825 830 835 gtt cca gtg agt ttt att ttc att ttt act ttt gtt 6608 Val Pro Val Ser Phe Ile Phe Ile Phe Thr Phe Val 840 845 <210> 143 <211> 6889 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (791) <400> 143 ct caa atc ctg tcc cta cac ccc tcc tct ttc tct tca ttt cgt tcc 47 Gln Ile Leu Ser Leu His Pro Ser Ser Phe Ser Ser Phe Arg Ser 1 5 10 15 ccc tcc tct tgc agc acc tcg gca ggt tca aac tct tct ccg gga gcg 95 Pro Ser Ser Cys Ser Thr Ser Ala Gly Ser Asn Ser Ser Pro Gly Ala 20 25 30 tgg cgg cga tcg cga ggt cac gtg atg agc atc ctg ctg ccc aac atg 143 Trp Arg Arg Ser Arg Gly His Val Met Ser Ile Leu Leu Pro Asn Met 35 40 45 gcg gag ttc gac acc atc tcg gaa ctg gag gag gag gag gaa gaa gaa 191 Ala Glu Phe Asp Thrle Ile Ser Glu Leu Glu Glu Glu Glu Glu Glu Glu 50 55 60 gcg gca acg tcg tcg tcg tcg ccg tcg tcg tcg tcg tcg gta tct ggg 239 Ala Ala Thr Ser Ser Ser Ser Pro Ser Ser Ser Ser Ser Val Ser Gly 65 70 75 ccc gac gat gac gag gag gat gag gag ga gag gag gag gag gag gag 287 Pro Asp Asp Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 80 85 90 95 gag gaa gaa gag gag gag gag gaa gag gag gag gaa gcg ccg ccc ccg 335 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Pro Pro Pro 100 105 110 cct cgg gta gtg agc gag gag cat ctg cgg aga tat gct ccc gac cct 383 Pro Arg Val Val Ser Glu Glu His Leu Arg Arg Tyr Ala Pro Asp Pro 115 120 125 gta tta gtg cgg ggt gcc ggc cac atc act gtg ttt ggc ttg ag aac 431 Val Leu Val Arg Gly Ala Gly His Ile Thr Val Phe Gly Leu Ser Asn 130 135 140 aag ttt gat act gaa ttt ccc tcc gtt cta aca ggg aag gtg gcc cca 479 Lys Phe Asp Thr Glu Phe Pro Ser Val Leu Thr Gly Lys Val Ala Pro 145 150 155 gaa gaa ttt aaa acc agc att ggc cgt gtg aat gca tgt ttg aaa aag 527 Glu Glu Phe Lys Thr Ser Ile Gly Arg Val Asn Ala Cys Leu Lys Lys 160 165 170 175 gct ctc gtg atc aaa tgg ctg ctg tgt ggt tgt ctc tgc tgc 575 Ala Leu Pro Val Asn Val Lys Trp Leu Leu Cys Gly Cys Leu Cys Cys 180 185 190 tgt tgc aca ctg ggt tgc agc cta tgg cct gtt att tgt ctc aac aaa Cyg Leu Gly Cys Ser Leu Trp Pro Val Ile Cys Leu Asn Lys 195 200 205 aga acc aga aga tca att cag aag tta ata gaa tgg gaa aat aac aga 671 Arg Thr Arg Arg Ser Ile Gln Lys Leu Ile Glu Trp Glu Asn Asn Arg 210 215 220 tta tat cac aag ctt gct ttg cac tgg aag ttg act aag agg aaa tgt 719 Leu Tyr His Lys Leu Ala Leu His Trp Lys Leu Thr Lys Arg Lys Cys 225 230 235 gaa act agc aat atg atg gag tat gta ata cta ata gaa ttc tta cca 767 Glu Thr Ser Asn Met Met Glu Tyr Val Ile Leu Ile Glu Phe Leu Pro 240 245 250 255 aaa tat ccc ata ttc cga cct gac tgaggagttt tatccagtca cttctgtgtt 821 Lys Tyr Pro Ile Phe Argaccttgt accttt acctttcc tgaagatggt ctcctttgct 881 gtgttcaact tattctttat aatggtagaa tattcttctc gctcttttgt gttggtttat 941 gaagaaaatt tgcacatctt ttttgtcttt caatgaggct tgtgttttgc actctcaatt 1001 ttaaatacac acacatgcgt gtgtgcatat acatatatag atagttgcca ttaaagataa 1061 atcatcagtg ttggtgttta aaaaacaaaa acttgttctg agcatgctgc cttataattt 1121 tcatactcat tgtttctaaa ctcgcatcat ttttctaggc tacttgatgc tctgtaatcc 1181 cttactggac aaacttaaat aagcttttgg tagcttttag aaatggtttt actctgcttt 1241 taaaggacat gcttttaaag gacatgcaat taatggcact ggttttgtcc tgcactttgc 1301 tttatcactt atgttagtgg ataaa atatt taaactccta aagacttgta aatattgcct 1361 ctttgcataa tgtaaaatgt ggtatgccat ggtttacata atgtaacatt actcttattg 1421 tattgccaac aattttacat agattttaat atgaatgaag tttgcaagca tccctttgaa 1481 tgtagaaact gctaacatgc tgttttatgg caaggccata atgagtatgt taagaatttc 1541 aggtgtaggg caaggttgcc ctttgtaaca agtggactaa aattgaaatt attatctcag 1601 atattctgta ttgcacctga aaccatgacc tttatttttc catttcgttt aataatttcc 1661 attttgttgt ctactccttc ccacaaaaaa actatttgac atctgacaca tttcacagtc 1721 tcactatcct gcatttatta gccttttctt cctttgaaaa tacacacaat tatgactttt 1781 aaggagtatt ttgagatttc agacatcttc agaaggtatc tagaccctct tgaaagccac 1841 taacaccttt ctgcagttct gatattctag tttgagaaag agagagaact atttgagaag 1901 ctgtagctaa agagtatata gcagctgatt cataattgaa aaaaaattct caattctgtt 1961 tttgatgatc ctttataaaa cattaatgag gaaagacaag tgtttagaca aaagtatttt 2021 agtttataaa ttcagcacat atgtaacatt tatttggtcc atatttctct atttttcttc 2081 acaattaaaa tgattgctag caccacacaa ctagaatttg aaaattcagt ataatgaaag 2141 ctttatatca cattaattca actgcaaatg tatgcctgtt tgtaggcatt atttgtaatt 2201 catagtgcta aaaataaaag tgtctagggc tcagtaatat tttgtcatct tactcttact 2261 gcttttagta aaccttttag gcaagattca tctcagtgaa gtgaacaatc atttcttcat 2321 agaaggtcaa gcctttttaa gccactctta aaatttatgc ctaatttgaa atccacagtc 2381 cttgaccagt ttaaaaaaga gaggaaaaag aagacactat tttatatgtg attataattg 2441 tttgcacaaa cacttttcca ccttcctctg tgccccatta cctctgtgcc actcagtcac 2501 cccaaatctc taacctttag taatgtgtat gcctgcaaat attatgtgtt tgcctgctgc 2561 aaaattgaag gtgtattttt atagacaagg tagaagcctc tgaaaatgta taccaaatgt 2621 cttgttttgt agctaaggtc gggaaaaatt gtatctgagg tttatgttcc agctaatgtt 2681 atcaaattta tgcttcaaac tgtgatattt taataccaaa atcgattttc agcataatac 2741 aaaatatctc attttcactg atagaaaatt gcttttaagt gttgatcctt agaaatctta 2801 tttttttcta taaccttaga atttgatcat atgatggtca taggaacttt ttctgccatg 2861 tataaatcac acttggtttt gctcaaagaa cagcatgaag tggtgaattg tttccatgaa 2921 acaattattg agaatgggaa tacagtatat ctggaaatga cacagtataa tacaagttac 2981 agtagcattt gtcacaaaaa ccacttgtca gcatg tgtaa acttaatttt aaagcctatt 3041 ctaatcactc gagtttatta ttttattgtt cgctatgctg gttgactcat cttagtttct 3101 tcaactaccc aaaaaaatac caattttttt cctctcttgt atgactactt tttcaaactg 3161 ttttcctttg cagggggctg attagcaatt gagtattttg taatgtttgg gcggggttgc 3221 tttgttttca gtgaaattgg ttgcagtgaa tgctaaaatg acacagcaca ctggtgatta 3281 attcctcccc catggagcct tttttctgtt atgcttagga tagaacatac ttgtaatttt 3341 ccattaggtt agtaacatac ttttgtgaaa gttgttttta gactgaagaa agtaattttg 3401 aatttctttg ttacataata ttcctttatg aaacttgtga tagtttccag agcaaaacat 3461 gtatttgcca aagtatataa atctcacaag gctttaagat tacaagctaa aattgttttt 3521 taaaattaat gttccaatgt ttctcatttg gcccaagatt ctggcttcat aaatttgtcc 3581 aactggctat ttttaagctt gtcctaaaag ccaataacat gtttattcct aataactaat 3641 atgggcaagt gttatttaca gatttattaa ctccatccca gatatgtctc cactctttgt 3701 tccctcctaa tgctaattta ggaaagagac cactgtagta aaactttaga agaagatgga 3761 gaagtgcctt gtctttttag aacaaagata acacattacg tgtaaggaag cataataaat 3821 gaattggtag atgattagat tagaaatcat ccttttcaac taggtctaag aatactttac 3881 tagtgtatta tcttttattt attatgtaaa gcttctttcc ttccttttcc ccaatcatga 3941 tatattagtg acaaaatatt acagaaccgg actatcagtc acttaaaaaa acagtataat 4001 tctaatgcta gtaaacatgt aatttaattt agttctggaa ggacagttgt ctttgattaa 4061 agccccacca aaacccattt aagtatttaa tgtacatact attcatatta ttatggcctg 4121 taaacactaa tatctgagca atcaaactgt tttatctacc atttttgatg aaatttgaat 4181 aaagtttaaa aacgtgtaag cctttgaaca aatgtatgaa agctttaaaa gatcattagc 4241 acttttattt tgtttacaaa taagctgcca tttaaaaaaa taaaacctca ctacttgaac 4301 ataaagctcc caaacaatat tgtattaaaa tgtactatat tgacctagga ggatatagaa 4361 attatattca cctgattaac tggagcagtt tcacatagta gaaatacttt ttgctaattt 4421 gattataagt gctcaaattt attgaaatta gattctcatg cctataaaag tatactttaa 4481 aaatattttg caacaactgt caaattattt gggttccttt aaatagcaaa caattgagaa 4541 attttccata aaaatgaata ggttttatta atacctgttc atgtagtatg tggactaaaa 4601 caattgatat atatctgtat gtaaaaatga atgatcttat cttgccccaa atttttctta 4661 cctgattctg agccagcctt tttgttttga tggcaccctg tgagt atgtt ccattttctg 4721 tgaactttgt caaattcata ctatatgagg aaatgatcta atattgtggg ctccaggcag 4781 gtcatcttaa ttgcatgtct gtctcttctg taaaatgatg aggtggaacc tagagctgga 4841 caaaaaatta gagatcactt aacattctgt gattcaagga attcttagga catttttact 4901 ctatagaatc tcagaatgat tattctcaga tctactgtcc ttggtggaaa ctctcacagt 4961 gccttgcatg cagtaaaagt ttgatttgcc gactggctga cgtgttaatt atcacacaga 5021 ctccaagaac ctgatgcttg ctagacctta gttccttggt gatgctaaga gtaaatgtag 5081 ttttcctagg aactgagcac tgaggtctgt gtcctttgcc tgtgtagaat ctgtctatgc 5141 agttggtatt caggcaagaa ttttagctgt aacaacaatg gaaatattgg aggacccact 5201 ttggcattta tgtaaagatt tcatatccta tccaacattt actttagtgt ctaatcaaat 5261 tccataccct caaaaagatc tgttggaaca aattgataaa attaggtgga aaggaaagtg 5321 gtatgggact caaatacaag tcacttctgg tttaattatt ggctctgctg cttaattcct 5381 ctgtacctca cgtcctcatt gtcgaagtgg ggacaataat ctggacctac ctcacagggg 5441 aattgaggat attttcatat attagtgtgc tttgaagttg actgaaagat atactggata 5501 tcataattat ataatttcta aatagatttc tttaaatcca tgctatgttt tctttttcag 5561 tcaggtccta cagaatgact attgcacttg gtctattgtt ttaatagtaa attttgttat 5621 taatctccta tgtgttaaac gtgggtaatt gtattatgtt aatacatact tagggaggaa 5681 aagcaggtgg atgtaaatca gtgattccca acttcagcag atgatagcag tggagggtat 5741 ccttgagctt tttgtaatat ttcaaaaagt atattagaaa ttatacattt acccataata 5801 ttcctgcttc acaagtcaat taagacattg aatttccatt cattttgcct atattctctc 5861 aaaagctgtg aatggcagta tgtttttgat taataataaa ataagaaatc ctattatgtg 5921 caacttatta aatacttggg aacatgggaa aagaataatg aagggattct tatggtgaaa 5981 atgttgggaa ccacttttat aaaggaacta agattatttg accccctcca cagattgctt 6041 acctagtctc taaataatga aatgtgtgtg tttgtgtgtt ttggctatat taggctatat 6101 aacttcaggt tagaatttgc cttcagtttt ttttctgttt tagaatatca ctggcctaat 6161 ttatttaggt gtgtacatgt tgctcataca tacacacaca tataggatta caaatgtgga 6221 aaatgttata atgtcatatt ctagcattgg actaaatatc aatttctgac tcttaaagta 6281 gttctgtgta taaattcaac atgatgaatc aaggcaataa tttctcaaat gttcttttat 6341 ttctttgttt ttatctcgac tttttatttt ccattttttc tagtacgcaa atagt gtaaa 6401 attgttttaa tgcctggact ttgaaacaag taacaagtgt ttgaaagtat ataatctacg 6461 agcgaatttg ccctccttgg actaaccaca tacaaatatg aatctggctg caagaacagg 6521 atatccaggt aactagagag tgggcattga taaaaatatc tggtggagaa gcctaggatt 6581 tcaacttttt gtcagaggat tcctgttggg acagctttac cagaaaagaa taatagcgga 6641 tatgttcatc caaactaaga actttcatgc atcttgcatt gttacatagc ctgtggaatg 6701 aattcatttt ttctcccttg agtccaggaa tgacttccct ggaaaaactc aatctatata 6761 cagctgtgcc aaaatgaagg atacctgcct ctccgaaact ttcactgctg cttctgtcat 6821 tgttcacttg tcagataaaa ttttattatc tcaggatgca aatttaaaat aaagtgtaaa 6881 tctatgtt 6889 <210> 144 <211> 3375 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1141) <400> 144 g cgg ccg ctt ccc ggg tac ccc gac gcc gag gcc ccg gag cct tcc tcc 49 Arg Pro Leu Pro Gly Tyr Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser 1 5 10 15 gct ggg gct cag gca gcg gag gag ccg tcg ggg gcc ggc tca gaa gag 97 Ala Gly Ala Gln Ala Ala Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu 20 25 30 ctg atc aag tcg gac cag gtg aac ggc gtg ctg gtg ctg agc ctc Pct ctc Lec ly Gln Val Asn Gly Val Leu Val Leu Ser Leu Leu 35 40 45 gac aaa atc atc ggg gcc gta gac cag atc cag ctg act caa gca cag 193 Asp Lys Ile Ile Ile Gly Ala Val Asp Gln Ile Gln Leu Thr Gln Ala Gln 50 55 60 ctg gag gag cgg cag gcg gag atg gag ggc gca gtg cag agc atc cag 241 Leu Glu Glu Arg Gln Ala Glu Met Glu Gly Ala Val Gln Ser Ile Gln 65 70 75 80 ggc gag ctg agc aag ctg ggc ag gc acg agc aat acg 289 Gly Glu Leu Ser Lys Leu Gly Lys Ala His Ala Thr Thr Ser Asn Thr 85 90 95 gtg agc aag ctg ctg gag aag gtg cgc aag gtc agc gtc aac gtg aag 337 Val Ser Lys Leu Leu Glu Lys Valg Val Ser Val Asn Val Lys 100 105 110 acc gtg cgc ggc agc ctg gag cgc cag gcg ggg cag atc aag aag ctg 385 Thr Val Arg Gly Ser Leu Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu 115 120 125 gag gtc aac gag gcc gag cc aaa gtc atg 433 Glu Val Asn Glu Ala Glu Leu Leu Arg Arg Arg Asn Phe Lys Val Met 130 135 140 atc tac cag gat gaa gtg aag ctg ccg gcc aaa ctg agc atc agc aaa 481 Ile Tyr Gln Asp Pro Glu Val Lys Le Lys Leu Ser Ile Ser Lys 145 150 155 160 tcg ctg aaa gag tcg gag gcg ctg cca gag aag gag ggc gag gag ctg 529 Ser Leu Lys Glu Ser Glu Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu 165 170 175c cgg gag cgg ccc gag gag gac gca gcg gcg ctg gag ctt tcg 577 Gly Glu Gly Glu Arg Pro Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser 180 185 190 tcg gac gag gcg gtg gag gtt gag gag gtt att gag gag tcc cg Asp Glu Ala Val Glu Val Glu Glu Val Ile Glu Glu Ser Arg Ala 195 200 205 gag cgt atc aag cgc agc ggc ctg cgg cgc gtg gac gac ttc aag aag 673 Glu Arg Ile Lys Arg Ser Gly Leu Arg Arg Val Asp Asp Phe Lys 210 215 220 gcc ttc tcc aag gag aag atg gag aag acc aag gtg cgt acc cgc gag 721 Ala Phe Ser Lys Glu Lys Met Glu Lys Thr Lys Val Arg Thr Arg Glu 225 230 235 240 aac ctg gag aag acg cgc ctc aag acc aag gaa aac ctg gag aag acg 769 Asn Leu Glu Lys Thr Arg Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr 245 250 255 cgg cac acc ctg gag aag cgc atg aac aag ctg ggc acg cgc ctg gtg G 817 Arg His Thru Arg Met Asn Lys Leu Gly Thr Arg Leu Val 260 265 270 ccc gcc gag cgg cgc gag aaa ctg aag acg tcg cgg gac aag ttg cgc 865 Pro Ala Glu Arg Arg Glu Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg 275 280 285 tcc ttc acg ccc gac cac gtg gtg tac gcg cgc tcc aag acc gcg 913 Lys Ser Phe Thr Pro Asp His Val Val Tyr Ala Arg Ser Lys Thr Ala 290 295 300 gtc tac aag gtg cca ccc ttc acc ttc cac gtc aag atg gag 961 Val Tyr Lys Val Pro Pro Phe Thr Phe His Val Lys Lys Ile Arg Glu 305 310 315 320 ggc cag gtg gaa gtg ctc aag gcc acc gag atg gtg gag gtg ggc gcc 1009 Gly Gln Val Glu Val Leu Lys Ala Thr Glu Me t Val Glu Val Gly Ala 325 330 335 gac gac gac gag ggc ggc gcg gag cgc ggg gag gcc ggc gac ctg cgg 1057 Asp Asp Asp Glu Gly Gly Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg 340 345 350 cgc gg ccc gac gtg cac gcg ctg ctg gag atc acc gag gag 1105 Arg Gly Ser Ser Pro Asp Val His Ala Leu Leu Glu Ile Thr Glu Glu 355 360 365 tcg gac gcc gtg ctg gtg gac aag agc gac agc gac tgagccgc Acc Asc Vale Ser Asa Val Asp Lys Ser Asp Ser Asp 370 375 380 ccgctgccac ccaccccatt cctcgctcct tccgaacttc ctctttcgca ttctctctcg 1211 gctcgagctg gctgagattt ttctaaattg aaaacacgcc cccctcccca cacctccagg 1271 aactccactc ccagtcttag agctgttagg acccgatggg gaggcagccc ccgcagtgga 1331 cagcccccgc ttggacacag tccgagtgga atgggaaggg aatggtcaat ccctgtcctg 1391 gttgtccaag tcgggatctc agaggaaatt gcagtgattc cacggttagg cccccctggg 1451 ggggctgcct tcccctcagc ctctccccac accacccacc cagctgctgt cattccgctc 1511 actgagctct tcttcattct caccctgatc cctgggggac tcaaagccaa aactgcccaa 1571 agaggaaaga ttgaatccta aaggggatcc ttgcccccat gggaggcccc ctactagaag 1631 gacgtgaaag cagcttttgg gggaaactga ggcagtgggg aagacagagc agaatgagcc 1691 ctcaccctgg ctgggggtcc agcacaggct gtatctgcag agggtcccag aggaacgctg 1751 gagccaagag aagccctggg aaggaggggt ggggaacgac atgcatgtga gggatggcac 1811 actgatgtgt ttatgcacct gtacacagga gcgcatggcc atggctttgg aaaggagaat 1871 ggaaaaatag aagaaggtcg gccgggcttg gtggcttaag cctgtaaccc cagcactttg 1931 ggaggccgag gtgggcggat cacctgaggt caggagttcg ggaccagcct ggcaaacacc 1991 ccatctctac taagcgaaaa cccatctcta ctaaaattac aaaaattagc tgggcatggt 2051 tgcgcatgcc tgtaatccca gctactttgg aggctgaggt ggggagaatt gcttgaacct 2111 gggaggtgga ggttgcagtg agccaaggtc gcgacactgc actccagcct gggtgacaga 2171 gtgagactcc atctcaacag aaggaaaaaa aaggaaaata ggagaaggtg gaaatgggtg 2231 aagagagaag tcccctcact agctgcatga gaaatctatc ttactgtggt tctccatggg 2291 cagcaggacc atttttcaga atcaagaggg aggacagtgt gagaaggcga tgatccaaag 2351 aagacagaga ggtcagcccc acccgatccc tcaaatgggc tcttggaggc acccccaggg 2411 gcagcccatt tctcaaagtc cagaaaatta gggtcccaga agggggcagc agcag gctgg 2471 gagttaggag ggagagcagg gtgccggccc tgccaccaag ttgagagctg gaggggaggt 2531 ggggagagaa catcacagag cagccagccc tggttcactc ctggcagttt cttctcaagc 2591 tccttcccta ggagcatggt ggcacgtgcc tgtggtctca gctacttggg aggctgaggc 2651 gggaggatcg ccagagccca ggagtttgag gctgcagtga gctatgaggg tgcctctgtg 2711 ctccatccta ggcaacagag tgagacgctg tttaaaaagg aaaaaatcct tccctagagc 2771 tagtatccta aagctgcaga gctagcccag acctcattgg tttccttgtc cttggggtgc 2831 ttttcctgaa tctttggggg tgaagggagt gttgctccca gtccagaggc ctgattctgt 2891 tcggactggg ttctcaagac acgaccaggt tctcaagaca cgagtcccct tgttcctccc 2951 cattaaaggg ggtttgtcag aagcaagaac agcccctctc cccagtcaca gcctgaaggg 3011 aggccccgag agcttcctcc ttccccccac ctgctcctta ccttctctgc cctgcttttt 3071 agaactgcag ttcattgttt taagggattg ggggagggag cctggggaca caaacctttt 3131 atacaataca aagctttgct tttttttttt ttttcttcct tttccctttc tcggttctct 3191 tctctcctct gaatggctga agacccctct gccgagggag gttggggatt gtgggacaag 3251 gtcccttggt gctgatggcc tgaaggggcc tgagctgtgg gcagatgcag ttttctgtgg 3311 gcttggggaa cctctcacgt tgctgtgtcc tggtgagcag cccgaccaat aaacctgctt 3371 ttct 3375 <210> 145 <211> 5633 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (880) <400> 145 g cgc ttt ggg aag gag cac gca gtc atc atc ctc aac cac aac ttc gag 49 Arg Phe Gly Lys Glu His Ala Val Ile Ile Leu Asn His Asn Phe Glu 1 5 10 15 atc gac ttc ctc tgt ggg tgg acc atg tgt gag cgc ttc gga gtg ctg 97 Ile Asp Phe Leu Cys Gly Trp Thr Met Cys Glu Arg Phe Gly Val Leu 20 25 30 ggg agc tcc aag gtc ctc gct aag aag gag ctg ctc tac gtg ccc ctc ly Gly Leu Ala Lys Lys Glu Leu Leu Tyr Val Pro Leu 35 40 45 atc ggc tgg acg tgg tac ttt ctg gag att gtg ttc tgc aag cgg aag 193 Ile Gly Trp Thr Trp Tyr Phe Leu Glu Ile Val Phe Cys Lys Arg Lys 50 55 60 tgg gag gag gac cgg gac acc gtg gtc gaa ggg ctg agg cgc ctg tcg 241 Trp Glu Glu Asp Arg Asp Thr Val Val Glu Gly Leu Arg Arg Leu Ser 65 70 75 80 gac tac ccc gag tac atg tgg ttt ctc cg tac ggg acg cgc 289 Asp Tyr Pro Glu Tyr Met Trp Phe Leu Leu Tyr Cys Glu Gly Thr Arg 85 90 95 ttc acg gag acc aag cac cgc gtt agc atg gag gtg gcg gct gct aag 337 Phe Thr Glu Thr Lys His Arg Val Ser Met Glu Val Ala Ala Ala Lys 100 105 110 ggg ctt cct gtc ctc aag tac cac ctg ctg ccg cgg acc aag ggc ttc 385 Gly Leu Pro Val Leu Lys Tyr His Leu Leu Pro Arg Thr Lys Gly Phe 115 120 125 acc acc gca gtc aag tgc ctc cgg ggg aca gtc gca gtc tat gat 433 Thr Thr Ala Val Lys Cys Leu Arg Gly Thr Val Ala Ala Val Tyr Asp 130 135 140 gta acc ctg aac ttc aga gga aac aag aac ccg tcc ctg ctg ggg atc 481 Val Thr Leu Asn Phe Arg Gly Asn Lys Asn Pro Ser Leu Leu Gly Ile 145 150 155 160 ctc tac ggg aag aag tac gag gcg gac atg tgc gtg agg aga ttt cct 529 Leu Tyr Gly Lys Lys Tyr Glu Ala Asp Met Cys Val Arg Arg Phe Pro 165 170 175 ctg ga gac at ccg ctg gat gaa aag gaa gca gct cag tgg ctt cat 577 Leu Glu Asp Ile Pro Leu Asp Glu Lys Glu Ala Ala Gln Trp Leu His 180 185 190 aaa ctg tac cag gag aag gac gcg ctc cag gag ata tat aat cagag Leu Tyr Gln Glu Lys Asp Ala Leu Gln Glu Ile Tyr Asn Gln Lys 195 200 205 ggc atg ttt cca ggg gag cag ttt aag cct gcc cgg agg ccg tgg acc 673 Gly Met Phe Pro Gly Glu Gln Phe Lys Pro Ala Arg Arg Pro TrpThr 210 215 220 ctc ctg aac ttc ctg tcc tgg gcc acc att ctc ctg tct ccc ctc ttc 721 Leu Leu Asn Phe Leu Ser Trp Ala Thr Ile Leu Leu Ser Pro Leu Phe 225 230 235 240 agt ttt gtc ttg ggc gc tc gga tca cct ctc ctg atc ctg 769 Ser Phe Val Leu Gly Val Phe Ala Ser Gly Ser Pro Leu Leu Ile Leu 245 250 255 act ttc ttg ggg ttt gtg gga gca gct tcc ttt gga gtt cgc aga ctg 817 Thr Phe Leu Gly Phe Gly Ala Ala Ser Phe Gly Val Arg Arg Leu 260 265 270 ata gga gta act gag ata gaa aaa ggc tcc agc tac gga aac caa gag 865 Ile Gly Val Thr Glu Ile Glu Lys Gly Ser Ser Tyr Gly Asn Gln Glu 275 280 285 ttt aag aaa aag gaa taattaatgg ctgtgactga acacacgcgg ccctgacggt 920 Phe Lys Lys Lys Glu 290 ggtatccagt taactcaaaa ccaacacaca gagtgcagga aaagacaatt agaaactatt 980 tttcttatta actggtgact aatattaaca aaacttgagc caagagtaaa gaattcagaa 1040 ggcctgtcag gtgaagtctt cagcctccca cagcgcaggg tcccagcatc tccacgcgcg 1100 cccgtgggag gtgggtccgg ccggagaggc ctcccgcgga cgccgtctct ccagaactcc 1160 gcttccaaga gggagccttt ggctgct ttc tctccttaaa cttagatcaa attttttggt 1220 ttttaatcag ttatcttggg aacttaacct ggcccctcac ctcttctgca ccccccgccc 1280 ccgaaactgt ctcgtaatga atttctgctg tcctcctggg agtggacggc cgggtcccgt 1340 cccccgggag catcgctcgg ctcagcacct tggctcccag tgggggcccc gtggagggcg 1400 cccgtagtga taagcacacc ggcacgaacg tcaggtccat tcctcgaagt cggagccctc 1460 actctgccct gtcctggggc tggctgaggg cgaacgcccc acctcacttt ctagagccct 1520 gtctgtccta gctcctatct gaccttgtgt gtaaatacgt acatctgttt ttaaagtgga 1580 tgggcccctg agaactcagt gaaatgcaga gttctccatg cacctaaagc tcctttgtcg 1640 ctctcatggc tgtcagatcc tggtccctcc acactgggtg ctggggaggg aggaccctcg 1700 gggctaccgc gcgccccccc atcccacaga tcaggagcca aggagggaga acagggcagc 1760 ctgtgggact ctaggatgct tcagaagaag cgacggcacc gtcaaccctc tgttttttaa 1820 aggtggttgg agactgttaa cactgagctc attgacttct agagatttta tttttactgg 1880 ttgatctctt ggtggttttc aacttcctgc tggaaactag aggtggggca ccccccaccc 1940 cccagcctcg cactgtgtcc ttggggaagg cccgccccca tcctggccgg tgtcactgtg 2000 gcccggccac ccctgagcgc ccagctccct a cctcctgga cgtctctgag agtccaggca 2060 gagcagaggg cagcgctcgg ccggtcatgc tggctccctt ggccttgcag cgagcccctg 2120 gcccacgccg agcgagggat gcttctccct acagcatgtc cactcccccg gcatggccag 2180 gtggggcccc tggggcaatg gcagtggtag aacgctcaac ttggttgcgg taccatcagc 2240 ccacctgcat ttggctttcg acttgcttgt tctaagtcac agcgccctca tctttttagc 2300 aaggtaaaaa aaccaaaatg ggtgttatct ctgatatctt gaaaccagcg ttctgaatag 2360 aggtaggttg agttttctag gggaaaacaa atggagaaaa gaggcatgaa gaaaagtaaa 2420 ccgagaacat aattaggcat cgggcctaag tgtcctgggg agattggagg ggacggcagc 2480 gttctgcatg atggaggcgc tgccgggccc cgggtctgtg ggggccgtgc tctcagggcg 2540 tgtgcgggac gccacctgtg cacacctgct cagagcacgg ctcctcgcag gggtgaaggg 2600 gcagaccaac gaaaccagat gagaccaacg acaccatgcg agacacgctt gcagacactg 2660 ttgttttgga aatgtgcttc cctccatctg aaatctcatc cctccacccg cccactcggg 2720 cagctgtgcc gtgggcaggg catgcgctcc cctggctgag caccccagag attctcctgc 2780 accttcctca tgccgcacgc tgctcatccg tctccatgtg tgtttagatc catgccattc 2840 actgactcac taacacctgc aaaatcttta aggaaaa aag ctgaagggta cgaccatgca 2900 catatgtgac ctggaaaatg caaatttaga tcttttatga tttaattatt attgtttccc 2960 atagaagttc cctccctttg aaattaatat ataatgtata aattctgcac tgagccatgg 3020 cggagctggg cagcccctag gttagagtgg agacggaggc ccaggcgcag gggtcacacc 3080 tcatctggtt tccttcccat ctcacagctt agcttgtgct tctcaacacc aagtctttaa 3140 gagcaataaa aactacacca tgaatgtttg aatttttttt ttttgggggg gggagggtgg 3200 attttgcttt tcatccagaa ggaaaagggg aggagagctc ctttacattt tttaaattaa 3260 attcataaat cccagaacag tctttttttt ttctttttcc tttacaccct acttctgagc 3320 ttaattcagt tgatgttatg tccaaattca ggctgagtgc tcaggctgaa gcaactctgt 3380 agcccacagt ccgtgctggc cactgtcggg gtgaggcaca ttctaggcct ggcatcgctg 3440 atgccctctg cacccagtcc ttgagccagg ccgaggacag gaagggcatt gctggcctgt 3500 agctcctgtt acccacccag agccaggcgc cacactggag gctcccaggc gggagggccc 3560 aggcccaccc acgggcgtct ggccggtcaa gctcccagcc tgggccgtgg tctcctgggg 3620 acgccgctgg cctcccagct taggcccagg tgccaggtgt catggggtct cctgcccatc 3680 ttcccaagga tgccattgct gtcttcatcg tcttcccccg t gtgagacac tggttgtctg 3740 gtactcggcg acagtgtacc agacgcgcac cctatgtgag gtgctttaag gtccctgtcc 3800 tcaggaagcg cagtctggtg gaagagatga gcgctgaaca aatcactaaa taacacaaaa 3860 caacaatgta agcagcactt tcttgtgtaa aaaaaaaaaa aaaagcacgt cctgtcgatg 3920 aattttgagt ctctctgcct tgcctgtccc gactcccttt cgcgcaccgt ggcatgagaa 3980 tctttcctca cgctgttcgt tgcggtattg ctgagcattg atgttgattt gaaggaaaag 4040 ccgtggttgg acccagctgt gtgtttcact cacgtgcaat tgagtagctg ttgccaggct 4100 gtccatgcct gttgtgacta ccggttgggg tcagatttgg ggtgaagaat gagtaagttt 4160 ctgcatgctt tgtctctacc tgagacactt ctacaacaag ccaagtataa tctctccagc 4220 cctgcagatt ttcacctgac ttgttcagcc ccatgcgtag actcccgctg caggcctctg 4280 gcctgtggct cactgcatgc agcccctggc gtgcaatact agtgctccac ggcgcgatgt 4340 gcttctagcc cttgcactgc acctaggctc agggttcaaa cggccagccc gaaaagcctg 4400 cctgccttct ttctggaaac agcacgtccc cggccgtgtg cctgcccctt tctctactga 4460 gctagtcccc aaaccaaagg caagccccct cgggcctcgg gggatggggc cggccacacc 4520 cctgactccg ccctggctct gccccatacc cctgccgtgg ggccgac ctg ggggatgcag 4580 acatccggct ccgtattcct gcctatcggg gccaggatgc aaaaacaatt tttgcgtaaa 4640 agatgtcaca ctgatctgct ggagtggggt ggacacatga attcagtttt atcatgaaca 4700 ctcgccactg gctgcttgtt aattcaggga taatggtggc attcttacaa actgctcggg 4760 aaatagaatg acgggaacac ttttagggag cccaggaagt taccagggac attggtgtcg 4820 ccggcccagg caacagcagc gtacgctttt caaagatcat tgagttgtct tagaatttga 4880 agctgtgtaa tgacaatgtc acctggagtt cgtctccatt tcttaacttt ttgttgcaca 4940 agtatttgga cagaagtcga actgtgaatg agatactgaa atgcactaaa ttgtattaca 5000 ttaaactgga gttacttgat acaatgaaga aatgcatctg atctacttgt atttattgtc 5060 tcagaattgt acgttgtgac aatcaaatgt tacttgccta aatgccagga aattcaactg 5120 gccttttaat cagcaagatc gccagcaagt actgtaactg taaaggaaaa tctctctctc 5180 tggagaaccc acacaaacca ttgacctgag tgcgcatgac agccactggc ttctttttct 5240 atgattgaaa atctgccatc gctgactgtt ggccagtttc aaagggaccc attgtataca 5300 gggtgcaaat gtattatacg gatgtttcct tttgtacact tcatttttac aagttttgct 5360 actcacaagc tttatgtagt ggaggataga ggtatttttg gtctttagaa g cttgtcggg 5420 gtgagggctg ctaacttaca cttcagaggc ctgtgtccca aaggcctggc tgcgtttgcc 5480 gtgctgtgcg aggacctgtg tacacaggca ggtgtgcgcc tgcccgagcg tgcccgagcag gagtag gagtag ctggtagcat gctgag tgcgag tgcgag tgcgagtg gg <210> 146 <211> 5337 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4113) .. (4778) <400> 146 aatttggcca ggctgagaag actgagcttg atgcccactt tgaaaacctt ctggcccggg 60 cagacagcac caagaactgg acagagaaga tcttgaggca gacagaggtg ctgctgcagc 120 ccaaccccag tgcccgagtg gaggagttcc tgtatgagaa gctggacagg aaggtcccct 180 caagggtcac caacggggag ctgctggctc agtacatggc agacgcggcc agtgagctgg 240 ggccgaccac cccctatggg aagacactga tcaaggtggc agaagctgaa aagcaactgg 300 gagccgcgga gagggatttt atccacacgg cctccatcag cttcctcaca cccttgcgca 360 acttcctgga gggggactgg aagaccatct cgaaggagag gcggctcctc caaaaccggc 420 gtctggactt ggatgcctgc aaagcgaggc tgaagaaggc caaggctgca gaagccaaag 480 ccacggtagg tgtccccgct ccccgctggc ctcctggccc aggctctggc tggagccaag 540 gggtggtggc atgaggggac ctggtatttg gcatgacctc tctcccctct ccctggctgg 600 agatgcctgg ctgggggctg ctgggctgag cctctctgtc cctgccctca agggagcctt 660 ggtggccccc gagctctggt tcccagggag atatctacgg tgtgggcgga ccagcagtgc 720 ccccagctgg gtgcaccacc ccgccaggca gctggagtct cctgcatgcc ctgccctgcc 780 ctcctagatg ctcggctctg tccccggctc tgcccgggca tggcaccttc ttactaactc 840 tactacttgc tgcttgaacg tcaggccgag ggtccctgtg ctcaggcgcc cccacgatgg 900 tgtggaaaac ctgggagctg gaccgcccgc ttgctcaggg ccgtgtccga ggggtcccat 960 gagattggat agggcctggg ccatctggcg tccccttcac tcccagctca ctgaggcctg 1020 ttcagcctgg ctgggtcaat gggacgcagc ctgggacagt gtgcccaggg cgaggccagg 1080 attggaggag ctgggcccaa gggtgaacac cctcctggca caagaggttg ctcggggctg 1140 ccaggcctaa aggctgcctc ataccttgca gagggaactc ccaggcccag gcctactagg 1200 gagatggcta cctgtggctg ccagctgatt agccgaggga ggccaggcct agcctgggct 1260 cacagctgcc catgcacctt gcgttcccct cccatagtgt ggccccagag ccagcactgc 1320 ccctggcgag aaccgtctca ggtcactcaa gtgtgtgggg tctagatcag aggcaggggt 1380 gtagttgttt caatcttggg gttggctagg gtgacctgtg cctattggga tgacctcttc 1440 taaggcacct gaacaggaca gtctcccccg tcacttcggg ccagacaccg tctctggagt 1500 aactcagcca gaacacactc tctccatcag ccaggccaga ggagcctttc ctgtcattgc 1560 agtggtgtgg cctctccctc acctggtggg cctggacaac ctcacatcct ggggttgggc 1620 caggccacct ttccagagct aggacttggg cagccccagg aacagcattc cagaggactc 1680 aagctccaca gctctg tccc cataagcacg cacacgttag gactcttcag gagggcaggc 1740 tgtggtgcct ccctccgccc gaccgcctgg tgtcccctcc cactggggcc tggggggcct 1800 gctcctgcct gcgctgtgga ctcactaact ctttgttttt gttcctttcc gtcctgcttt 1860 gggtaacttg gctcagtgtg agggagatgt gagtatacct gtcccacgcg ctgtgctgct 1920 tccggtctgc ccatcttgcc cgtggaccca cggtgccatg gccagcccac gtccttgggg 1980 cattttgcaa gcagctggtc tccccgccag agcctctact gtgcagggcc tctggtttag 2040 ggggggatgc caggcgttgg ggcctgtgag tcagcttttt gcaaatgttg gacgcctgtc 2100 actctgtctg cccatgcatc catctgtcca ccttcattgt cgggaggggc ctggcccttg 2160 atgcaggagc aagagatgtg gtgtgcggat tctgggatgg aaaaagccat cccagttggg 2220 ggtgggctgt gtttgcggga ccctggggca tctgagtgcc actggtctgg ggaggagggg 2280 gctgtggccc ctggcagggg agagcccagc ctgtgacttg ctcaggcagc ctcggccatc 2340 tcctcaccgc atttgctctc ctgagctcca gtgcctgcag ccacttgatc tttgtctgga 2400 ctctccaagt ccctaggccc ctcatctcca ggtggttgga gtcgggagaa gggggtttgt 2460 gttgtgtttg tatccccgtc cctggggtca ggcctcttgg catctccttg tgcaagactc 2520 tggggtagcc tcctgacctc g accctggcc ctggcccagg gtgaccccct ccccacatga 2580 actctgttcc ccgccagacg gtgcctgact ttcaggagac tagacctcgt aattacattc 2640 tctcggccag cgcctccgcg gtaagcgcac cccaccccca ccccacccct cgtcctcctc 2700 tctccccacg tcccacacca ctgcctctga ctgcacagga gctagaagcc agcttgggta 2760 aggcgggggc actgccatgt gatcaggtca gtcctgagac actggggagg ggcagcagcc 2820 cccacctctg tccacggcct ggccccggtg ccctgtggcc atggagctgg acttgtttcc 2880 ctctgcaaaa cgctggagct ggcggcaggg ccagccacac tgagtagtgt ggagaactca 2940 gggcggcagc tgtcccatcc ccagggcccc tccacctcct gctgtctctg aatgccaggc 3000 cctggggagg ccctgaggat agaggaggag gcctggccgt gcctttctgg agttcacaga 3060 cccctaaaga caggaggcag ggatggcgtc gtaggcctgg agagcgcctg gggggcggga 3120 gggcctgagg ctgtgcttaa ggcccagagg tcctggagca gggcatgtct tgtcctgagg 3180 cttaggcagg gcccccaggg gagttggggc aggaggtggg gaggacagga tcgtggaggc 3240 ttcgcatgtc atggtgtctg ttggttttta ggctttcttg ggaagtctgg tgtttcctat 3300 gtagtttggg gactaggcca cacctctccc tcatgcttgt caccactgct acaccttgtc 3360 tgcccacttt ctctccttcc cgcccc tgga ggtgagaccc tcacctctct cgtgagcatg 3420 ctgcctcatg tcttccgtgc cgtcgttctg tggctgggtg actgtccctc aggccgccaa 3480 ccctagttgg ctctcacagc aacttccagt gctcctggac ggggacttcc taagcagcat 3540 gggggccaca cgggccggcc acgcacactg gcctgggtcc gcattcccta tttcaggctg 3600 ttgtctcggg tcagatctcc ggaagcggca ggagcgctgg gtctcctggt cgtggccggg 3660 cagcgtcttt cttcttcagg gtctggatgc cacttcccgc ctcctccctg tgcccagtgg 3720 aaggagaaac atcctagagg gtggagactg ccctgttttt cttttgccat tgagtcccag 3780 tgtgactcaa gcacgaggcc acctttctct gccagaggac agaaagcttc agtgactggc 3840 ccagggtcac acagttctgc cgcccagccc agcagcctga gccagcagtc aggatggggt 3900 ggggacactc cgtctctctt gagaccccac tcagagaatg gggctgacac tgtaggagaa 3960 atataagcag gactcctgct ggctgctccc ctcctgcatg aggcatgtta gagggactgg 4020 gaccgccagc ccccagctcc catgccgggc ctcggcccag tctcagctcc tgtttgggag 4080 ggggggcaga ggggcagggg ggcagaagtt ga gtc tgg gag ctg ggg cag ggc 4133 Val Trp Glu Leu Gly Gln Gly 1 5 aca ggc tct agg gtc cag ctg tcc tcc tct ccc ctc ccc tgc tgg cca 4181 Thr Gl y Ser Arg Val Gln Leu Ser Ser Ser Pro Leu Pro Cys Trp Pro 10 15 20 ctc ctg ctg ccg tct cca cag ctc tgg aat gat gaa gtg gac aag gcc 4229 Leu Leu Leu Pro Ser Pro Gln Leu Trp Asn Asp Glu Val Asp Lys Ala 25 30 35 gag cag gag ctc cgc gtg gcc cag aca gag ttt gac cgg caa gca gaa 4277 Glu Gln Glu Leu Arg Val Ala Gln Thr Glu Phe Asp Arg Gln Ala Glu 40 45 50 55 gtg acc cgt ctc ttg ctg gag gat at agt agc act cac gtg aac cac 4325 Val Thr Arg Leu Leu Leu Glu Gly Ile Ser Ser Thr His Val Asn His 60 65 70 ctg cgc tgc ctc cac gag ttc gtc aag tct cag aca acc tac tac gca 4373 Leu Arg Cys Leu His Glu Phe Val Lys Ser Gln Thr Thr Tyr Tyr Ala 75 80 85 cag tgc tac cgc cac atg ctg gac ttg cag aag cag ctg ggc agc tcc 4421 Gln Cys Tyr Arg His Met Leu Asp Leu Gln Lys Gln Leu Gly Ser Ser 90 95 100 cag ggt gcc ata ttt ccc ggc acc ttc gtg ggc acc aca gag ccc gcc 4469 Gln Gly Ala Ile Phe Pro Gly Thr Phe Val Gly Thr Thr Glu Pro Ala 105 110 115 tcc cca ccc ctg agc agc acc tca ccc acc act gct gcg gcc act atg 4517 Ser Pro Pro Leu Ser Ser Thr Ser Pro Thr Thr Ala Ala Ala Thr Met 120 125 130 135 cct gtg gtg ccc tct gtg gcc agc ctg gcc cct cca ggg gag gcc tcg 4565 Pro Val Val Pro Ser Val Ala Ser Leu Ala Pro Pro Gly Glu Ala Ser 140 145 150 ctc tgc ctg gaa gag gtg gcc ccc cct gcc agt ggg acc cgc aaa gct 4613 Leu Cys Leu Glu Glu Val Ala Pro Pro Ala Ser Gly Thr Arg Lys Ala 155 160 165 cgg gtg ctc tat gac tac gag gca gcc gac agc agt gag ctg gcc ctg 4661 Arg Val Leu Tyr Asp Tyr Glu Ala Ala Asp Ser Ser Glu Leu Ala Leu 170 175 180 ctg gct gat gag ctc atc act gtc tac agc ctg cct ggc atg gac cct 4709 Leu Ala Asp Thr Val Tyr Ser Leu Pro Gly Met Asp Pro 185 190 195 gac tgg ctc att ggc gag aga ggc aac aag aag ggc aag gtc cct gtc 4757 Asp Trp Leu Ile Gly Glu Arg Gly Asn Lys Lys Gly Lys Val Pro Val 200 205 210 215 acc tac ttg gaa ctg ctc agc taggcaggtg cccccatccc ccccgcattc 4808 Thr Tyr Leu Glu Leu Leu Ser 220 tggcctaggc aggagaggat gggcgcagcc ctgccactta acttgtttgt tggtgacaca 4868 gttgttcaga gg ccccat tctgtccctg cccctagtca cctagctgtg 4928 agggtgcctg aggctgaatg gctccacccc tcccccagcc ctgcttctga cctgtggctc 4988 tggagcccct gcccctgcct gcatccccga gcaccccacc ctccaggctc cactaaggag 5048 ggaggggctg tctgcagcag ctgcactcag cacctaggcc agggtggggc cgccgcagat 5108 gggctcagga agccccaggt gcactcagcg agagccctgc ctttcagttg ccaaaagctg 5168 catcagggga atgcggcaag gcacacaggg ctctggcagc ccctggggac tgggcgctgc 5228 ccctgggagg ggagagcctg gccagggctg gtgttgggcc cggagcagca tcttccggtg 5288 ctatcctccc ctcccacccc tcacagctca agccaagtcc agcggccgc 5337 <210> 147 <211> 5486 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1081) <400> 147 a gct gtg tgt gtc att gac atg tcc tct ttc aca aag ttt gag ata aca 49 Ala Val Cys Val Ile Asp Met Ser Ser Phe Thr Lys Phe Glu Ile Thr 1 5 10 15 tcc act ggg gat cag gca tta gaa gtt cta cag tac ctc ttc tcc aat 97 Ser Thr Gly Asp Gln Ala Leu Glu Val Leu Gln Tyr Leu Phe Ser Asn 20 25 30 gac ctg gat gtg cct gtg ggc cac att gtg cat act ggc atg ctc aac 145 Asp Leu Asp Pro Val Gly His Ile Val His Thr Gly Met Leu Asn 35 40 45 gag ggt gga ggg tat gaa aat gac tgc agc ata gca cga ctg aac aag 193 Glu Gly Gly Gly Gly Tyr Glu Asn Asp Cys Ser Ile Ala Arg Leu Asn Lys 50 55 60 cgc agt ttc ttc atg atc tct cca acc gac cag cag gtc cac tgt tgg 241 Arg Ser Phe Phe Met Ile Ser Pro Thr Asp Gln Gln Val His Cys Trp 65 70 75 80 gcc tgg ctt aag aaa cac atg ccg aaa gac agc aac ctg ctc ctg gag 289 Ala Trp Leu Lys Lys His Met Pro Lys Asp Ser Asn Leu Leu Leu Glu 85 90 95 gac gtc acc tgg aag tac aca gcc ctc aat ctg att ggc cct cga gct 337 Asp Val Thr Trp Lys Tyr Thr Ala Leu Asn Leu Ile Gly Pro Arg Ala 100 105 110 gtg gat gtg ctg tct gag ttg tcc tat gcc cct atg act cca gac cac 385 Val Asp Val Leu Ser Glu Leu Ser Tyr Ala Pro Met Thr Pro Asp His 115 120 125 ttc cca agc ctc ttt tgc aag gag atg agt gtg ggc tat gca aat ggg 433 Phe Pro Ser Leu Phe Cys Lys Glu Met Ser Val Gly Tyr Ala Asn Gly 130 135 140 atc cgg gtg atg agc atg acg cac aca gga gag cca gga ttc atg ctc 481 Ile Arg Val Met Ser Met Thr His Thr Gly Glu Pro Gly Phe Met Leu 145 150 155 160 tac atc ccc ata gag tac gcc ctg cat gta tac aat gaa gtg atg agt 529 Tyr Ile Pro Ile Glu Tyr Ala Leu His Val Tyr Asn Glu Val Met Ser 165 170 175 gtt ggc cag aaa tac gga atc cgg aat gct ggg tat tac gct ctt cgc 577 Val Gly Gln Lys Tyr Gly Ile Arg Asn Ala Gly Tyr Tyr Ala Leu Arg 180 185 190 agt ctc cga att gag aag ttt ttt gcc ttc tgg ggt cag gat ata aat 625 Leu Arg Ile Glu Lys Phe Phe Ala Phe Trp Gly Gln Asp Ile Asn 195 200 205 aac ctc acc acg ccc ctg gaa tgt gga cga gag tct cgg gtg aaa tta 673 Asn Leu Thr Thr Pro Leu Glu Cys Gly Arg Glu Ser Arg Val Lys Leu 210 215 220 gag aag ggc atg gat ttc att ggt cgc gac gcc ctc ctg cag cag aag 721 Glu Lys Gly Met Asp Phe Ile Gly Arg Asp Ala Leu Leu Gln Gln Lys 225 230 235 240 cag aat gga gtc tat cac g atg ttc atc ctg gac gac cat 769 Gln Asn Gly Val Tyr Lys Arg Leu Thr Met Phe Ile Leu Asp Asp His 245 250 255 gat tca gac cta gac ctt tgg cct tgg tgg gga gag ccc att tac cgg 817 Asp Ser Asp Leu Asp Leu Trp Pro Trp Trp Gly Glu Pro Ile Tyr Arg 260 265 270 aat ggg cag tat gtt ggc aag acc acc agc agt gcc tac agc tac agc 865 Asn Gly Gln Tyr Val Gly Lys Thr Thr Ser Ser Ala Tyr Ser Tyr Ser 275 280 280 285 ctg gag cgc cac gtt tgc ctg ggc ttt gtg cac aat ttt tct gag gac 913 Leu Glu Arg His Val Cys Leu Gly Phe Val His Asn Phe Ser Glu Asp 290 295 300 acg ggg gaa gag caa gtg gtg aca gca gat ttc atc gag 961 Thr Gly Glu Glu Gln Val Val Thr Ala Asp Phe Ile Asn Arg Gly Glu 305 310 315 320 tat gag att gac atc gcg gga tac cgc ttc cag gcc aag gcc aag ctc 1009 Tyr Glu Ile Asp Ile Ala Gly Tyr Arg Phe n Ala Lys Ala Lys Leu 325 330 335 tac cct gtc gcc tcc ctc ttc acc cag aag cgc cga aag gat gac atg 1057 Tyr Pro Val Ala Ser Leu Phe Thr Gln Lys Arg Arg Lys Asp Asp Met 340 345 345 350 gag ctg agt gactta cat ggg aag tgatgccacc agggcagcct cacctcctcc 1111 Glu Leu Ser Asp Leu His Gly Lys 355 360 ccatcatctt gtcctagagt gggcgtcacc ttggagcttc tcttccttcc gcctctgttc 1171 ctcttctgga gcctttgcct cccatctctt atctccttga tataattttg aacttgacct 1231 actttaaact tttttgctct gcagccttcc ttgcccttcc acctcctcct cctaatattc 1291 actctgggct cttcttccct tcccacccct cactcagctt ctcgtggtgg caggaggtat 1351 gtctgacagg acagaagcaa gctccactgt ggacatgagt gatggtgaca gctgctttca 1411 aattctgcat ctcaaggcag ggcaagccgg ggtggtgcag gtctcagggc acgagtccct 1471 ctcccttggg ttccattttc ttggagcagc ctattagttc tggtggggtt gccgtgtgtc 1531 ggatgcagcc ctgaggggca gctcgtgcct gcagcccggc agctcgttct cctgttctgc 1591 tgtgctgtgg gctggcactc gatacctctg gcaagaggat gattatctac ctcactgata 1651 agaggcatcg catggacgtt ctctggtctg tagtggagac aagcagttaa cctagcacca 1711 t cctcatcct ccctgcagaa gccattagca gacctttggg ccagggcagc ctccctataa 1771 ttttcttcat ctcttgctaa tctctataat aaggttgctt tttctttctt agttgagtaa 1831 acaagtaagc cacagtgttt gaaagggaaa aaccatattg ccttgtgtgt tgcttttccc 1891 agtcaaaagg gtctgacctt agaaagtccc caccagtgat gctgagtgtt ctgctatgga 1951 aacaatgctg cttttctctc agctgtccaa agttcagccg ttcctccttc cccttctccc 2011 agtgcgtttg actttgtcag gtcagcctca cttgtccctt tcacagttgg cccataaagt 2071 catgtttctc tccctttaga atagggaggg gaagggatca ggtgtgttgt cctgggcctt 2131 tcaaccttgc gggctgtgct gagttccaga gagctgccgg aattccaggt ttgactctcc 2191 agcacagagc agagctacac agaggtgacc cacgttagtc cactgagagt tctgagtcca 2251 aagggtgtac gttgcataag gctagagacc gcttttcctc ctttcccccc aggctctttg 2311 tttccctcca cccacccttc catatcctct ggagcaggag acaatgtggg tgcccagaag 2371 tgccctgcgc tttcaggcag tgtctctgtt ttcccaaggt gaaacttaga tatcatggac 2431 tgttgtccag cctcaatgct tcattttccc cttgcatatc aactgcccta atctgacttt 2491 ttttaagtgc aaataaactg ctataagaca ttttggttag taaaactcta gcctttggcg 2551 tgttgg tatc ttggaagcat tagctctgat aggtctataa gtgtattaag ggacatcctt 2611 ccatttcatt agagcagctt aaaatgctca ggtgtctgcc ttctctggtg tttctttggg 2671 atctctgttt acccacttac gctggctcct tctagacatt tcttgccact tccccaacta 2731 gaccactcct agtgattact gactttagtg cctaaacctt tttggaaggt tctggttggc 2791 ttgttagagg agcatatgat tagaattctg tttgggggtc tagttgtctt ggagcaagta 2851 tgtacttaac tagccgagag atgctgcctc taggcagaga ggaggagagg tgttgccggc 2911 tggagggcca accagtgaac accagctgtg aaggccttgg gagaggagga acaggccctt 2971 gggcagatgc aggcattacc agcagggagc agacttacct ccgaagatgg agacaggtga 3031 ctgagagctg caggcctcct ctgctcttcc aaacacgtag catttgcacc cctccaaagc 3091 catctttgta aaggaaaacg tatttgtaat tgaatccaga agaatttagt tacacataga 3151 cataactctt caaccttaac tatggcaata catttgtgct ttaactgtta catagcagta 3211 tcaccactta ccaggatcca aatcgaaata ataaaagctg tctccatagt ttaaaatcga 3271 atagtgccat catcacagta tattagtcaa atagaagctt catcagaaat gtatcccaca 3331 tagagtttta agacttggat tctcttctgc ccttgttaat ctccaactaa ttactacaga 3391 ttgacacgtt t ttaattagc tgtcctttgt aagaagtcag gaaatctgat gctgtgtcca 3451 aaattatgca ctgtttgttg aagtagaacc agaaatcctg acctcctgtt aaatgacatc 3511 agtttccccc tctgagcaac agactgcttg tcttgctagg agaggaggat ggggggctga 3571 gcactcaggc tgtccattga aaccccttgt ccatgaatag ggtcatactc ctaagactga 3631 tggggtgttg atcttctagg acatcacttg tttattcagt gccccaaaca cagatttctc 3691 ttctagcact ttagagttga tccttgaagt ctctcctggt tcattcaaat acaagctgtg 3751 tgagtctggt ggttttctgt gattggtcta atgtgagctc tttgaacaga cagatctgac 3811 agtgaatgac tctcccctgc ttctggcata actgctttgc ctctgtctag tgtccaagca 3871 tcttagctgt tcaagaggag agggcagcat aacttcctga ccaccggtgt cagatatcag 3931 agcattctgg actcctgaga ggcagtggcc tcttgagtga acaggggagg ccagtagatg 3991 ccccagatcc agagccgtgg ctgcaaatcc agcaggaata aggagggaca accacagcct 4051 cctcatccat gtgtcatttc caagggtttg ccttgtgtct cagctcattc tgggcagcac 4111 gtttgtcttc tgtccctaga gatttgaagg attttggact cttgtgaatg ggtgactgga 4171 cttggcttta cagagttggg tgcttttttc tctctgcaat tacctgtcat agcattttgt 4231 gctcaccacg aaggat ggtc tctgccttct cttgtcggtg tatgccatct gaacctagga 4291 acacaaagta tattggcctc aaacggagac ccagggttgc cagttttccg tgggccttcc 4351 cctcccttga aatgtcttta attacctccc cttcatcgtc aggccacgtg tgacttctgt 4411 tcttagcact gccagggtca ttgacttcca tctaagcttg catcaggaag atgttccttc 4471 tgtgatcatt ggtactgaag ccagaaaagc tctcattcag gaactctgaa gagcaaaaag 4531 ggacaaacac taactgctga gctgggccat ttgatctcct ttcaccttgc attgctgtca 4591 cagcaccttg tatgatggca ggacaggctc cagcagagag aactgcacag tgaccactgt 4651 atttttcacg ctcttccagg gatccctgtc ccccgacatt gaagagatct cattcaggcc 4711 agagacacag agaccacata gcccagtgat taaaccccgg tttcactctg gccccaggag 4771 tggagcctgg ccactcctgt ttggttctca ctgggaggcc cactggcctt ggatcatctc 4831 ctcatgcaca cccggagttt tacctgcttg cttgctttcc tggactgctg tttgcaagaa 4891 agtaactaaa acatgaaaag taaacctcca gcttccacag tatattacct gccgttgcat 4951 gcatttgaaa gttagcctcc tcccttgcca ccgtcttggt ggcagtagcg atgcaagaat 5011 gatgggagct ttccgagagc gttcagtgtt tcactgaaga caggacccat agccttcatt 5071 tctggctctg tgtctcctct g gcatatgga cacatttcct ggcatttgcc tgagtctaca 5131 ccactttttg agaacctgaa atagaaggga atcttctgtg gcccacagtc tccatattgg 5191 cactagaaga ctggcctggc ggaggaattt gcgttggctt gctttcaggg gttagctaca 5251 agattcagct ttatatctct gttgcttctt ggccagtgta gtcaataagg gtcttcttta 5311 acatctaaga tagaggtttg gttggccggg cgtggtcgct tactcctgta atcccagcac 5371 tttgggaggc ccagtgaggt gggagaattg cttgaaccca ggaggcagag gttgcagtga 5431 gctgagattg caccactgca ctccagcctg ggtaacagag tgagactctt gtctc 5486 <210> 148 <211> 4649 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1963) <400> 148 t cga gat act cct gac agt ttt gtt ccc tca tcc tct cct gag agt gtg 49 Arg Asp Thr Pro Asp Ser Phe Val Pro Ser Ser Ser Pro Glu Ser Val 1 5 10 15 gtt ggg gta gaa gtg agc agg tat cca gat ctg tca ttg gtc aag gag 97 Val Gly Val Glu Val Ser Arg Tyr Pro Asp Leu Ser Leu Val Lys Glu 20 25 30 gag cct cca gaa ccg gtg ccg tcc ccc atc att cca att ctt cct agc 145 Glu Pro Pro Glu Pro Val Pro Ser Pro Ile Ile Pro Ile Leu Pro Ser 35 40 45 act gct ggg aaa agt tca gaa tca aga agg aat gac atc aaa act gag 193 Thr Ala Gly Lys Ser Ser Glu Ser Arg Arg Asn Asp Ile Lys Thr Glu 50 55 60 cca ggc act tta tat ttt gcg tca cct ttt ggt cct tcc cca aat ggt 241 Pro Gly Thr Leu Tyr Phe Ala Ser Pro Phe Gly Pro Ser Pro Asn Gly 65 70 75 80 ccc aga tca ggt ctt ata tct gta gca att act ctg cat cct aca gct 289 Pro Arg Ser Gly Leu Ile Ser Val Ala Ile Thr Leu His Pro Thr Ala 85 90 95 gct gag aac att agc agt gtt gtg gct gca ttt tcc gac ctt ctt cac 337 Ala Glu Asn Ile Ser Ser Val Val Ala Ala Phe Ser Asp Leu Leu His 100 105 110 gtc cga atc cct aac agc tat gag gtt agc agt gct cca gat gtc cca 385 Val Arg Ile Pro Asn Ser Tyr Glu Val Ser Ser Ala Pro Asp Val Pro 115 120 125 tcc atg ggt ttg gtc agt agc cac aga atc aac ccg ggt ttg gag tat 433 Ser Met Gly Leu Val Ser Ser His Arg Ile Asn Pro Gly Leu Glu Tyr 130 135 140 cga cag cat tta ctt ctc cgt ggg cct ccg cca gga tct gca aac cct 481 Arg Gln His Leu Leu Leu Arg Gly Pro Pro Pro Gly Ser Ala Asn Pro 145 150 155 160 ccc aga tta gtg agc tct tac cgg ctg aag cag cct aat gta cca ttt 529 Pro Arg Leu Val Ser Ser Tyr Arg Leu Lys Gln Pro Asn Val Pro Phe 165 170 175 cct cca aca agc aat ggt ctt tct gga tat aag gat tct agt cat ggt 577 Pro Pro Thr Ser Asn Gly Leu Ser Gly Tyr Lys Asp Ser Ser His Gly 180 185 190 att gca gaa agc gca gca ctc aga cca cag tgg tgt tgt cat tgt aaa 625 Ile Ala Glu Ser Ala Ala Leu Arg Pro Gln Trp Cys Cys His Cys Lys 195 200 205 gtg gtt att ctt gga agt ggt gtg cgg aaa tct ttc aaa gat ctg acc 673 Val Val Ile Leu Gly Ser Gly Val Arg Lys Ser Phe Lys Asp LeuThr 210 215 220 ctt ttg aac aag gat tcc cga gaa agc acc aag agg gta gag aag gac 721 Leu Leu Asn Lys Asp Ser Arg Glu Ser Thr Lys Arg Val Glu Lys Asp 225 230 235 240 att gtc ttc tgt agt aat aac tgc ttt att ctt tat tca tca act gca 769 Ile Val Phe Cys Ser Asn Asn Cys Phe Ile Leu Tyr Ser Ser Thr Ala 245 250 255 caa gcg aaa aac tca gaa aac aag gaa tcc att cct tca ttg cca caa 817 Gln Ala Lys Asn Ser Glu Asn Lys Glu Ser Ile Pro Ser Leu Pro Gln 260 265 270 tca cct atg aga gaa acg cct tcc aaa gca ttt cat cag tac agc aac 865 Ser Pro Met Arg Glu Thr Pro Ser Lys Ala Phe His Gln Tyr Ser Asn 275 280 285 aac atc tcc act ttg gat gtg cac tgt ctc ccc cag ctc cca gag aaa 913 Asn Ile Ser Thr Leu Asp Val His Cys Leu Pro Gln Leu Pro Glu Lys 290 295 300 gct tct ccc cct gcc tca cca ccc atc gcc ttc cct cct gct ttt gaa 961 Ala Ser Pro Pro Ala Ser Pro Pro Ile Ala Phe Pro Pro Ala Phe Glu 305 310 315 320 gca gcc caa gtc gag gcc aag cca gat gag ctg aag gtg aca gtc aag 1009 Ala Ala Gla Val Glu Ala Lys Pro Asp Glu Leu Lys Val Thr Val Lys 325 330 335 ctg aag cct cgg cta aga gct gtc cat ggt ggg ttt gaa gat tgc agg 1057 Leu Lys Pro Arg Leu Arg Ala Val His Gly Gly Phe Glu Asp Cys Arg 340 345 350 ccg ctc aat aaa aaa tgg aga gga atg aaa tgg aag aag tgg agc att 1105 Pro Leu Asn Lys Lys Trp Arg Gly Met Lys Trp Lys Lys Trp Ser Ile 355 360 365 cat att gta atc cct aag ggg aca ttt aaa cca cct tgt gag gat gaa 1153 His Ile Val Ile Pro Lys Gly Thr Phe Lys Pro Pro Cys Glu Asp Glu 370 375 380 ata gat gaa ttt cta aag aaa ttg ggc act tcc ctt aaa cct gat cct 1201 Ile Asp Glu Phe Leu Lys Lys Leu Gly Thr Ser Leu Lys Pro Asp Pro 385 390 395 400 gtg ccc aaa gac tat cgg aaa tgt tgc ttt tgt cat gaa gaa ggt gat 1249 Val Pro Lys Asp Tyr Arg Lys Cys Cys Phe Cys His Glu Glu Gly Asp 405 410 415 gga ttg aca gat gga cca gca agg ctact ctt gac ttg gat ctg 1297 Gly Leu Thr Asp Gly Pro Ala Arg Leu Leu Asn Leu Asp Leu Asp Leu 420 425 430 tgg gtc cac ttg aac tgc gct ctg tgg tcc acg gag gtc tat gag act 1345 Trp Val His Leu Asn Cys Ala Leu Trp Ser Thr Glu Val Tyr Glu Thr 435 440 445 cag gct ggt gcc tta ata aat gtg gag cta gct ctg agg aga ggc cta 1393 Gln Ala Gly Ala Leu Ile Asn Val Glu Leu Ala Leu Arg Arg Gly Leu 450 455 460 caa atg aaa tgt gtc ttc tgt cac aag acg ggt gcc act agt gga tgc 1441 Gln Met Lys Cys Val Phe Cys His Lys Thr Gly Ala Thr Ser Gly Cys 465 470 475 475 480 cac aga ttt cga tgc acc aac att tat cac ttc act tgc att aaa 1489 His Arg Phe Arg Cys Thr Asn Ile Tyr His Phe Thr Cys Ala Ile Lys 485 490 495 gca caa tgc atg ttt ttt aag gac aaa act atg ctt tgc ccc atg cac 1537 Ala Gln Cys Met Phe Phe Lys Asp Lys Thr Met Leu Cys Pro Met His 500 505 510 aaa cca aag gga att cat gag caa gaa tta agt tac ttt gca gtc ttc 1585 Lys Pro Lys Gly Ile His Glu Gln Glu Leu Ser Tyr Phe Ala Val Phe 515 520 525 agg agg gtc tat gtt cag cgt gat gag gtg cga cag att gct agc atc 1633 Arg Arg Val Tyr Val Gln Arg Asp Glu Val Arg Gln Ile Ala Ser Ile 530 535 540 gtg caa cga gga gaa cgg gac cat acc ttt cgc gtg ggt agc ctc atc 1681 Val Gln Arg Gly Glu Arg Asp His Thr Phe Arg Val Gly Ser Leu Ile 545 550 555 560 ttc cac aca att ggt cag ctg ctt cca cag cag atg caa gca ttc cat 1729 Phe His Thr Ile Gly Gln Leu Leu Pro Gln Gln Met Gln Ala Phe His 565 570 575 tct cct aaa gca ctc ttc cct gtg ggc tat gaa gcc agc cgg ctg tac 1777 Ser Pro Lys Ala Leu Phe Pro Val Gly Tyr Glu Ala Ser Arg Leu Tyr 580 585 590 tgg agc act cgc gg gcc at tgc cgc tac ctg tgc tcc att 1825 Trp Ser Thr Arg Tyr Ala Asn Arg Arg Cys Arg Tyr Leu Cys Ser Ile 595 600 605 gag gag aag gat ggg cgc cca gtg ttt gtc atc agg att gtg gaa cag 1873 Glu Glu Ly Glu Pro Val Phe Val Ile Arg Ile Val Glu Gln 610 615 620 ggc cat gaa gac ctg gtt cta agt gac atc tca cct aaa ggt gtc tgg 1921 Gly His Glu Asp Leu Val Leu Ser Asp Ile Ser Pro Lys Gly Val Trp 625 630 630 635 640 gat aag att ttg gag cct gtg gca tgt gtg aga aaa aaa gtc 1963 Asp Lys Ile Leu Glu Pro Val Ala Cys Val Arg Lys Lys Val 645 650 tgaaatgctc cagcttttcc cagcgtattt aaaaggagag gatctgtgtgtggcctaccgt ctctgcagtg gcacgcatag cggaatcact tcctggggtt gaggcatgtg aaaattatac 2083 cttccgatac ggccgaaatc ctctcatgga acttcctctt gccgttaacc ccacaggttg 2143 tgcccgttct gaacctaaaa tgagtgccca tgtcaagagg cctcacacct taaacagcac 2203 cagcacctca aagtcatttc agagcacagt cactggagaa ctgaacgcac cttatagtaa 2263 acagtttgtt cactccaagt catcgcagta ccggaagatg aaaactgaat ggaaatccaa 2323 tgtgtatctg gcacggtctc ggattcaggg gctgggcctg tatgctgctc gagacattga 2383 gaaacacacc atggtcattg agtacatcgg gactatcatt cgaaacgaag tagccaacag 2443 gaaagagaag ctttatgagt ctcagaaccg tggtgtgtac atgttccgca tggataacga 2503 ccatgtgatt gacgcgacgc tcacaggagg gcccgcaagg tatatcaacc attcgtgtgc 2563 acctaattgt gtggctgaag tggtgacttt tgagagagga cacaaaatta tcatcagctc 2623 cagtcggaga atccagaaag gagaagagct ctgctatgac tataagtttg actttgaaga 2683 tgaccagcac aagattccgt gtcactgtgg agctgtgaac tgccggaagt ggatgaactg 2743 aaatgcattc cttgctagct cagcgggcgg cttgtcccta ggaagaggcg attcaacaca 2803 ccattggaat tttgcagaca gaaagagatt tttgttttct gttttatgac tttttgaaaa 2863 agct tctggg agttctgatt tcctcagtcc tttaggttaa agcagcgcca ggaggaagct 2923 gacagaagca gcgttcctga agtggccgag gttaaacgga atcacagaat ggtccagcac 2983 ttttgctttt ttttcttttc cttttctttt ttttttgttt gttttttgtt ttgtttttcc 3043 cttgtgggtg ggtttcattg ttttggtttt ctagtctcac taaggagaaa cttttactgg 3103 ggcaaagagc cgatggctgc cctgccccgg gcaggggcct tcctatgaat gtaagactga 3163 aatcaccagc gagggggaca gagagtgctg gccacggcct tattaaaaag gggcaggccc 3223 tctaacttca aaatgttttt aaataaagta gacaccactg aacaaggaat gtactgaaat 3283 gacttcctta gggatagagc taagggataa taacttgcac taaatacatt taaatacttg 3343 attccatgag tcagtttatt gtagtttttg atttctgtaa aataagagaa acttttgtat 3403 ttattattga ataagtgaat gaagctattt ttaaataaag ttagaagaaa gccaagctgc 3463 tgctgttacc tgcagaacta acaaaccctg ttactttgta cagatatgta aatattttga 3523 gaaaaaatac agtataaaaa tagttattga ccaaatgcta ccaggctctg cagcagctcg 3583 ggggcttata aaatgttcat agggatgtta caatataatt ttgtgttata aaatatgcca 3643 ttataattat gtaataacca aaatttcaac ctagagtgtt gggggttttt tggaaaccgc 3703 agtctattag tactcaatgg ttttatacac cttacttctg acagagcggg gcgtatgcta 3763 cgactacaac ttttatagct gttttggtaa tttaaactaa ttttttcata ttatattgtt 3823 gcatccctac ttcttcagtc aggttttttt gtgcttacaa tttgtgataa ctgtgaataa 3883 ctgcttaaaa atacacccaa atggaggctg aattttttct tcagcaaaag tagttttgat 3943 tagaactttg tttcagccac agagaatcat gtaaacgtaa taggatcatg tagcagaaac 4003 ttaaatctaa ccctttagcc ttctatttaa cacaaaaatt tgaaaaagtt aaaaaaaaaa 4063 aggagatgtg attatgctta cagctgcagg actctggcaa tagggttttt ggaagatgta 4123 attttaaaat gtgtttgtat gaactgtttg tttacatttc tttaataaaa aaaacactgt 4183 tttgtgtttg cttgtagaaa cttaatcagc attttgaacc aggttagctt tttattttgt 4243 acttaaaatt ctggtactga cacttcacag gctaagtata aaatgaagtt ttgtgtgcac 4303 aattcaagtg gactgtaaac tgttggtata ttcagtgatg cagttctgaa cttgtatatg 4363 gcatgatgta tttttatctt acagaataaa tcaattgtat atatttttct cttgataaat 4423 agctgtatga aatttgtttc ctgaatattt ttcttctctt gtacaatatc ctgacatcct 4483 accagtattt gtcctaccgg gtttttgttg ttttctgttc tgtataatag tatctaatgt 4543 tggcaaaaat tgaa tttttt gaagtataca gagtgttatg ggttttggaa tttgtggaca 4603 cagatttaga agatcaccat ttacaaataa aatattttac atctat 4649 <210> 149 <211> 3848 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (235) <400> 149 g ccg gaa ccg cgc ggg tcg tcg cag ctg cgg gtg aac gcg gcg ttt gcc 49 Pro Glu Pro Arg Gly Ser Ser Gln Leu Arg Val Asn Ala Ala Phe Ala 1 5 10 15 gcg cgg tac aac cgc tac cgg cgc gag gaa ctg cag cgg ctg aag 97 Ala Arg Tyr Asn Arg Tyr Arg Glu Arg Glu Glu Leu Gln Arg Leu Lys 20 25 30 gat cgc tac ggg gac cga gac agc agc agc gac tcc agt tcc gag tcg Asp Arp Arg Asp Ser Ser Ser Asp Ser Ser Ser Glu Ser 35 40 45 gac tca agc gac gag cgc gtg gtg cgc gtc ccc gcc ccg tcc tgg acg 193 Asp Ser Ser Asp Glu Arg Val Val Arg Val Pro Ala Pro Ser Trp Thr 50 55 60 tgc gga ggc gtc caa gcc ccc cac tgc acc ccg acc ccg atg 235 Cys Gly Gly Val Gln Ala Pro His Cys Thr Pro Thr Pro Met 65 70 75 tagacggggg ggaaccccca accccagagc gccctgcggg agcgtcccat cctccgctcc 295 ccatcccatg agggacagac agtgcccccc ctctccccag gggagccaaa tccccgttat 355 tttctctccc ctgccacgat ccccacctgc ccactctgat gtgtggggcg actctgtccc 415 ccaagaaccc cccctttcct ctttcatcct caagagtcta gccatttttt agtgtactcc 475 ttgcgccacg tggggcgc cc aacttctcac atcagccctg atcctggccc cactgtgcgg 535 cctggcccag cccctccccg ctgtctctct tgtgccctca gcccacctgc cccttgtcaa 595 gtctttgtct tccccaggaa ttaccttctc cttgcccctc accttcctct acccatatcc 655 tgtacctacc tgtggcctgc ccctgcccac cccaagaggg cccctctccc tcctgctgtt 715 tgaccacctg tttgacctcc ccagccagat ccacccccct ccatcctaat ccctacgctg 775 agctcacctg ctggcgccag ggctcttatt atctcccttc tgaaatctat ccccaaccct 835 tttcctgccc taggaatttg atccccagca ggagcgggac ttttacaaaa cgctctcctt 895 gttgaagaag aaggaccccc gcatttatca gaaagatgcc accttctata acagaacagg 955 tccggggcca ctcctgtcta aacctctcct tcctctggag cagaatccgg ggtcctttcc 1015 tgactgtgga ttcagagaag tgacttgact tctctgagcc tcttttcctg tctgtaaagt 1075 atatctaacg gtagcatctc ccctcagggc tgttttaagg atagattggg atttacccag 1135 tttacacagt tcatctgttt tgactattga atgaattgct tcacaagtca caagtcctta 1195 gcagagccta ggttattacc tggtggtggg gttaatgact gtgtccttgg cactattcaa 1255 ggtgggaatt gctgactgaa tgattccaac tccaccaggc tgggcaggtg gttcaagcat 1315 ctaatcccag cactttggga ggctgaggtgggagggtcaa ttgaggccag gagtttgaga 1375 ccagtttggc caacatagca agaccccatt tctctttttt ttttttgaaa tggagtttca 1435 ctcttgttgc ccaggctggg ttgcaatggg acgatctcgg ctcactgcag cctccgtctc 1495 ccaggttcaa gcgattctcc tgcctcagcc tcctgagtag ctggaattac aggcacgcgc 1555 caccacgccc agctaatttg ggatttttag tagagacagg gtttctccat gttggccagg 1615 ctggtctcga actcccaact tcaggtgatc cgcccaccct ggcctcccaa agtgctggga 1675 ttacaggcgt gagccactgc gcccagccag cctttctttc ttttttcttt tttttttttg 1735 agacggagtt ttgctcttgt tgcccaagct ggagtgcaat ggcgtgatct gggctcgctg 1795 cagcctccgc ctccccggtt caaccgattc tcctgcctca gcctcctgag tggctgggat 1855 tgcgggtgcg tgccaccacg cccagctact ttttgttatt tttagtagag atggggtttc 1915 accatgttgg ccaggctggt ctcgaactcc tgacctcagg taatccatcc gccttggcct 1975 cccaaagtgc taggattgca ggtgtgagcc actgtgcctg gcggcaagac cccatctcta 2035 caaaagattc agaactcagc tgagcatgct ggtgtgcgct tatagtccca ggtatttggg 2095 aggctgaagt gggaggattg cttaagccca tgagttcaag gctgcagtga gctgtgggct 2155 aggatgttga cactgcactc cagcctgagc aagag taaga ctccaactct caaaaaaatt 2215 aattataata attaatcagg ctgggcatgg tggctcatgc ctgtaatcct ggcactttgg 2275 gaggttgagg cgggaggatc acttgaggtc aggagttcga gaccagcctg gccaacatgg 2335 tggaacccca tctctactaa aaataacaaa aattagctgg gcgtggtggt gcacacccgt 2395 gatcccagct actcaggagg ctgaggcagg ggaatcgctt gaacctggga ggcggaggtt 2455 gcagtgagcc aagatcacgc catgcactgg gcaacggagt gagactctgt ctcaaaaaaa 2515 taataataat ggccgggtgc ggtggctcac gcctgtaatc tcagcacttt gggaggccga 2575 tgcaggcaaa tcacctgagg tcaggagttc gagaccaacc tgaccaacat ggagaaaccc 2635 catctctact aaaaatataa aaattagccg ggcgcggtgg tgggcacctg taatcccagc 2695 tgcttgggag gctgagacat gagaacggct tgaacccggg aggcagaggt tgcagtgagc 2755 cgagatcgtg ccattgcact ccagcctggg caacagaatg agactccacc tcaaaaaaaa 2815 ataagtaaat aaataataac aacaataata ataatcaaag caggaattac tgactgaatg 2875 accccaaccc caccagatgg tgacaagcac aatactcttg gacagctggg aattggtgga 2935 tttgggattt gaatcctctg tctaaccctg gccctgccct gtgggattct ctgccacggc 2995 aaagaagggg gttgtgggtg atggcaggtg tctttggtgg gttaacagca tcgtcatcag 3055 acagtgagga ggacccagaa gccttggaga agcagaagaa agtgcggccc atgtacctga 3115 aggactacga gaggaaggtt atcttggaga aggcagggta tggagaaggc ctacatcccc 3175 accccctggt tcccagccct gtcaggtcta tgggggtctt aggggcagga gagggaaaaa 3235 agctggcagc ctgggccggg catggtggct catgcccata atcccagcac tttggtaggc 3295 tgaggcaata ggatcgcttg aggacagaag tttgagacca ggctgggcaa cataccccgc 3355 ctctacaaaa aaattaaaaa ttagctgggc atgatgatgt gtacctgtag tcccagctac 3415 tcaggaggct gaggcaggag gattgagcca ggagatggag gctgcagtga gctatgatca 3475 ggccactgca ctccagcctg ggcaacagaa taagaccctg tctcaaaaag aaaaaaggcc 3535 gggcatggtg gctcatgcct gtaataccag caccttggga ggctgaggcg ggcagatcac 3595 ctgaggtcaa gagtttgaga ccaccctggc caacatggtg aaaccccgtc tctactaaaa 3655 atacaaaaat tagccagatg tggtggtggg cgcctgtagt cccagctacg tggggaggct 3715 gaggcaggag aatcgcttga atctgggagg tggaggttgc agttttccga gatcatgcca 3775 ctgccctcca gcctgaggga tagagcgaga ccctggctca aaaaagaaat gctgtcaccc 3835 atgattggaa aag 3848 <210> 150 <211> 6843 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (6088) .. (6468) <400> 150 gacaaatctc agcctgaccc taaagactac ctccatcctc aaagtaaatg gggttaaggg 60 ggaagaagtc aaccagccag gtgccgggga gttacggctt tcaggtgcag gttttccagg 120 cccctaggtg atgctaggtg ctgcagtgga atgggtggat gagcagagga ggatgacaca 180 cacacggagt agaacacacc acacacacac acacacgcgc acgcacacac acacacacac 240 acacacaggg gagaaaggag gaatgctaag gaaatgccct gtgatcatgc cctgagggag 300 tgaggaaggg cttgggcaca ggagccagcc tcagagacgg cctgaatagg atgagagggc 360 tgactctgct gagccaggaa cgacacctac actccacctt cataggaatc agaaaagcac 420 ccactctcag tgttagaagc ttgcaccacc ccccacacca aaaaatcccc tcaaggccct 480 gattcccttg ggctctaaaa caaacaaaaa agctaatggg tttcccagga agccatgtgg 540 taggatggat atcacagaaa actatggttg cgagaacttc ccttgggccc atgcgcagaa 600 caggaagtca ggcagtgagt gggctcccag gaagttaata tacactatgg acaggtagca 660 agttatggac agatagcaag atagccagtt aatatactct atggatgacc cagcaagttt 720 gctgtttcag aatcctcctc ttctgttttt tgaactttcg aaaacaaaag atatgctggg 780 agacgcggcc cctagagtgt gcttactcca ggtccttgat tgtccagact gtggaggggg 840 aagggcagat ctatgccaag aggggaacag gctgtagagg ccacagctga ttcatttttg 900 tgaccttagc actctgccca gcacctggaa tatagtaggt gctccataaa cctgtgttca 960 aggagagaat ctgtccatag catatgtatt aatgggacct ttatagtcaa tggacatcct 1020 tagaaatcac atacccatcg ttggctggtg gttgagaaaa aaaggtaaaa aatgagatac 1080 acccttctac atgtttggcc tccaatatgg ggccgggctg ggcctcgaga aggagaccgc 1140 aggacctcac cagcaaggca tcgtgtcctc tttgtgtcct gagatgcctt ctcactaagc 1200 ctctttccag acctttggtc ctggggatct gcagtgagca gagaggcagc tccttgcggg 1260 tgaaacccag caccggcctg caaggccaag cctccccatg ccaacacagc ttatttcctc 1320 tttcactacc tcactcccta gtggaaaaaa caagaaaaca aaattcccct gagcaatctg 1380 aaaccctgtg accccctggc caagtggcag atccagctcc accttgatcc cctccacttt 1440 cctctggctc acctatactt aagcgcagag gccagcctcg aggttattta taactgtgtc 1500 agaggaggag gaggcaggaa ataggaaatt atgcaggagg gggcgaggag tagctgcagg 1560 ggccaagtga ccccgctggc tggcttgaaa tccactacct gcctggcccg tggcttcaga 1620 gccccatgac agggaattct tacccagact ggattcctcc tggtctctga gccctacctg 1680 cgaatctctt gccagtc act tccccttctc cagatccagg tggaagcagt tttatcctga 1740 gactttcccc ctaggccggc cacagtgaca tcagcttttc tgactgcagt taatggtgca 1800 agagctggag gccaagcagg aggcccagcg ccggagggga gacaaacacc cagccctggg 1860 agcaaatggg gtggcggcaa acacacggcc ttttaagtcc accagcccta tccttctgtt 1920 tcctttcctc ctttaaatac tctgaaagcg agagtctgaa tagtgactac ttgagaaccc 1980 aagacttctc cttaacttca tccagaggac tcaaagggaa ggccactcaa ccagaatcac 2040 acagcagaag gagcagagcc aggcctgggg tcccattttc tggaggcact ggcccctttt 2100 tctacactac catgctgccc ccagcccctg ggctaactaa gactccccca ttctaaatgt 2160 gagtgcccct gatggaccgc ataggctgga tgtgcccgtc cttgctttgc ccagcagagc 2220 catgtccata aagatggcat cccacgtcaa atcctgtaga ctactgcaaa atatccatca 2280 gccaatttct tcaccaaaac gctctgagca gccactgaac tggcagtgcc attaattttc 2340 agacaatttc agactaagtt aggttacctt tttgggggga ttttgttgct gtttagtttc 2400 aacaccatta ttgactcagt gatactctag ggcaagtgtt ctaatgatcc aagatagctt 2460 ttaggagaat ttctgaagct cttgaaattt gtatgcatag ctttaatcag aatcccaaag 2520 gtgctcctat cggtaaaatg a ttaggtagg acggtgatgt aagagaagta tagaacagag 2580 aggggagaga tctggcccag acgaccaggg gaccagggtg gggttgcacc ggtatgtccc 2640 ctactgttca ttacctgctc gcagggtgcc tgccccatgg accttcaatc agaaacatct 2700 caccttcaca ctcaccacaa tgtccttcaa tcatgtcctt aacggtataa acaagatcct 2760 aggatttaaa aatctgatgt gtgcccagaa ctgagccaag caagattata aaacaagtca 2820 tgaccacagg aaggaacttt aaatctggca aatgtgtgac cttgaaggtc agccttccct 2880 tcctcctttt tcttctggtc cctacaaagc acccactggc accactacag ccatttctgt 2940 ttggcaaccc taggagagca gcttccctgt gtaatgcaga tgatacttcc taatttcttc 3000 ttccctactc agcaatcaca atggcaggca agtgggcaaa aggggttttc agaatcctca 3060 tctgggcagt gtctcaccaa ctgcatttgt aggtgcttct tgggaaaatt agttccttgg 3120 ctagatatgt tcagagaaca ctggattaaa cagagctaaa caggtcacca tgcagcagga 3180 cttctcagag cttttactat gctaatagcc acatgtctct ccaagagggg aatacaataa 3240 acagctctcc caaataacat tttttttttt ttgagatagg gtcttgctct gtcaccctgg 3300 ctggagtgca gtggtacggt cgtggctcac tgcagcctca acctcgtgga ctcgggcgat 3360 tctcccgcct aggcctcagg agtggct ggg actgcaggcc caaccacctt ttcttttttt 3420 tttttttaaa ttagtggaga cggggaatct tgctatgtgg cccgggctgg tcttcggttc 3480 ctgggctcgg gcgatcctct cgcctcggcc tcccaaggtg gggttgtatg cgtgagccgc 3540 tgtgcccggc tccaaagaac atttcttaag attggtggtg caaggatcac accttgagaa 3600 acactgattt aggccttccc acagtacaaa gaaatgttgc ctgccccatc cttacagcac 3660 acctgatgac ttacaagagg tgctgctgaa ttcctcccag ggaagcaacc ttaattcttc 3720 tcagcaagac aaggaggcag ccttcaggaa ggacccagga gcttggtatt agaggatgat 3780 ccaagtctga tggcaaattt agagtgctcc agggaacact gaagtcttga tgatagggca 3840 aaagggagtg attccatctt tctaacctgg caggatagca ggtaacaaga cagaaataag 3900 gaaaaggcaa gctgaacttg tctttccctg acatttgaac tgcctgctgt tctcctcacc 3960 aaaaataaaa aagctggtct caagacaaca aaagtagaga agtaaaggta acagaggtct 4020 ccagcctgca ggaagactca tataacctca gtccaaagtt ctttttatac aaagcacaga 4080 tttttactgg ctaagtgctc acccaatgac ccattttcag tatttgttta ttcctgtatt 4140 tcacccatgt ttatcgagca cctactgagt gtgtggcccg tagtcaggaa tgcccatcaa 4200 ttaccaggca gcaaggctat tcttagtttt c tgatgtcta tttaaagagt gttaatcctc 4260 tggcctcccc cctacccccg cccctgcaat tagacacata ccactttcca acctggtaca 4320 ctgacctcgc ccaactggga aggcggaatg gacaagtgtt cttcccaccc tgcttaactt 4380 ggccaagaat ctggcttcat gggttagggc agcctgggaa ccagccaagc cagaggagac 4440 gagcctgctt tgcctgggcc cttcaatcag tgctggggtc aaaaacctcc ctgttctgtt 4500 ccttactagt ggcacagtaa ggcagaaagt gttgagactc aagagcagaa aaatccaggc 4560 tgtctagtgg ggcggtgaag accacagacc acagaacaga cacacctgct caaatactag 4620 ctctgccatc atgcagtggg gtgaccgtgg gcagaattgg tgagattgct cggactctgg 4680 agtcaggagg tccggctcaa atctggcttc actatgtagg tacatactag gtaagttacc 4740 tagtctctct cagcttcagt attttcatct gcaaagtgga atgaggagga caaggatgat 4800 aacactaata atttctgaca tgtatgttta tagtaaagaa tagaatttat tacatgtata 4860 tatgtatata aagatcttaa aatagctgtc aacaaatagt agctgctttc atatttaatt 4920 cctcttaagt cccaattttt ttcatctgca aagtagaaat aggagtgcct acctcaatga 4980 gtggttatga gagtttaaag gagataatgc tttaaaaggt cttggcatat aaaaacaaat 5040 caataaatgt taaaatatta tcaaatggtt attatt tttg ttccagttcc atctctatct 5100 cttaaaccaa gctgctgtac ctctttggac ttcagtttcc ccatctgtca agtgagagac 5160 ctggatcaga tggcttctcc agtgtcaccg cacatgggtt ccctgcactg ggacccacaa 5220 ggcctagagg ttacttgcag caaagctgtc agtggcctct gagccttggt cagcccaaaa 5280 gtacctcgaa cagccccata tccctgtgca cagttcatga aactagaaat ggggagggga 5340 agatgccttg cctttgcaaa tgttatcttg acctgtgctg tagtattaac atggcggcca 5400 ctaaccacag gtagctgaaa cgcaactagt ccaaactgag atatgctatg agtgtaaaat 5460 acataatgga tgtcaaaaac ttaattttaa aaatattaag atcttattaa taagtgtaaa 5520 attgattaca tattgaaatg gtcatatttt atacatattg ggtttagtat taaaattaat 5580 ttcacttttt cctcgttttt ttaaacatga ctatgggaaa attcaaaatt gcatacatgg 5640 ctcacgtgta gccacaatcc tgtttctcct gagcaatatc aatctagttt ttttcccttt 5700 ctgtctcccc gcttgtgagc cacccagtaa gaaactcttc tcagagggat accagaagga 5760 attcgaacta tttgtaatta actttttgaa acaaaataaa atccagatgt taactatcca 5820 ggtggagcat tctattttag cagcctccag gaatctcctc tggcttaaag gagccctgaa 5880 taaataaaat ctatccagct gccaaagcac cccatgatgt t accatattt atcagcacct 5940 gaagttctaa atctccactc tggtcaagcc atctcttgtc tttctccgtt agaaaaagat 6000 gggcagtggt ttctgtttta ttttccaagg tacttgccac tgtttaatac ggtagcttag 6060 cagttaggaa tggccttttc tcattaa gct cag ctc cca atg ttt caa acc aat 6114 Ala Gln Leu Pro Met Phe Gln Thr Asn 1 5 ctc ttt ctt tct ttc ttt ctt tct ctc ttt ctt tct ctt tct ttc ttt 6162 Leu Phe Leu Ser Phe Phe Leu Ser Leu Phe Leu Ser Leu Ser Phe Phe 10 15 20 25 ctt cct ttc ttc ctt tct ttc ttt ctt tct ttc ttt ctt tct ttc ttt 6210 Leu Pro Phe Phe Leu Ser Phe Phe Leu Ser Phe Phe Leu Ser Phe Phe 30 35 40 ctg tct ctc tct ctc tct cct tcc ttc ctt ccc tct ctc cct ctc tcc 6258 Leu Ser Leu Ser Leu Ser Pro Ser Phe Leu Pro Ser Leu Pro Leu Ser 45 50 55 ctc cct ccc tct ttc ttt ctt tcc ttc ttt ctt tct ttt ttt ttc ttt 6306 Leu Pro Pro Ser Phe Phe Leu Ser Phe Phe Leu Ser Phe Phe Phe Phe Phe 60 65 70 ctt tcc ttt ctt tgt ttt ctt tct ttc ttt ctt ttt ttt ctt tct ttc 6354 Leu Ser Phe Leu Cys Phe Leu Ser Phe Phe Leu Ser Phe Leu Ser Phe 75 80 85 tct ttc tct ctc tct ctc tct ctc tct ctc tct cac aca cac aca cac 6402 Ser Phe Ser Leu Ser Leu Ser Leu Ser Leu Ser His Thr His Thr His 90 95 100 105 aca cac aca cga gta ttg cct gga aag gct gga atg ctg tct ttc tca 6450 Thr His Thr Arg Val Leu Pro Gly Lys Ala Gly Met Leu Ser Phe Ser 110 115 120 aat gtt ctt att cat tca tgatactttt attgaatgcc tactaacatc 6498 Asn Val Leu Ile His Ser 125 aggcaatgag ctggtgag gag agacttggag cccatccagag ctg aatgagccag 6618 gccttttatt tccattgtgt ctgtgaattc ttccacaacc tatgaggtta agagtactat 6678 tattgcatac tccattttac agataggaaa aatgagacca gggaattaac ttgtccaggg 6738 acaggcaact agccgagac gagcgag tggcagca tggcagca tggcctagcc taggatgcctagcc tggattg <210> 151 <211> 6381 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2405) .. (2941) <400> 151 agcgtgcagg tggccgtcct gggaactgga cactccttcc cttgagtccc tccctgccac 60 ccgcccttcc ggcaggctct ttgctgcctc agatcggcac ttactgggcc tctcggtgtg 120 gaggatctac tgtgcctggg gacagtttga ggctgacctc tggccaggga ttcctggagg 180 ctcttcctga gctgggacag ctggacatgg ccatgaggca gctgggctgt cctccctcaa 240 gagcagcccc agcctggacc cattgcttca gaagggacaa ttagacaggg agggtcagga 300 gaggagctgc aggagggcct ggggtcaagg ggacatctga gggagatgaa agtccctggc 360 cgggcgcggt ggctcatgcc tgtagtctca gcctcctggg tagctggggc tacaggcgcc 420 caccactaca cctgactaat ttttgtattt ttagtagaga cggggtttca ccatgtaggc 480 caggatggtc tcaatctcct gaccttgtga tccacctgcc ttggcctccc aaagtactga 540 gattacaggt gtgagccacc gcacctggcc agtatgtatt ttttctttag catattaaat 600 gttttgctgc ttcaggcttt ccagctaggt ttttttcttt ttttgcgtgt gaaacagggt 660 ctctctctgt tgcctaggag gagtgtggtg gtgtgatcat agctcactgc agcctccacc 720 tcccaggctc aatcaatctt cccatctcag ccttctaagt gctgggatta caggtttgag 780 ctactgtgcc cagccaagct agtttgttgt ttttaacata aaaatgatat ggatttgaaa 840 gttttaaaaa ttatggtgac atacacataa catcaaattc atcatcttaa gcattttaaa 900 gtatatagtt cagtggtgtt aagtacgttc atattgtaca agcagcatga ccatccatct 960 ctagaacttt tccattatct ccaaactgag ctctgtcccc attaaacact cactccctgc 1020 tgcccgggca ctcacccttc actgtgtgtc tctatggatc tgactcctcg agggacttca 1080 tgtaagtaga atcatgcagt gtttgtcctt ttgtgactgg ctcatttctc ttagcacaat 1140 gttttcaggg tgcatccatg ttgcagcatt tgttagagtt agcatttgtg tagcatgtgc 1200 cagcatttcc ttcctgttga aggctgagtt gtatgtgtgt ccattatctg tcagtggaca 1260 cttaggttgc ttccgtcttt tggctgttgt ggatcatgct gctgtgaaca tgggtgtgca 1320 caagccgcct gttttcagca cataaaaatg acacagagtt tttaaagttc tgtccagcct 1380 tctcgtggtt ttcagtgttt cccagtgggt ccctttgggc ctggcaggtc atcacatgcc 1440 aggagtggca ttttgcaggc ctttccagaa gtcacatttc gaaggcttcc aaagacatca 1500 cccttccagt gctgggcaga ggcctgggcg tttcccggcc aggcgtgggc tggctacaac 1560 ttgctgggca cagtctggtc tcaccttctt gctctctgtc aggtgtaggt ccggttttgc 1620 atggggcagt ggccgagcag gtgtggggag tgtggacaca gccaggggat acctgtgccc 1680 aggcctgggc cggggct gtc tgacgggact ggcaaggggc agctggagcc aacagggatc 1740 gcccagacac tgctctgtcc caggcctgct gcaaaggagg ccattgcaga tgggccgccg 1800 caaggagggc tgcgggtcct cgtcagggtg ggtggcggca cacacagcat gcctgctcag 1860 atgtcctacc cacctcggtg cctggccgtc tagtttaggc tcctagtttt cccaatcacc 1920 ctgtcaactt gcatgttgaa ggcgggagca acctagtcag tgttgttagt tctccgaggc 1980 ctttctgtgc tgagcctggt ccgttgtccc ctgcgagagc ccaagatcag agccagggtc 2040 cctctcagat cacctgcctc cacctccatc agctaaccgg gcttgcgtgg ggctggccag 2100 gggtcagtgt ctcctggggg agggctccca gaggcacaag ctgtgtcata gggtgatgca 2160 cttctgaagc agtcactcgg aatgggaaat cagaaaggaa accagcctgg agcggctgag 2220 gcttcacttt tgtgcagtgg acacaagcgc agaggtgatg accggggagg acctgagatg 2280 cctgagcgca cgcagggctc ttggcccgga ggtgatcagt cagcaagagc aatgttctca 2340 gccacgttgt aaaagtagat tttaagtaag tttattatga taaacactac gaaggattag 2400 gtaa cat ttt gga ctc tgg agt gta ctg atg gtt ctc atc cta aac tcc 2449 His Phe Gly Leu Trp Ser Val Leu Met Val Leu Ile Leu Asn Ser 1 5 10 15 act tta ttt ttc ttt caa a at tta tcc tcc tac tgt cat tcc caa ata 2497 Thr Leu Phe Phe Phe Gln Asn Leu Ser Ser Tyr Cys His Ser Gln Ile 20 25 30 aac tcc act cta aag ggg agg tgg cga gtt tct ccc tcc cac cgc gcc 2545 Asn Ser Thr Leu Lys Gly Arg Trp Arg Val Ser Pro Ser His Arg Ala 35 40 45 cta gcc ctc ctc ctc tgt ctg ctg aca cct ccg ttc acc cac agc ata 2593 Leu Ala Leu Leu Leu Cys Leu Leu Thr Pro Pro Phe Thr His Ser Ile 50 55 60 agg gag ctg ttg cca ttg aac cga ggg gca gcc ctc gac caa gcc cat 2641 Arg Glu Leu Leu Pro Leu Asn Arg Gly Ala Ala Lela Asp Gln Ala His 65 70 75 agg gat gta gca gac caa tgg gcc ggg ggc tgt gt ccc gga aag ccg 2689 Arg Asp Val Ala Asp Gln Trp Ala Gly Gly Cys Val Pro Gly Lys Pro 80 85 90 95 ggg cgt cag cct ggc agg caa caa gcg agg ccc ctc cct act cag cag 2737 Gly Arg Gln Pro Gly Arg Gln Gln Ala Arg Pro Leu Pro Thr Gln Gln 100 105 110 agc tgc ggt ggc ctg cac gcc cat cct ccc ttg cta gga gtc tgt ttt 2785 Ser Cys Gly Gly Gly Gly Leu His Ala His Pro Pro Leu Leu Gly Val Cys Phe 115 120 125 att ttt ttg tac ttt c aa aat gag cat ccc cca gac agt ctg cct ggc 2833 Ile Phe Leu Tyr Phe Gln Asn Glu His Pro Pro Asp Ser Leu Pro Gly 130 135 140 atg att gat gct ggg ggt gga agc ttt tcg cag tcc ttg gcc tct gac 2881 Met Ile Asp Ala Gly Gly Gly Ser Phe Ser Gln Ser Leu Ala Ser Asp 145 150 155 cct gct tcc cga ggg cgg cgc ggc ttc tgc gcg cct gct ggg ggc cgc 2929 Pro Ala Ser Arg Gly Arg Arg Gly Phe Cys Ala Pro Ala Gly Ar 160 165 170 175 tcg ggc atg tgc tgacttcgct gctgctcaga gccaggtttt gtaaacattc 2981 Ser Gly Met Cys aggagccact tcccaggtca gcaactgcga gcgtttttct gctggtttgt acgataagcc 3041 tttaaccaag ctttatttct acttgcaata aaggatgatc cactctggga ggttaaaata 3101 aagcgcccta ggggcggcac agctggcaat gccaacatct ccgactctgc ttcctgtacc 3161 gggcgtgcac tacgtccgca caagctgggc tccgacagga aggggggatg cctccgtgcc 3221 cggtgcacac acacacagaa ggggcccagg tgctgcacag agctcccgtg tggggccgag 3281 tgctggccct gcccgttgcc cgtgtgcctg gcgcctggcc gcagctggcg aggaccatgg 3341 acattggcat tgcgaagtgg gccctgcagt ctggaagcag aggaggacca gagccccttc 3401 ctcg acgcag ccttgatctc cacgtggtgg attaaacata ttagcagtta aagcagttaa 3461 ttgctgtgca gggggccccc gctcattgtt tgtctctgaa tcacccgccc acaccaggtg 3521 tctcagataa tagactggga acttcagtga ggaggatttc ctgtctgcag atgtgccgat 3581 tacagcgctg agtgaagaca gtcagccagc actgctgcgg gctcgaattc gcccgctgag 3641 ttaaccagtt gtggcctgaa tccctggctg tctaggggag cagggccagg ctggggcatc 3701 ctgagcaaac gcctcccagt gcaggggctt ctaagtgcag ttaagtttag atttggtttt 3761 aaagaaggga cagactgcct ctggactgca gccctgaaaa actggaagtt gagatcttca 3821 tgtgcccctt tggcgtcccc agcccctctg gatggttctc tgtccctctc ttgagggtga 3881 gatgctgaag gctctggcgt atccctccct gcaccacagg agtcctgccc atggccagaa 3941 gagccagcag acacaggagg ggactcgcta aacctggggg tcccacagcc aggcagctgt 4001 tgtgcctgag tgccagggag ggtggccaca ggtctgcctg gggccttgag atatggcagg 4061 tgagacgaga cccagggaag gaatccgtct ggatcttacc ccagccactg aagctatttc 4121 ctctttgggc tttatcttag ataactcaga gatgtccacc tgtgtgtaaa ccagcatcag 4181 agcctgaaac acaacatgca tggagcatgg gagcttggct tcccggcttc ctcttggcac 4241 cacacagag g ccacccccac agcctgcccc tgtatagtct cccccatgtg gcacgtgtgc 4301 ctggaccaca gccagagaga ctggggtgcc caggagatga tgatgggggc tggcggtgcc 4361 caggagggga gctgttgcca gggtgggctg cagccctggg ctcctctctc cacccaggca 4421 ctgtttgctg gcatgtacgc ggcaggcaac tgtctttgct cagctgtgct cggctgatgg 4481 ctcccgtaca ccgcagactc agctacacaa gtccctgcgg attgtccctc tgttgagtgc 4541 caggcagcag gaaagggcag aaagcaagaa ccaagctggg gatgggtggg agcatcctaa 4601 gcctggtgag agggaagggg cggctcctcc tggatgccct ctgtgctggt gtgggtgcag 4661 ctggggctta ggggccgcgg tgggtgtgga tgctgcccgg gcgagggggc tgcggtgggc 4721 ccatcaggac tgctctcagg gatgcgcctt gctgcagctg cgtgaaacca agtttgtggc 4781 tatgctcttc ccggtgggga tgggcccagc agtgaccctg gcatccacat gcctccatgc 4841 tctcagggtg gagtggccat ccctgagcag gtgacacgga tcggaggccc ctctttgata 4901 gtctaacacc tttttatttt agtgcaaatt tagtttgtaa ttaatgacat caagagagac 4961 ccaaatctgc ctccattgtg agtttgatat tttttgaagt ggggccaaga tgaacattca 5021 tggagctctt cctatgagcg gtggctgcgg ccttcccctc cacaccacgt ggccccgggc 5081 gtgcgctgct gctc ctgaga cagcactgtt ggctcagccc tagctcatgg tggtgctaac 5141 acctcacaga ggccaggcca gagtagcagg aggcagcgcc ctgtgcttac ccaccagcct 5201 ggtgccccac gcttggcttg agggctagtt cacacttatg tccagagccc acagctatct 5261 gacaggccag ccggcacctg catacatggt tgtccaactg ggtcttgtta ccatgacaaa 5321 ttcagtactt aatgattaga actgagtgga aaccaattaa aaaaaaaaga acaacatggt 5381 gaaaagtctt ctagagatag gtcagcacca tttatgcata ttaccatgca ccctctaatg 5441 tctgcaggtg ccctggggca gccaacctgt tacaattgca attatgttaa caattgttaa 5501 agggccgggt gaggtggctc atgcctgtaa tcccagcact ttggaatgcc ggggtgggag 5561 gatcatttga gcccaggagt tcaagaccag cctgagcaac agagtgaaac ctcttttcaa 5621 ataattaata ataataataa taataataat tgttttttgt ttgtttttga gacggtgtct 5681 agctctgttg cccaggttgg agtgcaggag cgcgatctgg ctcaccgcaa cctccacctc 5741 ccgaattcaa gcgattctcc tgcctcagcc ttccaagtag ctgggattac aggcacccgc 5801 caccgcgccc agctaatttt tgtattttta gtagagacag ggtttcgctg tgttagccgg 5861 gctggtctcg aactcctgac gtcatgatcc gcccgcctca gcctcccaaa gtgttgggat 5921 tgcaggcgtg agccactgc a cccggtctaa taataactgt taaagcaata atgaccactc 5981 gccacagagc acgctccttc ctgggggtcc tctgggcctg agctgggggc tgcgccgtac 6041 tccaaggctg actgtggggt cttacacatc ataatgcaca taggcagctt gagtaggaaa 6101 ggcccttatg ctgcctgagg ggaagctcac ccccaccccc caaggagccg ccctgggtat 6161 gagacatccc tggaacggcc taggggtccc tggtggctgc tggcagtcac agcaagtggc 6221 caatcaggtc ccattgaggc ccaggggctc actcatttat tcaactaaca tggcgtctcg 6281 atgggacctg aggccagcag ggcaggtgcg tccccttccc cctggtgggc tcatagctgc 6341 gggtaggggc ccggggctca ttgagaaggt gcgattccag 6381 <210> 152 <211> 6799 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2204) .. (2545) <400> 152 ataagaataa aaattacccc aaatttccaa atcaagaagt aatcatggtt caggtttggg 60 cagatgttct ttctaggcat gaacacacgt tatctcattg tttacttaac accgggttat 120 aaacatttac ccatagcatt tgaaaggtag ctatagatag aaaagaatca gagaagttct 180 aaaacagctc ttgcgctttg tttcaaattc tctgcaggaa agatgaggtc ttcagccttt 240 tttttagctg gacggcaccg ttgcagcagt ggtgaacagg gcactggatt gagtcaggaa 300 acccagctgt gaccttgggc aagccacttg ccctctttga gcttcactcc tgctaaggca 360 aggggcgcta ttcgtaccct gtctgcccac ctcacaggct ctggtgaagt ccttgatttg 420 aacgccttta gctcccaagg ttgtggtttg gagatagggc aggtcacatg accatgaaga 480 ctgaaggaga aacgtggaag cacgtgtgcc tgttgcttct tttccaactt aaaatgcttg 540 gtgatctcct gaagactcca gcctcctctc tgggaagcca ggatccacag accctttacc 600 tgcgggtcat gggcagtccc agatggtccc cctccccaac agagggggtg cagtgagacc 660 tccggaagtt actgcctctg ttaccctcaa agggattttc agatcagaca gcccccctac 720 tccaagggac gtgtgtggag cttggtacct ttatttatct cctgctccaa cccctgtgga 780 ctgcctgcac ccagaatggg gcctgtcctg ctggcaagtg gctgagaacc tccactccac 840 tcagcagggc tgttccccat ttaccgaaaa gctccgagag aaaataacta accccatggc 900 gccgctgtag ctactggcag agcctcctgg tccccacctc tagcgcctgt ggtttttgtt 960 tcatgcagag tgagcagtga atctgggatc ccatcagcag tcagtttggg tgcctgcgag 1020 gcacaatgat agatgttggt gaagggtatg tgtgaggata ttaattaata ttaacatgct 1080 agttatatta atattctcat tggaatttgt ggggctttgc aagttatatt tcaaatatat 1140 ggttttatgt aatcctttta actgccctga aaccttgaaa ttattgcacc tattttatag 1200 atggagagac tgaggctcag aggggtgaat tgcctaagat cctgggggag gaagcaccca 1260 ggttttctgg ttttgagtcc tgggcccttc ctgctgagta gctaccccca acacagacct 1320 gcccttggag agcttgcagc cacactggga aggccagtgt attggattgc tgcttagacc 1380 tggaaagcac gtgaataaag cttcaggtta aaaccatggg ggttccagga ggcagcagtc 1440 ggctctgcct gggggtgagc tgaggagccg gtgctctctg gaacaagggt agttgggctg 1500 aggctcagtg gacagtggag gttggcaggt gaagtgcagg aggtctttgc agggagtggg 1560 accaccttga gcacacacag aggaatgaga caggcaggtt actcaaggag cagaggtctc 1620 gtgaccactt cccagagcat gtggggtcct agcctcatct ccaggaggag aaagtgcatc 1680 tatacacaga tttgtc aatg gagtttaaat aggatgtggg aaaatctaga ttttccaaaa 1740 cagtacatat ttgctttgag aagaaaggta gatgcaggat gcataggtta gataatttta 1800 atagcagtaa cctcagagca tgtaagtatg atttgattta ctggagtgcc tggccgtctc 1860 agtcagtggg agcacggctt gggctgggag atgaggttga caagggttct ttctctcaaa 1920 tgcttccttt ggtttgctaa gaggtatctc ctactcggcc gggggcagaa gacttttcct 1980 tcttttccca gtttgcagta gttgggccag atttgtggaa gtgggagaaa ggcctgccct 2040 gcttctacat agagttggct gtcctgactt gatactcggt gtgccttcca gagacccgcc 2100 tccatctcct caactccctg gcttgatgct taggtggtga tggctgttgg gcacaggagt 2160 tacataacag atctgtgatg gacccaggag cagagccagt tga gtg aat gtc atg 2215 Val Asn Val Met 1 gag tgg gag tgg tct tgc atg gct gtg gtg Tcc Tgt Gc Ag Tc Gc Gc Tg Cct Gc Gc Gc Gc Gc Gc Tg ccc gct A Ala Cys Ala 5 10 15 20 ggg tat gtg gca aga ggt gct cac cac tca tct gga atg gct aga ctg 2311 Gly Tyr Val Ala Arg Gly Ala His His Ser Ser Gly Met Ala Arg Leu 25 30 35 gaa gca ctt ggc cct ctt ggg ctc tgc acc ccc acc ccc tcc cac ctg 2359 Glu Ala Leu Gly Pro Leu Gly Leu Cys Thr Pro Thr Pro Ser His Leu 40 45 50 gcc tgc ctg ctc atc ttc atg ggc gcc tgg gga gac caa tta tgg ctg 2407 Ala Cys Leu Leu Ile Phe Met Gly Ala Trp Gly Asp Gln Leu Trp Leu 55 60 65 ctt gtc ata gtg gct cag gtc acc gtt cac act tcc tgg gac cag gac 2455 Leu Val Ile Val Ala Gln Val Thr Val His Thr Ser Trp Asp Gln Asp 70 75 80 atc aga gcc ctg aga agg gtc aag ggg cca agt ggg cct agc ctt tta 2503 Ile Arg Ala Leu Arg Arg Val Lys Gly Pro Ser Gly Pro Ser Leu Leu 85 90 95 100 ctg aca gct ggg aaa tgc aag cgt gtg gac cag agc acc aag 2545 Leu Thr Ala Gly Lys Cys Lys Arg Val Asp Gln Ser Thr Lys 105 110 tgagttgggg ccggtgtggg ttcagcaccg tgtccctacc cagagctcca tttgttgaaa 2605 acagcctttc tctaccgttt cttcacttgg acaactttaa actatgtatt ggctggtcgc 2665 ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggtgggcagg taacttgagg 2725 tcaggaggtc gagaccagcc tggccaacat ggtgaaacct catctctact aaaaatacaa 2785 aaattagccc agcgtggtga cacgcacctg taatcccagc tactcgggag gctgaggcag 2845 aagaatcgct tgaacttggg a ggcaaagat tgcagtgagc tgagattgca tcaccgcact 2905 tcagcctggg agacagagcg agactgcatc tcaaaaaaca aacagaaacc tacatatttt 2965 ctatatttcc cccaacattg aggctcattt cttggatgaa caatttaaat gtactgtgcc 3025 tctctggcaa tattttccaa aattacagat gtttctatac tttcaccggc agctctgcct 3085 cccagaattt attctacgga tgggttaaca cgtgtgcaaa atgatttatt tgcaaggttc 3145 gtcattgttg ccttattttt aatagcaaaa gattggaggc agcttaaatg ttcattcgca 3205 ggggccaatg aacaaaccat ggcccgtcta aacatgggat accgcgtggc cataatacat 3265 aagatggacg ctcaacgcac tgtgccggat tgagcagcaa ggtggattgc cgagggaaga 3325 agcaggtctg ggcggtgtgt ctcggagctg ccatcagtgt aaaagggaag agaatcaaaa 3385 gtgtcttgct tgtctatgcc cagggggtct ctgggcagac accgcaagtc ggtgattgtg 3445 atgcctctgg agggggtgct ggtcatggga gattgcttgt ttgctggaga tcccatgtac 3505 cttttgattg ctgaagcagg tgaatgtacg cctttccaag aaattaaaat gggccaggtg 3565 cggtggctca cgcctgtaat cccagcagtt tgggaggctg atgttggagg atcacttgag 3625 gtgaggggtt cgagaccggc ctggccaaca tgatgaaacc ccatctccac taaaaataca 3685 caaattagcc agacatggtg gtacatg cct gtaatcccag ctgctctaga ggctgaggca 3745 ggagaatcat gtgaacccta gaggctgagt ttacagtgag ccaagatcat gccattgtac 3805 tccagcctga gctacagagc gagactctgt ctcaaataat aaaataaaat aaattaaaaa 3865 cataaggact gtaaccttgc ctcctgccca gtgtaggaag gtcaaggttc tggctacttc 3925 tcaagtacag gagcctcact caggccccag accactaatc aaaaaatatg tgcttggttc 3985 tcacaaaggg gccgagtgtg agggcttggg tgttgcttgg taaatacgac ccccggtccc 4045 ggccttggag agatggagcc ctctctgggc cccttggaca cactgctgtt ggctgacttt 4105 gtcattttca acccttgctc cgattggctc acgtcatgat ttctgaaacc tttgggggct 4165 tccccactga cagaaagata cactttaact cagcactggg catcccaggc cctctttact 4225 gggcctcttc ttgagccgca cttggcctgt caccccttcc tctgtctgcc ctcttaactc 4285 cccacctccg tgcctttgct catatagttc cctttgcctg cctttccgtc cagagcagtc 4345 tccacgtgcc caggtcctgt ctgactttca agggccagct tagtttccac ttctgcactg 4405 ccttctgacc tccctggctt ctgtgtaaac tgcccagatc aagccacaca atggttcctg 4465 cacccaagga agctccctgg ggccccctcc tggccactcg ctcttcgccg gtagtcacca 4525 ctcacacctt ggcactttcg cgtggtgcct g ccgctgcct gtttgggcct cccacacaca 4585 gagtgtacag aacggactcc tcggtgtctg gctgccttcc cgcagcactg tcagatcatc 4645 caggttgcct gtagtggccc tttggttttt ttctctgctg cgtaggagtt caccaaatat 4705 accactattt attcattctc ctgtggacag gcattgggtt atgtccagcc tcttcggtga 4765 attcattctt gtctttgggg gcgcgtgtgc gctctttgct gggtatacac ccagggtggg 4825 ttgatggctt acctgactca gaatgtgttt gcatgaatga aattcaggtt ggtatgagaa 4885 atctagggtg tcctggctgg agccaggctt cttgattaca gggacagagc aggtacaggg 4945 atcctggttt agacagcctg ctcccatggg gtggtagcat tgttggggtg caggatgctg 5005 aatctgcagg ggacctatcc gctcagtgcc cagtgggatt ttagctggct ggaaaggtgg 5065 tcacatgtag aggggctcaa caatccagct aaagaggctg agcgttggtc cattgttctc 5125 aatttgagag aaaactgaga tcatcaaaat taggactggt atgtactaaa ggaaagaacc 5185 taattacaag gctgaattga gtaagccctc gctgagggac tttggatttc tttgttgttc 5245 ccctttattt ctgcaccccc acccaagtga cagatatgta catgattgga tgattttgct 5305 ttcctggttg agagattcct gggaacttgg cccaggagaa gggggagaaa tgtggagccg 5365 ctagagtggc ctccgcttgt ttgtgttgat tgaaggg gag acggaaggag agctgtggac 5425 ccctgacccc ttgtgagggc atgtgatcct tttcaaaagg ctcaccaggc agaagtgcct 5485 ggccaggggc cgctctttcc ctctaatccc ctctggagaa gggccaggct gtgggttgct 5545 gacctgctct gatgtggatc agcctccccc aataatgcag ctgcccagaa gctcagagag 5605 cccaggcaac ccccaaaggc aggagggccg gctgtcattc ccgttgtcat tcccaggcgg 5665 ctggagtggg agcagagcgg tcagttcaga tgaacagtgc tcgagtctga ccccaaccag 5725 cgagttatgg taagatggaa ggttctccat ctatattaaa taagagaaca aaagccctcc 5785 caggctgcat gaatattcca gggatatata tgtgaacggg ttgccagttt agcttggcct 5845 gtgggtggca gccgcctgag tgagcacttc gtggctgcag ctctaaaggg tttggatctg 5905 aaactaatga atgaaaatat gacctcagaa gatttaaaga gagcaaatac ccagcaacag 5965 aacctgggtc ccagagactg ttgggagcat gaaatcccag gctggccgaa ggaggaagtg 6025 ggagagcaat ggcagctgac atcacatggt gccagacctt ctcagtgctt tctgtgttca 6085 ctcattattc cgtccctctc tctcagaggc aggtatggct gcttccccat tttatagatg 6145 aggaagctaa ggcaaggaga ggttgtgtaa cttgctcaca gacacaaagc tagccagtgg 6205 caaagctgga ggtcaggtct aggtggtcag gctccagagt t ctgcggatt tcacagcacg 6265 gcagtggcag tcggaagaac catttgtcag gtgattgtgg gcaaatgacg tcagcccttc 6325 aaacctctgt tttgcatctg caagctgctt gctgctgcaa caaattacca gaaacttagt 6385 gacttaaaac acaaattagg tcgggtgcgg tggctcacat ctgtaatccc agcactttgg 6445 gaggctgagg tgagtggatc acttgaggtc aggagttcga gaccagcctg gccaacatga 6505 tgaaaccctg tctctaccaa aaatataaaa aattagccag gcatttggcc gggtgtggtg 6565 gatcacgcct gtaatcccag aactttggga ggacaaggtg ggcggaacac aaggtcagga 6625 gttcaagacc agcctgacca atatggtgaa agcctgtctc tactaagaat acaaaattag 6685 caggacgtgg tggcacgcgc ctgtagtccc agttactggg aggcggaggt tgcagtgagc 6745 caagatcacg ccactgcact ccagcctggg tgacagagtg agactccgtc tcac 6799 <210> 153 <211> 6855 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4465) .. (4692) <400> 153 aacatatatc ctgttcctta gatgttattt agcctcagag tgaactgtgt gatacacaca 60 caaacacaca caagtatata tgaagtttac actcttttgt tagtctcttg tgtagtgaat 120 ttatttttgt acacctgcta cccttctctt ttgtttgttt ttgttttttg agacagtctt 180 gctttgtcac ccaggctgga ttgcagtgat gcaaccttgg cccactgcag ccttgacccc 240 ctaggctcaa gtgatcctcc cgccttagtc ccccaagtag ctgggaccac aggcaagtgc 300 caccatgccc agctaatttt tttgtagaga tggggttttg ccgtgttgcc caggctgtct 360 gagatcaagt gatccaccag cctcagcctc ccaaagtgct aggattagag gcgtgagcca 420 cactgcaccc ggctccctgt acccttctta atacgaactt aaagtgttcg taatgagcca 480 accgttgtaa ggtttttgga cttcttataa aaagccagat tcaaatacag ttgtttagac 540 aaaaatgtct tagtatggaa atatgcatga gcatattttc ctgccagatt tgtggttaga 600 aaagaagcaa attttcctcc tagagtggaa ggaagaaaaa aacaataaag aaaagaagca 660 agctattcaa gaagaaggta gtatagtggt agctttttgt tgagaccagt caccagcctg 720 gaactttctt tggtaagtaa ttagattcat tgaataaaat gttcaaccga gcttggtgca 780 atctcatagt tacaaaacac tcttgccaaa gaaagttgca gtcttaatat ccgtaatcga 840 atcatttcct gttcgggctt gcaggtgggg aacaatctga aactgcagtc ctataagatt 900 agttataaag aaaacgcctt ggtgggagaa gccttgatga taatattgaa tagacagcct 960 aacaagtgtg gggatgaaga aggtacacca ggatcctggg actaaccaga tttaaaggcg 1020 taagtcggga tctgcaagcc cactcccttg gggtgatctg aataaagcta ctctagggca 1080 ttcaggtatg tgctgaacac actcgggcag tgggccaggc agatggctca ttcctgcacc 1140 gaccttcgaa ggcctgccag gttgaaaagc taccactggg gaggcatggc tgtgctctag 1200 caagaacaag aacatgcatt tcatgtagca tttggtcctt cccagttgag ggagatgcct 1260 taggactacg ttaatctctg agtccactta gggcttggga tgtattctca cagcccttgc 1320 tcctcctcca tcttagagtt tatttttacc gtcattgcaa cctcctctaa gtgattcttc 1380 cagacccata gttagccttt gagattccgc agttctcctc cctactcttc cccaccatgt 1440 cttcattgag acccacattt ttaggtttga ctaaaccttc catctaggaa taggtaggag 1500 gctaagcaat ttaggccgca ttcatgtatc ctgtcatttg cttcactgca tcttcttggc 1560 tgtggtaaag gaaatttagg tgtgatacac tccttaggct tccctgccct gccccccttt 1620 ccttttgccc ttttgatttt ttttaatctg atactcaggc tctcctcccg ccttcacaca 1680 ccattggagt ctcctaa gct atttctgtca gtttaatgat ccccagctgt tgccacagtt 1740 caggctgttt tcatgcccag gagaagcatc gaagaggcag aggaaaaggg gtcttgtttg 1800 ttgtctgtcc cacagtgtgt aaaacaaatc aaattcattt ttctgaaact actagtgaga 1860 ttccttaggg atggatgtta atactgggat gatttgaaaa tcaggaggag gaaaagtaca 1920 tggtagtatc agggacattt ttaaaataag cattctgctg ataggtgtgg cactctgcat 1980 cactcagaat tatgctagaa aattgaggta tgtggtatgg aggaattatt tgatcacttt 2040 gcattctttt agattttttt tttttttttt tgagacggag tctcactatg ttgccaggct 2100 ggagtgcagt ggcgcaatct cctctcactg caacctccta ctcccagatg caagcgattc 2160 tcctgcctca gcctcctgag tagctgggat ttacaggcac gtgccaccat gcccagctaa 2220 tctttgtatt tttagtagag acggggtttc accatgttgg ccaggatggt ctcgatctcc 2280 tgacctcgtg atccgcctgc gtcggcctcc taaagtgctg ggattacagg tgtgagccac 2340 cgcacccgcc tctactttta gattttgagc tggaatttcc cttctactca tgtatgttga 2400 aggagtatct aaattaaaag aattctgtaa taggaaatat atggaaattg tttctgaagt 2460 atccagaaaa ggcatttatt taagttctgc tttaacttaa tgcaggtttg tttcgtaaaa 2520 ttttgtgcaa aacctgcagt ag tgaaatgt tccatttgca aattcaacca cacagacttc 2580 aggaaataca aagttgcggt acttataaca tgaactcttc tacagttaca cctacctttg 2640 cttttgaaaa gtctttacta aacctggggg atgtggagtg ggaaaatcct acagtagtta 2700 aatgggctcc taatgtatta taatgatctg gcttctcctt tatgtgtttg atcttgagaa 2760 ttttaaccca ttccaacaag tttagctgat ttgtagcttt tacgctcaga cactacatga 2820 agtttaattt tatggatttc tttcttccac agagaagaca aattttgctg cagactttat 2880 caaattttat ttttaaattt ttatcttttt gagtcaaata gctaaaaatt tacatcattt 2940 aggactgaag agtgagaatt tactgttttt tttttcttta tccatagaaa acttgataca 3000 taaacatttg aataagcttc agattgtttg tctatctaat tatctatcta tctataaccc 3060 aacccatatg gtctaatttt taatcacctt tctattccct actgcttccc atagaaaagg 3120 gccaggtgta gtgcctcatg cccaatccca gcaaagcctg taatcccagc attttgggag 3180 gttgaggtga gcggatcact tgagtccagg agtttgagac cagcctgagc agcgtggtga 3240 aacaccatct ctacaaaaac aaacccccaa aaagcaaaaa ttggtcaagc atgctactgt 3300 gcgtctgtag tcccgattac tcaggaggct gaggtgggag gactgattga gtccgggagg 3360 tcaaggctgc agtgagccat gatcgca cca ctgtactcca tcctggcgac agaatgagac 3420 ctatcttttt atttttattt taattttttt tttttattga gacagtctca ctctgtcacc 3480 caggctggag tgcagtggca ctatctcggc tcactgccag ctctgcctcc tgggttcatg 3540 ccattctcct gcctcagcct cccgagtagc tgggactaca ggcgcccccc accacacccg 3600 gctacttttt tgtattttta gtagagatgg ggtttcacca tgttagccgg gttggtcttg 3660 atctcctgac ctcgtgatcc actcgcctcg gcctcccggg gtgctgggat tacaggcgtg 3720 agccattgcg cctggctgag accctatctt aaaaaaaaaa aaaaaaaatt actttaggtc 3780 tgtcatagtg gctcacgcct gtgattccag cactttggga gactgaagca ggaggattgc 3840 ttgagaccag gagtttgaaa ccagcctggg caatatagtg agaccccatc tctacaaaaa 3900 aattttttta aaattagcca gacgtggtgg agagcgcctg cagtcctagc tatttgggag 3960 gctgaggtgg aagaatcact tgagcccaga agtttgagat tacagtgagc tgtgatcctg 4020 cgccactgca ttccagcctc ggcaagagag tgagatcctg tctctgtgtt ttgttttttt 4080 gagacgggct cactcttgtt caggctggag tgccgtggcg cagtggtggc tcactgcagt 4140 ctgggtcaac aggcatacac tacaggcaca cacaaccagg tgttgtctcc ctgtgttgcc 4200 caggttggtc tccggctcca gctctcaagt aa tcctccca ccttgacccc cacaaagtgc 4260 tgggattata ggcacaaccc actgtccctg gcctaattta attttaagga aaacaatttt 4320 ttgtcacttt tggtttgctc tagaatgact accctattcc aagttttgaa tctgtacaac 4380 aaagttgggt gcagaatgtc agcatcagtg ataccagcag ggattagcaa atgagattca 4440 aggctgccca tattttctca gtga atg ggc aga act aat gca ata agg aaa 4491 Met Gly Arg Thr Asn Ala Ile Arg Lys 1 5 atg ctg ttc ttg gtg cct tta act ttg gaa ggg agt gtt cag atg gcc 4539 Met Leu Phe Leu Val Pro Leu Thr Leu Glu Gly Ser Val Gln Met Ala 10 15 20 25 cta cct aaa agt gct aaa gga agc aca ttc cta gtt tat cac cct 4587 Leu Pro Lys Ser Ala Lys Gly Ser Thr Phe Leu Val Tyr Leu His Pro 30 35 40 gtt cag gca tct ggt gca agt gca tgc tat gcc cag atc tta cat gat 4635 Val Gln Ala Ser Gly Ala Ser Ala Cys Tyr Ala Gln Ile Leu His Asp 45 50 55 gga gtt ggt tgc aca ttg ctt tat aga tcc tca gga aag aga ctg atg 4683 Gly Val Gly Cys Thr Leu Leu Tyr Arg Ser Ser Gly Lys Arg Leu Met 60 65 70 aca ttg aag taattggcac tttgacct attagaatag 4732 Thr Leu Lys 75 gaggtcacct caagggggga gatgagcagc tacccaaaat gaagtggtga gcttcagatt 4792 tttgaggatg tggggaataa tatttattta tagttattaa tatttttatt atgactgtgg 4852 cataaatgtg atatagtaga aaaagcacaa gctttgatat caggccaacc tgtgtttgaa 4912 ctctggctct acctgttacc acttgtgcag cttcttcatc tatgagatag tacatatctc 4972 aaatagccat tgagatgaaa tgagtcaccg tagtagtact tctacccagt gacaacacaa 5032 tgtaagagct aaacacatta gagtcctcat ttcttttttt ttttttttga gatgggagtc 5092 ttgctgtgtc acccaggctg gagtgcagtg gtgcgatctc ggctcactgc acgctctgcc 5152 tcccgggttc cagcgactct cctgcctcag cctcccgagt agctgggact acaggtgccc 5212 accaccacgc ccagccaact ttttgtattt ttagtagaga cggggtttca ccgtgttagc 5272 caggatggtc tcgatctcct gaccttgtga tctgcctgtc ttggcctccc aaagtgctgg 5332 gattacaggc gtgagccacc gcgcctggtc agagtcctca tttcttctat tttagttttc 5392 ttttcaaggc aagccttttc tcagtgcctt tgcacttgca atttcttatg tctggaatac 5452 tctccagatc atttttatgg tttgtcatat tatttaggtt tctgtccaag agtcatcggt 5512 ctcttcaaaa gggccttctc tgtgtaccct atctaaaatt atcaccaccc ctgtcactct 5572 c tgttctctt gttccactat atttttcttc acataatgta ctccctgaaa ttataatacg 5632 tacaccttat ttattatgtt ttccctgcta gagcatatgt tctatgaggg cagggacctc 5692 atctgtccat gttgttgttt tattgcctat aaatattgac cttatctgtt catgttgttt 5752 tatcacctgt aagtatcacc tatacatatt agttcaataa atgaatgaac gagccaactg 5812 acaatcttcc tagtgcccga aaagaacctg tggccgaatg caggaaggaa gttgtaccag 5872 gaagcaaatg ctctctgctt ttgtggagtg gatgttccca cactgagagc cagataggca 5932 gtagtcctgt gacgtcctct tacatccttt tagacttctt cctgtctctc tgtctgggaa 5992 gagccccttt gacctttatt tagtatttgt tgttattttt tgagacaggg tctcaccctg 6052 ttgcccaggc tagactgcag tggcataatc atggctcact gcagcctcaa cccctcagct 6112 tccggagcag ctaggactac aggcaaggac tactacacct ggctaatttt tttaaaaaat 6172 tattttttgt agaaacgggg gtctccctgt gttgctcaga aaagtcttga actctggccg 6232 ggcatgttgg ctcatgcctg taatcccaga tactcgggag gctgaggagg gagaatcgct 6292 tgaacccggg aggcggaggt tgcagtgagc ggagatcgcg ccactgcact ccagcctggt 6352 gacagagcaa gattctgtct caaaaaaaaa aaaaaaaaaa aaaaaaagtc ttgaactcct 6412 gggcgtg atc ctcccacctt ggcctcccaa agtgcaggga ttacaggtgc gaaccatcat 6472 gcccagcctg aataaccttt agatgtgacc accgttatcc tgttaaaatc tcgattcctt 6532 ttggaattag aacataagca ttgttttcag tctccagagt tctactgtgt catatactct 6592 acatgttcca tactattcac tgaaatcacc tggattttcc cctagttagt aagtatgtag 6652 atcacttttt tccatccata tcagcatgtc atgctgataa cactatcaat atagtgtcat 6712 tttaaaacag aggagtgggg gtgcagtgtt tcatcatgac tgtaatccca ggaatttggg 6772 aggccaaggt aggaggataa ctggaggcca ggaattcaag gccagcctgg gcaacaatgc 6832 aggaccccat cttgacaaaa cat 6855 <210> 154 <211> 6668 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (58) .. (543) <400> 154 aggagcagtg ggtcaaaggc gccctggagc cgaaagtgtc tgcggagttt gatctga 57 ctt tgg aca gcg agc cgc tgc tgc agg cca tcc acc agc tat gac gac 105 Leu Trp Thr Ala Ser Arg Cys Cys Arg Pro Ser Thrg Serp Asg Prog gtg ctg ggc aca gct gcg ttc tcc aag ggc gtg cac tac tgg 153 Arg Val Val Leu Gly Thr Ala Ala Phe Ser Lys Gly Val His Tyr Trp 20 25 30 gag ctg cac gtg gac cgg tac gac aac cac cca gc gcc gcc 201 Glu Leu His Val Asp Arg Tyr Asp Asn His Pro Asp Pro Ala Phe Gly 35 40 45 gtg gcc agg gcc agc gtg gtc aag gac atg atg ctg ggc aag gat gac 249 Val Ala Arg Ala Ser Val Val Lys Asp Met Met Leu Gly Lys Asp Asp 50 55 60 aag gcc tgg gcc atg tat gtg gac aac aac cgc agc tgg ttc atg cac 297 Lys Ala Trp Ala Met Tyr Val Asp Asn Asn Arg Ser Trp Phe Met His 65 70 75 80 tgc aac tcc cac acc aac agg acg gaa ggt ggc gtg tgc aag ggg gcc 345 Cys Asn Ser His Thr Asn Arg Thr Glu Gly Gly Val Cys Lys Gly Ala 85 90 95 acc gtg ggc gtg ctg ctg gac ctg aat aag cac act ctc acc ttc ttc 393 Thr Va l Gly Val Leu Leu Asp Leu Asn Lys His Thr Leu Thr Phe Phe 100 105 110 atc aac ggg cag cag cag ggc ccc aca gcc ttc agc cac gtg gac ggg 441 Ile Asn Gly Gln Gln Gln Gly Pro Thr Ala Phe Ser His Val Asp Gly 115 120 125 gtc ttc atg cca gcc ctc agc ctc aac cgc aac gtg cag gtc acc ctg 489 Val Phe Met Pro Ala Leu Ser Leu Asn Arg Asn Val Gln Val Thr Leu 130 135 140 cac aca gga ttg gaa gtg ccg act aac ggg cgg cca aag ctg tca 537 His Thr Gly Leu Glu Val Pro Thr Asn Leu Gly Arg Pro Lys Leu Ser 145 150 155 160 ggc aat tagccccgct ccagctcggc actgtgcctg tgacagtgac attcacaggc 593 Gly Asn aaaacgccca ccattctcac taagctcaaa taacccacaa aagcaggata tgcaaatcat 653 gggtgcaacc tggcagcgtg gagtgtcata gaaacacatt ttcttgggga cgcagggaat 713 gggtccacgg gccatgctca cagctgccac tgtcagtggc aaaggaaggt acgtgtgtca 773 cccttattcc acccagacat tacgaacact ccccaagaag gacctttctc aagggagtca 833 gcattcgggc ttcatgtcta tgtttcctgc catctgtttt caaagcttgt ctttttttgg 893 agggagagga aggtagactt tgagactggc ctcctgagag cggcagtcag gagctgcgct 95 3 gtaatcccac gccccgggtg ttggccctcc gtggggacct tgcctcctca gagtcccgag 1013 attgcagatt ctcatcatgc tgagaaagtt atcttttagc ttcttggtcc tagagtcttt 1073 agtagcacct gccacttgca gacccaatgc aggattgata gaaagggaca ttaatcattc 1133 atgcttgact tttgcctctc tcactgaagt gttagaacct tttaaaatgg cttcctttat 1193 taatcagcca attgtgttct ctctctctct tcctccatcc ttcatttctt ctccctccct 1253 ccttctcttt ctctcttctt ctctctctcc ttccttccct cctttgctct ctctttcttc 1313 ctttcctcct tctctcttac tttcctccat ccctgcctct ttcttccctc tttcgctctc 1373 tttccctccc tccttctctc tctctctcac acacacacag gcatgacagt ctcctaaaat 1433 taattcactc agttcttagt tcttaaatcc acgtgaaaac acaagaattt taacaactat 1493 gtcataggtc ttcgcctggt gatggctcct ttctgaaact ggcagcccaa gaagttaact 1553 gaaaatgcat ccagattgct cttctgagct gaaccactct cagactcata agcatttaaa 1613 atgggagacc ctgggaaagc ctgttctagt cagtccaccc tattgtcatt atgaaagcat 1673 catgaacaca agtggcccct gtggcaggcc gggacggctc tgccctgatg cagtgggcgg 1733 gatctctggg gaaggcagga aatagaaggg cagtatcagg taccttgtct cccagcttcc 1793 cact gtgaga ctgggtgtgc cgagtctgac ctgccagggc aggactctgg aaacaccagg 1853 cttctccctt gagatccaca ttgattcatc cacacctctc agagacagct catggcaggg 1913 gttttgagcc tgccaggctc ttgttcccag ggaacccttc ctctcctccc tcctctcatc 1973 ttcccagtca cctgccacct ccagctccac ctggtagtaa catttctctc tccttttaaa 2033 aagaatatat tttgtcaagc attttatttc tgaggctgag aagtgacttg tcaatttgct 2093 ggactggatt tttataaaat tcgcccattc accagcacca actgtgcgtc cttggttctg 2153 ccttcctgtt cagacaccgc gcctgctttc tgagtaactg cctgccggag ccatgcaggt 2213 accccccctc cactcagcag gcccgacaat cctacctcaa agctcatgct cttggtctgc 2273 aaggctgctt ggtccgctgt ctctgcagat gtggccggca aggccagctg ccccgtctcc 2333 aggagctgct cggtgctgtg ttgcagtctc tgctgcggag cctgggagct atctgcttca 2393 tggaagtcta ggtcttgcct cttccttgtc atctcaccaa gcggtttctg ggtctcctcc 2453 tcccatccca gagccctgtc cagagctctt ggtggtgaca cacaagacct gggaccctgt 2513 gtccttgccc gcacctctgc ctctgtctcc catatccctg cagcttcatc cttagccata 2573 gctctgggtg gcctttgctt ggagcatgga gacgatccct aaagattgag gatgaagagg 2633 agccaccac t ttcctggggc caaggaagcc atcagctttg ggaagtgtct agctctcttc 2693 tgaaaaaaaa acaggcctac accctgcccc cagaatgaga gtgggctagg cagggctgcc 2753 tggtgacagc agcttctcac aggggagccc tggggaaggc tgtggagcct ccaccatcac 2813 cacagcccag gtcaccaggt ggccccagct ctgcagaaga atcgcccatc attggagcac 2873 aagttgcctg gggctaccct gaacctaacc cctttgaggg agcagcatcc aggtcaggag 2933 agaagtggaa agtgcaggag ggtaatgccc tcaaatccgg tggcctcttt cagaaaaaag 2993 ttccctgaag tccagagagg tgcagccagg actccctcct ccccactgcc accctgagct 3053 tgggggctgg gattctccct tttctgactc ctccaggagc ccagaagcaa tacggccgat 3113 gccagggaca gcatccagct ctccttcaca gacacctctc ctgtcttcag cacaaaacac 3173 cttcaatgtt ctgacttcaa agagaacgac aggtccgtgc cacacacttg tgtttttgag 3233 ggatcagaaa agtgaagaag gaacttatca attcctcatg gccaggaagg tcccgggttt 3293 cagagtagaa atgacagaca ggtcatggaa ttctcatcca ccatcgaatt ccataacacg 3353 ttacatcatg gtggcacatt tgtacataca tataaatgat atcaagatga ggcttttgtt 3413 gggctggctg aggagtaact tggtgtaaat ctatcaagca gtttcagtga aaaaggaatt 3473 caaagtagtt taaa aatgtc gagttccatt gcattgtaaa tagtgcctct gtaatgtggt 3533 tctgcagttg ttctttgcta gtgagcaagc ttggtcaaag tgtatgcctt ttccttttaa 3593 aattaatctc ttccgaaaat atccactagc acctcactgc atacatagca tcccagctcc 3653 taattcaaag caggggaagg tatttcccca aagcctgctt ttcctctctc tgttctcctt 3713 gggaaaataa tgattccaat taaagaggac accagtaata ctgacccaca aggtaactga 3773 cctaaacact ataaaactgt atatatttcc aggctgcatc ttcagcctga tatgtacttt 3833 gtagttgcaa cagcgcccta ggtgccctat ggcccaccaa gtttgaggag ggtggtgctt 3893 tccggattga gcctgggcag gctctgtgga gctcaccaag agagctgggg gcaggcccac 3953 cctcctcttt gcgccctttc tctccctctt ggtgcccctg ccctccgccc caccacagca 4013 ctctcaggaa aggatcagaa tgcaggatct ttgtgtattt cttccaggga tatttgcatt 4073 taagccttaa ttctcattgc aagcgaaagg cttggtcccc ctgggaaggc gggtttcggc 4133 accggtgggc aggtggttca gtgtcaagga ggctgctgct ggtcccatgg ccacctgctg 4193 gctttgaggt agtgagggag ggtcaatcct tagggggagt caacatgtga atgctaaaga 4253 acactgctgc acagcccgtg gggtggcgcc agggtttctc aacctctact gacattttgc 4313 gataggttct gtatgccgt a ggatgtttag caacatccct ggtctctacc catcatctgc 4373 cagtagcaac ccccaagtta ggtgtgacaa ccaaaagtat ctgtcgacat tgctaggtat 4433 ctcctggggg cctccacaag ttgagaacca ccaggttatg ccagtggttt gtcatgcatg 4493 gatctgtaga gggactgtgg cgctccggct gctttgttcc atagaaagcc tgtatgtgac 4553 aaagctgcca gcctttatct tgatacccaa gcccaggatt ttccatgtgt cttcaggggg 4613 caggtagggg aaaatggggt gagccacctc caacagatgc caacctgttg ggtcttgaat 4673 tttcactcac tgaagatgcc ccctgcccgc tccccacttc ctagaaagca aaactcgtta 4733 cctttgtttt ccttggccac attttactgg aagcaacagg aacttcttaa tgggtttgtg 4793 gccctcaatt ggtttttaaa aaaatctaac agatcttatt ggcaaatatt caagatggtg 4853 atgctggaaa atttcaggac ttttcttttg caagtgagcc ggtagctgtg tttgttgacc 4913 acattctttg gcagttcctc ccagaagatc aaaggatcct gcagctttaa cctaatatct 4973 aggctgtaaa aatatgaggg caggtttcgg gcaggatgta ttgatcagac accaagttca 5033 gccctcggtt acttccctct tttaacctgg ctttaatagt gattcatggt atgagtgggg 5093 gccaatctct tatcctttct gtgcctcagt atccccacct gaaatgagac tagtcatact 5153 aacctacctc ctctgatgta ttg tgaggat tatacaataa catttttaaa gaaaaaaagt 5213 gcagtctttc atctctggca tctaagctaa tgattcccat tcagtgactc aaacctgtgg 5273 ggggcgttcc agtgttctct gaccagtgtc ttccatccaa gcctccttgt gaccagggca 5333 aggagctgcc tggcctccag tgggtaaaat agacctttaa gacaggtttc ctatgaccat 5393 agaaagtaac accccatatg tttccattcc cggcgaggcc tgtttgaatg gcgctctgtg 5453 tgagtgctat gaacaggcta cctgtcagca gtctcactgc gaggcctcaa ggcctctgtg 5513 agcagaagcc cctttaaacc aaggaaggac actaacccag gcctctgcct tctttgttac 5573 ctaagttctg gtatctaagg ggtctctcat ctcacagctt gcctcctttg tttcgagggg 5633 tctctgcagt gtgaatgggt ttgaaatcca gtgtggatag cacgaagaga tgcaactgag 5693 ccgaagtttt gaaggctggt tgggctagtg ggtcatcatg tcactttcag atgactgata 5753 accgctggga ctgctggggc ttcaccagca cgagctatgc aggttggggg aggccctggc 5813 tttttcaatg attgacgttg acatcagtca ggagctggga gttgagacct ccagggaagt 5873 ctcgtccgga tccatcgctc ttctctcaag gagcacagtc ctgggaaagg cctagggacc 5933 tgtgggccgg tgatgcgggc actgcagacc aggccaggcc ctcgggtaaa gctctgagga 5993 gaggccaaaa ccaggcttca ggttcggga a ggtgactgct tgcaactgca gtagcaggaa 6053 catgtcaggt gcttactggg tgagacccag ccggggaagc ctctccaact cctcctagcc 6113 ctggaaacca gacacccaga gccccaggct ttctcggcac ccagaagaag tggggagcgg 6173 gcaaagcaga aaacattcaa tgcatgatgt aggattgctg cgttggcact aagctgttgt 6233 attaagcatg agaggtgttt gtttaacgtt ggcaaaggga tttaacaaga aacaaaaagc 6293 ttcgcgtcct tgttttgacc gtcgacagaa gtccaatttt cttgcctttc tttatcccca 6353 tttctcctcc ctccccttcc cccatcacat ccactttcgg tcactcgttg ttggtatttg 6413 gtggcagctc ttggtcctat tgctgtggat gttccactga aaacacgggg ggtagcgggg 6473 agtggtaagg aaagcaactt ttttctaatt tttgtattgg tatccacaag cgtttgtatt 6533 ttttgaattg caaacactgt gttttctttctggt ctttggtt tagttgaact ttctgtatta 6593 ccttttgga tacctgatta cgatt gattacct gatt ccttttggaacc <210> 155 <211> 6077 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3399) .. (4967) <400> 155 gttctgtgtt gtggcggccc tggatccggc gtcagggcga ccgggcggac gaggtggagc 60 cagagtctgt caggcgggcg cgatgaaggc actgatctta gtggggggct atgggacgcg 120 gctacggccg ctgacgctga gcaccccgaa gccactggtg gacttctgca ataagcccat 180 cttgctgcac caagtggagg cgctagccgc ggcaggcgtg gaccacgtga tcctggccgt 240 gagctacatg tcgcaggtgc tggagaagga aatgaaggca caggagcaga ggctgggaat 300 ccgaatctcc atgtcccatg aagaggagcc tttggggaca gctgggcccc tggcgctggc 360 ccgtgaccta ctctctgaga ctgcagaccc tttcttcgtc ctcaacagtg acgtgatctg 420 cgatttcccc ttccaagcca tggtgcagtt ccaccggcac catggccagg agggctccat 480 cctggtgacc aaggtggagg aaccctccaa gtacggtgtg gtggtgtgtg aggctgacac 540 aggccgcatt caccggttcg tggagaagcc acaggtgttt gtgtccaata agatcaacgc 600 aggcatgtac atcctgagcc ctgcagtgct gcggcgcatc cagctgcagc ctacgtccat 660 tgagaaggag gtcttcccca ttatggccaa ggaggggcag ctatatgcca tggagttaca 720 gggcttctgg atggacattg ggcagcccaa ggacttcctc actggcatgt gcctcttcct 780 gcagtcactg aggcagaagc agcctgagcg gctgtgctca ggccctggca ttgtgggcaa 840 cgtgctggtg gacccaagtg cccgcatcgg ccagaactgc agcattggcc ccaatgtgag 900 cctgggacct ggcgtggtgg tcgaagatgg tgtgtgtatc cggcggtgca cggtgctgcg 960 ggatgcccgg atccgttccc attcctggct tgagtcctgc attgtgggct ggcgctgccg 1020 cgtgggtcag tgggtacgca tggagaacgt gacagtgctg ggtgaggacg tcatagttaa 1080 tgatgagctc tacctcaacg gagccagcgt gctgccccac aagtctattg gcgagtcagt 1140 gccagagcct cgtatcatca tgtgagggga tgcagtgggg ctggccgagc cccggttttc 1200 ccatcagcaa ggggagtgct ggcctgacac atcagaagac cctggacttg tcattatttg 1260 tctggggggc actgggtgaa gctgaagctg ttggacacct gccttctcat gtggacatca 1320 tctggcagga tccctgctgg gcacacccca caaaccccac tccctcaaga agggccaggg 1380 ccagggctgt atggaataat aatttaatgc tcactgtggc cctgactgaa agtcaagctc 1440 aggcacaatt agggccatgg ctgggctccc accaatgagg atacaggcag gcaaggaggt 1500 tggatgtggt ggtgtgggat acaggagaag ggcaaaggga gctcataaat agggcccagc 1560 ctggctctgg gttcaaaggt ggaggttcca ggatggcaca ggctgtgagg gctaggcagc 1620 tgaggaggta gtactcgtat tggctccctt ctcccagtcc tctacagaca cgatggtggt 1680 tttgcagaag aagcagt cct tgttgttcat caggtgctgg ttgatacagc ctctacaaca 1740 ggggagggga tgaggactgc cctgcatgta cctactgctc tccccaccac caagctgtgg 1800 ggcccactta cttgcaggac ttgtggccac agggctggaa cacagcagag atggggtggg 1860 catagcagat ggggcagagg tcctcctcac tggtgggctg cagggaggag agtgaagggt 1920 gggctggagt tggatgcctg gctatgtgga tgtccgttgt gcctgtgtag gagtgcacac 1980 atattcaagt ggcatggacc tgtgcaccgt gttcccactc accagggagg cagctgctgc 2040 ctgggcagat gcagaggtca ggtgcgccag catctgttcc acttgggcca gctcatcggc 2100 actgatataa tccgcatctg gggagtggta ggtagtgtca agtcagaggt agctgaggat 2160 gtgatgcctc ttgaatattc ccagcctagg actttgctgt tcttaaggct cctgacccga 2220 cccagcccca gatttccctg acctgcccca ccagcccact cacagctctg cagggagaag 2280 cgcttccggt caggggctgg cagagcagtg ccaggtgctg ggggctctgg ctgtcccagg 2340 agatagcata ttgagcgtag ctggaagcag ggatctgcca ggagcactga tgtggcttgc 2400 tctctcctag gtaggggagg gtgcaagggc agtcagaagg cttggggcct ggctaaaagt 2460 ctctcttggg attgccaatg aggagtgcca tggctcgtac atgatcaccc cccctgcatc 2520 ctttccgtct ccctgcttcc ca aaccccaa gtcctgtatt ctagtaaggt gccacacagc 2580 ctgttttttt tttttttttt cttgagacga gtctcgctct gttgcccagg ctggagtgcg 2640 atggcacgat ctcggctcac tgcaacctcc acctcccggg ttcaagtgat tctcctgctt 2700 tagcctcccg agtagctgga attgcagacg cccaccacca cgcccggcta attgttgttg 2760 tatttttagt agagacaggg tttcaccagg ttggccaggc tggtctcgaa ttcctgacct 2820 caggtgatcc acctgccttg gcttcccaaa gtgctgggat tacaggcgtg agccaccgcg 2880 cccggcctgg ggtaccactt taagaaggct caggcgaacc accttaagat agtgagagtc 2940 tgcctgcccc ataatattat cagtccttca aagtcacttc aaataaacac taacagcagc 3000 ttggagacat tcttccagac tccccctttt actccccgag gaaaaacgag cggcggagag 3060 ctgccagcca aaggctgacg gggactttgg ggttggcctt gctccccatc tggcggtcat 3120 gcggggccat tgggcacaaa gggatgtagc cgccccgcct cctcaaacgg gaaccaatag 3180 gagcccgggc cccgcccctg gggggagtat ttaggagccg atcaggaact cgcttggaga 3240 gggctagcga agccgaaggg agcgcggcta agagtgccgc accgcctcac aacctgggaa 3300 ccggagagta ggggccgtcg gctggcaaga acccgccgtg cctcctcggc aagggccatc 3360 cggtgccacc catgtcgcac tagagca gaa gagggtga gtc ctg gaa ctg caa cct 3416 Val Leu Glu Leu Gln Pro 15 gca cag agc tgc tct gta ctg tcc ctg gtg gtc gcc gcc atg acc tgg 3464 Ala Gln Ser Cys Ser Val Leu Ser Leu Val Val Ala Ala 10 15 20 ttg gtg ctg ctg ggg aca ctg ctc tgc atg ctg cgc gtt ggg tta ggc 3512 Leu Val Leu Leu Gly Thr Leu Leu Cys Met Leu Arg Val Gly Leu Gly 25 30 35 acc ccg gac tcc gag ggt ttc ccg ctc cac aac tgc ccc 3560 Thr Pro Asp Ser Glu Gly Phe Pro Pro Arg Ala Leu His Asn Cys Pro 40 45 50 tac aaa tgt atc tgc gct gcc gac ctg cta agc tgc act ggc cta ggg 3608 Tyr Lys Cys Ile Cys Ala Ala Asp Leu Leu Ser Cys Thr Gly Leu Gly 55 60 65 70 ctg cag gac gtg cca gcc gag tta cct gcc gct act gcg gac ctc gac 3656 Leu Gln Asp Val Pro Ala Glu Leu Pro Ala Ala Thr Ala Asp Leu Asp 75 80 85 ctg agc cac aac gcg ctc cag cgc ctg cgc ccc ggc tgg ttg gcg ccc 3704 Leu Ser His Asn Ala Leu Gln Arg Leu Arg Pro Gly Trp Leu Ala Pro 90 95 100 ctc ttc cag ctg cgc gcc ctg cac cta gac cac cta gac gac ag 3752 Leu Phe Gln Leu Arg Ala Leu His Leu Asp His Asn Glu Leu Asp Ala 105 110 115 ctg ggt cgc ggc gtc ttc gtc aac gcc agc ggc ctg agg ctg ctc gat 3800 Leu Gly Arg Gly Val Phe Val Asn Ala Ser Gly Leu Aru Asp 120 125 130 cta tca tct aac acg ttg cgg gcg ctt ggc cgc cac gac ctc gac ggg 3848 Leu Ser Ser Asn Thr Leu Arg Ala Leu Gly Arg His Asp Leu Asp Gly 135 140 145 150 ctg ggg gcg ctg gag aag ctg ctt ttc aat aac cgc ttg gtg cac 3896 Leu Gly Ala Leu Glu Lys Leu Leu Leu Phe Asn Asn Arg Leu Val His 155 160 165 ttg gac gag cat gcc ttc cac ggc ctg cgc gcg ctc agc cat ctc the Glu A Leu His Gly Leu Arg Ala Leu Ser His Leu Tyr 170 175 180 ctg ggc tgc aac gaa ctc gcc tcg ttc tcc ttc gac cac ctg cac ggt 3992 Leu Gly Cys Asn Glu Leu Ala Ser Phe Ser Phe Asp His Leu His Gly 185 190 195 agc gcc acc cac ctg ctt act ctg gac ctc tcc tcc aac cgg ctg 4040 Leu Ser Ala Thr His Leu Leu Thr Leu Asp Leu Ser Ser Asn Arg Leu 200 205 210 gga cac atc tcc gta cct gag ctg gcc gcg ctg ccg gcc tt c ctc aag 4088 Gly His Ile Ser Val Pro Glu Leu Ala Ala Leu Pro Ala Phe Leu Lys 215 220 225 230 aac ggc ctc tac ttg cac aac aac cct ttg cct tgc gac tgc cgc ctc 4136 Asn Gly Leu Tyr Leu His Asn Leu Pro Cys Asp Cys Arg Leu 235 240 245 tac cac ctg cta cag cgc tgg cac cag cgg ggc ctg agc gcc gtg cgc 4184 Tyr His Leu Leu Gln Arg Trp His Gln Arg Gly Leu Ser Ala Val Arg 250 255 260 gac ttt gg gag tac gta tgc ttg gcc ttc aag gta ccc gcg tcc 4232 Asp Phe Ala Arg Glu Tyr Val Cys Leu Ala Phe Lys Val Pro Ala Ser 265 270 275 cgc gtg cgc ttc ttc cag cac agc cgc gtc tcgc gc tc gc gc tc gc gc tc gc gc tc gc tc gc gc tc gc gc tc gc gc Val Arg Phe Phe Gln His Ser Arg Val Phe Glu Asn Cys Ser Ser 280 285 290 gcc cca gct ctt ggc cta gag cgg ccg gaa gag cac ctg tac gcg ctg 4328 Ala Pro Ala Leu Gly Leu Glu Arg Pro Glu Glu His Leu Tyr Ala Leu 295 300 305 310 gtg ggt cgg tcc ctg agg ctt tac tgc aac acc agc gtc ccg gcc atg 4376 Val Gly Arg Ser Leu Arg Leu Tyr Cys Asn Thr Ser Val Pro Ala Met 315 320 325 cgc att gcc tgg gtt tcg ccg c ag cag gag ctt ctc agg gcg cca gga 4424 Arg Ile Ala Trp Val Ser Pro Gln Gln Glu Leu Leu Arg Ala Pro Gly 330 335 340 tcc cgc gat ggc agc atc gcg gtg ctg gcc gac ggc agc ttg gcc ata 472 Ser Ile Ala Val Leu Ala Asp Gly Ser Leu Ala Ile 345 350 355 ggc aac gta cag gag cag cat gcg gga ctc ttc gtg tgc ctg gcc act 4520 Gly Asn Val Gln Glu Gln His Ala Gly Leu Phe Val Cys Leu Ala Thr 360 365 370 ggg ccc cgc ctg cac cac aac cag acg cac gag tac aac gtg agc gtg 4568 Gly Pro Arg Leu His His Asn Gln Thr His Glu Tyr Asn Val Ser Val 375 380 385 390 390 cac ttt ccg cgc cca gag ccc gag gct ttcac ggc ttc acc aca 4616 His Phe Pro Arg Pro Glu Pro Glu Ala Phe Asn Thr Gly Phe Thr Thr 395 400 405 ctg ctg ggc tgt gcc gtg ggc ctt gtg ctc gtg ctg ctc tac ctg ttc 4664 Leu Leu Gly Cys Val Leu Val Leu Leu Tyr Leu Phe 410 415 420 gcc cca ccc tgc cgc tgc tgc cgc cgt gcc tgc cgc tgc cgc cgc tgg 4712 Ala Pro Pro Cys Arg Cys Cys Arg Arg Ala Cys Arg Cys Arg Arg Trp 430 430 430 430 430 430 430 a ccc agc ccg ctc caa gag ctg agc gca cag tcc tca gta 4760 Pro Gln Thr Pro Ser Pro Leu Gln Glu Leu Ser Ala Gln Ser Ser Val 440 445 450 ctc agc acc aca ccg cca gac gca ccc agc cgc aag gcc cgcgt 4808 Leu Ser Thr Thr Pro Pro Asp Ala Pro Ser Arg Lys Ala Ser Val His 455 460 465 470 aag cac gta gtc ttt ctg gag cca ggc cgg agg ggc ctc aat ggc cgc 4856 Lys His Val Val Phe Leu Glu Pro Gly Arg Arg Gly Leu Asn Gly Arg 475 480 485 gtg cag ctg gca gta gct gag gaa ttc gat ctc tac aac cct gga ggc 4904 Val Gln Leu Ala Val Ala Glu Glu Phe Asp Leu Tyr Asn Pro Gly Gly 490 495 500 ctg gct gag tg gag tcc gcc agc tcc ata ggc tcc gag 4952 Leu Gln Leu Lys Ala Gly Ser Glu Ser Ala Ser Ser Ile Gly Ser Glu 505 510 515 ggt ccc atg aca acc tagactgccc agggctcccc cacccaggcc cccaccctct 5007 Gly Pro Met Thrgcg cct gct cg cct cct gct cct cct gct Prog tgggaagcac 5067 tgtgcctggc cccccagctt cctgtatggg cctcgaaaca caatgggcct tctcgctcac 5127 tggtagagac aggggttgtg gtccccaacc tgccttctgc t ctgcccctg cacaggaccc 5187 aaaggcccca ggccctgcaa ggtgtgctag ttcctgcttt cccgcggact tcctagtgcc 5247 caaatgccct gtgaggctga gagacccagg cccctgtggc tttcaacaca gcacagctgt 5307 ggaagtggct gtgttcttct acagcctgtg gaagaacccc tgtagcagag cctcccgtcc 5367 accctcaggg gctgaggcag ctctcgagga gtggtgctca agagctgacg cagggccacc 5427 tccccttccc aagggggtgg gagggagtgg gcccacaggg aaaagaaggc ggctctgaag 5487 gaagatctcg cccacacccc aggacagaaa gaggaaacaa gcccgccctc tggtgaaatg 5547 ggactccctc catccaccaa cacccaacct cctgaaagct tcacaacttc acgcagagtc 5607 cggtgggcag gcaccaggca ggaaaggctc ctcaagaggt tcctggtggt ctggcctaag 5667 ccccagccag aggccctgct ctctctggcc tggggcatcc acccgttgtt ctgaaggcag 5727 agcccattct gtgggctcac aagacacagt gaaggggatc atggcctgca cccctgcttt 5787 tcagcagtaa aaagcccgaa aagcctggcg agcatggccg agctgggagg gccgagccgg 5847 aactccacgt ccctcgagag caggagcctc ttaagggctg gcactggtct cagcctaatg 5907 gctgaggcgg taccctggct tcatatgcat ctcactgctc ccactgcagg ggggcaggga 5967 aggggggtct gggagccctt catgtgtggg ggccgagctg ggggccc cca tggccatcct 6027 ggacctcgct gctccagagt ttaataaagg tagcacatgc ttattgctag 6077 <210> 156 <211> 5781 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1546) .. (5538) <400> 156 cttgtagaga cgcaggagtc tcaaaggcag tggaagacag aggccccagg gtgggcccgc 60 ctgtagcccc acttccccca cgtcaggagg aaagggaaga gggagagtcc cccagtctct 120 ctcagttggc agaggctctg caccccttta cagaggatcc tgccgcctca ggacagccag 180 gagggggctg gagggagagg aggtggcccc tgccctcagt ccctggacgg gcactattca 240 tggccccctg ttctgtccca caatccagtg tgtccttgtg accgtgccct ccctgaggct 300 ggtggtgatg gtggcctgtg tgtgcatcca agctcctgtg tgtgtgtttc aaggggcaca 360 aagctgcatg aagcttccta agagagtgct gagggagcac ttcctatagg aggaaggctg 420 gaaggcttcc tggaggcagc agcctggagc cctgtgcatg aggatgcggg actctgatag 480 ccaacctgct atttagtagg gaaagtcgcc ttccaagcca caggatggcc gtgacaagag 540 gcccaaaggc tcgcaggagt gctgcagcag agggcagggg tgtgggcagc tagagggacc 600 tgtggctggg cagggctgag gtagcccgtg tgctgtgccg gatcctttag acttgaccct 660 gttggctaca cagcatcagc cctgggtatt actcatccct gcgccctggc cagaatgaag 720 gaagcctctg gggtgggggg agggcacagc cccatgtgcc cacctcactg ccacatgccc 780 ccaggccctg cgggtgaatg gcctggagca actgtgcaac aacctcgcca gcgagcgcct 840 acagctcttc tccagccaga tgctgctggc ccaggaggag gaggagtgtc ggcgggagtt 900 gctgtcctgg gtgcctgtcc ctcagcctcc gagggagtcc tgcctagacc tcctggtaga 960 tcagccccac agcctcctga gtatcctgga cgcccagaca tggctgtccc aggccacgga 1020 ccacaccttc ctccagaaga gccactatca ccatggtgac caccccagct atgccaagcc 1080 ccggctgccc ctgcccgtgt tcaccgtgcg acattatgca gggactgtca cctaccaggt 1140 tcacaagttt ttaaacagaa accgggatca gctggaccct gctgtggtgg agatgcttgg 1200 ccagagccag ctccagctgg tgggcagcct gttccaggag gcagagcccc agtccagggg 1260 agggcgaggc agacccacgc tggcctctcg cttccagcag gccctggagg acctcatagc 1320 ccggctgggc aggagccatg tctatttcat ccagtgcctc acccctaacc ctggaaagct 1380 tccaggcctc tttgacgtgg gacatgtgac agagcaactg caccaggcag ccatactgga 1440 ggccgtgggc acccgcagtg ccaacttccc cgtgcgtgtg ccctttgagg ccttcctggc 1500 cagcttccag gccctggggt cagaagggca ggaagacctc tctga ccg gga gaa gtg 1557 Pro Gly Glu Val 1 tgg tgc cgt cct gag cca ggt gct ggg ggc cga atc acc tct cta tca 1605 Trp Cys Arg Pro Glu Pro Gly Ala Gly Gly Arg Ile Thr Ser Leu Ser 5 10 15 2 0 cct tgg agc cac caa ggt cct gct gca gga gca ggg ctg gca gcg gct 1653 Pro Trp Ser His Gln Gly Pro Ala Ala Gly Ala Gly Leu Ala Ala Ala 25 30 35 gga gga gct ccg gga cca gca gcg ctc cca ggc cct cga cct gca 1701 Gly Gly Ala Pro Gly Pro Ala Ala Leu Pro Gly Pro Gly Arg Pro Ala 40 45 50 ccg cag ctt cca cac ctg cat ctc ccg cca gcg cgt cct gcc ccg gat 1749 Pro Gln Leu Pro His Leu His Leu Pro Pro Ala Arg Pro Ala Pro Asp 55 60 65 gca ggc tcg cat gcg tgg gtt cca ggc cag cct gtc ttc aca cat tcc 1797 Ala Gly Ser His Ala Trp Val Pro Gly Gln Pro Val Phe Thr His Ser 70 75 80 tcc aac agc tgt tgg ctg acc gtc tgc ctc atc tac cct tgg gcc aga 1845 Ser Asn Ser Cys Trp Leu Thr Val Cys Leu Ile Tyr Pro Trp Ala Arg 85 90 95 100 tgc tgg cga cag agc tgg gga tgc cag aga cgg ggc ctc cca ggc tgg 18 Trp Arg Gln Ser Trp Gly Cys Gln Arg Arg Gly Leu Pro Gly Trp 105 110 115 ttg gga agt cag att cag atg gta gag cag cca gtg atc ttc ttc cca gag 1941 Leu Gly Ser Gln Ile Gln Met Val Glu Gln Pro Val Ile Phe Pro Glu 120 12 5 130 agt aac tcg agg gct gag aat gaa gtg aag aca gtg cag aac atc ggg 1989 Ser Asn Ser Arg Ala Glu Asn Glu Val Lys Thr Val Gln Asn Ile Gly 135 140 145 gga gcc agg cat ctc cac tat cta ttt cca aca cgt ttt cat ccc gca 2037 Gly Ala Arg His Leu His Tyr Leu Phe Pro Thr Arg Phe His Pro Ala 150 155 160 aac aga aac tct gga ccc att aag cag aag cgg tac ctc cgg cgg cgg 2085 Asn Arg Asn Ser Gly Pro Ile Lys Gln Lys Arg Tyr Leu Arg Arg Arg 165 170 175 180 gca gct ttg gga cag ctg aac acc atc ctg ctg gtg gcc cag ccc ctg 2133 Ala Ala Leu Gly Gln Leu Asn Thrle Ile Leu Leu Val Ala Gln Pro Leu 185 190 agg ctc cgg cag aga ctg cag ctt ggg cgt tgg cag ggc tgg cat 2181 Leu Gln Arg Arg Gln Arg Leu Gln Leu Gly Arg Trp Gln Gly Trp His 200 205 210 agc agc gaa agg gcc ttg gag aga gtg cca agc atg gagc 2g Ser Ser Glu Arg Ala Leu Glu Arg Val Pro Ser Met Glu Leu Gly Arg 215 220 225 ttg gag atc ccg gct gag ctg gcc gtc atg ctg aag acg gcg gaa agc 2277 Leu Glu Ile Pro Ala Glu Leu Ala Val Met Leu Lys Thr Ala Glu Ser 230 235 240 cat cgg gac gcc ctg gct ggg agc atc acc gag tgc ctg ccg cct gag 2325 His Arg Asp Ala Leu Ala Gly Ser Ile Thr Glu Cys Leu Pro Pro Glu 245 250 255 260 gtt cct gcc cgg ccc agc ctg act ctc cca gca gac att gac ctg ttc 2373 Val Pro Ala Arg Pro Ser Leu Thr Leu Pro Ala Asp Ile Asp Leu Phe 265 270 275 cct ttc tcc agc ttc gtc gcc atc ggc ttt cag gaa ccg tcc ctg ccc 2421 Pro Phe Val Ala Ile Gly Phe Gln Glu Pro Ser Leu Pro 280 285 290 agg cca ggg cag cca ctg gcg aag ccc cta acc cag ctg gat gga gac 2469 Arg Pro Gly Gln Pro Leu Ala Lys Pro Leu Thr Gln Leu Asp Gly Asp 295 300 305 aac cct cag cgt gcc ctg gac atc aac aaa gtg atg ctg cgg ctc ctg 2517 Asn Pro Gln Arg Ala Leu Asp Ile Asn Lys Val Met Leu Arg Leu Leu 310 315 320 ggg gac gga tcc ctg gag tcc tgg atg ag cag ggc gca tac 2565 Gly Asp Gly Ser Leu Glu Ser Trp Gln Arg Gln Ile Met Gly Ala Tyr 325 330 335 340 ctg gtg cgg cag ggg cag tgc tgg cca ggg ctg cgg aat gag ctc ttt 2613 Leu Val Arg Gln Gly Gln Cy Trp Pro Gly Leu Arg Asn Glu Leu Phe 345 350 355 agc cag ctg gtg gcc cag cta tgg cag aac cca gat gaa cag cag agc 2661 Ser Gln Leu Val Ala Gln Leu Trp Gln Asn Pro Asp Glu Gln Gln Ser 360 365 370 cag cgt ggc tgg gcc ctc atg gct gtt ttg ctc agc gcc ttt ccc cca 2709 Gln Arg Gly Trp Ala Leu Met Ala Val Leu Leu Ser Ala Phe Pro Pro 375 380 385 ctg cct gtc cta cag aag cca ctg ctc gc gc gc 2757 Leu Pro Val Leu Gln Lys Pro Leu Leu Lys Phe Val Ser Asp Gln Ala 390 395 400 ccc agg ggc atg gca gcg ctg tgc cag cac aag ctg ctg ggg gcc ttg 2805 Pro Arg Gly Met Ala Ala Leu Cys Gln His Lysu Gly Ala Leu 405 410 415 420 gag cag tcg cag ctg gcc tcg ggg gcc act cgg gcc cac ccc ccg acc 2853 Glu Gln Ser Gln Leu Ala Ser Gly Ala Thr Arg Ala His Pro Pro Thr 425 430 435 cag ctg gag tgg ctg gcc gga tgg cgg cgg ggc cgc atg gcg ctg gat 2901 Gln Leu Glu Trp Leu Ala Gly Trp Arg Arg Gly Arg Met Ala Leu Asp 440 445 450 gtg ttc acc ttc agc gag gag tgc tac tcg gcc gag gtg gag the Thr Phe Ser Glu Glu Cys Tyr Ser Ala Glu Val Glu Ser Trp 455 460 465 acc acc ggg gag cag ctg gct ggg tgg atc ctg cag agc aga ggc ctg 2997 Thr Thr Gly Glu Gln Leu Ala Gly Trp Ile Leu Gln Ser Arg Gly Leu 470 475 480 gag gcg cct ccc cgg ggc tgg tct gtg tca ctg cac tcc agg gac gca 3045 Glu Ala Pro Pro Arg Gly Trp Ser Val Ser Leu His Ser Arg Asp Ala 485 490 495 500 tgg cag gac ttg gct ggc tgc gac tt ctg gac ctg atc agc cag 3093 Trp Gln Asp Leu Ala Gly Cys Asp Phe Val Leu Asp Leu Ile Ser Gln 505 510 515 act gag gac ctg ggg gac cca gct cgc ccc cgc agc tac ccc atc act 3141 Thr Glu Asp Leu Gly Ala Arg Pro Arg Ser Tyr Pro Ile Thr 520 525 530 cct ctt ggc tca gcc gag gcc att ccc ctt gcc cct ggc att cag gcc 3189 Pro Leu Gly Ser Ala Glu Ala Ile Pro Leu Ala Pro Gly Ile Gln Ala 535 540 540 ccc tca ctg ccc cca gga ccc cct cca ggt cca gcc cca acg ctg ccc 3237 Pro Ser Leu Pro Pro Gly Pro Pro Gly Pro Ala Pro Thr Leu Pro 550 555 560 agc agg gac cac aca ggg gag gtc cag agg tca ggg agc ctg gac ggc 3285 Ser Arg Asp His Thr Gly Glu Val Gln Arg Ser Gly Ser Leu Asp Gly 565 570 575 580 ttc ctg gac cag atc ttc cag cca gtg ata tcc tcc ggc ctc agc gat 3333 Phe Leu Asp Gln Ile Ple Gln Pro Val Ser Ser Gly Leu Ser Asp 585 590 595 ctg gaa caa agc tgg gct ctg agc agc cgc atg aag gga ggg ggc gcc 3381 Leu Glu Gln Ser Trp Ala Leu Ser Ser Arg Met Lys Gly Gly Gly Ala 600 605 610 att gg ccc cag ggc tac ccc atg gtg tac cca gga atg att 3429 Ile Gly Pro Thr Gln Gln Gly Tyr Pro Met Val Tyr Pro Gly Met Ile 615 620 625 cag atg cct gca tac cag cca ggc atg gtc cct gca ccc atg ccc atg 3477 Gln Pro Ala Tyr Gln Pro Gly Met Val Pro Ala Pro Met Pro Met 630 635 640 atg cca gca atg ggc aca gtc cct gcc atg cca gcc atg gtg gtg ccg 3525 Met Pro Ala Met Gly Thr Val Pro Ala Met Pro Ala Met Val Val Pro 645 650 655 660 ccg cag cca ccg ctt ccc agc ctg gat gca ggg cag ctg gcc gtc cag 3573 Pro Gln Pro Pro Leu Pro Ser Leu Asp Ala Gly Gln Leu Ala Val Gln 665 670 675 cag cag aac ttt atc cag cag cag cg cta atc ctg gcc cag cag atg 3621 Gln Gln Asn Phe Ile Gln Gln Gln Ala Leu Ile Leu Ala Gln Gln Met 680 685 690 aca gcc cag gcc atg tcc ctg tcc ctg gag cag cag atg cag cag cgg 3669 Thr Ala Gln Ser Leu Ser Leu Glu Gln Gln Met Gln Gln Arg 695 700 705 cag cag cag gct cgg gcc tcc gag gct gcg tcc cag gcc tca ccc tca 3717 Gln Gln Gln Ala Arg Ala Ser Glu Ala Ala Ser Gln Ala Ser Pro Ser 710 715 715 720 gcc gtc acc tcc aag ccc agg aag ccc ccc aca ccc ccg gag aag cca 3765 Ala Val Thr Ser Lys Pro Arg Lys Pro Pro Thr Pro Pro Glu Lys Pro 725 730 735 735 740 cag cgt gac ctg gga tca gag ggt ggc tgc ctg agg gag acc tcc gag 3813 Gln Arg Asp Leu Gly Ser Glu Gly Gly Cys Leu Arg Glu Thr Ser Glu 745 750 755 gag gct gaa gac agg ccc tat cag ccc aag agc ttc cag cag aaa cgg 3861 Glu Ala Glu Asp Arg Pro Tyr Gln Pro Lys Ser Phe Gln Gln Lys Arg 760 765 770 aac tat ttc cag agg atg ggg cag cca cag atc aca gtg agg acg atg 3909 Asn Tyr Phe Gln Arg Met Gly Gln Pro Gln Ile Thr Val Arg Thr Met 775 780 785 785 aag ccc ccg gcc aag gtc cac atc ccc cag ggg gaa gcg cag gag gag 3957 Lys Pro Pro Ala Lys Val His Ile Pro Gln Gly Glu Ala Gln Glu Glu 790 795 800 gag gag gag gag gag gag gag gag gag cag gag gag caa gaa gtgga Glu Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu Gln Glu Val Glu 805 810 815 820 aca aga gca gtg ccg tcc cct cct cct ccc ccc atc gtg aag aag cca 4053 Thr Arg Ala Val Pro Ser Pro Pro Pro Pro Pro Pro Ile Val Lys Lys Pro 825 830 835 ttg aag caa ggt ggg gcc aaa gct cca aaa gag gct gag gct gag cca 4101 Leu Lys Gln Gly Gly Ala Lys Ala Pro Lys Glu Ala Glu Ala Glu Pro 840 845 850 gcc aag gag aca gcg gcc ag cat ggc caa ggg cca gcc caa ggc 4149 Ala Lys Glu Thr Ala Ala Lys Gly His Gly Gln Gly Pro Ala Gln Gly 855 860 865 agg ggg act gtg gtg cgc agc tca gac tcc aag ccc aag cgg cca caa 4197 Arg Gly Val Arg Ser Ser Asp Ser Lys Pro Lys Arg Pro Gln 870 875 880 ccc agc agg gaa att ggc aac atc atc cgc atg tac cag agc cgc ccg 4245 Pro Ser Arg Glu Ile Gly Asn Ile Ile Arg Met Tyr Gln Ser Arg Pro 885 8 90 895 900 ggc ccc gtg cct gtg ccc gtg cag cca tcc agg cct ccc aaa gct ttc 4293 Gly Pro Val Pro Val Pro Val Gln Pro Ser Arg Pro Pro Lys Ala Phe 905 910 915 ctg agg aaa atc gac ccc aag gac gag gct ctg gcc aag ctg ggt atc 4341 Leu Arg Lys Ile Asp Pro Lys Asp Glu Ala Leu Ala Lys Leu Gly Ile 920 925 930 aac ggt gcc cac tcg tcc ccg ccg atg ctg tcc ccc agc cca gga aag 4389 Asn Gly Ala His Ser Met Leu Ser Pro Ser Pro Gly Lys 935 940 945 ggc ccc ccg cca gct gtg gct cct cga ccc aag gcc ccg cta cag ctt 4437 Gly Pro Pro Pro Ala Val Ala Pro Arg Pro Lys Ala Pro Leu Gln Leu 950 955 960 ggg ccc tct agc tcc atc aag gaa aag cag ggg ccc ctt ctg gac ctg 4485 Gly Pro Ser Ser Ser Ile Lys Glu Lys Gln Gly Pro Leu Leu Asp Leu 965 970 975 980 ttt ggc cag aag ctg cct att gcc cac aca ccc cca cg cca 4533 Phe Gly Gln Lys Leu Pro Ile Ala His Thr Pro Pro Pro Pro Pro Ala 985 990 995 cca cca ctg cct ctg ccc gag gac cca ggg acc ctt tca gca gag cgt 4581 Pro Pro Leu Pro Leu Pro Glu Asp Pro Gly Thr L eu Ser Ala Glu Arg 1000 1005 1010 cgt tgc ttg aca cag ccc gtg gag gac cag ggg gtc tcc acc cag cta 4629 Arg Cys Leu Thr Gln Pro Val Glu Asp Gln Gly Val Ser Thr Gln Leu 1015 1020 1025 ctc gcg ccc tct ggc ag gtg tgc ttc tcc tac acc ggc acg ccc tgg 4677 Leu Ala Pro Ser Gly Ser Val Cys Phe Ser Tyr Thr Gly Thr Pro Trp 1030 1035 1040 aag ttg ttc cta cgc aag gag gtg ttc tac cca cgg gag aac ttc agc P725 Lyc Leu Arg Lys Glu Val Phe Tyr Pro Arg Glu Asn Phe Ser 1045 1050 1055 1060 cat ccc tac tac ctg agg ctc ctc tgt gag cag atc cta cgg gac acc 4773 His Pro Tyr Tyr Leu Arg Leu Leu Cys Glu Gln Ile Leu Arg Asp Thr 1065 1070 1075 ttc tcc gag tcc tgt atc cgg att tcc cag aat gag cgg cgg aaa atg 4821 Phe Ser Glu Ser Cys Ile Arg Ile Ser Gln Asn Glu Arg Arg Lys Met 1080 1085 1090 aaa gac ctg ctg gga ggc ttg gag ggt gat tct ctc acc acc 4869 Lys Asp Leu Leu Gly Gly Leu Glu Val Asp Leu Asp Ser Leu Thr Thr 1095 1100 1105 acc gaa gac agc gtc aag aag cgc atc gtg gtg gcc gct cgg gac aac 4917 Thr Glu Asp Ser Val Lys Lys Arg Ile Val Val Ala Ala Arg Asp Asn 1110 1115 1120 tgg gcc aat tac ttc tcc cgc ttc ttt cct gtc tcg ggc gag agt ggc 4965 Trp Ala Asn Tyr Phe Ser Arg Phe Phe Pro Val Ser Gly Glu Gly 1125 1130 1135 1140 agc gac gtg cag ctg tta gcc gtg tcc cac cgt ggg ctg cga ctg ctc 5013 Ser Asp Val Gln Leu Leu Ala Val Ser His Arg Gly Leu Arg Leu Leu 1145 1150 1155 aag gtg acc cag ccc ccc ccc gac cag ctg aag att ctc 5061 Lys Val Thr Gln Gly Pro Gly Leu Arg Pro Asp Gln Leu Lys Ile Leu 1160 1165 1170 tgc tca tac agc ttt gcg gag gtg ctg ggt gtg gag tgc cgg ggc Tgg Ser Acer Ser Glu Val Leu Gly Val Glu Cys Arg Gly Gly 1175 1180 1185 tcc acc ctg gag ctg tca ctg aag agc gag cag ctg gtg ctg cac aca 5157 Ser Thr Leu Glu Leu Ser Leu Lys Ser Glu Gln Leu Val Leu His Thr 1190 1195 1200 gcc cgg gca agg gcc atc gag gcg ctg gtt gag cta ttc ctg aat gag 5205 Ala Arg Ala Arg Ala Ile Glu Ala Leu Val Glu Leu Phe Leu Asn Glu 1205 1210 1215 1220 ctt aag aag gac tcc ggc tat gtc atc gcc ctg cgc agc tac atc act 5253 Leu Lys Lys Asp Ser Gly Tyr Val Ile Ala Leu Arg Ser Tyr Ile Thr 1225 1230 1235 1235 gac aac tgc agc ctc ctc agc ttc cac cgt ggg gac ctc atc Asag Asg ctc Leu Leu Ser Phe His Arg Gly Asp Leu Ile Lys Leu 1240 1245 1250 ctg ccg gtg gcc acc ctg gag cca ggc tgg cag ttt ggc tct gcc ggg 5349 Leu Pro Val Ala Thr Leu Glu Pro Gly Trp Gln Phe Gly Ser Ala Gly 1255 1265 ggc cgt tcc gga ctc ttt cct gcc gac ata gtg cag ccg gct gcc gct 5397 Gly Arg Ser Gly Leu Phe Pro Ala Asp Ile Val Gln Pro Ala Ala Ala 1270 1275 1280 ccc gac ttt tcc ttc tcc aag gag gag agg agt cac aag ggt 5445 Pro Asp Phe Ser Phe Ser Lys Glu Gln Arg Ser Gly Trp His Lys Gly 1285 1290 1295 1300 cag ctg tcc aac ggg gaa cca ggg ctg gct cgg tgg gac agg gcc tca 5493 Gln Leu Ser Asn Gly Glu Pro Gly Leu Ala Arg Trp Asp Arg Ala Ser 1305 1310 1315 gag gtg agg aag atg gga gag gga caa gca gag gca agg cct gcc 5538 Glu Val Arg Lys Met Gly Glu Gly Gln Ala Glu Ala Arg Pro Ala 1320 132 5 1330 tgagactgag gaaggaaagg ggtttgacca ctcccgaggc tgccatgcgg tgggaccacc 5598 ctgctgtccg tctcctgtgg ctgcccctct gcccgctcct gatggctcgc cttgtctctc 5658 cagcaagact gtgcactcct tgcaggcagg ggctgggctg gatgctgctc ttgtgtccca 5718 cgtggtactt agttcaaggc tgccccagca gatgcttaat aaacagctct tcactttcct 5778 ggc 5781 <210> 157 <211> 6123 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1092) <400> 157 cga ctg gct ggt ccc ctg gcc gtg agc cgg ctt ctg aat gat tta tgc 48 Arg Leu Ala Gly Pro Leu Ala Val Ser Arg Leu Leu Asn Asp Leu Cys 1 5 10 15 cgc ctt gaa ctt gac tcc agc gtg gga gtg aga aga gcc gct ccc 96 Arg Leu Glu Leu Asp Ser Ser Val Thr Gly Val Arg Arg Ala Ala Pro 20 25 30 gct aga gga aag ctg gaa acc gta ctg tgc tca cca cat aac ctc tgg 144 Ala Arg Gly Lys Leu Glu Thr Val Leu Cys Ser Pro His Asn Leu Trp 35 40 45 gtg ctg gaa atg gag tat tac tac tgc ccc agc ctg ctg aag ctc ttg 192 Val Leu Glu Met Glu Tyr Tyr Tyr Cys Pro Ser Leu Leu Lys Leu Leu 50 55 60 cgc tac ctc tgg gac cag ctg aag cag tgt ttc tcc cgg cag ccc act 240 Arg Tyr Leu Trp Asp Gln Leu Lys Gln Cys Phe Ser Arg Gln Pro Thr 65 70 75 80 gaa ccc aag gac act gac acc ctc gtg cac gaa gcc ggc ag cag tat 288 Glu Pro Lys Asp Thr Asp Thr Leu Val His Glu Ala Gly Ser Gln Tyr 85 90 95 ggg acg tgg aca gag cag tgc cag agt ggg gag agc ttg gcc act gag 336 Gly Thr Trp Thr Glu Gln Cys Gln Ser Gly Glu Ser Leu Ala Thr Glu 100 105 11 0 tcc cca gat agc agt gcc aca tcg aca agg aaa cag ccc ccc agc agc 384 Ser Pro Asp Ser Ser Ala Thr Ser Thr Arg Lys Gln Pro Pro Ser Ser 115 120 125 cgt ttg tct tct ctg tcc tcc caa acg gag ccc acc tcg gca ggg gac 432 Arg Leu Ser Ser Leu Ser Ser Gln Thr Glu Pro Thr Ser Ala Gly Asp 130 135 140 cag tat gac tgc tcc agg gac cag cgg agc acc agc gtg gac cac tcc 480 Gln Tyr Asp Cys Ser Arg Asp Gln Arg Ser Thr Ser Val Asp His Ser 145 150 155 160 agc act gac ctg gaa tcc acc gat ggg atg gag ggg ccg cct cca ccg 528 Ser Thr Asp Leu Glu Ser Thr Asp Gly Met Glu Gly Pro Pro Pro Pro 165 170 175 gac gcc tgc cct gaa aag aga gta gat gac ttc tcc ttc att gat caa 576 Asp Ala Cys Pro Glu Lys Arg Val Asp Asp Phe Ser Phe Ile Asp Gln 180 185 190 acc tca gtc ctc gac tca agt gcc ctc aag acc cgg gtg cag ctc ag Ser Val Leu Asp Ser Ser Ala Leu Lys Thr Arg Val Gln Leu Ser 195 200 205 aag aga agc cgc cgc cgg gcc ccc atc tcc cac tcc ctc cgg cgc agc 672 Lys Arg Ser Arg Arg Arg Ala Pro Ile Ser His Ser Leu Arg Arg S er 210 215 220 cga ttt agt gag tcc gag agc aga tca cct ttg gag gat gag act gac 720 Arg Phe Ser Glu Ser Glu Ser Arg Ser Pro Leu Glu Asp Glu Thr Asp 225 230 235 240 aac acg tgg atg ttc aaa gac tca acg gag gag aaa tca ccc agg aag 768 Asn Thr Trp Met Phe Lys Asp Ser Thr Glu Glu Lys Ser Pro Arg Lys 245 250 255 gaa gag tcg gat gag gag gag acg gca tcc aaa gct gag agg acc ccc 816 Glu Glu Ser Asp Glu Glu Glu Thr Ala Ser Lys Ala Glu Arg Thr Pro 260 265 270 gtc agc cat cct cag agg atg cct gcg ttt cca ggc atg gat ccg gca 864 Val Ser His Pro Gln Arg Met Pro Ala Phe Pro Gly Met Asp Pro Ala 275 280 285 285 gtg cta aag gct cag ctg cac aag agg cca gag gtg gac agt cct ggc 912 Val Leu Lys Ala Gln Leu His Lys Arg Pro Glu Val Asp Ser Pro Gly 290 295 300 300 gag acc ccc agc tgg gca ccc caa ccc aag agc ccc aag tcc ccc ttc 960 Glu Thr Pro Ser Trp Ala Pro Gln Pro Lys Ser Pro Lys Ser Pro Phe 305 310 315 320 cag cct ggg gtg ctg ggc agt cgc gtg ctg cct tcc agc atg gac aag 1008 Gln Pro Gly Val Leu Gly Ser Arg Val Leu Pro Ser Ser Met Asp Lys 325 330 335 gat gag agg tcg gat gaa ccc tct ccc cag tgg cta aag gaa ttg aaa 1056 Asp Glu Arg Ser Asp Glu Pro Ser Pro Gln Trp Leu Lys Glu Leu Lys 340 345 345 350 tcc aag aag agg caagt ctt tat gag aac caa gtt tgaccaggca 1102 Ser Lys Lys Arg Gln Ser Leu Tyr Glu Asn Gln Val 355 360 gggaacactg ccacatctac gtaacagaag ccttaaccat cagaacccgc agacgaggcc 1162 gagctgctgc cgtttcttcc tgcacaacgc ttacgtgcct gggcccttcc cattggattg 1222 agaacgctat ccagtgcccc tgtcctcgcc aggctctccc tggatccaga cgggaagacc 1282 caacctccag gagcactcgc tcatctcccc agacagcact tcaggctggg aaaggagcca 1342 ggctgcccag aaacgtccat gtgggtggtt ttgcttttta tgtaaaaatt tgcatttcta 1402 cctattttag acaccttcat cagctccaag aacatcagtg tgaggctgga attgtctccc 1462 caggttctga aaaacacctg catttgtgaa agcacctcct cacccgaccc cggggcaggt 1522 ctttttttgg aaggacattt ccaaggaaga tcaaactgtt cattttctgc tgtagtctcg 1582 gtgcagggta ttaccgctgg gttgaggttt tctattcttt ttttttggtg agttccttct 1642 tccccttgag gaatcagcag ttccaatttt taaacatact ctccctgatt atgtgtat tt 1702 ctctttctag tggggctgtg tgcatcgttg gcctatgtta ttgtatgtca tttttgtttg 1762 ctttagaagg cgataaagca ataattcagc taattttctt tgaaacttga taggtatata 1822 tgtgtttacg ttaaaggaca ggaggaaaga tgtgcgaata atttgttctg aagtatccag 1882 tcacctcagg ttatcttatc cctatccaag ctgtttagaa gttataattg tcactcttgt 1942 atttatttcc atggcttctt ttcatttgag ctctggtttc agtagggtga cctttgcccc 2002 ttggccttaa gggttcataa actgcagccc aagtggtggt gcctttgctt atgaatcatc 2062 agacctgccc tagtaatctt tttctccaga gtcttctttg aacatgatgt gggctgctgg 2122 catggaggag ttgttccaaa ctggcctcag aacagatgca tgaatgaagg gtactttttg 2182 cttttgctca cctcattttc cttcatcttt cttgatgaat ccattatttg caaatgctgt 2242 caaaacatgc tttccttctc cctggccacc tctcaggagt tcatttgtct ctctatctca 2302 gcttcctccc tcatcttcct ttacccctct tctctgtctt agtgggtgga tgggcatgga 2362 tagaaatcct ctgtttcttt aggttaggat aaacacctgg gccctggtga ggcagttgct 2422 gttcagcacc agggacagca actgcagggc tgtgaggccg gagcccacct tgtgtcctgt 2482 tcgatgagct ttggttactg atgagcaatt gccagaccat gtcacccacc cagcctttta 25 42 cacctgggag cctcatgcat ctgggtttgg gagtttggcc ctgctgatga tagtttgttt 2602 tctcttcatt ccctgaatta gtcatcagtt ctccgtggcc atttggggat tcatgcctgc 2662 aactgcttca gttgaattct tttttaaaga tccagtttat gttttataat aattttgatc 2722 ttatggcttt caacgtcaat aggatcccct ttaaaaatac cctgctagtg ttttgttttg 2782 ttttgttttt ctgagacaag gtcttactct gttgctcaag ctggagtgga gtggcacgat 2842 catagctcac taacacctgg gctcaagtga ttctcccacc tcagcctccc aagtagctgg 2902 gactacaggt gtatgctacc atgaccagct aatttttaaa tatttttgta gagacaaggg 2962 tcttaccatg ttgcccaggc tggtctcgaa cttctgggct caagcaattg tccctcctca 3022 gcctcccaaa gtgctcggat tacagacatg agccactgca cctggcctga aacacattcc 3082 tagtcttttg atcctgactt cttatctggg ctgctgtctc tctttccttc aggtggaaag 3142 gaccccttgg taccatctca agcagtagga aaggacctgc tcttacatat attgatggtc 3202 ctcatgcaaa actctcaatt cttaattagt catgtctcag ctcaaggata tcagacagga 3262 atgaaacaca cttgaaaatg agattgacct ggagattttt tttccctaat ctctcatacc 3322 ttaattggaa aaataatcaa ttaattctat gttaattagg atatacaaag ttcaccctcc 3382 ttg aaagtga ctagggcaag ccctgaagat cttcctcacc tccttttatt tttctataac 3442 cttgtctcct ccagcaccac agggaagaca atcacagtgg gtcaagagct tcacgtgggc 3502 tctgccatga cctctgagac ctgcttatga tcagtgcaat gaagttagaa gtaactgatg 3562 attgggagcc tttgcagata gctgggcaaa tgggtgattt acttatcccc attctaaatg 3622 gagtgagctc tctttgaggc taagcaagga ggcgttgtat gctagtttct agactttgcc 3682 tggagacccc tttggaaatc tgtcttcttt ttaaactcac ttaatatgcc ttaatcatct 3742 gtgtgtaatg gagtcatccg ctcctcaatc taaccctcct cccctggggc tttggctgtc 3802 ctcaatgaga gtttcatgca gaatggaaaa tcctctatat gtacaatctc tctccccctc 3862 atttctcttc ctcctcacct ccaccacccc tttgcacatc agcattttaa cagctggtct 3922 tttgagaagc ctgtatcctt ttcctcttca gtagataccc ttcttcatgg tcctttgcct 3982 aatcaaacag aggcctttgg cctttgaaaa tccatgacaa ggcctcagaa atcagtgttg 4042 tggaggatta ctccatgcca ccggagaaac tctggtgaaa gagaaacctc gtggtcttta 4102 ggatgttggg attttgagtg aacctgacct gatagcctca ggattcaggg aaaggacaat 4162 cagatggcgg tgttttccag ggggacgcgc caaatcatgt ggtttcagac aattgtgttt 4222 gcctttgt gc ctccctggaa gggaggccaa ctaagggtat caccaagaag ccaaaagaga 4282 aataggcatg agcctgtggt tttaaacttt acaggctggg caaaggattt agaaagaccc 4342 ttagcatgat tttcctaaaa gagaccttag ctgctccaac ctggtgctga tagctgcttt 4402 gttgatctat gctttaaaat ttttctttat aatgccccca gatggctcct ggaactagtc 4462 gtaattgcaa actgtaaaaa tccctcctcc ccagtgtaga tatttaaacc agagtaagtg 4522 aggggagaca ttctgtggtc tctgaatgtg ccttccccct catcgtgtgt taaaacacaa 4582 aagccgaagt tccatggcgt catgattccg aggggctgga gggataggac ccactccaca 4642 tctaaagggg atctgctttg ggctcggtcc cattagcgag tgggggactc ttgctgtgtg 4702 ctaagaggct gctaggactc acccagttgg aattctgggt gggctcagga agtttagagc 4762 cacgtaaaaa gctggtaggc atgagtgtgc caggtctttg ccagcctgcg tctccttttg 4822 caccccccaa tccagagttt gctttctttt gactaaattg gctcctgcag ggggaagggc 4882 agaaagctag gccctctgct ctggaaagtc ggcctgaggt ttccggcaag ttaaccctta 4942 aaatggacac ccctcagccc gccctcccct ttggccttcc cagaatctcc ttcagtggtt 5002 gctctcacac ctgtgccata acatcatctt ccatgacttg gacgggcact tccttgacaa 5062 ttcctattgg cat cacacgg gctacaaatt atgctgtttt ctaaagaatt tgaacttttt 5122 tttttttctt ttcttgagac acggtcttgc tctgttggcc aggctggaat gcagtggcac 5182 aatcatagct cactccagcc tccaactcct gggctcaagc aatcctctca tctccacctc 5242 cagagtagcc tagatgacag gcgcacatca ccacgcccag ctgatctttt aaatctgttt 5302 tgtagaaaca ggatctcact atattgccca agctggtctt aaacttggtc tcaagtgatt 5362 ctactgcctc agcctcccaa agtgctggga ttacaggcct gagccaccat gcccagctga 5422 atttgagctt tttaataatc tcattccaca tagccttata gatcctgtaa ataggggggg 5482 tcacaaaagt aatatattgt gttatggaag ataattttgt actgtgctgt ttcctaaatc 5542 ataccaatat cctaaagtca tgcacttccc agatgatcgt gatcctccaa atgctttgta 5602 agatggggca gggcgtggaa atatatatat atacacacac acacagagac acacacacac 5662 acaagtatag tatatatttt cctaaccttt cttctgggtc cttcctcaga tctttgagtc 5722 acgatagaaa aggagctcga gttctttgtg taggaaagtt aagcttcctg cctgcggtgt 5782 tcttgcaatt gccttaggaa ttcacaagct ctaggagttc tgaacggaag gcagacgaga 5842 ggcactttat ccagtcccag aaagaatctc taaccgtgtg actgagaagt catctagaaa 5902 aacttatatt tttaatgt aa aaacaaatgg ggcttaccag acctcacaga gtattggacg 5962 tctacaagtg cttttatatt ttgtaactgt aaagaagttt catatgcaca gaagagcagt 6022 tggaaatctg gtcgactgca ataaaacaag atgacctttg catgtacgat agat tca tgcat gag atatca tgca tgca tgca tga tgca tga gatca tga <210> 158 <211> 5721 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2486) .. (2809) <400> 158 cgatgaagtg caaccttcac atgaatggga atgttatcac ctcagaccag cccatcctgc 60 tgtgagttcc aaaggcgggg tgctggggag aggcagctcc gtccatctct ttttgttcta 120 atgggtaaac tgcctgcatc acagctcccc ttcatccccc cattccgttt cctctgttct 180 aatggcagct ggccgtttca tatgcttaaa cttgaccaaa atggtttgct ttgttatttc 240 cccagggctt gaccctatag ggactagcat tatgatctcg ttctcagctt tctgatttag 300 aaatatctga gtggaagttg gagggggagg ctgcttgggt ctcctagctg tgtgcatcat 360 cccgggaaca gagaactcca ctgcatgatt ggctctgatg gagacagtgc cagatgctac 420 cccttatttt gttccccagt gaggtttttt gtttgtttgt ttgtttgttt tttgcttttt 480 cagttatttt gagagtctca ctgtgttgcc caggttggtt tcaaactcct ggggtcaagc 540 aaccctctcc cctcggcctc ctgaggacct gggactatag gcgcacacca tcacgcccag 600 ctggatttgg cttttaagta cagtgggaag ccattgaagg cttttgttgc acacagctga 660 gtatacatgc ctggcccagg actgagggat gttttgaagc ctgagatgca taaaatgttg 720 agactgtgag gacttcacct tctagataag gaagcagata ccagggagga ggttagactt 780 gccagggtga gtgggatagt gtggggcagg gctgaaatag actttgagat ttaaaaagac 840 taggatttga accctgggta atgaattatg tgatttggat aagttcttaa actgtgttca 900 aggaataaga aatatttctt agggttttgt aacctaataa gtttgggaac tactgggcta 960 aacagagtta catctgtttc actttcgggc ttctcacatt gtgtaatatg ctaatggatg 1020 ttaccatcca gaaggaacat gcagtgtttc ctaaacttaa aaccacaatt agccaggtgt 1080 ggtggcatgc acctatggtc ccagttactt ggggggccga ggtgggagga tcgcttgagc 1140 ctggaagatc gagactagtg agccatcatc atgccactgc acttcagcct gggtgacaga 1200 gtgagattct gtctcaaaaa aaaccccaca aaaccctaga acatacagca ctgcctgcgt 1260 ctccattttc tcatcagtaa ataagaaaaa cacagcctgg gccacatagc aagacctggt 1320 ctctacaaaa aattttaaaa atgagccagg catggtggta cacgcctgta gtcctagctc 1380 cttaggaggc tgtggcagga gaactgcttg agcctaggag atggaggctg atgtgagctg 1440 tgattgagtt tgctgcgagg tggaatgaga tgaaggggta tggaaagtgt tacacccagt 1500 gcctagctca tgacagatgc ccagtaaatg gtgggtcccc tccccatcta aggaaaaact 1560 gacaagaatt tttgactctt ctctgctctc cacaggcggc tgagtgacag cccatcaatg 1620 aaaaaggaga gcgagctgcc tcgcagggtg aactctgcct cctcctccaa cccccctgct 1680 gaagtggacc ctgacac cat cctgaaggca ctcttcaagt cctcaggggc ctctgtgacc 1740 acgcagccca cagaattcaa aatcaagctt tgagcagggg agtgaggcag ccagaagtgg 1800 gggcagagga gggtggctct gtttccccaa ggcaaagctt atgaccaatg ggccatcgga 1860 ctggagaccc ctgattgtgg gaagggttgc cagggataaa gagcttcctc actggatggg 1920 acccgccttt ctgtgttgtg ttctgccctg tgctcttctc tctacgttaa cgtttcctgt 1980 agtatgtttc ttcatctcat cgccaaggta ggcttgtgtt tttcagtgtg tgcctccccg 2040 agcctcagcc ccaagctgat ttcttatctg gaaatggtac actgaattct ctgggtggct 2100 ttcttgtggc cccatgggat gcagcgtggg ggctgtctga aggaccctgc tttttccagg 2160 ggccgagggg ctgcctttcc tttgtgtgta ttaagctttt caaacaatgg aggggatgga 2220 aagccctggt gtcctgacgg gagccaggtc ggcctgagag ctgtgccgct cctctgtctt 2280 gtcagtggag gtgcctgggt ggggagcagg tctcaggcct cttgtcctct ccccagtggc 2340 tccaggcctc actagtggca agggcaggat gaggctgcac cgctgggaag agtctatcta 2400 agttcttggc ttggagtccc gtgtcgtctc cgcccagagg aagttctcca gagttcacct 2460 ttcccttttc cttgagttgt gctga atg ccc cac ccc agc tct ctt tcc ctt 2512 Met Pro His Pro Ser Ser L eu Ser Leu 1 5 ctg ggt gtc ttt gct ggg agg ggg ctg tgt tgt gag ccc tcc cgg ttc 2560 Leu Gly Val Phe Ala Gly Arg Gly Leu Cys Cys Glu Pro Ser Arg Phe 10 15 20 25 tca cct cgc ctg gca ctt aac cac acc ctg gtt ttg tgt agc cgc cag 2608 Ser Pro Arg Leu Ala Leu Asn His Thr Leu Val Leu Cys Ser Arg Gln 30 35 40 ctc tct tct ggt tgg gcc ttt gaa agg ctc agc ctc cca ttg tgc agt 2656 Leu Ser Serly Ala Phe Glu Arg Leu Ser Leu Pro Leu Cys Ser 45 50 55 gct tgg gtt tgg agc tta ttt gaa tgg aag agg tca gtt tgt tcc tgg 2704 Ala Trp Val Trp Ser Leu Phe Glu Trp Lys Arg Ser Val Cys Ser Trp 60 65 70 ctc tcc att tct ggc ctc agt tgt cta cag gac agt ggt cag gga tgc 2752 Leu Ser Ile Ser Gly Leu Ser Cys Leu Gln Asp Ser Gly Gln Gly Cys 75 80 85 ctg gag gca tat atc cag ctg cca cca agg ggc act gtt tcc cac 2800 Leu Glu Ala Tyr Ile Gln Leu Pro Pro Arg Gly Thr Val Cys Ser His 90 95 100 105 tta tgt gag tgaccccatc catccatgac cagaggatta ttttcctgcc 2849 Leu Cys Glu ttggcagagg aggaggagtc aagggagcac ggcaggcta agg tgtttcccca 2909 gcataggcgc agacagttgg gacgaaactt cagagcccag gcagtccctg aatgaccagg 2969 ccagtgttgt cactgagtgg tcccctgctg gttgggagtg aagagaatcc aggctggcag 3029 agctggagcc agttggggag cacggttctg ggagctctgc aaaatcagta gcaagtgctg 3089 gaaaaggcac atgccgaaga tactcaagag ctcccaagat ttgcttgagg ctagcccagt 3149 gaagaaaaac cagagactca tgtttccagg ggtcagtctg tcaggcagga aggacccagg 3209 atttgaaccc agcttcagtg tgcaggctct gaggctgccc aggacgggaa agtccaagga 3269 aggggcctgg tggtgctcca cttgcagttc tttaaagaat gctgcttttt attctcctaa 3329 ccctttcaag tgggtgcaga cttctcgtta gcagctggaa gacattcctc ccacactttt 3389 cccttcctgg cccaagagag catccagaag gcagtaggac ctggtttttc aggtactggg 3449 agccgggggc tcactgcttg cactgtgctt agggtaggga tggtaaatat cctccctgca 3509 tggctttatc ctccctctca tcccaaagca ggtatcttct ggttgtcaca gagtttcatt 3569 gagtccagct gcagccacgt ggccatctgg agctggtgct ataggtgacc atctggtaca 3629 ttgaggggac ctgtttgcct cctccactct ataagcagtc atcttgggag accgggagga 3689 gaaggtggtg ggctagtcct gtgtcctcct ccacttccca tgcctctatg tt acccatct 3749 gtgtctcctg tgcagaagga gaggaagggg cattaagaga tgaagggtga ttatgtatta 3809 cttatccatt tctgaataaa catttgttat tcctaccttt gagttatctt tttttttttt 3869 tttttttttt gagacaaagt ctcactctgt tgccaaggct ggagtgcagt ggcactatct 3929 cagctcactg caacctccgc agccagactc aagtgatcct cccacctcag cctcccaatt 3989 agctgggact gcaggcgtgc atcaccatgc ctggctgatt tttgtagaga tgaggtttca 4049 ccgtgttgca caagctggtc ttgaaatcct gacctcgggt ggtctgcctg cctcggcctc 4109 ccaaggttgg aattaacagg cgtgagccac cacgcccagc caagggtttt aatcttgcag 4169 ggatttcaac atttggggtg gaacttaatt atttaaaaaa tagagacaga ttcttgctat 4229 gatacccagg atggtcttga actcctgggc acaagtgatc ctcctgcttc agcctctcaa 4289 agtgttggag ttacaggcat gagccactgc tccccaccag ggatgcaaat tacttgatac 4349 tcctctccag aaggtggggt cctgtgcccc tcctgaaccc aagtgtgctc tgttactact 4409 ttgaccagat gtgactctgc catttctgtg cctaggcttt taaagatggt cacttctcca 4469 tttcctgtgc ctggaacatt ctctgggagc cttgacacca catttgaagt tgcctattgg 4529 ggccagcatg gtggctcacg cctgtgatcc cggcactttg gaaggccgag gcaggca gat 4589 cgcatgaaat caggagtttg agaccagcct aaccaacgtg gtaaaaccct gtctctacta 4649 aaaattacaa aaattagagg ggcgcggtgg tgggcgcttg taatcccagc tattcaggag 4709 gctgaggcag gagaatcact tgaacccggg aggcggagtt tgcagtgagg tgaaatcacg 4769 ccactgcact ccagcctgtg caacagagcg aggctctgtc tcaaaagaaa aaaaatagtt 4829 gactgtcggt ttggcatggt ggctcatgcc tcttgtccca gcactttggg atgctgaggc 4889 aggaagatta ctggagctca ggagttcgag accagcttgg gcaatatagt gaagccctat 4949 ctttacaaaa aacgaaaaat tagctactca ggagcctgaa atggaggatc atttgtgccc 5009 aggaggcaga ggtcgcagtg agctgtgatc atgccactat actccatcct gggcaacaca 5069 gtgagacggc agaaaaaaaa aaatagttga ctattgagtc tcatatctga ttgcccacct 5129 gacatctccc ctgagtggcc taatgggcat ctcaccacgg cccacagaga actgatctac 5189 tcgattttcc ctaagctggc ccctctcctg cagtctaccc atgtcagtca atggcaacac 5249 catcctctta gttgctcaga ctgaaaagct agcagccatc ctggatttct ctcacactgc 5309 ctattcaacg tgtgaatgca tgagtggaaa gctgagttcg cactcgtgac tggccggggt 5369 cgactctgac attcactccc actttggcgc gctgatttgc ctctgagcgg atgaaggttg 54 29 agccatggcg ggcggggccg gggaggcggg cttggagcga gggggcgggg caggcgctac 5489 aaaaacgcgc tcgcgccggc gccgaaccgc aactcccggc gacccccgcg ctcccgggtg 5549 gcaagatggt ggcgcgcagg acgaagctcg cggcgcggga cccggaggac ggtatcccga 5609 gcccaccgtg ctacgcaggt gaggggatcc ggaacgcgag accggaggcg gccagcatcg 5669 ccgggaggtg tttgggggct ggcggcggcc gggggtcccc gggagcggcc gc 5721 <210> 159 <211> 5332 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1978) .. (4473) <400> 159 ggccgctcaa ccatcacaga agatcacagc caccaaaatc cccaaaagcc tccctaccaa 60 gccttcggcc ccttctactt caattgtgcc catcaaaagc ccccatccta cccagaaaac 120 agctccatct tcatttacaa agtcagccct acccactcag aagcaagtgc cacctacttc 180 ccgtccagtt cctgccagag tctcccgtcc cgcagagaag cccatccaga ggaacccggg 240 aatgcccagg cccccaccgc ccagcacccg gcccctacct cctaccacca gctcctctaa 300 aaaacccatt cccacactag ctcggactga ggccaagata accagccatg ccagtaagcc 360 ggcctctgcc cgcaccagca cccacaaacc tcccccattt actgctttat cctcatctcc 420 tgcccctact cctggttcta ccaggagtac tcggccacca gccacgatgg tacctccaac 480 ttcgggcacc agcactccca gaacagcacc tgccgtcccc actcctggct cagctcccac 540 tggaagcaag aagcccattg gatcggaagc ctcaaagaaa gccggaccca agagcagccc 600 ccggaagcct gtccccctca gacctgggaa ggcagccagg gatgtcccct tgagcgatct 660 gacaaccagg cctagcccca gacagcccca gcccagtcag cagaccaccc cggccctggt 720 attggccccg gcgcaattcc tgtcctccag cccccggccc acgagcagtg gctattcgat 780 cttccacctg gcaggatcta cgcctttccc tctgctgatg gggcctccgg gacccaaggg 840 agactgtggc ttgccgggtc cccctgggct acctgggcta cctggaatcc ctggtgcacg 900 tgggcctcgg ggtcctcctg ggccttatgg aaatccaggt ctccccggcc ctcctggagc 960 caaaggtgac atgggcttgc ctgggctctc cgggaatcca ggacctccgg gacgaaaggg 1020 acacaagggc tatcctggac cggcagggca ccccggagaa caggggcagc caggacctga 1080 gggcagccca ggggccaaag gttaccctgg caggcagggg ttacctggac cggtaggaga 1140 tcccggcccc aaaggcagca ggggctacat tgggctccca gggctcttcg gcctgccagg 1200 gtctgatgga gaacgaggcc tgcctggtgt tcctggcaag aggggcaaga tgggtatgcc 1260 ggggtttcct ggagtctttg gggaaagagg ccctcctgga ctggatggaa atcctggaga 1320 actgggcctg ccaggccccc ctggagtccc cggcctcatt ggtgacttag gagtgttggg 1380 tccgattggc tacccgggac ccaagggcat gaagggactg atgggcagcg tgggggagcc 1440 cggactgaaa gggtgaacaa ggggttccag gtgtgtcagg agatcccgga ttccaaggag 1500 acaaggggag ccaggggttg ccagggttcc ccggtgcacg ggggaagcca gggcctctgg 1560 gcaaagtcgg agacaaagga tccattgggt ttcccgggcc ccctggaccc gagggattcc 1620 caggagacat cggcccccct ggcgacaatg gcccagaagg catgaagggt aagcctggag 1680 cccgaggcct gccggga ccc cgtgggcagc tggggcccga gggagatgag ggacccatgg 1740 ggccgccagg ggcccctggc ttggagggtc agcctggcag gaaggggttt cctgggaggc 1800 ccggcctgga tggcgtgaag ggggaaccag gggatcctgg tcggccgggg cctgtgggag 1860 agcagggatt tatgggattc attggtctgg tcggggagcc aggaatcgtg ggagaaaagg 1920 gtgatcgtgg catgatggga cccccaggcg tgcctggacc caaggggtcg atggtaa 1977 gga ggt cat cct gga atg cca ggt ggt atg ggg acc cct gga gag cct 2025 Gly Gly His Pro Gly Met Pro Gly Gly Met Gly Thr Pro Gly Glu Pro 1 5 10 15 gga ccc cag ggt cct cca gga tct cga ggc cca cca ggc atg agg gga 2073 Gly Pro Gln Gly Pro Pro Gly Ser Arg Gly Pro Pro Gly Met Arg Gly 20 25 30 gca aag gga cgt cgg ggc ccc cga gga ccg gac gga cca gct ggg gag 2121 Ala Lys Gly Arg Arg Gly Pro Arg Gly Pro Asp Gly Pro Ala Gly Glu 35 40 45 caa ggg tcc agg ggc ctg aag ggc cct cca gga ccc cag ggc aga ccg 2169 Gln Gly Ser Arg Gly Leu Lys Gly Pro Pro Gly Pro Gln Gly Arg Pro 50 55 60 ggc cgg cct gga cag cag ggt gtg gct ggt gag cga ggc cac ttg ggc 2217 Gly Arg Gln Gln Gly Val Ala Gly Glu Arg Gly His Leu Gly 65 70 75 80 tcg aga ggc ttt cct ggc atc ccg ggt ccc tca ggc ccc cca ggc acc 2265 Ser Arg Gly Phe Pro Gly Ile Pro Gly Pro Ser Gly Pro Pro Gly Thr 85 90 95 aag ggc ctc cca gga gaa ccg ggc cct cag gga ccc cag ggg cca att 2313 Lys Gly Leu Pro Gly Glu Pro Gly Pro Gln Gly Pro Gln Gly Pro Ile 100 105 110 ggg cct cca gga gag atg gga ccc aag ggg ccg cct ggt gca gt gga 2361 Gly Pro Pro Gly Glu Met Gly Pro Lys Gly Pro Pro Gly Ala Val Gly 115 120 125 gaa ccg ggc ctt cct ggg gaa gcc ggg atg aag ggt gac ctt gga ccc 2409 Glu Pro Gly Leu Pro Gly Glu Ala Gly Met Lys Gly Asp Leu Gly Pro 130 135 140 ctg ggc act cct ggg gag cag ggc ctc att ggg caa cgg gga gag cca 2457 Leu Gly Thr Pro Gly Glu Gln Gly Leu Ile Gly Gln Arg Gly Glu Pro 145 150 155 160 ggc ctt gag ggt gac agt ggc ccc atg gga cct gat ggg ctg aag ggg 2505 Gly Leu Glu Gly Asp Ser Gly Pro Met Gly Pro Asp Gly Leu Lys Gly 165 170 175 gac agg gga gac cca ggg cct gat gga gaa cat ggc gag aaa ggc cag 25g Asp Arg Asp Pro Gly Pro Asp Gly Glu His Gly Glu Lys Gly Gln 180 185 190 gaa ggg ctg atg ggt gag gac ggg ccc ccc ggc ccc cct ggc gtc act 2601 Glu Gly Leu Met Gly Glu Asp Gly Pro Pro Gly Pro Pro Gly Val Thr 195 200 205 ggt gtc cgg ggt cct gaa gga aaa tca ggg aag caa ggc gag aag ggc 2649 Gly Val Arg Gly Pro Glu Gly Lys Ser Gly Lys Gln Gly Glu Lys Gly 210 215 220 cgc act gga gcc aag ggt gcc aag ggc tac cag cag ctg ggt gag 2697 Arg Thr Gly Ala Lys Gly Ala Lys Gly Tyr Gln Gly Gln Leu Gly Glu 225 230 235 240 atg ggc gtc cct gga gac cct gga ccc cct ggc act cca ggc cct aaa 2745 Met Gly Val Pro Gly Asp Pro Gly Pro Pro Gly Thr Pro Gly Pro Lys 245 250 255 ggg tcc cgg ggc agc ctg gga cca acg ggt gct ccg gga cgc atg ggg 2793 Gly Ser Arg Gly Ser Leu Gly Pro Thr Gly Ala Pro Gly Arg Met Gly 260 265 270 270 gcc caa gga gaa ccg gga ctg gct ggt tat gat gga cac aaa ggc att 2841 Ala Gln Gly Glu Pro Gly Leu Ala Gly Tyr Asp Gly His Lys Gly Ile 275 280 285 gtg gga ccc ctt gga cct cct gga cca aaa ggc gag aag cag 2889 Val Gly Pro Leu Gly Pro Pro Gly Pro Lys Gly Glu Lys Gly Glu Gln 290 295 300 ggc gag gac ggc aag gct gag ggg ccc cct ggg cca cct gga gat cgg 2937 Gly Glu Asp Gly Lys Ala Glu Gly Pro Pro Gly Pro Pro Gly Asp Arg 305 310 315 320 ggc cct gtg ggt gat cga gga gac cgc ggg gaa ccg gga gac cct ggg 2985 Gly Pro Val Gly Asp Arg Gly Asp Arg Gly Glu Pro Gly Asp Pro Gly 325 330 335 335 tac cct gga cag gag gtg caa ggc ctc cgt gga aag cca ggc cag 3033 Tyr Pro Gly Gln Glu Gly Val Gln Gly Leu Arg Gly Lys Pro Gly Gln 340 345 350 cag ggc caa ccc ggg cat ccg gga ccc cgg ggg tgg ccg gga ccc aaa Gln 3081 Gln Pro Gly His Pro Gly Pro Arg Gly Trp Pro Gly Pro Lys 355 360 365 gga tcg aaa ggc gca gag gga cca aag gga aag caa ggc aag gca ggg 3129 Gly Ser Lys Gly Ala Glu Gly Pro Lys Gly Lys Gln Gly Lys Ala Gly 370 375 380 gcc cca ggc cgg agg ggg gtc cag ggc ctg cag ggg ctg cca ggg ccc 3177 Ala Pro Gly Arg Arg Gly Val Gln Gly Leu Gln Gly Leu Pro Gly Pro 385 390 395 400 cgg ggc gtg gtg ggg aga cag gg gag ggc atc gct gga cca gat 3225 Arg Gly Val Val Gly Arg Gln Gly Leu Glu Gly Ile Ala Gly Pro Asp 405 410 415 ggg ctt cct ggc agg gac ggg caa gca gga cag cag ggg gag cag gga 3273 Gly Leu Pro Gly Arg Asp Gly Gln Ala Gly Gln Gln Gly Glu Gln Gly 420 425 430 gac gat ggg gac cct ggc ccc atg ggc cct gct ggg aag aga gga aat 3321 Asp Asp Gly Asp Pro Gly Pro Met Gly Pro Ala Gly Lys Arg Gly Asn 435 440 440ca ggt gtg gcc ggc tta cct gga gca cag gga ccc cca gga ttc aag 3369 Pro Gly Val Ala Gly Leu Pro Gly Ala Gln Gly Pro Pro Gly Phe Lys 450 455 460 ggt gag agt ggg tta ccc gga cag ctg ggt ccc cct ggc ag gga 3417 Gly Glu Ser Gly Leu Pro Gly Gln Leu Gly Pro Pro Gly Lys Arg Gly 465 470 475 480 aca gag ggc aga acg ggg ctc cct gga aac cag ggg gag cct ggg tcc 3465 Thr Glu Gly Arg Thr Gly Leu Pro Gly Asn Gln Gly Glu Pro Gly Ser 485 490 495 aaa ggc cag ccg ggc gac tct ggc gag atg ggc ttc cca gga atg gca 3513 Lys Gly Gln Pro Gly Asp Ser Gly Glu Met Gly Phe Pro Gly Met Ala 500 505 510 ggt ctc ttcga cc aag ggc ccg cct gga gac att ggc ttc aaa ggc 3561 Gly Leu Phe Gly Pro Lys Gly Pro Pro Gly Asp Ile Gly Phe Lys Gly 515 520 525 atc cag ggc cct cgg ggg cca cct ggc ttg atg gga aagga 3 Gln Gly Pro Arg Gly Pro Pro Gly Leu Met Gly Lys Glu Gly Ile 530 535 540 gtc ggg ccc ctc gga atc ctg gga cct tcg gga ctc ccg ggt ccg aag 3657 Val Gly Pro Leu Gly Ile Leu Gly Pro Ser Gly Leu Pro Gly Lys 545 550 555 560 ggt gac aaa ggc agc cgt ggg gac tgg gga ttg caa ggt ccg agg ggt 3705 Gly Asp Lys Gly Ser Arg Gly Asp Trp Gly Leu Gln Gly Pro Arg Gly 565 570 575 cct ccc gg cgg gg cgg ccc ccg ggt cct cca ggg ggt 3753 Pro Pro Gly Pro Arg Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Gly 580 585 590 cct atc caa ttg caa caa gat gat ctt ggg gca gct ttc cag acg tgg 3801 Pro Ile Gln Leu Gln Gln Asp Asp Leu Gly Ala Ala Phe Gln Thr Trp 595 600 605 atg gac acc agt gga gca ctc agg cca gag agt tac agc tat cca gac 3849 Met Asp Thr Ser Gly Ala Leu Arg Pro Glu Ser Tyr Ser Tyr Pro Asp 610 615 615 62 0 cgg ctg gtg ctg gac cag gga gga gag atc ttt aaa acc tta cac tac 3897 Arg Leu Val Leu Asp Gln Gly Gly Glu Ile Phe Lys Thr Leu His Tyr 625 630 635 640 640 ctc agc aac ctc atc cag agc att ag acg ggc acc aaa gag 3945 Leu Ser Asn Leu Ile Gln Ser Ile Lys Thr Pro Leu Gly Thr Lys Glu 645 650 655 aac ccc gcc cgg gtc tgc agg gac ctc atg gac tgt gag cag aag atg 3993 Asn Pro Ala Arg Val Cys Arg Asp Leu Met Asp Cys Glu Gln Lys Met 660 665 670 gtg gat ggt acc tac tgg gtg gat cca aac ctt ggc tgc tcc tct gac 4041 Val Asp Gly Thr Tyr Trp Val Asp Pro Asn Leu Gly Cys Ser Ser Asp 675 680 685 acc atc gag gtc tcc tgc aac ttc act cat ggt gga cag acg tgt ctc 4089 Thr Ile Glu Val Ser Cys Asn Phe Thr His Gly Gly Gln Thr Cys Leu 690 695 700 aag ccc atc acg gcc tcc aag gtc gag ttt gcc atc agc cgg gtc cag 4137 Lys Pro Ile Thr Ala Ser Lys Val Glu Phe Ala Ile Ser Arg Val Gln 705 710 715 715 720 atg aat ttc ctg cac ctg cta agc tcc gag gtg acc cag cac atc acc 4185 Met Asn Phe Leu His Leu Leu Ser Ser Glu Val Thr G ln His Ile Thr 725 730 735 atc cac tgc ctt aac atg acc gtg tgg cag gag ggc act ggg cag acc 4233 Ile His Cys Leu Asn Met Thr Val Trp Gln Glu Gly Thr Gly Gln Thr 740 745 750 cca gcc aag cag gcc gta cgc ttc cgg gcc tgg aat gga cag att ttt 4281 Pro Ala Lys Gln Ala Val Arg Phe Arg Ala Trp Asn Gly Gln Ile Phe 755 760 765 gaa gct ggg ggt cag ttc cgg ccc gag gtg tcc atg gat ggc tgc aag 4329 Gln Phe Arg Pro Glu Val Ser Met Asp Gly Cys Lys 770 775 780 gtc caa gat ggc cgc tgg cat cag aca ctc ttc acc ttc cgg acc caa 4377 Val Gln Asp Gly Arg Trp His Gln Thr Leu Phe Thr Phe Arg Thr Gln 785 790 795 800 gac ccc caa cag ctg ccc atc atc agt gtg gac aac ctc cct cct gcc 4425 Asp Pro Gln Gln Leu Pro Ile Ile Ser Val Asp Asn Leu Pro Pro Ala 805 810 815 tca tca ggg aag cag tac cgc ctg cga gtt gga gcg tgc ttc ctc 4473 Ser Ser Gly Lys Gln Tyr Arg Leu Glu Val Gly Pro Ala Cys Phe Leu 820 825 830 tgacctctga cctcgtggcc actctaggcc tcatggagga gggaagagga agaggcaagg 4533 ggagggtact gaggggcaga tgg cagg agaggcagct cccctgccca agggtccttg 4593 ggcagacccc agctgttgtc tgcccagtag aagtgggtgg gggtaggagg ggatagggtg 4653 tccttgggaa caatggatcc cagcttagcc ccaaagacca accaaagagc cagccagagt 4713 aagctggacc tgcaacctgc ctgagccccg tggcctctca gctctgcggc caccccgttc 4773 cctccccagc ttcctgccca aagagcccca cattcaagcc aacttgaggg aagggggcgt 4833 ctcgtcagct ggtccctgct agggagctat tgatgtgcaa tattagaaag gagacatgaa 4893 aaaaggagaa aaggaaagac agaagtgtat atatatatta tttaaacaaa caaaaagaag 4953 gtgcgttact attttttttt cacccgggaa agaggtgaga ggatgggaag gagcagccag 5013 gcgtgggaag cggcgagatc ctcgggctgg gggtgcccac gtttgctacc tcccactgtg 5073 aaatcgctgg tgctcgcaat tgtctctcac agtgtatgtg atttttttaa ggaaaaaaaa 5133 aaaacatccc tatttaagat tctgaaggtg ctaccattat tttgccacag actttgaaga 5193 aacttttgga tgtggggcat catccgcatc tttctctctc ctccaaatga caaagtttgg 5253 ggaatttttg aattttccta gcatcgccct tgtgctcatc aggtaatctg ctaaggagga 5313 aaaaagaaaa gaaaaaagg 5332 <210> 160 <211> 5530 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (214) .. (1323) <400> 160 caagaattac ctctttaaca tggaacaacc aggtcaaaat gtatatacat ctttaaaatt 60 gaccagtagc tactttgact tgcctaaaaa cgtaccagtg catctgctca gctgcaccgt 120 tggtgggtgc ctgtttcccc ggcccctccc tttggctaac agcacatcat ggaatcactt 180 cacaccctcc ttgtcggtga ccaagcatgg tga tgg cgc agc cct ttc ctg ttt 234 Trp Arg Ser Pro Phe Leu Phe 1 5 aaa cgg cac ggg act ctc ttt gtt gca ggc cag acg ggt gca ggg aac 282 Lys Arg His Gly Thr Leu Phe Val Ala Gly Gln Thr Gly Ala Gly Asn 10 15 20 aac tgg gcg aaa ggg cac tac acg gag ggc gcg gag ctg gtg gac gca 330n Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu Val Asp Ala 25 30 35 gtg ctg gac gtg gtg cgg aag gag tgc gag cac tgc gac tgc ctg cag 378 Val Leu Asp Val Val Arg Lys Glu Cys Glu His Cys Asp Cys Le Gln 40 45 50 55 ggc ttc cag ctc acg cac tcg ctg ggc ggc ggc acg ggc tca ggc atg 426 Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly Ser Gly Met 60 65 70 ggc acg ctg ctc atc agc agag gag gag ttc ccg gac cgc atc 474 Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Phe Pro Asp Arg Ile 75 80 85 atg aac acc ttc agc gtc atg ccc tcg ccc aag gtg tcg gac acg gtg 522 Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser Asp Thr Val 90 95 100 gtg gag ccc tac aat gcc aca ctg tcg gtg cac cag ctg gtg gag aat 570 Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu Val Glu Asn 105 110 115 aca gac gag acc tac tgc atc gac aac gag gcg ctc tat gac atc tgc 618 Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr Asp Ile Cys 120 125 130 135 ttc cgc act ctg aag ctg aca acg ccc acc tac ggg gac ctc aac cac 666 Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp Leu Asn His 140 145 150 ctg gtg tcc gcc acc atg agt ggg gtc acc acc tcg ctg cgc ttc ccg 714 Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu Arg Phe Pro 155 160 165 ggc cag ctc aat gct gac ctg cgc aag ctg gg gtg aac atg gtg ccc 762 Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn Met Val Pro 170 175 180 ttc ccg cgc ctg cac ttc ttc atg cct ggc ttc gcg ccg ctc acc agc 810 Phe Pro Heg Pro G ly Phe Ala Pro Leu Thr Ser 185 190 195 cgc ggc agc cag cag tac cgg gcc ctg acc gtg ccc gag ctc acc cag 858 Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu Leu Thr Gln 200 205 210 215 cag atg ttc gac gcc agg aac atg atg gcc gcc tgc gat ccg cgc cat 906 Gln Met Phe Asp Ala Arg Asn Met Met Ala Ala Cys Asp Pro Arg His 220 225 230 ggc cgc tac ctg acc gtg gcc acc gtg ttc cgc ggg ccc atg Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Pro Met Ser Met 235 240 245 aag gag gtg gac gag cag atg ctg gcc atc cag agt aag aac agc agc 1002 Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys Asn Ser Ser 250 255 260 tac ttc gtg gag tgg att ccc aac aac gtg aag gtg gcc gtg tgc gac 1050 Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala Val Cys Asp 265 270 275 atc ccg ccc cgc ggc ccg atg tcc acc ttc atc ggc aac agc 1098 Ile Pro Pro Arg Gly Leu Lys Met Ala Ser Thr Phe Ile Gly Asn Ser 280 285 290 295 acg gcc atc cag gag ctg ttc aag cgc atc tcc gag cag ttc tca gcc 1146 Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln Phe Ser Ala 300 305 310 atg ttc cgg cgc aag gcc ttc ctg cac tgg ttc acg ggt gag ggc atg 1194 Met Phe Arg Arg Lys Ala Phe Leu His Trp Phe Thr Gly Glu Get 315 325 gat gaa atg gag ttc acc gag gcg gag agc aac atg aac gac ctg gta 1242 Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn Asp Leu Val 330 335 340 tcc gag tac cag cag tac cag gat gac acc gcc ag ggg gag gaa 1290 Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asn Asp Gly Glu Glu 345 350 355 gct ttt gag gat gag gaa gag gag atc gat gga tagtcggaat agagccgccc 1343 Ala Phe Glu Asp Glu I Glu Glu Glu 370 caactcagat cctacaacac gcaagttcct tcttgaaccc tggtgcctcc taccctatgg 1403 ccctgaatgg tgcactggtt taattgtgtt ggtgtcggcc cctcacaaat gcagccaagt 1463 catgtaatta gtcatctgga acaaagacta aaaacagcag agaattgcgg gttctaccca 1523 gtcagaagat cacaccatgg agactttcta ctagaggact tgaaagagaa ctgaggggcc 1583 acaaaataaa cttcaccttc cattaagtgt tcaagcatgt ctgcaaatta ggagggagtt 1643 agaaacagtc tttttcatcc t ttgtgatga agcctgaaat tgtgccgtgt tgccttatat 1703 gaatatgcag tatgggactt tgaaataatg attcataata aaatactaaa cgtgtgtctt 1763 catctctcta gccatgtgca taaatgacgt aagttacttt gtatggttac aatggctact 1823 tgggtcactg gtctctccct ggggtgaact cctccccact tcagttcacg aaaacaacag 1883 aggaaagggc tcttctttaa atggaggctt taaggggggc agccaaaact gttgctagct 1943 ggaaggcaat gcagtacaga caaaagcccc tcctccatcc gcagccacct tttagactcc 2003 cacaggatct tgcattttcc caagtcaggt cctgggctag ggttccccaa ccttgtaggg 2063 gaacaaacag ccccaaaagg cctccggaca aagccagggg tgctgggtgg gagctggggt 2123 gccaacagcc agccctgcat ggaagggatg ggcccttttc tgctgtgacc catcacacct 2183 gatggcttct accaccggcc acacctttgg agtttccaaa gataaactcc acggggcacg 2243 cacagtagcc ctgctagtgc ctggtacaga cctcactgtt gacaatattt ttgctttact 2303 tcttcctgcc ctcttgaagc tgtgaacgtg ggacttgctc tagccataag aatgggcata 2363 gtgtgtcacc cccgagtgga agcgtcatgt gccagtgcca gccctcctgc tctgcctccc 2423 acgtgggcag cccccccgat ccctcctgtc cacccgtcca ggttcctgag tgaccatcct 2483 gggcagagcc cactctgacc tgtgtt ggac agggaataag agacagacaa agctttgtca 2543 ttcgggacca cttagggtta gggttcccca cagtacaacc acaacaccac ccttggtctg 2603 tgatcccagg ccttacattg actagctgta tttattttgt gttaagcccc agccttgggc 2663 agatggaaag ttcatcacta aacacagcag catggcttga ggtgatcaca gatctttttg 2723 cagaaatctg aactattctg agaccacagt aaaaataaat cttaccagct caccacccac 2783 atctgtcctg aaaacatgtt ctgtgtgacc gtggaaagat ctatgcatga gcaggcccca 2843 caagatggtg gcacagggag ccacggttgc tcctagcaca gagggccact tgcacaggtt 2903 gagcagccat ccagggccca gagcttaagg ttgctcacct caccagaaac atgggtgttg 2963 tcggtgctat ctggctttgt cactcttact gtatcaagcc tgacagacag tgggccccac 3023 tctcgtcccc cgggaggtct cacagccaag gcctgtgaga gggcagccca cgctggctcc 3083 atgccttgca gtggttggat aaggagtaga gagcgtctcc taatcgtcta ctgcctgtat 3143 ggtaaaaagc acacccagca ccctcacaac tgtgtgagcc tcagcctgga aacaatgctt 3203 cattgggcac ctcccaaaaa caccctatga ggaaaggaag tggccagtgt ggcaatgcct 3263 gcaggtgcaa aggtccagca gggggcgcct gttctcctgg catgctgagc tgtggagtcc 3323 aaacagctgc ttccacggcc tgccggggac a ggtgggtat ctcaggctgc tgggaagtag 3383 ccatgggtgg agcatgcatg gcctggggcc atggcaggga tgccactaga ttgtgttaat 3443 tctaaagcca ctgttccgac aacatcaaca ccacacaagg caagctggaa taatgctaaa 3503 acagactgct aaaaatgtaa atagttaaaa atgccagtgt ctcctccatg tccaaataac 3563 agcaattgat agaagacata gcaaatcttc ctcatgccat cttttttaag gaattttgat 3623 ataggtttgc aacactacag actcactttt ctggaagcac ataaccaata actccctttc 3683 aatagacaat aggagcagct taccagtcag accactcctg agatgtcccc agagagccag 3743 ggcccagggg actccagctt agttccactg ttccttctct aaaatccagg tgacggctca 3803 ggtcagcctg ccaggcccgc tacagttata cgttaacttc tatacccaga aggtgtggcc 3863 aacatctggc catgactggc ctcttgagga cctgcactgg ggtggttatc acagattcag 3923 gccatgacta acccctcagg acccatgtac tttatatcca gagctcagtg catctttaca 3983 ggacacataa ctctagaagg ttccaacctc ctgtgggagc taatgagaac cagcgaggct 4043 gagattttga aggattctcc tctaaaaagc aagaaaattt aatttcttgc cattatgttt 4103 tctaaaaata tccagagcat aaatagggac cctatgtgtg ttcagaaaag tacagtgttg 4163 acattttatt ttttatgtaa agaagccata tttaca taat acattcatat ttttaagtat 4223 gttacagctc ctgtagaaaa ccattccatt aagacagcaa caagtgatct ggattcaatc 4283 tttaaaatat taagtcaaat taaaatgttc ttatcaagac tccaatttaa tttcacagcc 4343 catctgcaca ggggaactga ggagaaacag gaatgaagag tgggcgacaa agagaaagca 4403 tcccttccca cacgccaaga gtccagtgca acgatccctg ccacacggtc agccgacccc 4463 acttggtgcc acagggtcca gcctcggcca ctctgggctc aacctttcca gcacgtctgg 4523 gagcccaatg aggctatggg acagtgtgca tttccctcaa ggcctccgga aagtcacctg 4583 ccacccactg tgacctctga ggctgaaagg actaaggact cctttcccca tcatttcagc 4643 tgggccagtg gctggctaaa atcagcgcag cattcccatt cttctgaaag ccacagctga 4703 aataatgcac cagctgaaac cacagtggac agactgagat ggcctccctc tgggcctcta 4763 gttggcaact ttctcacccg ggggctcctc tttctccttt tcccgctcct tgttccagtc 4823 cttaaggcct tctggaagtg aggtgtcctc atccaagctg ccagtgcctt ccacaaattc 4883 ttcataggta gatttttccg caaatggtct ggggcccaaa agttcaacca tatcattctt 4943 atctaatact tctttttcta acaacagaag agcaacctga aatatgaaca attttcatta 5003 aatacagtta ctcagcaaag tctattcaga aatattaatt t tttatttac aggtgacccc 5063 attccaaaaa aggatttaag accaatgaaa aagatgtctc atacataagg ttgcatagtt 5123 ttagagtaag atgtgcaaaa tatcaaagca accaatgtcc atctgtaagg gatacatttc 5183 catactagac atatttccac acatctgcac aatgaatgct gaccatctat aatgaggagg 5243 aagctggccg ggcgcggtag ctcgcgcctg taatcctagc acttcgggag gccgaggcgg 5303 gtggatcaca aggtcaagac catcctggcc aacagggtga aaccgtgtct ctactaaaaa 5363 tgcaaaaaaa tagctgggca tggtggtgtg cgcctgtagt cccagctact tgggaggctg 5423 aggcaggagg atcacttgaa cccgggaggc ggaggttgca gtgagccaag attgtgccac 5483 tgcactccag cctgggcgac agagcgagac tccttctcaa aacaaac 5530 <210> 161 <211> 5602 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2354) .. (3631) <400> 161 ggctccgctg cacgagctcc acgcccgtac cccggcgtca cgctcaggta ggttgggggc 60 cgggacgccg ctgctgtgag ggaggctggg tcaccgtgca gggaggggcg tcgccagggc 120 ggccgtgcct ttgcaccccg cggcccgctc cccggtcccc cagggtcccc gcgaggacgc 180 cggccccgcc cgggtgcggc gcgagtctgg cctcggcggg cacggctcgg ggcccacggg 240 ccgctcggct tcggttctcc aggctgggga cagaggctgg agccgggcgc ggtagacccc 300 gccagcctgg gccgcccgcg cccgacgcgc agcgctgctg ccaaccccgg cccgggggtc 360 cccgcagagt gggtctctgc tgccgtcagc ccttcggaga ctgtcgcgtt gaaagaatga 420 accagagttc gccccctgcc cgcgccaggg cgttttgggt caccgagtcc tgtggggacc 480 cgaggcggct gccgcccaag gccgagcgca gcctcaggac ccgcgcccca ccagacgggg 540 tcgtgcgctc cgcggcgggt ggagagccgg gctctggggt ctccgcggct cggagggcgg 600 cggggcgagg ccgtgcggcc agcgcctggg gacgcccgcg gcgggacagg ggccacccgg 660 gccgcggcgc agcctgggct gaaacctcct gggacggaac caagccacct gctgtgcgcc 720 cttctcggtg aatggcaccg ccgcccgccc gggcctctcg tccacagccc gcggtgctcg 780 cacacctgag actcatctcg cttcgacccc gccgccgccg ccgcccggca tcctgagcac 840 ggagacagtc tccagctgcc gttcatgctt cctccccagg cttccgcagc ccaccaggga 900 aggggcggta ggagtggcct tttaccaaag gtcagattct ttcaccgcct ctgccagacc 960 cccttgtccc ccacccccgc atagatctcc agggggctca gaaaactcta gccggtggct 1020 cacgcctgta gtcccaacgc tttgggaggc caaggcggga ggatcgcttg aggccaggag 1080 ttccagacca gcccaggcaa caaaagatac cacatctcta caaaaaataa attagccggg 1140 ccctgcacgc ctgtagtccc agctactggg gaggccgagg ccggaggatc gcttgagccc 1200 gggagttcca ggctgcagtg agctataatt gtgccactgc actagagtct gggtgacgga 1260 gacactgtct caaaaaaaac caacaaaacc cttagctctt tcactagccg ggctggcctc 1320 ttcctactgt aaacctgctg ggcccccgtc tcccttcttt ctcccctctc tcctgccctg 1380 gagctgcctg actctgccca cggcctgcag agaccccagg tcttcacgca aggtgccatt 1440 cctcactcag ttcttgctca aacgtccctc catcaaggag ggctttttag ctacccttgg 1500 ctatgggatc cgtcctccgc gtcagccaat tctctgcatt agactgtaac ttctcaacat 1560 acctggttcc tatgcgtttt gtgctcccct ctgagagggc agcgaccctg tcttgcttgc 1620 cactgcatcc ctagcaccta gcagttgctt ttctggtgac ggcggctgtg gcagtggcca 1680 atgcggcaga ctggtca gaa gtgaagggac aggatgactt ggcagtggag gtcaagggga 1740 ggggactggg gcagagggag acaccagagg gacaaaaatg agaaactgaa gacaggcttt 1800 gctacgtgga gctcgggcag gccacactgg tggattctgt ctcctcatcc ttcttttcag 1860 gtccctggga gaaatcagca cttagaacgt ggtgggaagg cggggcgggg tgcctcggaa 1920 gccatccctg atacaagtcc ccagctttcc tgcttcccct cttgtggtgt gtggctttgt 1980 ctccctccct ccctcctgga agccccgacc tctgaggcag gtgtaaaggg tgtgtgcttt 2040 ggtggccacg gccaccctgt ggtgctggtt ctcctccgag ggaagcagtg cactcctggt 2100 catcttggag acgcccaaca caggacccca caggcaccaa gctttttttg ggaaatggtt 2160 tcacttccca cttgaaaagc cctgaatgtc agttccacac ttagtgaatt tgatccaagc 2220 taaactgagt ctgtgcctaa aactcatcag gtgctcgagt ttcctggaag aatggctggg 2280 aacgtttatg gtgtcagctg taaagtggct gcaagtcctt ttgggaaaaa cagacccagg 2340 agtcctcaga tga tgg cag agg agg gca agg gct ggc aaa gca gct gtg 2389 Trp Gln Arg Arg Ala Arg Ala Gly Lys Ala Ala Val 1 5 10 ctt agc cca tcc tca ggg gag gga gga ctc tgg aaa gag cct gag gat 2437 Leu Ser Pro Ser Ser Gly Glu Gly Gly Leu Trp Lys Glu Pro Glu Asp 15 20 25 acg ctg aga ata aaa agt cca gag gcc agc agg gac tta gcg gct agg 2485 Thr Leu Arg Ile Lys Ser Pro Glu Ala Ser Arg Asp Leu Ala Ala Arg 30 35 40 gtg cag gtt aac tcc tgc cca act ctt ggg gac agg gac ccg ggg ctg 2533 Val Gln Val Asn Ser Cys Pro Thr Leu Gly Asp Arg Asp Pro Gly Leu 45 50 55 60 ggc cct gct cag gtg gct ctc tcc ttg cag gga ccg gcg atg ctc tgc 2581 Gly Ala Gln Val Ala Leu Ser Leu Gln Gly Pro Ala Met Leu Cys 65 70 75 agg ctg tgc tgg ctg gtc tcg tac agc ttg gct gtg ctg ttg ctc ggc 2629 Arg Leu Cys Trp Leu Val Ser Tyr Ser Leu Ala G Leu Le 80 85 90 tgc ctg ctc ttc ctg agg aag gcg gcc aag ccc gca gga gac ccc acg 2677 Cys Leu Leu Phe Leu Arg Lys Ala Ala Lys Pro Ala Gly Asp Pro Thr 95 100 105 gcc cac cag cct ttc tgg gct ccc ccacacc cgt cac agc cgg tgt 2725 Ala His Gln Pro Phe Trp Ala Pro Pro Thr Pro Arg His Ser Arg Cys 110 115 120 cca ccc aac cac aca gtg tct agc gcc tct ctg tcc ctg cct agc cgt 2773 Pro Pro Asn His Thr Val Ser Ser Ala Ser Le u Ser Leu Pro Ser Arg 125 130 135 140 cac cgt ctc ttc ttg acc tat cgt cac tgc cga aat ttc tct atc ttg 2821 His Arg Leu Phe Leu Thr Tyr Arg His Cys Arg Asn Phe Ser Ile Leu 145 150 155 ctct g gag cct tca ggc tgt tcc aag gat acc ttc ttg ctc ctg gcc atc 2869 Leu Glu Pro Ser Gly Cys Ser Lys Asp Thr Phe Leu Leu Leu Ala Ile 160 165 170 aag tca cag cct ggt cac gtg gag cga cgt gcg gct atc cg917 agc ac Ser Gln Pro Gly His Val Val Glu Arg Arg Ala Ala Ile Arg Ser Thr 175 180 185 tgg ggc agg gtg ggg gga tgg gct agg ggc cgg cag ctg aag ctg gtg 2965 Trp Gly Arg Val Gly Gly Trp Ala Arg Gly Arg Gln Leu Lys Le Val 190 195 200 ttc ctc cta ggg gtg gca gga tcc gct ccc cca gcc cag ctg ctg gcc 3013 Phe Leu Leu Gly Val Ala Gly Ser Ala Pro Pro Ala Gln Leu Leu Ala 205 210 215 220 tat gag agt agg gag ttt gat gac atc ctc cag tgg gac ttc act gag 3061 Tyr Glu Ser Arg Glu Phe Asp Asp Ile Leu Gln Trp Asp Phe Thr Glu 225 230 235 gac ttc ttc aac ctg acg ctc aag gag ctg cac ctg cag cgc tgg gtg Phe Asp Phe Asp u Thr Leu Lys Glu Leu His Leu Gln Arg Trp Val 240 245 250 gtg gct gcc tgc ccc cag gcc cat ttc atg cta aag gga gat gac gat 3157 Val Ala Ala Cys Pro Gln Ala His Phe Met Leu Lys Gly Asp Asp Asp Asp 255 260 265 gtc ttt gtc cac gtc ccc aac gtg tta gag ttc ctg gat ggc tgg gac 3205 Val Phe Val His Val Pro Asn Val Leu Glu Phe Leu Asp Gly Trp Asp 270 275 280 cca gcc cag gac ctc ctg gtc gc gat gtg gga gat gcc ctg ccc 3253 Pro Ala Gln Asp Leu Leu Val Gly Asp Val Ile Arg Gln Ala Leu Pro 285 290 295 300 aac agg aac act aag gtc aaa tac ttc atc cca ccc tca atg tac agg 3301 Asn Arg Asn Thr Lys Val Lys Tyr Phe Ile Pro Pro Ser Met Tyr Arg 305 310 315 gcc acc cac tac cca ccc tat gct ggt ggg gga gga tat gtc atg tcc 3349 Ala Thr His Tyr Pro Pro Tyr Ala Gly Gly Gly Gly Tyr Val Met Ser 320 325 330 aga gcc aca gtg cgg cgc ctc cag gct atc atg gaa gat gct gaa ctc 3397 Arg Ala Thr Val Arg Arg Leu Gln Ala Ile Met Glu Asp Ala Glu Leu 335 340 345 ttc ccc att gat gat gtc ttt gtg ggt atg tggc ctg agg Phe Pro Ile Asp Asp Val Phe Val Gly Met Cys Leu Arg Arg Leu Gly 350 355 360 ctg agc cct atg cac cat gct ggc ttc aag aca ttt gga atc cgg cgg 3493 Leu Ser Pro Met His His Ala Gly Phe Lys Thr Phe Gly Ile Arg Arg 365 370 375 380 ccc ctg gac ccc tta gac ccc tgc ctg tat agg ggg ctc ctg ctg gtt 3541 Pro Leu Asp Pro Leu Asp Pro Cys Leu Tyr Arg Gly Leu Leu Leu Val 385 390 395 395 cac cgc ctc agc cc tgg acc atg tgg gca ctg gtg aca 3589 His Arg Leu Ser Pro Leu Glu Met Trp Thr Met Trp Ala Leu Val Thr 400 405 410 gat gag ggg ctc aag tgt gca gct ggc ccc ata ccc cag cgc 3631 Asp Glu Gly Leu Lys Cys Ala Ala Gly Pro Ile Pro Gln Arg 415 420 425 tgaagggtgg gttgggcaac agcctgagag tggactcagt gttgattctc tatcgtgatg 3691 cgaaattgat gcctgctgct ctacagaaaa tgccaacttg gttttttaac tcctctcacc 3751 ctgttagctc tgattaaaaa cactgcaacc cagctaactt gtccagcata tgttgaatgg 3811 gagccaaagt gtagcaaatg ctgccaggaa cctgtcgggg cattccgggc gctgcctggg 3871 gcgctgcagt ctgggacctc aaggaaggag gctgcatagg accccaggag agacgcattt 3931 tctctttcag atgcaaacaa aatcttacac tcttctcctt tggatacaat agagaaacgg 3991 aaagaaagga aggaacaaga ggcctgtgtt aagtcctgtt gatgttaagt cctgttgaga 4051 gcaccaggta aacactctgc accccttctc ttagtagtaa taggtttttc actccttggc 4111 ctcagctgtc ctcacaggac agtgggggca gatcagagaa cacatcagaa atacatacaa 4171 agaaatcgta caaactggac aggttcccct ccccctgcca caactggcat cccaacagag 4231 ggaacaagta ctaaatcatt tttgacgacg taaataagac tgaaaacagg ttaaacagtt 4291 gctgaactta agggcatgac aaaaaggact cctctctctg acccaggtag gcaaaatgct 4351 ttgggtgtga ggtaaaaaaa atgggtaaga gcagctgtac agagtggggt gaaatgttaa 4411 acagggtgca gtgcccaagg gctaagaacc aggtccagcg caagcctgag accacaggag 4471 gcactcacag ctcacaaagg cgtctcgcct gattggccag ggcaggacct gccgcctctt 4531 ctcggtgcac agacagtcat gccaaccctg ggcagggtgg catctgcccc tgctttcccc 4591 actgagtggg gagacagggc agtgtgctca ggccctcaat cctcacgcag gtaggcctcc 4651 tgctccgact cagcccgctc ctccccttcc tcctgtgttt tctgacggag ctcttctatc 4711 tgtgcttctg ccagcttggt ttctgctttc cgggagagct ggtgcacctc ttccacctgc 4771 agttt cacca gctgaatgtg attcctggcg gttatagagg cctgatctgc gcctgccaaa 4831 agatgggaca atcgggttga gcagccgtgc agggcgcgga aggctcatgt ggacgttggc 4891 ctgggggtgc tgtggctgtc atctgaaccc ctcttggggt cactttcctt gacctccctg 4951 tcttctctct ctgcaaagaa acttccacct ctatgttcag gtctggattt aactgacact 5011 ctgtcaaaaa cagcattttt cttcagctgt cagcggccaa catcacaatt attaaatgca 5071 actctcacaa tcatctttat agctacagag cttttagtac agacctttga ttaatttttt 5131 taactacaca gcttccattt ctttttgaca aagagatcat gaataaaatt gtcaaagatc 5191 cctttcatca ccttgactaa tctttaaagg taaaggaatg catagaaaaa tattttttta 5251 ctataaattt atgtaacagc ataaaaggta ttaaatatgt tttataattt tttcacttaa 5311 acatgttttg aaggccgggc gcagtggctc acgcctctaa tctcagaact ttgggaagcc 5371 agggcaggca gatcacctga gggtcaggag ttcgagacca gcctggctaa catggtgaac 5431 ccgtctctac caaaaataca aaaaaaaatt agccaggcat ggtggcgcat gcctgtagtc 5491 ccagctactt gggaggctga ggcaggagaa tagcttggac ccgggaggcg aaggctgaag 5551 tgagccagga tcgtgccact gcactccagc ctgggcgaca gactccgtct c 5602 <210> 162 <211> 3100 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1070) <400> 162 ct ggt agg gaa acc cga cag cag ctt ccg agc tgc caa gaa gag ccc 47 Gly Arg Glu Thr Arg Gln Gln Leu Pro Ser Cys Gln Glu Glu Pro 1 5 10 15 agc ttt tcc cac ccc cac ctc ccc acc tgc cct ttc tcc tgc aag tgt 95 Ser Phe Ser His Pro His Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys 20 25 30 gac agc cgc agc ctg gag gtg gac tgc agt ggc ctt ggc ctc acc acg 143 Asp Ser Arg Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr 35 40 45 gtg ccc cca gac gtg ccc gca gcc acc cga acc ctc ttg ctc ttg aac 191 Val Pro Pro Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn 50 55 60 aat aag ctg agt gcc ctg cca agc tgg gct ttc gcc aac ctc tcc agc 239 Asn Lys Leu Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser 65 70 75 ctg cag cgg ttg gac ctg tcc aac aac ttc ctg gcc cgg 287 Leu Gln Arg Leu Asp Leu Ser Asn Asn Phe Leu Asp Arg Leu Pro Arg 80 85 90 95 tcc att ttc ggg gac ctg acg aat ctg act gag ctt cag ctg cgc aat 335 Ser Ile Phe Gly Asp Leu Thr Asn Leu Thr Glu Leu Gln Leu Arg Asn 100 105 110 aa c agc atc agg acc ctg gac agg gac ctg ctg cgg cac tcg ccg ctg 383 Asn Ser Ile Arg Thr Leu Asp Arg Asp Leu Leu Arg His Ser Pro Leu 115 120 125 ctc cgc cac ctg gac ctg tcc atc aac ggc ctg ccc cct 431 Leu Arg His Leu Asp Leu Ser Ile Asn Gly Leu Ala Gln Leu Pro Pro 130 135 140 ggt ctt ttc gac ggg ctc ctg gct ctg cgc tcc ctc tcg ctt cgc tcc 479 Gly Leu Phe Asp Gly Leu Leu Ala Aru Leu Ser Leu Arg Ser 145 150 155 aac cgt ctg cag aat ctg gac cgg ctg aca ttt gaa ccc cta gca aac 527 Asn Arg Leu Gln Asn Leu Asp Arg Leu Thr Phe Glu Pro Leu Ala Asn 160 165 170 175 ctg cag cag ctg gtc ggg gat aac ccc tgg gag tgt gac tgt aac 575 Leu Gln Leu Leu Gln Val Gly Asp Asn Pro Trp Glu Cys Asp Cys Asn 180 185 190 ctg cgt gag ttc aaa cac tgg atg gag tgg ttc tcc tac cga ggg gga 623 Le Glu Phe Lys His Trp Met Glu Trp Phe Ser Tyr Arg Gly Gly 195 200 205 cgc ttg gac cag ctt gcc tgc acc ctg ccc aag gag ctg agg ggg aag 671 Arg Leu Asp Gln Leu Ala Cys Thr Leu Pro Lys Glu Leu Arg Gly twenty one 0 215 220 gac atg cgg atg gtc ccc atg gag atg ttc aac tac tgc tcc cag ctg 719 Asp Met Arg Met Val Pro Met Glu Met Phe Asn Tyr Cys Ser Gln Leu 225 230 235 gag gac gag aat agc tca gct ggg ctgat cct ggg cca ccc tgc 767 Glu Asp Glu Asn Ser Ser Ala Gly Leu Asp Ile Pro Gly Pro Pro Cys 240 245 250 255 acc aag gcc agt cca gag cct gct aag ccc aag ccc ggg gct gag ccg 815 Thr Lys Ala Ser Pro Glu Pro Ala Lys Pro Lys Pro Gly Ala Glu Pro 260 265 270 gag ccg gag ccc agc aca gcc tgc cca cag aag cag agg cac cgg ccg 863 Glu Pro Glu Pro Ser Thr Ala Cys Pro Gln Lys Gln Arg His Arg Pro 275 280 285 gcg agc gtg agg cga gcc atg ggc acg gtg atc att gca ggg gtc gtg 911 Ala Ser Val Arg Arg Ala Met Gly Thr Val Ile Ile Ala Gly Val Val 290 295 300 tgc ggc gtc gtc tgc atc atg atg gtg gtg gcc gct gct gct 959 Cys Gly Val Val Cys Ile Met Met Val Val Ala Ala Ala Tyr Gly Cys 305 310 315 atc tac gcc tcc ctc atg gcc aag tac cac cgg gag ctc aaa aag cgc 1007 Ile Tyr Ala Ser Leu Met Ala Lys Tyr His Arg Glu LeuLys Lys Arg 320 325 330 335 cag ccc ctg atg ggg gac ccc gag ggc gag cac gag gac cag aag cag 1055 Gln Pro Leu Met Gly Asp Pro Glu Gly Glu His Glu Asp Gln Lys Gln 340 345 350 atc tct tct gtggcc tccgcc gccaggtagg aagggcgggg 1110 Ile Ser Ser Val Ala 355 agagcacacg gcattgctca gccacagctc ccaccttgac ccggcgctgg ccactgcctc 1170 cccgagtcca ccctcctccc cgccctccag cagacaagcc acaccgggtt ctctccctgc 1230 actttcgagg ctccctgaaa gccaccgtgc tgggggctcc tgctgatgct cctgtctggg 1290 ccagtaaatc tttggaacat gtgggggatc tccctaagct ctggccacag caaagcaagg 1350 aggtgtgtgc aagaggaggc ttccggactg ggcattcccc tgtcgccctt cctgccctgg 1410 ggtggccata gctggtgact cttcctacct tgctggtccc acctcacctg cattgagggg 1470 acggggaggg agggatctga gggatgaagg tagatttctg agactctctc ctaagccaga 1530 aagacgttct taacacccct gcagtgtgaa agctggtcca gctctacaac tgttggtacc 1590 aatgtgcaaa cacaccagcc ctgccatctg gacccagcac tcagaaacac catacacccc 1650 tggccgacgc catcatgccc ctggatctgc tataggccac actgaccaca tgctcctgga 1710 ttcgctaatt cactcacaca c ccattgcat caccagtgcg gtcacatgga ttgaaagaat 1770 taatacacac acacacacac acacactcac acggtcacac ggagaccgag gctatgagcg 1830 ctcgaacagc agagacatgc tcttccccag gggtctccct gagaccacag agcctctcgc 1890 gtgctcactg caatcttctc aagtcaacag caggaaggaa ctcaaccagt aacaccagga 1950 tcctttgaga tcctctaaag tgggccaaag tggtgcccct ggaggagccc tcctgtcacc 2010 atggtaaccc tctcacacct ctcctgctgg gctttcccgg gataccaccc aggggcctgg 2070 agcggctgca tgtgtgcatg gcggcctcct gaggacccag ccacacacca ctggtgttgc 2130 ctcggtcctg cccacgcatc tcacagcacc aggccctgtg gggcccccac tgattcctcc 2190 acagcctgca gcctggcacc gtgactctgt gcctctcgcc ctccatcttc agtactcctg 2250 gcctgtgact tcagggctgg gacttggtgg tgctttgcca ttggtggcac cctctgggga 2310 aagcaggtgg caggcagaga acacggtggc tcccctgagg ctcattgcct gccagcttat 2370 tgcagacaga gcccaggagc aggagcgggt ggccacgtgc tgcccagagg ctcccaggat 2430 ggggcctctg ttcccgggct ttgtctgctc agtgtggctc cctagagcac ccagccgggg 2490 ccaaaccaga gagtgggtgg ggagcctgtc tgggacagag ccacctgctg ccaaggcagt 2550 gcaagttttc caggttacct gtccccc tcc ctagctctgc ccctcctcag agtgtgaaga 2610 tggtgggtac ctaggtgtca tgctcacagg ctcaggaggc atcaggctcg tccctggctc 2670 tgggatggaa tctcgatggg ggctcaggaa gaggccagca agaaccctga agccaagggt 2730 ctgagcagag ggagttggca ggcctagctc ctgtgcccca ctccgaccct ccctgctcat 2790 gcggcagtgg gtgggtgagg tgggctgggg gcctggagga gtgcctttga ggaggtcagt 2850 cctggcaggt ggacagagga cgcctggcat gggctgctta ctgggacccc aggcggccct 2910 ggccatggcc acagtcttcc ttcttttggc gtgtgggctg gtaccagatc tggggatttt 2970 ctaaagggac tggggggagg ggagggcatt gtcaatggtg gtatctttag cctgagacag 3030 aagattttta aaggcaaaat tatatttctg gtttgttgtt tcagaagacc aataaagact 3090 gtattttcct 3100 <210> 163 <211> 5892 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1984) .. (3159) <400> 163 gcggaggccg tggagcgcac tgacgagctg gtccgggagt acctgctctt ccgcgggttc 60 acgcacacac tgcggcagct ggacgccgag atcaaggcgg acaaggagaa ggggttccgg 120 gtggataaga ttgtggacca gctgcagcag ttaatgcagg tgtatgactt ggctgccctt 180 cgggattatt ggagctactt ggagcgtcgg ctcttcagcc gcttggagga tatatacaga 240 cccacaatcc acaagctgaa aaccagcctg tttcgatttt atcttgtcta cacaatccag 300 acaaacagaa atgacaaggc tcaggagttc tttgcaaagc aggccacgga actccagaac 360 caggctgagt ggaaggattg gtttgtcctg cccttcctgc catccccgga caccaacccc 420 acctttgcta cctacttttc tcgacagtgg gctgacacct tcattgtgtc cctgcacaac 480 ttcctgagcg tcctgtttca gtgcatgcca gtccctgtga tcctgaactt tgatgcggag 540 tgtcagagga ctaaccaggt tcaagaagaa aatgaagttc tgcgtcagaa gctttttgca 600 ttgcaagctg aaatccaccg actgaagaaa gaggagcaac agccagaaga ggaagaggcc 660 ttggtccaac acaaattgcc tccttatgtc tccaacatgg accgcctggg ggactcggaa 720 ctgtgagtgt gtgtgacggc cctttccttt tctttgccct ctgtgctctc agccccacag 780 ttccctctga tcttgccttg cctgcagtcc tctgtgcctg ctgaaggaga attgcggaag 840 agcctcctgg cacacactgc tcttgcttga gagctttatt tttattttta gagatggagt 900 ctcgctctgt cgcccaggct agagtgccgt ggcacaatct tggctcaaag caacttctgc 960 ctcctgggtt caagagactc tcctgcctca gcctcccaag tagctgggat tacaagtgca 1020 tgccaccatg cctggctaat tttttttgta tttttagtag agatgggatt tcatcgtatt 1080 ggccaggcta gtcccaactc ctgacatcaa gtgatccacc tgccttggcc tcccaaagtg 1140 ctgggattac aggcgtgagc caccgtgtcc agccttgctt cagagcttta tgagtaaggt 1200 ccccatggcc tcagaagtcc tctaggagtt ctgagcctcc gagcctgtgg ctctgcctag 1260 aggtggggaa ctgcacagct ctgccagctc tacatccaga tatgtgtagt caggataaat 1320 aaaaacgcaa ccactgtggt aaagtcttgg gaaggttttg tgcattggaa ggagcatctc 1380 atgtatggaa agattggtaa ccacaggttg gatgcattcc tcagtagaag catgcacctc 1440 tctgacggtt taaagaggaa ggcagattag agagaggtat ttgaccttca gaaacagcca 1500 gttaaagcag aagcccagct ggtgataata atagtagtgg ttgaagaaac agaggtacac 1560 acaggtgagg aagacagtga ttggtgagtc acgatgcaaa cccaggcagc cggattccag 1620 acctccacat agccaagtat tgcaccagat gaaatagctc tagtggtggt gccagttctt 1680 tctgatggaa ataaaat gcg agccaaatac gtaatttaat ttttttagta gctatgttaa 1740 aaaaaaaaac aagatgaagt taattttaat gatatatttt atttggccta gtatattcaa 1800 aacatcattt caatatgtaa tggatataaa caaaatgtta atgagctatt ttattctttt 1860 catgccaagt ctttgaattc cagtgtcaat tttacatctc tagcacatct tgatttggac 1920 taaccacatt tcatttgctc agtagcacac gtgaccagtg gctattggac aagacagctc 1980 tga gtt tac tgt gac cct caa aga aga gcc gca gac ttc acc ctt gta 2028 Val Tyr Cys Asp Pro Gln Arg Arg Ala Ala Asp Phe Thr Leu Val 1 5 10 15 aca gat aag ctg ctg gct ccc ttt gtg caa aaa aat gat gcc aag gat 2076 Thr Asp Lys Leu Leu Ala Pro Phe Val Gln Lys Asn Asp Ala Lys Asp 20 25 30 aat acc acc tta aag ccc agg ctc ttg gac ctg acc cag gcc tgg tca 2124 Asn Thr Thr Leu Lys Pro Arg Leu Leu Asp Leu Thr Gln Ala Trp Ser 35 40 45 ctt aac gtc atc cgt agc ccg gga ggt cta tgt tct tgg ttt ttc cac 2172 Leu Asn Val Ile Arg Ser Pro Gly Gly Leu Cys Ser Trp Phe Phe His 50 55 60 atc ctg ttt cag ccc tct gac cct gtg gtg tgt ttg ctg acc agt gcc 2220 Ile Leu Phe Gln Pro Ser Asp P ro Val Val Cys Leu Leu Thr Ser Ala 65 70 75 atg gtg tgc agc caa agg aat gcc tcc ctc tcc cag tca ctt cgt gtg 2268 Met Val Cys Ser Gln Arg Asn Ala Ser Leu Ser Gln Ser Leu Arg Val 80 85 90 95 ggc ttc ctg tcc tcg ctg ctg cct cag agt aag aag agc ccc tca agg 2316 Gly Phe Leu Ser Ser Leu Leu Pro Gln Ser Lys Lys Ser Pro Ser Arg 100 105 110 ttg tcg cct gct cag ggc cct cct caa cct cag agc tg aaa 2364 Leu Ser Pro Ala Gln Gly Pro Pro Gln Pro Gln Ser Ser Ala Lys Lys 115 120 125 gag tcc ttc ggt ggt cag ggc acc aag gga aag gac ccg acg tcc gga 2412 Glu Ser Phe Gly Gly Gln Gly Thr Lys Gly Lys Asp Pro Thr Ser Gly 130 135 140 gcc aag gat ggg aag agc ctc ctc agc ggg ctg gcc act ggg gag tcc 2460 Ala Lys Asp Gly Lys Ser Leu Leu Ser Gly Leu Ala Thr Gly Glu Ser 145 150 155 ggt tgg tca cag cac cgg cag cgg cgc ctg cag gac cat ggc aag gag 2508 Gly Trp Ser Gln His Arg Gln Arg Arg Leu Gln Asp His Gly Lys Glu 160 165 170 175 agg aag gag ctt ttc tcc aca acc act tcc cag tgt gca gag aag aaa 2556 Arg Lys Glu L eu Phe Ser Thr Thr Thr Ser Gln Cys Ala Glu Lys Lys 180 185 190 cca gaa gcc agt ggc cca gag gct gag ccc tgc cca gag ctc cac acg 2604 Pro Glu Ala Ser Gly Pro Glu Ala Glu Pro Cys Pro Glu Leu His Thr 195 200 205 gag cca gtg gag cca ctg act cgg gca tcc tcg gca ggc cct gag ggt 2652 Glu Pro Val Glu Pro Leu Thr Arg Ala Ser Ser Ala Gly Pro Glu Gly 210 215 220 gga gga gtc cgc ccc gag cag ccc ttt att gtg ctg gga cag gag gag 2700 Gly Gly Val Arg Pro Glu Gln Pro Phe Ile Val Leu Gly Gln Glu Glu 225 230 235 tac ggg gaa cac cac tca tcc atc atg cac tgc aga gtg gat tgc tct 2748 Tyr Gly Glu His His Ser Ser Ile Met His Cys Arg Val Asp Cys Ser 240 245 250 255 ggg agg aga gtc gcc agc tta gac gta gat ggg gtc atc aaa gtg tgg 2796 Gly Arg Arg Val Ala Ser Leu Asp Val Asp Gly Val Ile Lys Val Trp 260 265 270 tcc ttc aac ccc atc atg cag acc aaa gca tcc tcc att tcc aaa tca 2844 Ser Phe Asn Pro Ile Met Gln Thr Lys Ala Ser Ser Ile Ser Lys Ser 275 280 285 ccg ctg ctg tct ttg gaa tgg gcc acc aaa cgg gac aga ctg gtg ag t 2892 Pro Leu Leu Ser Leu Glu Trp Ala Thr Lys Arg Asp Arg Leu Val Ser 290 295 300 aat ggt ggc ctg tgg ggc ccg ctt tgc tgg ctc agt gga gga att ccc 2940 Asn Gly Gly Leu Trp Gly Pro Leu Cys Trp Leu Ser Gly Gly Ile Pro 305 310 315 cag ggt tct cca ccg gct gag tca aga cag cca agc cag ttc ccc tcc 2988 Gln Gly Ser Pro Pro Ala Glu Ser Arg Gln Pro Ser Gln Phe Pro Ser 320 325 330 335 ctt ctc tcc att att atggg gat tca ggg aca cac atc cag gac tgg ccc 3036 Leu Leu Ser Ile Ile Gly Asp Ser Gly Thr His Ile Gln Asp Trp Pro 340 345 350 aga agg ctc ctg ttg tgg gaa gac agg gag gtt acc aga ttg aca gat 3084 Arg Arg Leu Leu Leu Trp Glu Asp Arg Glu Val Thr Arg Leu Thr Asp 355 360 365 gga aat gag ctg cag ggg gcc tgg aac aca cgg ctt ctt cct gtt tgt 3132 Gly Asn Glu Leu Gln Gly Ala Trp Asn Thr Arg Leu Leu Pro Val Cys 370 375 380 ggt ggt ccg ccc tgg gga cca cct gcc tgactgctgt ccctccattt 3179 Gly Gly Pro Pro Trp Gly Pro Pro Ala 385 390 gtctgtgttt ccagctgcag tttcagtggg cgccctcccg tgccaggccc cacgggaagtc239 t ggtgaggggc tggtgttcta ttttgtggtt cccatgggtc ttattgtccc 3299 caggaatagt acagtgttct tccctctgga tttgatattt gagataggac ttgtagttaa 3359 ggaggtaaaa ttgccttgct gttttttctt ttacttcatt tgtggggatc ataccacata 3419 gcccaagatg caaaccctgt ttttctataa tttttggcag ctgaagggat tatcctcatg 3479 gatgaggacc tcagggcttg ccctgtgcca gcgccagttt gccaagtgaa tgccgaggtc 3539 acactctacc taatattcct gtgagacacc ctcagacctg ggctgcttct ggcactttcc 3599 tctggcacta ttattatctt tgaagctttt caccaaataa gtcacaagtt cctgaaggca 3659 aggatagccc cttttatttt tttttctgga ggtctttaca gacccagagc cagagctgtc 3719 ccctgaaaag gcaaatggga gtcacccagg ccctgtggca gccgaagcga gtacgctggg 3779 aggggtgctg ggcagaccaa gagtgggaag gaagggttcc aacagctggg gtttcaaact 3839 gaagaaaggg aggatcagag ggcctcattc accagccaga acatttccat atgtgtccaa 3899 ggtgacgcgt ctctcccatt ccacagatgc tttttgtggt tttgcttaga agttcaaggt 3959 cagctctcac gtctttgttt aattttaaag tgaggctcat tgtagccaga tttcccctga 4019 actgcctgga tgcgtagagg aggggcctca cccccacagc ctgcccagcc tcaccccctc 4079 tggagatcct ccc tgactca gcctcactcc atgctatcct tcccacctcc cgccccttgt 4139 cattccagct cttgctgggc agtggtgtgg gaacagtgcg tctctatgac acggaagcca 4199 agaagaatct ctgtgaaatc aatatcaacg acaacatgcc cagaatcctg tctcttgcgt 4259 gcagccccaa cggggcctct ttcgtctgtt cggcagcagc tccgagcctc acttcccagg 4319 tggacttctc agcaccagac atcggcagca agggcatgaa ccaggttcct ggcaggctgc 4379 tgctgtggga cacgaaaacc atgaagcagc agctccagtt ctccctggat ccagaaccca 4439 ttgctatcaa ctgtacagcc ttcaatcaca acgggaacct gctggtcaca ggggcagctg 4499 atggcgtcat ccggctgttt gacatgcagc agcatgagtg cgcgatgagc tggagggccc 4559 actacgggga ggtctactct gtggagttca gctatgatga gaacaccgtg tacagcatcg 4619 gcgaggacgg gaagttcatc cagtggaaca tccacaagag tggcctcaag gtatccgagt 4679 acagcctccc ctcagatgcc acgggcccct ttgtgctgtc tggatacagc ggctacaagc 4739 aggttcaagt ccccaggggc cgactcttcg cttttgactc agagggaaat tacatgctga 4799 catgttctgc cacaggcggc gtcatctaca agctgggtgg cgatgagaag gttctggaga 4859 gctgcttgag cctaggtggc caccgagccc ctgtggtcac cgtggactgg agcactgcca 4919 tggactgtgg gacctgcct c accgcctcca tggatggcaa gatcaagctg accaccctcc 4979 tggcccataa agcctgatga cttgccccaa gggccacccg aggaagcagt attatctgcg 5039 gtggggggag gagatatagg acaggaaaac cacgtgctcc actccagctc cctgccagtg 5099 cagtgactct gcagggaaag actggcaagg aggctcaggt gcttccatct gtggtgactg 5159 gaatgggacc cacgtggagt aggtgacata tgcttcccag agactggtat tgtggctgtg 5219 ccaggagtac atgtgagact atgggaggaa agctccggaa gaaggagaaa cattgcagtg 5279 gctactgtgt tggcccagta gaaattgaca gtattttgta tatatgtgcc catttatctt 5339 tttctttttt aaaaaaagag aatactcttg tggtcccctg atgtctcttt ctaggatgtg 5399 tgtcactttg cttcagtgac agccctccca cccagcctgg ctctgctggc cccgaactga 5459 acctctccag gctctcctgt tgctttgcca tggagccagg tcagctctct gtctgttctg 5519 ctgggtaaca aggtttggca gttcctgttt ctctgggctt aagtcaaggc cacagaattc 5579 tttttcttcc ctgaaagctg gcagcttttg ttacagaaga ttctcaggat gaaggcaggg 5639 gctgaggcct ctgctactgg ctgccccttt ccatccagtg gctgctgttt cccaagacgg 5699 gctaagcgtt tcttatctga aatgcttggg acaggagtgt tacagatttt ggattttttc 5759 agactttgga atatttgcat ata tacataa tgaggtatct tggtaggtct catgtctaaa 5819 catgaaattc attcatgttt tatatatacc ttatacatgt agcctgaagg taactctata 5879 cagtatttta aat 5892 <210> 164 <211> 5409 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1102) .. (2337) <400> 164 gcagggcggt cacggcggcc tgcccagggc gcagcggggt cgacctttgt gcggggcggg 60 tccctggcag cctcggcccg gactcgccgc caacgaggag ccgagcgccc tggagaacgc 120 gtcggggctg agccggggtc cagcagccgc cgctatggac atcccgccgc tggccggcaa 180 gatcgcggcg ctgtcgctga gcgccctccc ggtgtcctac gcgctcaacc acgtctcggc 240 gctctcgcac cccctgtggg tggcattgat gagcgcccta atcctgggtc tgcttttcgt 300 ggcggtctac agcttgtccc atggcgaggt ctcctatgac ccactctatg ctgtcttcgc 360 tgtcttcgcc ttcacctcgg ttgtggacct catcatcgct cttcaggaag acagctatgt 420 ggtgggcttc atggagttct acaccaagga ggtacttggg ggacgaccag ggagccccct 480 accgcactgc ccgtctgagt ctcccacctg cccccacagg gagagccata cctgcgcaca 540 gcgcacggag tcttcatctg ctactgggat ggcactgttc actacctcct ctacctggcc 600 atggccggcg ccatctgcag aaggaagaga taccggaatt ttggactcta ctggctgggt 660 tccttcgcca tgagcatcct ggtgttcctt acaggaaaca ttcttggtgc aagaggaaca 720 aagaaaggga ctcctgcagc gtccggctga cctggccctt gtcatatatc tcatccttgc 780 tggcttcttc actctgttcc ggggcctggt ggtgcttgat tgccccacag atgcctgctt 840 tgtctatatc taccagtatg agccatacct gcgggaccct gtggcctacc ctaaggtgca 900 gatgctgatg tacatgtttt atgtcctgcc tttctgcggc ctggctgcct atgctctcac 960 cttccctggt tgctcctggc ttccagactg ggccttggtg tttgctggag gcatcggcca 1020 ggcagacgcc gggattgcgc cgcctgcagg gacctgccca gtcttaaccg ggtgtgcggg 1080 gagcgcagtc cgggtgcgta g ggg ccg ctc ggc ggg ggc cgc gcg ggc aag 1131 Gly Pro Leu Gly Gly Gly Arg Ala Gly Lys 1 5 10 atg gtg tgc gct cgg gcg gcc ctc ggt ccc ggc gcg ctc tgg gcc gcg 1179 Met Val Cys Ala Arg Ala Ala Leu Gly Pro Gly Ala Leu Trp Ala Ala 1520 25 gcc tgg ggc gtc ctg cg ctg cg ctg cg cc gcg ggg gcg cag cgt ggc 1227 Ala Trp Gly Val Leu Leu Leu Thr Ala Pro Ala Gly Ala Gln Arg Gly 30 35 40 cgg aag aag gtc gtg cac gtg ctg gag ggt gag tcg ggc tcg gta gtg 1275 Arg Vals Lys Vals Leu Glu Gly Glu Ser Gly Ser Val Val 45 50 55 gta cag aca gcg cct ggg cag gtg gta agc cac cgt ggt ggc acc atc 1323 Val Gln Thr Ala Pro Gly Gln Val Val Ser His Arg Gly Gly Thr Ile 60 65 70 gtc ttg ccc tgc cgc tac cac tat gag gca gcc gcc cac ggt cac gac 1371 Val Leu Pro Cys Arg Tyr His Tyr Glu Ala Ala Ala His Gly His Asp 75 80 85 90 ggc gtc cgg ctc aag tgg aca aag gtg gtg gac ccg ctg gcc ttc acc 1419 Gly Val Arg Leu Lys Trp Thr Lys Val Val Asp Pro Leu Ala Phe Thr 95 100 105 gac gtc ttc gtg gca cta ggc ccc cag cac cgg gca ttc ggc agc tac 1467 Asp Val Phe Val Ala Leu Gly Pro Gln His Arg Ala Phe Gly Ser Tyr 110 115 120 cgt ggg cgg gct gag ctg cag ggc gac ggg cct ggg gat gcc tcc ctg 1515 Arg Gly Arg Ala Glu Leu Gln Gly Asp Gly Pro Gly Asp Ala Ser Leu 125 130 135 gtc ctc cgc aac gtc acg ctg caa gac tac ggg cgc tat ggg cgc tat 1563 Val Leu Arg Asn Val Thr Leu Gln Asp Tyr Gly Arg Tyr Glu Cys Glu 140 145 150 gtc acc aat gag ctg gaa gat gac gct ggc atg gtc aag ctg gac ctg 1611 Val Thr Asn Glu Leu Glu Asp Asp Ala Gly Met Val Leu Asp Leu 155 160 165 170 gaa ggc gtg gtc ttt ccc tac cac ccc cgt gga ggc cga tac aag ctg 1659 Glu Gly Val Val Phe Pro Tyr His Pro Arg Gly Gly Arg Tyr Lys Leu 175 180 185 acc ttc gcg gag gcg cag gc gcg tgc gcc gag cag gac ggc atc ctg 1707 Thr Phe Ala Glu Ala Gln Arg Ala Cys Ala Glu Gln Asp Gly Ile Leu 190 195 200 gca tct gca gaa cag ctg cac gcg gcc tgg cgc gac ggc ctg gac Agg Ag Ser A Glu Gln Leu His Ala Ala Trp Arg Asp Gly Leu Asp Trp 205 210 215 tgc aac gcg ggc tgg ttg cgc gac ggc tca gtg caa tac ccc gtg aac 1803 Cys Asn Ala Gly Trp Leu Arg Asp Gly Ser Val Gln Tyr Pro 225 230 cgg ccc cgg gag ccc tgc ggc ggc ctg ggg ggg acc ggg agt gca ggg 1851 Arg Pro Arg Glu Pro Cys Gly Gly Leu Gly Gly Thr Gly Ser Ala Gly 235 240 245 250 ggc ggc ggt gat gcc aac ggg ggc acg cg tac ggg tat cgc cat 1899 Gly Gly Gly Asp Ala Asn Gly Gly Leu Arg Asn Tyr Gly Tyr Arg His 255 260 265 aac gcc gag gaa cgc tac gac gcc ttc tgc ttc acg tcc aac ctg ccg 1947 Asn Ala Glu Glu Arg Phe Cys Phe Thr Ser Asn Leu Pro 270 275 280 ggg cgc gtg ttc ttc ctg aag ccg ctg cga cct gta ccc ttc tcc gga 1995 Gly Arg Val Phe Phe Leu Lys Pro Leu Arg Pro Val Pro Phe Ser Gly 285 290 290 295 gct gc g cgc gcg tgt gct gcg cgt ggc gcg gcc gtg gcc aag gtg ggg 2043 Ala Ala Arg Ala Cys Ala Ala Arg Gly Ala Ala Val Ala Lys Val Gly 300 305 310 cag ctg ttc gcc gcg tgg aag ctg cag cg cg cg cg gag gcg 2091 Gln Leu Phe Ala Ala Tla Lys Leu Gln Leu Leu Asp Arg Cys Thr Ala 315 320 325 330 ggt tgg ctg gcc gat ggc agt gcg cgc tac ccc atc gtg aac ccg cga 2139 Gly Trp Leu Ala Asp Tly Ser Ala Ile Val Asn Pro Arg 335 340 345 gcg cgc tgc gga ggc cgc agg cct ggt gtg cgc agc ctc ggc ttc ccg 2187 Ala Arg Cys Gly Gly Arg Arg Pro Gly Val Arg Ser Leu Gly Phe Pro 350 355 360 gac gcc acc ttc ggc gtc tac tgc tac cgc gct cca gga 2235 Asp Ala Thr Arg Arg Leu Phe Gly Val Tyr Cys Tyr Arg Ala Pro Gly 365 370 375 gca ccg gac ccg gca cct ggc ggc tgg ggc tgg ggc tgg gcg gg Agg gg Agg gg Agg gg Agg gg Agg Pro Pro Ala Pro Gly Gly Gly Trp Gly Trp Gly Trp Ala Gly Gly 380 385 390 ggc ggc tgg gca ggg ggc gcg cgc gat cct gct gcc tgg acc cct ctg 2331 Gly Gly Trp Ala Gly Gly Ala Arg Asp Pro Ala Ala Trp Thr Le u 395 400 405 410 cac gtc taggctggga gtaggcggac agccagggcg cttgaccact ggtctagagc 2387 His Val cctgtggtcc cctggagcct ggccacgccc ttgaagccct ggacactggc cacattccct 2447 gtggtccctt acaaactaac tgtgcccctg gggtccctga agactggcta gtcctggcag 2507 aacagtactt tggagttccc tggagcctgg ccagccctca cctcttctgg atagaggatt 2567 cccccaactc cccaactttc tccatgaggg tcacgccccc tgaggacctc aggaggccag 2627 cagaacccgc aggctcctga agactggcca cgcctcctga gaccacttgg aaacagacca 2687 actgcccccg tggtcgcctg gtggctggac ccccgggatt gactagagac cggccgtaca 2747 ccttctgcat ctcactggag actgaacact agtcccttgc ggtcacgtgg gacactgggc 2807 gcctcctcct ccccctcctc ctcacctgga gagactacag gaacttcagg gtcactcccc 2867 gtggtcacat ggaggttgtg ggccgaggcg cttattttcc cttatggtga cctgagtcct 2927 ggagactccc attctccccc tctccctgag agtcccctgc agtttctggg taacagggca 2987 cacccctcta gtttcatggg cgagcacccc catctgccac ctcagactga cacacagcca 3047 gctggctcac ttactggggg ccacgtccca cccctcagat atttctttga agggagagca 3107 aacccaccct gtcctctgac gtccctttcc caactgtcac caaacagac c atcttcccag 3167 gcctggggac cggtaagatc catgtcacta gttatgcaga gcagttgcct tgggtcccac 3227 tgtcaccaag gcaaccagtc ctgctgctac ctgtcaccta gagtcacaca ccccttccct 3287 catcaggcac acccatgaag acagtgcctc cctcctccag ctgtaaccat ggataccaca 3347 catttctcat ctcattggcc cccaccccag agacctccac ctcaacttct ggctgtccct 3407 accctgactc accgccatgg agatcaccct ccccgaagct gtcgccaggg tgacccaaca 3467 tccagttctc cggctctcac catggaaaca aactgtccct gtccccaggc ccactccagt 3527 tccagaccac cctccatgct ccacccccag gcggtttgga ccccaccact gttgccatgg 3587 tgaccaaact ctggagtccg aggtaacaga acacctgtcc ccctaggctt ttccttgtgg 3647 acaacggggc cctgttcacc aagctgttgc catagagact gtcaacgttg tcctcatgac 3707 aaccagactt ccagttctca ggaacttctc attgtgggcc agaagtcctg ggtgcctcct 3767 actagggcta ccctactgca ccccatcagg ggcctgatgg ctgccccttc cccagacagg 3827 gctggacttc tggagctgct aagccaccct ccgtttgcac gttaactcta tgccggatag 3887 cagctgtgca cgagacaatc ttgcaacacc cgggcatgtt tgtcgtcgtc ctacaaatga 3947 ggaaaccgag cctatggcgt gccctggtct gttgagatat gcaagcactg agc tcctctt 4007 ttgtcctctg agaccccatc tccattctca cccagttcct ctctccttcc ctgaccccca 4067 cccacatttc cctccttaga gatccaggag ggatggaatg ttctttaaaa ttcaacaccc 4127 accaggctct aagcggcgat ctgtgctaag aggtcaggac ccagccgaag tcctcggcgt 4187 tgacaggcag ctggggggac atgatccatg gacaaggcca tcccggccgt gggagacccc 4247 agtcccgaag tcttgcctgc aggagtactg gggtccccct ggggccctct ttactgtcac 4307 gtcatctcta ggaaacctat ctctgagttt tgggaccagg tcggtttggg tttgaattct 4367 gcctcttctt gctcactgtg tgaccaagtg acaaactcct tctgaacctg tgttctccca 4427 ctgtaccagg gctgttctgt ggtccccgtg agtgccaagc atacagtagg ggctcaataa 4487 atccttgttt cttttgatga atgagaaaat gaggcagcca gtgggtaatt cctgtataaa 4547 tgcactttgg tagataagat gttacaagct tggggggctt ggggtttttt ttgttttgtt 4607 tttttgagat ggagtcctgc cctgtcgccc aggctggagt gcagtcgtgc aatcttggct 4667 cactgcaacc tctgcctccc gggttcaagt gattctcctg cctcagcctc ccgagtagct 4727 gggattacag gtgcctgcca ccacacccgg ctaatttttg tatttttagt agagacaggg 4787 tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caggtgatct acccacct cg 4847 gcctcccaaa gtgttggggt tacaggtgtg agccactgcg cctggccggg cttgattttt 4907 attctctttg gaagtggggt ccttcattcc tcccccacct ccccaatctc ttgctcctct 4967 ttcttccccc atcctgtgcc cactgtctcc ctttagccac ccaccatggg tctgctcctt 5027 gtcaactctg tcctgactgg gtcattgaca agatccaggg catgaaattc gggaaactgg 5087 aaggggggtt cctgtaccag gaagggagag acattacaaa ctttccctga catgaatatg 5147 tgggctgagg gcaggggctg aggaagcact ggaagtttct aggatacaac aaagcatgaa 5207 gagaaaaaat agtgtaaggt cctgaccgtg cacagtggat catgcctata atcccagcac 5267 tttaagagac caaggtggga ggattgcttg agccagaagg tcgaggctgc agtgagccat 5327 gattgtacca ctgcactcca gcttgggcga cggagtgaga ccctgtctca aaaaataaaa 5387 ataagtaaat ctcctcttcc tc 5409 <210> 165 <211> 5427 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2937) .. (3413) <400> 165 cgctgccggg ccggggctgg gccggagcgg cggcgcctgg atgccggccc ggggctgggc 60 cggagactgg cgcccgcccc gaagcgactt tcggtccccg acccgctccg cctgacccct 120 atgatgaaga gggcgtccac tggagttctt gctgtcgaca tctttgacaa gttcaacttc 180 acgggagcca gagtcccatg gttcgacgcc attcatgaag aattccccag ggagctggag 240 tcctccatct ccttcccagc caacttcttc aaaccacctg aagaaaaagt gcttaggtag 300 aggttgagca tcctaatcct gaaatctgaa atgctccaga atctgaacct tcttgagcac 360 caacctgaca cttaaaggaa gtgctcattg gaggatctgt gacaattact aaaaacttcc 420 ccaaataaaa aggacatgaa aagaatctca cgctatcgcc caggctggag tgcagtggcg 480 cgatctccgc tcactgcaag ctccgcctcc cgggttcgcg ccattctcct gcctcagcct 540 cccgagagta gctgggactg caggcgcccg ccaccacgcc cagctaattt tttgtatttt 600 tagtggagac ggggtttcac cgtgttggcc agaatggttt cgatctcctc acctcgcgat 660 ccatccgcct cagcctccca aagtgctggg attacaggcg tgagccaccg tgcctggccc 720 tcatgtgtct taaaaagagg ggtgactctg atgtggggtc atgcttgaaa ctgagaggac 780 gaggtccccg accctccatt gcagccagct ctctctggaa ctaacagagt gagaactcgc 840 tcattaccaa ggggaggaca ccaagccatt catgggggac ccacccccat gacccaaaca 900 accccgacca cgcccacctc caacccttaa gcagtccatc tccagaactc ttttcatcct 960 gcagatctga aactctagcc cacaaaacac caactccact ccccagccac tggtgcccac 1020 cgttgtttct gtctctgaat ttgactcctc tagggacctc ccataagtgg aatcatacaa 1080 tatttgtcct tttgtgcttg gcttatttca ctgagcgtaa tgttctctag gttcacctgt 1140 gttgtagcaa acgtcagact ttccctcctt ttgaaggctg agtaatattc tgttgtgtgg 1200 atggagcacg cattgtttat ccactcacct gttgacgcat gcctgggtcg tttccacctt 1260 tcggcctgtg tgaatggtgc tgctctgaac aggggtgaag acgtatctgg gcgtctgctt 1320 tcagttcttt tgggtgtata cccagaagtg ggcttgctgg gtcacgtggt aaatcctgtg 1380 gttgattttt tgaggacgca ccatactgtt ttcggtggga catctgttgg gttttgagaa 1440 gcacctgctg gcactgagag ctgtcttggg gaacacaggt gctcctgccg gagtcctcac 1500 gctctgctca cgttgcagaa ggccccctgg taaggccagc cagccggagg accaccccgc 1560 agaccacacg cccagggcct ggcaccgagg gggaggcccc gatcagcagg tgaaagcgac 1620 accctgatga cactggctag ttcaccttca ctctggtcat cgtttactgt accccggggc 1680 agctcccgcc tgagccc tat gaccccaacc gccgcagcct ctggtaaggc ctgggtatgg 1740 ggcacatgga gagggcccat tccagaggct cctaagtcaa aagagattcc acaagtcaaa 1800 atcctgatcc tgatcaagca caggccttca cagtgacatt tcactgtgac cctggcccag 1860 agacagagac cactgtcctg cagtgtccct gggagggagg ttctgggtct gccacaggac 1920 accacaccct ggaacattgc acaccctttg cctggccttt tcccagcgtt tctgtcagaa 1980 atgccccctc ccaagcatac accccatctt gtgccccgag ggactcgatt ctctccccac 2040 acacccgacc cgaggctgtc atgggtagtg cctgctgctg gccccagggt tagggctgct 2100 cagccagtcc tggctggaaa ggatgaatgt cccacaagca gctttggggc ctgcttggtg 2160 ggagcagccc gaggatccgc ccttcgtcct cctgccattt cccacttccc tggctctggg 2220 gtcctcatgt tcacgtggtt ctcagtgact gggtgattga cccccatgag ctgtcattat 2280 tttggtgtct tttgctggac atttaagcca ttccttgtgt ttctgccatt agctattatg 2340 ggctgtaaca tctttgcacc tgtgccttct ttctttttaa atttctgaag tcctaatttg 2400 acccaaaggt gacacatctc cctgtgtgcc ctgtcagtga tgaaacctgc tctggggatg 2460 aagatgccgt ggggcccaca gatccaagct ctcggagtgt gattctgtct cccctagaaa 2520 cacatccatg gcatgtcctc a gggcatttg tgcatgggat taagcaaatg tttcctaatc 2580 atgtttgtcc ctgtgctctg gcttcttgac ctcaggctgc ctcactggcc catcattaat 2640 acgtcgatgg tgagcgcact ggtgtacagc gagggggctc cacttccgag ccccctggag 2700 aggcccgtcc tggtggagtt caccctgctg gagatggaga agcgaaccaa gcctgtctgt 2760 gtgttctgga accattccct ggcgtaaatg tgatgccggg agttctgcat cttcatgtga 2820 gggctttgcc aagacacaga gaacccgcag ggttgttggc tcagcggcag atcgtcccac 2880 ggggacagtc tcttgtggtc tgtgtctccc ccttcagccc cctgtggggc agttag cct 2939 Pro 1 cct gct ctg ctt ctg tgg gtg cat cag agc ccc ccc aga tgc cca cac 2987 Pro Ala Leu Leu Leu Trp Val His Gln Ser Pro Pro Arg Cys Pro His 5 10 15 gca gac gcg cac agg cct gca cgt gga aac aca gac atg cgc aca cgc 3035 Ala Asp Ala His Arg Pro Ala Arg Gly Asn Thr Asp Met Arg Thr Arg 20 25 30 agg ccc aca cac aga cgc aca cag agc tgc acg tgg aga cac gtg cgc 3083 Arg Pro Thr His Arg Arg Thr Gln Ser Cys Thr Trp Arg His Val Arg 35 40 45 aca cgc agg ccc aca cgc agg ccc aca cac agg tgc acg cgg acc tgc 3131 Thr Arg Arg Pro Thr Arg Ar g Pro Thr His Arg Cys Thr Arg Thr Cys 50 55 60 65 acg tgg aga cac aga tgt gtg cac atg cag gcc cac aca cag gtg agc 3179 Thr Trp Arg His Arg Cys Val His Met Gln Ala His Thr Gln Val Ser 70 75 80 gtg gac ctg tgt gaa cag atg cgc gca gac ctg cac gtg gag aca cag 3227 Val Asp Leu Cys Glu Gln Met Arg Ala Asp Leu His Val Glu Thr Gln 85 90 95 aca tgc agg cgc aca aag aga tcc ctc aag gct gc gaa ggg 3275 Thr Cys Arg Arg Thr Lys Arg Ser Leu Lys Ala Asp Thr Gln Glu Gly 100 105 110 gcc tct cac ttg tgg gac tcc cga gat gca gtg gcc aac act agt gta 3323 Ala Ser His Leu Trp Asp Ser Arg Asp Ala Val Ala Asn Thr Ser Val 115 120 125 gtg ccc agt tca ctg ctg gat aag aca gag gcc tgt tct ggt cac aca 3371 Val Pro Ser Ser Leu Leu Asp Lys Thr Glu Ala Cys Ser Gly His Thr 130 135 140 145 tgg gag gca gaa ccc aga gac tgg gcc cag gag ccc ttc tgc 3413 Trp Glu Ala Glu Pro Arg Asp Trp Ala Gln Glu Pro Phe Cys 150 155 tgacagtggg aactcccagc tacgtgtggg ggtccccata ccagacaaag gtccctgacc 3473 ttagtctggc cc cc agctttgggg tctggcttta cccacaagag 3533 gccacacctt gccacagcac tgtttatctg gcctgtttca gaagcaccgt cagagtggcg 3593 aaggcaggag gtggtgcacg agagtctacg ttctagcatc cattcaagtg agggaaaggc 3653 gtttcgtact tagaaaaatg caaaattaat gattctcacc cacacatgag actgtggatt 3713 cacccatgta tgagacagtg gattcagagc catgctgtgg ctctcatctg ctgggagcca 3773 gtagtgtttg tgctttggtt ttgttttttt agctacatgg tttatgtgag gtgcggactt 3833 acttgagttg ctctgtcttt acagggagct tgctttttct ctgctggttt gttttcactt 3893 ttgctgtctc tgtttagaag aaaacattag aactggggtg tggtggaagg atgggagcac 3953 aatctgggag gggaagacct gctctctctc cacataccag gagggagtgg caggaagggg 4013 agacactgtg ccggactcag ggagtcaaga gcgtgagcac ccccaggctt caatctgctg 4073 aacgttgtgc atctgggggc gcccgtgcag caggaacact ctccccatca caattcctct 4133 gggcacagtg gagagccatg agtgggggct gtcctggggg ctgcgctatg gtgagtgagc 4193 ccacgccagg agccagttca gcccagcctc attcttctcc tgcttctttg ctttccaagt 4253 tctagttcat aagcaaccag cacagtacct ggaatgtaag aggcgcttgg cttataaaag 4313 agagaagaaa ggaacccctt tcaccacgag gg acgtcagg cccagctctc tgtcccgggc 4373 attcatcttt tttccggcaa ttagcttcag ctctaatgac ctgctgtctg ctttatgttg 4433 cacctatgat ttccagattg taaagtttgt ggcaaatgta ttaacgttca catcccattt 4493 acagattagc aaactaagga tctgagaggt tatgtgattt tcccagtctg gcggagggca 4553 gggccctgtc agaagccgag acacacctcg taacagcttg ttatttgggg cttcccatca 4613 gtgaggcagg agtcataatg gggccctggc ttctgggcaa ttcccataaa acattgtgcc 4673 acctgaagat ggaagtgtca gaggaaggcg agatgttatt tctgaaagca tctaccctca 4733 gaaagagaca gaggagtgca tcgcagctgt gtgaacccgg ggtggtggtg gttccagcag 4793 cggggcacgt ggtggacgca agacggcccc gtttgagttt tgctgctagg tgacacgtag 4853 aacttgaact tcagagggtg ctccttgggg gccctgatga gagagacaca gaagggaagg 4913 gagactgttc ccatggtcct gcctctgcgg cagcgagcct gctgctcttg cagctgggtg 4973 gctgttcggt gcagggggcc ggtgaggaac acggtgggga gcagcctgcg agggcgccgg 5033 gctttcagca ctcactatac ctgctgtttg gtttggccag gatggcctgg gagtccccag 5093 ggccgggcaa agactgcccc caacagacat gggcggaggg aaccgtctca cccctgcctc 5153 ttctcccttc tctacgcagt gtcagtggga cgggaggg tg gtctgcccgg ggcttcaagc 5213 tcctgtccag gaaccggacc catgtcgtac gccagtgcag ccacacggcc agcttcgagg 5273 tgctcatgga cgtctccagg tgtgagatgg gcatcttctt gtggccacta tgcccgctga 5333 gcctaccccc aaacctgccc ctcctcaaac taaatcttcc attctaagca ctttgaacga 5393 agcaaatcaa ccaattaaaa aaatatattc cagg 5427 <210> 166 <211> 5974 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2411) <400> 166 cg gac att cgt att cgg gtg gcc atc cca ctg gac tac gag acc gtg 47 Asp Ile Arg Ile Arg Val Ala Ile Pro Leu Asp Tyr Glu Thr Val 1 5 10 15 gac cgc tac gac ttt gat ctc ttt gcc aat gag agt gtg cct gac cat 95 Asp Arg Tyr Asp Phe Asp Leu Phe Ala Asn Glu Ser Val Pro Asp His 20 25 30 gtg ggc tat gcc aag gtg aag atc act ctc atc aat gaa aat gac aac 143 Val Gly Tyr Ala Lys Val Lys Ile Thr Leu Ile Asn Glu Asn Asp Asn 35 40 45 cgg ccc atc ttc agc cag cca ctg tac aac atc agc ctg tac gag aac 191 Arg Pro Ile Phe Ser Gln Pro Leu Tyr Asn Ile Ser Leu Tyr Glu Asn 50 55 60 gtc acc gtg ggg acc tct gtg ctg aca gtc ctg gca act gac aat gat 239 Val Thr Val Gly Thr Ser Val Leu Thr Val Leu Ala Thr Asp Asn Asp 65 70 75 gca ggc acc ttt ggg gaa gtc aac tac ttc ttc agt gat gac cct gac 287 Ala Gly Thr Phe Gly Glu Val Asn Tyr Phe Phe Ser Asp Asp Pro Asp 80 85 90 95 agg ttc tcg ctg gac aag gac acg gga ctc atc atg ctg att gcc agg 335 Arg Phe Ser Leu Asp Lys Asp Thr Gly Leu Ile Met Leu Ile Ala Arg 100 105 110 ctg gac tat gag ctc atc cag cgc ttc acc ctg acg atc att gcc cgg 383 Leu Asp Tyr Glu Leu Ile Gln Arg Phe Thr Leu Thr Ile Ile Ala Arg 115 120 125 gac ggg ggc ggc gag gag acc aca ggc cgg gtc agg atc ttg 431 Asp Gly Gly Gly Glu Glu Thr Thr Gly Arg Val Arg Ile Asn Val Leu 130 135 140 gat gtc aac gac aac gtg ccc acc ttc cag aag gat gcc tac gtg ggt 479 Asp Val Asn Asp Asn Val Pro Thr Phe Gln Lys Asp Ala Tyr Val Gly 145 150 155 gct ctg cgg gag aac gag cct tct gtc aca cag ctg gtg cgg ctc cgg 527 Ala Leu Arg Glu Asn Glu Pro Ser Val Thr Gln Leu Val Arg Leu Arg 160 165 170 175 gca aca gat gaa gac tcc cct ccc aac aac cag atc acc tac agc att 575 Ala Thr Asp Glu Asp Ser Pro Pro Asn Asn Gln Ile Thr Tyr Ser Ile 180 185 190 gtc agt gca tct gcc ttt ggc agc tac ttc gac atc agc ctg tac gag 623 Val Ser Ala Ser Ala Phe Gly Ser Tyr Phe Asp Ile Ser Leu Tyr Glu 195 200 205 ggc tat gga gtg atc agc gtc agt cgc ccc ctg gat tat gaa cag ata 671 Gly Tyr Gly Val Ile Ser Val Ser Arg Pro Leu Asp Tyr Glu Gln Ile 2 10 215 220 tcc aat ggg ctg att tat ctg acg gtc atg gcc atg gat gct ggc aac 719 Ser Asn Gly Leu Ile Tyr Leu Thr Val Met Ala Met Asp Ala Gly Asn 225 230 235 ccc cct ctc aac agc acc gtc cct gtc acc gag gtg ttt gat gag 767 Pro Pro Leu Asn Ser Thr Val Pro Val Thr Ile Glu Val Phe Asp Glu 240 245 250 255 aat gac aac cct ccc acc ttc agc aag ccc gcc tac ttc gtc tcc gtg 815 Asn Asp Asn As Pro Pro Thr Phe Ser Lys Pro Ala Tyr Phe Val Ser Val 260 265 270 gtg gag aac atc atg gca gga gcc acg gtg ctg ttc ctg aat gcc aca 863 Val Glu Asn Ile Met Ala Gly Ala Thr Val Leu Phe Leu Asn Ala Thr 275 280 285 gac ctg gac cgc tcc cgg gag tac ggc cag gag tcc atc atc tac tcc 911 Asp Leu Asp Arg Ser Arg Glu Tyr Gly Gln Glu Ser Ile Ile Tyr Ser 290 295 300 ttg gaa ggc tcc acc cag ttt cgg atc aat gcc cgc tca ggg 959 Leu Glu Gly Ser Thr Gln Phe Arg Ile Asn Ala Arg Ser Gly Glu Ile 305 310 315 acc acc acg tct ctg ctt gac cga gag acc aag tct gaa tac atc ctc 1007 Thr Thr Thr Ser Leu Leu Asp Arg Glu Thr Lys Ser GluTyr Ile Leu 320 325 330 335 atc gtt cgc gca gtg gac ggg ggt gtg ggc cac aac cag aaa act ggc 1055 Ile Val Arg Ala Val Asp Gly Gly Val Gly His Asn Gln Lys Thr Gly 340 345 350 atc gcc acc gta aac atc acc ctc ctg gac atc aac gac aac cac ccc 1103 Ile Ala Thr Val Asn Ile Thr Leu Leu Asp Ile Asn Asp Asn His Pro 355 360 365 acg tgg aag gac gca ccc tac tac atc aac ctg gtg gag atg acc cct 1151 Thr Trp Lys Asp Ala Pro Tyr Tyr Ile Asn Leu Val Glu Met Thr Pro 370 375 380 cca gac tct gac gtg acc acg gtg gtg gct gtt gac cca gac ctg ggg 1199 Pro Asp Ser Asp Val Thr Thr Val Val Ala Val Asp Pro Asp Leu Gly 385 390 395 gag aat ggc acc ctg gtg tac agc atc cag cca ccc aac aag ttc tac 1247 Glu Asn Gly Thr Leu Val Tyr Ser Ile Gln Pro Asn Lys Phe Tyr 400 405 410 415 agc ctc aac agc acc acg ggc aag atc cg acc cac gcc atg ctg 1295 Ser Leu Asn Ser Thr Thr Gly Lys Ile Arg Thr Thr His Ala Met Leu 420 425 430 gac cgg gag aac ccc gac ccc cat gag gcc gag ctg atg cgc aaa atc 1343 Asp Arg Glu Asn Pro Asp Pro H is Glu Ala Glu Leu Met Arg Lys Ile 435 440 445 gtc gtc tct gtt act gac tgt ggc agg ccc cct ctg aaa gcc acc agc 1391 Val Val Ser Val Thr Asp Cys Gly Arg Pro Pro Leu Lys Ala Thr Ser 450 455 460 agt gcc aca gtg ttt gtg aac ctc ttg gat ctc aat gac aat gac ccc 1439 Ser Ala Thr Val Phe Val Asn Leu Leu Asp Leu Asn Asp Asn Asp Pro 465 470 475 acc ttt cag aac ctg cct ttt gtg gcc gag gtg cttga g 1487 Thr Phe Gln Asn Leu Pro Phe Val Ala Glu Val Leu Glu Gly Ile Pro 480 485 490 495 gcg ggg gtc tcc atc tac caa gtg gtg gcc atc gac ctc gat gag ggc 1535 Ala Gly Val Ser Ile Tyr Gln Val Val Ala Ip Leu Asp Glu Gly 500 505 510 ctg aac ggc ctg gtg tcc tac cgc atg ccg gtg ggc atg ccc cgc atg 1583 Leu Asn Gly Leu Val Ser Tyr Arg Met Pro Val Gly Met Pro Arg Met 515 520 525 gac ttc ac atc ac atc ac atc ac atc ac atc ac atc ac at g agc ggc gtg gtg gtc acc acc acc gag 1631 Asp Phe Leu Ile Asn Ser Ser Ser Gly Val Val Val Thr Thr Glu 530 535 540 ctg gac cgc gag cgc atc gcg gag tac cag ctg cgg gtg gtg gcc agt 1679 Leu Asp Ar g Glu Arg Ile Ala Glu Tyr Gln Leu Arg Val Val Ala Ser 545 550 555 gat gca ggc acg ccc acc aag agc tcc acc agc acg ctc acc atc cat 1727 Asp Ala Gly Thr Pro Thr Lys Ser Ser Thr Ser Thr Leu Thr Ile His 560 565 570 575 gtg ctg gat gtg aac gac gag acg ccc acc ttc ttc ccg gcc gtg tac 1775 Val Leu Asp Val Asn Asp Glu Thr Pro Thr Phe Phe Pro Ala Val Tyr 580 585 590 aat gtg tct gtg tcc gag gacg gag ttc cgg gtg gtc tgg 1823 Asn Val Ser Val Ser Glu Asp Val Pro Arg Glu Phe Arg Val Val Trp 595 600 605 ctg aac tgc acg gac aac gac gtg ggc ctc aat gca gag ctc agc tac 1871 Leu Asn Asp Asp Asn Val Gly Leu Asn Ala Glu Leu Ser Tyr 610 615 620 ttc atc aca ggt ggc aac gtg gat ggg aag ttc agc gtg ggt tac cgc 1919 Phe Ile Thr Gly Gly Asn Val Asp Gly Lys Phe Ser Val Gly Tyr Arg 630 g 630 g gtt gtg aga acc gtg gtg ggc ctg gac cgg gag acc aca gcc 1967 Asp Ala Val Val Arg Thr Val Val Gly Leu Asp Arg Glu Thr Thr Ala 640 645 650 650 655 gcc tac atg ctc atc ctg gag gcc atc gac aac ggc cct gt a ggg aag 2015 Ala Tyr Met Leu Ile Leu Glu Ala Ile Asp Asn Gly Pro Val Gly Lys 660 665 670 cga cac acg ggc aca gcc acc gtg ttc gtc act gtc ctg gat gtg aat 2063 Arg His Thr Gly Thr Ala Thr Val Phe Val Thr Val Leu Asp Val Asn 675 680 685 gac aac cgg ccc atc ttt ctg cag agc agc tat gag gcc agc gtc cct 2111 Asp Asn Arg Pro Ile Phe Leu Gln Ser Ser Tyr Glu Ala Ser Val Pro 690 695 700 gag gac atc cct gaa ggc cac agc atc ttg cag gag gaa gac ttg gcc 2159 Glu Asp Ile Pro Glu Gly His Ser Ile Leu Gln Glu Glu Asp Leu Ala 705 710 715 tcc ccc tgc ata tct ccc gcc cca ccc aga agg gcc ttt cag Sergt ag Cys Ile Ser Pro Ala Pro Pro Arg Arg Ala Phe Gln Ser Ser 720 725 730 735 ggg gag aaa gag acg tca caa ttt ccc gga aag gag ttg aga aga gag 2255 Gly Glu Lys Glu Thr Ser Gln Phe Pro Gly Lys Glu Leu Arg Arg Glu 740 745 750 cca ggg ccc agc aag gcc cag aac aga gct gct ttc aca gag ccc ttg 2303 Pro Gly Pro Ser Lys Ala Gln Asn Arg Ala Ala Phe Thr Glu Pro Leu 755 760 765 gcc gag gct ccc ctc ttg ggagtaaa cag gca caa gaa gaa agg gct 2351 Ala Glu Ala Pro Leu Leu Gly Ser Lys Gln Ala Gln Glu Glu Arg Ala 770 775 780 cct ttg ccc agg gag cag gcg caa cag ctc caa ggc tca gag gga gag 2399 Pro Leu Pro Arg Ala Gln Gln Leu Gln Gly Ser Glu Gly Glu 785 790 795 aag gga gga ccc tgaaaacaat ttgggtgtgc acccacacct ctgcccagag 2451 Lys Gly Gly Pro 800 gcctcagttg ctgggtgggg agggaggccc ggagtgaatg agtctcttta ccaactatgg 2511 ggtttccgac tcggaggctg agccaaacag ggaatctggg cctgcccact ggggcaggct 2571 cccgggcttg ggagggacag aagcgtggga ggctggcaat gctcccctcc ctgcatcggg 2631 accaggaggc gggcaggaaa gggctgggga gcagggagct gactcccaga aacacagaga 2691 gcccagaaag ccctgaggat ttgcgagagt gtggtggcta gctccagaag gaggaagtag 2751 agggttctct cgatcagggc ctcagcttgt gaggacttgg agcatacccc cctggcctgg 2811 tgcctgaaac ccaattgaga gccctccccc tcctggactt ttccttcttc aggcctcagg 2871 gcagcctcaa cccccacccc aacctccagg aagacagtgc ctagtggcca gcagggcctg 2931 ctggtgaggt ggatggctac aggctgaatc cagcctagga tttgcaggga ggccccaggg 2991 gaagcaaacc aggaagagg t tactgagcag gaagggagga aggaacaaaa cccttaggga 3051 ggaggcctgc cccactttct aaacccaaag acttggtttc tatttacaca atactactct 3111 tactgaaatc ctagagccag cgagttaata tagggcagcc ctgagttctc ccatttctca 3171 gggagaaatg cagcgtctca ggatgacttc tccaaggtcc tcttggtaag tttcttgtga 3231 agccggactc actttttgag atcagattga cttggaagga agggacagtg ggcttctcca 3291 atagagcctg cttggagaga aatctttcta gagtcatctg agggaagatg aggctctgtg 3351 ttatgccagc ttccaccaag actcctgcct cagagggtgg ggacacaccc aggctgggcc 3411 acgcttcact ctgtacacag aagcctcata cttctgtgca cagaactggg gagtcaaagt 3471 gaggggctgg acaatgtctg gctctctgca agctcccaag ctggtaggaa agagaagaca 3531 tagacaaaaa ggacccatgc tgccaagaga atgttccttt tcctccccaa gagaggtagg 3591 agacagtagg ggcggctcca ggcaggaggg cttcacagag tgggtgtgtg tgaagcataa 3651 gccacagtta gtgggtgaca ggtctttcag ttttcctgga gttttggatc aagatgaggc 3711 tagaaagatt aattggagcc agctcccaga gggcactgca cactgcgctg aggagctttg 3771 gctatatcca tttggcatta gggagccagt gaaggttttg gagctgggga gtggcaagcc 3831 agagctcact ccttggggag acg tggctgg ctgcactgtg ggtcacagca ggatgggggt 3891 ggggcagctt tgtggtggga tcctggccag ctgactggga caggagctgg gcagcccagg 3951 tcctccctct gcccaccctt caaatttggg acctgaccaa agtgtttaac cctcgcgttg 4011 tgaggagagg tcaagggttt gggattctga gaagcccatc ctggggtggg actgctttga 4071 cgggtcatca gcaaagcact caccaaaacc acagatagca tccctagtgt gggcaggact 4131 tgggacccca cagctgtcct ggagaggtcc agaccatccc accctcgggg aggctgccgc 4191 tttccctggg tgaggtgtgg agctgctgtg agctgtcctc ctccgagtcc aggtggcatc 4251 acctccagct gctggaaatg ccctgcctct tgccactctg tcacagcacc cgccctggcc 4311 tctgaaggga gcctcctcga tcatcttcaa tcccttcctg attgatccca acgtgggtgc 4371 cctgaagagg ggccaccaag acggctgcca agaccatgct tggagagccc tgtttgctcc 4431 tcctcccagc tggcacccag gcatctgttc caccaggagg gaggcagctg ctcccacagg 4491 gcaccaggca gatgctggca gcacccggga aacccaagga agagagcccc gaggttttgc 4551 cccagcactg ggccagcaca gatgccagga cagtgtcttg gccccggtgt aggctgagca 4611 tttcacttga ctaaagggaa cctttgccat ttggcaactt ctccatgctg ggctttggca 4671 cctggagggc aaggcttctg tggcgagcg a gggtgctgct tctaggaggt ggttacgagc 4731 cccaggttgt accctgtgga gcctcaggcc aaaggcccag atgaccacga gtgcacatct 4791 cttgaccaga agtctttcat caagcagcag cgagggggtc tgcagagagg aaggtgctct 4851 tctgaggatc atctttggga aagggcgctg gcctgggcat gcaaggagct tcggggggtg 4911 agtgtgtgtc ccagactgct tgggccactg tcttcctgca gcctgcagca ccggtctctg 4971 aagcaggagg atctacaggt agacctaggg ggatgtgggg gcatgtttgt ggacacccca 5031 ttacatcttg gtagattcca tgtagtcaca gtggctgcgg ttgtcctcgg ggcccggcag 5091 gggctgtcga gggacggtgg gccggccatg gcggaagctg tgcagggaga ggcgcaagga 5151 gcccaggcgc ttccagagcc ggagctgggg ctcactgggg ctcccagggt ggtggggcat 5211 gcactcgtga gccctgcggc ggctcgggtc cagcgcggcc ggcttgcaga gcgtcatgaa 5271 cagcagacag gtggccagca ggaggaagat gcaggccagg gcgatgagca tggggagggg 5331 gtcagttgcc tctgcaaggg tcccgggagt gacgggagct gagagaaagg cgagggggct 5391 gatggctggg gagctggcga ggctggggcc ctctgtgctc atggctcctg caacagcaac 5451 aagacagaag ctcaaaggca gatcagctgg acccagggca gcgggtatag ggaagactta 5511 cctagggaat gtggatgggg gcaaggcact gtt aaactgg acagcatcat ggccacatca 5571 caggttaaga cagcaaggtc cagagacatc acaagtctaa gtgtacacac agctgagcag 5631 tgatggagct gggcccaagc tcaggccctc ttcctgttcc accctgtgcc catctgccat 5691 gcagacaaga gggcggtggc ctgtccgcat tttcaaatca atcctcatga atcatcacag 5751 ggtcttaggc ctggaaactt aagaccaact ctgtcaataa cttgctctgt ggccaggaac 5811 gagttatgga tggtaagagg ccgcagctgc cagggtccct agcagtaatc taataccaaa 5871 gctgcaaact gggggcccac gggtgtgttt agttgggtcc ttgccatgtt tttatcaatg 5931 taattatgaa tattttcaaa ataataacag atttcacaaa aat 5974 <210> 167 <211> 3558 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1668) <400> 167 gtg ctt cct tct aca gcc aat atg aaa agg cct aag tta aag aaa gca 48 Val Leu Pro Ser Thr Ala Asn Met Lys Arg Pro Lys Leu Lys Lys Ala 1 5 10 15 agt aaa cgc atg acc tgc cat aag cgg tat aaa atc caa aaa aag gtt 96 Ser Lys Arg Met Thr Cys His Lys Arg Tyr Lys Ile Gln Lys Lys Val 20 25 30 cga gaa cat cat cga aaa tta aga aag gag gct aaa aag cag ggt cac 144 Arg Glu His His Arg Lys Leu Arg Lys Glu Ala Lys Lys Gln Gly His 35 40 45 aag aag cct agg aaa gac cca gga gtt cca aac agt gct ccc ttt aag 192 Lys Lys Pro Arg Lys Asp Pro Gly Val Pro Asn Ser Ala Pro Phe Lys 50 55 60 gag gct ctt ctt agg gaa gct gag cta agg aaa cag agg ctt gaa gaa 240 Glu Ala Leu Leu Arg Glu Ala Glu Leu Arg Lys Gln Arg Leu Glu Glu 65 70 75 80 cta aaa cag cag cag aaa ctt gac agg cag aag gaa caga aag aaa 288 Leu Lys Gln Gln Gln Lys Leu Asp Arg Gln Lys Glu Leu Glu Lys Lys 85 90 95 aga aaa ctt gaa act aat cct gat att aag cca tca aat gtg gaa cct 336 Arg Lys Leu Glu Thr Asn Pro Asp Ile Lys Pro Ser Asn Val Glu Pro 100 105 1 10 atg gaa aag gag ttt ggg ctt tgc aaa act gag aac aaa gcc aag tcg 384 Met Glu Lys Glu Phe Gly Leu Cys Lys Thr Glu Asn Lys Ala Lys Ser 115 120 125 ggc aaa cag aat tca aag aag ctg tac tgc caaga aaa aag gtg 432 Gly Lys Gln Asn Ser Lys Lys Leu Tyr Cys Gln Glu Leu Lys Lys Val 130 135 140 att gaa gcc tcc gat gtt gtc cta gag gtg ttg gat gcc aga gat cct 480 Ile Glu Ala Ser Asp Val Val Leu Glu Val Leu Asp Ala Arg Asp Pro 145 150 155 160 ctt ggt tgc aga tgt cct cag gta gaa gag gcc att gtc cag agt gga 528 Leu Gly Cys Arg Cys Pro Gln Val Glu Glu Ala Ile Val Gln Ser Gly 165 170 175 cag aaa aag ctg gta ctt ata tta aat aaa tca gat ctg gta cca aag 576 Gln Lys Lys Leu Val Leu Ile Leu Asn Lys Ser Asp Leu Val Pro Lys 180 185 190 gag aat ttg gag agc tgg cta aat tat ttg aag aaa gaa ttg cca aca 624 Asn Leu Glu Ser Trp Leu Asn Tyr Leu Lys Lys Glu Leu Pro Thr 195 200 205 gtg gtg ttc aga gcc tca aca aaa cca aag gat aaa ggg aag ata acc 672 Val Val Phe Arg Ala Ser Thr Lys Pro Lys Asp Lys Gly Lys Ile T hr 210 215 220 aag cgt gtg aag gca aag aag aat gct gct cca ttc aga agt gaa gtc 720 Lys Arg Val Lys Ala Lys Lys Asn Ala Ala Pro Phe Arg Ser Glu Val 225 230 235 240 tgc ttt ggg aaa gag ggc ctt tgg aaa ctt ctt gga ggt ttt cag gaa 768 Cys Phe Gly Lys Glu Gly Leu Trp Lys Leu Leu Gly Gly Phe Gln Glu 245 250 255 act tgc agc aaa gcc att cgg gtt gga gta att ggt ttc cca aat gtg 816 Thr Cys Ser Lys A Arg Val Gly Val Ile Gly Phe Pro Asn Val 260 265 270 gg aaa agc agc att atc aat agc tta aaa caa gaa cag atg tgt aat 864 Gly Lys Ser Ser Ile Ile Asn Ser Leu Lys Gln Glu Gln Met Cys Asn 275 280 285 gtt ggt gta tcc atg ggg ctt aca agg agc atg caa gtt gtc ccc ttg 912 Val Gly Val Ser Met Gly Leu Thr Arg Ser Met Gln Val Val Pro Leu 290 295 300 gac aaa cag atc aca atc ata gat agt ccg agc ttc atc gtat cca 960 Asp Lys Gln Ile Thr Ile Ile Asp Ser Pro Ser Phe Ile Val Ser Pro 305 310 315 320 ctt aat tcc tcc tct gcg ctt gct ctg cga agt cca gca agt att gaa 1008 Leu Asn Ser Ser Ser Ala Leu Ala Leu Arg Se r Pro Ala Ser Ile Glu 325 330 335 gta gta aaa ccg atg gag gct gcc agt gcc atc ctt tcc cag gct gat 1056 Val Val Lys Pro Met Glu Ala Ala Ser Ala Ile Leu Ser Gln Ala Asp 340 345 350 gct cga cag gta gta ctg aaa tat act gtc cca ggc tac agg aat tct 1104 Ala Arg Gln Val Val Leu Lys Tyr Thr Val Pro Gly Tyr Arg Asn Ser 355 360 365 ctg gaa ttt ttt act atg ctt gct cag aga aga ggt atg cac caa aaa 1152 Leu Glu Phe Phe Thr Met Leu Ala Gln Arg Arg Gly Met His Gln Lys 370 375 380 ggt gga atc cca aat gtt gaa ggt gct gcc aaa ctg ctg tgg tct gag 1200 Gly Gly Ile Pro Asn Val Glu Gly Ala Ala Lys Leu Leu Trp Ser Glu 385 390 395 400 tgg aca ggt gcc tca tta gct tac tat tgc cat ccc cct aca tct tgg 1248 Trp Thr Gly Ala Ser Leu Ala Tyr Tyr Cys His Pro Pro Thr Ser Trp 405 410 415 act cct cct cca tat ttt aat gag agt att gtg gta gac atg aaa agc 1296 Thr Pro Pro Pro Tyr Phe Asn Glu Ser Ile Val Val Asp Met Lys Ser 420 425 430 ggc ttc aat ctg gaa gaa ctg gaa aag aac aat gca cag agc ata aga 1344 Gly Phe Aslu Glu Glu Leu Glu Lys Asn Asn Ala Gln Ser Ile Arg 435 440 445 gcc atc aag ggc cct cat ttg gcc aat agc atc ctt ttc cag tct tcc 1392 Ala Ile Lys Gly Pro His Leu Ala Asn Ser Ile Leu Phe Gln Ser Ser 450 455 460 ggt ctg aca aat gga ata ata gaa gaa aag gac ata cat gaa gaa ttg 1440 Gly Leu Thr Asn Gly Ile Ile Glu Glu Lys Asp Ile His Glu Glu Leu 465 470 475 480 cca aaa cgg aaa gaa agg aag cag gag gag ag aaa gac 1488 Pro Lys Arg Lys Glu Arg Lys Gln Glu Glu Arg Glu Asp Asp Lys Asp 485 490 495 agt gac cag gaa act gtt gat gaa gaa gtt gat gaa aac agc tca ggc 1536 Ser Asp Gln Glu Thr Val Asp Glu Val Glu Asn Ser Ser Gly 500 505 510 atg ttt gct gca gaa gag aca ggg gag gca ctg tct gag gag act aca 1584 Met Phe Ala Ala Gla Glu Glu Thr Gly Glu Ala Leu Ser Glu Glu Thr Thr 515 520 525 gca ggt gaa cag tct aca agg tct ttt atc ttg gat aaa atc att gaa 1632 Ala Gly Glu Gln Ser Thr Arg Ser Phe Ile Leu Asp Lys Ile Ile Glu 530 535 540 gag gat gat gct tat gac ttc agt aca gat tat gtg taacagaaca 1678 Glu Asp A sp Ala Tyr Asp Phe Ser Thr Asp Tyr Val 545 550 555 atggcttttt atgatttttt tttttaacat tttaagcaga ctgctaaact gttctctgta 1738 taagttatgg tatgcatgag ctgtgtaaat tttgtgaata tgtattatat taaaaccagg 1798 caacttggaa tccctaaatt ctgtaaaaag acaattcatc tcattgtgag tggaagtagt 1858 tatctggaat aaaaaaagaa gatacctatt gaaaaatgta agttttattt acagatcagg 1918 ccacaggtta caaaattaaa accaacagca gttttgaatt atctgtacca gctagctgaa 1978 ctagccatat cagttcttct ttccagtcat tcagcattgt agtaagaaaa cacttggtaa 2038 ggcagatgga gacatattta tagtctatag tctgtctggg aagctgactg ccagacaggg 2098 cagtttgtca tctttaccta gctgacacat ctttttccat ggcttgctac cgataggcat 2158 tgaagcctag caactgttac ttcccatgca tgctatcttc caggacttcc tgagaaatgc 2218 ttgcttacag ttcaaattct gtttcacttt atgtttgaga tctcggtata tcttcggatt 2278 aggttgaatt tgcctgttgg gtctggaata taccattttt cccaaacatc agtatatgaa 2338 gcagtccttc cccatggctt caaatgtcca ttccaatgga gtaacttggc agcctttaca 2398 aactgaggtg aatatcgttt tccagcactg gaaccttaca tttgagacaa aaatagccac 2458 atcgttgcgc catgtgaaat tgt gcagaaa acttacttaa gggaaacaaa gaatataccc 2518 catccctgag gatagttctt tagataccaa ttctttacta gcttatgcca ctggttaatt 2578 ctacttacca aggtggcgga cattccacat aggatcgatg gtagagtgct gttgataaaa 2638 tacgataagc agaggaggtg ttgtgatgct accagccagg gttctgctat acagtccctc 2698 tcttggtggg acagaaaaca aatgtttgtt agtgaaaagt actgactaac tcctgttagt 2758 caagactcta ggaattgaaa tacaacagtt tttcacagct aggccagtta catacttact 2818 ctacattgag tttcatccat ttttccagtt ggttagttat attctgtcgt ttccattccg 2878 tcaggtttgc aacaaaaact ccaggattaa atgagcaagt gctggctttc atggaaagct 2938 tacgaattct ttccttttta tagtcaagat agccaatgta attgtactaa aaacacaaat 2998 aggatatatg tacttactgc ttcaaacaaa atagatacaa ttttatagcc agtagagaga 3058 agagctgtta aactgacttc ttcagattag aaaataaata tttgaaattc caagttagaa 3118 taggaaccta gatgttgaca taataaacca gatgttcaag aacaattagg ctgtcaagtc 3178 catgaagaag tctacagaaa agcaggcttg agttttggga tgaaatgatt ggggagtgta 3238 aattgcagca aaagagttcc ctgaatttgc aacctcttcc cattaaacaa tattgtagga 3298 agaggggtgt ttggtaagca atttacctg g tttcctgctc cacggatgac aactttagta 3358 gaggctgaat cacaatcttc tgaaaatgca gctgcatgtc ctggcttcag tgctgtattg 3418 taaagggcaa gaatatcacc tgaaatagac aagatgttaa gatttacatt tccgttgcctact gg tctgcctc ctcg ctag ctag ctag gcctc gcctc gcctc gcctc gcctc gcctact <210> 168 <211> 5421 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (216) .. (3323) <400> 168 ccgaggagcc gtcgccgcca tttcaagacc gtactaggta gatggtcaat tagagttccc 60 agggtttgaa gcctgtaact gctgccgccg ctcaagccct ccagagcatt gctacggctg 120 ctgcccttgt actactacct ccaaatacgt tcttgctggt agtggcggca gcaggaccaa 180 ttacctcttt tttgctctcc ctcgagaagc tccag atg gcg tct tcc gtg ggc 233 Met Ala Ser Ser Val Gly 1 5 aac gtg gcc gac agc aca ggg tta gct gag ttg gca cat cga gaa tat 281 Asn Val Ala Asp Ser Thr Gly Leu Ala Glu Leu Ala His Arg Glu Tyr 10 15 20 cag gca gga gat ttt gag gca gct gag aga cac tgc atg cag ctc tgg 329 Gln Ala Gly Asp Phe Glu Ala Ala Glu Arg His Cys Met Gln Leu Trp 25 30 35 aga caa gag cca gac aat act ggt gtg ctt tta tta ctt tca tct ata 377 Arg Gln Glu Pro Asp Asn Thr Gly Val Leu Leu Leu Leu Ser Ser Ile 40 45 50 cac ttc cag tgt cga agg ctg gac aga tct gct cac ttt agc act ctg 425 His Phe Gln Cys Arg Arg Leu Asp Arg Ser Ala His Phe Ser Thr Leu 55 60 65 70 gca att aaa cag aac ccc ctt ctg gca gaa gct tat tcg aat ttg ggg 473 Ala Ile Lys Gln Asn Pro Leu Leu Ala Glu Ala Tyr Ser Asn Leu Gly 75 80 85 aat gtg tac aag gaa aga ggg cag ttg cag gag gca att gag cat tat 521 Asn Val Tyr Lys Glu Arg Gly Gln Leu Gln Glu Ala Ile Glu His Tyr 90 95 100 cga cat gca ttg cgt ctc aaa cct gat ttc atc gat ggt tat att aac 569 Arg His Ala Leu Arg Leu Lys Pro Asp Phe Ile Asp Gly Tyr Ile Asn 105 110 115 ctg gca gcc gcc ttg gta gca gcg ggt gac atg gaa ggg gca gta caa 617 Leu Ala Ala Ala Val Ala Ala Gly Asp Met Glu Gly Ala Val Gln 120 125 130 gct tac gtc tct gct ctt cag tac aat cct gat ttg tac tgt gtt cgc 665 Ala Tyr Val Ser Ala Leu Gln Tyr Asn Pro Asp Leu Tyr Cys Val Arg 135 140 145 150 agt gac ctg ggg aac ctg ctc aaa gcc ctg ggt cgc ttg gaa gaa gcc 713 Ser Asp Leu Gly Asn Leu Leu Lys Ala Leu Gly Arg Leu Glu Glu Ala 155 160 165 aag gca tgt tat ttg aaa gca attag aaa gca atg ttt gca gta 761 Lys Ala Cys Tyr Leu Lys Ala Ile Glu Thr Gln Pro Asn Phe Ala Val 170 175 180 gct tgg agt aat ctt ggc tgt gtt ttc aat gca caa ggg gaa att tgg 809 Ala Trp Ser Asn Leu Gly Cys Val Phe Asn Ala Gln Gly Glu Ile Trp 185 190 195 ctt gca att cat cac ttt gaa aag gct gtc acc ctt gac cca aac ttt 857 Leu Ala Ile His His Phe Glu Lys Ala Val Thr Leu Asp Pro Asn Phe 200 205 210 ctg gat gct tat atc aat tta gga aat gtc ttg aaa gag gca cgc att 905 Leu Asp Ala Tyr Ile Asn Leu Gly Asn Val Leu Lys Glu Ala Arg Ile 215 220 225 230 ttt gac aga gct gtg gca gct tat ctt cgt gcc cta agt ttg agt cca 95 Arg Ala Val Ala Ala Tyr Leu Arg Ala Leu Ser Leu Ser Pro 235 240 245 aat cac gca gtg gtg cac ggc aac ctg gct tgt gta tac tat gag caa 1001 Asn His Ala Val Val His Gly Asn Leu Ala Cys Val Tyr Tyr Glu Gln 250 255 260 ggc ctg ata gat ctg gca ata gac acc tac agg cgg gct atc gaa cta 1049 Gly Leu Ile Asp Leu Ala Ile Asp Thr Tyr Arg Arg Ala Ile Glu Leu 265 270 275 275 caa cca cat ttc cct gat gct tac tgc ac gcc aat gct ctc aaa 1097 Gln Pro His Phe Pro Asp Ala Tyr Cys Asn Leu Ala Asn Ala Leu Lys 280 285 290 gag aag ggc agt gtt gct gaa gca gaa gat tgt tat aat aca gct ctc 1145 Glu Lys Gly Ser Val Ala Gl u Ala Glu Asp Cys Tyr Asn Thr Ala Leu 295 300 305 310 cgt ctg tgt ccc acc cat gca gac tct ctg aat aac cta gcc aat atc 1193 Arg Leu Cys Pro Thr His Ala Asp Ser Leu Asn Asn Leu Ala Asn Ile 315 320 325 aaa cga gaa cag gga aac att gaa gag gca gtt cgc ttg tat cgt aaa 1241 Lys Arg Glu Gln Gly Asn Ile Glu Glu Ala Val Arg Leu Tyr Arg Lys 330 335 340 gca tta gaa gtc ttc cca gag ttt gct gct tta gca 1289 Ala Leu Glu Val Phe Pro Glu Phe Ala Ala Ala His Ser Asn Leu Ala 345 350 355 agt gta ctg cag cag cag gga aaa ctg cag gaa gct ctg atg cat tat 1337 Ser Val Leu Gln Gln Gln Gly Lys Leu Gln Glu Ala Leu Met His Tyr 360 365 370 aag gag gct att cga atc agt cct acc ttt gct gat gcc tac tct aat 1385 Lys Glu Ala Ile Arg Ile Ser Pro Thr Phe Ala Asp Ala Tyr Ser Asn 375 380 385 390 atg gga aac act cta aag gag atg cag gat gtt cag gga gcc ttg cag 1433 Met Gly Asn Thr Leu Lys Glu Met Gln Asp Val Gln Gly Ala Leu Gln 395 400 405 tgt tat acg cgt gcc atc caa att aat cct gca ttt gca gat gca cat 1481 Cy s Tyr Thr Arg Ala Ile Gln Ile Asn Pro Ala Phe Ala Asp Ala His 410 415 420 agc aat ctg gct tcc att cat aag gat tca ggg aat att cca gaa gcc 1529 Ser Asn Leu Ala Ser Ile His Lys Asp Ser Gly Asn Ile Pro Glu Ala 425 430 435 ata gct tct tac cgc acg gct ctg aaa ctt aag cct gat ttt cct gat 1577 Ile Ala Ser Tyr Arg Thr Ala Leu Lys Leu Lys Pro Asp Phe Pro Asp 440 445 450 gct tat tgt aac ttg gct cat tgc cag att gtc tgt gat tgg aca 1625 Ala Tyr Cys Asn Leu Ala His Cys Leu Gln Ile Val Cys Asp Trp Thr 455 460 465 470 gac tat gat gag cga atg aag aag ttg gtc agt att gtg gct gac cag 1673 Asp Tyr Asp Gyr Met Lys Lys Leu Val Ser Ile Val Ala Asp Gln 475 480 485 tta gag aag aat agg ttg cct tct gtg cat cct cat cat agt atg cta 1721 Leu Glu Lys Asn Arg Leu Pro Ser Val His Pro His His Ser Met Leu 490 495 500 tat cct ctt tct cat ggc ttc agg aag gct att gct gag agg cac ggc 1769 Tyr Pro Leu Ser His Gly Phe Arg Lys Ala Ile Ala Glu Arg His Gly 505 510 515 aac ctg tgc tta gat aag att aat gtt ctt cat aaaca cca tat gaa 1817 Asn Leu Cys Leu Asp Lys Ile Asn Val Leu His Lys Pro Pro Tyr Glu 520 525 530 cat cca aaa gac ttg aag ctc agt gat ggt cgg ctg cgt gta gga tat 1865 His Pro Lys Asp Leu Lys Leu Ser Asp Gly Arg Leu Arg Val Gly Tyr 535 540 545 550 gtg agt tcc gac ttt ggg aat cat cct act tct cac ctt atg cag tct 1913 Val Ser Ser Asp Phe Gly Asn His Pro Thr Ser His Leu Met Gln Ser 555 560 565 att cca ggc atg cac aat cct gat aaa ttt gag gtg ttc tgt tat gcc 1961 Ile Pro Gly Met His Asn Pro Asp Lys Phe Glu Val Phe Cys Tyr Ala 570 575 580 ctg agc cca gac gat ggc aca aac ttc cga gtg aag gtg atgca 2009 Ser Pro Asp Asp Gly Thr Asn Phe Arg Val Lys Val Met Ala Glu 585 590 595 gcc aat cat ttc att gat ctt tct cag att cca tgc aat gga aaa gca 2057 Ala Asn His Phe Ile Asp Leu Ser Gln Ile Pro Cys Asn Gly Lys Ala 600 605 610 gct gat cgc atc cat cag gat gga att cat atc ctt gta aat atg aat 2105 Ala Asp Arg Ile His Gln Asp Gly Ile His Ile Leu Val Asn Met Asn 615 620 625 630 630 ggc tat act aag ggc gct cga aat gag ctt ttt gct ctc agg cca gct 2153 Gly Tyr Thr Lys Gly Ala Arg Asn Glu Leu Phe Ala Leu Arg Pro Ala 635 640 645 cct att cag gca atg tgg ctg gga tac cct ggg acg agt ggt gcg ctt 2201 Pro Ile Gln Met Trp Leu Gly Tyr Pro Gly Thr Ser Gly Ala Leu 650 655 660 ttc atg gat tat att atc act gat cag gaa act tcg cca gct gaa gtt 2249 Phe Met Asp Tyr Ile Ile Thr Asp Gln Glu Thr Ser Pro Ala Glu Val 665 670 675 gct gag cag tat tcc gag aaa ttg gct tat atg ccc cac act ttt ttt 2297 Ala Glu Gln Tyr Ser Glu Lys Leu Ala Tyr Met Pro His Thr Phe Phe 680 685 690 att ggt gat cat gct aat atg ttc cct cac ctg aagaaa aaa gca gtc 2345 Ile Gly Asp His Ala Asn Met Phe Pro His Leu Lys Lys Lys Ala Val 695 700 705 710 atc gat ttt aag tcc aat ggg cac att tat gac aat cgg ata gtt ctg 2393 Ile Asp Phe Lys Ser Asn Gly His Ile Tyr Asp Asn Arg Ile Val Leu 715 720 725 aat ggc atc gac ctc aaa gca ttt ctt gat agt cta cca gat gtg aaa 2441 Asn Gly Ile Asp Leu Lys Ala Phe Leu Asp Ser Leu Pro Asp Val Lys 730 735 740 att gtc a ag atg aag tgt cct gat gga gga gac aat gca gat agc agt 2489 Ile Val Lys Met Lys Cys Pro Asp Gly Gly Asp Asn Ala Asp Ser Ser 745 750 755 aac aca gct ctt aat atg cct gtt att cct atg aat act att gca gaa 2537 Asn Thr Ala Leu Asn Met Pro Val Ile Pro Met Asn Thr Ile Ala Glu 760 765 770 gca gtt att gaa atg att aac cga gga cag att caa ata aca att aat 2585 Ala Val Ile Glu Met Ile Asn Arg Gly Gln Ile Gln Ile Thr Ile Asn 775 780 785 790 gga ttc agt att agc aat gga ctg gca act act cag atc aac aat aag 2633 Gly Phe Ser Ile Ser Asn Gly Leu Ala Thr Thr Gln Ile Asn Asn Lys 795 800 805 gct gca act gga gag gag gtt ccc cgt acc att att gta acc acc cgt 2681 Ala Ala Thr Gly Glu Glu Val Pro Arg Thr Ile Ile Val Thr Thr Arg 810 815 820 tct cag tac ggg tta cca gaa gat gcc atc gta tac tgt aac ttt aat 2729 Ser Gln Tyr Gly Leu Pro Glu Asp Ala Ile Val Tyr Cys Asn Phe Asn 825 830 835 cag ttg tat aaa att gac cct tct act ttg cag atg tgg gca aac att 2777 Gln Leu Tyr Lys Ile Asp Pro Ser Thr Leu Gln Met Trp Ala Asn Ile 840 845 850 ctg aag cgt gtt ccc aat agt gta ctc tgg ctg ttg cgt ttt cca gca 2825 Leu Lys Arg Val Pro Asn Ser Val Leu Trp Leu Leu Arg Phe Pro Ala 855 860 865 870 870 gta gga gaa cct aat att caa cag caa aac atg ggc ctg ccc 2873 Val Gly Glu Pro Asn Ile Gln Gln Tyr Ala Gln Asn Met Gly Leu Pro 875 880 885 cag aac cgt atc att ttt tca cct gtt gct cct aaa gag gaa cac gtc 2921 Gln Asn Arg Ile Ple Pro Val Ala Pro Lys Glu Glu His Val 890 895 900 agg aga ggc cag ctg gct gat gtc tgc ttg gac act cca ctc tgt aat 2969 Arg Arg Gly Gln Leu Ala Asp Val Cys Leu Asp Thr Pro Leu Cys Asn 905 910 910 ggg cac acc aca ggg atg gat gtc ctc tgg gca ggg acc ccc atg gtg 3017 Gly His Thr Thr Gly Met Asp Val Leu Trp Ala Gly Thr Pro Met Val 920 925 930 act atg cca gga gag act ctt gct tct cga gtt gca gca tcc cag ctc 3065 Thr Met Pro Gly Glu Thr Leu Ala Ser Arg Val Ala Ala Ser Gln Leu 935 940 945 950 act tgc tta ggt tgt ctt gag ctt att gct aaa aac aga caa gaa tat 3113 Thr Cys Leu Gly Cys Leu Glu Leu Ile Ala L ys Asn Arg Gln Glu Tyr 955 960 965 gaa gac ata gct gtg aag ctg gga act gat cta gaa tat ctg aag aaa 3161 Glu Asp Ile Ala Val Lys Leu Gly Thr Asp Leu Glu Tyr Leu Lys Lys 970 975 980 ctt cgt gtcgt gtcgg tgg aag caa aga ata tct agc cct ctg ttc aac 3209 Val Arg Gly Lys Val Trp Lys Gln Arg Ile Ser Ser Pro Leu Phe Asn 985 990 995 acc aaa caa tac aca atg gaa cta gag cgg ctc tat cta cag atg tgg 3257 Lys Gln Tyr Thr Met Glu Leu Glu Arg Leu Tyr Leu Gln Met Trp 1000 1005 1010 gag cat tat gca gct ggc aac aaa cct gac cac atg att aag cct gtt 3305 Glu His Tyr Ala Ala Gly Asn Lys Pro Asp His Met Ile Lys Pro Val 1015 1020 1025 1030 gaa gtc act gag tca gca taaataaaga ctgcacagga gaattacccc 3353 Glu Val Thr Glu Ser Ala 1035 tatacctgag cctcaacctt ctgggggaaa gggaactaga taacatactt cttacttgtc 3413 tgtacagtac cttgttgcag atgggtgata tataatggta atagaatagc acagccagac 3473 ttgcttcctg catggtaggg agagacacaa aagatgggaa actgcttttc cacaaggaat 3533 ctccgtagaa ttttgcggcg accagatggt gcataggtct ggaaggtctg atctcccttg 3593 gtcttccatg ggatggttag tgtggagggg agatatagat tgtccggccg ctttgtgatt 3653 ccatggattg attcagtctt ctggattttt ttttctttat attttgggta ctggagcttt 3713 taaaaatgtt tggtttcagg tatttttatt catgtgaagt gtatatgatt ctcttgagat 3773 aaggttttaa gctaaaatgt tactccctgt tttagtttct gaactctgac agattgacag 3833 ggactttgct ggtgtagtct ttttataggt tttataaacc acttgagcct atatcagtcg 3893 ttttagtgtc tgacctaata tttggagcta tcagtgcttt gttgatttag atgatgactc 3953 aagatttttt ctggtccatt tcccatttcc ttttcttccc tgacccccat accctcaccc 4013 ttaaaattct cctgtaactc aactaacaaa atcaagcctg attcaaaaca tcctagggtg 4073 ttttaaacac accatctggt gccaaatgaa gatttttagg agtgattact aattatcaag 4133 ggcacagttg tggtactgtc attgataata atatagtttt tttttttttc ctaattttga 4193 cctgtttcac cagtgtttta cccttgactg ccccttctat gctgcttcca aaagtgatag 4253 tgtgtgtaag atttttacct tcctttctaa agtttttttt ttttttttta agtgagtcct 4313 gttcttccta tttctttcag cagaaatgaa atcccaggta agtataagta ttcaagtatt 4373 tgatcagtaa gtcacagtta tctccagtgc attaaataac cttcatcaag aaataggtta 4433 tagg taaaat ctctgaagga tcatctatgt attcaagtaa ttatttttta gataataact 4493 gtcttctgga cttggtcttg aagtctgtac agattcagcc tcagtagtag cgaactgcac 4553 tgctgtttgg tttggagtac aaattagact tatagtcctc ctggaacttg agttattaaa 4613 atcataggaa taaaattatg ggatctcaac aaagggtcga gggtttgagg cttaaacaag 4673 ccaacatatg aatatatgtt ttgtctcgct atactgcact tacgctatcc agttgcaggt 4733 aattttttgt ctgctagtag tgttctagat tatgtctttc caaagcgctg aggctgtgca 4793 cctattctgt agttgcagct gatgcctgaa tgtatcctag ctgacaaatt attgattaat 4853 aagaacttga atttctggaa gattcttact gttaaccaaa ttttgagcaa ggagtctcaa 4913 aggtaattct gaaccagaat tacatgttaa tgaacagtgt accttttaac agtgtaaatc 4973 acggaatatc cgtgaaggga tttcttaatt tattttttac cggttgattg aaatatcagt 5033 taaaggttgc cagcatggtt gcagataaac tgatgtttga aattcgctga aatacttaat 5093 gtggaatagg ataatatact tccaatgccc tcaaggctgt gaccttacag ccattttaca 5153 tagcacatca ttcctcctat agggatgaac tttttcctgg cacgaaaagt agccgctctg 5213 gttgaagctt tgcttattgt aacaggcttt tatttccagg taatatgtct tggaagactt 5273 aattctgatt agagatatag atattactgg aaactaattg ttttttttct attgtactct 5333 gctttatcaa agaagtaaaa catttaaatc gtactacaga aattaagatg ttgtcttgcg 5393 atccttaata aatgaatgat ttcccttt 5421 <210> 169 <211> 5348 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (858) .. (1832) <400> 169 gcggccgcct acctgcagca tctgtgcttt gagaacgagg gtgtcaagcg gcgtgtacgg 60 cagttgcggg ggctgccgct gcttgtggca ctgctggacc acccgcgggc tgaggtgcgg 120 cgccgggcct gtggggcact gcgcaacctc tcctatggcc gcgacactga caacaaggcc 180 gccatccggg actgcggtgg tgtgcctgcc ctggtgcgcc tgctgagggc tgcccgggac 240 aacgaggtcc gtgagcttgt cactggtgag tgggacctgg ccatgctcac atcccctggg 300 aagagaagag tgtgaggctc aacccgggag gaacgaggcc actcggcctg cgaccgcctg 360 ggaaagcacc cggtaggcag gagtgcagct gctgagacgc ttgccccagg agccaggcat 420 caggcccaga cactgtgaca ggttccccag tctctaccat agtagggagg ctgacgctgc 480 gcccctcggg catgtcccct cacctcctgc cttcacacct cctgccccca cagaaactct 540 cctgggaccc acctccttgg ttcccacccc aaccgtgcag tggtggggct tgtgccttgt 600 gagagctgag ggacaggtag ggtcaccgtg tctctgtgag gccctgtggc ctcaggagtg 660 ttagtgccac ctgccacatg gcagggaatg ggtgggacgg gacagcactg ccacaccctc 720 ctctgcacct cctccccttt ggggctcctt cctagctgga aaccagtact gggtgtcccc 780 cggaaccact cacggctttt gttacttcct actgttctgc atgagctggg acatgaggag 840 agtgggacag gtcctga gcg tgg cca cct ggg gag gta ggc agg cgg tgc 890 Ala Trp Pro Pro Gly Glu Val Gly Arg Arg Cys 1 5 10 ata tgg tca gca cag att ggc caa tcg cac ccc aca ggc acc ctg tgg 938 IleTrp Ala Gly Gln Ser His Pro Thr Gly Thr Leu Trp 15 20 25 aac ctg tca tcc tat gag ccc ctg aag atg gtc atc att gac cat ggc 986 Asn Leu Ser Ser Tyr Glu Pro Leu Lys Met Val Ile Ile Asp His Gly 30 35 40 ctg cag acg ctg acc cac gag gtg atc gtg ccc cac tca gga tgg gag 1034 Leu Gln Thr Leu Thr His Glu Val Ile Val Pro His Ser Gly Trp Glu 45 50 55 cgt gag ccc aac gag gac tcc aag cca cgg gac gcc gag tgg aca act 1082 Arg Glu Pro Asn Glu Asp Ser Lys Pro Arg Asp Ala Glu Trp Thr Thr 60 65 70 75 gtc ttc aag aac acg tcg ggc tgc ctg agg aat gtg agc tcc gat ggt 1130 Val Phe Lys Asn Thr Ser Gly Cys Leu Arg Asn Val Ser Ser Asp Gly 80 85 90 gct gag gcc cgg cgg cga ctc cgg gag tgt gaa ggg ctg gtg gac gcg 1178 Ala Glu Ala Arg Arg Arg Leu Arg Glu Cys Glu Gly Leu Val Asp Ala 95 100 105 ctc ctg cat gcc ctg cag tcg gct gtg g gc cgg aag gac act gac aac 1226 Leu Leu His Ala Leu Gln Ser Ala Val Gly Arg Lys Asp Thr Asp Asn 110 115 120 aag tcg gtg gag aac tgc gtg tgc atc atg cgg aac ctg tcc tac cac 1274 Lys Ser Val Glu Asn Cys Val Cys Ile Met Arg Asn Leu Ser Tyr His 125 130 135 gtg cac aag gag gtg ccc ggg gcc gac agg tac cag gag gcc gag ccc 1322 Val His Lys Glu Val Pro Gly Ala Asp Arg Tyr Gln Glu Ala Glu Pro 140 145 150 155 ggg ccc ctg ggc agt gct gta ggc tcc cag cgc cgg agg cgg gat gat 1370 Gly Pro Leu Gly Ser Ala Val Gly Ser Gln Arg Arg Arg Arg Asp Asp 160 165 170 gcc agc tgc ttt gga ggc aag aag gcc ggggg gga ctg 1418 Ala Ser Cys Phe Gly Gly Lys Lys Ala Lys Gly Gly Trp Gly Gly Leu 175 180 185 ggg tat cat ctc tac cat ctc aac tcc tgc ccc agc gga agg ctc tct 1466 Gly Tyr His Leu Tyr His Leu Asn Ser Cys Ser Gly Arg Leu Ser 190 195 200 gta cac cca cag cag ccc atc atg gag gct aga gga cac ctg gtc agc 1514 Val His Pro Gln Gln Pro Ile Met Glu Ala Arg Gly His Leu Val Ser 205 210 215 ccc caa cag gca g gc agg gaa gcc agg agt caa gga ggc tgg act gcc 1562 Pro Gln Gln Ala Gly Arg Glu Ala Arg Ser Gln Gly Gly Trp Thr Ala 220 225 230 235 ctg ggt cac atg gtt gat ggg acc cag gtc caa cct tcc cca tct aca10 Leu Gly His Met Val Asp Gly Thr Gln Val Gln Pro Ser Pro Ser Thr 240 245 250 ctg tgg gac ccc cag gga gta cac aag gga aac caa cca atg ccc aga 1658 Leu Trp Asp Pro Gln Gly Val His Lys Gly Asn Gln Pro Met Pro Arg 255 260 265 ccc agt ctt tct act ccg ggg aga gtt cca ctt gcc cat gag ttg gga 1706 Pro Ser Leu Ser Thr Pro Gly Arg Val Pro Leu Ala His Glu Leu Gly 270 275 280 agg agc cat ggc tgc tgc ctg ctc act gtt cac aga ata gct gta gac 1754 Arg Ser His Gly Cys Cys Leu Leu Thr Val His Arg Ile Ala Val Asp 285 290 295 tgc cac caa cct gtg ggg cag ccc cca tct gcc tgg gca aga tgc cct 1802 Cys His Gln Pro Val Gly Gln Pro Pro Ser Ala Trp Ala Arg Cys Pro 300 305 310 315 gca cac ctt ctc tac tgc act agc agg gtg taggttccca ggacctcccc 1852 Ala His Leu Leu Tyr Cys Thr Ser Arg Val 320 325 agcagctgtg ggggacctgt a cgccacctg cccctgcccc actgacccca ggcctccctc 1912 ttcttgtccc cctggtgggt gctcagtgcc cagaagtgat gggatgaggt tccacatgct 1972 gcctgcttga tccagggtgt gcagtgggaa cctgaggctt ccgggagggc atgggggggt 2032 gatgagtgct gcctgttcag gctcctctcc tctctcctct gcttcctccg gcctcccaga 2092 ggagtggttc caccaaggtg agtccctttt tatcctgctc tccaggcctg gcgtgtgcag 2152 tgggtacctg ggaagaggcg agcacgttcc agccccaggg ccctgcccca cccctggctt 2212 catcactcgg gctgccatct ttatgacagt ggcaggtggg aaggccacgg ggctcattct 2272 gtaacctcag acttgcctac ctgggcagag ttgggcagag ccaagagtgg gcagggcccg 2332 ggggtactta tctctagggg caccaaggag cagtctgttt ctctgataga atggggcatc 2392 atgtggctcg gagggataca agggtcccat gagggtgagc agggcaggga ccccaggtca 2452 tctggctcca ctctgctgcc ttctgaaggg gtagaagcat catctgacat ggggagagtg 2512 gttgacagtg ggctcactgt cacagacgtg tgcaagccag ggctacacaa atgttaggtg 2572 ggctgctgtg gggtttctcc tggctagtag atcctgggac aatgtcctga ccccagctgg 2632 gggagtttcc ccctagttct gccttactgt gtgacccaaa tgagtcttgt cctggtcagc 2692 cttcagtttc ttggcttgta tccacct acc atccagccag ggctcctggc ttccctcagt 2752 ctacatacct ggcagttgca agggagccac cgggagggtc tgtggtacag ctcccagcac 2812 ctggtgggag atgagtccta ggggcagggc tgggacatcc ccaggcccca ctgccaccaa 2872 ctcctacccc taggctaaac tgtctgccca aactctgaca acggtgctcc actcccacag 2932 gtgcccaggc ctggacatgg gggtgccttt tggggcctgg gtaggagaga actgtgccca 2992 actctcctga tacacccatt ccccatatgg ggtctgcctc acctcccacc acctttccct 3052 tccaggaaag aaggatggtg agatggaccg gaactttgac acgctagacc tgcccaagcg 3112 aactgaggcc gccaaaggct ttgagctgct gtaccagccc gaggtggtac gtctctacct 3172 ctccctcctc acggagagcc ggaacttcaa caccctggag gctgccgccg gcgctctgca 3232 gaacctcagt gccggcaact ggatgtgggc cacgtacatc cgcgccacag tgcgcaaaga 3292 gcgcgggctg ccggtgcttg tggaactgct gcagtctgag accgacaagg tggtgcgcgc 3352 cgtcgccatc gctctgcgca acctctcgct ggaccggcgc aacaaagacc tcatcgggag 3412 ctacgccatg gctgagcttg tgcggaatgt gcgcaatgca caggctccgc cgcgaccggg 3472 ggcctgcctg gaggaagaca ccgtggtggc ggtgctcaac accatccacg aaatcgtgtc 3532 cgacagcctg gataacgcgc gctcgctcct g catgggcca gagcctgtga gctagtgtgt 3592 gtgcaccctt ctgtgcatgt gcgtgtgaga gcccaccagg gtccaccagc gatggcagga 3652 cctgctgcct gctgtgtgcc aatcccctgg cttcctgtgc aggcctgtgt gtgtgcacgt 3712 gcccgccctg ggcccgtgtg agccacacgt ttccggctcc ctgcgccctt ggtgctacct 3772 gtgctgtcct ggcaggccaa cccttacatc gccagcctcg gccctgcccc tgccctgtcc 3832 ccccaggagc tctaactaac ctgctctatt gtgcctctaa tgcccacccg tgcgctgcag 3892 ctcgacccca gcaggaaggc ccctcccccc gggcccagca ggcccgcggt caggctggtg 3952 gacgccgtag gggacgctaa gcctcagccc gttgattcct gggtctagct tgcatgcctg 4012 gtacgttctc tcatctggtt gttcgtccac ctgttcctgc cctctgggcc agggcttctt 4072 gttagtctcc gctgcctgca cgctctgctc ttcccgcacg ttccccgcag gactttggcc 4132 tccagtccag cagcccagtg gcccattccc ggaaagacca ggcagaggtc agagagggag 4192 ggtgctccct gggcccacag ccctgtccca ggcactgtgg gatcaggggc ctgaggaaat 4252 gggaccagag tagggatggg caccataccc tccaacgccc ttcggggacc agcaagtcag 4312 gatcagccct ggtgccaaga cccttggggt cagcccacac cacccagggc agatgcttct 4372 atccacatct ccatccatgt agcctgtgga gttggct gcc ctgccctgag gttacacgtg 4432 gtcctgtgcc actcagtggc tgcagcgtcc accatcccct ttccctctgc agggcccagg 4492 cccagcctct tgttcttagg gcttggatcg tggaagaagg gccaccctga gcagatcgtg 4552 ccgtggagct tggagccccc tggcggcagg ggttggcagc gcctcgcccc agccaagcct 4612 gactttgggg acaccctcct gcccccccac cccactcccc ccatcctacc taactcccta 4672 ggcctgagtt agctgtttac tgacatggtg ctgtgtgtga gcgagtgaca gaaggcccga 4732 ggaggccgac tgggctgctg gggcagggcc cagggaggtg gcagggaagg gtgcctggct 4792 gggctttggg gctggtggga taggagggtg cccctgggaa cacagtgccc cagtggtgcg 4852 ggccaggtct ggcgccaggg gcaggcagct aggcagggag ggggctggga aagaacttgg 4912 acttctaaag gcggagggtc tccctgggca ccctgcaggc aggcagacca cggtgtgggg 4972 ggtgccccac aaggcccagc cctgggcaag gaagctttgg aagcagcaag gtgggggtca 5032 ggctacaggt gccccacctc cccagagccc tgcagtcacg tgaggcccct gtgcagtaga 5092 gagcctttct ccagcccatg ctggcagggg ccggggctgc cgcatctgcc tggagcctgg 5152 gcagcacctc cgggactgac cttcggcagt ggctggggga ctgctttcag tgcctgctgt 5212 tcgtgactca gaaacagaag aaaaacactg agaaaaagca t taaaaataa gccaaaataa 5272 gactattggt aaacacctaa atttttgtaa gaaaatttaa aaattaaagc agcaaaggaa 5332 ctttttgctt tctgcc 5348 <210> 170 <211> 5881 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1159) <400> 170 c atg atc agc ttt gtg gat cct ctt gtg acc aat tac aca gtg gtg gac 49 Met Ile Ser Phe Val Asp Pro Leu Val Thr Asn Tyr Thr Val Val Asp 1 5 10 15 ttc aga aat aga gca act gct ctg att gaa gat ata ttt gcc cga gac 97 Phe Arg Asn Arg Ala Thr Ala Leu Ile Glu Asp Ile Phe Ala Arg Asp 20 25 30 aaa att cct att gtt gtg gga gga acc aat tat tac att gaa tct ctg 145 Lys Ile Pro Ile Val Val Gly Gly Thr Asn Tyr Tyr Ile Glu Ser Leu 35 40 45 ctc tgg aaa gtt ctt gtc aat acc aag ccc cag gag atg ggc act gag 193 Leu Trp Lys Val Leu Val Asn Thr Lys Pro Gln Glu Met Gly Thr Glu 50 55 60 aaa gtg att gac cga aaa gtg gag ctt gaa aag gag gat ggt ctt gta 241 Lys Val Ile Asp Arg Lys Val Glu Leu Glu Lys Glu Asp Gly Leu Val 65 70 75 80 ctt cac aaa cgc cta agc cag gtg gac cca gaa at gcc aag ctg 289 Leu His Lys Arg Leu Ser Gln Val Asp Pro Glu Met Ala Ala Lys Leu 85 90 95 cat cca cat gac aaa cgc aaa gtg gcc agg agc ttg caa gtt ttt gaa 337 His Pro His Asp Lys Arg Lys Val Ala Arg Ser Leu Gln Val Phe Glu 100 105 110 gaa aca gga atc tct cat agt gaa ttt ctc cat cgt caa cat acg gaa 385 Glu Thr Gly Ile Ser His Ser Glu Phe Leu His Arg Gln His Thr Glu 115 120 125 gaa ggt ggt ggt ccc ctt gga ggt cct ctg aag ttc tct aac cct tgc 433 Glu Gly Gly Gly Pro Leu Gly Gly Pro Leu Lys Phe Ser Asn Pro Cys 130 135 140 atc ctt tgg ctt cat gct gac cag gca gtt cta gat gag cgc ttg gat 481 Ile Leu Trp Leu His Ala Asp Gln Ala Val Leu Asp Glu Arg Leu Asp 145 150 155 160 aag agg gtg gat gac atg ctt gct gct ggg ctc ttg gag gaa cta aga 529 Lys Arg Val Asp Asp Met Leu Ala Ala Gly Leu Leu Glu Glu Leu Arg 165 170 175 gat tttc cgc tat aat cag aag aat gtt tcg gaa aat agc cag 577 Asp Phe His Arg Arg Tyr Asn Gln Lys Asn Val Ser Glu Asn Ser Gln 180 185 190 gac tat caa cat ggt atc ttc caa tca att ggc ttc aag gaa tttc Tyr Gln His Gly Ile Phe Gln Ser Ile Gly Phe Lys Glu Phe His 195 200 205 gag tac ctg atc act gag gga aaa tgc aca ctg gag act agt aac cag 673 Glu Tyr Leu Ile Thr Glu Gly Lys Cys Thr Leu Glu Thr Ser Asn Gln 210 215 220 ctt cta aag aaa ggt att gag gct ctg aaa caa gta act aag aga tat 721 Leu Leu Lys Lys Gly Ile Glu Ala Leu Lys Gln Val Thr Lys Arg Tyr 225 230 235 240 gcc cgg aaa caa aac cga tgg gtt aaa aac cgt ttt ttg agc aga cct 769 Ala Arg Lys Gln Asn Arg Trp Val Lys Asn Arg Phe Leu Ser Arg Pro 245 250 255 ggt ccc att gtc ccc cct gtc tat ggc tta gag gta tct gat gtc tcg 817 Gly Pro Ile Pro Val Tyr Gly Leu Glu Val Ser Asp Val Ser 260 265 270 aag tgg gaa gag tct gtt ctt gaa cct gct ctt gaa atc gtg caa agt 865 Lys Trp Glu Glu Ser Val Leu Glu Pro Ala Leu Glu Ile Val Gln Ser 275 280 285 ttc atc cag ggc cac aag cct aca gcc act cca ata aag atg cca tac 913 Phe Ile Gln Gly His Lys Pro Thr Ala Thr Pro Ile Lys Met Pro Tyr 290 295 300 aat gaa gct gag aac aag aga agt tat cac ctg tgt gac ctc tgt gat 961 Asn Glu Ala Glu Asn Lys Arg Ser Tyr His Leu Cys Asp Leu Cys Asp 305 310 315 320 cga atc atc att ggg gat cgc gaa tgg gca gcg cac ata aaa tcc aaa 1009 Arg Ile Ile Ile Gle Asp Arg Glu Trp Ala Ala His Ile Lys Ser Lys 325 330 335 tcc cac ttg aac caa ctg aag aaa aga aga aga ttg gac tca gat gct 1057 Ser His Leu Asn Gln Leu Lys Lys Arg Arg Arg Leu Asp Ser Asp Ala 340 345 350 350 gtc aac acc ata gaa agt cag agt gtt tcc cca gac cat aac aaa gaa 1105 Val Asn Thr Ile Glu Ser Gln Ser Val Ser Pro Asp His Asn Lys Glu 355 360 365 cct aaa gag aag gga tcc cca ggg cag aat gat caa gag ctg aaa tgc 1153 Pro Lys Glu Lys Gly Ser Pro Gly Gln Asn Asp Gln Glu Leu Lys Cys 370 375 380 agc gtt taagagacat gtccagtggc ctttggaaag gtggtgggga tccagttcag 1209 Ser Val 385 gagggagggg tatgtttgtc tcccagtctg ggcaaaggag tgctatgcgg aattctctgc 1269 atagcagaaa agctcccacc attttctttt gatgtggttt taaagtctca cgttctctat 1329 aatagaaaca gcaggtcttg tcagctcctt gtgtggctga tgtgtctgga aatgatgtag 1389 ttcaggaaag catttttttt ttctttgaac cttaaaggtt ctattattaa aagcagcaca 1449 gattccacat ttttatacat gaggatcttc tttgtggtga ataccaggat tgactgcatc 1509 cctttaaaga agttttatgt ccctgactct ggctaaaatt atctaggtagtt 15 gtgagccaca tattgggagt tctagatttg agtgaatggc 1629 aggaaagggc catctccatt gagatgatta agtgaaccaa actagttctc agaattctac 1689 agagaaggag ggaatcagac tgaggaagct gtgacatagg acttgaagac caaagacttt 1749 gaaatttgcg agctgctcat gtgtgagtta ttatcactgc tgtctttcta ttgagttaca 1809 aatctatatt tttattgaag tttaaataaa gaaaaaattt acaagagcct ctttgatcct 1869 taaaaagata tacaagtcca tgcctagttt atacacagta tgctctgtta tcaatgtgat 1929 agctttttct caaatttgac actttttgta gatcatgctg tctgttcatt tatgtagcgg 1989 gtgtttattt aacacgttat agtccttgaa gacatctaga gagggtcttt tattggagat 2049 ctattacttc caattgaagc cctctttctg gagtgacctg agctgccagc aatgttaaac 2109 agatacttat ttatatataa catcaaatat agcattttta gggtataatt cagcagcatt 2169 aactacattc acaatgttgt gcaatcgttg ccactatttc caaaacgttt ttgtcactcc 2229 aaacaaactt tgtgcccttt aagcgttaac tccccattca aatacatttt gtttgtgcag 2289 aatctactct atgagaggcc ctgaattagg ctaaagggaa tgcagagatg agatgtggtt 2349 cttgccttca gggagcttat aaataattgc atgtgtacac aaacaccaat ccaggcaaga 2409 cagtatcaaa ggccgtaaga gctgtg taga atttcagttt agaaggaagg gaagggatca 2469 tggaaggagg agcatttctg ctgcaccttg aaaagcaatt cttgataaat gttttgtttc 2529 ctatgcatat aagacttcat agaggagaag gtagagtaaa aaaactatct aacttgattg 2589 acctttttaa acagtgctga attccagagc ctcacccact tttaactgat ttgaatctca 2649 aaaataaatt tattctctgg gcaaagaagt ttattaacta ctttaggacc taacaaggtg 2709 ggaagccaca tcttcccggt gggagtggag atgagtactt actgtgagcc aagcagtgcc 2769 aagtcgtttt tatatgttat cttctcacac agccctggga gggagatgct gtttcctttg 2829 ctgttaacca gggaggaaac taaggctcag caatggagta cagctagcaa gcggtagagc 2889 tggaattgag gtgaggctgg tagactcaag ctattaagca ctgtgttaag ctggcagttt 2949 gtagggaaga acctttagtt tctctgaaat attcttcgtt caagttgcta agtatgtttt 3009 aaagcctaaa aaggtttcag tagacaagca ggaaaaacta gttttaataa ttgtacgtca 3069 aaaagctttt aatccttcca tctgaaatac ctggagcagt aacttctcat tgaactcatt 3129 gttatctcta tggcaattgg aaatcaggcc ttttttacca aaaaaaaagt gtctaatatt 3189 tatgaagcac ttactaagtg taaggcagtg tggttgagcc cactgttcat attcttagaa 3249 attgtaaatt cagccaaatg aaattccttt atcagcagca aagagcctgg gaaaggcaga 3309 acactcacta gaaatctgcc tggtgctctg gtctgaagca ttgccctgag tagatttccc 3369 cttttgtgcc tgctccccta tgaatgactt cgctgttgag tgtagggaag gaaagtaatt 3429 tgtcttgtgg tggtcgtaaa tgtagagatg aaagaattct ttatctcttg tatggatggg 3489 gaaactgagg cctaaaacat ggatgttcca gtcacagagc aaggcaaagc tgggacaaac 3549 cttagatcac ctttcttact ctattactaa atctcatacc aaatctcatt tgagagctga 3609 aaagtaccat agagctttgg gctatttgct cagcctggag tgagaatgag gaatgccatt 3669 ttgtaccatc tggccatagc aatcccaagg caagcagagc cctccagtcc aggtatccag 3729 agcctccagt ccatcacacc agcagtgcta tctaaatggc tttggcaatt aattccaata 3789 ctcagtgagc tattaggttc atctgcttct gtcagtaaaa atcttgatta ggctttagat 3849 acttctcaca gttcaggcag tgctgttgta agtgggtaga aagtactttg attctgaaga 3909 gagatctaga cttgaaaata ctttgcttga ttcttagggc taagcaagag aacagctcat 3969 ctgtattcca ggaatatggc ttgatccttc ctaactctca gtaatttttt gtcctctctt 4029 agctctcttt agttccaaag aggatttttt tgcttaaaac aaaacaaaac acccagtata 4089 acattaaaaa ataacagtcc gggagtggtg gctcac gcct gtaatcccaa cgctttgggt 4149 aactgaggca gaaggatcac tcaagcctag gagtttgaga ccagcctagg caacatggtg 4209 agacccagtc agcacaaata tatacataca tacatactta catatatata tatgtatgca 4269 tgccgggtat ggtgggtcat gcctatagtc ccagctacgt ggaaggctca ggtaggagga 4329 tggcttgggc ctgggagatt gaggcttcag tgaaacatga tcatgccact gcattccagc 4389 ctgggtggca gagcaagacc atgttgctca aaaagaaaat aaaactaaca accccctccc 4449 ccaaacacac atgcatgaaa tcaacctttt atgaatgcag tgacttgtca atatccctag 4509 cacctagaca cagtcaaata tttgttgaat caattgcatg aaagcataaa aactaagtag 4569 gtctctacat aagtgatctg cttcaattgt taaatacttt ttaaccagga tgaagaaatt 4629 ttgggatagc caccagcagg aatttctgta tttgattatc acctacttgg gcagttaagg 4689 ctgttttcta aaatgatggc taactggtta tttgtaaagc tactctgaat gcttacaaag 4749 gaagctgcat gtttgtatta gttcaggtaa aaggctaagt tgctataaca aagagactca 4809 acaatacagt ggcttaaaga acaaagaagt ttattctttc tcacgtaaca gctctgaagg 4869 gaattaacct gtctgaagtg agtgatccag gtcattgggg cagctgtgca ccaaatggtc 4929 attcagggac acagattcct cgtatcatgt tgcttctcca tcctctggag cattgtcctc 4989 atctgctgca tgcttgaagc tgggtcatca ctggtcctag ctgatgggaa ggggaaaagg 5049 aacagggagg aggtagaccc gctgcctgaa ggcctggacc ctgcagtggc acggatactt 5109 ctgcctacat tctcactttc cattggcaat gacttagccc gatggccaca cctacctgcc 5169 aggaaggctg agaaacgtag tcaagccatg tgccaagaag gaatgggagg acaggttttg 5229 gtgggcaact tacagtcacc actagattgg tatcatggaa ggagcactca attccaggct 5289 catttaacta attaatttaa ctcagtttgc taggggcaaa tctatttctc catctgtgaa 5349 attagtgagt tgtattgagc tgacctctga aatatttcaa aaagtaaagc ttgagaaaat 5409 cctggctggt aggactttaa gatgagaata agaaagcatt atagggaatg ggagactgta 5469 taaacatcag ggccagtggc tcatactgta aagatggtgg ggaggaaaga tggaaggtgt 5529 tttggtggca ttgttgaata actgaactaa tgacttaact gcctactttc agactttatg 5589 tggcagggag gggacagggg gagaaagaaa ccactatttg tatttgcagc tgaacacttt 5649 actttctaat atactatctg tgtgatcttg ggaatattgc ttaaaagcct gtttcctcat 5709 gtataaaatg aagttatctg tattccacgg gacatggtaa ggattaagtg aggtcctgtt 5769 gtaaatagca tagtgttttg gcactgtagt gcccagtaaa tggtaa gtac aaattggatt 5829 tatttgcttc attggggaaa aattgttaat gctattaaaa tgttggttta tg 5881 <210> 171 <211> 5168 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1060) .. (2244) <400> 171 cttgtgagat tcatttctag agttgatgct atttcttttt gtcaggggac ctttactcct 60 ggcctgggat tcagtggaag aaattgttca tgatacaatt actaggaacc tacaagcttt 120 ttataacatg ctacgctcat atgaccttgg agacacaggg cgcattggcc gaaataattt 180 caagaaaatc atgcacgtct tctgtccatt tttaacaaat gcacatttca taaaactctg 240 cagtaagatt caggacattg gttcaggaag aatcctttac aagaaacttt tggcatgcat 300 aggaattgat ggcccaccca ctgtctctcc agttcttgtt ccaaaggatc agctgttaag 360 tgaacattta caaaaagatg aacagcagca gccagatctt tctgagagaa ccaagctcac 420 ggaggataaa accaccctga ccaagaagat gaccacagaa gaagtgattg aaaaattcaa 480 aaagtgtata cagcagcagg acccggcatt caaaaaacga tttcttgact tcagcaagga 540 gcctaatgga aaaattaacg tgcatgactt taagaaggta ctggaagaca ctgggatgcc 600 catggacgat gatcagtatg ccctgctgac cactaaaata ggcttcgaga aggaagggat 660 gagctatctt gattttgcag caggatttga agatcctcca atgagagggc cggaaaccac 720 tccgccgcag cctccaactc cttcaaaaag ttacgtgaac agccacttta tcaccgcaga 780 agaatgcctg aagcttttcc ctaggaggct gaaggagtca ttccgggacc cctactctgc 840 cttctttaaa acagatgctg acagggatgg cataatcaac atgcatgacc ttcacagact 900 gctcctgcat ctactgctta atctcaaaga cgacgagttt gagcgcttcc ttggccttct 960 tggcttgaga cttagtgtca ctttaaattt tcgggaattt caaaatttgt gtgagaagag 1020 accatggaga acagatgaag cgcctcaaag actcattag aat ttt cta gaa acc 1074 Asn Phe Leu Glu Thr 1 5 gat aat gag ggc aat ggc att ctt cga cgc cgg gac ata aag aac gca 1122 Asp Asn Glu Gly Asn Gly Ile Leu Arg Arg Arg Asp Ile Lys Asn Ala 10 15 20 ctg tac ggt ttt gat att ccc ctc aca cca aga gag ttt gaa aag ctt 1170 Leu Tyr Gly Phe Asp Ile Pro Leu Thr Pro Arg Glu Phe Glu Lys Leu 25 30 35 tgg gca aga tac gac acc gag gga aaa ggg cac att act tac cag gaa 1218 Trp Ala Arg Tyr Asp Thr Glu Gly Lys Gly His Ile Thr Tyr Gln Glu 40 45 50 ttt tta cag aaa ttg ggt att aac tat tcg cct gct gtc cat cgg ccc 1266 Phe Leu Gln Lys Leu Gly Ile Asn Tyr Ser Pro Ala Val His Arg Pro 55 60 65 tgt gca gag gat tat ttc aac ttc atg ggt cat ttt aca aag cca cag 1314 Cys Ala Glu Asp Tyr Phe Asn Phe Met Gly His Phe Thr Lys Pro Gln 70 75 8 0 85 cag cta cag gaa gag atg aag gag ctg cag cag agc aca gag aag gct 1362 Gln Leu Gln Glu Glu Met Lys Glu Leu Gln Gln Ser Thr Glu Lys Ala 90 95 100 gtg gca gcc agg gat aag ctt atg gac cgc cat caa gat atc agc aaa 1410 Val Ala Ala Arg Asp Lys Leu Met Asp Arg His Gln Asp Ile Ser Lys 105 110 115 gca ttc acc aaa act gat caa tcc aaa acc aac tac ata tcc ata tgc 1458 Ala Phe Thr Lys Thr Asp Gln Ser Lys Thr Asn Tyr Ile Ser Ile Cys 120 125 130 aag atg cag gaa gtg ctg gaa gaa tgt gga tgt tct ctt acc gaa ggg 1506 Lys Met Gln Glu Val Leu Glu Glu Cys Gly Cys Ser Leu Thr Glu Gly 135 140 145 gag ctg acc cat ctg cta aac agt tgg gga gtc agc cgg cat gat aat 1554 Glu Leu Thr His Leu Leu Asn Ser Trp Gly Val Ser Arg His Asp Asn 150 155 160 165 gct atc aat tac ctc gac ttc ctg aga gca gtg gag aac agc aag tca Ala Ile Asn Tyr Leu Asp Phe Leu Arg Ala Val Glu Asn Ser Lys Ser 170 175 180 aca gga gct cag ccc aag gaa aaa gaa gag agc atg cca atc aat ttt 1650 Thr Gly Ala Gln Pro Lys Glu Lys Glu Glu Ser Met Pro Il e Asn Phe 185 190 195 gca acg ctg aat cca cag gag gct gtg agg aag atc cag gaa gta gtt 1698 Ala Thr Leu Asn Pro Gln Glu Ala Val Arg Lys Ile Gln Glu Val Val 200 205 210 gag tcc tcc cag ctg gct ttg tcc acg gca ttt tct gca ttg gat aaa 1746 Glu Ser Ser Gln Leu Ala Leu Ser Thr Ala Phe Ser Ala Leu Asp Lys 215 220 225 gag gat aca gga ttt gta aag gct aca gaa ttc gga caa gtt ctt aag 1794 Glu Asp Thr Gly Phe Val Lys Ala Thr Glu Phe Gly Gln Val Leu Lys 230 235 240 245 gat ttc tgt tac aaa cta acg gac aat cag tat cat tat ttt ttg agg 1842 Asp Phe Cys Tyr Lys Leu Thr Asp Asn Gln Tyr His Tyr Phe Leu Arg 250 255 260 aaa cta aga att cat cta acc ccc tat ata aat tgg aaa tat ttt ctc 1890 Lys Leu Arg Ile His Leu Thr Pro Tyr Ile Asn Trp Lys Tyr Phe Leu 265 270 275 cag aac ttt agc tgt ttc ctt gag gag aca gct gat gag tgg gct gag 1938 Gln Asn Phe Ser Cys Phe Leu Glu Glu Thr Ala Asp Glu Trp Ala Glu 280 285 290 aaa atg ccc aaa ggc ccg ccg cct acc tct ccc aag gcc aca gcc gac 1986 Lys Met Pro Lys Gly Pro Pro Pro Th r Ser Pro Lys Ala Thr Ala Asp 295 300 305 aga gac atc ctg gct cgc ctc cac aaa gca gtg act tcc cat tac cat 2034 Arg Asp Ile Leu Ala Arg Leu His Lys Ala Val Thr Ser His Tyr His 310 315 320 325 gcc atc acc cag gag ttt gag aat ttt gac acc atg aaa acg aac acc 2082 Ala Ile Thr Gln Glu Phe Glu Asn Phe Asp Thr Met Lys Thr Asn Thr 330 335 340 atc tcc aga gag gag ttt agg gcc att tgt aat cgc cgc gtc caa atc 2130 Ile Ser Arg Glu Glu Phe Arg Ala Ile Cys Asn Arg Arg Val Gln Ile 345 350 355 ctg acg gac gaa cag gta aga aac gcc agt cag tcc tca ccc tgc aca 2178 Leu Thr Asp Glu Gln Val Arg Asn Ala Ser Gln Ser Ser Pro Cys Thr 360 365 370 ccg ttg gct gag cgt cag cct ggt ccc tgg cca gaa tgt aca gag ttt 2226 Pro Leu Ala Glu Arg Gln Pro Gly Pro Trp Pro Glu Cys Thr Glu Phe 375 380 385 385 aag act gtt ctc tat ttt taaaatgtttca tgt tattttgttt 2274 Lys Thr Val Leu Tyr Phe 390 395 ttcaatcttc ctgaagattc acaggaatct tctgtttatg taacaactat aaattacacc 2334 attttcatca gggtacaaat actgtcactg ttgcctttaa aatcaaattc aactccgc tt 2394 cggctcccac actccttctc ccttccctgg agcatcccgg aggtaatgtg gtctgggtct 2454 gtcatgggca gcaactatct ggggccagtg ttgcgcaggc agtaaaaaga atgtaccaag 2514 acagttgtag gtaaaaaagg cagatgtatt agaaaaagta tgaaaatatg ttgcaagagt 2574 gcaaggggca agtcagcaag agaaaagctg actgcaaaga gacaaaggtt tgctggagat 2634 tttataggat ggtgcttgtg ctgggtgctg aagaaggctt tgtgcagtac tggaaacacc 2694 aaggttgcag tgagctacct tgcatttttc tatgagccgg gggtctggtg atagctgggc 2754 gcaggaaggt tgttatttgt gcaggaggac tacgtgttct ggaccatgaa caaaggcaga 2814 cttagcggct tacctgcttt ttcattttgc tttcctctgt tcccaccagc ctgattcctt 2874 tcccctaatt aggactccac atggtccaaa gaaggtgggc agtcggtccc cacgcctgga 2934 gggtcacaga ccctggcagg aggctggcgc tcctcccgcc accccaacct gccttctcct 2994 tgctactacc tggtgctgct gctggcagtg tgggatgctc cgggctgctg ctctaagcat 3054 gctgggtaca tgccacccct ggtgggcctc tccactgtgc acaggctgga cacaggccct 3114 gcctctctaa gatcctcctc cctatcacag aatccccaga aggaggttct tcccagcctc 3174 ctcccctaag gactggactg agctcttctg tggctcaaag gctccgacaa cctgctcccc 323 4 tgggccgcta tggcccttca tggccttcca aggccaagag cacctcccag tggggtggcg 3294 tcctcagagt ctgccttgcc atggcagctg tgggagggaa gagagcacct gcccagcctg 3354 cctcccatcc atagtcacac tgaacaccag caccagggga gcagtgcccc aggttgcttt 3414 gttcctcgct gtgccctaaa tgccaaagca gtgcagggcg ctgagtgggt gctcagtaca 3474 tgctgctgaa tggacagcgt ccatactccc cagcccttca ccgtcctcgg cagccccgtg 3534 gctgatcagc caagtaacac agagcaccac tgatccagtt acagaagtag atttcccttc 3594 actcagaaaa tgcacagcta caagccctct ctagttctca aatgcatcaa tgtcccattc 3654 ccagagaata attcagacta aaacataaaa tccccaaata cttaacaaag caactctgcc 3714 tccctccttc ctcctggttc tgctcagtct cagcccaggg agttccctgc agacactgcg 3774 tggaaatgtc actctttcgc ctccaaaact gggccattac aacctcttgt ctcattttgt 3834 cagagttgca gggtaaggcc ttggaagtat tcatagggaa gcgtgatcat cgcagtcacc 3894 cctggctcta ctcacagctc tgaactcact gccccaagaa tgcatgccgt aaagacatta 3954 agaatgtgac tatcaggttt aacattccta aaatatcacc tttctcaagc attttggtgt 4014 gatcattttt gctaagcaaa attaaatgct gtttccaaat gatcctgccc cattgcacgt 4074 caa agccgag caaactctgt atttgcaaat actcctctta gcataaatga aaataagcct 4134 ttgaaattaa tacagttgca tttattattc tatggggcca agtaatcaag gttttactaa 4194 taaagatttt tttaatttca cctaaatgag taaaatttta ctctaattat agatagaaat 4254 taatgacatg ctgacatatc tggcattcat cacagagaat tcaattttaa ttgtccacta 4314 agaaaacttc accatcctca gcacatcaag ccccttcccc aaccaaatta aacacttatt 4374 tttaaacgcg gctttctaaa aataagctga cgtgtctctt acatgcagcc aacaaacata 4434 tgaaaaaaag ctcaacatca ctgagcatta gagaaatgca aattaaaacc acagtgagat 4494 accatctcac gccagtcaga atggctacta tttaaaagtc aaaaaacaac agatgctggt 4554 gaggttacag agaaaaagga atgcttctac actgttggta gaagttggga gtgtcagtta 4614 gtttagccat tgtggatgac actgtggtga tttctcaaag acctagaggc agtaatacca 4674 tatgaccaag ccatcccatt actgggtata tgccccaagg aatataaatc attctattat 4734 aaagatacac acacgtatgt acattgcagc gcttttcaca atagcaaaga caaggaaaaa 4794 aactaaatgc ccatcagtga tgggctggtt aaagaaaatg tggtacatct acaccgtgga 4854 atactatgca gccataaaaa ggaatgagag gccgggcaca gcggttcacg cctgtggtcc 4914 cagcatttt g ggaggctgag gtgggtggat cgcgaggtca gggtttcaag accagcctgg 4974 ccaatatggt ggaaccccgt ctctactact aaaaatgcaa aaaaattggc tgggcacggt 5034 ggcacgcatc tgtagtcccg gctgctcggg aggctgaagc aggagaatca cgtaaaccca 5094 ggaggcggag gttgcagtga gccgagatca caccactgca ttccagcctg ggcaaaagag 5154 cgagactctg tctc 5168 <210> 172 <211> 5246 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (476) .. (1306) <400> 172 tgggatgtgt aagaggagaa ggagcagccc agatgatctg gcccagatgc gctggcagac 60 tccgcatgtt ctgctttcag ggacagtggc ctggctggtg cacacagtcc tgtggggctc 120 atgaggtcat gggaagcagc cgagcaggag gctcagggcc ccatgactgc tacagaagtt 180 ctccgctggg cactggggtc agctggactg gcttccagct ggccgtggac agcctcagtt 240 tcctcatcta ggtaacagag acactgcctc accagagtgg gctgcaaagg gaggcagtgt 300 caagtcttgg caccactcca gccccgccgt gggttcctgt agtgttctat tatttgtttg 360 ctcagggctg agctgagact ctggacctgg gaaaaaggaa agccagagta ggcccagggt 420 ccccaacccc agagtgcttc agccttgggg gcagctccct aaggccccag gttga ccc 478 Pro 1 tgg agc tac tct gca ccc tct gcc ccc agg tct ctt gtg ggg tca gcg 526 Trp Ser Tyr Ser Ala Pro Pro cca aga gta gaa aca ctt ccc cca gta gtg ggg agt act agg agc 574 Leu Pro Arg Val Glu Thr Leu Pro Pro Val Val Gly Ser Thr Arg Ser 20 25 30 tcc gtg ggg att aag gct tgg gca aat gcc tac aga act gac cta ccc 622 Ser Val Gly Ile Lys Ala Trp Ala Asn Ala Tyr Arg Thr Asp Leu Pro 35 40 45 atg gaa ata tgt ggt tat ata aaa cta tgt tta ctt tcg ttt ttt tgt 670 Met Glu Ile Cys Gly Tyr Ile Lys Leu Cys Leu Leu Ser Phe Phe Cys 50 55 60 65 ttg tgt ttt cat ata gat aac aag aaa tct caa gct tccgt agt gat 718 Leu Cys Phe His Ile Asp Asn Lys Lys Ser Gln Ala Ser Val Ser Asp 70 75 80 cct atg aat gca ctc cag agc ctg act ggc gga cct gct gcg gga gcc 766 Pro Met Asn Ala Leu Gln Ser Leu Thr Gly Gly Pro Ala Ala Gly Ala 85 90 95 gct gga att ggc atg cct cct cgg ggc ccg gga cag tct ctg ggc ggg 814 Ala Gly Ile Gly Met Pro Pro Arg Gly Pro Gly Gln Ser Leu Gly Gly 100 105 110 atg ggt agc ctt ggt gcc atg gga cag cca atg tct ctc tca ggg cag 862 Met Gly Ser Leu Gly Ala Met Gly Gln Pro Met Ser Leu Ser Gly Gln 115 120 125 ccg cct cct ggg acc tcg ggg atg gcc cct cac agc atg gct gtc gtg 910 Pro Pro Pro Gly Thr Ser Gly Met Ala Pro His Ser Met Ala Val Val 130 135 140 145 tct acg gca act cca cag acc cag ctg cag ctc cag cag gtg gcg ctg 958 Ser Thr Ala Thr Pro Gln Thr Gln Leu Gln Leu Gln Gln Val Ala Leu 150 155 16 0 cag cag cag cag caa cag cag cag ttc cag cag cag cag cag gcg gcg 1006 Gln Gln Gln Gln Gln Gln Gln Gln Phe Gln Gln Gln Gln Gln Gln Ala Ala 165 170 175 cta cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag cag gct cag 1054 Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Phe Gln Ala Gln 180 185 190 cag agt gcc atg cag cag cag cag ttc caa gca gta gtg cag cag cag cag 1102 Gln Ser Ala Met Gln Gln Gln Phe Gln Val Val Gln Gln Gln Gln 195 200 205 cag ctc cag cag cag cag cag cag cag cag cat cta att aaa ttg cat 1150 Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Ile Lys Leu His 210 215 220 225 cat caa aat cag caa cag gtc cga gct ccg atg gtg gtg cag cag ccc 1198 His Gln Asn Gln Gln Gln Val Arg Ala Pro Met Val Val Gln Gln Pro 230 235 240 cca gtg cag ccc cag gtg cag cag cag cag aca gca gta cag aca gct 1246 Pro Val Gln Pro Gln Val Gln Gln Gln Gln Thr Ala Val Gln Thr Ala 245 250 255 cag gct gcc cag atg gtg gct ccc gga gtc cag gtg agg gcc tgg ggg 1294 Gln Ala Ala Gln Met Val Ala Pro Gly Val Gln Val Arg Al a Trp Gly 260 265 270 tgg agg gct cca tagtcatcag caggtgcatg ttcacctgcg catgtagtgc 1346 Trp Arg Ala Pro 275 tacagtgagg gttctggttg gattaggggc tgggggctaa gttggtaaag caggggcttc 1406 tctccccctt gcactctgca agacacccct ggagtccttg gggtgggcag ctgtgcttgg 1466 tcatgtctag gacccaccag ccgcatagtg cgtgtcgttt ccagctttgc tcgggcatcc 1526 ttcattatcc ctcttccttg ccactctgag tgactctggg aacatgtatc agagagtaga 1586 aggctgcagt tttctcctca cctctcatct tccatttgag agtctgagta cagagctgac 1646 cagggtggag ggcagctttc tagacactcg gaagcagatg ggagccacat gcagcaggag 1706 cgtgggagaa ggcatcctgg tgctcgcctg cactcaggga ctccggcgct gtgtggtcag 1766 ccagagcagc ctccccatgc tgtcctcgcc gtcaccgggc cagcaggtgc agaccccgca 1826 gtcgatgccc cctccccccc agccgtcccc gcagcccggc cagcccagct cacagcccaa 1886 ctccaacgtc agctctggcc ctgccccatc tcccagtagc ttcctgccca gcccctcacc 1946 gcagccctcc cagagcccag tgacggcgcg gaccccacag aacttcagtg tcccctcacc 2006 tggaccttta aacacacctg tgaaccccag ctctgtcatg agcccagctg gctccagcca 2066 ggctgaggag cagcagtacc tggacaagct gaagcag ctg tcgaagtaca tcgagcccct 2126 gcgccgcatg atcaacaaga tcgacaagaa cgaagacaga aaaaaggacc tgagtaagat 2186 gaagagcctt ctggacattc tgacagaccc ctcgaagcgg tgagctttgc ccacagccca 2246 cggagggtcc acaagggcac agatagccca gccatggatg ggcacttggt gatgatgtgg 2306 gtttaacaaa ggcaccaggc agctctttgg accctggcca gaggcctcca aggctccact 2366 ctggtgtgtg ctggggcttc aagcccaggc ttcatcttgg cccatgccca gcctttgccc 2426 tattcctggc tgctgctgtg gccctcatgc tgggccatca cagccagacc tcatccagtc 2486 agcagccagg ggcccagctt gcagtggcct gaccatcagc tggcccagat gggcctgagc 2546 ctgacctgga gttctgcccc tgacttgctg gtgaccatgg gcaggcgact gcatctcagt 2606 taccccattt gtagcccacg tgtgttgtca tgaaaatgaa acaaggtggc gctggtgaga 2666 agcaggtgga aggcagggct gctggccaca ggctgctgtg aggatcagag ctcgggcagt 2726 acctccaaac tgcatgggca ttggcatata cctccctttc acctcaactc aggctatccc 2786 ccaacccctg tctagaaggg tctctctgtt ctgcttgtct ggatagaatg ccagtcacta 2846 ttgggtggtc ctccaggtct tcatgggttg atcctttgtt agggttatag ggatgagtgg 2906 ggcagggact ggcctacatg acaatgaggc attcacagcc tg atcagggg cctggccact 2966 gtcccttctc ttgacccatc acctcactct gccaaccagg gacaagcagc tcctggggtt 3026 gagggctgcc tgccttcaac tctgggtctg ggaacagctg gtcaactggt aggagctcct 3086 gcagaggttt ctgatggctg aggcccagtg gcagtagttg ggatcctgag cctgagaact 3146 gccatgtctt ccactctttc agcccaagtc ctctctctct gcaggtgtcc cctgaagacc 3206 ttgcaaaagt gtgagatcgc cctggagaaa ctcaagaatg acatggcggt ggtgagtggg 3266 atgccagaca cccctagggg aaccagggct ctcctaagag ctcctgggag tgctgctgag 3326 agggccttca aggtcagggc atctgggcgg gggccgggcc tgaccttgga ccctgcccac 3386 gaggcttcct ggccaggtct gctgtgctgg gtgggaacat gggagaagtc accctctgtc 3446 tacggccccc gtgggtgcct ccttcaccca tttcagagga ggcagggact gtagggagga 3506 taggctgtgg gggtggggga ttattcccag gatcagccaa cattgtctgc acaagggtgg 3566 aggctgtgag agaggcctcg ggaatctgac tgtgagtgac catgggcctg gggtgtgaag 3626 gccccctaaa tggggaaccc tcgggtcccg ggctgctgac cgtgcccatc ctgtctccag 3686 cccactcccc caccgccccc ggtgccaccg accaaacagc agtacctatg ccagccgctc 3746 ctggatgccg tcctggccaa catccgctca cctgtcttca accattc cct gtaccgcaca 3806 ttcgttccag ccatgaccgc cattcacggc ccacccatca cgtatgtcca gctgggctgg 3866 gctttgcgga gggcggccag ccctgggccg cgtgtgccag gtgtggtcac catgccgcct 3926 ccccggggcc ccagtggtgt gcacccggaa gcgcaggctt gaggatgatg agcggcagag 3986 catccccagt gtgctccagg gtgaggtggc caggctggac cccaagttcc tggtaaacct 4046 ggacccttct cactgcagca acaatggcac tgtccacctg atctgcaagc tggatgacaa 4106 ggacctccca agtgtgccac cactggagct cagtgtgccc gctgactatc ctgcccaaag 4166 cccgctgtgg atagaccggc agtggcagta cgacgccaac cccttcctcc agtcggtgca 4226 ccgctgcatg acctccaggc tgctgcagct cccggacaag cactcggtca ccgccttgct 4286 caacacctgg gcccagagcg tccaccaggc ctgcctctca gccgcctagc caagactgca 4346 gggatggccc gcagcctcat cggggccaag gacacacgcc tcctgtcaga cacttctagg 4406 tgttggcttc cttagagagc ctggggttag gttagctttc ctgcttttat cttctgcctt 4466 ggggacctgc caaacgaaat cccacacctg tacagaactg ggataggcgc agtggagcgg 4526 gttgcttggg gggcgttggc cgacttctta gagaaggccc tccatgtgac ttcctcccag 4586 gagccagatg cgatcctcag gctgctctca ccgtggcctg tccacggtcc a ggtccatct 4646 cagcagcgtg agggtgcact cagggtgttg ttagagcgtc tcgtgtgtgc tagacgcacc 4706 cctactcgtt cctatagaac acagaggaca taggaaaccc ttaaaacaca catgggattc 4766 tctggtcaca gttttgggtt caggctatgc tgctttgggc aggtggagca ccccccgagg 4826 aagcctgcaa gtccagggca caggctgcct tttggaggga gggctggccc ataggtgctg 4886 ctggctcccc gccaccagct gggcctcagc cctcacggca ttcctgctga gcaccgtggg 4946 gcacccaggg agcaggggcg tcagggatcc tgctgccggc acccctgtgc cgctggcatg 5006 agggccgtgt ccccactgtg aaggatgaag agcaaggccc tcaggacccg tgtcctcaga 5066 gcaccacaca ctgagcaccc agagacagcg ggcctggcag cgggccgggc catgcaggga 5126 gcgcctccct atgttgcctg ccactctggg caccggccag caccctctgg tgagaagagg 5186 tccccccttt ttatgtgcac taccccacctacctacctacctacctacctacctacctacctact <210> 173 <211> 5264 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2958) .. (4760) <400> 173 cagtccctaa agaacatcct gattccccca gtcttcaagc acatgaattc agaatgaaag 60 gtttgccatg gctaaggaat gtgactcttt gaaaaccatg ttagcatctg aggaactttt 120 ttaaactttg ttttagggac ttttttttcc ttaggtaagt aatgatttat aaactccttt 180 ttttttttga ctatagtcgg ttgcatggtt actttaagcg tggaatcaaa tggagtggca 240 tttagttcag gcggcttgtt ccttgccatg gcaaagtatc aagaagatcc ccaagtcaag 300 tcacatttgt aaagctgctt cccaattggc tttgtcacgc agtgttgaag cagtgggaga 360 gagattcacc tgttataaag gaactgacta acacaagtat cccgtctata tctgaatgct 420 gtctctaggt gtaagccgtg gtttcgcctt cgtggagttt tatcacttgc aagatgctac 480 cagctggatg gaagccaatc aggttgcttc actcaccaag tctagatatt catgaaaatg 540 gaacaagtct gtacaatttt aaaaaaaggt tgaaggagtg gtttgttcca aaggagtgac 600 ttttttttaa aaaaaaagct ttgtatatat taaaattgat gttactagaa taagtacagt 660 accaaggact tcattataga atttgttctg cctttaaaca tggctaccta cctggcaggg 720 ctttgttaac tactgaatac ctgtctggta atcactaaaa catcttaatg tttccctttt 780 ttctagtttg ttatattcct attatgtcca ttgagagtaa gcttagtata tcaaactctc 840 catttgaca g tgaagagaac atagtgaaag tctgtggcgg catttttata agtaattcct 900 tatttctgcc tgaagaccac aaagcctcct ggaggcgtaa ctgctcagac cggtcttcag 960 ggaatattta aggacttagt ggaatttatg aacaataagt ctgatgagat tagcctggga 1020 gtggtgtcct gcagctgtct aatctagagt ggcattaaca ttctaatctc cttgagaatg 1080 ccttttatag tctgttcaaa gcaagtcatt gatggttctt cgaggtagtg ttaactgaag 1140 tgttcttcag tttgtcaaga taatgttcag tgcttggcac ttaaataaca ttttttgcaa 1200 gaactccaag gcacattatt gaatgccttt aaccaagtgc attctgggaa gtttgcttga 1260 ctcattatct tgcttttctg cagcattctg tgatttgagt catccatgaa tccatgaata 1320 aaagttacat tctttgattg gtaatattgc catttataac aagactcact aatgagggta 1380 tcactttgac tgactgattt gttaaagttt ttaagcctct cattttccta acccagaaat 1440 cacagcctga ttttattaaa agtagagctt cattcatttc ataccataga taccatccta 1500 gtaaatccag aacatataca aggttcatgt gagtctgctt tcttgacatg atagcattgt 1560 ttgatgcagt ggatatgtca gaatgactaa cctaggagtt tgaaactcct aagaaactaa 1620 aacctgtaag acatttaaaa gtctccacaa ttttaatgta tacaaagcta tgttactgtg 1680 taacacatta cagttc aaat tcactccaga aataaaaggc cagtaggatt agggactcac 1740 tggtagtttg gagtctccca gcacacatcc ctcctagtgg gatgatctat tcacatatct 1800 cccagctttt ttatttttgc ttctgtatat cacagtgagt ggatggccct tcagcttttt 1860 ctctcctggc cagacatgca gtcttgcctt tagatatcgc agagacaaaa ttcacagcat 1920 gtcttaaatc ttccaggatt tgcaagaacc aaattgctca acagtatgta tgtttagagg 1980 ggttagactc ctttttaaaa tctggatatc taaccaccta cttaaatctg tttgatagtg 2040 tcaaaccacc cccacccttg atcctcccac ccccaagaaa aagaaaagat gctcctgtta 2100 aatgaaggct ctttaggggt aggtgctagg tatactcttg gctagattga ttcagctcag 2160 aattttgact ttttaaagct aagtccttgt agtcacatgg ttgacttgaa ggatgaggtg 2220 gtgtgtgcat ttatgagctt ttcctacccc cctgaagaaa cttcattggc ctcctggtta 2280 ctcaccttga agagagtacc atccatttta gtgaaaaaca catctgtcac ctaggacatg 2340 acatggttgc agttgacagg aaaaaaaaaa tctcatttag ttgttttaga gttggtggca 2400 ttcagaatag tccctcttga gaaagaattg taaccagatt ccctttaaaa atgagttccc 2460 ctccctttcc ccccaaagga ctcatcctga agcagaaggt gtggggggaa ggagaaatgt 2520 aaaggctttt actttgcata aggatggggg actggggaaa aaggtgaagc gaagcccaag 2580 gacaccatgc taagggcaaa agtaagagac agtctcagaa ctgagagaat tgtgtcttct 2640 gctttttgaa gtagactgtc acactcaggc agcctgtcaa tgctgaatgt taggacttct 2700 gtctccgctg gagacacggc ctggtgcaag tcagcgttta gtgtttgaca gctttctcag 2760 cactccctga ctccgtttac ctttactccg catcccattc tcttactgcc tatctgaagg 2820 attggatggg cagagtatag gtggcggtgg ttggtcctcc ccgtatgttg tccatttaat 2880 tccagagcac tgatttttcc gaagtgtgct ctgccctggg aaaatggaca catgttcctc 2940 acaatgggaa taactaa tta ctt ctt ttc tta cag aaa aag ttg gtg att 2990 Leu Leu Leu Phe Leu Gln Lys Lys Leu Val Ile 1 5 10 caa gga aag cac att gca atg cat tat agc aat ccc aga cct aag ttt 3038 Gln Gly Lys His Ile Ala Met His Tyr Ser Asn Pro Arg Pro Lys Phe 15 20 25 gaa gat tgg ctt tgt aac aag tgc tgc ctt aac aat ttc agg aaa aga 3086 Glu Asp Trp Leu Cys Asn Lys Cys Cys Leu Asn Asn Phe Arg Lys Arg 30 35 40 cta aaa tgc ttc cga tgt gga gca gac aag ttt gac tct gaa cag gaa 3134 Leu Lys Cys Phe Arg Cys Gly Ala Asp Lys Phe Asp Ser G lu Gln Glu 45 50 55 gtg cct cct gga acc aca gag tcg gtt cag tct gtg gat tac tac tgt 3182 Val Pro Pro Gly Thr Thr Glu Ser Val Gln Ser Val Asp Tyr Tyr Cys 60 65 70 75 gat acg atc att ctt cgg aac ata gct ccg cac act gtg gtg gat tcc 3230 Asp Thr Ile Ile Leu Arg Asn Ile Ala Pro His Thr Val Val Asp Ser 80 85 90 atc atg aca gca ctg tct cct tac gcg tct tta gct gtc aat aac atc 3278 Ile Met Thr Ala Leu Ser Pro Tyr Ala Ser Leu Ala Val Asn Asn Ile 95 100 105 cgc ctc ata aaa gac aaa cag acc cag cag aac aga ggc ttc gca ttt 3326 Arg Leu Ile Lys Asp Lys Gln Thr Gln Gln Asn Arg Gly Phe Ala Phe 110 115 120 gtg cag ctg tcc tct gca atg gat gct tct cag ctg ctt cag ata tta 3374 Val Gln Leu Ser Ser Ala Met Asp Ala Ser Gln Leu Leu Gln Ile Leu 125 130 135 cag agt ctc cat cct cct ttg aaa att gat ggc aaa act att ggg gtt 3422 Gln Ser Leu His Pro Pro Leu Lys Ile Asp Gly Lys Thr Ile Gly Val 140 145 150 155 gat ttt gca aaa agt gcc aga aaa gac ttg gtc ctc tca gat ggt aac 3470 Asp Phe Ala Lys Ser Ala Arg Lys Asp Leu Val Leu Ser Asp Gly Asn 160 165 170 cgc gtc agc gcc ttc tct gta gct agt acg gct att gct gct gct cag 3518 Arg Val Ser Ala Phe Ser Val Ala Ser Thr Ala Ile Ala Ala Ala Gln 175 180 185 tgg tca tcc acc cag tct caa agt ggt gaa gga ggc agt gtt gac tac 3566 Trp Ser Ser Thr Gln Ser Gln Ser Gly Glu Gly Gly Ser Val Asp Tyr 190 195 200 agt tat ctg caa cca ggt caa gat ggc tat gcc caa tat gct cag tat 3614 Ser Tyr Leu Gln Pro Gly Gln Asp Gly Tyr Ala Gln Tyr Ala Gln Tyr 205 210 215 tca cag gat tat cag cag ttt tat caa caa caa gct gga gga ttg gaa 3662 Ser Gln Asp Tyr Gln Gln Phe Tyr Gln Gln Gln Ala Gly Glu Leu Glu 220 225 230 235 tct gat gca tca tct gca tca ggc aca gca gtg acc acc acc tca gcg 3710 Ser Asp Ala Ser Ser Ala Ser Gly Thr Ala Val Thr Thr Thr Ser Ala 240 245 250 gct gta gtg tcc cag agt cct cag ctg tat aat caa acc tcc aat cca 3758 Ala Val Val Ser Gln Ser Pro Gln Leu Tyr Asn Gln Thr Ser Asn Pro 255 260 265 cct ggc tct ccg tac tac tat aat tcc ttg acc cag cag tac ctt tac 3806 Pro Gly Ser Pro Tyr Tyr Tyr Asn Ser Leu Thr Gln Gln Tyr Leu Tyr 270 275 280 tgg gat ggg gaa aaa gag acc tac gtg cca gct gca gag tct agc tcc 3854 Trp Asp Gly Glu Lys Glu Thr Tyr Val Pro Ala Ala Glu Ser Ser Ser 285 290 295 cac cag cag tcg ggc ctg cct cct gca aaa gag ggg aaa gag aag aag 3902 His Gln Gln Ser Gly Leu Pro Pro Ala Lys Glu Gly Lys Glu Lys Lys 300 305 310 315 gag aaa ccc aag agc aaa aca gcc cag cag att gcc aaa gac atg gaa 3950 Glu Lys Pro Lys Ser Lys Thr Ala Gln Gln Ile Ala Lys Asp Met Glu 320 325 330 cgc tgg gct aag agt ttg aat aag cag aaa gaa aac ttt aaa aat agc 3998 Arg Trp Ala Lys Ser Leu Asn Lys Gln Glu Asn Phe Lys Asn Ser 335 340 345 ttt cag cct gtc aat tcc ttg agg gaa gaa gaa agg aga gaa tct gct 4046 Phe Gln Pro Val Asn Ser Leu Arg Glu Glu Glu Arg Arg Glu Ser Ala 350 355 360 gca gca gac gct ttt gct ctc ttt gag aag aag gga gcc tta gct 4094 Ala Ala Asp Ala Gly Phe Ala Leu Phe Glu Lys Lys Gly Ala Leu Ala 365 370 375 gaa agg cag cag ctc atc cca gaa ttg gtg cga aat gga gat gag lu Arg Gln Gln Leu Ile Pro Glu Leu Val Arg Asn Gly Asp Glu Glu 380 385 390 395 aat ccc ctc aaa agg ggt ctg gtt gct gct tac agt ggt gac agt gac 4190 Asn Pro Leu Lys Arg Gly Leu Val Ala Ala Tyr Ser Gly Asp Ser Asp 400 405 410 aat gag gag gag ctg gtg gag aga ctt gag agt gag gaa gag aag cta 4238 Asn Glu Glu Glu Leu Val Glu Arg Leu Glu Ser Glu Glu Glu Lys Leu 415 420 425 gct gac tgg aag aag atg gcc tgt ctg ctc tgc cgg cgc cag ttc ccg 4286 Ala Asp Trp Lys Lys Met Ala Cys Leu Leu Cys Arg Arg Gln Phe Pro 430 435 440 aac aaa gat gcc cta gtc agg cac cag caa ctc tca gac ctt Lec Asag ApA Asla A334A Val Arg His Gln Gln Leu Ser Asp Leu His Lys 445 450 455 caa aac atg gac atc tac cga cga tcc agg ctg agc gag cag gag ctg 4382 Gln Asn Met Asp Ile Tyr Arg Arg Ser Arg Leu Ser Glu Gln Glu Leu 460 465 470 475 gaa gcc ttg gag cta agg gag aga gag atg aaa tac cga gac cga gct 4430 Glu Ala Leu Glu Leu Arg Glu Arg Glu Met Lys Tyr Arg Asp Arg Ala 480 485 490 gca gaa aga cgg gag aag tac ggc attca t cca gag ccc aag 4478 Ala Glu Arg Arg Glu Lys Tyr Gly Ile Pro Glu Pro Pro Glu Pro Lys 495 500 505 cgc aag aag cag ttt gat gcc ggc act gtg aat tac gag caa ccc acc 4526 Arg Lys Lys Gln Phe Asp Ala Gly Thr Val Asn Tyr Glu Gln Pro Thr 510 515 520 aaa gat ggc att gac cac agt aac att ggc aac aag atg ctg cag gcc 4574 Lys Asp Gly Ile Asp His Ser Asn Ile Gly Asn Lys Met Leu Gln Ala 525 530 530 atg ggc t cgg gaa ggc tct ggc ttg gga cga aag tgt caa ggc att 4622 Met Gly Trp Arg Glu Gly Ser Gly Leu Gly Arg Lys Cys Gln Gly Ile 540 545 550 555 555 acg gct ccc att gag gct caa gtt cgg cta aag gga gct 4670 Thr Ala Pro Ile Glu Ala Gln Val Arg Leu Lys Gly Ala Gly Leu Gly 560 565 570 gcc aaa ggc agc gca tat ggt ttg tcg ggc gcc gat tcc tac aaa gat 4718 Ala Lys Gly Ser Ala Tyr Gly Leu Ser Gly Ala Asp Tyr Lys Asp 575 580 585 gct gtc cgg aaa gcc atg ttt gcc cgg ttc act gag atg gag 4760 Ala Val Arg Lys Ala Met Phe Ala Arg Phe Thr Glu Met Glu 590 595 600 tgagagagag agagagagag agatgacaag gagcaaga agtggtccat ctcccgaatt 4820 cgctgttacc gcctgtctct ttaagggcat gccttgtgct gttaatagat cttagggtga 4880 accacttcat tctgcagggt tctccctccc accttaaaga agttcccctt atgtgggttg 4940 cctggtgaat ggccttcctt cccgccagag ggcttgtgaa cagaccggag aggacagtgg 5000 attgtttata ctccagtgta catagtgtaa tgtagcgtgt ttacatgtgt agcctatgtt 5060 gtggtccatc agcccctcac attcctaggg gtttgagatg ctgtaggtgg tatgtgacac 5120 caaagccacc tctgtcattt gttgtgatgt cttttcttgg caaaagcctt gtgtatattt 5180 gtatattaca catttgtaca gaattttgga agattttcag tctagttgcc aaatctggct 5240 cctttacaaa agaaatacct tgag 5264 <210> 174 <211> 4801 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (65) .. (3409) <400> 174 gagaaatccc aggggtggat gaggcaccta gctggtgccc gcctgcaggc tgctcgcttg 60 ctga gag gcg gcg tgc cag ctc cgc gca ccg cgc ctc agt gcc aga tca 109 Glu Ala Ag Lag Ag Ag Ag Ag Ag Ag Ag cag ctc agc gcc cac gcc cct ccg ctt cag ctc cgg gga 157 Gly Ser Cys Gln Leu Ser Ala His Ala Pro Pro Leu Gln Leu Arg Gly 20 25 30 gcc cca ggg tgg gct gct gga agg cgc gac tgc aac ttg act ttg c205 Ala Pro Gly Trp Ala Ala Gly Arg Arg Asp Cys Asn Leu Thr Leu Pro 35 40 45 cac tgt tgt tgc tgg cag aat acg tac acc aat gcg gac aag ctc cta 253 His Cys Cys Cys Trp Gln Asn Thr Tyr Thr Asn Ala Asp Lys Leu Leu 50 55 60 gaa gca gca gag cag ttg gct cag acg ggg gaa tgt gac ccc gag gag 301 Glu Ala Ala Glu Gln Leu Ala Gln Thr Gly Glu Cys Asp Pro Glu Glu 65 70 75 atc tac aag gca gct cga cac ctg gag gtg cgc atc caa gac ttc gtg 349 Ile Tyr Lys Ala Ala Arg His Leu Glu Val Arg Ile Gln Asp Phe Val 80 85 90 95 cgc agg gtg gag cag cgg aag ctt ctc ctg gac atg tct gtt tcc ttc 397 Arg Ar g Val Glu Gln Arg Lys Leu Leu Leu Asp Met Ser Val Ser Phe 100 105 110 cac aca cac acc aaa gag ttg tgg aca tgg atg gaa gac ctt cag aag 445 His Thr His Thr Lys Glu Leu Trp Thr Trp Met Glu Asp Leu Gln Lys 115 120 125 gag atg ttg gag gat gtc tgt gca gat tct gtg gat gca gtc cag gaa 493 Glu Met Leu Glu Asp Val Cys Ala Asp Ser Val Asp Ala Val Gln Glu 130 135 140 ctg atc aaa cag ttc cag cag cag acc gcc act cta gat gcc aca 541 Leu Ile Lys Gln Phe Gln Gln Gln Gln Thr Ala Thr Leu Asp Ala Thr 145 150 155 ctc aat gtc atc aag gaa ggc gaa gac ctt atc cag cag ctc agg gac 589 Leu Asn Val Ile Glu Lys Glu Lys Glu Asp Leu Ile Gln Gln Leu Arg Asp 160 165 170 175 tcg gct gtg tcc aac aac aaa aca ccc cac agc agc tcc atc agc cac 637 Ser Ala Val Ser Asn Asn Lys Thr Pro His Ser Ser Ser Ile Ser His 180 185 190 atc gag tcg gtc ctg cag cag ctt gat gat gcc cag gtg cag atg gag 685 Ile Glu Ser Val Leu Gln Gln Leu Asp Asp Ala Gln Val Gln Met Glu 195 200 205 gag ctg ttc cac gag cgg aag atc aag ctg gac atc ttgc atc ag ctg gac atcctg 733 Glu Leu Phe His Glu Arg Lys Ile Lys Leu Asp Ile Phe Leu Gln Leu 210 215 220 cgc atc ttt gag cag tac acc atc gag gtg aca gca gag cta gac gcc 781 Arg Ile Phe Glu Gln Tyr Thr Ile Glu Val Thr Ala Glu Leu Asp Ala 225 230 235 tgg aat gaa gac ttg ctt cgg cag atg aat gac ttc aac aca gag gac 829 Trp Asn Glu Asp Leu Leu Arg Gln Met Asn Asp Phe Asn Thr Glu Asp 240 245 250 255 cta acc ctg gcagaa cgg ctg cag cgc cac aca gaa cgg aag cta 877 Leu Thr Leu Ala Glu Gln Arg Leu Gln Arg His Thr Glu Arg Lys Leu 260 265 270 gcc atg aac aac atg acc ttt gag gtt atc cag cag gga cag gat ctg Aset Asn Met Thr Phe Glu Val Ile Gln Gln Gly Gln Asp Leu 275 280 285 cac cag tac atc acg gag gtc cag gca tca gga att gag ttg atc tgt 973 His Gln Tyr Ile Thr Glu Val Gln Ala Ser Gly Ile Glu Leu Ile Cys 290 295 300 gaa aaa gac att gat ctg gca gcc cag gtg caa gag tta ttg gaa ttt 1021 Glu Lys Asp Ile Asp Leu Ala Ala Gln Val Gln Glu Leu Leu Glu Phe 305 310 315 ctc cat gag aag cag cat gaa ttggg a gag cag act cat 1069 Leu His Glu Lys Gln His Glu Leu Glu Leu Asn Ala Glu Gln Thr His 320 325 330 335 aag cgg cta gag cag tgc ctc caa tta cgt cac ctc cag gct gaa gtc 1117 Lys Arg Leu Glu Gln Cys Leu Gln Leu Arg His Leu Gln Ala Glu Val 340 345 350 aaa cag gtt ctg gga tgg atc cgc aat gga gag tca atg ctc aac gcc 1165 Lys Gln Val Leu Gly Trp Ile Arg Asn Gly Glu Ser Met Leu Asn Ala 355 360 365 agc ct gtc aat gcc agc tct ttg tcg gaa gca gag cag ctg cag cgg 1213 Ser Leu Val Asn Ala Ser Ser Leu Ser Glu Ala Glu Gln Leu Gln Arg 370 375 380 gag cac gag cag ttc caa ctg gcc atc gag tcc gcc catc ctc ttt 1261 Glu His Glu Gln Phe Gln Leu Ala Ile Glu Ser Leu Phe His Ala Thr 385 390 395 tcc ttg cag aag acg cac cag agt gcc ctg cag gta cag cag aaa gcc 1309 Ser Leu Gln Lys Thr His Gln Ser Ala Leu Gln Val Gln Gln Lys Ala 400 405 410 415 gag gtg ctg ctc cag gcc ggc cac tac gat gcc gat gcc atc cgg gaa 1357 Glu Val Leu Leu Gln Ala Gly His Tyr Asp Ala Asp Ala Ile Arg Glu 420 425 430 430 tgt gct gag aag gtg ctc cac tgg cag cag ctc atg ctg aag atg 1405 Cys Ala Glu Lys Val Ala Leu His Trp Gln Gln Leu Met Leu Lys Met 435 440 445 gaa gac cgg cta aaa ttg gtc aat gcc tct gtg gcc ttt tac aaa act 1453 Leu Lys Leu Val Asn Ala Ser Val Ala Phe Tyr Lys Thr 450 455 460 tct gaa cag gtg tgt agt gtc ctg gag agc tta gag caa gaa tac cgg 1501 Ser Glu Glu Val Cys Ser Val Leu Glu Ser Leu Glu Gln Glu Tyr Arg 465 470 475 aga gat gag gac tgg tgt ggt gga cga gat aag ctg ggg cca gca gca 1549 Arg Asp Glu Asp Trp Cys Gly Gly Arg Asp Lys Leu Gly Pro Ala Ala 480 485 490 490 495 gag atc gac cat gtc att ccc c ctc atc cat ttg gaa caa aag 1597 Glu Ile Asp His Val Ile Pro Leu Ile Ser Lys His Leu Glu Gln Lys 500 505 510 gag gcc ttt ctt aag gcc tgc acc ctg gct cgg cgg aat gct gag gtg 1645 Glu Ala Phe Leu Lys Ala Cys Thr Leu Ala Arg Arg Asn Ala Glu Val 515 520 525 ttt ctc aag tac atc cac agg aac aac gtc agc atg ccc agt gtc gcc 1693 Phe Leu Lys Tyr Ile His Arg Asn Asn Val Ser Met Pro Ser Val Ala 530 535 535 540 agc cac act cgg gga ccc gag caa caa gtg aaa gcc atc ctg agt gag 1741 Ser His Thr Arg Gly Pro Glu Gln Gln Val Lys Ala Ile Leu Ser Glu 545 550 555 ctc ctg cag agg gag aat cgc gtg ctg cat ttc tgg acctt aag 1789 Leu Leu Gln Arg Glu Asn Arg Val Leu His Phe Trp Thr Leu Lys Lys 560 565 570 575 cgg cgg tta gac caa tgc cag caa tat gtg gtg ttc gag cgc agc gct 1837 Arg Arg Leu Asp Gln Cys Val Gln Gln Phe Glu Arg Ser Ala 580 585 590 aag cag gcg ctt gac tgg atc caa gaa aca ggt gaa ttt tac ctc tca 1885 Lys Gln Ala Leu Asp Trp Ile Gln Glu Thr Gly Glu Phe Tyr Leu Ser 595 600 605 aca cat acc tcc act gga gag acc aca gag gag act cag gaa ctg ctg 1933 Thr His Thr Ser Thr Gly Glu Thr Thr Glu Glu Thr Gln Glu Leu Leu 610 615 620 aaa gaa tat ggg gaa ttc agg gtg cct gcc aag caa aca aag gag aag 1981 Lys Glu Tyr Gly Glu Phe Arg Val Pro Ala Lys Gln Thr Lys Glu Lys 625 630 635 gtg aag ctt ctg att cag ctg gcc gat agc ttt gtg gaa aaa ggc cac 2029 Val Lys Leu Leu Ile Gln Leu Ala Asp Ser Phe Val Glu Lys Gly His 640 645 650 655 att cat gcc acg gag ata agg aaa tgg gtg acc acg gtg gac aag cac 2077 Ile His Ala Thr Glu Ile Arg Lys Trp Val Thr Thr Val Asp Lys His 660 665 670 tac aga gat ttc tcc ctg agg atg gga aag tac cga tac tca ctg gag 2125 Tyr Arg Asp Phe Ser Leu Arg Met Gly Lys Tyr Arg Tyr Ser Leu Glu 675 680 685 aaa gcc cta gga gtc aac aca gag gat aat aag gac ctg gag ctg gat 2173 Lys Asla Leu Gly Thr Glu Asp Asn Lys Asp Leu Glu Leu Asp 690 695 700 att atc cca gca agc ctt tcg gat cgg gag gtc aag ctg cgg gac gcc 2221 Ile Ile Pro Ala Ser Leu Ser Asp Arg Glu Val Lys Leu Arg Asp Ala 705 710 715 a cac gaa gtc aat gaa gag aag cgg aag tca gcc cgg aag aaa gaa 2269 Asn His Glu Val Asn Glu Glu Lys Arg Lys Ser Ala Arg Lys Lys Glu 720 725 730 735 ttt att atg gct gaa cta ctc cag aca gag gag gag agg gat 2317 Phe Ile Met Ala Glu Leu Leu Gln Thr Glu Lys Ala Tyr Val Arg Asp 740 745 750 ttg cat gag tgc tta gag acc tac ctg tgg gaa atg acc agt ggt gtg 2365 Leu His Glu Cys Leu Glu Thr Tyr Leu Trp Glu Met Thr Ser Gly Val 755 760 765 gag gag atc ccc cct ggg atc ctc aat aaa gag cat atc atc ttt ggc 2413 Glu Glu Ile Pro Pro Gly Ile Leu Asn Lys Glu His Ile Ile Phe Gly 770 775 780 aac atc caa gag atc tac gat ttc cat aac aac atc ttc ctc aaa gag 2461 Asn Ile Gln Glu Ile Tyr Asp Phe His Asn Asn Ile Phe Leu Lys Glu 785 790 795 ctg gag aag tac gag caa ctg cct gag gat gtg tga tgc tgc tgc Glu Lys Tyr Glu Gln Leu Pro Glu Asp Val Gly His Cys Phe Val 800 805 810 815 acc tgg gca gac aaa ttt cag atg tat gtc acc tac tgt aaa aac aag 2557 Thr Trp Ala Asp Lys Phe Gln Met Tyr Val Thr Tyr Cys Lys Asn Lys 820 825 830 cct gat tcc aac cag ctt atc ctg gag cat gcg ggc acc ttc ttt gat 2605 Pro Asp Ser Asn Gln Leu Ile Leu Glu His Ala Gly Thr Phe Phe Asp 835 840 845 gag ata caa cag cgg cat ggt ctg g aac tcc atc tct tcc tac cta 2653 Glu Ile Gln Gln Arg His Gly Leu Ala Asn Ser Ile Ser Ser Tyr Leu 850 855 860 att aag cct gtc caa agg atc acc aaa tat caa ctg ctc ctg aag gaa 2701 Ile Lys Pro Val G ln Arg Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu 865 870 875 ctt tta act tgc tgt gaa gaa ggg aaa ggg gag ctc aag gat ggc ctg 2749 Leu Leu Thr Cys Cys Glu Glu Gly Lys Gly Glu Leu Lys Asp Gly 890 895 gag gtg atg ctc agt gtc cca aag aaa gcc aat gat gcc atg cat gtc 2797 Glu Val Met Leu Ser Val Pro Lys Lys Ala Asn Asp Ala Met His Val 900 905 910 agc atg ctg gaa ggg ttc gac gag aacgtg cag ggg gag ttg 2845 Ser Met Leu Glu Gly Phe Asp Glu Asn Leu Asp Val Gln Gly Glu Leu 915 920 925 att ctc cag gat gcc ttt caa gtg tgg gac ccg aag tcg ctg atc cgg 2893 Ile Leu Gln Asp Ala Phe Asp Pro Lys Ser Leu Ile Arg 930 935 940 aag ggg cgg gag cgg cac ttg ttc ctc ttt gag atc tcc ttg gtt ttt 2941 Lys Gly Arg Glu Arg His Leu Phe Leu Phe Glu Ile Ser Leu Val Phe 945 950 955 atgc aag aaa gat tct tca gga cac acg aaa tat gtt tac aag 2989 Ser Lys Glu Ile Lys Asp Ser Ser Gly His Thr Lys Tyr Val Tyr Lys 960 965 970 975 aac aag cta ctg acc tca gag ctg ggt gtg acc gag cac gtg gag gg c 3037 Asn Lys Leu Leu Thr Ser Glu Leu Gly Val Thr Glu His Val Glu Gly 980 985 990 gat ccc tgc aaa ttc gcc ttg tgg tct ggg cgc acc cca tcc tca gac 3085 Asp Pro Cys Lys Phe Ala Leu Trp Ser Gly Arg Thr Pro Ser Ser Asp 995 1000 1005 aat aaa aca gtg ctg aaa gcc tcc aac att gaa acc aag cag gag tgg 3133 Asn Lys Thr Val Leu Lys Ala Ser Asn Ile Glu Thr Lys Gln Glu Trp 1010 1015 1020 atc aag aac att cga gaa gtg att caa gaa agg atc att cac ctg aaa 3181 Ile Lys Asn Ile Arg Glu Val Ile Gln Glu Arg Ile Ile His Leu Lys 1025 1030 1035 gga gct tta aag gag cca ctt cag ctc ccc aaa aca cca gcc aaa cag 3229 Gly Ala Glu Pro Leu Gln Leu Pro Lys Thr Pro Ala Lys Gln 1040 1045 1050 1055 agg aac aat agt aag agg gat gga gtg gag gat att gac agc cag ggg 3277 Arg Asn Asn Ser Lys Arg Asp Gly Val Glu Asp Ile Asp Ser Gln Gly 1060 1065 1070 gat ggg agc agc caa cca gac acc atc tcc att gct tct agg acc tct 3325 Asp Gly Ser Ser Gln Pro Asp Thr Ile Ser Ile Ala Ser Arg Thr Ser 1075 1080 1085 cag aac aca gtg gac agt gac aag gat ggc aac ctt gtt cct cgg tgg 3373 Gln Asn Thr Val Asp Ser Asp Lys Asp Gly Asn Leu Val Pro Arg Trp 1090 1095 1100 cac ctg gga cct gga gat cct ttc tcc act tac gtt tagcgcgcat 3419 His Leu Gly Pro Gly Pro Phe Ser Thr Tyr Val 1105 1110 1115 cctgggactt gtccctgcag ctcaccgggt tagccgtggc accgttggga cctcccacca 3479 ggactccaat cacccacctc tcttgagact tctctggcag ggctggtgtg gggtgcagcc 3539 tttgctcaga gggcaacatg ttccaagcaa aatctccccg cctgggccat gggctcaccc 3599 tcggggctcc cttcttctct actgggtgca attcgaggtt gctgagcttc tctccaaagt 3659 ctaaaatggt ggggcagtag ggacctgtga gaggcccaat ggcccaatgt acttccccca 3719 gatcccactc agaacagcag gtacgcccag gctcctgctg ccctagaggt ctgcaacatg 3779 agtgaagagg ttaattagag ggacacactt atctctgaag tttttctcca ggctgaacat 3839 ttctattatc agtggcccct aatctggaaa aacccatcat tctaatctag cttgtatccc 3899 cacatcatga gaaagaggga agaagaagaa gggatgatgt gtggtagaga agatgagggt 3959 taactttagc ctttcccaaa cactggcaac aaccacttcc tcaacaattt ttctatttgc 4019 ttcagcctac tcagattttt tcaggttttt ctagc tcctc cataacctca ctccctcccg 4079 aggtctctgg ttcaaagacc accctaccag cccctatttg cttcaggtta tcctgttgag 4139 ggtgggtggg aagagtgaga agatataaat gaaaaactgg ccacatgttg ataattgttg 4199 aaactagatg atggtacgtg gacattcatt ataccattct ccccacttct gtatttgttt 4259 gcaatttttc ataataaaaa agttttaaaa gtcctccagt ttccaacaca ctcaagagag 4319 agccccaacc ccaaacacag agtttcatgg aaaccccaca ccaaggcaag aggcagagat 4379 gatgattcca tttcatatat acactcattt tctaactttt tttaaaggcc cactgcttta 4439 ttttcaatag attaaacctg atttctgaga ggtcctgaag ttgggcttat ttccctggct 4499 gggttatggg ggagggcagg gtaaagggat ccttaaaaaa gtttacactt ctatgtatct 4559 cacaatctta ttgtgaggat gtgacttgtt cagtgttctg aacttttcga aggaatcgtg 4619 ctctcaatgc aaagtgtcat tctctggaat tgcacctggc tcaggaaagg actgtctttg 4679 tacttgaatt taaatccaat ggagaacttt aacacgggca tttgcatgac tgagaattgc 4739 tgctgtcttt tttccgtatg tcactttctt gaatgtgttc taataaaatg attctaaagc 4799 ag 4801 <210> 175 <211> 5206 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2125) <400> 175 c aga aag cca gcc ctc cct tcc ctt ctt ggg gcg cag agg ctc agc cag 49 Arg Lys Pro Ala Leu Pro Ser Leu Leu Gly Ala Gln Arg Leu Ser Gln 1 5 10 15 ctc aga gcg cag cct gga gcc gac cca gaa ggg cga aga aag ccc agc 97 Leu Arg Ala Gln Pro Gly Ala Asp Pro Glu Gly Arg Arg Lys Pro Ser 20 25 30 gga cga gcc tcc ttt ctc tgc tgc ctg ccc ggg ctg ggg cgt ccc atc 145 Gly Arg Ala Phe Leu Cys Cys Leu Pro Gly Leu Gly Arg Pro Ile 35 40 45 ccc cgc cct gaa ctc cga tct ctc cca ccc cac ccc tct ctg ggt ttc 193 Pro Arg Pro Glu Leu Arg Ser Leu Pro Pro His Pro Ser Leu Gly Phe 50 55 60 acc cgg aca gag ccg gga gct ggg tgt cgc ccc cgt ttg gaa tcc acg 241 Thr Arg Thr Glu Pro Gly Ala Gly Cys Arg Pro Arg Leu Glu Ser Thr 65 70 75 80 ttt cag cac ttt gga cag cgc ccc gga cgc ccc ggc ccc ttt ggg ttg 289 Phe Gln His Phe Gly Gln Arg Pro Gly Arg Pro Gly Pro Phe Gly Leu 85 90 95 gcg atg gcg agc gtt cag caa ggc gag aag cag ctt ttt gag aag ttc 337 Ala Met Ala Ser Val Gln Gln Gly Glu Lys Gln Leu Phe Glu Lys Phe 100 105 110 tgg cga gga acc ttc aaa gcg gtg gcc acc ccc cgt ccc gag agc atc 385 Trp Arg Gly Thr Phe Lys Ala Val Ala Thr Pro Arg Pro Glu Ser Ile 115 120 125 att gtc gcc agt atc acg gcc cgc aag ccg ctg cca agg aca gag ccc 433 Ile Val Ala Ser Ile Thr Ala Arg Lys Pro Leu Pro Arg Thr Glu Pro 130 135 140 cag aat aac ccc gtt gtc cca gct cag gat gga ccc tca gaa aag ctg 481 Gln Asn Asn Pro Val Val Pro Ala Gln Asp Gly Pro Ser Glu Lys Leu 145 150 155 160 ggt cag cat ctg gcc acc gag ccc ttg ggc acc aac agt tgg gag aga 529 Gly Gln His Leu Ala Thr Glu Pro Leu Gly Thr Asn Ser Trp Glu Arg 165 170 175 gac aag acc tgt cgg gaa ctg ggt gcc acc aga gga cac agt gcc tct 577 Asp Lys Thr Cys Arg Glu Leu Gly Ala Thr Arg Gly His Ser Ala Ser 180 185 190 cat gac aaa gac ttg aca cca cca cct tcc tcc agg gga aag aag aaa 625 His Asp Lys Asp Leu Thr Pro Pro Pro Ser Ser Arg Gly Lys Lys Lys 195 200 205 aag aag aaa tcc act cgg aag aag aga agg agg tcc tca tcc tat agc 673 Lys Lys Lys Ser Thr Arg Lys Lys Arg Arg Arg Ser Ser Ser Tyr Ser 210 215 220 cca tcg cct gtc aag aaa aag aag aag aaa agt tcc aag aaa cac aag 721 Pro Ser Pro Val Lys Lys Lys Lys Lys Lys Lys Ser Ser Lys Lys His Lys 225 230 235 240 cga cgc agg tca ttc tcc aag aag aga agg cac agc tcc tct agc cca 769 Arg Arg Arg Ser Phe Ser Lys Lys Arg Arg His Ser Ser Ser Ser Pro 245 250 255 aaa agc aaa aga aga gat gag aag agg cac aag aaa caa tct cga agc 817 Lys Ser Lys Arg Arg Asp Glu Lys Arg His Lys Lys Gln Ser Arg Ser 260 265 270 cgg ccc cga aag tct cac cgc cac cgc cat cac cgc tgc ccc tcg cgg 865 Arg Pro Arg Lys Ser His Arg His Arg His His Arg Cys Pro Ser Arg 275 280 285 tcc cag agc tcg gag tcc cgc ccc tca agc tgt gag agc agg cac cgc 913 Ser Gln Ser Ser Glu Ser Arg Pro Ser Ser Cys Glu Ser Arg His Arg 290 295 300 ggc cgg tcc cct gag gaa ggg cag aag tcc cgc cga agg cac cgc 961 Gly Arg Ser Pro Glu Glu Gly Gln Lys Ser Arg Arg Arg His Ser Arg 305 310 315 320 cgc tgc tcc aag acc ctc tgc aag gac agc cct gag gcc cag tcc agt 1009 Arg Cys Ser Lys Thr Leu Cys Lys Asp Ser Pr o Glu Ala Gln Ser Ser 325 330 335 cgc ccg ccc agt caa ccc ctc cag atg ctt ggc tac ctg tca gcc agg 1057 Arg Pro Pro Ser Gln Pro Leu Gln Met Leu Gly Tyr Leu Ser Ala Arg 340 345 350 350 ggt gta atc act ggg tcg ggg tct gct gct gac ctc ttt acc aaa aca 1105 Gly Val Ile Thr Gly Ser Gly Ser Ala Ala Asp Leu Phe Thr Lys Thr 355 360 365 gcc agc ccg ctc acc acc tcg cga gga cgt tcc cag gag tac gac tca 1153 Ala Ser Pro Leu Thr Thr Ser Arg Gly Arg Ser Gln Glu Tyr Asp Ser 370 375 380 gga aat gac acg tcc tcg cca ccc tcc acg caa acc agc tca gcc agg 1201 Gly Asn Asp Thr Ser Ser Pro Pro Ser Thr Gln Thr Ser Ser Ala Arg 385 390 395 400 tct cgg ggc cag gag aag ggg agc ccc agt ggg ggc ttg agc aag agc 1249 Ser Arg Gly Gln Glu Lys Gly Ser Pro Ser Gly Gly Leu Ser Lys Ser 405 410 415 cgg gag ctc aac agt ggc aac acct tca ggg aac tcc ttc acc 1297 Arg Glu Leu Asn Ser Gly Asn Thr Ser Asp Ser Gly Asn Ser Phe Thr 420 425 430 acc tcc tca ccc cag aac aag ggg gcc atg ttg gag aat ctc tcc ccc 1345 Thr Ser Ser Pro Gln As n Lys Gly Ala Met Leu Glu Asn Leu Ser Pro 435 440 445 acc agc agg ggc aga gag tca agg gga ttt cag tca ccg tgt ctg gaa 1393 Thr Ser Arg Gly Arg Glu Ser Arg Gly Phe Gln Ser Pro Cys Leu Glu 450 455 460 tgt gcc gaa gtg aag aag tcc agt ttg gtc cca tcc aca gcc cgg agc 1441 Cys Ala Glu Val Lys Lys Ser Ser Leu Val Pro Ser Thr Ala Arg Ser 465 470 475 475 480 tca ccc atg aaa ggg tgt tcc cgc agc tcc tcc tat agc acc cga 1489 Ser Pro Met Lys Gly Cys Ser Arg Ser Ser Ser Tyr Ala Ser Thr Arg 485 490 t495 tcc tcc agt cac tcg tcc cga tcc cca aat ccc agg gct tcc ccc agg 1537 Ser Ser Ser Ser His Ser Ser Arg Ser Pro Asn Pro Arg Ala Ser Pro Arg 500 505 510 tac acc caa agc cga tcc acc tct tct gaa aaa agg tcc tac tcc cgc 1585 Tyr Thr Gln Ser Arg Ser Thr Ser Ser Glu Lys Arg Ser Tyr Ser Arg 515 520 525 tct ccc agc tat tcc tcc aag tct ggc aag agg agc ccg ccc agc aga 1633 Ser Pro Ser Tyr Ser Ser Lys Ser Gly Lys Arg Ser Pro Pro Ser Arg 530 535 540 agc tct agg tcc cgc cgc agc cct agc tac tcc cgc tac agc ccc agc 1681 Ser Arg Ser Arg Arg Ser Pro Ser Tyr Ser Arg Tyr Ser Pro Ser 545 550 555 560 agg gag cgg gat ccc aaa tac agt gag aag gac tcg cag cag cgg gag 1729 Arg Glu Arg Asp Pro Lys Tyr Ser Glu Lys Asp Ser Gln Gln Arg Glu 565 570 575 cgc gag cga gcg cgt cgg aga cgt cgg tcc tac tcg cct atg aga aag 1777 Arg Glu Arg Ala Arg Arg Arg Arg Arg Serg Tyr Ser Pro Met Arg Lys 580 585 590 cgc cgg aga gac tcc ccg ag gag gcc cgg agg ata acc agt 1825 Arg Arg Arg Asp Ser Pro Ser His Leu Glu Ala Arg Arg Ile Thr Ser 595 600 605 gcc cgg aaa cgc ccc atc ccc tac tat cgg ccc agc ccc tcc tca tcc 1873 Ala Arg Lys Arg Pro Ile Pro Tyr Tyr Arg Pro Ser Pro Ser Ser Ser Ser 610 615 620 ggc agc ctc agc agc acc tcc tcc tgg tac agc agc agc agt agc cgc 1921 Gly Ser Leu Ser Ser Thr Ser Ser Trp Tyr Ser Ser Ser Ser Ser Arg 625 630 635 640 tcg gcc agc cgc agc tac tcc cgg agc tgg agt cgg agc cgg agc cgg 1969 Ser Ala Ser Arg Ser Tyr Ser Arg Ser Trp Ser Arg Ser Arg Ser Arg 645 650 655 655 aga cgg agc cgg acc cgc acg agc agc agc tct cc cgc agc cct 2017 Arg Arg Ser Arg Thr Arg Thr Ser Ser Ser Ser Ser Ser Arg Ser Pro 660 665 670 agt ccg ggc tcc cgc agc cgg agc cgg agc agg agc cgg agc cgg agc 2065 Ser Pro Gly Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser 675 680 685 cgg agc agg agc cag agc cgg agc tac agc tca gca gac agc tac tcc 2113 Arg Ser Arg Ser Gln Ser Arg Ser Tyr Ser Ser Ala Asp Ser Tyr Ser 690 695 700 agc acg agg cgc taagtgcccc tgagccagct gcccgtgggg gccccttcgc 2165 Ser Thr Arg Arg 705 gctgccagcc tcccccaacc acctgccctc cccgccttct tggtgacaaa tagtgagggc 2225 tcctatacct tgtccttcct gcttgcctag gggaagagga gaagagggta agggggcttc 2285 actctctaga tcagcctgct aggagcctct accagcatca tcctggggcc cagctcaggc 2345 ctgggcatat ggaaagaacc atcatcttgt ggcacaaaaa aagaagaaag aaaagaaaac 2405 ttcaaggttt tgtgagaagc aatgggtctg tgactcaaaa attgagccct ggccaggaaa 2465 atgtggagac agttcttctc ctccactgct cacaggaggc ccgtggtaat tctccccacc 2525 tccccggatg ccccactagt ccaacttcat ggctgcacgt ggatggaccc ccatgtctga 2585 gaggggtgaa agaggagacc aatggcagt t caggttcaag ataacggggt caggccttta 2645 acttcctcaa acaggcccaa gcaaaggctg gaagacattt gggtcctaga agaagggata 2705 tccttgaata ccagatgggg acgtttgact tggtgggagg tgtcaggaga taggagttgg 2765 ttaagatgat agatagaaaa acggaagggt tcagctgctg ctcccaatac ctcagcatgg 2825 taaggggaca gagcccagca gatcccagct gtgaagaggc cactgcatgg ctgacacaaa 2885 acacctcttg gccattcaca ggggccctgc aacctcacga gaaaggagat agtggaagag 2945 tcaggacagg ttggtctcca gccccacttc ccaaatatgc ctcagcccca ctagctggca 3005 ccaacttaat tccacgggac catctgctga acattcccca gtgccatggc cagttgccag 3065 gccccagcgc cagccagtct ggccttaccc tccggttggc gcctgccagc cccctcccct 3125 ctgcccaggc tgccacgccc tggatgccac ccagtgcagc ctggcaccta cccacccacc 3185 cttcagctta agccactccc cttgcctctc aggaattttg ccaggatggg gcacagcagc 3245 tcaggtttgg gggaaaagac ccgaatccag agtgcagggg agaggggctt ggatatgcca 3305 tgtcttgggc tcctgctggc ttctgaggtt tcttgtcagc ttgggaaaga cccaccttta 3365 tttttgccct caccccaagt cccccctggc tggggctggg cagagagggt aagctgatct 3425 ccgatccaca aataccacca gctgcttcat ccac agaagg cgctaagaac ggggaggtga 3485 ggaataagat ccttaaaata aactcttggg catccccctc accagctgac tggctttccg 3545 gaggcttgtg ggtgagtttc aagtttgtgg tggcaacagc agcaggacag ggcacggagg 3605 gagcgaggga gagaggaccg gtcccagctt ttggatattt tgggttatgg ggaagcaagg 3665 gccaaacatt ctttatccct cccaccccag ggaaaacatt tggaaaatag tcctttttct 3725 tggaagcagt gacgtctccc tacccaatct ttcccatcct atcaacccat ggggctagag 3785 actgccatgc aaccaccacc acgacagccc ttcctccatc agaagacagg agtgagggcc 3845 ccgggcagca gtggacgacc cagcctcccc ataccgggcc tctggcccag acctaagccc 3905 tgcccacaaa gactaatgga tgccagtgct gtcactgcag aaggccagat ggcaggtgcc 3965 tgggacaggg gcaggtgccc cggggagggc aagtacagcc actgtaaata accctcgtcc 4025 ctgcccagga acccagactg gacttcagtc tccctccatg gagacaaagg cttcccagag 4085 ccaccaaaaa ccttcttagc aggacagctg tgagaggcat cagaacctca cgttcggact 4145 gccttcatca agacaactct aggggaccat tttgcctggg gctcctagca aaccttttta 4205 tttattttat ttatttatct atttatttat ttgatgactg tctctctttc tcgccattag 4265 cagtattgaa ttatttattt atacagaggt tttgtgtgt g tgtgtgtgtg tgtgtgtgtg 4325 tgtgtgtgtg tgtgtgttgg ggggatctcc taaattattt ctgtgcatct cctttttttt 4385 tctgctgttt tttatggatg ggatttgaga ggccaaaggt gagtgggcta ttggccttct 4445 ccctgaaggc tctaagcctg gaacaccctg gggttggccc agaaggaggc acatcagtcc 4505 caaaattcat cacttaaccc agcgtccagg agggtcaggc ctgtacccca gcctcctgtc 4565 ccccaggaac ctcacagggg tatcaaaaag atgtaaacag cccagaggct tatgagctac 4625 agtgatgaat tgacacagtg gagttgcaac ttaggtgggg gttggagtcg aaagttggca 4685 aatggggcca aggctgcaca aagtcgaaat cccttgtgaa tgtcccttag ggaggcacca 4745 gattggagac agatgtgcta tctcctaaca gagtgatgag gcttcagttg agtacttgct 4805 gaagtagttg ccttgtattt tgagggccat ggtggatgaa aatgatgtct ggtttagtac 4865 tggaattgca cttggggttg acaaggtgct cacaccatga gaatggaggc aggaattgag 4925 ctgactgagg gaagatgcac cttgatctca ccctcactcc aaggcacata gcaggatcac 4985 tccctagctt ctctgagcac acctagttgg tttcatgtat gttacacatg cttccactcc 5045 acagtaccta atttctctct gtcccctgag atctgaaggc taccttggga agaggcatca 5105 gccatcttgc ttgagaacca ccaagccaaa agcaaaagct ttta tctatg atctcttgct 5165 gtttcatcag gggaaagcac aaagctattt ctgaaattag g 5206 <210> 176 <211> 4651 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2351) <400> 176 tc caa aga caa atc acc cag gaa tgt gag tta gtt gaa acc agt aat 47 Gln Arg Gln Ile Thr Gln Glu Cys Glu Leu Val Glu Thr Ser Asn 1 5 10 15 tct gag gac aga tta ttg aag cac tgg gta agc cct tta aag gat gca 95 Ser Glu Asp Arg Leu Leu Lys His Trp Val Ser Pro Leu Lys Asp Ala 20 25 30 atg aga cat ctc cct tcc caa gag agc ggt atc agg gaa atg cat att 143 Met Arg His Leu Pro Ser Gln Glu Ser Gly Ile Arg Glu Met His Ile 35 40 45 atc ccc cag aaa gcc att gtg gga gag att ggc cat gga tgt aat gaa 191 Ile Pro Gln Lys Ala Ile Val Gly Glu Ile Gly His Gly Cys Asn Glu 50 55 60 gga gaa aaa ata ctt tct gca gga gaa agc tcc cat aga tat gag gtt 239 Gly Glu Lys Ile Leu Ser Ala Gly Glu Ser Ser His Arg Tyr Glu Val 65 70 75 agt ggc caa aac ttc aaa cag aag tca gga tta act gaa cat cag aaa 287 Ser Gly Gln Asn Phe Lys Gln Lys Ser Gly Leu Thr Glu His Gln Lys 80 85 90 95 att cat aat ata aat aag acc tat gaa tgt aag gaa tgt gaa aaa acc 335 Ile His Asn Ile Asn Lys Thr Tyr Glu Cys Lys Glu Cys Glu Lys Thr 100 105 110 ttc aac agg agt tca aac ctg atc ata cat cag aga att cat aca gga 383 Phe Asn Arg Ser Ser Asn Leu Ile Ile His Gln Arg Ile His Thr Gly 115 120 125 aat aag cca tat gtg tgt aat gaa tgt ggg aaa gac tct aat caa agt 431 Asn Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Asp Ser Asn Gln Ser 130 135 140 tca aat ctt att ata cat cag aga att cat aca gga aag aaa cct tat 479 Ser Asn Leu Ile Ile His Gln Arg Ile His Thr Gly Lys Lys Pro Tyr 145 150 155 ata tgt cat gaa tgt gga aaa gac ttc aat cag agc tcc aat ctg gtg 527 Ile Cys His Glu Cys Gly Lys Asp Phe Asn Gln Ser Ser Asn Leu Val 160 165 170 175 aga cat aag caa att cac agt ggt ggg aat ccc tat gag tgc aaa gag 575 Arg His Lys Gln Ile His Ser Gly Gly Asn Pro Tyr Glu Cys Lys Glu 180 185 190 tgt ggg aag gct ttt aag gga agc tca aac ctt gtc ctg cac cag aga 623 Cys Gly Ala Phe Lys Gly Ser Ser Asn Leu Val Leu His Gln Arg 195 200 205 atc cac agt agg ggg aag cca tat tta tgc aat aaa tgt ggg aag gct 671 Ile His Ser Arg Gly Lys Pro Tyr Leu Cys Asn Lys Cys Gly Lys Ala 21 0 215 220 ttc agt caa agc aca gat ctt att ata cat cac aga att cac act gga 719 Phe Ser Gln Ser Thr Asp Leu Ile Ile His His Arg Ile His Thr Gly 225 230 235 gag aaa ccc tat gaa tgt tat gac tgt gga cag atg ttc agt caa agt 767 Glu Lys Pro Tyr Glu Cys Tyr Asp Cys Gly Gln Met Phe Ser Gln Ser 240 245 250 255 tca cac ctt gtc cca cat cag aga att cac act gga gag aaa ccc ctc 815 Ser His Leu Val Pro His Gln Arg Ile His Thr Gly Glu Lys Pro Leu 260 265 270 270 aaa tgt aat gaa tgt gaa aaa gcc ttc agg cag cat tct cac ctt act 863 Lys Cys Asn Glu Cys Glu Lys Ala Phe Arg Gln His Ser His Leu Thr 275 280 280 285 gaa cac cag aga ctc cac agt gga gag aaa ccc tat gaa tgt cac aga 911 Glu His Gln Arg Leu His Ser Gly Glu Lys Pro Tyr Glu Cys His Arg 290 295 300 tgt ggg aag acc ttc agt ggg cgc aca gct ttt ctt aaa cat cag aga 959 Cys Gly Lys Thr Phe Ser Gly Arg Thr Ala Phe Leu Lys His Gln Arg 305 310 315 ttg cat gct gga gag aaa att gaa gaa tgt gag aaa acc ttc agc aag 1007 Leu His Ala Gly Glu Lys Ile Glu Glu Cys Glu Lys Thr P he Ser Lys 320 325 330 335 gat gag gag ctt agg gaa gag cag aga att cac cag gaa gag aaa gct 1055 Asp Glu Glu Leu Arg Glu Glu Gln Arg Ile His Gln Glu Glu Lys Ala 340 345 350 tat tgg tgt aat cag tgt ggt agg aat ttc cag ggc acc tca gac ctc 1103 Tyr Trp Cys Asn Gln Cys Gly Arg Asn Phe Gln Gly Thr Ser Asp Leu 355 360 365 atc aga cat cag gta act cat aca gga gag aaa cca tat gaa tgt aaa 1151 Ile Arg His Gln Val Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 370 375 380 gaa tgt ggg aaa act ttc aat cag agc tca gac ctt ctg aga cat cat 1199 Glu Cys Gly Lys Thr Phe Asn Gln Ser Ser Asp Leu Leu Arg His His 385 390 395 aga att cac agt gga gaa aaa cct tgt gta tgt agc aaa tgt ggg aaa 1247 Arg Ile His Ser Gly Glu Lys Pro Cys Val Cys Ser Lys Cys Gly Lys 400 405 410 415 tct ttt agg ggc agc tca gat ctt att aga cac cat cgt gtt cat act 1295 Ser Phe Arg Gly Ser Ser Asp Leu Ile Arg His His Arg Val His Thr 420 425 430 gga gag aaa ccc tat gaa tgt agt gaa tgt ggg aaa gcc ttt agc cag 1343 Gly Glu Lys Pro Tyr Glu Cys S er Glu Cys Gly Lys Ala Phe Ser Gln 435 440 445 agg tca cac ctt gtt aca cac cag aaa atc cat act gga gag aag ccc 1391 Arg Ser His Leu Val Thr His Gln Lys Ile His Thr Gly Glu Lys Pro 450 455 460 tat cag tgc act gaa tgt ggg aaa gcc ttc agg cgg cgt tca ctc ctt 1439 Tyr Gln Cys Thr Glu Cys Gly Lys Ala Phe Arg Arg Arg Ser Leu Leu 465 470 475 att caa cat cgg aga att cat agt ggt gag aaa ccc ag tag 1487 Ile Gln His Arg Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Lys 480 485 495 gaa tgt ggg aag ctc ttc att tgg cgc aca gct ttc ctc aaa cat cag 1535 Glu Cys Gly Lys Leu Phe Ile Trp Arg Thr Ala Leu Lys His Gln 500 505 510 agc ctg cat act gga gag aaa ctt gaa tgt gag aaa acc ttc agc cag 1583 Ser Leu His Thr Gly Glu Lys Leu Glu Cys Glu Lys Thr Phe Ser Gln 515 520 525 gat gaa gag ctt agg gga gag cag aaa att cac cag gaa gcg aaa gct 1631 Asp Glu Glu Leu Arg Gly Glu Gln Lys Ile His Gln Glu Ala Lys Ala 530 535 540 tat tgg tgt aat cag tgt ggt agg gct ttc cag ggc agc tca gac ctc 1679 s Asn Gln Cys Gly Arg Ala Phe Gln Gly Ser Ser Asp Leu 545 550 555 atc aga cat cag gta act cat aca aga gag aaa cca tat gaa tgc aaa 1727 Ile Arg His Gln Val Thr His Thr Arg Glu Lys Pro Tyr Glu Cys Lys 560 565 570 575 gaa tgt ggg aaa act ttc aat cag agc tca gac ctt ctg aga cat cat 1775 Glu Cys Gly Lys Thr Phe Asn Gln Ser Ser Asp Leu Leu Arg His His 580 585 590 590 aga att cac agt gga gaa aaa cct tat gta tgc aac aaa tgt ggg aaa 1823 Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys Asn Lys Cys Gly Lys 595 600 605 tct ttt agg ggt agc tca gat ctt att aaa cac cat cgt att cat act 1871 Ser Phe Arg Gly Ser Ser Asp Leu Ile Lys His His Arg Ile His Thr 610 615 620 gga gag aaa ccc tat gaa tgt agt gaa tgt ggg aaa gcc ttc agc cag 1919 Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln 625 630 635 agg tca cac ctt gct aca cac cag aaa atc cat act gga gag aaa ccc 1967 Arg Ser His Leu Ala Thr His Gln Lys Ile His Thr Gly Glu Lys Pro 640 645 650 655 tat cag tgc agt gaa tgt ggg aat gcc ttc agg cgg cgt tcc ctc ctt 2015 Tyr Gln Cys Ser Glu Cys Gly Asn Ala Phe Arg Arg Arg Ser Leu Leu 660 665 670 att caa cat cgg aga ctt cat agt ggt gag aaa ccc tat gaa tgt aag 2063 Ile Gln His Arg Arg Leu His Ser Gly Glu Lys Pro Tyr Glu Cys Lys 675 680 685 gaa tgt ggg aaa ctc ttc atg tgg cac acg gct ttc ctc aaa cat cag 2111 Glu Cys Gly Lys Leu Phe Met Trp His Thr Ala Phe Leu Lys His Gln 690 695 700 aga ctg cat gg gga aaa ctt gaa gaa tgt gag aaa acc ttc agc 2159 Arg Leu His Ala Gly Glu Lys Leu Glu Glu Cys Glu Lys Thr Phe Ser 705 710 715 aag gat gag gag ctt aga aaa gag cag aga act cac cag gaa aag aaa 2207 Lys As Glu Leu Arg Lys Glu Gln Arg Thr His Gln Glu Lys Lys 720 725 730 735 gtt tat tgg tgt aat cag tgt agt agg acc ttc cag ggc agc tca gat 2255 Val Tyr Trp Cys Asn Gln Cys Ser Arg Thr Phe Gln Gly Ser Ser Asp 740 745 750 ctc atc aga cat cag gta act cat aca aga gag aaa cca tat gaa tgt 2303 Leu Ile Arg His Gln Val Thr His Thr Arg Glu Lys Pro Tyr Glu Cys 755 760 765 765 aaa gaa tgt ggg aaa act caa tca gag ctc aga cct tct gag aca tca 2351 Lys Glu Cys Gly Lys Thr Gln Ser Glu Leu Arg Pro Ser Glu Thr Ser 770 775 780 tagaattcac agtggagaaa aaccttacgt atgcaataaa tgtggggaat cttttaggag 2411 cagctcagat cttattaaac accatcgtgt tcatactgga gagaaacctc atgaatgtag 2471 tgaatgtggg aaagtcttta gccagaggtc ccaccttgtc acacaccaga aaatccacac 2531 tggagagaag ccctatcagt gcactgaatg tgaaaaagcc ttcaggcggc gttcactcct 2591 tattcaacgt cggagaattc atagtggtga gaaaccctat gaatgtaagg aatgtgggaa 2651 actcttcatg tggcacacag ctttcctcaa acatcagaga ctgcatgctg gagagaaact 2711 tgaagaatgt gagaaaacct tcagcaagga tgaggagctt aggggagagc agaaaattca 2771 ccaagaagag aaagcttatt ggtgtaatca gtgtggtagg gctttccagg gcagctcaga 2831 cctcatcgga catcaggtaa ctcatacagg agagaaacca tatgaatgta aagaatgtgg 2891 gaaaactttc aatcagagct cagaccttct gagacatcat agaattcaca gtggagaaaa 2951 accttatgta tgcaacaaat gtgggaaatc ttttaggggc agctcagatc ttattagaca 3011 ccatcgtgtt catactggag agaaacccta tgaatgccct gaatgttgga aggccttcag 3071 tcagaactca caccttgtca gtcatcaaag aattc atacc agagagaaac cctttgaatg 3131 tagcaactgt ggtaaggcct tcagtgggtg gacagctttt cttaagcacc agaaacttca 3191 cattggaaag gaatttgaag actgtaagag tctacaaaca ggacctattc taataggtag 3251 cagaaaccta atgaatgcag taaaactagg aaaagtctga tggagaccac atcttattgc 3311 actacaaatg agttttatta gaaaaaaacc atgggaaggt gggaaagcag agaaaatacc 3371 tactggattt ttcaaacgta agtataatca agtggaaaag ccaaaagctc ttggacataa 3431 tcaccttttt tttttctgtc tcagaactga cactagaata tggtcccaac gatacaattt 3491 tttaaattat ttatttttta acatacaaag agatgaggtc tcactatgtt gcccaggctg 3551 gacttgaact cttgggctca agcactcctc cctcctcagc ctcccaaagg gttgggatta 3611 ccggcatgag ccactgcacc agccccaggg gtctaattac ttgagaatgt tttaagggat 3671 gtctatcatt attaaaatca ttataaatca ctttggcaac aaccccaaaa ctaaattatt 3731 catggaaaga gccatttcaa tcttgacttc ctagtcgagt gacaagttta aatgtgggaa 3791 aaaaccctgt gaaagtaatg agtgtaggcc aggtgcggtg gcttgtacct gtaatccagc 3851 actttgggaa gccaaggtgg gcagatcacg aggtcacgag ttgatcatga ggagttacta 3911 tgcccagcca acatactaaa accccgtctc tactaaaaat aacaaaaatt agccaggcat 3971 ggtggggcac gcctgtagtc ccaggtactt gcgaggctag ggcaggagaa tcacttgaac 4031 ctgggaggtg gaggttgcgg tgagccaaga tcatgccact gcactccagc ctgggcaaca 4091 agtgcgaaac tccatctcaa aaaaaaaaaa aagtctaact cttctgcttg tctttacaat 4151 gctgtacagt gagagctaat gtttataagg ataaacagga tacttacagg gatttgaagg 4211 taatttaatt cagtggtttc caacttttta atcaccaagg ccttcttttt actcccctat 4271 gtcctgtgtc ttaaaagatt atgtttacca aactgcattt attaaagaat tatattttgc 4331 tacataaagg catgtacaac acaaatcatg cttctgactg gcaccatgta ggcagaccta 4391 ggtactaaaa ttccagccca aagcaaataa tttaccattt tcattagtct ttttattcct 4451 tttgtgggca aacatatcgt ctatgttagg ctttttgaaa tattaactat gacttgtaaa 4511 ctccagatta aaaactaacc aattcatctt tgatggagct tgaatcaaac taagggtatt 4571 ggacttttga aagattgaaa tttttgttac agtatggaat gtttttaact gaatgttgaa 4631 ataaaagtta tttaagaatt 4651 <210> 177 <211> 4976 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (404) .. (1489) <400> 177 ggaagccgag cctctgccag ccctgagctg ggaagaagca gctacctcgg aggcagggcg 60 cgcaggcggg cggcgatgag agggggcgca gccgcagccc cgcgctgggg agcccaccgc 120 taaccctgca ccccacccac ccctgcacaa aagagctggc gggcgctggc cacgtcgccc 180 tgggtgacct tcctcggatg cagaatccgc ccctgcgagc atcctcttcc tcctaggctc 240 tgaaggcccg gggagcgtga gcgatgccca gctgcacccg ggcagggctc gcctttgttt 300 gccagtaagg aggagaggct gtctcagctg cagaggggtc atccctgctt caagccagtg 360 cctcttccca gctcccatgg ggaccaccga agccacgctc cgg atg gaa aac gtg 415 Met Glu Asn Val 1 gac gtg aag gag gaa tgg cag gac gaa gat ctt ccc agg cca ctc cca 463 Asp Val Lys Glu Glu Trp Gln Asp Glu Asp Leu Pro Arg Pro Leu Pro 5 10 15 20 gaa gag acg ggg gtg gaa ctg ctt ggc agc ccg gtg gaa gac aca tcc 511 Glu Glu Thr Gly Val Glu Leu Leu Gly Ser Pro Val Glu Asp Thr Ser 25 30 35 tct cct ccc aac acg cta aat ttc aac gga gc ag cag aag 559 Ser Pro Pro Asn Thr Leu Asn Phe Asn Gly Ala His Arg Lys Arg Lys 40 45 50 acg ctg gtg gcc cca gag atc aac att tct ctg gat cag agt gag ggg 607 Thr Leu Val Ala Pro Glu Ile Asn Ile Ser Leu Asp Gln Ser Glu Gly 55 60 65 tcc ctg ctg tcc gat gac ttc ttg gat acc cct gat gac ctg gat att 655 Ser Leu Leu Ser Asp Asp Phe Leu Asp Thr Pro Asp Asp Leu Asp Ile 70 75 80 aac gtg gat gac atc gag acc ccc gat gag acc gac tcg ctg gag ttc 703 Asn Val Asp Asp Ile Glu Thr Pro Asp Glu Thr Asp Ser Leu Glu Phe 85 90 95 100 ctg ggg aat ggc aac gaa ctg gag tgg gaa gac gac acc ccc gtg gcc 751 Leu Gly Asn Gly Asn Glu Leu Glu Trp Glu Asp Asp Thr Pro Val Ala 105 110 115 acc gcc aag aac atg ccc ggg gac agc gcg gat cta ttt ggg gac ggc 799 Thr Ala Lys Asn Met Pro Gly Asp Ser Ala Asp Leu Phe Gly Asp Gly 120 125 130 acg acg gag gac ggc agc gcc gcc aac ggg cgc ctg tgg cgg aca gtg 847 Thr Thr Glu Asp Gly Ser Ala Ala Asn Gly Arg Leu Trp Arg Thr Val 135 140 145 atc atc ggg gag caa gag cac cgt ata gac ctg cac atg atc cgg cct 895 Ile Ile Gly Glu Gln Glu His Arg Ile Asp Leu His Met Ile Arg Pro 150 155 160 tac atg aaa gtg gtc acc cac gga ggg tac tac ggc gaa ggc ctc aac 943 Tyr Met Lys Val Val Thr His Gly Gly Tyr Tyr Gly Glu Gly Leu Asn 165 170 175 180 gcc atc atc gtc ttc gca gcc tgc ttc ctt cca gac agc agc ctc ccc 991 Ala Ile Ile Val Phe Ala Ala Cys Pro Asp Ser Ser Leu Pro 185 190 195 gac tac cac tac atc atg gag aac ctc ttc ctg tac gtc atc agc agc 1039 Asp Tyr His Tyr Ile Met Glu Asn Leu Phe Leu Tyr Val Ile Ser Ser 200 205 210 tta gag ctc ctg gtg gct gag gac tac atg atc gtg tac ctg aac ggt 1087 Leu Glu Leu Leu Val Ala Glu Asp Tyr Met Ile Val Tyr Leu Asn Gly 215 220 225 gcc acg ccc cgg cgg agg atg cct gga atc ggc tgg ctg aag Aag tgc 1135 Pro Arg Arg Arg Met Pro Gly Ile Gly Trp Leu Lys Lys Cys 230 235 240 tac cag atg atc gac cgg agg ttg cgg aaa aac ctg aag tcc ttg atc 1183 Tyr Gln Met Ile Asp Arg Arg Leu Arg Lys Asn Leu Lys Ser Leu 245 250 255 260 atc gtc cac ccc tcg tgg ttc att cgg act gtg ctg gcc atc tct cgc 1231 Ile Val His Pro Ser Trp Phe Ile Arg Thr Val Val Leu Ala Ile Ser Arg 265 270 275 cct ttc atc agc gtc aag ttc atca c aag atc cag tac gtg cac agc 1279 Pro Phe Ile Ser Val Lys Phe Ile Asn Lys Ile Gln Tyr Val His Ser 280 285 290 ttg gaa gac ctg gag caa ctc atc cct atg gaa cac gtc cag atc cca 1327 Leu Glu Asp Gln Leu Ile Pro Met Glu His Val Gln Ile Pro 295 300 305 gac tgc gtc ctg caa tac gaa gag gaa aga ctg aag gcc agg agg gag 1375 Asp Cys Val Leu Gln Tyr Glu Glu Glu Arg Leu Lys Ala Arg Arg Glu 310 310 agc gcg agg ccc cag ccg gag ttt gtg ctg ccc agg tct gaa gag aag 1423 Ser Ala Arg Pro Gln Pro Glu Phe Val Leu Pro Arg Ser Glu Glu Lys 325 330 335 340 cca gag gtg gca cca gtg gaa aac agg tct tca gaa gat 1471 Pro Glu Val Ala Pro Val Glu Asn Arg Ser Ala Leu Val Ser Glu Asp 345 350 355 cag gaa aca agc atg tcc tgaggcgacg tgagcataac aaaggacatg 1519 Gln Glu Thr Ser Met Ser 360 gaagaagatt ccagatccc ccagatgcc ccagatccc ccagatcccg ccagatgcctccc gcc ggtgccagcc cctccgttca tctctgaaac 1639 ccagcatcct tttcagctgc ttgaaaacat tgtatttttt ttttaacgat gcagtatttg 1699 tgcgttccag aaaagggccc agctctgagc ccctcaccct tccacactca cgaactctca 1759 gccgaggaag gcaagaagcg cagggggtgg cccgcgtggc gtcggtggcc tccgctcctg 1819 ctcgcagccc ctgtggtcag agctggatac aagattcaag acccttctct tgcttgtcac 1879 ccgctccagg ttggagccac agacacccac cgccaccccg gctgggtctg cctcctttcc 1939 tgtgcctttc cctccagaat gcggcctcag acctagaagc tcaacccccc tatgagggcc 1999 acgtcctggg gtagctcctg acctccgacc ttatgtccaa atttcacacc catggttttt 2059 catttgaccc gcccccttct cgctcataat gacacccagc tcctttgaga ggatcagagc 2119 ccattgcaca agaagagccg ctgccaacca tccttgtcct ccgattgcaa aatgacaccc 2179 cagtaatcta gaacattctc aagccccttt aactcagatg tcaagccacc gggcaaaccc 2239 cgtcaatacc tcccaccaag gaatgagata tgtggacctc actgctcccc caacccagcg 2299 tcaggctggg acatgccaac gctgttccgg gttggaacag cagaggctca gaaactggct 2359 cggaaatagg cagacctagc aagaggaaga tacagggtat cgggcgtttg agtgtttcag 2419 aagtcattcg ggaagataaa tccagtgcgc tggccgcagc cacctgcatt caaagcttgg 2479 accagcgggt tcttgttcgg gaggcaaatt tccctaggaa aaagaagaca gacttttcta 2539 atgtgg tcca aatgcggatc actggtcaga tggactctag aagcactgag ctccctgtct 2599 ctggaagtat ttaagaaaag gctgggccag gcacgatggc tcacgcctgt aatcccagac 2659 tttgggaggc cgaggcaggc ggatcacctg aggtgaggag tttgagaaca gcctggccaa 2719 catggtgaaa cctcatctct actaaaaata caaaaattag ccaggcgtgg tggcaggtgc 2779 ctgtaatccc agctacttgg gaggctgagg catgagaatc acttaaacct gagaggcaga 2839 ggttacagtg agccaagatc gtgccactgc attccagcct gggcgacaga gcaagactct 2899 gtctcaaaaa aaataaaaaa taatcagggc acagtggctc atgcctgtaa tcccagcact 2959 ctgggaggct gaggtgggtg gatcacctga ggtcaggagt tcaagaccag cctggtgaac 3019 atggcgaaac cccgtctcta ataaaaatac aaaaattagc cgggcatggt ggtgcatgcc 3079 tgtaatccca gctactcggg aggctgaggc aggagaactg cttgaaccca ggaggcagag 3139 gttgcagtga tccaagatca tgccactgca ctccagcctg ggcaacaaga gcaaaactcc 3199 gtctcaaaat aaaaagaaaa gaaaagaatg gacagtgttt gcagagagtt gctcacgagt 3259 ttccctctaa tcctaaatgt cttcatgtct atcagtctga gcagacggtg agtagggcgg 3319 gcacattctc caggcccttc ttcctagctc tgtggttgac ctctcagcaa gtgctatcca 3379 ggctgggcca accagaccca caattaactg agcctcagtg aaagcgtcca gtgcatcttg 3439 acctgagaca gcaaggaatt gcatttgggg ttattccaac gatgatggca gggaactggt 3499 ggtatttagt gctgaggggc agtgatacag aaagatttgc cctgtgggac agggtcctgc 3559 gcgagtccca tccccaaaag ccagcagctc ctgccatgag gaagacgggg tttctgagca 3619 ggcttatgcc tgcaggttcc tgtggagcca ccggctgtga cgggacacct ctgggtctca 3679 gcattgccct ggggaggctg ggacatttag ggacatggta gggttttaac atttgtttcc 3739 caaatgtcaa atcccgggca caggggcaag accctgtccc gaattcccac cccagtgaat 3799 ggtgtcgctg ccaaagccaa cacaagatga caaaagtggc tgggtacggt ggctcacgcc 3859 tataatccca gcactttggg agaccgagac aggtggatca cctgaggtca ggagttcgag 3919 accaggctgg ccaacatggt gaaaccccat ctctactaaa aatacaaaaa ttagctgggt 3979 gtggtggcgc gcacctgtag tcccagctac tcaggaggct gaggtagaag aatagctgga 4039 acccaggagg cagagattgc agtcagccga gattgcgcca ctgcactcca gcctgggaga 4099 cagagcaaga ctgactcaaa agaaaaaaaa tgacagaagc ctgattatca gactgcccgg 4159 aggagacagg ctccagcaga tagatgccag ccaggcccag ctgccacgat ttgtcccagg 4219 tgaccaaagg cacgca gctc cagcatgaat cgttctaacc caacagtgac aagaactgct 4279 gggccttaac cgtcatggaa gactggggcc gcttccaagt cacagacagg agacggggac 4339 aggaaagaac tcattccacc caatcggaca cctaataatt gagtgtctac agcagcaatc 4399 aagtgacaag tgaggcccta cctgacccag aaggtgcctg ccggctaaac attctgcccc 4459 caccagaaac tccagggggt ccgcccgtta tgccgtggcc cacccacgcc cctttggatc 4519 accagcagtc acagacaaca ggcaggcgaa actgaagacc ccaactcagc cccagcggac 4579 cctccagagc aaaagaggcc cccggcgagg ccacctgtcg gcaggcatgc cgaggtcaaa 4639 cagccggggc caccgttccc agctgggcca caacctgcac cgtccacaga tgggctttga 4699 gatggatttg tatcagggtg gggggtgtgg tttggccaaa atgcaatgga ccccgacccc 4759 tcctcgtaaa aggatgttgg gtttccctct ggtgacacat gggatgcgtc ataaaccctc 4819 ccccaaagtc ctggtcagca gcccatcctt ccaacgatga gttttgcggt ttttcagaac 4879 agaaatgatc actacgattg acgacggtcg tgatgttaag acgtcgtctc catgagcttt 4939 ggggggactt ttatgtggaa taaagaaact atcactg 4976 <210> 178 <211> 4981 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1641) <400> 178 cac aaa acc acc atc tcg gac ctg gct tac tgc gag gaa gta gag gca 48 His Lys Thr Thr Ile Ser Asp Leu Ala Tyr Cys Glu Glu Val Glu Ala 1 5 10 15 atg gtg aca gct tcc cgg gac agc acc gtg aag gtg tgg gag gct gac 96 Met Val Thr Ala Ser Arg Asp Ser Thr Val Lys Val Trp Glu Ala Asp 20 25 30 tgg cag atc cgg atg gtg ttc gtg ggc cac aca ggc ccg gtg acg gct 144 Trp Gln Ile Arg Met Val Phe Val Gly His Thr Gly Pro Val Thr Ala 35 40 45 atg act gtg ctc ccg aac acg acc ctg gtg ttg tcg gcc tcg cag gac 192 Met Thr Val Val Leu Pro Asn Thr Thr Leu Val Leu Ser Ala Ser Gln Asp 50 55 60 ggg acg cta cgc acc tgg gac ctg cag gcg gcg gcg cag gtg ggc gag 240 Gly Thr Leu Arg Thr Trp Asp Leu Gln Ala Ala Ala Gln Val Gly Glu 65 70 75 80 gta gcg ctg ggc ttc tgg ggc cag gac agg cg cg gc ag cg gc ag cg g gtg ggc 288 Val Ala Leu Gly Phe Trp Gly Gln Asp Lys Leu Ser Arg Arg Val Gly 85 90 95 cgt ctg ctg gcg ccg gtg cgc ccg ggc tgg ccg gtg ctg tcc ctg tgc 336 Arg Leu Leu Ala Pro Val Val Val Leu Ser Leu Cys 100 105 11 0 gcg agc agc atg cag ctg tgg cgc gta cgc gag ctc tac tcg ccg ttg 384 Ala Ser Ser Met Gln Leu Trp Arg Val Arg Glu Leu Tyr Ser Pro Leu 115 120 125 gcg caa ctg ccc gcc aag gtg gtc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gg ccc gcg ttg 432 Ala Gln Leu Pro Ala Lys Val Leu His Val Gln Val Ala Pro Ala Leu 130 135 140 ccc gcg cct gcg cac cag tcg ctg cct acg cgc ctc gtg tgc gcg tgc 480 Pro Ala Pro Ala His Gln Ser Leu Pro Thr Arg Leu Val Cys Ala Cys 145 150 155 160 gcc gac ggc tcg gtc tac ctc ctg tcg gct gcc acc ggg cgc ata gtg 528 Ala Asp Gly Ser Val Tyr Leu Leu Ser Ala Ala Thr Gly Arg Ile Val 165 170 175 agc tg ctg ctg gag ccg gag gac tgc gcg gca gcc gtg gcc tac 576 Ser Ser Leu Leu Leu Glu Pro Glu Asp Cys Ala Ala Ala Val Ala Tyr 180 185 190 tgc ctg ccg cgc gag gcg ctg tgg ctg ctg acc agg gct g Leu Pro Arg Glu Ala Leu Trp Leu Leu Thr Arg Ala Gly His Leu 195 200 205 gtc cgc gcc aac gcg gcg cgc tgc ccc atg agc gtg ctg cac cgc gtg 672 Val Arg Ala Asn Ala Ala Arg Cys Pro Met Ser Val V al 210 215 220 tgc ccg ccg ccg ccc cct gcg ccg cag cct tgc tgt ctg cac ctg tac 720 Cys Pro Pro Pro Pro Pro Ala Pro Gln Pro Cys Cys Leu His Leu Tyr 225 230 235 240 agc cac ctc acg gat ctc gga gc ttc tcc tcc tgg gag atc gtg 768 Ser His Leu Thr Asp Leu Gly Gly Ala Phe Ser Ser Trp Glu Ile Val 245 250 255 cgc cag cac tgg ggc gag ttg cgc tgc agc tct gtg gcc tgc gcc tgg 816 Arg Glu His Trp Leu Arg Cys Ser Ser Val Ala Cys Ala Trp 260 265 270 aag aac aag aac cgg tac ctg cca gtg gtg ggg cac acg gac ggc acg 864 Lys Asn Lys Asn Arg Tyr Leu Pro Val Val Gly His Thr Asp Gly Thr 275 280 285 ctg tcg gtg ctg gag tgg ctc tcg tcg aag act gtc ttc caa acg gag 912 Leu Ser Val Leu Glu Trp Leu Ser Ser Lys Thr Val Phe Gln Thr Glu 290 295 300 gcg cac agc ccg ggc ccg gtt gtc gcc atc gca tcc agc 960 Ala His Ser Pro Gly Pro Val Val Ala Ile Ala Ser Thr Trp Asn Ser 305 310 315 320 att gtg tct tcg ggt ggg gac ctg acg gtg aag atg tgg cgc gtc ttc 1008 Ile Val Ser Ser Gly Gly Asp Leu Thr Val Lys Met Trp Arg Val Phe 325 330 335 ccc tat gcc gaa gag agc ctg agc ctg ctg cgc acc ttc tcc tgc tgc 1056 Pro Tyr Ala Glu Glu Glu Ser Leu Ser Leu Leu Arg Thr Phe Ser Cys Cys 340 345 350 tac gg gcc gt tgt gcg cta ggc aga cgc gtc acc gcg ggc 1104 Tyr Pro Ala Val Ala Leu Cys Ala Leu Gly Arg Arg Val Thr Ala Gly 355 360 365 ttt gag gac cca gac agc gct acc tac ggc ctg gtg cag ttt ggc ctg 115p Pro Asp Ser Ala Thr Tyr Gly Leu Val Gln Phe Gly Leu 370 375 380 ggc gac agt ccg cga tta gac cac cgg ccc cag gac gac ccc acg gac 1200 Gly Asp Ser Pro Arg Leu Asp His Arg Pro Gln Asp Asp Pro Thr Asp 385 390 395 400 cac atc act ggc ctg tgc tgc tgc ccc acg ctc aaa ctg tat gcc tgc 1248 His Ile Thr Gly Leu Cys Cys Cys Pro Thr Leu Lys Leu Tyr Ala Cys 405 410 415 tcc agc ctg gac tgc acc gttc act gct gag aac cgc ctc 1296 Ser Ser Leu Asp Cys Thr Val Arg Ile Trp Thr Ala Glu Asn Arg Leu 420 425 430 ctg cgg ctc ctg cag ctg aat ggt gcc cct cag gcc ctg gct ttc tgc 1344 Leu Arg Leu Leu Gln Asn Gly Ala Pro Gln Ala Leu Ala Phe Cys 435 440 445 agc aac agt gga gac ctg gtg ctg gcg ctg gga tcc cgc ctc tgc ctg 1392 Ser Asn Ser Gly Asp Leu Val Leu Ala Leu Gly Ser Arg Leu 455 tcc cac agg ctc tac ctg cct aca tcc tac cta gtt aag aag atg 1440 Val Ser His Arg Leu Tyr Leu Pro Thr Ser Tyr Leu Val Lys Lys Met 465 470 475 475 480 tgc cgg aag gcc cca gac gtg gtg gac gac cct ccc gc ctg atg 1488 Cys Arg Lys Ala Pro Asp Val Val Asp Asp Pro Pro Leu Pro Leu Met 485 490 495 agc cag gag tca ctg act tcc gcc caa ctg cag agg ctc acc aac ctc 1536 Ser Gln Glu Ser Leu Thr Ser Ala Gln Leu Gln Arg Leu Thr Asn Leu 500 505 510 cat ggg gca gcc agc ctc agg tcc cat gca ggc ctg ctc agc cct cct 1584 His Gly Ala Ala Ser Leu Arg Ser His Ala Gly Leu Leu Ser Pro Pro 515 520 525 gga ggc cct cct ttcca ctc tgg gtg ggg gcc tgg cgg tgt ggg gcc 1632 Gly Gly Pro Pro Phe Pro Leu Trp Val Gly Ala Trp Arg Cys Gly Ala 530 535 540 ctc tgg agt tgatacaagc ctgcctgagc cctggcacac ccgtttgggg 1681 Leu Trp Ser 545 ttggtccttg tcccagcctc tgccccagcc cactggcatg ccacccagca tcccacctgt 1741 gcctgtccct gtttgcagcg aggccttgtc tctcatccat cgtcggaggg caacatctca 1801 gcacctggtg ccgaaggagg tggggtgggt cctccttagc ccgccctgcc ccggctcagg 1861 ccccagccgt cagccctggg gcaggcctgg gatccccatg gttgcccggg cagcacatag 1921 caaggctcaa ggaagagcag gctgatccct gaaccctgac tcaggacttg gacgccatag 1981 tggcccggga ccgagacctt cagcagttga ggctggggct agtggtccca gcagcccagc 2041 ccccaccctc ctggcagcag cgccaggaag gctttgacaa ttacctccgt ctgatctacg 2101 gctctggcct gctgggcatg cagtctggaa gggggtccca gcagtggagt gccgggaccc 2161 tcagagtgga gagagagacc cgggatgtgt gtgctgtacc ccaagctgcc cactgtcttg 2221 cccgggctga ggtcagcact gcagcccaaa cagtgccaac agccctgtcc ccacaggacc 2281 tgggagccct gggccagcac ttctcccagt ctccccgagt cacagtgccg atcccaccca 2341 cccaccgtag ggtgcacagc aaggcatccc agcttctggc ccgctcctca ctgagccact 2401 acctgggcat cagtctggat ctgcagctgc agttggagca gctccgaggg aggacgacca 2461 tggccctgga cctgccatcc tcccacttgc agtgcaggat cccactgctg ccaaagagat 2521 gg gacaagga acctctctct agcctcaggg gcttctttcc tgccaccgtg cagccccaca 2581 agcactgcct gaggcccatc tgcttccccg gctatgtgcc caactccgcg gtgctacagc 2641 agatgtggct aaatgcggag ccaggggcaa gccaggatgc cctgtggttg tggcgcccca 2701 ggccatccca agcccagtgg cagaggaagc tgctccaatg gatgggggag aagcctgggg 2761 aggaggggga ggaagacaag aaggaagagg aggaggagaa ggaagacgag gagcttgact 2821 gggccttggc ttccctgagc ccgcactcca accagcagct ggattcctgg gaactggagg 2881 atcagagtgc tgtggactgg acccaggagc cccggcggcg cagctgcaag gttgccagga 2941 cccaccctca tccctggcac cgtcatggga gtttgctctt ggatgagcat tacgggcatc 3001 tgcccaagtt tctgcatttc ttcatctacc agacctggtt caaaaagttg ttccccatct 3061 tcagcctgca ggttggaggg aactggggat gcatgagaag catgggttag ggtgagggac 3121 aggggagaag gtaggggctg gcttgggtgt gacatgggag cagggcctca gcatgctacc 3181 ctgcaggcat acccggaggc gggcacgatc gagggcctgg cctcgctgtt ggtggccctg 3241 ctggagaaga ccacgtgggt cgaccgtgtg cacatcctgc aggtgctact gagactgctg 3301 cccaacatga gcagtgatct ccaaggccag ctgcagggcc tgctcgtaca cttgctcaac 3361 ctggacc agc cccccagcct ccaggaccag acacagaaga agttcgtgat actggcgctg 3421 cagctgctcc tggcctgctc cctggagtcc cgggatgtgg tgctggagct catgtcctac 3481 ttcctctact ctcccgtgca ctgccggcca gagctcaaga agctgctgca cgggctgggc 3541 cttcaggacc cagagggctt cctattcaag gagatgatga cctgggtcca gggcccagac 3601 ctggactcca aggccggcct gcgcacttgc tgccaccaga aactggagga catgatccag 3661 gagcttcagg ttgggccggc aggggccggg ggggccttgg gaaccctgtt gccttctctg 3721 gctttctgca agtcctgggg tcaaagccag ctgaggccac aggctccttc cttgccttgc 3781 ccagtcctgg gcctccagcc tccctgccct gagcatctct agggatttcc ctgtgcagct 3841 ggaagtcagc agggggtgtc tggcccgaac cagggacagc cctgggacct ccttgtcagg 3901 ggagtggcag cccctgcctt gggctgagca tcgggcagaa gggagtttca gtggccatgt 3961 ggatgctcga ggagccaggg tgcttggcca tgggtcacct cctgacagat ggaaagctcg 4021 cagccactgt ctgcagccaa gttgctggtg gtgctgccca aggtctctaa gaccttagca 4081 ctttcctctc ctcccaagga gaccccatcg cagacgtcag tggtctctgg ggcacccaca 4141 cgcgcctccg tgataccctc gggcacctcc tggtcggcct ccggcatctt cgggaggctc 4201 tcgcaggtct ca gaggtgcc tttgatggtg gtctcacctg cggagccgca ctctttagcc 4261 ccggagctcc aggcccagcg gatgctggca cccacgcgca gctgggggac ccctcagctc 4321 cgtctcagag tgctctccga gacgctgaag agcttctgcc tggagcccga ggcccgcctg 4381 caccctgccg ggcctgctca gctgcccgga gagccgccgc cgctggagga gaccgactgg 4441 tcgcactcgc agctgctgga cttgggcccc atcgacgcgc tcaacttctt ctgtgagcag 4501 ctgcgggcgc agcagcggag ttcgctccag gagaaggctg cgcacccaca cccgccagtg 4561 ccctacacgg tggcgccggt gcccgacatg gtggtgccac ctccgcggga gcactggtac 4621 caccccatcc tccggctgca ggaggccaag ccgcagaggt ccgcgaggtc cgcgatgaga 4681 ctgaggggcc ccatgccgtc ccggctctgt gcgggccgca ccctggacgg ccccatccgg 4741 acgctgaagc tgccgttgcc gcgtgtggag ccgcagcctt tccccctgga ctggcctatg 4801 cccccgcgcc cgctgccccc gcggctcctg cagccggccc tgcagcgcta ctttctgcca 4861 gcggacgcgg accctgacac ctacagctga ccgggctggt ggcctcagcc cgcctggctc 4921 tggggcctgt cattggtatt tggccaaggc ctgcatcggg aataaagtcc agagaatttc 4981 <210> 179 <211> 5319 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1731) .. (4142) <400> 179 tgtaacgtgg agcctggtcg ccccagcccg ggagaggggg accctgcccg caccctcctg 60 gtctggggag ggcctagtgg cagcccaggt gcagtgggcc ggaggccagg ggagcccgtg 120 taggggaacc gcctggcctc tgttcagtgt gcccctcccc tgggtggggc ttcaggcgct 180 gagtcatggc tttggttggg gggcagcctc accctcctcc ccgtcctcca agctgctgag 240 gaaatcctgg gctgagcaca gcagaggagg cctaggtccc caggactgag gaagggagag 300 ctgaggggct cccagcagtg ggagcggctc tcggggcctc tgccagggcc caccctgtcc 360 ccatgagcac gtccgtgagc tcctgggtgc agccatcccc ccttgctggc tctccaggga 420 cacgggcgcc ccaaacccga gggcggcagc tctgggtgca gctgtctctg catccggccc 480 tgctcagggg tggctgcaac tcctggggtg tggcgctctc tgctgccttc tcctgggagg 540 atggtccctt ctctgttctg ggatcctcca gctgaggtag aggtcagggt ccaggggctg 600 caggctgggc actggcggtc agcggacacc acagcgagat tccctccatc gccccctgct 660 tcgggattca gagtcctctt agccccttgg gaacaagaga gggctgctca gagaggacct 720 agtgtccttc tggggtggct gggacccttc aaggtccctg gctggggcag cctggtgcct 780 gcagctccag ctcctaattg aggacacgcc ccatgtaaac cacaggcccc tcccccgagg 840 cctgggacac cggtcagggt agcaaggtac gagggactgt aggccctgat ggcctctgct 900 cctggacccc tgccctagac ctggagtcct ggccccagcc cgggccctgt ggtgcccaat 960 ccccaggagg ccagatggcc cggacagcca gtgagccgat tgtgtggagg gctgccggga 1020 tcctggccct gtttccctgt tgcctgctcc cggagggggt ggtcacgtgc ccgatccatc 1080 tgcctcctgt cttccgggga ttctcccgcc gaggcttctc tggtgatgtc atgccttaac 1140 tcttctctcc ccaggcagcc ccactgtcag gctgtcctgg tgggagtggg ctctgaggag 1200 gatggcctac ccgtctttcc agcggaccat gccgcttgca gctgtgaggt tgggggagcc 1260 gggggcgtct ctccccagct ggtctgggtc ctcctggtgc tgccaggacc gagagcagct 1320 gccctactgc ccccaccctg tcccacagtg catgggcgcc agacctggat gggctgcagt 1380 agtgcagtgg ggtgagggga ggtgccgcag ggttgagggg ctccagatgg gtccagggtt 1440 gactctgaac tcctagagga gaggcgggtg aggctggctc agcccttggt gggcactgtc 1500 cctgagggac tcccagcggc cggctgtcct gggagaggct ggtccagcct tcttccccga 1560 gggcacagca gcggctgcct ctgcctgcct ggggttgggg gggcgggggg aagtgcactg 1620 aacctggtcc cagtcctgcc cccgtagcag gcaggcgtct gtctcccagc ctgtttcctg 1680 aaagcccctt cccatgg tgg agcccctcag ggaggtgcgg ggggaggtga agc ccc 1736 Ser Pro 1 gag ggg gct gag gct gca ggt gac ccc agc cag ccc cgt tct tgc ttt 1784 Glu Gly Ala Glu Ala Ala Gly Asp Pro Ser Gln Pro Arg Ser Cys Pg 10 acc gac gag gtg gag acg gac gtg gtg gag att gag gcc 1832 Arg Ala Thr Ile Asp Glu Val Glu Thr Asp Val Val Glu Ile Glu Ala 20 25 30 aaa ctg gac aag ctg gtg aag ctg tgc agt ggc atg gtg gagcc Leu Asp Lys Leu Val Lys Leu Cys Ser Gly Met Val Glu Ala Gly 35 40 45 50 aag gcc tac gtc agc acc agc agg ctt ttc gtg agc ggc gtc cgc gac 1928 Lys Ala Tyr Val Ser Thr Ser Arg Leu Phe Val Ser Gly Val Arg Asp 55 60 65 ctg tcc cag cag tgc cag ggc gac acc gtc atc tcg gaa tgt ctg cag 1976 Leu Ser Gln Gln Cys Gln Gly Asp Thr Val Ile Ser Glu Cys Leu Gln 70 75 80 agg ttc gct gac agc cta cag gag gtg aac tac cac atg atc ctg 2024 Arg Phe Ala Asp Ser Leu Gln Glu Val Val Asn Tyr His Met Ile Leu 85 90 95 ttt gac cag gcc cag agg tcc gtg cgg cag cag ctc cag agc ttt gtc 2072 Phe Asp Gln Ala Gln Arg Ser Val Arg Gln Gln Leu Gln Ser Phe Val 100 105 110 aaa gag gat gtg cgg aag ttc aag gag aca aag aag cag ttt gac aag 2120 Lys Glu Asp Val Arg Lys Phe Lys Glu Thr Lys Lys Gln Phe Asp Lys 115 120 125 130 gtg cgg gag gac ctg gag ctg tcc ctg gtg agg aac gcc cag gcc ccg 2168 Val Arg Glu Asp Leu Glu Leu Ser Leu Val Arg Asn Ala Gln Ala Pro 135 140 145 agg cac cgg ccc cac gag gtg gag gag gacc g gcc ctc acc ctc 2216 Arg His Arg Pro His Glu Val Glu Glu Ala Thr Gly Ala Leu Thr Leu 150 155 160 acc agg aag tgc ttc cgc cac ctg gca ctg gac tat gtg ctc cag atc 2264 Thr Arg Lys Cys Phe Arg His Leu Ala Leu Asp Tyr Val Leu Gln Ile 165 170 175 aat gtt ctg cag gcc aag aag aag ttt gag atc ctg gac tct atg ctg 2312 Asn Val Leu Gln Ala Lys Lys Lys Phe Glu Ile Leu Asp Ser Met Leu 180 185 190 tcc ttc atgac gcc cag tcc agc ttc ttc cag cag ggc tac agc ctc 2360 Ser Phe Met His Ala Gln Ser Ser Phe Phe Gln Gln Gly Tyr Ser Leu 195 200 205 210 ctg cac cag ctg gac ccc tac atg aag aag ctg gca gcc gagg c 2408 Leu His Gln Leu Asp Pro Tyr Met Lys Lys Leu Ala Ala Glu Leu Asp 215 220 225 cag ctg gtg atc gac tct gcg gtg gaa aag cgt gag atg gag cga aag 2456 Gln Leu Val Ile Asp Ser Ala Val Glu Lys Arg Glu Met Glu Arg Lys 230 235 240 cac gcc gcc atc cag cag cgg acg ctg ctg cag gac ttc tcc tac gat 2504 His Ala Ala Ile Gln Gln Arg Thr Leu Leu Gln Asp Phe Ser Tyr Asp 245 250 255 gag tcc aaa gtg gag ttt gac gtg gac gcg ccc agt ggg gtg gtg atg 2552 Glu Ser Lys Val Glu Phe Asp Val Asp Ala Pro Ser Gly Val Val Met 260 265 270 gag ggc tac ctc ttc aag agg gcc agc aac gct ttc aag aca tgg aac 2600 Glu Gly Phe Lys Arg Ala Ser Asn Ala Phe Lys Thr Trp Asn 275 280 285 290 cgg cgc tgg ttc tcc att cag aac agc cag ctg gtc tac cag aag aag 2648 Arg Arg Trp Phe Ser Ile Gln Asn Ser Gln Leu Val Tyr Gln Lys 300 305 ctc aag gat gcc ctc acc gtg gtg gtg gat gac ctc cgc ctg tgc tct 2696 Leu Lys Asp Ala Leu Thr Val Val Val Asp Asp Leu Arg Leu Cys Ser 310 315 320 gtg aag ccg tgt gag gag atc gag cgg tc tgc ttc gag gtg ctg 2744 Val Lys Pro Cys Glu Asp Ile Glu Arg Arg Phe Cys Phe Glu Val Leu 325 330 335 tca ccc acc aag agc tgc atg ctg cag gct gac tcc gag aag ctg cgg 2792 Ser Pro Thr Lys Ser Cys Leu Gln Ala Asp Ser Glu Lys Leu Arg 340 345 350 caa gcc tgg gtc cag gct gtg cag gcc agc atc gcc tcc gcc tac cgc 2840 Gln Ala Trp Val Gln Ala Val Gln Ala Ser Ile Ala Ser Ala Tyr Arg 355 360 365 370 gag agc cct gac agt tgc tat agc gag agg ctg gac cgc aca gca tcc 2888 Glu Ser Pro Asp Ser Cys Tyr Ser Glu Arg Leu Asp Arg Thr Ala Ser 375 380 385 cc g tcc acg agc agc atc gac tcc gcc acc gac act cgg ggc 2936 Pro Ser Thr Ser Ser Ile Asp Ser Ala Thr Asp Thr Arg Glu Arg Gly 390 395 400 gtg aag ggc gag agt gtg ctg cag cgt gtg cag agt gtg gcc ggc aac 2984 Val Lys Gly Glu Ser Val Leu Gln Arg Val Gln Ser Val Ala Gly Asn 405 410 415 agc cag tgc ggc gac tgc ggc cag ccg gac ccc cgc tgg gcc agc atc 3032 Ser Gln Cys Gly Asp Cys Gly Gln Pro Asp Pro Arg Trp Ala Ser Ile 420 425 430 430 aac ctg ggc gt tc tgc att gag tgc tcc ggc atc cac agg agc 3080 Asn Leu Gly Val Leu Leu Cys Ile Glu Cys Ser Gly Ile His Arg Ser 435 440 445 450 ctg ggt gtc cac tgc tcc aag gtg cgg tcc ctg acg ctg gac 128 Gly Val His Cys Ser Lys Val Arg Ser Leu Thr Leu Asp Ser Trp 455 460 465 gag cct gag ctg cta aag ctg atg tgt gag ctt gga aac agc gct gtg 3176 Glu Pro Glu Leu Leu Lys Leu Met Cys Glu Leu Gly Asn Ser Ala Val 470 475 480 aat cag atc tat gag gcc cag tgt gag ggt gca ggc agc agg aaa ccc 3224 Asn Gln Ile Tyr Glu Ala Gln Cys Glu Gly Ala Gly Ser Arg Lys Pro 485 490 495 aca gcc agc agc tcc cgg gag gac gcc tgg atc aag gac aaa 3272 Thr Ala Ser Ser Ser Arg Gln Asp Lys Glu Ala Trp Ile Lys Asp Lys 500 505 510 tac gtg gaa aag aag ttt ctg cgg aag gcg ccc atg gca cca gcc ctg 3320 Tyr Val Glu Lys Phe Arg Lys Ala Pro Met Ala Pro Ala Leu 515 520 525 530 gag gcc cca aga cgc tgg agg gtg cag aag tgc ctg cgg ccc cac agc 3368 Glu Ala Pro Arg Arg Trp Arg Val Gln Lys Cys Leu Arg Pro His Ser 535 540 54 5 tct ccc cgc gct ccc act gcc cgc cgc aag gtc cgg ctt gag ccc gtt 3416 Ser Pro Arg Ala Pro Thr Ala Arg Arg Lys Val Arg Leu Glu Pro Val 550 555 560 ctg ccc tgt gtg gcc gct ctg tcc tca gtg ggc acc gat cgt aag 3464 Leu Pro Cys Val Ala Ala Leu Ser Ser Val Gly Thr Leu Asp Arg Lys 565 570 575 ttc cgc cga gac tcc ctc ttc tgt ccc gac gag ctg gac tcg ctc ttc 3512 Phe Arg Arg Asp Ser Leu Phe Cys Glu Leu Asp Ser Leu Phe 580 585 590 tcc tac ttc gac gca ggg gcc gca ggg gct ggc cct cgc aag ggt gca 3560 Ser Tyr Phe Asp Ala Gly Ala Ala Gly Ala Gly Pro Arg Lys Gly Ala 595 600 605 610 gag tcg ag tcc agc ggt gag gca gac ggg gac act gag gcc gag 3608 Glu Ser Glu Glu Ser Ser Gly Glu Ala Asp Gly Asp Thr Glu Ala Glu 615 620 625 gcc tgg ggc ctg gcg gac gtg cgc gag ctg cac ccg ggg ctc 656 Trp Gly Leu Ala Asp Val Arg Glu Leu His Pro Gly Leu Leu Ala 630 635 640 cac cgc gca gcg cgt gcc cgc gac ctt cct gcg ctg gcg gcg gcg ctg 3704 His Arg Ala Ala Arg Ala Arg Asp Leu Pro Ala Leu Ala Leu 645 650 655 gcc cac ggg gcc gag gtc aac tgg gcg gac gcg gag gat gag ggc aag 3752 Ala His Gly Ala Glu Val Asn Trp Ala Asp Ala Glu Asp Glu Gly Lys 660 665 670 670 acg ccg ctg gtg cag ggc tcc ttg atc gtc tgt gag 3800 Thr Pro Leu Val Gln Ala Val Leu Gly Gly Ser Leu Ile Val Cys Glu 675 680 685 690 ttc ctg ctg caa aac gga gcg gac gtg aac caa aga gac agc cgg ggc Leu Phe Leu Gly Ala Asp Val Asn Gln Arg Asp Ser Arg Gly 695 700 705 cgg gcg ccc ctg cac cac gcc acg ctg ctg ggc cgc acc ggc cag gtt 3896 Arg Ala Pro Leu His His Ala Thr Leu Leu Gly Arg Thr Gly Gln Val 710 715 720 tgc ctg ttc ctg aag cgg ggc gcg gac cag cac gcc ctg gac caa gag 3944 Cys Leu Phe Leu Lys Arg Gly Ala Asp Gln His Ala Leu Asp Gln Glu 725 730 735 735 cag cgg gac ccg ttg gcc atg gc gg gcc atg gac atc 3992 Gln Arg Asp Pro Leu Ala Ile Ala Val Gln Ala Ala Asn Ala Asp Ile 740 745 750 gtg aca ctg ctc cgt ctg gcg cgc atg gcg gag gaa atg cgc gag gcc 4040 Val Thr Leu Leu Arg Leu Ala Ala Glu Glu Met Arg Glu Ala 755 760 765 770 770 gag gct gcc cct ggt ccc ccg ggc gcc ctg gcg ggc agc ccc acg gag 4088 Glu Ala Ala Pro Gly Pro Pro Gly Ala Leu Ala Gly Ser Pro Thr Glu 775 780 785 ctc cgc agg tgt atc cag gag ttc atc agc ctc cac ctg gaa 4136 Leu Gln Phe Arg Arg Cys Ile Gln Glu Phe Ile Ser Leu His Leu Glu 790 795 800 gag agc tagggccggg caggccgggc agctgccacc ccgcccggcc cgacgccccg 4192 Glu Ser catgccccga agtccctggc gcccacccgg ccgcggccct gcgtgtgacc cgcgggtcga 4252 tacctggcag ccccagtgct ggggcgccgc ggccctgctc gcccaggagg agagcgaggg 4312 ccccacactg agtctcttga agcctcacgt ttccctgggg gggtgctgca tcgtcgggtg 4372 tccctcaccc cacctgggga acctctgtct tcaggtcacc ccttttcagg ggcctgggtt 4432 gctcatgtca caagccactt ttaaggcccg tgtcacctgt gtccctgtgt cctcagggcc 4492 tgtgttactt cgtgccccac ttctgcccag aacactgacc tgttagctgg ctccctcctg 4552 cacaccccag agcctcctcc cagggcagaa agggtggccc atccagggaa ccaacgagta 4612 cctcacttag tgaccccagc atccaggctg gcgtcgcggg tgctgggcgg gaggggctct 4672 ggcctgggtc ctcagccct g gctggacgcg ggcgtcccaa ggccacgtgg ctggccacga 4732 aggtccccgt gccagacagc cccagccgca tcccggcctc ctccggaggc accttctcct 4792 ggtactcggc ccagagcctg cgcataaagc cactttgcca ctttgcagcc ctcatctcat 4852 gttctttgta gcggaccgag tgggtttgct ataggcctcg tctgactttg tcttgcgtct 4912 tttctctgtg gactcttgag gacgcctgag ccccagccct gcccctgacc agcctccccc 4972 ttgggtccag gggtctttcg gctcatattg cagggcctgc caatgccttc acgcacccct 5032 tccccaaagg tgcccggcag ggaggcaggg cctcccccac tcagcgcagg tcaggctaag 5092 gccagtcggc tggtcactat gcaatgctgc cctggggagg ctccctgagg gcacagtggg 5152 cgctggaccc ggccccccaa ctctcttgcc tgctgcctgt gaccctgaag aacagaattg 5212 attcttgccc ctctccctgt gtgagcttgg ccccgcctct tgccccaggc ccctgctggc 5272 gggtctcacc ccccacccct cgctttgaat aaagcacttg cgcccac 5319 <210> 180 <211> 4587 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1101) <400> 180 gcc gcg ggg agg gct gtg ccg gtt gct ttc tgc agc cgc atc tcg gcc 48 Ala Ala Gly Arg Ala Val Pro Val Ala Phe Cys Ser Arg Ile Ser Ala 1 5 10 15 agc tct cct cgc cgt ccc cgg ggc gct gtg cgt ctc cag tcc ggg acc 96 Ser Ser Pro Arg Arg Pro Arg Gly Ala Val Arg Leu Gln Ser Gly Thr 20 25 30 gaa gcc gcc tgc cgt agc ggg cgg cca gat ccg cgt ccc gcc tca gcg 144 Glu Ala Ala Cys Arg Ser Gly Arg Pro Asp Pro Arg Pro Ala Ser Ala 35 40 45 gcc gga gga cat gcg gga gag aga atg agc cag agg gac acg ctg gtg 192 Ala Gly Gly His Ala Gly Glu Glu Arg Met Ser Gln Arg Asp Thr Leu Val 50 55 60 cat ctg ttt gcc gga gga tgt ggt ggt aca gtg gga gct att ctg aca 240 His Leu Phe Ala Gly Gly Cys Gly Gly Thr Val Gly Ala Ile Leu Thr 65 70 75 80 tgt cca ctg gaa gtt gta aaa aca cga ctg cag tca tct tct gtg acg 288 Cys Pro Leu Glu Val Val Lys Thr Arg Leu Gln Ser Ser Ser Val Thr 85 90 95 ctt tat att tct gaa gtt cag ctg aac acc atg gct gga gcc agt gtc 336 Leu Tyr Ile Ser Glu Val Gln Leu Asn Thr Met Ala Gly Ala Ser Val 100 105 11 0 aac cga gta gtg tct ccc gga cct ctt cat tgc cta aag gtg atc ttg 384 Asn Arg Val Val Ser Pro Gly Pro Leu His Cys Leu Lys Val Ile Leu 115 120 125 gaa aaa gaa ggg cct cgt tcc ttg ttt aga gga cta ggc ccc aat tta 432 Glu Lys Glu Gly Pro Arg Ser Leu Phe Arg Gly Leu Gly Pro Asn Leu 130 135 140 gtg ggg gta gcc cct tcc aga gca ata tac ttt gct gct tat tca aac 480 Val Gly Val Ala Pro Ser Arg Ala Ile Tyr Phe Ala Ala Tyr Ser Asn 145 150 155 160 tgc aag gaa aag ttg aat gat gta ttt gat cct gat tct act caa gta 528 Cys Lys Glu Lys Leu Asn Asp Val Phe Asp Pro Asp Ser Thr Gln Val 165 170 175 cat atg att atca gct gca atg gca ggt ttt act gca atc aca gca acc 576 His Met Ile Ser Ala Ala Met Ala Gly Phe Thr Ala Ile Thr Ala Thr 180 185 190 aac ccc att tgg ctt ata aag act cgg tta cag ctt gat gca agg aac 624 Asn Pro Ile Trp Leu Ile Lys Thr Arg Leu Gln Leu Asp Ala Arg Asn 195 200 205 cgc ggg gaa agg cga atg ggt gct ttt gaa tgt gtt cgt aaa gtg tat 672 Arg Gly Glu Arg Arg Met Gly Ala Phe Glu Cys Val Arg Lys T yr 210 215 220 cag aca gat gga cta aaa gga ttt tat agg ggc atg tct gct tca tat 720 Gln Thr Asp Gly Leu Lys Gly Phe Tyr Arg Gly Met Ser Ala Ser Tyr 225 230 235 240 gct ggt ata tca gag act gtt atc cat ttt gtt att tat gaa agt ata 768 Ala Gly Ile Ser Glu Thr Val Ile His Phe Val Ile Tyr Glu Ser Ile 245 250 255 aaa caa aaa cta ctg gaa tat aag act gct tct aca atg gaa aat gat 816 Lys Gln Lys Leu Leu Glu Tyr Lys Thr Ala Ser Thr Met Glu Asn Asp 260 265 270 gaa gag tct gtg aaa gaa gca tca gat ttt gtg gga atg atg cta gct 864 Glu Glu Ser Val Lys Glu Ala Ser Asp Phe Val Gly Met Met Leu Ala 275 280 285 gct gcc acc tca aaa act tgt gcc aca act ata gca tat cca cat gaa 912 Ala Ala Thr Ser Lys Thr Cys Ala Thr Thr Ile Ala Tyr Pro His Glu 290 295 300 gtt gta aga aca aga cta cgt gaa gag gga aca aaa tac aga tct ttt 960 Val Val Arg Thr Arg Leu Arg Glu Glu Gly Thr Lys Tyr Arg Ser Phe 305 310 315 320 ttt cag act cta tct ttg ctt gtt caa gaa gaa ggt tat ggg tct ctt 1008 Phe Gln Thr Leu Ser Leu Leu Val Gln Glu GluGly Tyr Gly Ser Leu 325 330 335 tat cgt ggt ctg aca act cat cta gtg aga cag att cca aac aca gcc 1056 Tyr Arg Gly Leu Thr Thr His Leu Val Arg Gln Ile Pro Asn Thr Ala 340 345 350 att atg atg gcc acc tat gaa ttg gtg gtt tac cta ctc aat gga 1101 Ile Met Met Ala Thr Tyr Glu Leu Val Val Tyr Leu Leu Asn Gly 355 360 365 tagcagcacg aggactgctg tactgcaaaa aaagaagacc aaaagattac agtggaccat 1161 gggatacaga agccagcatg gcagacagaa gaaaaatagt ttgggaacat gtaactattc 1221 taagtggaag ttttgttgta ggaattatag taatcacacc acattacttg gcctttcggt 1281 aatgtgaaaa aaaaaaaaaa acctcagagc ctccaaggaa atgcctttag aagcactcct 1341 ctctcaaaat tgccattttc tctaccatgt cccccagaca cagttgggtt ttgttgattt 1401 atggcagtct tctaaacaaa gccatcctta attttacata ctgtattgta actatccaaa 1461 gatagtattg gcagtcataa atttataact tctggccttt gtttaattcc agtaaaataa 1521 cagcaatgac aatgagatcg tcagtattat tttcacattt ccctgagagg acctggcaca 1581 atattttaaa tttaattatt tggcagtagt cactgttttt gacaaccaat gaaatagcgt 1641 ctaaatatct tgtatatttt ttagcatcaa aatgttttgg tt tccactgc tgacaggtgc 1701 ttgttgttta gcctaatgtg gatatttaaa ttgttaacat accaaacaca catggtaata 1761 gtttgggaca aaataactag taaaatgttg atttctcggc tatttcactg actgcggcat 1821 gtcctcgtgt cttctctgat tttgtggtac atgaatgaat gcatttatct ttttagtgac 1881 ttactagtta cgaacttgaa ttatcacctc tttgtcatac ttaagtatca tttacataaa 1941 gtgtaaaaga ttttttcact tttgaatctt tacctacttg ctttcacatt aagaatttga 2001 acttttgagt tttttccagg tctatatata atagattaca tttattttgt aaagaaaata 2061 gtaatttaaa gttttgccat tttaaggtga caatatttgg gacagtataa atattataga 2121 caagggcccc cttgctgtct gctttagcag gtagtgacat taattgactt atagttttgt 2181 gtaaatgaac aaactgcttt tgacaagaaa tttattctgt cctagtttcc tgcatggtaa 2241 atcatagaaa gattcaagtt catttgggtt aaatgtgcta ataggatgta gcttttaaat 2301 tctgctattg agtcagctgt accttttaat actttaaatg tgttatttgt atggccctta 2361 taaaggtgtt tgctgtaatt ctgttaaaag acttcgccta tgccatactg gtgtataaaa 2421 actgccgcaa ttggacgccg gtgtggtact catttcagta tacctgaact gtacattttg 2481 tgcaatggct ttatctaaaa gaatgacgct tcgtgaaagc actttgtg gc cttttttggg 2541 ggggagggtg agagagtagg agagaatacc atgttaagat taaaaaaaaa aacaaaaaca 2601 ttggtcatgt attaggcaga aacagtgttc ataacatttt tctgggtttt aaatatgttg 2661 tttcggatat ccttaatata aatgttttag gtattctgtg taccctgtcg tacccccaac 2721 attatagaat attgcagtgt gtcattgcaa gctttctctg ctgtcaccag tgaaacatag 2781 tgccctgtta aattccccca ctttaacttc cttgtgatca acagtaactg gatgtttttg 2841 aggtgctcaa ttggaataaa aatattccaa tctatttgga gaccaaaggc aaaatcagtt 2901 ttcttacctt tggaattatt cgtacctttt atggtaaatt tcagctttga catgtattat 2961 gaggaacgta ccaaaaaccg gtttgtaaca aatctgtaga gaaggtctga atctatcgtg 3021 tttgcctttt caggtgccat ttctactgcc taatacagtg ccatttgcct tgtgaagacc 3081 cataaacatt cattgtgttg aatgtaagat agagactctc cctagtctta ctgatctcag 3141 taccccacaa atgattaaga atgatatgaa aaccagcagc taaggaacat cttattattt 3201 agttgtagca tattcataac aagtgtcctt caaggataaa catatattct ctatttgtat 3261 ttagcaagta aaacttgtgt tgacctttag tgcattatat tcagctttta acagtattat 3321 gtatgtactg gaaagcaaag aaatcttaga gtcttggaca ttgtttattt gt gcaacaac 3381 tagaaaggag caatgaagtt tatttcagtt gtatttttcc ctaagcacaa tctgcaatag 3441 tttatgtatg acagagataa ttcaaaaagg aaaactatat ataaaagttg tatataaagt 3501 ttgtctctga aatatttctt tgaagttttt aaaaaattga ctcatgttta aaaacaaaaa 3561 cacatattca gagcattgga cttttttaac ttgttttcat ctgtttatca tgactttttt 3621 atttctggtg tagagtccac attatttagt ttgttgtact tttaaatttc aaagttcaaa 3681 tctgaagaat tagcgtttgt gatttcggga taccatgcag tggttttaat cccaggaaaa 3741 aaactatcaa caaaagttcg tttgattctc attatgtaac tttgtagaac catcctttct 3801 agatgggtcc accacagtga atttgtaact ttgaagtcag gatagaatat cattagatta 3861 tctgtgagat agcattacta tgttaggacc agcagagttt gggttggtaa aaataatgtt 3921 tgctctatta ctgggttaca gacatttcag catttttagg ttggttttaa atcactaaaa 3981 atatttattc ggatttgaag gatttaagtg ctaaaaatca atccatttct tgcccttcaa 4041 taattgtcca tgcctgcctt ttgttgttta catgctcttc tgcccagact gttagtaatc 4101 tagggacccc ctttggagct gataagtaca gttcagcctt ttctcctcaa atatataatg 4161 actttaacat tcctaagaat ataggtattt ctgaatgatt taaatttgag gaatttta at 4221 acataaaata caatgtacaa actttctgcc cactcagatc tcttctccat catgtactta 4281 gtatttccca ttaacctaca cactgatttt tatgctactc cttgtagaaa caaaattctg 4341 gtttgactca gtttttgtgt ttataaactt ttggaatgtg taccccgttt atgtgaagaa 4401 ttatgaccta tcagtcatag ctaaatagtg aacctcaaaa gtgttaactt ttgactattc 4461 atgtgaggtt tggtatcttg catttatgta catggctgta aattatgtgc atttactctg 4521 tatttatgtt atctagctga cttttacttg aattgttcaa attttaaaaa ttaaaatacg 4581 ctcatg 4587 <210> 181 <211> 4171 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1444) <400> 181 g atc atc gcc gtt gag gaa aca gac gtt cac ggg aaa cat caa ggc agt 49 Ile Ile Ala Val Glu Glu Thr Asp Val His Gly Lys His Gln Gly Ser 1 5 10 15 gga aaa tgg cag aaa atg gaa aag cct tac gct ttt aca gtt cac tgt 97 Gly Lys Trp Gln Lys Met Glu Lys Pro Tyr Ala Phe Thr Val His Cys 20 25 30 gta aag aga gca cga cgg cac cgc tgg aag tgg gcg cag gtg act ttc 145 Val Lys Arg Ala Arg Arg His Arg Trp Lys Trp Ala Gln Val Thr Phe 35 40 45 tgg tgt cca gag gag cag ctg tgt cac ttg tgg ctg cag acc ctg cgg 193 Trp Cys Pro Glu Glu Gln Leu Cys His Leu Trp Leu Gln Thr Leu Arg 50 55 60 gag atg ctg gag aag ctg acg tcc aga cca aag cat tta ctg gta ttt 241 Glu Met Leu Glu Lys Leu Thr Ser Arg Pro Lys His Leu Leu Val Phe 65 70 75 80 atc aac ccg ttt gga gga aaa gga caa ggc aag cgg ata tat gaa aga 289 Ile Asn Pro Phe Gly Gly Lys Gly Gln Gly Lys Arg Ile Tyr Glu Arg 85 90 95 aaa gtg gca cca ctg ttc acc tta gcc tcc atc acc act gac atc atc 337 Lys Val Ala Pro Leu Phe Thr Leu Ala Ser Ile Thr Thr Asp Ile Ile 100 105 110 gtt act gaa cat gct aat cag gcc aag gag act ctg tat gag att aac 385 Val Thr Glu His Ala Asn Gln Ala Lys Glu Thr Leu Tyr Glu Ile Asn 115 120 125 ata gac aaa tac gac ggc atc gtc tgt gtc ggc gga gat ggt atg ttc 433 Ile Asp Lys Tyr Asp Gly Ile Val Cys Val Gly Gly Asp Gly Met Phe 130 135 140 agc gag gtg ctg cac ggt ctg att ggg agg acg cag agg agc gcc ggg 481 Ser Glu Val Leu His Gly Leu Ile Gly Thr Gln Arg Ser Ala Gly 145 150 155 160 gtc gac cag aac cac ccc cgg gct gtg ctg gtc ccc agt agc ctc cgg 529 Val Asp Gln Asn His Pro Arg Ala Val Leu Val Pro Ser Ser Leu Arg 165 170 175 att gga atc att ccc gca ggg tca acg gac tgc gtg tgt tac tcc acc 577 Ile Gly Ile Ile Pro Ala Gly Ser Thr Asp Cys Val Cys Tyr Ser Thr 180 185 190 gtg ggc acc agc gac gca gaa acc tcg gcg ctg cat atc gtt gtt ggg 625 Val Gly Thr Ser Asp Ala Glu Thr Ser Ala Leu His Ile Val Val Gly 195 200 205 gac tcg ctg gcc atg gat gtg tcc tca gtc cac cac aac agc aca ctc 673 Asp Ser Leu Ala Met Asp Val Ser Ser Val His His Asn Ser Th r Leu 210 215 220 ctt cgc tac tcc gtg tcc ctg ctg ggc tac ggc ttc tac ggg gac atc 721 Leu Arg Tyr Ser Val Ser Leu Leu Gly Tyr Gly Phe Tyr Gly Asp Ile 225 230 235 240 atc aag gac agt gag aagaaa tgg ttg ggt ctt gcc aga tac gac 769 Ile Lys Asp Ser Glu Lys Lys Arg Trp Leu Gly Leu Ala Arg Tyr Asp 245 250 255 ttt tca ggt tta aag acc ttc ctc tcc cac cac tgc tat gaa ggg aca 817 Phe Ser Gly Thr Phe Leu Ser His His Cys Tyr Glu Gly Thr 260 265 270 gtg tcc ttc ctc cct gca caa cac acg gtg gga tct cca agg gat agg 865 Val Ser Phe Leu Pro Ala Gln His Thr Val Gly Ser Pro Arg Asp Arg 275 280 285 285 aag ccc tgc cgg gca gga tgc ttt gtt tgc agg caa agc aag cag cag 913 Lys Pro Cys Arg Ala Gly Cys Phe Val Cys Arg Gln Ser Lys Gln Gln 290 295 300 ctg gag gag gag cag aag aaa gca ctg gtt gcg gag 961 Leu Glu Glu Glu Gln Lys Lys Ala Leu Tyr Gly Leu Glu Ala Ala Glu 305 310 315 320 gac gtg gag gag tgg caa gtc gtc tgt ggg aag ttt ctg gcc atc aat 1009 Asp Val Glu Glu Trp Gln Val CysLys Phe Leu Ala Ile Asn 325 330 335 gcc aca aac atg tcc tgt gct tgt cgc cgg agc ccc agg ggc ctc tcc 1057 Ala Thr Asn Met Ser Cys Ala Cys Arg Arg Ser Pro Arg Gly Leu Ser 340 345 350 ccg gct gcc cac gga gac ggg tct tct gac ctc atc ctc atc cgg 1105 Pro Ala Ala His Leu Gly Asp Gly Ser Ser Asp Leu Ile Leu Ile Arg 355 360 365 aaa tgc tcc agg ttc aat ttt ctg aga ttt ctc atc agg cac acc aac 1153 Lys Ser Arg Phe Asn Phe Leu Arg Phe Leu Ile Arg His Thr Asn 370 375 380 cag cag gac cag ttt gac ttc act ttt gtt gaa gtt tat cgc gtc aag 1201 Gln Gln Asp Gln Phe Asp Phe Thr Phe Val Glu Val Tyr Arg Val Lys 385 390 395 400 aaa ttc cag ttt acg tcg aag cac atg gag gat gag gac agc gac ctc 1249 Lys Phe Gln Phe Thr Ser Lys His Met Glu Asp Glu Asp Ser Asp Leu 405 410 415 aag gag ggg ggg aag aag cgc ttt ggg att tgc agc agc cac ccc 1297 Lys Glu Gly Gly Lys Lys Arg Phe Gly His Ile Cys Ser Ser His Pro 420 425 430 tcc tgc tgc tgc acc gtc tcc aac agc tcc tgg aac tgc gac ggg gag 1345 Ser Cys Cys Cys Thr V al Ser Asn Ser Ser Trp Asn Cys Asp Gly Glu 435 440 445 gtc ctg cac agc cct gcc atc gag gtc aga gtc cac tgc cag ctg gtt 1393 Val Leu His Ser Pro Ala Ile Glu Val Arg Val His Cys Gln Leu Val 450 455 460 cga ctc ttt gca cga gga att gaa gag aat ccg aag cca gac tca cac 1441 Arg Leu Phe Ala Arg Gly Ile Glu Glu Asn Pro Lys Pro Asp Ser His 465 470 475 475 480 agc tgagaagccg gcgtcctgat attatt gat gtcattagatgat ctcgaactggatat gat gat atttattttt 1554 gatagttaaa tcttgatttt agaagaaaac ccttttgtca acaattttgt gtacatattt 1614 ggcattttca gttctgtacg catctgcggg ttgcagccca cgccgcttac tctcagcgga 1674 tgcagctgct cacttggggg cactggcctc ttaggtttta acgatgtcaa cagtgtagtt 1734 tagaaaatgg cccgttagtg gctctattgc aataatgtta gggacattat atgatttcca 1794 cgcaggtcac accatctggg cctgaggtag cagtgggtca ctttgatcca ctttgcagga 1854 cttattctgt aacggtttgt ggccaagttt tgggaagtgg ttgattctct ttgccttcat 1914 ttcaccttcc tcttcgttta cggttaggac atcgctgctt gatccttaca atactgtgca 1974 actgcaatgc aac gtggccc tgcttcaggt gatccgcggg aggggcctcc acgccagcgc 2034 cgggaaggct gctggggcct ccacacctgc ctcatcacgg cggcgaggct acgacaatcc 2094 ggctgggagc atgaccttgg cgtctgttct gggagcacag atgataagct ctggaagctg 2154 gcagtgtgta aagcactggc aagtttgtta ctgttaaaat gtcaaatacc aatgctttat 2214 atcgacgcga agtgcttaac acagccgggc ttgggggcag tcaggaggaa gctggccatc 2274 cgtggaggag gggccggtcc tggactcccg caggactcct ctgatgcagg gcctgaagtc 2334 tgtacacgtg gtccagattt gtccttgtct tttcttcaca ctgagttctc tatatttatt 2394 gaacatcttg tccttttaag ccagagtagt gtaaactgcg tctcggatgt ctgtcttttg 2454 cctcgaagcc acgatggatc gctggtttcc tctgcagcgc gagggctccg gcgaccagag 2514 gattcttccc ggaaggcatt cctgccgcgc tccccggggc acccctcaat tgtgtactac 2574 gtccttgttt agtgtgtatc cgtgcccacg tagatgatgt ctgtaacgta gttttgtttg 2634 aaatatgaga atatgcggct taaactttga tctgtaagga gcggggccgt ggccgtttgg 2694 agcacgctgt agacaccgtt cctcatgctg ccgggtgggt tttgcagaag ctcccttagt 2754 gatttcatgt ttaacaggca gcatccattt tcagaatttc ctggcattga tttatatttt 2814 gaagcataca ggaaacttc t cgtttcctcg tttagcccca cccagatcag gtgaaagggc 2874 agctttaatg gtggttttta tggaccacat tatcagagag cactgtgcaa gccaaatggt 2934 tcaataatga atgaaaattc tgggtgtaaa gagtaaatat gccctggctc tttctaccaa 2994 tgtttgctcc tggttggaaa gaaaccaaag atttaagacg ggctgctctt ccagactggc 3054 tgtgcctgcc tgtgcccagc aacctgtgca gccggcagtg tgcctggtgt cacgccagga 3114 ggctgtggct gctgtgggcc ctctggaatt gtgctcctca caaagtttcc ccaaaaggtt 3174 cttctaagcc tttattgtcc ctggtaaatg tttcccggct gggcgcggtg gctcacgcct 3234 gtaatcccag cactttggga ggccgaggcg ggtggatcac ctaaggtcag gagtttgaga 3294 tcagcctgcc caacatggtg aaacctcgtc tctactaaaa atacacaact tagccagtct 3354 tgttggcgca cgcctgtaat ctcagctact agggacgctg aggcaggaga atcgcttgaa 3414 cccaagaaag aggtggaggt tgcggtgagc caagattgcg ccactgcact ccagcctggg 3474 caaacagagg gagactccat cgcccccccc caacaaaaaa aaaagtttcc catacactgg 3534 cctgccccaa aacccactaa caattttagc aaaacagtcc aggccaaaga ggaagcattt 3594 catgttcaat aagaaaccca gccattccgc atggctggtt cctgagtggc tctggtgata 3654 ctctccagcc acctgctgac att gagaatc tcagacctcg ggactgctgt tgcggtaccg 3714 tgtgtctgac acctgccagc agccctttgc tatctgcgcg caggatgggg gtgactgccc 3774 agacattccc gctagatagg ctctgatttc cggggcagcc tttcagatgc ggcagacata 3834 caacacctgt actttagagt tttaagggaa aaaaaatcag aagtgctggt tagatagtaa 3894 aaacttagga taacttagaa aggctagttt tagcttcctt tgtggctccc tggtgcaaaa 3954 caattagcag ttatgcaatg gacctgattc tagtttattc taattaagaa gtgaggccga 4014 gtttgacttc gttcctgaat acaatcttga gtaactggga aagtctgagt gaaaggatgg 4074 cctcattctc tttctaatct tgctggtttc aagattagaa aatggcatta tttgatctga 4134 aatgtttgag aagacacgaa taaagttact tgggcag 4171 <210> 182 <211> 4311 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (205) .. (855) <400> 182 cgcggcgcgg gcgcgcaccc ggagctgtgg acggagagtg cctccctctg gcctcagttt 60 cctcatgttg tagtagcgga gcatggcccg gaccgggccc ccgagaccgc cccgtgcaac 120 ctcaccgcca gcctgggggc ctcagcgact gggacgggac caaggggctc ggggattctc 180 cctgcccccg gccctggtgc gtga ctg acc ctc ctg ttc cca gag ccc cca 231 Leu Thr Leu Leu Phe Pro Glu Pro Pro 1 5 gcg cag gcc ggg atg ttc gtc ctg gtg gaa atg gtg gac acc gtc cgg 279 Ala Gln Ala Gly Met Phe Val Leu Val Glu Met Val Asp Thr Val Arg 10 15 20 25 atc ccc cct tgg cag ttt gag agg aag ctc aac gac tct att gcc gag 327 Ile Pro Pro Trp Gln Phe Glu Arg Lys Leu Asn Asp Ser Ile Ala Glu 30 35 40 gag ctg aac aag aag ttg gcc aac aag gtc gtg tac aac gtg gga ctc 375 Glu Leu Asn Lys Lys Leu Ala Asn Vals Tyr Asn Val Gly Leu 45 50 55 tgc att tgt ctg ttt gat atc acc aaa ctg gag gat gcc tat gta ttc 423 Cys Ile Cys Leu Phe Asp Ile Thr Lys Leu Glu Asp Ala Tyr Val Phe 60 65 70 cct ggg gat ggc gca tca cac acc aaa gtc cat ttt cgc tgc gtg gtg 471 Pro Gly Asp Gly Ala Ser His Thr Lys Val His Phe Arg Cys Val Val 75 80 85 ttt cat cca ttc cta gat gag att ctc att ggg aag atc aaa ggc tgc 519 Phe His Pro Phe Leu Asp Glu Ile Leu Ile Gly Lys Ile Lys Gly Cys 90 95 100 105 agc cca gaa gga gtg cac gtc tct cta ggc ttc ttc gat gac att ctc 567 Ser Pro Glu Gly Val His Val Ser Leu Gly Phe Phe Asp Asp Ile Leu 110 115 120 atc ccc cca gag tca ctg cag cag cca gcc aag ttc gac gaa gcgag Pro Pro Glu Ser Leu Gln Gln Pro Ala Lys Phe Asp Glu Ala Glu 125 130 135 cag gtg tgg gtg tgg gag tac gag acg gag gaa gga gca cac gac ctc 663 Gln Val Trp Val Trp Glu Tyr Glu Thr Glu Glu Gly Ala His Asp Leu 140 145 150 tac atg gac acc ggc gag gag atc cgc ttc cgg gtg gtg gac gag agc 711 Tyr Met Asp Thr Gly Glu Glu Glu Ile Arg Phe Arg Val Val Asp Glu Ser 155 160 165 ttt gtt gac acg tcc ccc aca ggg ccc tca gca gat gcc acc act 759 Phe Val Asp Thr Ser Pro Thr Gly Pro Ser Ser Ala Asp Ala Thr Thr 170 175 180 185 tcc agt gag gag ctg cca aag aag gag gct ccg tac acg ctt gtg gga 807 Ser Ser Glu Glu Leu Pro Lys Lys Glu Ala Pro Tyr Thr Leu Val Gly 190 195 200 tcc atc agt gag cca ggc ctg ggc ctt ctc tcc tgg tgg acc agc aac 855 Ser Ile Ser Glu Pro Gly Leu Gly Leu Leu Ser Trp Trp Thr Ser Asn 205 210 215 tagccctggg gctggacagt ggaccctacc agcctgcggg aaggtggtat ggccggctgt 915 gaagacaaca gcagctgagg ccgatgctaa ggagatagtg tctcgagctg gacagtgagg 975 caaggccagg agtgcccacc agcttgcccc gctcctccac catctaggcc ctgctcctcc 1035 ttcactgcag tgatggatcc atctgtggct gtggctgttg ggcctccact gaccttgact 1095 gaaaagaccc ttcctggacc ctggacttga caacaaacgg cacagacacc aatcactcac 1155 agaacagtca ctggttttgg attcttgttt tccttgcaag aacaaaaggt tctctagaat 1215 ccttcagcca ccaatgaaat gatcaggcag gagaaaaact ttagatggga gtcttgtcat 1275 caaaaataaa tacagttgca tggagctgct taagatctga accaaactca aaataggaag 1335 acgggggcta aaaagttatt ttaagaaccc ccccaccaca accacagtca ctccgtgggc 1395 taagcgggga gcaggaagca tgtctggtca caccatcttg gaataggaag ccatgggc gcgcgcgcggcggcggcggcggcggcgcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcgagcagag cctt cattctgttg agggcactgc cagcgcggaa 1575 ccactcaatc tgcgtctcgt tgaaggtgtg gttcaggagg atggtctcct gggtcccgtt 1635 ggggtgcttg atgatgcact tcaggggctg caaggagaag gtgggtgtgg gtggaagtgg 1695 tgggtactgt gtgcccttgg ccccgcaggg gggtcaggga gacagggcac tgcctgggga 1755 cctaagaggt cagcaggcaa accaaatcct aggccagtct gtgcctgatg gcccaggtca 1815 gacccaggtg gcacctacag gggattcctg gggcccagag ggtcctgcag tgggtgggct 1875 gtcccctgag tgccaggtcc tggtgagtaa agggaggttg gggaggtgtg agggccccgg 1935 gttgactcca acccccaact ctgagaagcc actttgcttt ctctgtgggg ccacctggag 1995 aactgggggc ctttccagct ggaatgaagc ctcctgggag aagctaccct ggggccagtg 2055 caggagggga aacaaggtgg ctgcccctca ccccaccacc tcagggggac ccgggcccct 2115 aaccttgcca ggggtgaagt ccttcaggcc ctgaatggtc agcttgtcca cagggtgaat 2175 cttgttgtag tcagccgggt cagcgaaggt cagaggcagc aggccctgtt tcttcaggtt 2235 ggtctctgga aagcaggcgg cattcggtca tcgggggcct gactagcctg gagagcttca 2295 ttttctgaac ccatctgggg ctctgggaga tgcccctaat cctgctgcct gggacaatgc 2355 ccgggcagtg actatggggc cctggtctgc tccctttcac taggggtgcc cctagcaagt 2415 gtgcgctggt gctgaggtct gcgaggcctt cctgctgcac attcatgatc agaaagaacc 2475 ccctggcaca tgtcctagat ctcagtggct cagatctaca agcctggaag cagggcctgc 2535 gggaagccgg gaagctgagc gtcggatgtg cactgtgtga gcctaagaag gggcaagagg 2595 ctgacgggcc tgtgggctgc agtggacaca gcctagaacc aggcccaact cagccacggg 2655 cagggagagt gaccttgatc actagggatg ggatgaggat ggcctgggta cagactccag 2715 ctcaccgtgg atcctggcaa agctcttggt gatgatggcc cggcccccaa ggtggcgagg 2775 ctccagagct gcatgctccc ggctcgagcc ctcgccgtag ttctcgtctc cgatcaccac 2835 ccacctgatg ccatgtttct gtcaggcaag cgggggtaag gttataaggc agaggagggc 2895 accgtcctca cctgtctggc cctacctgcc tggcctcacc cacctggcgc ctgggcatcc 2955 tgaggctccc ggtaaagggg ctggaggggc ccttcctcgc ctgctgccta agggcaagtg 3015 aagcctgcgt gaatgagacc caaacgaggc cccgagggga cagaggcacg tggttgtttg 3075 cagtggcaaa gaagacagaa gccacccatt ggtgcttggc agaggcaggt gtgtgtggag 3135 ggaggttggg tgagacaggg acggcctccg ggccccacac aagatgcatc tgtgaagctc 3195 aaggcgcccc cttcctggga gcaccctctg ccccac ccag ccaccagggg gtgccagagt 3255 cctttcaccc ggctgggcca ggacttgggt tcagccctgg ttctgtttgt ttctcaaagc 3315 agaaaaagtc caatcacctc agaccctctc tgcctgctca ctgtgaggcc ccgtgtagcc 3375 ccctctctga gcttttggcc tctgacttcc tgagtcggcc cccttccttg tctttgtcta 3435 gggccagata tcctaagata tctctcacta actcctcctg gtgcagggac ccggctgtac 3495 caccggacct gggcctcatg ccttctcagc cacagggagg ggctgcaggc ctctcctccc 3555 ttccacagca gtcccctttg ggcttggtcg gcctccttcc cagtttccac tcccctaatg 3615 tcctccctgc acctgccttg caggcccctt caggagtgac cactggcatt gcccctatca 3675 actctgaccc accttgtagt agcgggcagt gtcagggacg gggccaaact cctgagtgac 3735 ggcattgcgc acggagttgg ccttgccgtt ttcaatgttg atggcaccaa tgagcaggtt 3795 gttggagatg ttatccaagt gcccacggaa cttgagccag gggccagcag ctgagatgtg 3855 gtcagtggta cacttccctt tgaccttggg tggtaagtag agaggacaga ggtcagggca 3915 tggccctgga ggggtggatg acaagccctc cagaggcagc aggccccggg gcccaggagg 3975 ggtgacagag gggtgagagg caggcaagtc ttcagacacg tgttctgtgg tcctggtgct 4035 tccaccctaa ggccacatgg gctcaggcca ggccttcatc ccctcaaagg cctctggctg 4095 ctcagtctcc cttatggggc agaggccgcc caaagttggg acaggtcaat gttcgctcac 4155 ccttcaggcc tcagctgcaa gatcagccac agacctcatg ctggacacag gagcccagga 4215 catgcctggg tcctggctga tgactgatta gtctcttctg tcacaggggt gcctggagac 4275 cccttaataa gcagcataaa taaatatctg acacag 4311 <210> 183 <211> 4333 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3158) <400> 183 cc aaa gag gac cag atc aag aaa ctg cat gat ttg ctg ggg cca cac 47 Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu Gly Pro His 1 5 10 15 atg ctg cgg aga ctc aag gca gat gtc ttt aag aac atg cca gcc aag 95 Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro Ala Lys 20 25 30 aca gag ctc atc gtt cgg gtg gag cta agc ccc atg cag aag aaa tac 143 Thr Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln Lys Lys Tyr 35 40 45 tac aaa tac atc ctg act cga aat ttt gag gcc ttg aat tca cga ggt 191 Tyr Lys Tyr Ile Leu Thr Arg Asn Phe Glu Ala Leu Asn Ser Arg Gly 50 55 60 ggt ggg aac cag gtg tcg ctg ctt aat atc atg atg gat ctt aag aag 239 Gly Gly Asn Gln Val Ser Leu Leu Asn Ile Met Met Asp Leu Lys Lys 65 70 75 tgc tgc aac cat cca tac ctt ttt ccc gtg gct gct ccc gag tcc 287 Cys Cys Asn His Pro Tyr Leu Phe Pro Val Ala Ala Met Glu Ser Pro 80 85 90 95 aaa ctc ccc agt ggg gct tat gag ggt ggg gca ctt att aag tcg tct 335 Lys Leu Pro Ser Gly Ala Tyr Glu Gly Gly Ala Leu Ile Lys Ser Ser 100 105 110 gg g aag ctc atg ctg ctc cag aag atg ctg cga aag ctg aag gag caa 383 Gly Lys Leu Met Leu Leu Gln Lys Met Leu Arg Lys Leu Lys Glu Gln 115 120 125 gga cac cga gtg ctc atc ttc tcg cag atg acc gac ttg 431 Gly His Arg Val Leu Ile Phe Ser Gln Met Thr Lys Met Leu Asp Leu 130 135 140 ctt gag gac ttc tta gac tat gaa ggc tac aag tat gag cgc atc gat 479 Leu Glu Asp Phe Leu Asp Tyr Glu Gly Tyr Lys Tyr Glu Arg Ile Asp 145 150 155 ggt ggt atc acg ggt gcc ctg agg cag gag gcc atc gat cgg ttt aat 527 Gly Gly Ily Thr Gly Ala Leu Arg Gln Glu Ala Ile Asp Arg Phe Asn 160 165 170 175 gct cct ggg gcc caa caa ttc tgc ttc ctc ctg tcc acc cga gct ggg 575 Ala Pro Gly Ala Gln Gln Phe Cys Phe Leu Leu Ser Thr Arg Ala Gly 180 185 190 ggc ctg ggc atc aat ctg gcc act gct gac act gtc atc atc ttt gat 623 Gly Ile Asn Leu Ala Thr Ala Asp Thr Val Ile Ile Phe Asp 195 200 205 tct gac tgg aac ccc cat aat gac atc cag gcc ttt agc cgg gct cat 671 Ser Asp Trp Asn Pro His Asn Asp Ile Gln Ala Phe Ser Arg Ala His twenty one 0 215 220 cgg att ggc cag gcc aac aaa gtg atg att tac cgg ttt gtg act cgc 719 Arg Ile Gly Gln Ala Asn Lys Val Met Ile Tyr Arg Phe Val Thr Arg 225 230 235 gcg tca gtg gaa gag cga atc aca caagt aag aga aag atg atg 767 Ala Ser Val Glu Glu Arg Ile Thr Gln Val Ala Lys Arg Lys Met Met 240 245 250 255 ctg aca cac ctg gtt gtg cgg cct ggg ctg ggc tcc aag gca ggc tcc 815 Leu Thr His Leu Val Valg Pro Gly Leu Gly Ser Lys Ala Gly Ser 260 265 270 270 atg tcc aag cag gag ctt gac gac att ctc aaa ttt ggc act gaa gag 863 Met Ser Lys Gln Glu Leu Asp Asp Ile Leu Lys Phe Gly Thr Glu Glu Glu 275 280 285 cta ttc aag gat gaa aac gag ggg gag aac aag gag gag gac agc agt 911 Leu Phe Lys Asp Glu Asn Glu Gly Glu Asn Lys Glu Glu Asp Ser Ser 290 295 300 gtg att cat tat gac aat gag gcc atc gct cgg ctg ttg gac 959 Val Ile His Tyr Asp Asn Glu Ala Ile Ala Arg Leu Leu Asp Arg Asn 305 310 315 cag gat gca act gag gac act gac gtg cag aac atg aat gag tat ctc 1007 Gln Asp Ala Thr Glu Asp Thr Asp Val Gln Asn Met Asn Glu Tyr Leu 320 325 330 335 agc tcc ttc aag gtg gca cag tac gtc gtg cgg gaa gaa gac aag att 1055 Ser Ser Phe Lys Val Ala Gln Tyr Val Val Arg Glu Glu Asp Lys Ile 340 345 350 350 gag gaa att gag cgag atc aag cag gag gag aat gtg gac cct 1103 Glu Glu Ile Glu Arg Glu Ile Ile Lys Gln Glu Glu Asn Val Asp Pro 355 360 365 gac tac tgg gag aag ctg ctg agg cat cac tat gag caa cag cag gaa 1151 Asp Tyr Trp Lys Leu Leu Arg His His Tyr Glu Gln Gln Gln Glu 370 375 380 gac cta gcc cgg aat cta ggc aag ggc aag cgg gtt cgc aag caa gtt 1199 Asp Leu Ala Arg Asn Leu Gly Lys Gly Lys Arg Val Arg Lys Gln Val 385 395 aac tac aat gat gct gct cag gaa gac caa gac aac cag tca gag tac 1247 Asn Tyr Asn Asp Ala Ala Gln Glu Asp Gln Asp Asn Gln Ser Glu Tyr 400 405 410 415 tcg gtg ggt tca gag gag gat gat gaga gac gaa cgt cct gaa 1295 Ser Val Gly Ser Glu Glu Glu Asp Glu Asp Phe Asp Glu Arg Pro Glu 420 425 430 ggg cgt aga cag tca aag agg cag ctc cgg aat gag aaa gat aag cca 1343 Gly Arg Arg Gln Ser Lys Arg Gln Leu Arg Asn Glu Lys Asp Lys Pro 435 440 445 ctg cct cca ctg ctg gcc cga gtc ggg ggc aac att gag gtg ctg ggc 1391 Leu Pro Pro Leu Leu Ala Arg Val Gly Gly Asn Ile Glu Val Leu Gly450 455ac acc cgt cag cgg aag gct ttc ctc aat gct gtg atg cgc tgg 1439 Phe Asn Thr Arg Gln Arg Lys Ala Phe Leu Asn Ala Val Met Arg Trp 465 470 470 475 ggg atg cca cca cag gat gcc ttc acc aca cag tgg cg gtg gtg 1487 Gly Met Pro Pro Gln Asp Ala Phe Thr Thr Gln Trp Leu Val Arg Asp 480 485 490 495 ctg agg ggc aag act gag aag gag ttt aag gcc tat gtg tct ttg ttc 1535 Leu Arg Gly Lys Thr Glu Lys Glu Phe Lys Ayr Val Ser Leu Phe 500 505 510 atg cgc cat ctg tgt gag cct ggg gca gac ggc tct gaa acc ttt gcc 1583 Met Arg His Leu Cys Glu Pro Gly Ala Asp Gly Ser Glu Thr Phe Ala 515 520 525 gat ggg gtc cct cgg gag gga ctg agt cgc cag cag gtg ttg acc cgc 1631 Asp Gly Val Pro Arg Glu Gly Leu Ser Arg Gln Gln Val Leu Thr Arg 530 535 540 att gga gtc atg tct ctc gtc aaa aag aag gtg cag gag ttt gag cac 1679 Val Met Ser Leu Val Lys Lys Lys Val Gln Glu Phe Glu His 545 550 555 atc aat ggg cgt tgg tca atg ccg gaa ctg atg cct gac ccc agc gcc 1727 Ile Asn Gly Arg Trp Ser Met Pro Glu Leu Met Pro Asp Pro Ser Ala 560 565 570 575 gat tct aag cgc tcc tcc aga gcc tcc tct cct acc aaa acg tct ccc 1775 Asp Ser Lys Arg Ser Ser Arg Ala Ser Ser Pro Thr Lys Thr Ser Ser 580 585 590 590 acc act cct gag gct tct gct acc aac agt ccc tgc acc tct aaa cct 1823 Thr Thr Pro Glu Ala Ser Ala Thr Asn Ser Pro Cys Thr Ser Lys Pro 595 600 605 gct act cca gct cca agt gag aaa gga gaa ggc ata agg aca cct ctt 1871 Ala Thr Pro Ala Pro Ser Glu Lys Gly Glu Gly Ile Arg Thr Pro Leu 610 615 620 gag aag gag gaa gct gaa aac cag gag gaa aag cca gag aag aac agc 1919 Glu Lys Glu Glu Ala Glu Asn Gln Glu Glu Lys Pro Glu Lys Asn Ser 625 630 635 ggg gag aag atg gag aca gag gct gat gcc ccc agc cca gcc 1967 Arg Ile Gly Glu Lys Met Glu Thr Glu Ala Asp Ala Pro Ser Pro Ala 640 645 650 650 655 cca tca ctt ggg gag cgg ctg gag cca agg aag att cct ct a gag gat 2015 Pro Ser Leu Gly Glu Arg Leu Glu Pro Arg Lys Ile Pro Leu Glu Asp 660 665 670 gag gtg cca ggg gtg cct gga gag atg gag cct gaa cct ggg tac cgt 2063 Glu Val Pro Gly Val Pro Gly Glu Met Glu Pro Glu Pro Gly Tyr Arg 675 680 685 ggg gac aga gag aag tca gcc aca gag tcg acg cca gga gaa agg ggg 2111 Gly Asp Arg Glu Lys Ser Ala Thr Glu Ser Thr Pro Gly Glu Arg Gly 690 695 700 gag gag aag ccg ttg gat gga cag gaa cac agg gag agg ccg gag ggg 2159 Glu Glu Lys Pro Leu Asp Gly Gln Glu His Arg Glu Arg Pro Glu Gly 705 710 715 gaa aca ggg gat ttg ggc aag aga gaa gat gta aaa ggt gac cgg gag 2 Gly Asp Leu Gly Lys Arg Glu Asp Val Lys Gly Asp Arg Glu 720 725 730 735 ctt cga cca ggg cct cga gat gag cca cgg tcc aat ggg cga cga gag 2255 Leu Arg Pro Gly Pro Arg Asp Glu Pro Arg Ser Asn Gly Arg Arg Glu 740 745 750 gaa aag aca gag aag ccc cgg ttc atg ttc aat atc gcc gat ggt ggc 2303 Glu Lys Thr Glu Lys Pro Arg Phe Met Phe Asn Ile Ala Asp Gly Gly 755 760 765 ttc aca gag ctt tac acag ag aat gag gaa cgg gca gct att 2351 Phe Thr Glu Leu His Thr Leu Trp Gln Asn Glu Glu Arg Ala Ala Ile 770 775 780 tcc tcg ggg aaa ctc aat gag atc tgg cac aga aga cat gac tat tgg 2399 Ser Ser Gly Lys Le Asn Glu Ile Trp His Arg Arg His Asp Tyr Trp 785 790 795 ctt ctg gct ggg att gtc ctc cat ggc tat gca cgg tgg cag gac atc 2447 Leu Leu Ala Gly Ile Val Leu His Gly Tyr Ala Arg Trp Gln Asp Ile 800 805 815 cag aat gat gct caa ttt gcc att atc aac gag cca ttt aaa act gaa 2495 Gln Asn Asp Ala Gln Phe Ala Ile Ile Asn Glu Pro Phe Lys Thr Glu 820 825 830 gcc aat aag ggg aac ttt ctg gag atg aaa aat aag ctg gcc cgg 2543 Ala Asn Lys Gly Asn Phe Leu Glu Met Lys Asn Lys Phe Leu Ala Arg 835 840 845 agg ttc aag ctc ctg gag cag gcg ctg gtg att gag gag cag ctg cgg 2591 Arg Phe Lys Leu Leu Alu Ile Glu Glu Gln Leu Arg 850 855 860 cgg gcg gcc tac ctg aac ctg tcg cag gag ccg gcg cac ccc gcc atg 2639 Arg Ala Ala Ala Tyr Leu Asn Leu Ser Gln Glu Pro Ala His Pro Ala Met 865 870 c875 gcc ccc c cgc ttc gcc gag gcc gag tgc ctg gcc gag agc cac 2687 Ala Leu His Ala Arg Phe Ala Glu Ala Glu Cys Leu Ala Glu Ser His 880 885 890 890 895 cag cac ctc tcc aag gag tcg ctg gc gcc ag ag ag ag ag ag ag ag 2735 Gln His Leu Ser Lys Glu Ser Leu Ala Gly Asn Lys Pro Ala Asn Ala 900 905 910 gtc ctg cac aag gtt ctg aac cag ctg gag gag ttg ctg agc gac atg 2783 Val Leu His Lys Val Leu Asn Gln Leu Glu Glu Leu Ser Asp Met 915 920 925 aag gcg gac gtg acc cgc ctg cca gcc acg ctg tcc cga ata ccc ccc 2831 Lys Ala Asp Val Thr Arg Leu Pro Ala Thr Leu Ser Arg Ile Pro Pro 930 935 940 atc gca gcc cgc ctt cag atcc gag cgc agc atc ctc agc cgg ctg 2879 Ile Ala Ala Arg Leu Gln Met Ser Glu Arg Ser Ile Leu Ser Arg Leu 945 950 955 gcc agc aag ggc acg gag cct cac ccc aca ccg gcc tac ccg ccg Lyc Ggg A2 Glu Pro His Pro Thr Pro Ala Tyr Pro Pro Gly 960 965 965 970 975 ccc tac gct aca cct ccg ggg tac ggg gcg gcc ttc agc gcc gca ccc 2975 Pro Tyr Ala Thr Pro Pro Gly Tyr Gly Ala Ala Phe Ser Ala Ala Pro 980 985 990 gta ggg gcc ctg gcc gcc gca ggc gcc aat tac agc cag atg cct gca 3023 Val Gly Ala Leu Ala Ala Ala Gly Ala Asn Tyr Ser Gln Met Pro Ala 995 1000 1005 ggg tcc ttc atc aca gcc gcc acc ac ggc cct gtg ctt gtg aag 3071 Gly Ser Phe Ile Thr Ala Ala Thr Asn Gly Pro Pro Val Leu Val Lys 1010 1015 1020 aag gag aag gaa atg gtg ggg gca ttg gtg tca gac ggg ctg gat cgg 3119 Lys Glu Lys Glu Met Val Gly Ala Val Ser Asp Gly Leu Asp Arg 1025 1030 1035 aag gag ccc cga gcc ggg gag gtg atc tgt ata gac gac tgactggatc 3168 Lys Glu Pro Arg Ala Gly Glu Val Ile Cys Ile Asp Asp 1040 1045 1050 ccaggcctgc ccttccgcc ccttccgcc ccttccgcc ccttccgcc cttccccacc ccttgggcca tcactgggct aggaacccct 3288 ttgcccctct ctgcagctcc tctcttcaag aagggccctt tgtctttctc cactcccaca 3348 cacctttccc accaagcctt gaagactgtg ctggtgagaa gaagtctggg tgggagatgg 3408 ctggcagggt cttccaagta ccttcctccc acactgccaa gtatacacaa cttcccagta 3468 aatggttgtg gggaggaaag aggtggagcc tccccagccg tttccctgca ga atcagctc 3528 tgtctcatgt ggaagtggag aatcagcctt gcctggcctt taggaacttt tgtggggaag 3588 agagctttga agagaggagg gggactttag agagggatga aaatgagccc tgggagggag 3648 gaagggacga ggaggggtgg ctgcatgtta ccgtccccta cctctcccca cgtggagggt 3708 ggagcagtta tgagggagga agtcaactgc tgttcagcct cagaataaag gtgccgttca 3768 ctggctcagt tacctcctgt gtaccggcat cttgtgttgg gaatgttccc ccctccctag 3828 ggaccaagga ccacccctac aaaaagagta atggttgggt gatactccct caagccaaag 3888 aggagctccc caacctgttc tagggaccca ggtaacctag aagggtggga gagaatacaa 3948 tgggccagat gtggtggaag cccagctctg gggctcaggt tcctggaaga cttctactac 4008 cctccctcct caaggcctgg atacagacta aatttgtata agtcaggcag gggacctagt 4068 cagggtcttg ggagctacct tgtcgttggg accagagcaa aatagtggag ggcaggctag 4128 ggaaatgtgg gcacatcccc cctcccagga ggggccgggg agagtggcag tttgcatggc 4188 gaacccccca cttcctcttt gctgcccctt cactttcttg ctgccccttt cccagtctct 4248 cttcacaccc actcctggtc tgtcctgatc ccctcttctg tatcaggttt attggttgta 4308 catataaatt atactttcct ttctg 4333 <210> 184 <211> 4167 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3862) <400> 184 c aac aac aac aac tct agc caa ttc acc tgt ggt gtg ctc tgc cgc tgg 49 Asn Asn Asn Asn Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp 1 5 10 15 agt gag gag tgt ggc cgc gct gcc ggc agg gcc tgc ggc ttt gct cag 97 Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln 20 25 30 cca ggc tgc agc tgc cct gga gag gcg ggg gcc ggc tcc acc acc acc 145 Pro Gly Cys Ser Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr 35 40 45 aca tct cca ggc cct cct gct gcc cac acc ctg tcc aat gcc ctg gtg 193 Thr Ser Pro Gly Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val 50 55 60 ccc ggg ggc cca gcc cca cct gct gag gcc gat ttg cac tcg ggg agc 241 Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser 65 70 75 80 agc aat gat ctg ttc aca acc gag atg aga tat ggt gag gag ccg gaa 289 Ser Asn Asp Leu Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu 85 90 95 gag gaa ccg aaa gtg aaa acc cag tgg ccg agg tct gca gat gag cct 337 Glu Glu Pro Lys Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro 100 105 110 ggg cta tac atg gcg cag aca gtg gaa ggc cag tgg tta gaa tgg ggt 385 Gly Leu Tyr Met Ala Gln Thr Val Glu Gly Gln Trp Leu Glu Trp Gly 115 120 125 ccc tgg ggc cca tgc tcc acg tcc tgt gcc ag caa cag cgc 433 Pro Trp Gly Pro Cys Ser Thr Ser Cys Ala Asn Gly Thr Gln Gln Arg 130 135 140 agc cgg aag tgc agc gtg gcg ggc cca gcc tgg gcc aca tgc acg ggt 481 Ser Arg Lys Cys Ser Val Ala Gly Pro Ala Trp Ala Thr Cys Thr Gly 145 150 155 160 gcc ctc act gac acc cgg gag tgc agc aac ctc gag tgc ccg gcc act 529 Ala Leu Thr Asp Thr Arg Glu Cys Ser Asn Leu Glu Cys Pro Ala Thr 165 170 175 gat agc aag tgg ggg cca tgg aat gcg tgg agc ctg tgc tct aag acg 577 Asp Ser Lys Trp Gly Pro Trp Asn Ala Trp Ser Leu Cys Ser Lys Thr 180 185 190 tgt gac aca ggc tgg cag cgc cgc ttc cgc atg tgc cag gcc acg Asp Thr Gly Trp Gln Arg Arg Phe Arg Met Cys Gln Ala Thr Gly 195 200 205 acg cag ggc tac ccc tgc gag ggc acc gga gag gag gtg aag cct tgt 673 Thr Gln Gly Tyr Pro Cys Glu Gly Thr Gly Glu Glu Val Lys P ro Cys 210 215 220 agt gag aag agg tgt cca gcc ttc cat gag atg tgc agg gat gag tac 721 Ser Glu Lys Arg Cys Pro Ala Phe His Glu Met Cys Arg Asp Glu Tyr 225 230 235 240 gtg atg ctg atg acg tgg aag aag gca gct gct ggc gag atc atc tac 769 Val Met Leu Met Thr Trp Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr 245 250 255 aac aag tgc ccc ccg aat gcc tca ggg tct gcc agc cgc cgc tgt ctc 817 Pron Lys Asn Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu 260 265 270 ctc agt gcc caa ggc gtg gcg tac tgg ggg ctg ccc agc ttt gct cgc 865 Leu Ser Ala Gln Gly Val Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg 275 280 tgc atc tcc cat gag tac cgc tac ctg tat ctg tca ctt agg gag cac 913 Cys Ile Ser His Glu Tyr Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His 290 295 300 ctg gcc aag ggg cag cgc atg ctg gca ggc gg gg cag gtg 961 Leu Ala Lys Gly Gln Arg Met Leu Ala Gly Glu Gly Met Ser Gln Val 305 310 315 320 gtg cgc agc ctg cag gag cta ctg gcc cgg cgc acc tac tat agt ggg 1009 Val Arg Ser Leu Gln Glu Leg Leu AlaArg Thr Tyr Tyr Ser Gly 325 330 335 gac ctg ctc ttc tct gtg gac att ctg agg aat gtc act gac acc ttt 1057 Asp Leu Leu Phe Ser Val Asp Ile Leu Arg Asn Val Thr Asp Thr Phe 340 345 350 350 aag agg gcc acc tac gtg ccc tcg gct gat gat gtg cag cgc ttc ttc 1105 Lys Arg Ala Thr Tyr Val Pro Ser Ala Asp Asp Val Gln Arg Phe Phe 355 360 365 cag gtg gtg agc ttc atg gtg gat gcg gaa aac aag gag aag gag tag Val Ser Phe Met Val Asp Ala Glu Asn Lys Glu Lys Trp Asp 370 375 380 gat gct cag cag gtg tcc cct ggc tct gtg cac ctg ctc cgt gtc gtg 1201 Asp Ala Gln Gln Val Ser Pro Gly Ser Val His Leu Leu Arg Val Val 385 390 395 400 gag gac ttc att cac ctg gtg ggc gat gct ctc aag gcc ttc cag agc 1249 Glu Asp Phe Ile His Leu Val Gly Asp Ala Leu Lys Ala Phe Gln Ser 405 410 415 tct ctg att gtc acagtat atc agc att cag cga gag ccc 1297 Ser Leu Ile Val Thr Asp Asn Leu Val Ile Ser Ile Gln Arg Glu Pro 420 425 430 gtc tca gct gtg tcc agt gac atc acg ttc ccc atg cgg ggc cgc cgg 1345 Val Ser Ala Val Ser Ser Asp Ile Thr Phe Pro Met Arg Gly Arg Arg 435 440 445 ggc atg aag gac tgg gtg cgg cac tca gag gac cgc ctc ttc ctg ccc 1393 Gly Met Lys Asp Trp Val Arg His Ser Glu Asp Arg Leu Phe Leu Pro 450 455 aag gag gtg ctc agc ctc tcc tcc cca ggg aag cca gcc aca tct ggg 1441 Lys Glu Val Leu Ser Leu Ser Ser Pro Gly Lys Pro Ala Thr Ser Gly 465 470 470 475 480 gca gca ggc agc cct ggc agg ggg agg acg cca gtg cct cct 1489 Ala Ala Gly Ser Pro Gly Arg Gly Arg Gly Pro Gly Thr Val Pro Pro 485 490 495 ggc cca ggc cac tcc cac cag cgc ctc ctc cca gca gac cct gat gag 1537 Gly Pro Gly His Ser His Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu 500 505 510 tcc tcc tac ttt gtg atc ggt gct gta ctc tac cgc acc ctt ggc ctc 1585 Ser Ser Tyr Phe Val Ile Gly Ala Val Leu Tyr Arg Thr Leu Gly Leu 515 520 525 atc ctg ccg cct agg ccc ccg ctg gcc gtc aca tcc cgg gtg atg 1633 Ile Leu Pro Pro Pro Arg Pro Pro Leu Ala Val Thr Ser Arg Val Met 530 535 540 aca gtg act gtg cgc ccc cct acc cag cct cca gct gag ccc ctc atc 1681 T hr Val Thr Val Arg Pro Pro Thr Gln Pro Pro Ala Glu Pro Leu Ile 545 550 555 560 act gtg gag ctc tcc tac atc atc aat ggg acc acg gat ccc cat tgc 1729 Thr Val Glu Leu Ser Tyr Ile Ile Asn Gly Thr Thr Asp Pro His Cys 565 570 575 gcc agc tgg gac tac tcc aga gca gat gcc agc tca gga gac tgg gac 1777 Ala Ser Trp Asp Tyr Ser Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp 580 585 590 act gaa aat tgc cag acc ctg gag acc cag gca gct cac acc cgc tgc 1825 Thr Glu Asn Cys Gln Thr Leu Glu Thr Gln Ala Ala His Thr Arg Cys 595 600 605 cag tgc cag cac ctg tcc acc ttt gct gta cta gcc cag ccg ccc aag 1873 Gln Cys Gln His Leu Ser Thr Phe Ala Val Leu Ala Gln Pro Pro Lys 610 615 620 gac ctg acc ctg gag ctg gcg ggc tcc ccc tcg gtc ccc ctg gtg atc 1921 Asp Leu Thr Leu Glu Leu Ala Gly Ser Pro Ser Val Pro Leu Val Ile 625 630 635 640 ggc tgt gca gtg tcg tgc atg gcg ctg ctc acc ctg ctc gcc atc tat 1969 Gly Cys Ala Val Ser Cys Met Ala Leu Leu Thr Leu Leu Ala Ile Tyr 645 650 655 gcc gcc ttt tgg agg ttc ata ga tc c atc atc ttg ctg 2017 Ala Ala Phe Trp Arg Phe Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu 660 665 670 aac ttc tgc ctg tcc atc ttg gca tcc aac atc ctg atc ctc gtg ggc 2065 Asn Ple Lesu Le Ser Asn Ile Leu Ile Leu Val Gly 675 680 685 cag tcc cgg gtg ctg agc aag ggc gtg tgc acc atg acg gct gcc ttc 2113 Gln Ser Arg Val Leu Ser Lys Gly Val Cys Thr Met Thr Ala Ala Phe 690 695 700 ctg cac tt ttc ttt ctc tcc tcc ttt tgc tgg gtg ctt acc gag gcc 2161 Leu His Phe Phe Phe Leu Ser Ser Phe Cys Trp Val Leu Thr Glu Ala 705 710 710 720 tgg cag tcc tac ctg gct gtc att ggg cgg atg cgc acc cgc 2209 Trp Gln Ser Tyr Leu Ala Val Ile Gly Arg Met Arg Thr Arg Leu Val 725 730 735 cgc aag cgc ttc ctc tgc ctg ggc tgg ggt ctg cct gcc ctg gtg gtg 2257 Arg Lys Arg Phe Leu Cys Leu Gly Tly Leu Val Val 740 745 750 gcc gtg tct gtt ggc ttt acc cga acg aaa gga tac ggt aca tcc agc 2305 Ala Val Ser Val Gly Phe Thr Arg Thr Lys Gly Tyr Gly Thr Ser Ser 755 760 765 tac tgc tgg ctc tcc ctg gag ggc ggc ctg ctc tac gcc ttt gtg ggc 2353 Tyr Cys Trp Leu Ser Leu Glu Gly Gly Leu Leu Tyr Ala Phe Val Gly 770 775 780 cct gca gcc gtc att gtc ctg gtg aac atg ctc atc gga atc Atc Aga atc Aga gtc atc Aga gt Ile Val Leu Val Asn Met Leu Ile Gly Ile Val 785 790 795 800 ttc aac aag ctc atg gca cgt gat ggc atc tcc gac aaa tcc aag aag 2449 Phe Asn Lys Leu Met Ala Arg Asp Gly Ile Ser Asp Lys Ser Lys Lys 805 810 815 cag agg gcc ggg tcg gag cgg tgc ccc tgg gcc agc ctg ctc ctc ccc 2497 Gln Arg Ala Gly Ser Glu Arg Cys Pro Trp Ala Ser Leu Leu Leu Pro 820 825 830 tgc tca gcg tgt gga gcg cc ccc agc tca gcc tcg 2545 Cys Ser Ala Cys Gly Ala Val Pro Ser Pro Leu Leu Ser Ser Ala Ser 835 840 845 gcc agg aac gcc atg gcc tca ctc tgg agc tcc tgc gtg gtg ctg ccc 2593 Ala Arg Asn Ala Tet Ala Seru Ser Ser Cys Val Val Leu Pro 850 855 860 ctg ctg gcg ctc acc tgg atg tct gcc gtc ctg gct atg aca gac cgc 2641 Leu Leu Ala Leu Thr Trp Met Ser Ala Val Leu Ala Met Thr Asp Arg 865 870 875 875 880 cgt tcc gtc ctc ttc cag gcc ctc ttt gct gtc ttc aac tcc gcg cag 2689 Arg Ser Val Leu Phe Gln Ala Leu Phe Ala Val Phe Asn Ser Ala Gln 885 890 895 gggc ttt gtc atc act gct gtg gc cc ctc gc gc cc tgc gc cc ctc cag 2737 Gly Phe Val Ile Thr Ala Val His Cys Phe Leu Arg Arg Glu Val Gln 900 905 910 gat gtg gtg aag tgc cag atg ggg gtg tgc cgg gct gat gag agc gaa 2785 Asp Val Val Lys Cys Gln Met Gly Val Cys Arg Ala Asp Glu Ser Glu 915 920 925 gac tcc cct gac tcg tgt aag aac ggg cag ctg cag atc ctg tca gac 2833 Asp Ser Pro Asp Ser Cys Lys Asn Gly Gln Leu Gln Ile Leu Ser Asp 930 935 940 ttt gaa aag gat gtg g gct tgt caa aca gtg ctg ttc aag gag 2881 Phe Glu Lys Asp Val Asp Leu Ala Cys Gln Thr Val Leu Phe Lys Glu 945 950 955 960 gtc aac act tgc aac ccg tcc acc atc acg ggc aca cta tcc cgc Ascg 2929 Cys Asn Pro Ser Thr Ile Thr Gly Thr Leu Ser Arg Leu 965 970 975 tcc ctg gat gag gat gag gag ccc aag tcc tgc ctc gtg ggc cct gag 2977 Ser Leu Asp Glu Asp Glu Glu Pro Lys Ser Cys Leu Val Gly Pro G lu 980 985 990 ggc agc ctc agc ttc tca cca ctg cct ggg aat atc ctg gtg ccc atg 3025 Gly Ser Leu Ser Phe Ser Pro Leu Pro Gly Asn Ile Leu Val Pro Met 995 1000 1005 gca gcc tca cca ggg ctg ggg gag cgg ccc cca cag gag gcc aac 3073 Ala Ala Ser Pro Gly Leu Gly Glu Pro Pro Pro Pro Gln Glu Ala Asn 1010 1015 1020 cct gtt tac atg tgt ggg gag ggt ggc ctg cgg cag ctg gac ctc aca 3121 Pro Val Tyr Met Cys Gly Glu Gly Gly Leu Arg Gln Leu Asp Leu Thr 1025 1030 1035 1040 tgg ctg cgg ccc act gag cca ggc tct gag gga gac tac atg gtg ctg 3169 Trp Leu Arg Pro Thr Glu Pro Gly Ser Glu Gly Asp Tyr Met Val Leu 1045 1050 1055 c cgg cgg act ttg agc ctg cag cct ggc ggt ggg ggt gga ggt ggt 3217 Pro Arg Arg Thr Leu Ser Leu Gln Pro Gly Gly Gly Gly Gly Gly Gly Gly 1060 1065 1070 gag gat gcc ccc agg gcc cgg ccg gag ggg acc ccc cgg gga gcc 3265 Glu Asp Ala Pro Arg Ala Arg Pro Glu Gly Thr Pro Arg Arg Ala Ala 1075 1080 1085 aag aca gtg gcc cac act gaa ggc tac ccc agc ttc ctg tcc gtg gac 3313 Lys Thr Val Ala His Th r Glu Gly Tyr Pro Ser Phe Leu Ser Val Asp 1090 1095 1100 cac tcg ggc ctg ggg ctg ggc cct gcc tat gga tct ctc cag aat ccc 3361 His Ser Gly Leu Gly Leu Gly Pro Ala Tyr Gly Ser Leu Gln Asn Pro 1105 1110 1115 1120 tat gga atg acc ttc caa ccg cca ccg ccg aca ccc agc gcc cgc caa 3409 Tyr Gly Met Thr Phe Gln Pro Pro Pro Pro Thr Pro Ser Ala Arg Gln 1125 1130 1135 gtg ccc gag cca ggg gag cgc agc cgg acc atc cct acc gtg ccc 3457 Val Pro Glu Pro Gly Glu Arg Ser Arg Thr Met Pro Arg Thr Val Pro 1140 1145 1150 ggc tct acc atg aag atg ggc tcc ctg gag cga aag aaa tta cgg tat 3505 Gly Ser Thr Met Lys Met Gly Ser Leu Glu Arg Lys Lys Leu Arg Tyr 1155 1160 1165 tca gac ctg gac ttt gag aag gtg atg cac acc cgg aaa cgg cat tca 3553 Ser Asp Leu Asp Phe Glu Lys Val Met His Thr Arg Lys Arg His Ser 1170 1175 1180 gaa ctc tac cac gag ctc aac cag aag ttc cac act ttc gac cgc tac 3601 Glu Leu Tyr His Glu Leu Asn Gln Lys Phe His Thr Phe Asp Arg Tyr 1185 1190 1195 1200 cgc agc cag tcc acg gcc aag agg gag aag cgg t gg agt gtg tcc tcg 3649 Arg Ser Gln Ser Thr Ala Lys Arg Glu Lys Arg Trp Ser Val Ser Ser 1205 1210 1215 ggt ggg gcg gcc gag cgg agc gtg tgc acc gat aag ccc agc cct ggg 3697 Gly Gly Ala Ala Glu Arg Ser Cys Thr Asp Lys Pro Ser Pro Gly 1220 1225 1230 gag cgc ccc agc ttg tcc caa cat cgg cgc cat cag agc tgg agc acc 3745 Glu Arg Pro Ser Leu Ser Gln His Arg Arg His Gln Ser Trp Ser Thr 1235 1240 1245 ttc aaa tct atg aca ctg ggc tcg ctg ccc ccc aag ccc cga gaa cgg 3793 Phe Lys Ser Met Thr Leu Gly Ser Leu Pro Pro Lys Pro Arg Glu Arg 1250 1255 1260 ctg act ctg cac cgg gca gca gcc tgg gag ccc aca gaa ccacc Leu Thr Leu His Arg Ala Ala Ala Trp Glu Pro Thr Glu Pro Pro Asp 1265 1270 1275 1280 ggt gac ttc cag aca gag gtg tgagtgccac gctggactgc ccactgcata 3892 Gly Asp Phe Gln Thr Glu Val 1285 taaatatata tatccgcc cctgcc cctg cctccc cctg ccg actcagccag gctgggggag 4012 ccggacatgg cttggcctgg ggtcccaggg cccttccttg tttctcagag gcc cctcagc 4072 cactggaacc ccatcttcag cccagcctgt ccgtccctgt cccgggctgg ggagggggga 4132 ggggaacttt gttgggaata aacttcactc tgtgg 4167 <210> 185 <211> 4293 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2392) <400> 185 g ggc gcc ttc agc gcc agc ctc ttc gct ccg tcc aag ccg cag cgc cgc 49 Gly Ala Phe Ser Ala Ser Leu Phe Ala Pro Ser Lys Pro Gln Arg Arg 1 5 10 15 aag agc ccc ctg gtg ag cag cag gtg gag gac gcg cag gag cgc 97 Lys Ser Pro Leu Val Lys Gln Leu Gln Val Glu Asp Ala Gln Glu Arg 20 25 30 gcg gcc ctg gcc gtg ggc agc ccc ggt ccc ggc ggc ggc agc ttc gla Ala Ala Ala Gly Ser Pro Gly Pro Gly Gly Gly Ser Phe Ala 35 40 45 cgc gag ccc tcc ccg acc cac cgc ggt ccg cgc ccg ggt ggc ctc gac 193 Arg Glu Pro Ser Pro Thr His Arg Gly Pro Arg Pro Gly Gly Gly Leu Asp 50 55 60 tac ggc gcg ggc gat ggc ccg ggg ctc gcg ttc ggc ggc ccg ggc ccg 241 Tyr Gly Ala Gly Asp Gly Pro Gly Leu Ala Phe Gly Gly Pro Gly Pro 65 70 75 80 gcc aag gac cgg cgg ctg gag cag cg cg cg cg gg gtg ttc ctg 289 Ala Lys Asp Arg Arg Leu Glu Glu Arg Arg Arg Ser Thr Val Phe Leu 85 90 95 tcc gtg ggg gcc atc gag ggc agc gcc ccc ggc gcg gat ctg cca tcc 337 Ser Val Gly Ala Ile Glu Gly Ser Ala Gly Ala Asp Leu Pro Ser 100 105 110 cta cag ccc tcc cgc tcc atc gac gag cgc ctc ctg ggg acc ggc ccc 385 Leu Gln Pro Ser Arg Ser Ile Asp Glu Arg Leu Leu Gly Thr Gly Pro 115 120 125 acc gcc ggc cgc gac ctg ctg ctg ccc tcc ccg gcc ctg aag 433 Thr Ala Gly Arg Asp Leu Leu Leu Pro Ser Pro Val Ser Ala Leu Lys 130 135 140 ccg ttg gtc agc ggc ccg agc ctg ggg ccc tcg ggt tcc acc ttc atc 481 Pro Leu Val Ser Gly Pro Ser Leu Gly Pro Ser Gly Ser Thr Phe Ile 145 150 155 160 cac cca ctc acc ggc aaa ccc ctg gac ccc agc tca ccc ctg gcc ctt 529 His Pro Leu Thr Gly Lys Pro Leu Asp Pro Ser Ser Pro Leu Ala Leu 165 170 175 gcc ctg gct gcc cga gag cga gct ctg gcc tcc cag gcg ccc tcc cgg 577 Ala Leu Ala Ala Arg Glu Arg Ala Leu Ala Ser Gln Ala Pro Ser Arg 180 185 190 tcc ccc aca ccc gtg cac agt ccc gac gcc gac cgc ccc gga ccc ctg 625 Pro Thr Pro Val His Ser Pro Asp Ala Asp Arg Pro Gly Pro Leu 195 200 205 ttt gtg gat gta cag gcc cgg gac cca gag cga ggg tcc ctg gct tcc 673 Phe Val Asp Val Gln Ala Arg Asp Pro Glu Arg Gly Ser Leu Al a Ser 210 215 220 ccg gct ttc tcc cca cgg agc cca gcc tgg att cct gtg cct gct cgc 721 Pro Ala Phe Ser Pro Arg Ser Pro Ala Trp Ile Pro Val Pro Ala Arg 225 230 235 240 agg gag gca gag aag gtc ccc cgg gag gag cgg aag tca ccc gag gac 769 Arg Glu Ala Glu Lys Val Pro Arg Glu Glu Arg Lys Ser Pro Glu Asp 245 250 255 aag aag tcc atg atc ctc agc gtc ctg gac aca tcc ctg cag cgg cca 817 Lys Lys Ser Met Leu Ser Val Leu Asp Thr Ser Leu Gln Arg Pro 260 265 270 gct ggc ctc atc gtt gtg cac gcc acc agc aac ggg cag gag ccc agc 865 Ala Gly Leu Ile Val Val His Ala Thr Ser Asn Gly Gln Glu Pro Ser 275 280 285 agg ctg ggg ggg gcc gaa gag gag cgc ccg ggc acc ccg gag ttg gcc 913 Arg Leu Gly Gly Ala Glu Glu Glu Arg Pro Gly Thr Pro Glu Leu Ala 290 295 300 ccg gcc ccc atg cag tca gcg gct ccc gca agc ccc 961 Pro Ala Pro Met Gln Ser Ala Ala Val Ala Glu Pro Leu Pro Ser Pro 305 310 315 320 cgg gcc cag ccc cct ggt ggc acc ccg gca gac gcc ggg cca ggc cag 1009 Arg Ala Gln Pro Pro Gly Gly Thr Pro AlaAsp Ala Gly Pro Gly Gln 325 330 335 ggc agc tca gag gaa gag cca gag ctg gtg ttt gct gtg aac ctg cca 1057 Gly Ser Ser Glu Glu Glu Glu Pro Glu Leu Val Phe Ala Val Asn Leu Pro 340 345 350 cct gcc cag ctg tcc agc gat gag gag acc agg gag gag ctg gcc 1105 Pro Ala Gln Leu Ser Ser Ser Asp Glu Glu Thr Arg Glu Glu Leu Ala 355 360 365 cga att ggg ttg gtg cca ccc cct gaa gag ttt gcc aac ggg gtc ctg 1153 Arg Gly Leu Val Pro Pro Pro Glu Glu Phe Ala Asn Gly Val Leu 370 375 380 ctg gcc acc cca ctc gct ggc ccg ggc ccc tcg ccc acc acg gtg ccc 1201 Leu Ala Thr Pro Leu Ala Gly Pro Gly Pro Ser Pro Thr Thr Val Val Pro 385 390 395 400 agc ccg gcc tca ggg aag ccc agc agt gag cca ccc cct gcc cct gag 1249 Ser Pro Ala Ser Gly Lys Pro Ser Ser Glu Pro Pro Pro Ala Pro Glu 405 410 415 tct gca gcc gac tct ggg gtg gag gag gct gac aca cgc agc tcc agc 1297 Ser Ala Ala Asp Ser Gly Val Glu Glu Ala Asp Thr Arg Ser Ser Ser 420 425 430 gac ccc cac ctg gag acc aca agc acc atc tcc acg gtg tcc agc atg 1345 Asp Pro His Leu Glu Tlu hr Thr Ser Thr Ile Ser Thr Val Ser Ser Met 435 440 445 tcc acc ttg agc tcg gag agc ggg gaa ctc act gac acc cac acc tcc 1393 Ser Thr Leu Ser Ser Glu Ser Gly Glu Leu Thr Asp Thr His Thr Ser 450 455 460 ttc gct gac gga cac act ttt cta ctc gag aag cca cca gtg cct ccc 1441 Phe Ala Asp Gly His Thr Phe Leu Leu Glu Lys Pro Pro Val Pro Pro 465 470 475 475 480 aag ccc aag ctc aag tcc ccg ctg ggg aag ggg ccg acc ttc agg 1489 Lys Pro Lys Leu Lys Ser Pro Leu Gly Lys Gly Pro Val Thr Phe Arg 485 490 495 gac ccg ctg ctg aag cag tcc tcg gac agc gag ctc atg gcc cag cag 1537 Asp Pro Leu Leu Lys Gln Ser Ser Asp Ser Glu Leu Met Ala Gln Gln 500 505 510 cac cac gcc gcc tct gcc ggg ctg gcc tct gcc gcc ggg cct gcc cgc 1585 His His Ala Ala Ser Ala Gly Leu Ala Ser Ala Ala Gly Pro Ala Arg 515 520 525 cct cgc tac ctc ttc cag aga agg tcc aag cta tgg ggg gac ccc gtg 1633 Pro Arg Tyr Leu Phe Gln Arg Arg Ser Lys Leu Trp Gly Asp Pro Val 530 535 540 gag agc cgg ggg ctc cct ggg cct gaa gac gac aaa cca act gtg atc 1681 u Ser Arg Gly Leu Pro Gly Pro Glu Asp Asp Lys Pro Thr Val Ile 545 550 555 560 agt gag ctc agc tcc cgc ctg cag cag ctg aac aag aac gac acg cgt tcc 1729 Ser Glu Leu Ser Ser Arg Leu Gln Gln Leu Asn Lys Asp Thr Arg Ser 565 570 575 ctg ggg gag gaa cca gtt ggt ggc ctg ggc agc ctg ctg gac cct gcc 1777 Leu Gly Glu Glu Pro Val Gly Gly Leu Gly Ser Leu Leu Asp Pro Ala 580 585 585 590 aag aag tcg gcc atc gc cgg ctc ttc agc agc ctc ggt gag 1825 Lys Lys Ser Pro Ile Ala Ala Ala Arg Leu Phe Ser Ser Leu Gly Glu 595 600 605 ctg agc tcc att tca gcg cag cgc agc ccc ggg ggc ccg ggc Legg Sergg 1 Ala Gln Arg Ser Pro Gly Gly Pro Gly Gly Gly 610 615 620 gcc tcg tac tcg gtg agg ccc agt ggc cgc tac ccc gtg gcg aga cgc 1921 Ala Ser Tyr Ser Val Arg Pro Ser Gly Arg Tyr Pro Val Ala Arg Arg 630 630 640 gcc ccg agc ccg gtg aag ccc gcg tcg ctg gag cgg gtg gag ggg ctg 1969 Ala Pro Ser Pro Val Lys Pro Ala Ser Leu Glu Arg Val Glu Gly Leu 645 650 655 655 ggg gcg ggc gcg ggg ggc gca ggg cgg c ctc acg ccc ccc 2017 Gly Ala Gly Ala Gly Gly Ala Gly Arg Pro Phe Gly Leu Thr Pro Pro 660 665 670 acc atc ctc aag tcg tcc agc ctc tcc atc ccg cac gag ccc aag gag 2065 Thr Ile Leu Lys Ser Ser Ser Leu Ser Ile Pro His Glu Pro Lys Glu 675 680 685 gtg cgc ttc gtg gtg cgc agc gtg agc gcg cgc agt cgc tcc ccc tcg 2113 Val Arg Phe Val Val Arg Ser Val Ser Ala Arg Ser Arg Ser Pro Ser 690 695 700 ccg tc ctg ccc tcg ccc gcg tcc ggc ccc ggc ccc ggc gcc ccc 2161 Pro Ser Pro Leu Pro Ser Pro Ala Ser Gly Pro Gly Pro Gly Ala Pro 705 710 715 720 ggc cca cgc cga ccc ttc cag cag aag ccg ctg agg ccg agg 2209 Gly Pro Arg Arg Pro Phe Gln Gln Lys Pro Leu Gln Leu Trp Ser Lys 725 730 735 ttc gac gtg ggc gac tgg ctg gag agc atc cac cta ggc gag cac cgc 2257 Phe Asp Val Gly Asp Trp Leu Glu Serly His Leu Le Glu His Arg 740 745 750 gac cgc ttc gag gac cat gag ata gaa ggc gcg cac cta ccc gcg ctt 2305 Asp Arg Phe Glu Asp His Glu Ile Glu Gly Ala His Leu Pro Ala Leu 755 760 760 acc acc aag gac gac gtt g ctg ggc gtc acg cgc gtg ggc cac cgc 2353 Thr Lys Asp Asp Phe Val Glu Leu Gly Val Thr Arg Val Gly His Arg 770 775 780 atg aac atc gag cgc gcg ctc agg cag ctg gac ggc agc Agcggg AscAgcccgcgcgcgcgcgccc Leu Arg Gln Leu Asp Gly Ser 785 790 795 cccccactcc cgccccggcc gtgccctgcc ggcagggccc cccaccccca ccccgggccg 2462 cgggctcggc ctgcccctta cgacggcgcc cgggccagga atgttgcatg aatcgtcctg 2522 tttgctgttg ctcggagact cgccctgtac attgcttagt gccctcaccg gccgcccagc 2582 ccacccagcg cacagtcagg aagggcgtgg accagggagg ctggggcggg aggtgccggg 2642 ggtggggtgc cctagcgtga ccacctcctt cgcagctcct ggtggccatt ctcccagagg 2702 gggaacctag tccagcatgc gaggtcagga cccgccttgg tgactcgggg ggagggggga 2762 gacattggga ttctcgatgg gggccaagga gcccccctgt tttgcatatt ttaatccact 2822 ctatatttgg aacgagaaaa ggaacaaata tctctgtccg taatagtttc ctctcccctc 2882 ccttctactt ccactggtcc cactgcagct gcccagtctt ccatctccgg cccctcactg 2942 ccactgccac cccacaacgg ggcaggggac gctccagctg gtctggggtt ggccagggcc 3002 ctagtggccc gccctggggc cccagctcgg cccctc gcct cgctgagctc tagtgtgccc 3062 caccgaccct tcaggtgctg ctcgtggtgg gaggggcggc aggccgcggg tcctgctgtg 3122 cacccgcggg accagccggc ctgggagacc atcggccggg ggggatgagg gcagggccct 3182 gccgctccac cgcagccatc ttcctcacag ggtctctccc caaggagggg gctagcttgg 3242 tccccatgct cttgggcaac tacagcagag aagcctccct gccttggacc ccaaagtctc 3302 ctgtcctgcc ctttatgtgt gtgggtgaaa ctgggtgcgt ctgagcacgt gggagccgtg 3362 tgtgtgcctg attactgagt ggccaccagg ggccgctctg gactagcgcg gggccgtgga 3422 ggcgtgcacc gtgtgcatgc gtggggtgta cctgtgagag caccctgtct cctcttccaa 3482 agaaagtcag aggccatcct gcaccctggg tccagctgtt tgcccagcct gtccttccag 3542 agcctcaccc agcctgagcg gggttccctg gtgaatccct gctgcttggg gaggccccaa 3602 gggccccttg gaggcagcgc ccccaccttg ggcttctgag ggcatcatag ggggacccct 3662 agagtcagtt caccacaggc cctggggaga gtcaaagacc cccgagggtg cccagccccc 3722 cacactgtga ctcctcacac tcagcgatga cctgtggggt ggggggccct gggacgtttt 3782 taaacctagg gtttggagtc tggactaagc tccatccacg tcactcacaa gtttctgttt 3842 atatttctag ctttttttaa taaaataaaa aaaaaaagaa a acagaagtt ttcacaaccc 3902 aggggcctgg cacgccggtc tgtgcctgcc cgccccgccc tggcccaccg gccccactcc 3962 ctgggcacag agtcacaccc actcatcctt ccgccaacag tccaggtcac acagcagcag 4022 tcactgtaac agactgccac atacacactc ggtctcacac tcacctgtgg gttttggttc 4082 cgttcaattt gggtttttaa ctttacaggg tcagttccgc ttcacctcct tttgtatgga 4142 gttccatcca gggggtttca ccccctgctc cagtcctgag gcctcctgac cctgacgttg 4202 tgatacgccc cacagagatc tatgtttctt atattattat tattgataat aattattata 4262 atattattat gtaataaatt tataagaaat g 4293 <210> 186 <211> 4624 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2737) <400> 186 a gag gcc tca gcg gcc ctg cag gtc cgg gcg acc aag gat tat tgc aac 49 Glu Ala Ser Ala Ala Leu Gln Val Arg Ala Thr Lys Asp Tyr Cys Asn 1 5 10 15 aat tac gac ctg acc agc ctc aac gtg aag gca ggg gac atc atc aca 97 Asn Tyr Asp Leu Thr Ser Leu Asn Val Lys Ala Gly Asp Ile Ile Thr 20 25 30 gtc ctc gag cag cat ccg gat ggc cgg tgg aag ggc tgc atc cat gac 145 Val Leu Glu Gln His His Pro Asp Gly Arg Trp Lys Gly Cys Ile His Asp 35 40 45 aac cgg acg ggc aat gac cgg gtg ggc tac ttc ccg tcc tcc ctg ggc 193 Asn Arg Thr Gly Asn Asp Arg Val Gly Tyr Phe Pro Ser Ser Leu Gly 50 55 60 gag gcc att gtc aag cga gca ggt tcc cga gca ggc act gaa cca agc 241 Glu Ala Ile Val Lys Arg Ala Gly Ser Arg Ala Gly Thr Glu Pro Ser 65 70 75 80 ctg ccc cag gga agc agc tca tcg gga ccc tct gcc cca gag gag 289 Leu Pro Gln Gly Ser Ser Ser Ser Gly Pro Ser Ala Pro Pro Glu Glu 85 90 95 atc tgg gtg ctg agg aag cct ttt gca ggt ggg gac cga agc ggc agc 337 Ile Trp Val Leu Arg Lys Pro Phe Ala Gly Gly Asp Arg Ser Gly Ser 100 105 110 att agc ggc atg gct ggc ggc cgg ggc agc ggg ggt cac gcc cta cac 385 Ile Ser Gly Met Ala Gly Gly Arg Gly Ser Gly Gly His Ala Leu His 115 120 125 gcg ggc tct gaa ggc gtc aag ctc gc tcc cag aag 433 Ala Gly Ser Glu Gly Val Lys Leu Leu Ala Thr Val Leu Ser Gln Lys 130 135 140 tcc gtc tct gag tcc ggc ccg ggg gac agc ccc gcc aag cct ccg gaa 481 Ser Val Ser Glu Ser Gly Pro Gly Asp Ser Pro Ala Lys Pro Pro Glu 145 150 155 160 ggc tct gca ggt gtg gcc cgg tcc cag cct cca gtg gcc cac gcc ggg 529 Gly Ser Ala Gly Val Ala Arg Ser Gln Pro Pro Val Ala His Ala Gly 165 170 175 cag gtc tat ggg gag cag ccg ccc aag aag ctg gag cca gca tcg gag 577 Gln Val Tyr Gly Glu Gln Pro Pro Lys Lys Leu Glu Pro Ala Ser Glu 180 185 190 ggc aag gct aac ctg gcc gtg tgg ctg tcc atg atc ggc ctg gcc cag Lys Ala Asn Leu Ala Val Trp Leu Ser Met Ile Gly Leu Ala Gln 195 200 205 tac tac aag gtg ttg gtg gac aat ggc tac gag aac att gat ttc atc 673 Tyr Tyr Lys Val Leu Val Asp Asn Gly Tyr Glu Asn Ile Asp Ile 210 215 220 acc gac atc acc tgg gag gac ctg cag gag atc ggc atc acc aag ctg 721 Thr Asp Ile Thr Trp Glu Asp Leu Gln Glu Ile Gly Ile Thr Lys Leu 225 230 235 240 ggg cac cag aag aag ctg atg ctc gct gtg agg aag ctg gca gag ctg 769 Gly His Gln Lys Lys Leu Met Leu Ala Val Arg Lys Leu Ala Glu Leu 245 250 255 cag aag gct gaa tac gcc aag tat gag ggg ggc ccc ctg cgc cgg aag 817 Gln Lys Ala Gla Lyra Lys Tyr Glu Gly Gly Pro Leu Arg Arg Lys 260 265 270 gcg ccc cag tct ctt gaa gtg atg gcc atc gag tcg ccg ccc ccg cct 865 Ala Pro Gln Ser Leu Glu Val Met Ala Ile Glu Ser Pro Pro Pro Pro 275 280 285 gag ccc aca ccg gcc gac tgc cag tcc cct aaa atg acc acc ttc cag 913 Glu Pro Thr Pro Ala Asp Cys Gln Ser Pro Lys Met Thr Thr Phe Gln 290 295 300 gac agc gag ctc agt gac gag ctg cag gct gcc atg act ggc ccg gct 961 Asp Ser Glu Leu Ser Asp Glu Leu Gln Ala Ala Met Thr Gly Pro Ala 305 310 315 320 gag gtg ggg ccc acc act gag aag ccc tcc agc cac ctg cca ccc acc 1009 Glu Val Gly Pro Thr Thr Glu Lys Pro Ser Ser His Leu Pro Pro Thr 325 330 335 ccg agg gcc acc acg cgg cag gac tcc agc ctg ggt ggt cgg gca cgg 1057 Pro Arg Ala Thr Thr Arg Gln Asp Ser Ser Leu Gly Gly Arg Ala Arg 340 345 350 cac atg agc agc tcg cag gag ctg ctg gga gat ggg ccc cct ggg ccc 1105 His Met Ser Ser Ser Gln Glu Leu Leu Gly Asp Gly Pro Pro Gly Pro 355 360 365 agc agc ccc atg tct cga agc cag gag tac ctc ctg gat gag ggc ccc 1153 Ser Pro Met Ser Arg Ser Gln Glu Tyr Leu Leu Asp Glu Gly Pro 370 375 380 gcc ccc ggc acc ccg ccc agg gag gcc cgg ccc ggc cgc cac ggc cac 1201 Ala Pro Gly Thr Pro Pro Arg Glu Ala Arg Pro Gly Arg His Gly His 385 390 395 400 agc atc aag agg gcc agc gtg ccc ccc gtg cct ggc aag cca cgg cag 1249 Ser Ile Lys Arg Ala Ser Val Pro Pro Val Pro Gly Lys Pro Arg Gln 405 410 415 gtc ctc cca cca ggc act agc cacttc ccc ccc cag acg ccc acc 1297 Val Leu Pro Pro Gly Thr Ser His Phe Thr Pro Pro Gln Thr Pro Thr 420 425 430 aaa acc cga cca ggc tct ccc cag gcc ctt ggg gga cct cat ggt cca 1345 Lys Thr Arg Pro Gly S er Pro Gln Ala Leu Gly Gly Pro His Gly Pro 435 440 445 gcc cca gct acg gcc aag gtg aag ccc acc ccg cag ctg ctg ccg ccg 1393 Ala Pro Ala Thr Ala Lys Val Lys Pro Thr Pro Gln Leu Leu Pro Pro 450 455 460 aca gag cgc ccc atg tca ccc cgc tcc ctg cct cag tca ccg acg cac 1441 Thr Glu Arg Pro Met Ser Pro Arg Ser Leu Pro Gln Ser Pro Thr His 465 470 475 475 480 cgc ggc ttt gcc tac gtg ctg ccc cag ccc gtg gag gag gtg ggg 1489 Arg Gly Phe Ala Tyr Val Leu Pro Gln Pro Val Glu Gly Glu Val Gly 485 490 495 ccg gct gcc ccg ggg cct gcg ccc cca ccc gtg ccg acg gct gtg ccc 1537 Pro Ala Ala Pro Gly Pro Ala Pro Pro Pro Val Pro Thr Ala Val Pro 500 505 510 aca ctg tgc ctg ccc cct gag gcc gac gcg gag ccg ggg cgg ccc aag 1585 Thr Leu Cys Leu Pro Pro Glu Ala Asp Ala Glu Pro Gly Arg Pro Lys 515 520 525 525 aag cgg gcc cac agc ctg aat cgc tat gcg gcg tcc gac agc gag ccg 1633 Lys Arg Ala His Ser Leu Asn Arg Tyr Ala Ala Ser Asp Ser Glu Pro 530 535 540 gag cgg gac gag ctg ctg gtg cct gcg gct gcc ggc ccc tat gcc u Arg Asp Glu Leu Leu Val Pro Ala Ala Ala Gly Pro Tyr Ala Thr 545 550 555 560 gtc cag cgg cgc gtg ggc cgc agc cac tca gtg agg gcg ccc gca ggt 1729 Val Gln Arg Arg Val Gly Arg Ser His Ser Val Arg Ala Pro Ala Gly 565 570 575 gcc gac aag aac gtc aac cgc agc cag tcc ttt gcc gtg cgg ccc cga 1777 Ala Asp Lys Asn Val Asn Arg Ser Gln Ser Phe Ala Val Arg Pro Arg 580 585 590 aag aag ggg ccc ccg ccg ccc ccc aag cgc tcc agc tcg gcc ctg 1825 Lys Lys Gly Pro Pro Pro Pro Pro Lys Arg Ser Ser Ser Ala Leu 595 600 605 gct agt gcc aac ctg gcg gat gag ccg gtg cct gac gcc gag cct gag 1873 Ala Ser Ala Asn Leu Ala Asp Glu Pro Val Pro Asp Ala Glu Pro Glu 610 615 620 gat ggc ctg ctg ggg gtc cgg gca cag tgc cgg cgg gcc agt gac ctg 1921 Asp Gly Leu Leu Gly Val Arg Ala Gln Cys Arg Arg Ala Ser Asp Leu 630 640 gcc ggc agc gtg gac acg ggt agt gcc ggc agt gtg aag agc atc gcg 1969 Ala Gly Ser Val Asp Thr Gly Ser Ala Gly Ser Val Lys Ser Ile Ala 645 650 655 gcc atg ctg gag ctg tcc tcc att ggg ggt cgg gct gcc cgc 2017 Ala Met Leu Glu Leu Ser Ser Ile Gly Gly Gly Gly Arg Ala Ala Arg 660 665 670 agg cct cct gag ggc cac ccc act ccc cgc cct gcc agc cca gag ccg 2065 Arg Pro Pro Glu Gly His Pro Thr Pro Arg Pro Ala Ser Pro Glu Pro 675 680 685 ggc cgg gtg gcc acc gtg ctg gcc tca gtg aaa cac aaa gag gcc atc 2113 Gly Arg Val Ala Thr Val Leu Ala Ser Val Lys His Lys Glu Ala Ile 690 695 700 ggg cct ggc ggg gag gtg gtg aac cgg cgc cgc acg ctc agc ggg cca 2161 Gly Pro Gly Gly Glu Val Val Asn Arg Arg Arg Thr Leu Ser Gly Pro 705 710 715 715 720 gtc acc gga ctt ctg gcc act gcc cgc cgg ggg cct ggg gag tg Val Thr Gly Leu Leu Ala Thr Ala Arg Arg Gly Pro Gly Glu Ser Ala 725 730 735 gac cca ggc ccc ttt gtg gag gat ggc act ggc cgg cag cgg cct cgg 2257 Asp Pro Gly Pro Phe Val Glu Asp Gly Thr Gly Arg Gln Arg Pro Arg 740 745 750 ggt ccc tcc aag ggc gag gcg ggt gtc gaa ggc ccg ccc ttg gcc aag 2305 Gly Pro Ser Lys Gly Glu Ala Gly Val Glu Gly Pro Pro Leu Ala Lys 755 760 765 gtg gaa gcc agc gcc aca aag agg cgc atc cgg gcc aag cag aac 2353 Val Glu Ala Ser Ala Thr Leu Lys Arg Arg Ile Arg Ala Lys Gln Asn 770 775 780 cag cag gag aac gtc aag ttc atc ctg acc gag tct gac acg gtc aag Glu Gln Gln Val Lys Phe Ile Leu Thr Glu Ser Asp Thr Val Lys 785 790 795 800 cgc agg ccc aag gcc aag gag cgg gag gcc ggg cct gag cca cca ccg 2449 Arg Arg Pro Lys Ala Lys Glu Arg Glu Ala Gly Pro Glu Pro Pro Pro 805 810 815 cca ctg tcc gtg tac cat aat ggc act ggc acc gtg cgc cgc cga ccg 2497 Pro Leu Ser Val Tyr His Asn Gly Thr Gly Thr Val Val Arg Arg Arg Pro 820 825 830 gcc tcg gag cag gct ggg cct ccg gag ctg cct ccg ccc ccg cct 2545 Ala Ser Glu Gln Ala Gly Pro Pro Glu Leu Pro Pro Pro Pro Pro 835 840 845 gcc gaa ccc ccg ccc acc gac ctg gcg cac cta ccc cca ttg ccc ccg 2593 Ala Glu Pro Pro Thr Asp Leu Ala His Leu Pro Pro Leu Pro Pro 850 855 860 ccc gag ggc gaa cga agc ccg gaa gcc ggc caa gcc gcc tgt ctc tcc 2641 Pro Glu Gly Glu Glu Arg Ser Pro Glu Ala Gly Gln Ala Ala Cys Leu Ser 865 870 875 875 880 caa g cc cgt cct gac gca gcc tgt gcc caa gct cca ggg ctc gcc cac 2689 Gln Ala Arg Pro Asp Ala Ala Cys Ala Gln Ala Pro Gly Leu Ala His 885 890 895 acc caa cct cca aga agg tgc cgc tgc cag gcc ccg gca agg 2737 Thr Gln Pro Pro Arg Arg Cys Arg Cys Gln Ala Leu Ala Ala Gln Arg 900 905 910 tgaagcgcgc ccacggcacg ccaccgcccg tgtctcccaa gccgccgccg ccgcccacag 2797 cgcccaagcc cgtcaaggcg gtcgcggggc tgccttcggg cagcgccggc ccttcacccg 2857 caccctcgcc cgcgcgacag ccgcccgccg ccctcgccaa gccgcccggt acgccgccct 2917 cgctgggcgc cagccccgcc aagcccccgt cccccggcgc gcccgcgctg cacgtgcccg 2977 ccaagccccc gcgagccgcc gccgccgccg ccgccgccgc cgccgcgccc cccgccccgc 3037 ccgaaggcgc ctcgccaggg gacagcgccc ggcagaaact ggaggagaca agcgcgtgcc 3097 tggccgcggc gctgcaggcg gtggaggaga agatccggca ggaggacgcg cagggcccgc 3157 gcgactcggc ggcggaaaag agcactggca gcatcctgga cgacatcggc agcatgttcg 3217 acgacctggc cgaccagctg gatgccatgc tggagtgaac gccgcctggc cgggccctcc 3277 cgcgccgccc gggccctccc cgcacactga cctatacctc aggatgggcg cgtctgggcg 3337 cggc gcgagc ggccgggcag ggccctgcag aagcacaact ccggcccctg gacccgggcc 3397 ggggcgccca ccggggaccg cctggccggg ggctccaagg gctctaggca gaccctgcgc 3457 ccgcgggtcc tccccacctg ctgctccccg tgcaatacct gctgggcctc ctgcccgcgc 3517 gggaggggag ggcgccccgg gaccagggat ggggcagcgc acaggcccgg gcccagcaca 3577 gaactgccca tcgggacgcc cggccagccg ctcgggcgca gcacaaggga caggggacca 3637 aggtcagggc ccccctgccc caccgcaccc ccagaatata agctatcaag agtattaatt 3697 tattgggaat gagctgaggc ggatttcccc agagaaacaa aaaggtataa ctttaacaaa 3757 tatatattta aagaaagaaa tattattgat tctatagaaa accatttacc aactgaaagg 3817 acacgaagtc tagctccgga caaaagctgt tagaggccca ggctgtctgc ctgcggtcct 3877 tcctccggcc agagtggagg ccccaggctg ctagcacagg tggaaggctg gggcccgggg 3937 gcgggtgctc tgccgggggc tcctccgtgc ttctctccta agttctctgc gccccaagaa 3997 ctcgaggttg tgccttgctc tcggcggccg tgtcctcctc ctggcgtggc tgcgtcccag 4057 ggcgcgggtg ggtttggtga atgtgggtgt gtcagcgtgg cagccacgtg gaagcagggc 4117 atgtagcagg ccaggccacg ggcttgcagc tcctctgagg gtgtgcctgg ccccctctcc 4177 aggggctgtg caggcagccc atccacccca gtggagttcc cacggacgct tctgctcatg 4237 gtccaaggct gtgttgtgtg gtcattctcg ccctcccttt tcctctctcc tcctgccccc 4297 tccaagaagt actgactggt ctcctctatc gtgtttgctg atccacagtg ttgggcacaa 4357 ctttgacgtt tcttaaaaaa aaaatttaaa aaatgccgaa aaccagcgat tgtggtgtgg 4417 ggcgggtgga ggcggctggc ggaggtggcg tcccggcgtg cagggcccct tcctgctgtc 4477 tcaccccgtg tttccctgcg agtggacgtg cccagctgtc cccccaggcc tctcctcaga 4537 gggcggcaca ggctgggctc cagcaggtgg gcaggggagg tctgggcaag gcgctgccgt 4597 cggctgtcaa taaacagcag gaaacag 4624 <210> 187 <211> 4217 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1873) .. (3714) <400> 187 aaatttagaa gttagtaaat catttcactt aactggagtt tatcagatta cagagcctgg 60 ggatattaga agacaccaaa atagcattga tacaatcaac atctgtattt aagtcagcat 120 cctaatttca cttgctatgg aaaaaatgtg taacaacata taaatattgg atgaaaatgt 180 tggaatgctt aaaaacaatc tggagaattt ctagtgttta cagggaactg caagtctaca 240 ctgtaatatc tttacagtgt aataagaaat tgaagtgtct tgtgactatg ctacactgaa 300 acatgtttaa tttctctact gtaaatggcc ttttcattgt aaagtacagg tttacttctt 360 tagaatacta attttaatat gtcatattcg cactttcagg tttttggtta cattttaagt 420 ttggtggaaa acatttacat tgaaaagtag gataatttga tggaggaatt ttgttcttta 480 tcttgaggtt tgagggcctt cagcccactg tgtacaatat agaggaacaa aactgagtct 540 ctgaaaggat gtgaccaggc tgtgtgatgc ctgtggctta ctgggcaaat tcataaacgt 600 gaaatcaaaa gaagcatgga gggatggttt ccttctcttt aaaagaggca aaaattattt 660 gcttctgcac caaactttta ttgtaaggat cgaataagat attgacacca tgttccaaaa 720 attatactca gttaaaaaaa ctctaactga tattattcca gttttttgct attgtctgct 780 catcaaaatt attataattt atgtacacgt atttaaggaa agaaaaaaat gcttctcatc 840 aagatttgaa ttatacactt aaactacttc tttattttca aagtgctatt tgcttatttt 900 ggagctcgga gcaaatgata agtttctctt aattactggt cactcatatt acacaacaga 960 cactgtgagt ggcttcctaa tgactcaaag cataatgaac gctgtaggga cagaaaacct 1020 tctaggcttc agaagtaata tatcagatat gacagagacc ctttaatgag agtcataaat 1080 tttaactgtc taaaccagaa acaaacgttt tagcacttcc tctgtggatg aacccaagtc 1140 cagatcattc attgagttct gtggtctgca atgacaactg tgagaaatta acaaggaagt 1200 ggagcccttt cctttaataa taccaaatga ttaaaaagac ctaaaaaaaa tcaattgact 1260 aatcaatagt gtgtaactgc ttgaagcatt ttccccatgc taatcaacca ttaagttgtt 1320 taaactaaat acctccattt tctccaatta ctgaaccgat ttacaagaca tggtcaaggg 1380 tgtcagagtc tactggagcc agattccaga gctttcgtta ttggaggaga cagaaaataa 1440 tttttaagtg atcctctctc actacacagt ctaaagactc ttaaaaggga agatgtgata 1500 gaagatattc tgccagttcc agacattggt gaattaatgt gttactctca agttctaaac 1560 atgtatattt gtttgagaat atgggtagga agttatttga atttaggagt aatagaggtc 1620 aaaataacta aagaaaacat ctatacaata tatacaggca ggcctttaaa tttgtttttc 1680 aatttcagcc atgatga gca gcatgtagca aacaagaccc caaattcaaa acaacaaaaa 1740 gtattctaac atgtgaagtg acatattatt acctacctgt atattgccag caactctagt 1800 atgaaaacca cttgtaaact tttaagttaa atgacactgt gggggaagaa caacactaaa 1860 aaataacttt aa aca agg ggg aaa aac ttt ttt att gat atg ttt tac ttt 1911 Thr Arg Gly Lys Asn Phe Phe Ile Asp Met Phe Tyr Phe 1 5 10 gct ggc aga cca gag caa agg ttt tgt gaa cat tta aaa gat gaa aaa 1959 Ala Gly Arg Pro Glu Gln Arg Phe Cys Glu His Leu Lys Asp Glu Lys 15 20 25 ggt gaa gaa tcc cag aag cgg ttt atc ttg ag cga gat aac tct agt 2007 Gly Glu Glu Ser Gln Lys Arg Phe Ile Leu Lys Arg Asp Asn Ser Ser 30 35 40 45 att gat aaa gaa gac aat cag caa aac aga atg cat cca ttt aga gat 2055 Ile Asp Lys Glu Asp Asn Gln Gln Asn Arg Met His Pro Phe Arg Asp 50 55 60 gac aga cga agt aaa tca att gaa gag aga gaa gag gaa tat cag aga 2103 Asp Arg Arg Ser Lys Ser Ile Glu Glu Arg Glu Glu Glu Tyr Gln Arg 65 70 75 gtg agg gag aga ata ttt gca cac gat tca gtt tgc tcc cag gaa agc 2151 Val Arg Glu Arg Ile Phe Ala His As p Ser Val Cys Ser Gln Glu Ser 80 85 90 ctt ttt gtg gaa aac agg ggc aac aga gat ggc tca ggg aga aca tct 2199 Leu Phe Val Glu Asn Arg Gly Asn Arg Asp Gly Ser Gly Arg Thr Ser 95 100 105 ggg agt cga cag agc agc tca gaa aat gaa ctc aag tgg tct gac cac 2247 Gly Ser Arg Gln Ser Ser Ser Glu Asn Glu Leu Lys Trp Ser Asp His 110 115 120 125 caa agg gcc tgg agc agc aca gac tcc gac agt tcc aac cgc ata cta 2295 Gln Arg Ala Trp Ser Ser Thr Asp Ser Asp Ser Ser Asn Arg Asn Leu 130 135 140 aag ccc gcc atg acc aag acg gcg agt ttt ggg ggc atc acg gtg ctg 2343 Lys Pro Ala Met Thr Lys Thr Ala Ser Phe Gly Gly Ile Thr Val Leu 145 150 155 acc agg ggt gac agc act tcc agt act agg agt acc ggg aag ctg tcc 2391 Thr Arg Gly Asp Ser Thr Ser Ser Thr Arg Ser Thr Gly Lys Leu Ser 160 165 170 aaa gca ggt tcc gag tct tcc agc agt gca ggc tcc tca gga tcg ctg 2439 Lys Ala Gly Ser Glu Ser Ser Ser Ser Ala Gly Ser Ser Gly Ser Leu 175 180 185 tcc cgc acc cat cca cct ctc cag agc aca ccc cta gtc tca ggt gtg 2487 Ser Arg Thr His Pr o Pro Leu Gln Ser Thr Pro Leu Val Ser Gly Val 190 195 200 205 gca gct ggc tct cca ggc tgt gtg cct tat cca gag aat gga ata ggg 2535 Ala Ala Gly Ser Pro Gly Cys Val Pro Tyr Pro Glu Asn Gly Ile Gly 210 215 220 ggc cag gtt gct ccc agc agc acc agc tac atc ctc ctt cca ctt gaa 2583 Gly Gln Val Ala Pro Ser Ser Thr Ser Tyr Ile Leu Leu Pro Leu Glu 225 230 235 gct gca aca ggc atc ccg cct gga acc cc c aat cca cac aca 2631 Ala Ala Thr Gly Ile Pro Pro Gly Ser Ile Leu Leu Asn Pro His Thr 240 245 250 ggc cag ccc ttt gtg aat ccc gat gga act cct gca ata tac aac cca 2679 Gly Gln Pro Phe Val Asn Pro Asp Gly Thr Pro Ala Ile Tyr Asn Pro 255 260 265 ccc acc agt cag cag ccc ctg cga agc gcc atg gtg ggg cag tcc caa 2727 Pro Thr Ser Gln Gln Pro Leu Arg Ser Ala Met Val Gly Gln Ser Gln 270 275 280 285 cag cag cca cca cag cag cag ccc tcc ccg cag ccc caa cag cag gtc 2775 Gln Gln Pro Pro Gln Gln Gln Pro Ser Pro Gln Pro Gln Gln Gln Val 290 295 300 cag cca ccg cag cca cag atg gca ggc cct ctg gtc act cag tct gtc 2823 Gln Pro Pro Gln Pro Gln Met Ala Gly Pro Leu Val Thr Gln Ser Val 305 310 315 cag ggg ctg cag gct tcc tcc cag tca gtg caa tat cca gca gtc tct 2871 Gln Gly Leu Gln Ala Ser Ser Gln Ser Val Gln Tyr Pro Ala Val Ser 320 325 330 ttt cct ccc cag cac ctc cta cct gtg tct cca acg cag cac ttt ccc 2919 Phe Pro Pro Gln His Leu Leu Pro Val Ser Pro Thr Gln His Phe Pro 335 340 345 atg aga gat gat gtg gca aca cag ttt ggc cag atg acc ctg agc cgg 2967 Met Arg Asp Asp Val Ala Thr Gln Phe Gly Gln Met Thr Leu Ser Arg 350 355 360 365 cag tcc tcg ggg gag act cct gaa ccc cca tca ggt cct gtc tac cca 3015 Gln Ser Ser Gly Glu Thr Pro Glu Pro Pro Ser Gly Pro Val Tyr Pro 370 375 380 tcc tcc ctt atg cca cag ccg gcc cag cag ccc agc tat gta atc gcc 3063 Ser Ser Leu Met Pro Gln Pro Ala Gln Gln Pro Ser Tyr Val Ile Ala 385 390 395 tct aca ggc cag cag ctt cct aca gga gga ttc tca ggc tct ggc cct 3111 Ser Thr Gly Gln Gln Leu Pro Thr Gly Gly Phe Ser Gly Ser Gly Pro 400 405 410 ccc atc tcc cag cag gtc ctc cag ccc cct ccc tca cca cag gga ttt 3159 Pro Ile Ser Gln Gln Val Leu Gln Pro Pro Pro Ser Pro Gln Gly Phe 415 420 425 gtg caa cag cct ccg cct gca cag atg cct gta tat tat tac cca tct 3207 Val Gln Gln Pro Pro Pro Ala Gln Met Pro Val Tyr Tyr Tyr Pro Ser 430 435 440 445 ggt cag tac cct acc tca acc acg caa cag tac cgg ccc atg gcc ccg 3255 Gly Gln Tyr Pro Thr Ser Thr Thr Gln Gln Tyr Arg Pro Met Ala Pro 450 455 460 gtt cag tac aac gct cag agg agt caa cag atg cca cag gca gca cag 3303 Val Gln Tyr Asn Ala Gln Arg Ser Gln Gln Met Pro Gln Ala Ala Gln 465 470 475 caa gca ggt tac cag cca gtc ttg tct ggt caa cag ggac tca 3351 Gln Ala Gly Tyr Gln Pro Val Leu Ser Gly Gln Gln Gly Phe Gln Gly 480 485 490 cta ata gga gtg cag cag cca cct cag agt cag aac gtg ata aat aac 3399 Leu Ile Gly Val Gln Gln Pro Pro Gln Ser Gln Asn Val Ile Asn Asn 495 500 505 caa caa gga act ccg gtg caa agc gtg atg gtt tcc tac cca aca atg 3447 Gln Gln Gly Thr Pro Val Gln Ser Val Met Val Ser Tyr Pro Thr Met 510 515 520 525 tct tct tat cag gtg c ca atg acc cag ggt tct caa gga ctg ccc cag 3495 Ser Ser Tyr Gln Val Pro Met Thr Gln Gly Ser Gln Gly Leu Pro Gln 530 535 540 cag tca tac caa cag cca atc atg cta cct aac cag gca ggt caa ggg 3543 Gln Ser Tyr Gln Gln Pro Ile Met Leu Pro Asn Gln Ala Gly Gln Gly 545 550 555 tca ctc cca gcc act gga atg cct gtt tac tgt aat gtc aca ccg ccc 3591 Ser Leu Pro Ala Thr Gly Met Pro Val Tyr Cys Asn Val Thr Pro Pro 560 565 570 acc cct cag aac aac ctt agg ctg att ggc cca cac tgc ccc tcc agc 3639 Thr Pro Gln Asn Asn Leu Arg Leu Ile Gly Pro His Cys Pro Ser Ser 575 580 585 act gtc cca gtg atg tca gct agc tgc aga aac tgt gca agt atg 3687 Thr Val Pro Val Met Ser Ala Ser Cys Arg Thr Asn Cys Ala Ser Met 590 595 600 605 agc aat gct ggt tgg cag gtc aaa ttc tgagagctct ggctgtggta 3734 Ser Asn Ala Gly Trp Gln Val Lys Phect tt cattt atggcctttg atggaagagg aacaaggtgg gaaaactggc 3794 tgaggactta agtattcact caacactcaa atgattgctg ctggtattct gtaaaaaata 3854 aacaaagact aatatacacg ttagctggtt aatggtgcat att tctgtca tgtctgctag 3914 gtatgccttt atagcttagc tagtgacatg aattcatcaa ggtaagattt tctcctacca 3974 ctgaatacca ctgtgtagat tataatatcc ctaatttgga ttagttttgt actttgtgtt 4034 gagtttgtga tgctaaaagt atttaaaaat tatatactaa atcacattgt accaaagctg 4094 taatggaaaa gcaaagaaga attgatgaat tgaaggaata atttatatac attatagagt 4154 tttctttttt aatggatata tactgtattg tagtgtttaa tcaaaataaa actatttgac 4214 ctt 4217 <210> 188 <211> 4483 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2576) <400> 188 tg agg cgc tgc cgg tgg gcc gcc ctg gcc ctg ggg ctg ctg cgc ctc 47 Arg Arg Cys Arg Trp Ala Ala Leu Ala Leu Gly Leu Leu Arg Leu 1 5 10 15 tgc ttg gct cag gcc ccc gcc ttc ttc gac aac ggg gtc 95 Cys Leu Ala Gln Ala Asn Phe Ala Pro His Phe Phe Asp Asn Gly Val 20 25 30 ggc agc acc aac gga aac atg gct ctg ttc agc ctc cca gag gac acc 143 Gly Ser Thr Asn Gly Asn Mn Ala Leu Phe Ser Leu Pro Glu Asp Thr 35 40 45 cct gta ggc tct cac gta tac acc ctg aat ggg aca gac cct gag gga 191 Pro Val Gly Ser His Val Tyr Thr Leu Asn Gly Thr Asp Pro Glu Gly 50 55 60 gac ccc atc tcc tac cac atc agc ttt gac ccc agc act aga agc gtc 239 Asp Pro Ile Ser Tyr His Ile Ser Phe Asp Pro Ser Thr Arg Ser Val 65 70 75 ttt tct gtt gac ccc act ttt gga aac atc acc ctg gtt gaa gag ctg 287 Phe Ser Val Asp Pro Thr Phe Gly Asn Ile Thr Leu Val Glu Glu Leu 80 85 90 95 gac aga gag agg gaa gat gag att gaa gcc atc atc agc att tct gat 335 Asp Arg Glu Arg Glu Asp Glu Ile Glu Ala Ile Ile Ser Ile Ser Asp 100 105 110 ggc ctg aat ctg gtg gcc gaa aaa gtc gtg atc ctg gtg acc gat gcc 383 Gly Leu Asn Leu Val Ala Glu Lys Val Val Ile Leu Val Thr Asp Ala 115 120 125 aat gat gag gcg ccc agg ttc atc cag gag cct tat gtt gtt 431 Asn Asp Glu Ala Pro Arg Phe Ile Gln Glu Pro Tyr Val Ala Leu Val 130 135 140 ccc gag gac ata cct gct ggg agc atc atc ttt aag gtc cat gcg gtg 479 Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile Phe Lys Val His Ala Val 145 150 155 gac agg gac aca ggc tct gga ggg agt gtc acc tac ttc ctg cag aac 527 Asp Arg Asp Thr Gly Ser Gly Gly Ser Val Thr Tyr Phe Leu Gln Asn 160 165 170 175 ctg cac tcc cca ttt gcc gtg gac cgc cac agc ggt gtg ctg cgc ctc 575 Leu His Ser Pro Phe Ala Val Asp Arg His Ser Gly Val Leu Arg Leu 180 185 190 cag gct ggg gcc act ctg gac tac gag agg tcc cgg acc cac tac atc 623 Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg Ser Arg Thr His Tyr Ile 195 200 205 acc gtg gtc gcc aag gat ggc ggt ggg agg ctt cat ggg gct gat gtg 671 Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala Asp Val 210 215 220 gtg ttc tca gcc acc acc acg gtc acg gtc aat gtg gag gat gtt cag 719 Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp Val Gln 225 230 235 gac atg gcc cct gtc ttc gtg ggc aca ccc tac tat ggc tat gtg tac 767 Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr Val Tyr 240 245 250 255 gag gac acc ctt ccg ggc tcg gag gta ctg aag gtg gtc gcc atg gat 815 Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala Met Asp 260 265 270 gga gac cgg ggc aaa ccc aat cga att ctc tac agc ctt gta aat ggg 863 Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly 275 280 280 aac gat gga gcc ttt gaa att aat gag aca tct gga gcc atc tcc atc 911 Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile 290 295 300 act cag agc ccg gcc cag ctc cag aga gag gtg tat gag ctg cat g Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val 305 310 315 cag gtg act gaa atg agc cct gcg ggg agc cca gct gcc cag gcc acc 1007 Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala G ln Ala Thr 320 325 330 335 gtc cca gtc acc atc agg att gtg gac ctc aac aac cac ccg cca aca 1055 Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr 340 345 350 ttc tat gga gag agc gga ccc caa aac agg ttt gag ctg tcc atg aat 1103 Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn 355 360 365 gag cac cca ccc cag gga gag atc ctg cgg ggc ctc aag atc acc gtc 1151 Glu His Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile Thr Val 370 375 380 aat gac tcc gac cag gga gcc aat gcc aaa ttc aac ttg cag ctg gtg 1199 Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu G390 Leu Val 395 gga ccc agg ggc atc ttc cga gtg gtt cca cag aca gtc ctg aat gaa 1247 Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu Asn Glu 400 405 410 415 gcc caa gtc aca atc att gtg gag aac tca att gac ttt gaa 1295 Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp Phe Glu 420 425 430 aag tcc aaa gta tta acc ttc aag ctc ctg gct gtt gaa gtg aac acc 1343 Lys Ser Lys Val Leu Thr Phe L ys Leu Leu Ala Val Glu Val Asn Thr 435 440 445 cca gag aag ttc agt tcc aca gcg gat gtt gtg atc cag ctc ctg gac 1391 Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile Gln Leu Leu Asp 450 455 460 acc aat gac aat gtc ccc aag ttc gac tcc ctc tac tac gtt gcc agg 1439 Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg 465 470 475 att cct gag aac gcc cca ggg ggc tcc agc gtg ggt gct ggt 1487 Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val Ala Val Thr Ala 480 485 490 495 gtg gat cca gat aca gga ccc tgg ggc gaa gtg aaa tat tcc acc tat 1535 Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr 500 505 510 ggg act ggg gca gac ctc ttc ctg atc cac cca tcc act ggg ctt atc 1583 Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser Thr Gly Leu Ile 515 520 525 tac acc cag ccc tgg gct agc ctg gac gct gag gcc act gcc agg tac 1631 Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr 530 535 540 aac ttc tat gtg aag gca gag gac atg gag ggc aag tac agc gta gct 1679 Asn Phe yr Val Lys Ala Glu Asp Met Glu Gly Lys Tyr Ser Val Ala 545 550 555 gag gtg ttt atc aca ctg ctg gat gtc aat gac cac ccc cct cag ttt 1727 Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His Pro Pro Gln Phe 560 565 570 575 gga aag agc gtt cag aag aag acg atg gtg cta ggg acc cca gtg aaa 1775 Gly Lys Ser Val Gln Lys Lys Thr Met Val Leu Gly Thr Pro Val Lys 580 585 590 att gag gcc ata gac gag gat gca gag gaa ccc aac aac ctg gtg gac 1823 Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro Asn Asn Leu Val Asp 595 600 605 tat tcc atc acc cat gca gag ccc gcc aac gtg ttc gac atc aat tcc 1871 Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser 610 615 620 620 cac acg ggg gag atc tgg ctc aag aat tcc atc cgc tcc ctg gat gcc 1919 His Thr Gly Glu Glu Ile Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala 625 630 630 ctc aac atc aca cct gga agg gac tgc cta tgg tcc cta gag gtg 1967 Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val 640 645 650 650 cag gcc aag gac cgg ggc tcc cca tcc ttc agc acc aca gcc tta ctc 2015 Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu 660 665 670 aag att gac atc aca gat gct gag acc ctc tcc cgg agc ccc atg gct 2063 Lys Ile Asp Ile Thr Asp Ala Glu Thr Leu Ser Arg Ser Pro Met Ala 675 680 685 gcc ttc ctg ata cag acc aag gac aac ccc atg aag gcc gtg ggt gtg 2111 Ala Phe Leu Ile Gln Thr Lys Asp Asn Pro Met Lys Ala Val Gly Val 690 695 700 ctg gcc ggc acc atg gcc acc gtc gtg gcc atc act gtc ctc atc tcc 2159 Leu Ala Gly Thr Met Ala Thr Val Val Ala Ile Thr Val Leu Ile Ser 705 710 715 acc gcc acc ttc tgg cgc aac aag aag tct aac aag gtc ctg cca atg 2207 Thr Ala Thr Phe Trp Arg Asn Lys Lys Ser Asn Lys Val Leu Pro Met 720 725 730 735 cgg cgg gtg ctc cgc aag cgg ccc agc cct gcg ccc cgc acc atc cgc 2255 Arg Arg Val Leu Arg Lys Arg Pro Ser Pro Ala Pro Arg Thr Ile Arg 740 745 750 att gag tgg ctc aag tcc aag agc acc aaa gcc gct acc aag ttc atg 2303 Ile Glu Trp Leu Lys Ser Lys Ser Thr Lys Ala Ala Thr Lys Phe Met 755 760 765 ctc aaa gag aaa cct ccc aat gag aac tgt aac aac aac agc cca gaa 2351 Leu Lys Glu Lys Pro Pro Asn Glu Asn Cys Asn Asn Asn Ser Pro Glu 770 775 780 agc tct ctg ctc ccg aga gct ccg gct ctc cct cca cca ccc agc gtg Leu Serg Ser Leu Ala Pro Ala Leu Pro Pro Pro Pro Ser Val 785 790 795 gcg ccc agc act ggc gca gcc cag tgg acc gtg cct acc gtc tct ggc 2447 Ala Pro Ser Thr Gly Ala Ala Gln Trp Thr Val Pro Thr Val Ser Gly 800 805 810 815 815 tct ctc act ccg cag ccg acc caa ccc ccg cca aaa ccc aaa act atg 2495 Ser Leu Thr Pro Gln Pro Thr Gln Pro Pro Pro Lys Pro Lys Thr Met 820 825 830 gga agc ccc gtc cag tca act ctg atc tct gag ctc aag caa aag ttt 2543 Gly Ser Pro Val Gln Ser Thr Leu Ile Ser Glu Leu Lys Gln Lys Phe 835 840 845 gag aag aag agt gtg cac aac aag gct tac ttc tagtgtgtgc cctatgaccc 2596 Glu Lys Lys Ser Val His Asn Lys Ala Tyr Phe ct 850 ctccgcccct gacccccacc accctgctgc tcggactatg ctccccttcc 2656 tctgctcctt aaggtcactg acccctgttt tgcacaatgg tataatcccc actgtcctca 2716 tctctaccgc caccttctgg cgcaacaaga agttgcg ctc tgacagggct ctagtcaggg 2776 ccttgggcaa gacattgggc tctaggatgc aattggcaaa tacgtccccg ttactcaaat 2836 ccttggcact actacaatgc cctccattct tcagggctga gaattgacga gaagccagct 2896 cacccatccc agacctcaca gtccctcagg ttctactggg atctcatcat catccttagt 2956 caagcagcag ggccctggcc acgtggagca acactgacta gaatctggat cctgacgcct 3016 gcagctgaga gcaggagcag gaaaaggagg ctcagcactg tctcaggctg gaggtcagcg 3076 aacctcgtgg gctgtaggaa agcaaatgta ggtaagggga gagcaaggat gcacagaaaa 3136 cacactgact gtgggactgt gccaggatgc atttggaaag atagagcatt ctgtctgggc 3196 agagactgtg gaccctggta tgcccacgtg ggacagagga cacagaggtg gaagattgat 3256 cttgccaaga gtgagggcag atgtctccag ccaggactgc cctgagccgc aaaatgtcaa 3316 agctggagct atagaggtag ccctaaaggc aactagaaga gcatcagggc tgctctctga 3376 ggagctgccc caccagccat ccttgaagag acaattcagg gcagttgatg aatatcaggg 3436 ctgagatgtg gggagacttc cgtttttatc cagctctttt gctcacatca cgtaaccttg 3496 ggaaagctgt ttaaagtcgc tgatcatcct cttcctcatc tgtaaatgaa gaaagtaggc 3556 cctgtctacc tcacatgcag gtctagggtg aggattgaag a aaatagtgg tgatgagggc 3616 tttaaccaag tgcaaagcgg catgaatgca aagtattttt ctgcagccca gttctgtggg 3676 tgcagctctt ccagaaagta ttaggagcct cacatctact ctgccaagcg ccccagcagg 3736 cactgtgctg ggcttagggg ctaccactgg atgatggcat tgccgtgact cacacacctc 3796 tacttctgtt cttccctcac tccatccccg ctaccgtcct ggccagctac cgtcagagag 3856 aaccagagct ccaagtcttt aatttgccaa gatgaagaaa atgagttctc aaggagggaa 3916 tgctttgctt gaggccacac agcaggttgg tagcaaagat cttgtctagc cagggcagcc 3976 cttatcagct tgtgacaacc ttccccagga cagaagtcat acaaggcctc tggggttaat 4036 acaaataggt tgtgccctgc tttaaggaac ctgctatcag gaaatctaca tgtgtgcaca 4096 gagagagaaa agtagaacag ttctttgcat ttggctctac ttactaacaa cccctctaga 4156 atacattggt gatttcattt aaagagattg tatgcatttg tggctttcct gatttctgag 4216 tctgtgtttg gaggtgttac tgagatgtgc cagtgtgcag aatccttgct ggggtttcta 4276 cagtccccaa cgtgaacagt attaagcaag aggtggactc gagcaatcca ggagcccaga 4336 ctgagcaaat aagtactttc cagcctgtgt ttcaggagag gactgtgctg gatcatgctt 4396 gccctccaca gggaatacag catccttaca gcttgcatgc aatcaac ctc ttttgtaaat 4456 ggaaaataaa gtctgttacc caaaggc 4483 <210> 189 <211> 4182 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (130) .. (954) <400> 189 gccggaagtg catcggcccc gggtctgtcc gggcgttgcg ggattggggc ctgggaacgc 60 tcggcccccg gcagccgaga agcccgtgac tgggctgagc agcaccatcc cagccctggg 120 gcctgctga ctg cga acc cgg agc gtt gct atc ctc cac cgg act gtc agg 171 Leu Arg Thr Arg Ser Val Ala Ile Leu His Arg Thr Val Arg 1 5 10 ctc tgc gcg ccc cgc gga ggt cgg cgg cga cca gca gcg act gcg gag 219 Leu Cys Ala Pro Arg Gly Gly Arg Arg Arg Pro Ala Ala Thr Ala Glu 15 20 25 30 cga cgg cgg gcg gcc ccg ggc atg tac gcc ccc ggc gca ggg ctg 267 Arg Arg Arg Ala Ala Pro Gly Met Tyr Ala Pro Gly Gly Ala Gly Leu 35 40 45 ccc ggc ggg cgc cgg cgg agg agc ccg gga ggc agc gct ctg ccc aag 315 Pro Gly Gly Arg Arg Arg Arg Gly Gly Ser Ala Leu Pro Lys 50 55 60 cag ccg gag cgt agc ctg gcc tcg gcc ctg cct ggc gcc ctg tct atc 363 Gln Pro Glu Arg Ser Leu Ala Ser Ala Leu Pro Gly Ala Leu Ser Ile 65 70 75 acg gcg ctg tg act gcc ctc gcc gag ccc gcc tgg ttg cac atc cac 411 Thr Ala Leu Cys Thr Ala Leu Ala Glu Pro Ala Trp Leu His Ile His 80 85 90 gga ggc ac c tgt tcg cgc cag gag ctg ggg gtc tcc gac gtg ttg ggc 459 Gly Gly Thr Cys Ser Arg Gln Glu Leu Gly Val Ser Asp Val Leu Gly 95 100 105 110 tat gtg cac ccg gac ctg ctg aaa gat ttc tgcc atg aca 507 Tyr Val His Pro Asp Leu Leu Lys Asp Phe Cys Met Asn Pro Gln Thr 115 120 125 gtg ctg ctc ctg cgg gtc atc gcc gcc ttc tgt ttc ctg ggc atc ctg 555 Val Leu Leu Leu Arg Val Ile Ala Ahe Phe Cys Leu Gly Ile Leu 130 135 140 tgt agt ctc tcc gct ttc ctt ctg gat gtc ttt ggg ccg aag cat cct 603 Cys Ser Leu Ser Ala Phe Leu Leu Leu Asp Val Phe Gly Pro Lys His Pro 145 150 155 gct ctg aag atc act cgt cgc tat gcc ttc gcc cat atc cta acg gtt 651 Ala Leu Lys Ile Thr Arg Arg Tyr Ala Phe Ala His Ile Leu Thr Val 160 165 170 ctg cag tgt gcc acc gtc att ggc ttt tct tat tgg gct tct gaa ctc 699 Leu Gln Cys A Thr Val Ile Gly Phe Ser Tyr Trp Ala Ser Glu Leu 175 180 185 190 atc ttg gcc cag cag cag cag cat aag aag tac cat gga tcc cag gtc 747 Ile Leu Ala Gln Gln Gln Gln His Lys Lys Tyr His Gly Ser Gln Val 195 200 205 tat gtc acc ttc gcc gtt agc ttc tac ctg gtg gca gga gct ggt gga 795 Tyr Val Thr Phe Ala Val Ser Phe Tyr Leu Val Ala Gly Ala Gly Gly 210 215 220 gcc tca atc ctg gcc acg gca gcc aac ctc ccg tac ccc aca 843 Ala Ser Ile Leu Ala Thr Ala Ala Asn Leu Leu Arg His Tyr Pro Thr 225 230 235 gag gaa gag gag cag gcg ctg gag ctg ctc tca gag atg gaa gag aac 891 Glu Glu Glu Glu Glu Gln Ala Leu Glu Ser Glu Met Glu Glu Asn 240 245 250 gag ccc tac ccg gcg gaa tat gag gtc atc aac cag ttc cag cca ccc 939 Glu Pro Tyr Pro Ala Glu Tyr Glu Val Ile Asn Gln Phe Gln Pro Pro 255 260 265 270 cct gct tac aca ccc taatgccagc cctgggctct cttcctcggc agcccctccc 994 Pro Ala Tyr Thr Pro 275 tcaactctgc agctcctctc gcacccagag gagctccttt ccccagcagg cctcactggt 1054 aggatcctga ccatcttctc caaaccttcc ccaggagaga ctctgccttt agggtcatcc 1114 aagtatccct gctctcagaa ccggaggtcc actggttttc tataatgtac tctttccctc 1174 ctgccacatc ctgccccctt cacattcacg agtcattacc agccagggaa ggtcatccaa 1234 gtttcctcca gcatgggcga tatctttggg accgag actt tccttggaga gctgctgaga 1294 gcggacagtc ccaaaaacaa gtgtcaaagg gcccaaggga aaggggactg tgccctggag 1354 gctcacttca cagggatcag tgtttgctcc acagctgtag ctctgggctg acgcccccca 1414 gaccccttcc ttctcggagt gacccgcccc caggccacct gctccgggga gttctgtgca 1474 ctttactctt tggacttctc ctcacgtgtg ccctggtttt atggggagag ggaatcgctg 1534 ttgggaaggc agagcagttg caaccctctc tgcccttgct tcatgtggct ggagcccagg 1594 caaggagagc aggagccagc gtgagactga ggccccctgg tgcctatcaa ggaccagagt 1654 gaaggggact acatctccca gcccttcacc ttttaaatat gagtggtttt aaaaggaaaa 1714 aaatgaaacc aggcaacagc aacaatattc tgtttttaaa atagggacaa gactgttgtc 1774 actttttaga catgtatccc attccttttg gctctgcaat atttggggct gtagctcctt 1834 ccaagcccat ggtagtccct ccccgagtct ctcccagtag aatgcagcct cccttccctg 1894 gccccttccc tctcagtgac ggtgactccc tggggccttc tcgtggaacc cagaggggct 1954 gaggactgtg gcctggctgg cgggccagcg tggtgctcct caggactgca gcactgagat 2014 ggaacctggc ctcagtttag gaacaggggc cacaacaggg caggaaccca ccaccctcca 2074 cataggaata caaccagtgg ggccacatca tgtgaggcat cagacccaca ctgtcagccc 2134 agcaggccgg gctgtgtcct tcagacccag tgctgcccta gactctgact cgggactcca 2194 gcttgccacg tgccctctcc cctcttgaat gtactctggt cttgcagtgt gctgctggga 2254 ctttcttgct cagccatcac tctggtcacc ttgtttgctc tgggtctggc tgaattttct 2314 gccctgagat ctgggcataa agtggatgaa acttgaaaga ccttcagtgt agatccagat 2374 ggccaacctg tccttgttaa gttacttgct tcttgggaat cagtgtcccc tgctgagctg 2434 aaaaggaaat ggattccaat ctcttccaac ctttaaggtg atagatagtt tgagcaagac 2494 tggagaatgg acaacactat gaagctgtgg ctagaaaggg actgtcatgt cccatccttt 2554 ggccagattg actggggatg tccggacaga tgcctgcatg ggtggtgagg gccacatctg 2614 cacacgagcc agtggctgct tgcagttcac tgctgtgatg ccagagtgtg ttcaaaggtg 2674 actctcctgc tcttctggac tcttctctca ggcaagaaag gctgcaggct gcctgctatg 2734 tgagcacaaa gccaaggaac tgaactaagt ctttctgtta agtcctgagt ttgtcattgg 2794 caggtttact tgtggccagc tctctctgcc cttgggtgtc tgagcaggca gaccagaaga 2854 ccaggcactg gacctgcatg ccaaagggac tggtcatctc ctgaggacct gtaaatgacc 2914 ctgtggactg ttccgcacga tccggaaccc actttttatt cactc cccat gtctttggcc 2974 ttcctcttct ttctctttcc ctctgccatc ctgacactga tagtttgtca tataaattcc 3034 ccgggttgtg tttttttttc tagaaaaaaa ttaaaaggga aaacaaaacc aaaaaaacca 3094 gaaaccacga ataagaatgg aaatgacaat ggctgcctgt catttttctg tcacgatttt 3154 cctgatttgg tttgttccct ttgtctcaga gaagcaggag atgttgatga ggctgtattt 3214 ttttttcttt ttcttgtttt tgagacaaga gtctcgctct gtcacccggg ctggagtgta 3274 acgtggcatg atctcagctc actgcaacct ctgcctcctg ggttcaagcg attatcctgc 3334 ctcagcctcc tgagtagctg ggattacagg catgcgccac tatgcccaga taattttttt 3394 gtatttttag tagagacagg gtttcaccat gttggccagg ctggtctgga actcctaacc 3454 tcaggttatc cacccacctt ggcctcccaa agtgctggga ttataggcat gaaccaccgt 3514 gcctggccaa agatgtaatt taaaatagtt agaagggact tggcatgggc cagctccgtg 3574 catggcattt tcacccccag agcttcctaa tcctgttttc acacaggaag tttctaggtc 3634 tttctagaac agctagaaat agtagctgac tcccgcccaa ggcccaacct tcaaaccctg 3694 agctcttcag gctgcatcct ctggtgagct atagaggaga acgtggctcc taaactctag 3754 ccatcctgtg ggaggaaata gacttctttg ggctgtggct tgcagaacaa actacacttt 3814 ttttccctct attgtttaaa ttttatttaa taatttgtgt gtttttctgt ctttattttc 3874 tgtatttcac gtgttccttc actccctaga aactgcactt tctttgaaac cataggtaat 3934 gaatcttact aggagaggca tggggataga gacagttctg ggagtgtgac ctgtaagcct 3994 cctgtagggc agtgccaggc cttgattgcc cacgttctct ccgttccttc ttccttcata 4054 catttgatca cacagcctac acccagcccc gagtgtgcat cacggtaaaa gagctgaggg 4114 ctctcttcag ggagcagccc atttaggtct cttttgttgt tgttagggag aatacacatc 4174 tttcttgg 4182 <210> 190 <211> 3970 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1431) <400> 190 gtt ccc aaa aat gcc aag gaa aag gaa gta cca ctg gag gaa gaa atg 48 Val Pro Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met 1 5 10 15 cta ata caa tca gag aaa aaa aca caa tta tcg aag act gaa tct gtc 96 Leu Ile Gle Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser Val 20 25 30 aaa gag tca gag tct cta atg gaa ttt gcc cag cca gag ata caa cca 144 Lys Glu Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro 35 40 45 caa gag ttt ctt aac aga cgc tat atg aca gaa gta gat tat tca aac 192 Gln Glu Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser Asn 50 55 60 aaa caa ggc gaa gag caa cct tgg gaa gca gat tat gct aga aaa cca 240 Lys Gln Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro 65 70 75 80 aat ctc cca aaa cgt tgg gat atg ctt act gaa cca gat g caa gag 288 Asn Leu Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln Glu 85 90 95 aag aaa cag gag tcc ttt aag tcc tgg gag gct tct ggt aag cac cag 336 Lys Lys Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln 100 105 11 0 gag gta tcc aag cct gca gtt tcc tta gaa cag agg aaa caa gac acc 384 Glu Val Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Thr 115 120 125 tca aaa ctc agg tct act ctg ccg gaa gag cag aag aag cag gag atc 432 Ser Lys Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile 130 135 140 tcc aaa tcc aag cca tct cct agc cag tgg aag caa gat aca cct aaa 480 Ser Lys Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro Lys 145 150 155 160 tcc aaa gca ggg tat gtt caa gag gaa caa aag aaa cag gag aca cca 528 Ser Lys Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr Pro 165 170 175 aag ctg tgg cca gtt cag ctg cag aaa gaa caa gat cca aag aag caa 576 Lys Leu Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln 180 185 190 act cca aag tct tgg aca cct tcc atg cag agc gaa cag aac acc acc 624 Thr Pro Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr Thr 195 200 205 aag tca tgg acc act ccc atg tgt gaa gaa cag gat tca aaa cag cca 672 Lys Ser Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln P ro 210 215 220 gag act cca aaa tcc tgg gaa aac aat gtt gag agt caa aaa cac tct 720 Glu Thr Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser 225 230 235 240 tta aca tca cag tca cag att tct cca aag tcc tgg gga gta gct aca 768 Leu Thr Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Thr 245 250 255 gca agc ctc ata cca aat gac cag ctg ctg ccc agg aag ttg aac aca 816 Ala Ser Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Thr 260 265 270 gaa ccc aaa gat gtg cct aag cct gtg cat cag cct gta ggt tct tcc 864 Glu Pro Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser 275 280 285 285 tct acc ctt ccg aag gat cca gta ttg agg aaa gaa aaa ctg cag gat 912 Ser Thr Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp 290 295 300 ctg atg act cag att caa gga act tgt aac ttt atg caa gag tct gtt 960 Leu Met Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser Val 305 310 315 320 ctt gac ttt gac aaa cct tca agt gca att cca acg tca caa ccg cct 1008 Leu Asp Phe Asp Lys Pro Ser Ser Ala Ile ProThr Ser Gln Pro Pro 325 330 335 tca gct act cca ggt agc ccc gta gca tct aaa gaa caa aat ctg tcc 1056 Ser Ala Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser 340 345 345 350 agt caa agt gat ttt ctt caa gag ccg tta cag gca gca att ccc cca 1104 Ser Gln Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Ala Ile Pro Pro 355 360 365 ggc aag caa ccg tct tca cta gct tct cca aat cct ccc atg gca aag 1152 Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala Lys 370 375 380 ggc tct gaa cag ggc ttc cag tca cct cca gca agt agt agt tca gta 1200 Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser Val 385 390 395 400 acc att aac aca gca ccc ttt caa gcc atg cag aca gta ttt aac gtt 1248 Thr Ile Asn Thr Ala Pro Phe Gln Ala Met Gln Thr Val Phe Asn Val 405 410 415 aat gca cct ctg cct cca cga aaa gaa caa gaa ata aaa gaa tcc cct 1296 Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser Pro 420 425 430 tat tca cct ggc tac aat caa agt ttt acc aca gca agt aca caa aca 1344 Tyr Ser Pro Gly Tyr Asn G ln Ser Phe Thr Thr Ala Ser Thr Gln Thr 435 440 445 cca ccc cag tgc caa ctg cca tct ata cat gta gaa caa act gtc cat 1392 Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Thr Val His 450 455 460 tct caa gag act gcc cct ggc aac cac cat tct act ttc tgattctgaa 1441 Ser Gln Glu Thr Ala Pro Gly Asn His His Ser Thr Phe 465 470 475 aatgactgct ctagcagcaa attatcatcc tgatggaact attcaagtaa gcaatggtag 1501 ccttgccttt tacccagcac agacgaatgt gtttcccaga cctactcagc catttgtcaa 1561 tagccgggga tctgttagag gatgtactcg tggtgggaga ttaataacca attcctatcg 1621 gtcccctggt ggttataaag gttttgatac ttatagagga ctggaagcaa gatacaccta 1681 aatccaaagc agggtatgtt caagaggaac aaaagaaaca ggagacacca aagctgtggc 1741 cagttcagct gcagaaagaa caagatccaa agaagcaaac tccaaagtct tggacacctt 1801 ccatgcagag cgaacagaac accaccaagt catggaccac tcccatgtgt gaagaacagg 1861 attcaaaaca gccagagact ccaaaatcct gggaaaacaa tgttgagagt caaaaacact 1921 ctttaacatc acagtcacag atttctccaa agtcctgggg agtagctaca gcaagcctca 1981 taccaaatga ccagctgctg cccaggaagt tgaacacaga acccaaagat gtgcctaagc 2041 ctgtgcatca gcctgtaggt tcttcctcta cccttccgaa ggatccagta ttgaggaaag 2101 aaaaactgca ggatctgatg actcagattc aaggaacttg taactttatg caagagtctg 2161 ttcttgactt tgacaaacct tcaagtgcaa ttccaacgtc acaaccgcct tcagctactc 2221 caggtagccc cgtagcatct aaagaacaaa atctgtccag tcaaagtgat tttcttcaag 2281 agccgttaca ggcagcaatt cccccaggca agcaaccgtc ttcactagct tctccaaatc 2341 ctcccatggc aaagggctct gaacagggct tccagtcacc tccagcaagt agtagttcag 2401 taaccattaa cacagcaccc tttcaagcca tgcagacagt atttaacgtt aatgcacctc 2461 tgcctccacg aaaagaacaa gaaataaaag aatcccctta ttcacctggc tacaatcaaa 2521 gttttaccac agcaagtaca caaacaccac cccagtgcca actgccatct atacatgtag 2581 aacaaactgt ccattctcaa gagactgccc ctggcaacca ccattctact ttctgattct 2641 gaaaatgact gctctagcag caaattatca tcctgatgga actattcaag taagcaatgg 2701 tagccttgcc ttttacccag cacagacgaa tgtgtttccc agacctactc agccatttgt 2761 caatagccgg ggatctgtta gaggatgtac tcgtggtggg agattaataa ccaattccta 2821 tcggtcccct ggtggttata aaggttttga tactt ataga ggactccctt caatttccaa 2881 tggaaattat agccagctgc agttccaagc tagagagtat tctggagcac cttattccca 2941 aagggataat ttccagcagt gttataagcg aggagggaca tctggtggtc cacgagcaaa 3001 ttcgagagct aactgcttca ttatgagaaa ctcactgttg ctaataaaac agcagggtgg 3061 agtgattctt ctcaggtgag cagcccagaa agagacaacg aaacctttaa cagtggtgac 3121 tctggacaag gagactcccg tagcatgacc cctgtggatg tgccagtgac aaatccagca 3181 gccaccatac tgccagtaca cgtctaccct ctgcctcagc agatgcgagt tgccttctca 3241 gcagccagaa cctctaatct ggcccctgga actttagacc aacctattgt gtttgatctt 3301 cttctgaaca acttaggaga aacttttgat cttcagcttg gtagatttaa ttgcccagtg 3361 aatggcactt acgttttcat ttttcacatg ctaaagctgg cagtgaatgt gccactgtat 3421 gtcaacctca tgaagaatga agaggtcttg gtatcagcct atgccaatga tggtgctcca 3481 gaccatgaaa ctgctagcaa tcatgcaatt cttcagctct tccagggaga ccagatatgg 3541 ttacgtctgc acaggggagc aatttatgga agtagctgga aatattctac gttttcaggc 3601 tatcttcttt atcaagattg aaagtcagta cagtattgac aataaaagga tggtgttcta 3661 attagtggga ttgaaggaaa agtagtcttt gccctcatga ctgattggtt taggaaaatg 3721 tttttgttcc tagagggagg aggtccttac ttttttgttt tccttcctga ggtgaaaaat 3781 caagctgaat gacaattagc actaatctgg cactttataa attgtgatgt agcctcgcta 3841 gtcaagctgt gaatgtatat tgtttgcact taatccttaa ctgtattaac gttcagctta 3901 ctaaactgac tgcctcaagt ccaggcaagt tacaatgcct tgttgtgcct caataaaaaa 3961 gttacatgc 3970 <210> 191 <211> 3948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1568) <400> 191 gg cca aag aag ttc gtc ccc ttt gtg agg ccc ggg atg gga gct ctg 47 Pro Lys Lys Phe Val Pro Phe Val Arg Pro Gly Met Gly Ala Leu 1 5 10 15 tct tcc cag gat tct ccc cat ttc caa gag aag agc aca gaa gag gga 95 Ser Ser Gln Asp Ser Pro His Phe Gln Glu Lys Ser Thr Glu Glu Gly 20 25 30 gaa gtg gct gct ctg cgc ctc acg gcc aga tcc cag gaa aca gtg aca 143 Glu Val Ala Ala Leu Arg Leu Thr Ala Arg Ser Gln Glu Thr Val Thr 35 40 45 ttc aag gat gtg gcc atg gac ttt aca cca gag gag tgg ggg aag ctg 191 Phe Lys Asp Val Ala Met Asp Phe Thr Pro Glu Glu Trp Gly Lys Leu 50 55 60 gat cct gca caa agg gat gtg atg ctg gag aac tat agg aac cta gtc 239 Asp Pro Ala Gln Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val 65 70 75 tca ctt tgg ctt cca gtt tcc aaa cct gag agc cac aat ttg gag 287 Ser Leu Trp Leu Pro Val Ser Lys Pro Glu Ser His Asn Leu Glu Asn 80 85 90 95 gga aaa gaa cca ttg aag ctt gag aga aaa gcc ccc aaa agc agc tat 335 Gly Lys Glu Pro Leu Lys Leu Glu Arg Lys Ala Pro Lys Ser Ser Tyr 100 105 110 tc a gac atg gag act aga cca cag agc aag gat tca act tca gtg caa 383 Ser Asp Met Glu Thr Arg Pro Gln Ser Lys Asp Ser Thr Ser Val Gln 115 120 125 gat ttt tcc aaa gca gaa tca tgc aaa gtt gca ata ata gac aga ctg 431 Asp Phe Ser Lys Ala Glu Ser Cys Lys Val Ala Ile Ile Asp Arg Leu 130 135 140 aca cgg aat agt gtc tat gac tct aac ttg gaa gca gcc ctt gaa tgt 479 Thr Arg Asn Ser Val Tyr Asp Ser Asn Leu Glu Ala Ala Leu Glu Cys 145 150 155 gaa aat tgg tta gag aat cag caa gga aat cag gag aga cat ttg aga 527 Glu Asn Trp Leu Glu Asn Gln Gln Gly Asn Gln Glu Arg His Leu Arg 160 165 170 175 gaa atg ttc act atg aat tca ctc tct gag gaa aca gac cat aag 575 Glu Met Phe Thr His Met Asn Ser Leu Ser Glu Glu Thr Asp His Lys 180 185 190 cat gat gta tac tgg aaa agc ttc aat cag aaa tct gtc ctt atc act 623 His Asp Val Tyr Trp Lys Ser Phe Asn Gln Lys Ser Val Leu Ile Thr 195 200 205 gaa gac aga gtt ccc aaa gga tct tat gcc ttc cat aca ctt gaa aaa 671 Glu Asp Arg Val Pro Lys Gly Ser Tyr Ala Phe His Thr Leu Glu Lys twenty one 0 215 220 agc ttg aaa caa aaa tca aac tta atg aaa aag cag aga act tat aaa 719 Ser Leu Lys Gln Lys Ser Asn Leu Met Lys Lys Gln Arg Thr Tyr Lys 225 230 235 gag aaa aaa cct cat aaa tgt aat gat tgt ggt gaa ctc ttc acc tac 767 Glu Lys Lys Pro His Lys Cys Asn Asp Cys Gly Glu Leu Phe Thr Tyr 240 245 250 255 cat tca gtg ctt att cga cac cag aga gtc cat act gga gag aaa ccc 815 His Ser Val Leu Ile Arg His Gln Arg Val His Thr Gly Glu Lys Pro 260 265 270 tat acc tgc aat gaa tgt ggg aaa tct ttt agc cac aga gct aat tta 863 Tyr Thr Cys Asn Glu Cys Gly Lys Ser Phe Ser His Arg Ala Asn Leu 275 280 285 285 act aaa cac cag aga act cat act aga att ctc ttt gaa tgc agt gaa 911 Thr Lys His Gln Arg Thr His Thr Arg Ile Leu Phe Glu Cys Ser Glu 290 295 300 tgc aag aaa acc ttc aca gaa agc tca tcc ctt gca aca cat cag aga 959 Cys Lys Lys Thr Phe Thr Glu Ser Ser Ser Leu Ala Thr His Gln Arg 305 310 315 att cac gtt gga gag aga cct tat gaa tgc aat gaa tgt ggg aaa ggt 1007 Ile His Val Gly Glu Arg Pro Tyr Glu Cys Asn Glu Cys G ly Lys Gly 320 325 330 335 ttt aat cga agt aca cat ctt gtg cag cat cag ttg att cat act gga 1055 Phe Asn Arg Ser Thr His Leu Val Gln His Gln Leu Ile His Thr Gly 340 345 350 gtg aag cct tat gaa tgt aat gaa tgt gat aaa gct ttt att cat tca 1103 Val Lys Pro Tyr Glu Cys Asn Glu Cys Asp Lys Ala Phe Ile His Ser 355 360 365 tca gca ctc att aaa cat caa aga act cat act gga gag aaa cct tat 1151 Ser Ala Leu Ile Lys His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 370 375 380 aaa tgt caa gaa tgt ggg aaa gcc ttt agc cat tgc tca tcc cta act 1199 Lys Cys Gln Glu Cys Gly Lys Ala Phe Ser His Cys Ser Ser Leu Thr 385 390 395 aag cat cag aga gtt cat act gga gaa aag cca tat gaa tgc agt gaa 1247 Lys His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu 400 405 410 415 tgt gga aaa act ttt agt cag agc aca cat ctt gtt caa cat cag aga 1295 Cys Gly Lys Thr Phe Ser Gln Ser Thr His Leu Val Gln His Gln Arg 420 425 430 att cac act gga gag aaa ccc tat gag tgt aat gaa tgt ggg aaa acc 1343 Ile His Thr Gly Glu Lys Pro Ty r Glu Cys Asn Glu Cys Gly Lys Thr 435 440 445 ttc agc cgg agc tcc aat ttt gct aaa cat caa aga att cat att gga 1391 Phe Ser Arg Ser Ser Asn Phe Ala Lys His Gln Arg Ile His Ile Gly 450 455 460 aag aaa ccg tac aaa tgt agc gag tgt gga aaa gcc ttc att cat tca 1439 Lys Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ile His Ser 465 470 475 tca gct ctt att caa cat cag aga act cat acc gga gag aaa ccc ttt 1487 Ser Ala Leu Ile Gln His Gln Arg Thr His Thr Gly Glu Lys Pro Phe 480 485 490 495 aga tgt aat gag tgt ggg aaa agc ttt aag tgc agt tca tct ctc atc 1535 Arg Cys Asn Glu Cys Gly Lys Ser Phe Lys Cys Ser Ser Ser Leu Ile 500 505 510 aga cat caa aga gtt cac act gaa gag caa ccc tgaaaaatta ctgaatgtga 1588 Arg His Gln Arg Val His Thr Glu Glu Gln Pro 515 520 agaaataaaa ctgattatat tcctggtccc tgaacgatcc tatagagaca tccagtccct 1648 gactccacct gcctccaggt gcccagaaca gcccatcgtg gggacttcac cctcagcaag 1708 tggacgccgt ttgtcctgcc agggcaggga caccgagctg gggcagcagt ggacttgggg 1768 catgagcagg ttgatgtcag aaaatacacc aataacctcg ggattgtgca tgagatggag 1828 ctgccccgcg tcagtgccct ggaggtgaag gtaagagcct gtgcctgctg cgtgggaggc 1888 tgcttcaggg actgggaatc gggtggtcgg taaggcagag ggggtggcct gtgggcctgt 1948 gtggtggtga gtgggccacg gctgtcactg ggaggggtgg cctttcctgc tggactctgt 2008 tcccatgagg acttgaccaa aacccaaacc aagaactgca gtcctggctc agagtccact 2068 gcctgtttga accaagaccc cagctgaagg ctggacctga ccaaaacttg gggcatttat 2128 ggcctgagga tggcatgtca tggcatcacc attccagact accagctcca gttccttcag 2188 agggtctcag cccctggggc ctgccctttc ctggcttctt caagttgggt cccttcaggg 2248 ccccaaagcc ctggacccag catccacggg ccactgtcag acgcctggca gctccgctaa 2308 ctccatcatg gctcatttga cagcaaagac gcaaggaaag taaacgtacc aacaagtggc 2368 aaaagatgct tgcagactgg acaaaatata ggagcaccaa gaaggtaaca tggggaggaa 2428 gtggcccgcg tgactgctct ctgcagagcc aggagacagg cacccatggt tgtgacctgg 2488 caccgtctgc ctctcagtgg gtgggtggta ccccatcctt gccataggac tgcaggcctg 2548 ttcgccagct ttgctctgcg gggtcgcccc atgtcctttc tcactggagt gttcttctgt 2608 ctgtagctgt ctcaaagagt atacaaagtc attccc ctgg cggtacgggg ccgggcgtgg 2668 tcacttttgc tagatattga cagaatcaag tcccagaacc caggcaaata taaggtcatg 2728 aaggagaagg gcaagaggtc ctccagaatc atccactgca tccagctaga tgtcagccac 2788 accctgcaga aacacatgat gttcatacaa agattcggag tcaagcagca ggaattatgt 2848 gacatcctcg tggcctattc tgcatataac cctgaggtgg gctaccacag ggacctgagc 2908 cgcatcactg ccatcctcct cctgtgtctg ccagaggaag atgttttctg ggcgcttacc 2968 cagttgctcg ctggtgagag gcactccctg tggtattcta cagcccaaat actgcctggc 3028 tcgagaagct cctatcgcac caggagcagg tgctgcacaa gtccttccca aagatcatga 3088 gacacctggg caaggaaggg ctgtgcattg agggttccat gctgacgagg ctcctccggt 3148 gtttccttga tgggaaatcc ttcgggctca ccctgagact gtgggatgtg ttcatcttgg 3208 agggcgcgcg ggtactgaca gccatggtgc atgcatcatt caaaatacac aggaagcacc 3268 tcatgaagct ttcctggagc actgtctggg agtttcagga gcgactctct cagagctggg 3328 ccctggagga caacgcggtc ctcaggaacc ttcaaacctc tatgaaggaa ctcacaaaaa 3388 aacactggga cctgccaccc ccagggagct tgctacaaaa tgcacattgc tataccatag 3448 cctggggctt gcaatccaag gctggcaagg attcctgcac gtcaagggcc tcaggtgact 3508 ttcatgcaca cccaagtcag aaggctctcc tgaatcctgg atgtcacctt cctgcccaaa 3568 aaaggaggaa cgagggtcaa ccagcagcag accagtcaca aaaagagatg aaatgtgagt 3628 gcatggcctt cctgacaccc agacaaaact ttgggcacaa agccaggctg cagctctggc 3688 cactgacttg gaccagggat gcccccatgc aggccggtgt gccctggctg ctcttgacac 3748 cctctggctc ctgacaccct ctcttcggct gcctgcgtta ggaagggaga acctgccagt 3808 tttcagaaga aaatgtagct ttattataac ataggaaaga ctgcaagtta ttacgggagg 3868 aggaggaggc ctgaaacagc tcctgaaaat gagagggaaa aggaaggtgt aaatatgttg 3928 gtaataaaat ctccaaccac 3948 <210> 192 <211> 4569 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1474) .. (3597) <400> 192 ccgcagccgc cgtccacagc gcccggctcc gcgcgagagc cctgccagag gagcggctcc 60 ggccgccgcg cctgaccctt gtccggggtc ttccgcacag tgggctgagg gccatgtcag 120 ttttctgcca cctacaggat agaccatgaa gctgaaggaa cttgagcggc cagctgtcca 180 ggcatggagc ccagccagcc aatacccttt gtatctggcc acaggaacat ctgcccaaca 240 gctagattcc tccttcagca caaatggcac attggaaata tttgaggttg atttcaggga 300 cccttctctg gacttgaaac acagaggagt cctttctgcc ttgagcaggg caacctcctg 360 gcttcagggg ccagcgattc tgaaatcttc atttgggatc tgaataactt gaatgtgcca 420 atgaccctgg gatccaagtc acagtatcat gagcctccag aggacatcaa ggcactgtct 480 tggaaccggc aagcccaaca cattctgtct tctgctcacc ccagtggcaa ggcagttgtg 540 tgggatctca ggaagaatga acctatcatc aaagtcagtg atcacagcaa caggatgcac 600 tgctcaggcc tggcctggca tcctgacata gccacccagt tagtgctgtg ctcagaggat 660 gatcgacttc ccgtgattca gctgtgggac ttgcgctttg cctcctcgcc cttgaaggtg 720 ctggagagcc acagcagggg gatcttgtca gtgtcatgga gccaggctga tgctgagctg 780 ctgctcacta gtgctaagga cagccagatc ttgtgccgga acctggggag cagtgaggtg 840 gtatataagc taccaacaca gagcagctgg tgctttgatg tgcagtggtg ccctcgggac 900 ccttcagtgt tctctgctgc ctccttcaac ggctggatca gtttgtacgc tgtgatggat 960 ctcctcttcc ttcagcaaag gccagcctct cccaccactg caggtgccag agcaagtggc 1020 acaagcatca ctgatacctc ccctgaaaaa accccccaaa tggattagaa gaccaacagg 1080 tgtttcattt gcttttggag ggaagctggt tacttttggc ctccccagca cccctgccca 1140 tctggtgcca cagccttgcc cccgcctagt cttcatcagt caagtcacca cagaatctga 1200 attcctgatg cgatcagctg agctgcagga ggccttggga tcaggaaatc tactgaatta 1260 ctgtcagaac aagagccagc aagctttact gcaaagtgaa aagatgctgt ggcagttcct 1320 gaaggtgacc ttagagcaag actccagaat gaaattccta aagcttttag gatacagtaa 1380 agatgagctt cagaagaagg tggccacatg gttgaagagt gacgtggggc taggtgagag 1440 tcctcagccc aagggaaatg acctcaacag tga cag aca aca ggc ctt ctg cag 1494 Gln Thr Thr Gly Leu Leu Gln 1 5 cca gat att gat gga ctc cta agc cag gct ctc ctg ctt ggg gaa ctg 1542 Pro Asp Ile Asp Gly Leu Leu Ser Gln Ala Leu Leu Leu Gly Glu Leu 10 15 20 ggt ccg gcc gtg gag ctg tgt ctg aag gag gag cgc ttt gct g at gcc 1590 Gly Pro Ala Val Glu Leu Cys Leu Lys Glu Glu Arg Phe Ala Asp Ala 25 30 35 att atc ctg gcc cag gct ggg ggt aca gat ctg ctg aag caa aca cag 1638 Ile Ile Leu Ala Gln Ala Gly Gly Thr Asp Leu Leu Lys Gln Thr Gln 40 45 50 55 gag cgc tac ttg gcc aag aag aaa acc aaa atc tcc tcg ctt cta gcc 1686 Glu Arg Tyr Leu Ala Lys Lys Lys Thr Lys Ile Ser Ser Leu Leu Ala 60 65 70 tgt gtt gtg caa aag aat tgg aag gat gtg gtg tgt acc tgt agc ctg 1734 Cys Val Val Gln Lys Asn Trp Lys Asp Val Val Cys Thr Cys Ser Leu 75 80 85 aag aac tgg aga gag gca ctg gct ttg cta ctg aca tac tca ggc aca 1782 Lysn Trp Arg Glu Ala Leu Ala Leu Leu Leu Thr Tyr Ser Gly Thr 90 95 100 gag aaa ttt ccc gag ctc tgt gac atg ctg gga act cgc atg gaa cag 1830 Glu Lys Phe Pro Glu Leu Cys Asp Met Leu Gly Thr Arg Met Glu Gln 105 110 115 gag ggc agc agg gca cta acc tcc gaa gcc aga ctc tgt tat gtg tgc 1878 Glu Gly Ser Arg Ala Leu Thr Ser Glu Ala Arg Leu Cys Tyr Val Cys 120 125 130 135 tca ggg agt gtg gag cgg ctg gtg gagg tgg gca a aa tgc cac cag 1926 Ser Gly Ser Val Glu Arg Leu Val Glu Cys Trp Ala Lys Cys His Gln 140 145 150 gct ttg tcc ccc atg gct ctg cag gac ctg atg gag aag gtg atg gtt 1974 Ala Leu Ser Pro Met Ala Leu Gln Asp Leu Met Glu Lys Val Met Val 155 160 165 ctt aac agg agc ttg gag caa ctg cgg ggt cct cat ggg gtg agc cca 2022 Leu Asn Arg Ser Leu Glu Gln Leu Arg Gly Pro His Gly Val Ser Pro 170 175 180 ggc cct gcc aca acc tac agg gtc act cag tat gcc aac ctc ctg gca 2070 Gly Pro Ala Thr Thr Tyr Arg Val Thr Gln Tyr Ala Asn Leu Leu Ala 185 190 195 gcc cag ggc agc ctg gcc act gcc atg agc ttt cta ccc agg gac tgt 2118 Ala Gln Gly Ser Leu Ala Thr Ala Met Ser Phe Leu Pro Arg Asp Cys 200 205 210 215 gct cag cca cca gtt cag cag cta aga gat cgg ctt ttt cat gct caa 2166 Ala Gln Pro Pro Val Gln Gln Leu Arg Asp Arg Leu Phe His Ala Gln 220 225 230 ggt tct gct gtc ttg ggc caa cag tct ccc cct ttc ccc ttc ccc cgg 2214 Gly Ser Ala Val Leu Gly Gln Gln Ser Pro Pro Phe Pro Phe Pro Arg 235 240 245 att gtt gtg gga gct acc ctc ca c tct aaa gag aca tca tct tac aga 2262 Ile Val Val Gly Ala Thr Leu His Ser Lys Glu Thr Ser Ser Tyr Arg 250 255 260 ttg gga tcc cag cct tct cac cag gtc cca act cca tct cca agg cca 2310 Leu Gly Ser Gln Pro Ser His Gln Val Pro Thr Pro Ser Pro Arg Pro 265 270 275 agg gtt ttc acc cct cag tca tca cca gcg atg ccc ttg gca cct tcc 2358 Arg Val Phe Thr Pro Gln Ser Ser Pro Ala Met Pro Leu Ala Pro Ser 280 285 290 295 cat cct agc cct tat cag ggt ccc agg aca cag aat ata agt gac tac 2406 His Pro Ser Pro Tyr Gln Gly Pro Arg Thr Gln Asn Ile Ser Asp Tyr 300 305 310 agg gca cct ggg ccc cag gcc atc cag cct ttg cct ttg agc cct ggg 2454 Arg Ala Pro Gly Pro Gln Ala Ile Gln Pro Leu Pro Leu Ser Pro Gly 315 320 325 gta agg cct gct tca tct cag cca cag cta tta gga ggg caa agg gtg 2502 Val Arg Pro Ala Ser Ser Gln Pro Gln Leu Leu Gly Gly Gln Arg Val 330 335 340 caa gtt cct aac ccg gtg gga ttc cct ggg aca tgg cct ctt cct ggt 2550 Gln Val Pro Asn Pro Val Gly Phe Pro Gly Thr Trp Pro Leu Pro Gly 345 350 355 tcc cct cta ccc atg gca tgc cca ggc atc atg cga cct ggc tct acc 2598 Ser Pro Leu Pro Met Ala Cys Pro Gly Ile Met Arg Pro Gly Ser Thr 360 365 370 375 tcc ctg cct gag act cct aga ctg ttc cct ctg ctt cct ctg agacca 2646 Ser Leu Pro Glu Thr Pro Arg Leu Phe Pro Leu Leu Pro Leu Arg Pro 380 385 390 cta ggt ccc ggc cgc atg gtc tcc cac acc cca gcc cct cct gca agc 2694 Leu Gly Pro Gly Arg Met Val Ser His Thr Pro Ala Pro Pro Ala Ser 395 400 405 ttc cct gtg cca tac ctt cca ggg gac cca ggt gcc cca tgc tct agt 2742 Phe Pro Val Pro Tyr Leu Pro Gly Asp Pro Gly Ala Pro Cys Ser Ser 410 415 420 gtc ctc cca acc act ggc atc ttg act cct cac cca ggt cag tct tcc 2790 Val Leu Pro Thr Thr Gly Ile Leu Thr Pro His Pro Gly Gln Ser Ser 425 430 435 ttc cat gga tcc ctc ttc tgg gtt att gcc tcc cct gct cct ctc act 2838 Phe His Gly Ser Leu Phe Trp Val Ile Ala Ser Pro Ala Pro Leu Thr 440 445 450 455 act ttg gga gtc ttt cct caa gtc aga ggg cta ggg ccc tgt tgg gtg 2886 Thr Leu Gly Val Phe Pro Gln Val Arg Gly Leu Gly Pro Cys Trp Val 460 465 470 gag ggt ggc tgg gag tgt aga tgg tct gca gag gga ggt atg gtg aac 2934 Glu Gly Gly Trp Glu Cys Arg Trp Ser Ala Glu Gly Gly Met Val Asn 475 480 485 tcc aac tca aag aat gct tcc agc ctt ca aaa aac ttc cag tgt 2982 Ser Asn Ser Lys Asn Ala Ser Ser Leu Gln Ile Lys Asn Phe Gln Cys 490 495 500 ttt tca cta tgc gcc gaa aaa cct cta tct ttt tat tct ata gga cct 3030 Phe Ser Leu Cys Ala Glu Lys Pro Leu Ser Phe Tyr Ser Ile Gly Pro 505 510 515 caa gat tcc tgg aaa gaa gcc cca gcc ccc agg gga aac ctc cag agg 3078 Gln Asp Ser Trp Lys Glu Ala Pro Ala Pro Arg Gly Asn Leu Gln Arg 520 525 530 530 aac aag ctg cca gag aca ttt atg ccc cca gca cca att act gct cca 3126 Asn Lys Leu Pro Glu Thr Phe Met Pro Pro Ala Pro Ile Thr Ala Pro 540 545 550 gtt atg agc ctc acc cct gag cta caa ggg att ctt ccc tca cag ccc 3174 Val Met Ser Leu Thr Pro Glu Leu Gln Gly Ile Leu Pro Ser Gln Pro 555 560 565 cct gtc tcc agt gtg agt cat gct ccc cca gga gtt cca gga gaa ctc 3222 Pro Val Ser Ser Val Ser His Ala Pro Pro Gly Val Pro Gly Glu Leu 570 575 580 agc ctg cag ctt cag cac ctg cca cct gag aag atg gaa agg aag gag 3270 Ser Leu Gln Leu Gln His Leu Pro Pro Glu Lys Met Glu Arg Lys Glu 585 590 595 595 ctg ccc cca gag cat ca tcc ttg aag agc agc ttt gag gcg ctt ctc 3318 Leu Pro Pro Glu His Gln Ser Leu Lys Ser Ser Phe Glu Ala Leu Leu 600 605 610 615 caa cgc tgc tcc ctg tct gca act gac tta aag aca aaa agg ag ctg 3366 Cys Ser Leu Ser Ala Thr Asp Leu Lys Thr Lys Arg Lys Leu 620 625 630 gaa gag gca gcc cag cgt ctg gag tat cta tat gag aag ctc tgt gag 3414 Glu Glu Ala Ala Gln Arg Leu Glu Tyr Leu Tyr Glu Lys Leu Cy 635 640 645 ggg aca ctc tca cct cat gtc gtg gct ggg ctg cat gag gtt gcc cga 3462 Gly Thr Leu Ser Pro His Val Val Ala Gly Leu His Glu Val Ala Arg 650 655 660 tgt gtg gat gca gga agc ttt gag cag ggc ctt gca gtg cat gcc cag 3510 Cys Val Asp Ala Gly Ser Phe Glu Gln Gly Leu Ala Val His Ala Gln 665 670 675 gtg gcg ggc tgt agc agc ttc agc gag gtg tcc agc ttc atg cct atc 3558 Val Ala Gly Cys he Ser Glu Val Ser Ser Phe Met Pro Ile 680 685 690 695 ctg aag tct gtc ctc atc atc gct cat aag ctg ctg gtc taaaccaggc 3607 Leu Lys Ser Val Leu Ile Ile Ala His Lys Leu Leu Val 700 705 agcctctcgctgcctctcgcctcgcc 3667 acttctgcaa cagattctgt ttctttttcc cgactctttt ccttgctgcc aggtatgtga 3727 tgctgtaggc ttggctccaa accagctgag tgcctgcttt ttactccttt atgtctggcc 3787 ttctaggatc tgtccaagac actctcaggc ctggaggcag ggcatagaat cagttcttca 3847 ctctccctaa tactacactc tgtaaggacc tggggcagga tatcttctcc cccagggatc 3907 ttctatttaa gtggcttctg agagggtgaa caggattgtt acttttaagc ctacctctgc 3967 tgtgacccat catgtgggtc ttttgtttct cccttctgtg gtttatgagc ctgcccttac 4027 cttttccctg cctctgactt ggtatttcca ggtccgtatt tctctgtagc ccagggtctg 4087 gggtagagct gactgctgtt caccctttga acaactcatg gacgtgaggg atgggtgctg 4147 agcagaacca agagaggaaa ctttggcgct gttaaaatgg aatttctcat ctgccggcat 4207 tattaagggt gggctaggtt gggctaggtg gg gg gg gg gg gg gg gg gg gg gg gg gg gg gg gg gg gg ct gg cacagcc tatggggaac tgcccttgac 4327 tccacctatg ttggagcctt agcccaaggc cattccttct gtgatgataa agcccagttc 4387 tggaattgga gccatattaa ggaatgattc tcttccagcg ctgctcctca agggttgggg 4447 gtccttctcc ctcgcagcca ccacatgtct cagggctacc ttctccgatt ggatttgcat 4507 ttgtggcact gtctttgatg cagtgatgta cttaatggtg caataaagct gcttcgattt 4567 gg 4569 <210> 193 <211> 4256 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (53) .. (3175) <400> 193 cacagaggtg cagagaggtg acataacttc cccaacatca cctgcttagt aa gca tca 58 Ala Ser 1 tgg gag ggg cag agc cac gtg acc caa gct tat gag gag gct gtg ggc 106 Trp Glu Gly Gln Ser His Val Thr Glu Alu 10 15 cca ccc cag cca caa gtc cca gat tct act ggg gac cgt cat cct ttg 154 Pro Pro Gln Pro Gln Val Pro Asp Ser Thr Gly Asp Arg His Pro Leu 20 25 30 tgg gga ttg gga ggg ttt ggc cag gag cac ccc tgg gaa ggg cag att 202 Trp Gly Leu Gly Gly Phe Gly Gln Glu His Pro Trp Glu Gly Gln Ile 35 40 45 50 tta ggg ggt tct tct cag gct gaa cct ggc ctg gtc tgg tcc aca gga 250 Leu Gly Gly Ser Ser Gln Ala Glu Pro Gly Leu Val Trp Ser Thr Gly 55 60 65 tct gta atg gtg aag tcc ccc atg aat cgg gag ctg gtt gcc acc tat 298 Ser Val Met Val Lys Ser Pro Met Asn Arg Glu Leu Val Ala Thr Tyr 70 75 80 gag gtc act ctc tca gtg att gac aat gcc agc gac cta cca gag cgc 346 Glu Val Thr Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg 85 90 95 tct gtc agt gtg cca aat gcc aag ctg act gtc aac gtc ctg gac 394 Ser Val Ser Val Pro Asn Ala Lys Leu Thr Val Asn Val Leu Asp Val 100 105 110 aat gac aat acg ccc cag ttc aag ccc ttt ggg atc acc tac tac atg 442 Asn Asp Asn Thr Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr Tyr Met 115 120 125 130 gag cgg atc ctg gag ggg gcc acc cct ggg acc aca ctc att gct gtg 490 Glu Arg Ile Leu Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile Ala Val 135 140 145 gca gcc gtg gac cct gac aag ggc ctt aat ggg ctg gtc acc tac acc 538 Ala Ala Val Asp Pro Asp Lys Gly Leu Asn Gly Leu Val Thr Tyr Thr 150 155 160 ctg ctg gac ctg gtg ccc cca ggg tat gtc cag ctg gag gac tcc tcg As Leu Leu Val Pro Pro Gly Tyr Val Gln Leu Glu Asp Ser Ser 165 170 175 gca ggg aag gtc att gcc aac cgg aca gtg gac tac gag gag gtg cac 634 Ala Gly Lys Val Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu Val His 180 185 190 tgg ctc aac ttt acc gtg agg gcc tca gac aac ggg tcc ccg ccc cgg 682 Trp Leu Asn Phe Thr Val Arg Ala Ser Asp Asn Gly Ser Pro Pro Arg 195 200 205 210 gca gct gag atc cct gtc tac ctg gaa atc gtg gac atc aat gac aac 730 Ala Ala Glu Ile Pro Val Tyr Leu Glu Ile Val Asp Ile Asn Asp Asn 215 220 225 aac ccc atc ttt gac cag ccc tcc tac cag gag gct gtc ttt gag gat 778 Asn Pro Ile Phe Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe Glu Asp 230 235 240 gtg cct gtg ggc aca atc atc ctg aca gtc act gcc act gat gct gac 826 Val Pro Val Gly Thr Ile Ile Leu Thr Val Val Ala Thr Asp Ala Asp 245 250 255 tca ggc aac ttt gca ctc att gag tac agc ctt gga gat gga gag agc 874 Ser Gly Asn Phe Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly Glu Ser 260 265 270 aag ttt gcc atc aac ccc acc acg ggt gac atc tat gtg ctg tct tct 922 Phe Ala Ile Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu Ser Ser 275 280 285 290 ctg gac cgg gag aag aag gac cac tat atc ctg act gcc ttg gcc aaa 970 Leu Asp Arg Glu Lys Lys Asp His Tyr Ile Leu Thr Ala Leu Ala Lys 295 300 305 gac aac cct ggg gat gta gcc agc aac cgt cgc gaa aat tca gtg cag 1018 Asp Asn Pro Gly Asp Val Ala Ser Asn Arg Arg Glu Asn Ser Val Gln 310 315 320 gtg gtg atc caa gtg ctg gat gtg at gac tgc cgg cca cag ttc tcc 1066 Val Val Ile Gln Val Leu Asp Val Asn Asp Cys Arg Pro Gln Phe Ser 325 330 335 aag ccc cag ttc agc aca agc gtg tat gag aat gag ccg gcg ggc acc 1114 Lys Pro Gln Phe Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala Gly Thr 340 345 350 tcg gtc atc acc atg atg gcc act gac cag gat gaa ggt ccc aat gga 1162 Ser Val Ile Thr Met Met Ala Thr Asp Gln Asp Glu Gly Pro Asn Gly 355 360 365 370 gag ttg acc tac tca ctt gag ggc cct ggc gtg gag gcc ttc cat gtg 1210 Glu Leu Thr Tyr Ser Leu Glu Gly Pro Gly Val Glu Ala Phe His Val 375 380 385 gac atg gac tcg ggc ttg gtg acc aca cag cgg cag tcc tac 1258 Asp Met Asp Ser Gly Leu Val Thr Thr Gln Arg Pro Leu Gln Ser Tyr 390 395 400 gag aag ttc agt ctg acc gtg gtg gcc aca gat ggt gga gag ccc cca 1306 Glu Lys Phe Ser Leu Thr Val Val Ala Thr Asp Gly Gly Glu Pro Pro 405 410 415 ctc tgg ggc acc acc atg ctc ctg gtg gag gtc atc gac gtc aat gac 1354 Leu Trp Gly Thr Thr Met Leu Leu Val Glu Val Ile Asp Val Asn Asp 420 425 430 430 aac cgc cct gt c ttt gtg cgc cca ccc aac ggc acc atc ctc cac atc 1402 Asn Arg Pro Val Phe Val Arg Pro Pro Asn Gly Thr Ile Leu His Ile 435 440 445 450 aga gag gag atc ccg ctg cgc tcc aac gtg tac gag gtc tac gcc 1450 Arg Glu Glu Ile Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr Ala Thr 455 460 465 gac aag gat gag ggc ctc aac ggg gcg gtg cgc tac agc ttc ctg aag 1498 Asp Lys Asp Glu Gly Leu Asn Tly Ala Val Phe Leu Lys 470 475 480 act gcg ggc aac cgg gac tgg gag ttc ttc atc atc gac cca atc agc 1546 Thr Ala Gly Asn Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro Ile Ser 485 490 495 495 ggc ctc atc cag act g ctg gac cgc gag tcg cag gcg gtg 1594 Gly Leu Ile Gln Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln Ala Val 500 505 510 tac agc ctc atc ttg gtg gcc agc gac ctg ggc cag cca gtg Leca Serac Val Ala Ser Asp Leu Gly Gln Pro Val Pro Tyr 515 520 525 530 gag act atg cag ccg ctg cag gtg gcc ctg gag gac atc gat gac aac 1690 Glu Thr Met Gln Pro Leu Gln Val Ala Leu Glu Asp Ile Asp Asp Asn 535 540 545 gaa ccc ctt ttc gtg agg cct cca aaa ggc agc ccc cag tac cag ctg 1738 Glu Pro Leu Phe Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr Gln Leu 550 555 560 ctg aca gtg cct gag cac tca cca ccc gtg ggc aac gtg 1786 Leu Thr Val Pro Glu His Ser Pro Arg Gly Thr Leu Val Gly Asn Val 565 570 575 aca ggc gca gtg gat gca gat gag ggc ccc aac gcg atc gtg tac tac 1834 Thr Gly Ala Val Asp Ala Asp Glu Gly Pro Asn Ala Ile Val Tyr Tyr 580 585 590 ttc atc gca gcc ggc aac gaa gag aag aac ttc cat ctg cag ccc gat 1882 Phe Ile Ala Ala Ala Gly Asn Glu Glu Lys Asn Phe His Leu Gln Pro Asp 595 600 605 610 ggg tgt ctg gtg ctg cgg gac ctg gac cgg gag cga gaa gcc atc 1930 Gly Cys Leu Leu Val Leu Arg Asp Leu Asp Arg Glu Arg Glu Ala Ile 615 620 625 ttc tcc ttc atc gtc gtc aag gcc tcc agc ac cgc ag cc cat cgccatcgccatcgcc Phe Ser Phe Ile Val Lys Ala Ser Ser Asn Arg Ser Trp Thr Pro Pro 630 635 640 cgt gga ccc tcc cca acc ctc gac ctg gtt gct gac ctc aca ctg cag 2026 Arg Gly Pro Ser Pro Thr Leu Asp Leu Val Ala Asp Leu Thr Leu Gln 645 650 655 gag gtg cgc gtt gtg cta gag gac atc aac gac cag cca cca cgc ttc 2074 Glu Val Arg Val Val Leu Glu Asp Ile Asn Asp Gln Pro Pro Arg Phe 660 665 670 670 acc aag gct gag tac gca ggg gtg gcc acc gac gcc aag gtg ggc 2122 Thr Lys Ala Glu Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys Val Gly 675 680 685 690 tca gag ttg atc cag gtg ctg gcc ctg gat gca gac att ggc aac Leacu 2170 Ser Ile Gln Val Leu Ala Leu Asp Ala Asp Ile Gly Asn Asn 695 700 705 agc ctt gtc ttc tac agc att ctg gcc atc cac tac ttc cgg gcc ctt 2218 Ser Leu Val Phe Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg Ala Leu 715 720 gcc aac gac tct gaa gat gtg ggc cag gtc ttc acc atg ggg agc atg 2266 Ala Asn Asp Ser Glu Asp Val Gly Gln Val Phe Thr Met Gly Ser Met 725 730 735 gac ggc att ctg cgc acc ttc gacgcc cc tac agc ccc ggc 2314 Asp Gly Ile Leu Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser Pro Gly 740 745 750 tac ttc gtg gtg gac att gtg gcc cga gac ctg gca ggc cac aac gac 2362 Tyr Phe Val Asp Ile Val Ala Arg Asp Leu Ala Gly His Asn Asp 755 760 765 770 acg gcc atc atc ggc atc tac atc ctg agg gac gac cag cgc gtc aag 2410 Thr Ala Ile Ile Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg Val Lysc 775 780 gtc att aac gag atc ccc gac cgt gtg cgc ggc ttc gag gag gag 2458 Ile Val Ile Asn Glu Ile Pro Asp Arg Val Arg Gly Phe Glu Glu Glu Glu 790 795 800 ttc atc cac ctg ctc tcc aac atc act ggg gcc att gac 2506 Phe Ile His Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr Asp 805 810 815 aat gtg cag ttc cat gtg gac aag aag ggc cgg gtg aac ttt gcg cag 2554 Asn Val Gln Phe His Val Asp Lys Lys Gly Arg Val Asn Phe Ala Gln 820 825 830 aca gaa ctg ctt atc cac gtg gtg aac cgc gat acc aac cgc atc ctg 2602 Thr Glu Leu Leu Ile His Val Val Asn Arg Asp Throne Asn Arg Ile Leu 835 840 845 850 850 gac gtg gcgg cag atg atc gat gag aac aag gag cag cta 2650 Asp Val Asp Arg Val Ile Gln Met Ile Asp Glu Asn Lys Glu Gln Leu 855 860 865 cgg aat ctt ttc cgg aac tac aac gtc ctg gac gtg cag cct gcc atc 2698 Arg sn Leu Phe Arg Asn Tyr Asn Val Leu Asp Val Gln Pro Ala Ile 870 875 880 tct gtc cgg ctg ccg gat gac atg tct gcc ctg cag atg gcg atc atc 2746 Ser Val Arg Leu Pro Asp Asp Met Ser Ala Leu Gln Met Ala Ile Ile 885 890 895 gtc ctg gct atc ctc ctg ttc ctg gcc gcc atg ctc ttt gtc ctc atg 2794 Val Leu Ala Ile Leu Leu Phe Leu Ala Ala Met Leu Phe Val Leu Met 900 905 910 aac tgg tac tac agg act aag ctc aag gcc att gtg 2842 Asn Trp Tyr Tyr Arg Thr Val His Lys Arg Lys Leu Lys Ala Ile Val 915 920 925 930 gct ggc tca gct ggg aat cgt ggc ttc atc gac atc atg gac atg cct 2890 Ala Gly Ser Ala Gly Arg Gly Phe Ile Asp Ile Met Asp Met Pro 935 940 945 aac acc aac aag tac tcc ttt gat gga gcc aac cct gtg tgg ctg gat 2938 Asn Thr Asn Lys Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp Leu Asp 950 955 960 ccc ttc tgt cgg aac ctg gag ctg gcc gcc cag gcg gag cat gag gat 2986 Pro Phe Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp 965 970 975 gac cta ccg gag aac ctg agt gag atc gcc gac gcct agc ccc 3034 Asp Leu Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro 980 985 990 acg cgc acc cat gga act ttt ggg cgt gag cca gca gct gtc aag cct 3082 Thr Arg Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro 995 1000 1005 1010 gat gat gac cga tac ctg cgg gct gcc atc cag gag tat gac aac att 3130 Asp Asp Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile 1015 1020 1025 gcc aag cag gg atc att cgt gag ggg cca atc aag gca gtt 3175 Ala Lys Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Ala Val 1030 1035 1040 tgagaaacag agtctgacag gcctgctgcg gtaggagccc aaggttcagc cacatagcca 3235 gtgggtctct ggggccatcc acctgctcac cccttgggca tggccctgag catgtggggg 3295 tcccggcctc ttgcagctga tacagactga gctggacgag gagccaggag accacagccc 3355 agggcagggt agcctgcgct tccgccacaa gccaccagtg gagctcaagg ggcccgatgg 3415 gatccatgtg gtgcacggca gcacgggcac gctgctggcc accgacctca acagcctgcc 3475 cgaggaagac cagaagccc gcgccc gcgcc gcccgccc gccc gccc gccc gccc gccc gccc acacccctgc acaaacttcg 3595 cgacgtgatc atggagaccc ccctggagat cacagagctg tgactagaca gggaagcctt 3655 gtgggtgtga gcagcaccca tccaccgtcc cctcccaggg agcaagggca gggacagggc 3715 cggtcggggg ggaccctcca aggccaggcc ttggggacaa ccttggcttg gccctggcag 3775 cccgcatcag ctgctcagat cccacttttg ccagacgctc attcagcatc tgacctctac 3835 cttcataaga tctgttattt ttataagaaa accaaacaaa aatgttaagc atctaaggac 3895 aaggtaagga gggtcactgg ggcccaagag tctggggacc agcttggctc aggctgagct 3955 gaaagaggcc aaacaggccc tcctccctcc cggctccacc ccgcaagcac catcccctcc 4015 ggctaagcag gcgcaaggga ggcccagcgc ggacatcccc tgctggccgg acacccgact 4075 ccagtccaag tctcgctaca tttccgccac atccctctct gctggacgtc caggtggagg 4135 tggcatcccc acgtggacaa gaaagtcaat gtcaatgaac aagcattctc tccatttcac 4195 tggcttccca aatgtgtgcc cagcttataa acagaagtga ctgatgttcc ctccggtttt 4255 g 4256 <210> 194 <211> 6992 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (106) .. (1365) <400> 194 gcagcggcca aggcggcaca ccggagcctc cgaggcgagg ggcaagtggg cgaagggagg 60 ggggacgacg gctgctgccg cagcagctga aggccaagga attga aag ggc tgt agg 117 Lys Gly Cys Arg 1 ggg agg cag tgc gag cca gcc ccg act gct cct cct ctt cct cct cct 165 Gly Arg Gln Cys Glu Pro Ala Pro Thr Ala Pro Pro Leu Pro Pro Pro 5 10 15 20 cct cca aac tcg cga gcc cca gag ctc gct cag ccg ccg gga gca ccc 213 Pro Pro Asn Ser Arg Ala Pro Glu Leu Ala Gln Pro Pro Gly Ala Pro 25 30 35 aga ggg acg gga ggc agc cgc gca gcc ccg agc tgg gca gtg tcc cca 261 Arg Gly Thr Gly Gly Ser Arg Ala Ala Pro Ser Trp Ala Val Ser Pro 40 45 50 gcc gcc atg gat agc gac gac gag atg gtg gag gag gcg gt ggg 309 Ala Ala Met Asp Ser Asp Asp Glu Met Val Glu Glu Ala Val Glu Gly 55 60 65 cac ctg gac gat gac gga tta ccg cac ggg ttc tgc aca gtc acc tac 357 His Leu Asp Asp Asp Gly Leu Pro His Gly Phe Cys Thr Val Thr Tyr 70 75 80 tcc tcc aca gac aga ttt gag ggg aac ttt gtt cac gga gaa aag aac 405 Ser Ser Thr Asp Arg Phe Glu Gly Asn Phe Val His Gly Glu L ys Asn 85 90 95 100 gga cgg ggg aag ttc ttc ttc ttt gat ggc agc acc ctg gag ggg tat 453 Gly Arg Gly Lys Phe Phe Phe Phe Asp Gly Ser Thr Leu Glu Gly Tyr 105 110 115 tat gtg gat gat gcc ttg cag cag gga gtt tac act tac gaa gat 501 Tyr Val Asp Asp Ala Leu Gln Gly Gln Gly Val Tyr Thr Tyr Glu Asp 120 125 130 ggg gga gtt ctc cag ggc acg tat gta gac gga gag ctg aac ggt cca 549 Gly Gly Val Leu Gln Gly Thr Tyr Val Asp Gly Glu Leu Asn Gly Pro 135 140 145 gcc cag gaa tat gac aca gat ggg aga ctg atc ttc aag ggg cag tat 597 Ala Gln Glu Tyr Asp Thr Asp Gly Arg Leu Ile Phe Lys Gly Gln Tyr 150 155 160 aaa gat aac att cgt cat gga gtg tgc tgg ata tat tac cca gat gga 645 Lys Asp Asn Ile Arg His Gly Val Cys Trp Ile Tyr Tyr Pro Asp Gly 165 170 175 180 gga agc ctt gta gga gaa gta aat gaa gat ggg atg act gga gag 693 Gly Ser Leu Val Gly Glu Val Asn Glu Asp Gly Glu Met Thr Gly Glu 185 190 195 aag ata gcc tat gt gtg tac cct gat gag agg acc gca ctt tat ggg aaa 741 Lys Ile Ala Tyr Val Tyr Pro Asp Glu Arg Thr Ala Leu Tyr Gly Lys 200 205 210 ttt att gat gga gag atg ata gaa ggc aaa ctg gct acc ctt atg tcc 789 Phe Ile Asp Gly Glu Met Ile Glu Gly Lys Leu Ala Thr Leu Met Ser 215 220 225 act gaa gaa ggg agg cct cac ttt gaa ctg atg cct gga aat tca gtg 837 Thr Glu Glu Gly Arg Pro His Phe Glu Leu Met Pro Gly Asn Ser Val 230 235 240 tac cac ttt gat aag tcg act tca tct tgc att tct acc aat gct ctt 885 Tyr His Phe Asp Lys Ser Thr Ser Ser Cys Ile Ser Thr Asn Ala Leu 245 250 255 260 ctt cca gat cct tat gaa tca gaa agg gtt tat gtt gct gaa tct ctt 933 Leu Pro Asp Pro Tyr Glu Ser Glu Arg Val Tyr Val Ala Glu Ser Leu 265 270 275 att tcc agt gct gga gaa gga ctt ttt tca aag gta gct gtg gga cct 981 Ile Ser Ser Ala Gly Glu Gly Leu Phe Ser Lys Val Ala Val Gly Pro 280 285 290 aat act gtt atg tct ttt tat aat gga gtt cga att aca cac caa gag 1029 Asn Thr Val Met Ser Phe Tyr Asn Gly Val Arg Ile Thr His Gln Glu 295 300 305 gtt gac agc agg gac tgg gcc ctt aat ggg aac acc ctc tcc ctt gat 1077 Val Asp Ser Arg Asp Trp Ala Le u Asn Gly Asn Thr Leu Ser Leu Asp 310 315 320 gaa gaa acg gtc att gat gtg cct gag ccc tat aac cac gta tcc aag 1125 Glu Glu Thr Val Val Ile Asp Val Pro Glu Pro Tyr Asn His Val Ser Lys 325 330 335 340 tac tgt gcc tcc ttg gga cac aag gca aat cac tcc ttc act cca aac 1173 Tyr Cys Ala Ser Leu Gly His Lys Ala Asn His Ser Phe Thr Pro Asn 345 350 355 tgc atc tac gat atg ttt gtc cac ccc cgt ttt ggg ccc atc aaa tgc 1221 Cys Ile Tyr Asp Met Phe Val His Pro Arg Phe Gly Pro Ile Lys Cys 360 365 370 atc cgc acc ctg aga gca gtg gag gcc gat gaa gag ctc acc gtt gcc 1269 Ile Arg Thr Leu Arg Ala Val Glu Ala Asp Glu Glu Leu Thr Val Ala 375 380 385 tat ggc tat gac cac agc ccc ccc ggg aag agt ggg cct gaa gcc cct 1317 Tyr Gly Tyr Asp His Ser Pro Pro Gly Lys Ser Gly Pro Glu Ala Pro 390 395 400 gag tgg tac cag gtg gag ctg aag gcc ttc cag gcc acc cag caa aag 1365 Glu Trp Tyr Gln Val Glu Leu Lys Ala Phe Gln Ala Thr Gln Gln Lys 405 410 415 420 tgaaaggcct ggctttgggg ttcagagacc tggaatagaa acttggatct atgcactacg 1425 tttat ctgac aatgggacaa ccagggactg ctcatgctgt gacgtcacat cctctcacca 1485 tgcgttagca acgactttct cgcatactaa ctaggtttga ctgtattact cataccagat 1545 ttaaaattag ctagccttgc aacaacgtcc tactgagagg tattgtcgag catttgacat 1605 aagacagcgt gatgttcttt ggtggttcaa gtctaaatct gtaccacatt cggagatgcc 1665 aaatgattag actgaaacag ggaaacgggg tttttcagtc atttttagtc agtggttttt 1725 ccatagtgct tttttcctat ggccagtgca aattgtgtta gcacacttgc atatgtgccg 1785 tattaagggt tgacaattac tacatcttta ttctctaaat gtagtataat ttgcctttta 1845 acctttgatc tgtatcttgc aatagaatgg ctttggtttt tttcttagta aataggagcc 1905 cacttctaaa gtcatttcac ccctcagccc tattctcttt cttagatacc ctttacaaga 1965 gaaaacttcc aaatggattt ttgcatcaat agcagtgtgt aggtctctct ggttctttct 2025 atatcatcat tttattatta tgtcctaata taaagtactg gctcataggg ccagggtatt 2085 attatagaat attattctcg catgtaaaca aagatatctt tgctttaaga tgtgagaaga 2145 aatgaattta ctttgtttgc attaagttat ggaagagttg taatatatac tttaagaaag 2205 aagagaagaa aactagtatc tctaagcggt aactatggca attttgcaat attttcagta 2265 gtgctagtaa ttttttcctc cttgagtaca cattaaatgt acataacata gcgcggtcag 2325 gcttgtggca cagtgcattg aattcaaaag tcaaacagca aatttgaatt ctaacagaat 2385 tcaaaaaaaa atttttttag tcagtactac taaggcagac acactgatta ctaggtacaa 2445 atcaaacctt gatgctaaaa ctcttcatca ttgtaatttc aaagcactta cctgcttcaa 2505 aacattgtaa actaagactg aacacctgta tagtttaaaa gcaacactat caatagcatt 2565 tcagccattt tgccagccat gtgtaatcac aactgcagaa ataaggagaa aacccctgtt 2625 tttttagttt agctaattag atctgtaaca tcactgggat tgctctgaat gaatcctgag 2685 agttttgttt tttataagca ccctcaccac atgccatagc tttgtctctt ttagacacct 2745 cgatgcagcg gctggaagga ctggagagca gctgttgtgc tgatctgtag ctgtcagctg 2805 tgattcctgt cacctgagtc agtttggtct ggaaagcgaa ggccttccaa gctgtagcag 2865 atagtgagct ccagctgatg agagaaggct tcagtggaag aagagtgagg acataggcag 2925 aaggaagttt gctatttctt gtcagttgca cattgcttta tgaagactac aacaaaagtg 2985 cttaatccca ggctgctcat gactttcatt tcaggtggcc cttgggcaca ttgacagagt 3045 tgcccttccc ttctttgcaa caccaggctt cctagagcac ccggttgcat gctttgcagc 3105 taggtggcag tggtt tcagg gagatccagt tggatccctg cttgaaagct taagccaatg 3165 gttcacccat gagaggaagt tgtcagtgct tccaggaaga ttgcccacca aaggaactga 3225 atagttttta gatttaaagg caccaggata gggtcactct tactctgtag aaagagaccg 3285 ttctatacac tgtgacggat gggccagggc ctctggactt gcattctgat aggtgcttta 3345 atttaaatgt gcccaaaggg agtgactgtc ttcaggagaa agatggcttg cattaacctc 3405 gatcaagtgg gttgtgcagc caggtcaggg aatgcggtca gggagaggat agtgctggtc 3465 atgcccccga tgcagctatg ctctgaatga tttcattcct gagagtgata gcattctggt 3525 cctggctgca gtggggtaca atttacgtcc taagtggggg ctactctaat tatcccattc 3585 aaatggaatt tttttcaaaa ttggatagaa ggaattgaag agttgtaagt agtgattagt 3645 ctgctaatca gttcttcaga tgagatattg aatggtaaca ctctgagctt aaaactcagc 3705 agtgtgtctg tgacctccac gcaaatcaga ggaagcaatg catccacgct gagcctcacc 3765 atgtcttcct cccaactctc ttcatactct ctgtgtcttc cagctcttct ttctctggcc 3825 ggctctcttt cctcttctct ctgcatatgt gagaacgcct gggcatcctg ggtaacagca 3885 gccccagctg ccctctcctg ttccctgttc caagtcccct gcactgacct ttcttgagtc 3945 tctctggctc tgtgcatgtc tttgggactc tcctcatctg gcttttcctc tgtgtgtgcc 4005 tctctgtttg cttatgtctc tggctctgtc ttccccaccc ctcccctcac acacacacat 4065 actcccaaat gtaaggctct gtggcaggtt ggaatcggag taaggcttga gattcactga 4125 gttctgtagg tagggaaaga agtcaaggga gtggaggttc tataaggaat taacagctga 4185 ggacggaagg gtttgtttcc cgtttgaacc taaacgcaag tggaaaagaa tactcagaat 4245 gtatttttct actttacatc tgctggggaa ggaaatgtgt caggaagccg ctgcatctgg 4305 tcatttcatc gcatcagaat cacagcagac gtggaagatt ccatgtggtg gggaataaag 4365 aaataacttt atgctctcct gaaaaacagc gggagcctat gtgtgtgtgc gacactgtaa 4425 tctcaaggag attcactcag agctgtctca gtccaactcc tgcatgacca gatcttccct 4485 tagcatcttt tctgtgatga aatattatct tgtgttagag ttaggaatag gaactaacct 4545 gtaggagcat gtccccaaat ggacatttga atggactaac aaaaacaact ggaaagactg 4605 aatttccgac acaaaggaat gatgagatca aaaagaaagc agtgaggagt tcttgagtct 4665 tgtagtacct attcttattt taacttgctt catccttgat ctacctgaga cactaagaag 4725 gaaattagtt ttccaagagc tctttgaacc tgtctaggac tgtagttaaa cctatttgcc 4785 ctatgggggt tcttcacact cgaa aaacta tttccttatc accaacgacc cacccagaaa 4845 ggccaatgag gccaaatgta acaattttta acatttaaat ataactatta aaattgcatt 4905 aattgtgaac agtgaattaa agggttgtct tctccaggag acagtatgtg gcacttttcg 4965 taaatttcat ttaatatata aaaatttaaa tcactcactg caacatgcat ttaaaatctt 5025 ccaagaaggt agaggtatca ttttctgttt tgctttgttt taaaacagtt gcctcaagct 5085 tctgtcttaa gagtagtgac ttagaatcca gatatctttt gttttagaaa aacaagcaaa 5145 actatgttgc aagactgaca gttgtaatgt ttatttgcca cagatcaaag gttcacaaag 5205 tatatcaaat ttacatctac ttggggtacc ttgatagatt attattgttt ttcttttatc 5265 tttcccttca ggaatttgga aactcgttgt cacttttttt aattttaaaa atactaaatt 5325 gtaatagttt tcttttgcca aatgtgtgcg tacatattca aagcaatgaa actatttcaa 5385 gccatacaac cacaggggtg ggaacccttt tcacaaattt taatgtgttt gtatgtaaat 5445 agatgtttgt atgaaatatt ttcatgatag aatgaatata tttaaatgaa gttgaattat 5505 tccagtgcta cttaaacaca ttacaaaaat tttggtgaga attatctgag tctattgaga 5565 tgtaatgcag atcaattttg atttttaaaa atcaaaagcc tacaataact ctgactctca 5625 gcaacttcct cggcgttgtt gcacctgacg tggagagagc tcgtaggctt ccccagtgcc 5685 tcagccgctt cctggtggaa gttaggtgct aatggaggtg tgttcacctt ttagtgatat 5745 cactgcaggc ctttgagggg cctgagagtg aatcagaggc attagagaca ccggtgcagt 5805 tatctggagc acaatttctt tgcagggcag cagaatcaga agccagactt ggccatgtga 5865 acctcgaaac tcggtttccc ggccgccatc aaccgccacc cttactgcct agtcacacac 5925 gtcagggagg ctgccctcag tggagttggg gttgagaccc cagggtggga cttcacagtt 5985 ttgccagcaa tctctacctt ctgacttctg cctcgcagag aggaaggaga ggggagcatc 6045 tggcaagggg cccatttctc agcacagtac atttcctgtc tcagctctgg aagactatgc 6105 acccaagcac caaacttcca accagagaga gagacgtcct ccgataacaa aaatccttgc 6165 ttcctctgtc tgtgacttta cacacagttg ttcaaagttg ttaaatgtca agagtcaatc 6225 acatccctag gacatacctc ccaactctcc tgactcttat gttattgaaa aaacaaacaa 6285 acaaaaactc ctttatgatg atattcaact tgagtggggt tttttttcca ctttggtcct 6345 ggatataatg aaatgataca tattaggata aattttcact gtgtatagta gcaatacgaa 6405 cacacatgcc aatgtatcaa catatctact tggttacatt ttggtttatg ataattaacc 6465 ttgattcatg tattgggaag ctacagggac tacg taatac ctgcttatca cataggaaaa 6525 ttatgtccat gattctgagc tcccttcttc aaaagtttcc tcctgggtgt tctatgttct 6585 ctctttatcc tgaaatacat ttattaggtt gtgaggtatg ttgaagaagt agaagccagg 6645 ggtatgcttt cagcatttat tgcaaccaaa agttaacccc atcacggtta acgagcatct 6705 ttggtctctt gtggaatttg aactaaaact atgagcctta ttcaatatct ataattctat 6765 gattttttta aattatggga aattaatgaa agatgtttac atgaataatg tttgccctta 6825 ctgtgttatg aatgagtttt ttgtagtgtg tctgggtgca tgatgcaaga gagtaggaaa 6885 aatgtttctg aaacaaaact tgacaaatat ttgtaatgaa agtaaattta aagattgcta 6945 taattgcgct atagaaacaa tgcaagtatt aaacaaaata tacaatc 6992 <210> 195 <211> 7244 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (2688) <400> 195 gac gtc tcc ctc tac aag gag ggc aat agc ttt ggc ttt gtc ctt aga 48 Asp Val Ser Leu Tyr Lys Glu Gly Asn Ser Phe Gly Phe Val Leu Arg 1 5 10 15 gga ggt gcc cat gaa gat ggg cac aag tcc cgc ccg ctt gtc ctg acc 96 Gly Gly Ala His Glu Asp Gly His Lys Ser Arg Pro Leu Val Leu Thr 20 25 30 tac gtg cgg ccc ggt ggc cct gcc gac agg gag ggc tcc ctg aag gtg 144 Tyr Val Arg Pro Gly Gly Pro Ala Asp Arg Glu Gly Ser Leu Lys Val 35 40 45 ggc gac agg ctg ctc agc gtc gat gga atc ccg ctg cac ggg gcc agc 192 Gly Asp Arg Leu Leu Ser Val Asp Gly Ile Pro Leu His Gly Ala Ser 50 55 60 cat gcc acc gcc ctg gcc acc ctg cgg cag tgc agc cac gag gca ctc 240 His Ala Thr Ala Leu Ala Thr Leu Arg Gln Cys Ser His Glu Ala Leu 65 70 75 80 ttt cag gtg gag tat gat gtg gcc acc cct gac acg gtg gct aat gct 288 Phe Gln Val Glu Tyr Asp Val Ala Thr Pro Asp Thr Val Ala Asn Ala 85 90 95 tcg gga ccc ttg atg gtg gaa ata gtc aag acg cca ggg tct gcc ctg 336 Ser Gly Pro Leu Met Val Glu Ile Val Lys Thr Pro Gly Ser Ala Leu 100 105 11 0 ggg atc tcg ctc acc acc acc tcc ctc cgg aac aag tca gtc att acc 384 Gly Ile Ser Leu Thr Thr Thr Ser Leu Arg Asn Lys Ser Val Ile Thr 115 120 125 atc gac cgc atc aag cca gcc agc gtg gtg gac agg agc gga gcc ctg 432 Ile Asp Arg Ile Lys Pro Ala Ser Val Val Asp Arg Ser Gly Ala Leu 130 135 140 cac cct gga gac cac atc ctg tcc atc gat ggc acc agc atg gaa cac 480 His Pro Gly Asp His Ile Leu Ser Ile Asp Gly Thr Ser Met Glu His 145 150 155 160 tgc tcg ctg ctt gag gcc acc aag ctc ctg gcc agc att tca gag aag 528 Cys Ser Leu Leu Glu Ala Thr Lys Leu Leu Ala Ser Ile Ser Glu Lys 165 170 175 gtg cgg ctg gag atc ctg cct gtg ccc cag agt cag cgg cca ctg agg 576 Val Arg Leu Glu Ile Leu Pro Val Pro Gln Ser Gln Arg Pro Leu Arg 180 185 190 ccc tca gag gca gtg aaa gtg cag agg agt gag cag ctg cac cgc tgg 624 Ser Glu Ala Val Lys Val Gln Arg Ser Glu Gln Leu His Arg Trp 195 200 205 gac ccc tgc gtg ccc tcc tgc cac agc ccc cgg ccc ggc cac tgc agg 672 Asp Pro Cys Val Pro Ser Cys His Ser Pro Arg Pro Gly His Cys Ar g 210 215 220 atg ccc acc tgg gcc aca cct gct ggc cag gac caa agc cga tcc ttg 720 Met Pro Thr Trp Ala Thr Pro Ala Gly Gln Asp Gln Ser Arg Ser Leu 225 230 235 240 tct tca act ccc ttt tcc tcg ccg acc ttg aac cac gcc ttt tcc tgc 768 Ser Ser Thr Pro Phe Ser Ser Pro Thr Leu Asn His Ala Phe Ser Cys 245 250 255 aac aac ccc agc acc ctt ccc cgt gga tcc cag ccc atg agt cct cga 816 Asn Asn Pro Ser Thr Leu Pro Arg Gly Ser Gln Pro Met Ser Pro Arg 260 265 270 270 act aca atg ggg cgg agg agg cag cga aga agg gaa cac aag agc tcg 864 Thr Thr Met Gly Arg Arg Arg Gln Arg Arg Arg Glu His Lys Ser Ser 275 280 285 285 ttg tcg cta gcc tcc agc acg gtg ggg ccg ggc ggg cag att gtg cac 912 Leu Ser Leu Ala Ser Ser Thr Val Gly Pro Gly Gly Gln Ile Val His 290 295 300 acg gag acc acg gag gtc gtg ctc tgt gga gac ccc ctc ag ttt 960 Thr Glu Thr Thr Glu Val Val Leu Cys Gly Asp Pro Leu Ser Gly Phe 305 310 315 320 ggc ctc cag ctc cag ggc ggc atc ttc gcc acc gag acc ctg tcc tcc 1008 Gly Leu Gln Leu Gln Gly Gly Ile Phe Ala ThrGlu Thr Leu Ser Ser 325 330 335 cca ccc ctc gtg tgc ttc atc gag cct gac agc ccg gct gag agg tgt 1056 Pro Pro Leu Val Cys Phe Ile Glu Pro Asp Ser Pro Ala Glu Arg Cys 340 345 350 ggg ctg ctg cag gg g gac cgt gtc ctg tcc atc aat ggc att gcc 1104 Gly Leu Leu Gln Val Gly Asp Arg Val Leu Ser Ile Asn Gly Ile Ala 355 360 365 acc gag gac ggg act atg gag gaa gcc aac cag ctc ctg cgg gac gcc 1152 Thr Glu As Gly Thr Met Glu Glu Ala Asn Gln Leu Leu Arg Asp Ala 370 375 380 gcg ctg gcc cac aag gtc gtg ctg gag gtg gag ttc gat gtg gcg gag 1200 Ala Leu Ala His Lys Val Val Leu Glu Val Glu Phe Asp Val Ala Val 390 395 400 tcc gtc atc cca agc agt ggc acc ttc cac gtg aag ctg ccc aag aag 1248 Ser Val Ile Pro Ser Ser Gly Thr Phe His Val Lys Leu Pro Lys Lys 405 410 415 cgc agc gtg gag ctg ggc atc acc atc ag ag gcc agc agg aaa cga 1296 Arg Ser Val Glu Leu Gly Ile Thr Ile Ser Ser Ala Ser Arg Lys Arg 420 425 430 ggg gag ccc ttg atc atc tcc gac atc aag aaa ggc agc gtg gca cac 1344 Gly Glu Pro Leu Ile Ile Sle er Asp Ile Lys Lys Gly Ser Val Ala His 435 440 445 agg acg ggc acc ctg gag cca ggc gac aag cta ctg gcc att gac aat 1392 Arg Thr Gly Thr Leu Glu Pro Gly Asp Lys Leu Leu Ala Ile Asp Asn 450 455 460 atc cgc ctg gac aac tgc ccc atg gag gac gcc gtg caa atc ctg cgg 1440 Ile Arg Leu Asp Asn Cys Pro Met Glu Asp Ala Val Gln Ile Leu Arg 465 470 475 480 cag tgc gag gac ctg gtg aag cag gag atg gac aac 1488 Gln Cys Glu Asp Leu Val Lys Leu Lys Ile Arg Lys Asp Glu Asp Asn 485 490 495 tct gat gag ctg gag acc aca ggt gcc gtc agc tac aca gtg gag ctg 1536 Ser Asp Glu Leu Glu Thr Gly Ala Val Tyr Thr Val Glu Leu 500 505 510 aag cgc tac ggg ggt ccc ctg ggc atc acc att tcg ggc acg gag gaa 1584 Lys Arg Tyr Gly Gly Pro Leu Gly Ile Thr Ile Ser Gly Thr Glu Glu 515 520 525 cct ttt gc ccc att gt atc tca ggc ctc acc aag cgt ggc ctg gct 1632 Pro Phe Asp Pro Ile Val Ile Ser Gly Leu Thr Lys Arg Gly Leu Ala 530 535 540 gag agg act ggt gcc atc cac gtg ggg gac cgc att ctg gcc atc aac 1680 Glu Ar g Thr Gly Ala Ile His Val Gly Asp Arg Ile Leu Ala Ile Asn 545 550 555 560 aac gtt agc ctc aag ggc cgg ccg ctg agc gag gcc atc cac ctc ctg 1728 Asn Val Ser Leu Lys Gly Arg Pro Leu Ser Glu Ala Ile Leu Leu 565 570 575 cag gtg gct gga gag acc gtc aca ctg aag atc aag aag caa cta gac 1776 Gln Val Ala Gly Glu Thr Val Thr Leu Lys Ile Lys Lys Gln Leu Asp 580 585 590 cgt ccc ctc cta ccc cgc ag tag agc ctc agt gag acc agt gat 1824 Arg Pro Leu Leu Pro Arg Lys Ser Gly Ser Leu Ser Glu Thr Ser Asp 595 600 605 gct gat gag gac cca gca gat gcc ctg aaa gga ggc ctg cca gca gcc 1872 Ala Asp Glu Asp Pro Ala Asp Ala Leu Lys Gly Gly Leu Pro Ala Ala 610 615 620 cgc ttc tcg ccg gct gtg ccc agt gtg gac agt gct gtg gag tct tgg 1920 Arg Phe Ser Pro Ala Val Pro Ser Val Asp Ser Ala Val Glu Ser Trp 625 630 635 640 gac agc tcg gcc acc gag ggt ggc ttt ggg ggc cca ggg tcc tat aca 1968 Asp Ser Ser Ala Thr Glu Gly Gly Phe Gly Gly Pro Gly Ser Tyr Thr 645 650 655 cca cag gca gca gcc cgg ggc acg acc ccc cag gag cgg agg cct ggc 2016 Pro Gln Ala Ala Ala Arg Gly Thr Thr Pro Gln Glu Arg Arg Pro Gly 660 665 670 tgg ctg agg ggc agc ccc cca ccc acc gag ccc cgg agg acg agc tat 2064 Trp Leu Arg Gly Ser Pro Pro Pro Thr Glu Pro Arg Arg Thr Ser Tyr 675 680 685 acc cca acc cca gct gac gag agc ttt cca gag gag gag gag ggg gat 2112 Thr Pro Thr Pro Ala Asp Glu Ser Phe Pro Glu Glu Glu Glu Gly Asp 690 695 700 gat tgg gag ccg cca acg agc cca gcc cct ggc cct gcc cga gag gag 2160 Asp Trp Glu Pro Pro Thr Ser Pro Ala Pro Gly Pro Ala Arg Glu Glu 705 710 715 720 ggc ttc tgg cgc atg ttt gga gaa gct ctc gaa gac ctg gag tcagt Phe Trp Arg Met Phe Gly Glu Alu Leu Glu Asp Leu Glu Ser Cys 725 730 735 ggt cag tca gag ctg ctg agg gaa ctg gag gca tcc atc atg acg ggc 2256 Gly Gln Ser Glu Leu Leu Arg Glu Leu Glu Ala Ser I Gly 740 745 750 acc gtg cag agg gtg gcc ctc gag ggc agg cct ggc cac cgg cct tgg 2304 Thr Val Gln Arg Val Ala Leu Glu Gly Arg Pro Gly His Arg Pro Trp 755 760 765 cag agg ggc cgg gag gta cga gcc tct cct gca gaa atg gag gag ctg 2352 Gln Arg Gly Arg Glu Val Arg Ala Ser Pro Ala Glu Met Glu Glu Leu 770 775 780 ttg ctg cct aca ccc ttg gag atg cac aag gtg acc ctg cac aag gac 2400 Leu Leu Leu Glu Met His Lys Val Thr Leu His Lys Asp 785 790 795 800 ccc atg cgg cat gac ttt ggt ttc agc gtc tca gat ggc ctc ctg gaa 2448 Pro Met Arg His Asp Phe Gly Phe Ser Val Ser Asp Gly Leu Leu Glu 805 810 815 aaa aaa ggt gtc tat gtc cac act gtg cgc cct gat ggg cca gcc cac cgt 2496 Lys Gly Val Tyr Val His Thr Val Arg Pro Asp Gly Pro Ala His Arg 820 825 830 gga ggc ctc cag ccc ttc gac agg gtc ctg cag gtg ctg cag cac gtc cgt 2544 Gly Gly Leu Gln Pro Phe Asp Arg Val Leu Gln Val Asn His Val Arg 835 840 845 aca cgg gac ttc gac tgc tgc ctg gcg gtg cca ctc ctg gcc gag gcg 2592 Thr Arg Asp Phe Asp Val Cys Pro Leu Leu Ala Glu Ala 850 855 860 ggt gat gtc ttg gag ctg atc atc agc cgc aag ccg cac acg gca cac 2640 Gly Asp Val Leu Glu Leu Ile Ile Ser Arg Lys Pro His Thr Ala His 865 870 875 875 agc agcc gg gcc ccc cga tcg cca ggc ccc agc agt ccc cgg atg ctc 2688 Ser Ser Arg Ala Pro Arg Ser Pro Gly Pro Ser Ser Pro Arg Met Leu 885 890 895 tgaagtcagc atgtgggccg aactcctaag gggccaccca ggcagatcct ggctcccaga 2748 cacgtagctg ggctggagaa gcggccaccc actcattcat ctgttggtct ggcagactct 2808 gagcctggga tgatgcttgg tctctgttcc ccaggtctgt ggtgactggg gtgccaggca 2868 gggaggtcct gccctagttg gagtgacagc tggggtctct cgccaagttg ggtctccaag 2928 atgcccagag gagcctccct taagaagggt tggcacaggc tgctcagccg agaggagaga 2988 ggcctggggg ctgtcccagg tctctgtggg gcctccttgg agaggtcgaa gatgtaggga 3048 gcacttcctc ccagcaaagc catggagctg gaatgagctg caaggaggag tgagttctcg 3108 gtcacaggag gtgagcaggc aggagctgga taccccagcg cagtcatgca ttggggtatg 3168 aggcattccc atgatgcgtg cacacgcgct tgggggttgg cttcctgatg gggagccact 3228 tcatctagag actcggccac caggaaggat gctgcttcgg atgggagccc agctccttcg 3288 cttctccaga ataggggttt ggggcttgct agtcctgaga ttctgagatt cccagaatct 3348 ggtccccact tatgagactc ttaagttggg gcgtctggga tcccaggaag tgctggccct 3408 tt agtgggtga ttctttgatt tcagcatctc agtctgaagc ttctgggact 3468 tgagactgtg gttctgggcc cattgggcag gctctatggg ccttgggctc tcagccctcc 3528 tgcttcttct gtaggccgtg tggccactga cccatctgca cgtccgctca gcccaagccc 3588 ctccatgtgg gaggggtcat tttggggcaa aagaccctgg agcttccatt cacctgccat 3648 ccagtgaaaa ttgaaaagcg atggacgcag gacctgtgag gcggtagcgc tcctctttac 3708 agccagatca gtggaggaag aggagaaaga gggagggaga tgggagagaa atgggccaga 3768 gaaaaagatg ggacactctt gcccagtgga gggtgtccaa agtgcttatt caaagaagtc 3828 tattcccact tgaaatctgg aagcaccagc atcccttaaa atcattgtcc tcagtgtcca 3888 caaatcagag accctcttca ttttgagaag ggtgtgggcc tcccctggtg gtctagtgag 3948 tggtgcctgg gatggagtgg gcgggcaggt gtagccaggg ctggggatgt gctttgcctg 4008 gcccagttct cacaggggtc tcaggaaaac ggggcaccca ctcccacctc catctgtctc 4068 caacctgggg tccctggagg ccagaaaagt gctcttccat ttgagggaac agatgaggag 4128 tcaagaggtc tgttcttttc accctgggtc tgttacctgt ttgctgtgtg accctgtctg 4188 ggttggaccc ccagcccctc tggacgatca cgggtggaca gtctgagcag acacaggcct 4248 cctggtcagg gccgga acca tctctgccga cccaccaagg cccccttggg gacctgccca 4308 cgctgtctcc tggaggcctg cctcccttac ccctcccctc cacttcgctg ggctctgccc 4368 cttggtgccc tccctgaggg ccctgcatgc ttgtgcctgg ggtgctcagc gcctctgcta 4428 tcttggattc ccgtgtactc agcccagagt gaaagggcac tgtctacctg tcacagggca 4488 ccaagtgaaa gccaagagcc ctcacttttg agggtgaggg acagcacagc agaggtgtgg 4548 cttctggatg caagcagcca tagctgtgtg accttggaca ggtggctcag cctctctgga 4608 cctctgctaa gcaacagggc tggacaggac acactctcag ggcctctcgg cttgggaaaa 4668 ctgcattgac tccaggactc caggcgaggg aagatgcacc cgactctaac taataccccc 4728 ctccctcctc gggctgaggc ctctgccatt ctcccaaaag tatgcaatca ggcccgcggt 4788 gggcctccca gccatgccgg cctcctcata tgcaatattt cttctggctt ctcatgggga 4848 tggttcatcc ccgacttgaa atttcctgac acctttcccc agtgagcgcc ctgcctgcct 4908 atgcattttg ggaacagccc ctgtgacatg tccccttcca cctgccctct cccccaaagc 4968 tgtatttttc tctggctgag attagaacac attccttgta aagtattttt ctacatcggg 5028 ttttcttagg gctctcggga agcacaaggg gctgtattgc aaaggccgct tatggtctgt 5088 ttggggccct cgtctaagtc t ttgtcccac caggggttgc agtggcttgg gggtaggtgc 5148 catggggatg attttttaaa ataaaattat ttaaatccac ctagagtaga agtttgcttt 5208 ttaaaaaaat catggattgg caagagtcag cttctgtatg ggtctggtga catctcacct 5268 gcttttgatg attcattaat tcaaaaagtt tgccatttgc ttccatcatc cagcccctgg 5328 gcaacatgaa tcagacagat ttaggtcatg tctgcacatt ctggtggcag gcagacaatc 5388 aacaagtaag caaataaata attatttcaa aaggcatcaa gtgcaacaaa gaaaacaagg 5448 gagtaacggg atagagggac cagggtgagg ggctttagct cacaatatta ggaggggttt 5508 ctctcaagag gcgacatttg caatgagacc tgaagacagg agccagcctc catggagacc 5568 tggaggaaga gtgtctcagg cagcgggcac agctagtgca aaggccctga gataggaacg 5628 agtttgacgg tctcaaggaa gagaaagaag gcctgggagg ggaatggggc tggagactag 5688 gttggaggta gcaggaatca gtcgtgaagg cttgggtagg gggagcaaat ttgattctct 5748 gcgcagcaga aagccagagg caggcagtgg tgcctgcata tggagtctct ttagcccagg 5808 ttgggaaggt agtggcagga gggcagcctc gggtctggct gctgccctgg agtgtccaga 5868 gagtgtctag ggcaggtgag ctacagggtc tgggacccag aggccagggc caggccccac 5928 tggggaggcc acagttctgt gagcag agga agagcttctt tccaggaagc gagtactctg 5988 tcttgggagt ggtgtaggca gggggaaggc caagggaggc agcaggcctt gctctaagcg 6048 ctttgcaaga gcttgctgga tcctcccaag agcctttgga ggtgggctct attcctgtcc 6108 catcattaca gatgaggaaa caggcacaga gaggttgagt aacttgccca aggccacaca 6168 ggtagtaagg gatggaacca gggcttgaac acaagccaca tggccagtac acatagagag 6228 agggagggag gtaggcagag gctgtcagaa agagccagaa aatgggggta gggtggtctt 6288 ctattctaac attgtctata aatgagttac tgagaatttt gtctggttag ttgggcaaag 6348 ggctcaactg actcccgagt ttgtccatcc caaagggtgg ggggcgctgt tggcaggaag 6408 gctgccccaa acatggacct gttgtgaccc cagagagccc ctaactgggt attaatgagc 6468 gcctgcacct gacggtgggg gagtgggaga agggcaatca ggtttgctcc ccctctaccc 6528 tttcccccac tccgccaccc gctttctgcc cttctggcag gtcagcccaa ggctaaagag 6588 gagggactga aagccgcagc aggtgagcac ctaaggccaa gagcatcacc tccaatcatc 6648 ctggtggcct tgatggggac aatggtttat tccagatggg gaaactgagg ctcaggtgac 6708 tgctgccaga tctcccagct gtacagggct gggcatgtag caggtagaat cagtagagcc 6768 agtagagcca agagctcatg ggcccgggtg c gaatccagg ttctttcatg gacttgctgt 6828 gtacccctga gtgagcaagc tgcttcctct gtgagcctcc atgtgggaac ctctaacctg 6888 ggaaaatacc tacctttgag gagcgtcctg ggattggacg ggaagccctt tataaaatgt 6948 aaagcgtttg gcaaacgttg agggggaaat acctcaccag aacacaaccc acacatgttg 7008 gatgttaaaa aggaaatgtt tattttcatg ttataaggtg attacaaact cctctaaaaa 7068 aagcaaagat gaatttaaaa tattgatata catatttatc taaaaagcaa aagagaaaaa 7128 aacccctgca aaatacaggg aatcatatca taaaacattt atacacaaaa gcttgtatac 7188 tgcaagactg aactacacac caaggatctt gttcaaatac aaatgttcct cctcag 7244 <210> 196 <211> 2893 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (176) .. (1438) <400> 196 gtttgtcaca gtggactccc tgtggcggga agggaagaac ttttgcacag acaaggcttc 60 agctctagga accccactga caacttgaat ctcaacctct aacctagtgt gaggttcttc 120 ctgtgcccac cttttctgcc ttttgagaag agaaactctt ctcctggcca tctag agc 178 Ser 1 cca gga agc ccc aag ctg ggg ccc tgg tcc cag cat gtc agt cct ctc 226 Pro Gly Ser Pro Lys Leu Gly Pro Trp Ser Gln His Val Ser Pro Leu 5 10 15 ttg tgc ata ggg ctc tgc cct ccc cct gtc agc atg gct gag ctc aga 274 Leu Cys Ile Gly Leu Cys Pro Pro Pro Val Ser Met Ala Glu Leu Arg 20 25 30 cag gtt cca gga ggg cgg gag acc cca cag ggg gag ctg cgg cct gaa 322 Gln Val Pro Gly Gly Arg Glu Thr Pro Gln Gly Glu Leu Arg Pro Glu 35 40 45 gtt gta gag gat gaa gtc cct agg agc cca gtc gca gag cct gga 370 Val Val Glu Asp Glu Val Pro Arg Ser Pro Val Ala Glu Glu Pro Gly 50 55 60 65 gga ggt gga agc agc agc agt gag gcc aaa ttg tcc cca aga gag gag 418 Gly Gly Gly Gly Ser Ser Ser Ser Glu Ala Lys Leu Ser Pro Arg Glu Glu 70 75 80 gaa gaa ctg gat cct aga ata cag gag gag ttg gag cac ctg aac cag 466 Glu Glu Leu Asp Pro Arg Ile Gln Glu Glu Leu Glu His Leu Asn Gln 85 90 95 gcc agc gag gag atc aac cag gtg gaa cta cag ctg gat gag gcc agg 514 Ala Ser Glu Glu Ile Asn Gln Val Glu Leu Gln Leu Asp Glu Ala Arg 100 105 110 acc acc tat cgg agg atc cta cag gag tcg gcg agg aaa ctg aat aca 562 Thr Thr Tyr Arg Arg Ile Leu Gln Glu Ser Ala Arla Lyg Leu Asn Thr 115 120 125 cag ggt tcc cac ttg ggg agc tgc atc gag aaa gcc cgg ccc tac tat 610 Gln Gly Ser His Leu Gly Ser Cys Ile Glu Lys Ala Arg Pro Tyr Tyr 130 135 140 145 gag gct cgg cgg ctg gct aag gag gct cag cag gag aca cag aag gca 658 Glu Ala Arg Arg Leu Ala Lys Glu Ala Gln Gln Glu Thr Gln Lys Ala 150 155 160 gcg ctg cgg tac gag cgg gcc gta agc atg cac aac gct gct cga gaa 706 Ala Leu Arg Tyr Glu Arg Ala Val Ser Met His Asn Ala Ala Arg Glu 165 170 175 atg gtg ttt gtg gct gag cag ggc gtc atg gct gac aag aac cga ctg 754 Met Val Phe Val Ala Glu Gln Gly Val Met Ala Asp Lys Asn Arg Leu 180 185 190 gac ccc acg tgg cag gag atg ctg aac cat gct acct gtg aat 802 Asp Pro Thr Trp Gln Glu Met Leu Asn His Ala Thr Cys Lys Val Asn 195 200 205 gag gcg gag gaa gag cgg ctt cga ggt gag cgg gag cac cag cga gtg 850 Glu Ala Glu Glu Glu Arg Leu Arg Gly Glu Arg Glu His Gln Arg Val 210 215 220 225 act cgg ctg tgc caa cag gct gag gct cgg gtc caa gcc ctg cag aag 898 Thr Arg Leu Cys Gln Gln Ala Glu Ala Arg Val Gln Ala Leu Gln Lys 230 235 240 acc ctc cgg agg gcc atc ggc aag agc cgc ccc tac ttt gag ctc aag 946 Thr Leu Arg Arg Ala Ile Gly Lys Ser Arg Pro Tyr Phe Glu Leu Lys 245 250 255 gcc cag ttc agc cag atc ctg gag gag cac aag gcc aag gtg Aca gaa 994 Ser Gln Ile Leu Glu Glu His Lys Ala Lys Val Thr Glu 260 265 270 ctg gag cag cag gta gct cag gcc aag acg cgc tac tcc gtg gcc ctt 1042 Leu Glu Gln Gln Val Ala Gln Ala Lys Thr Arg Tyr Ser Val Ala Leu 275 280 285 cgt aac ctg gag cag atc agc gag cag att cac gca cgg cgc cgc ggg 1090 Arg Asn Leu Glu Gln Ile Ser Glu Gln Ile His Ala Arg Arg Arg Gly 290 295 300 305 ggt ctg cct ccc cac ccc cgg cgg cgg gc tcc tcc ccc gtg ggg 1138 Gly Leu Pro Pro His Pro Leu Gly Pro Arg Arg Ser Ser Pro Val Gly 310 315 320 gcc gag gca gga ccc gag gac atg gag gac gga gac agc ggg att gag 1186 Ala Glu Ala Gly Pro Glu Asp Met Glu Asp Gly Asp Ser Gly Ile Glu 325 330 335 ggg gcc gag ggt gcg ggg ctg gag gag ggc agc agc ctg ggg ccc ggc 1234 Gly Ala Glu Gly Ala Gly Leu Glu Glu Gly Ser Ser Leu Gly Pro Gly gcc 340 350 c ccc gac acc gat acc ctg agt ctg ctg agc ctg cgc acg gtg 1282 Pro Ala Pro Asp Thr Asp Thr Leu Ser Leu Leu Ser Leu Arg Thr Val 355 360 365 gct tca gac ctg cag aag tgc gac tcc gtg gag cac ttg cga gg 1330 Ala Ser Asp Leu Gln Lys Cys Asp Ser Val Glu His Leu Arg Gly Leu 370 375 380 tcg gac cac gtc agt ctg gac ggc caa gag ctg gga acg cgg agt gga 1378 Ser Asp His Val Ser Leu Asp Gly Gln Glu Leu Gly Thr Arg Ser Gly 390 395 400 ggg cgc cgg ggc agc gac ggc gga gcc cgt ggg ggt cgg cac cag cgc 1426 Gly Arg Arg Gly Ser Asp Gly Gly Ala Arg Gly Gly Arg His Gln Arg 405 410 415 agc gtc agc ctg aggg gccagggttc ctggcttgaa tctgccacca 1478 Ser Val Ser Leu 420 cgggccggtt ggggcccaca gtcttctcac gccctctcct ctggggcctc gtcttcccga 1538 aggtcccctt ctccagtgct tccctgggag aggccagctg tgttcgagtc ctctgtgcct 1598 gccctggcgt tctcacagcc tcccccttcc cctcagcagg cggctctctt tgccttaccc 1658 attcagaagg ctcgccctcg gcgctctgtc tgcctctgcc tgccagctca tcacgatctg 1718 cagggcattg accctttgct ttccctttct gctccctctc tttccatctg tttggctttt 1778 tccctcaggg aacttggtct agaaggcact gggaagctca tcagagaaaa tgggtgctgg 1838 gcctgagtac tcccgtcgga ggggatggac agtcacccct cccgttggtt tccagccccg 1898 ccccccttcc caaggcaact ctggagggta ccctaggtat gctgctgagc cctgcccccc 1958 gtcctgctcc agcctgcccg tgtgtaacct gtaagatgta ctgtgtgcct ccggaagaca 2018 ccacctttcc cttcagcatt ccctttcatg acctgaggca ctctgcgatg tgtgccccaa 2078 agcagaactt acagggcctg caggaagctg gtgtcaggga gagaaaccca accccactgt 2138 caacataggg agcatcacca actccagact ggctcctgtg ggtatggtgt ttccgctggg 2198 ctgggtcctc aacattgcca aggtgctagt gggtccctaa gagggcccat gttgggggtg 2258 aagtcatgag gt cctgaagg cttaggcccc tgtcattccc accctcactc ttgctgcaca 2318 gttgtgttta ctttttctgg gtagaggatg ctgaactgac tcagcaccct cctgcaggac 2378 ggggttaggg aatttggtgc tcaattgctc tcccttgctc ttccccaaac tgaaaatacc 2438 tactgcagga tccctcgggg cacactgaag cttggctgcc aaccctctta cttcctttgt 2498 tacagggagg ggttggcttg gggtgaaaag ttctgccctc cgcagggagc agctccagct 2558 gcctggcagt gctcccagtt tgtagggaag ccacaccaga tctgggtgcc ttgggagaac 2618 cagtccttcc ttttgaccca ccccaggaag atggagtgct cttttctagg cccatgttct 2678 gccagcaacc gggatgcgtg ggcaactgga ctctgcacgg gggtctacag gttgagggag 2738 gttggtcaca atgagaacct cggggtttga ggtggccatg ggcagacagc cgaaagggag 2798 ggagggtgtg ggtgtgcgtg tgtgcatgat aggctgattagttaggtagttaggtagttaggtattg <210> 197 <211> 8047 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3452) <400> 197 tg atg gcg gcg gcg ctg ggg ccc cca gaa gtg atc gct cag ctg gag 47 Met Ala Ala Ala Leu Gly Pro Pro Glu Val Ile Ala Gln Leu Glu 1 5 10 15 aac gcg gct aaa gtt ctg atg gca cac tcc atg gtc aat aat gaa 95 Asn Ala Ala Lys Val Leu Met Ala Pro Pro Ser Met Val Asn Asn Glu 20 25 30 caa cgc cag cat gca gag cac ata ttc tta tca ttt agg aaa tca aaa 143 Gln Arg Gln His Ala Glu His Ile Phe Leu Ser Phe Arg Lys Ser Lys 35 40 45 tca cca ttt gca gtt tgc aag cat att ttg gaa act agt aaa gtg gac 191 Ser Pro Phe Ala Val Cys Lys His Ile Leu Glu Thr Ser Lys Val Asp 50 55 60 tat gtc ctc ttt caa gct gcc aca gcc ata atg gaa gca gtt gtc cga 239 Tyr Val Leu Phe Gln Ala Ala Thr Ala Ile Met Glu Ala Val Val Arg 65 70 75 gag tgg att ctc ttg gaa aaa ggt agc atc gag tct ctg cga 287 Glu Trp Ile Leu Leu Glu Lys Gly Ser Ile Glu Ser Leu Arg Thr Phe 80 85 90 95 ctt tta acc tat gtc tta caa agg ccc aac ctt caa aag tat gtt cgg 335 Leu Leu Thr Tyr Val Leu Gln Arg Pro Asn Leu Gln Lys Tyr Val Arg 100 105 110 ga a cag att cta cta gca gta gca gta att gta aaa aga gga tca tta 383 Glu Gln Ile Leu Leu Ala Val Ala Val Ile Val Lys Arg Gly Ser Leu 115 120 125 gat aaa tca att gac tgc aaa agc att ttt cat gaa gtc agc cag ttg 431 Asp Lys Ser Ile Asp Cys Lys Ser Ile Phe His Glu Val Ser Gln Leu 130 135 140 att agt agt ggc aat ccc act gtg caa act ctg gcc tgt tct att ctg 479 Ile Ser Ser Gly Asn Pro Thr Val Gln Thr Leu Ala Cys Ser Ile Leu 145 150 155 act gcg cta ttg agt gaa ttt tca agt tca agt aaa act agc aac att 527 Thr Ala Leu Leu Seru Glu Phe Ser Ser Ser Ser Lys Thr Ser Asn Ile 160 165 170 175 gga ttg agc atg gaa ttc cat ggt aac tgc aaa aga gtt ttt cag gaa 575 Gly Leu Ser Met Glu Phe His Gly Asn Cys Lys Arg Val Phe Gln Glu 180 185 190 gaa gac ctt cgt cag atc ttc atg tta act gtt gaa gtt ctg cag gag 623 Glu Leu Arg Gln Ile Phe Met Leu Thr Val Glu Val Leu Gln Glu 195 200 205 ttc agc agg cgg gaa aac ctc aat gct cag atg tct tca gta ttt cag 671 Phe Ser Arg Arg Glu Asn Leu Asn Ala Gln Met Ser Ser Val Phe Gln twenty one 0 215 220 cgt tac ctt gca ctc gcc aat caa gtc ttg agc tgg aac ttt ctt cct 719 Arg Tyr Leu Ala Leu Ala Asn Gln Val Leu Ser Trp Asn Phe Leu Pro 225 230 235 cca aat ttg ggc aga cat tat ata gct atg gaa tcc tcg caa aat 767 Pro Asn Leu Gly Arg His Tyr Ile Ala Met Phe Glu Ser Ser Gln Asn 240 245 250 255 gtg ctg ttg aag cca aca gag tcc tgg cgg gag act ctt ctg gac agc 815 Val Leu Leu Lys Pro Thr Glu Ser Trp Arg Glu Thr Leu Leu Asp Ser 260 265 270 aga gtt atg gag ctt ttc ttc aca gta cat cga aaa atc aga gaa gat 863 Arg Val Met Glu Leu Phe Phe Thr Val His Arg Lys Ile Arg Glu Asp 275 280 280 tca gat atg gca caa gat tct ctg cag tgc ctt gcc cag tta gct tct 911 Ser Asp Met Ala Gln Asp Ser Leu Gln Cys Leu Ala Gln Leu Ala Ser 290 295 300 ctt cat gga ccc atc ttc cca gat gaa gga tca caa gtt gat tat 959 Leu His Gly Pro Ile Phe Pro Asp Glu Gly Ser Gln Val Asp Tyr Leu 305 310 315 gca cac ttc att gag gga tta ctg aat act atc aat gga att gaa ata 1007 Ala His Phe Ile Glu Gly Leu Leu Asn Thr Ile Asn Gly I le Glu Ile 320 325 330 335 gaa gat tct gaa gct gtg ggg atc atc tcc agc att atc agc aac ctg ata 1055 Glu Asp Ser Glu Ala Val Gly Ile Ser Ser Ile Ile Ser Asn Leu Ile 340 345 350 acc gtg ttc cca cga aat tta act gcc att cca agt gaa ctt ttc 1103 Thr Val Phe Pro Arg Asn Val Leu Thr Ala Ile Pro Ser Glu Leu Phe 355 360 365 tcc tcc ttt gtt aac tgc ctc aca cac ctc act tgt tct ttt ggg cga 1151 Ser Ser Phe Val Asn Cys Leu Thr His Leu Thr Cys Ser Phe Gly Arg 370 375 380 agt gct gca ttg gaa gaa gtg ctt gat aaa gat gac atg gta tac atg 1199 Ser Ala Ala Ala Leu Glu Glu Val Leu Asp Lys Asp Asp Met Val Tyr Met 385 390 395 gaa gca tat gat aaa ttg ttg gag tcc tgg tta act ttg gtt caa gat 1247 Glu Ala Tyr Asp Lys Leu Leu Glu Ser Trp Leu Thr Leu Val Gln Asp 400 405 410 415 gac aaa cat ttc cat aaa ggc ttt ttt acc caa cat gca gtt caa gtt 1295 Asp Lys His Phe His Lys Gly Phe Phe Thr Gln His Ala Val Gln Val 420 425 430 ttc aat tcc tat att cag tgc cac cta gct gct cca gat ggc aca aga 1343 Phe Asn Ser Tyr Ile Gln Cys H is Leu Ala Ala Pro Asp Gly Thr Arg 435 440 445 aat ttg act gcc aat ggt gtg gcc tct cgt gag gag gaa gaa ata agt 1391 Asn Leu Thr Ala Asn Gly Val Ala Ser Arg Glu Glu Glu Glu Ile Ser 450 455 460 gaa ctt caa gag gat gat cga gac cag ttt tct gat caa ctg gcc agt 1439 Glu Leu Gln Glu Asp Asp Arg Asp Gln Phe Ser Asp Gln Leu Ala Ser 465 470 475 gta gga atg cta gga aga att gct gca gaa cac tgt atc ctt 1487 Val Gly Met Leu Gly Arg Ile Ala Ala Glu His Cys Ile Pro Leu Leu 480 485 490 495 aca agt tta tta gaa gaa aga gta aca aga ctc cat ggt cag tta caa 1535 Thr Ser Leu Leu Glu Glu Arg Val Thr Arg Leu His Gly Gln Leu Gln 500 505 510 cga cat cag caa cag tta ctt gct tca ccg ggt tca agc act gtt gac 1583 Arg His Gln Gln Gln Leu Leu Ala Ser Pro Gly Ser Ser Thr Val Asp 515 520 525 aac aaa atg ctt gat gat ctc tat gaa gat att cac tgg ctt att tta 1631 Asn Lys Met Leu Asp Asp Leu Tyr Glu Asp Ile His Trp Leu Ile Leu 530 535 540 gtt aca ggc tac ctc tta gct gat gat act cag gga gag act ccg cta 1679 Val Thr Gl y Tyr Leu Leu Ala Asp Asp Thr Gln Gly Glu Thr Pro Leu 545 550 555 ata cct cca gaa ata atg gaa tat tcc att aag cat tca tct gaa gtt 1727 Ile Pro Pro Glu Ile Met Glu Tyr Ser Ile Lys His Ser Ser Glu Val 560 565 570 575 gac att aat aca aca ctt caa att ttg gga tct cca gga gaa aag gct 1775 Asp Ile Asn Thr Thr Leu Gln Ile Leu Gly Ser Pro Gly Glu Lys Ala 580 585 590 590 tct tcc atc cca ggg tac aac aga acaat tct gtg att agg ctg ttg 1823 Ser Ser Ile Pro Gly Tyr Asn Arg Thr Asp Ser Val Ile Arg Leu Leu 595 600 605 tct gcc att ctc aga gtt tca gaa gtt gaa tct cga gca ata aga gca 1871 Ser Ala Ile Leu Arg Val Ser Glu Val Glu Ser Arg Ala Ile Arg Ala 610 615 620 gat ctc act cat cta cta agt ccc cag atg ggc aaa gat att gtt tgg 1919 Asp Leu Thr His Leu Leu Ser Pro Gln Met Gly Lys Asp Ile Val Trp 625 630 630 tttt tta aaa cgc tgg gca aag act tat ctc ctg gtg gat gaa aaa ctg 1967 Phe Leu Lys Arg Trp Ala Lys Thr Tyr Leu Leu Val Asp Glu Lys Leu 640 645 650 650 655 tat gat cag ata agt ctg cca ttc agt gcagcg gat aca 2015 Tyr Asp Gln Ile Ser Leu Pro Phe Ser Thr Ala Phe Gly Ala Asp Thr 660 665 670 gag ggt tct cag tgg ata att ggc tac ctc tta caa aaa gtc atc agt 2063 Glu Gly Ser Gln Trp Ile Ile Gly Tyr Leu Leu Gln Lys Val Ile Ser 675 680 685 aac ctc tca gtc tgg agt agt gag cag gac ctt gca aat gac act gtg 2111 Asn Leu Ser Val Trp Ser Ser Glu Gln Asp Leu Ala Asn Asp Thr Val 690 695 700 cag ctc ctt gtc act ttg gtg gaa aga aga gaa agg gca aac tta gta 2159 Gln Leu Leu Val Thr Leu Val Glu Arg Arg Glu Arg Ala Asn Leu Val 705 710 715 att caa tgt gag aac tgg tgg aat tta gct aag cag ttt gca agc cga 2207 Ile Gln Glu Asn Trp Trp Asn Leu Ala Lys Gln Phe Ala Ser Arg 720 725 730 735 agc cca cct ctt aat ttc ttg tca agt cct gtg cag agg aca ttg atg 2255 Ser Pro Pro Leu Asn Phe Leu Ser Ser Pro Val Gln Arg Thr Leu Met 740 745 750 aag gct cta gtc tta gga ggt ttt gca cat atg gac aca gaa acc aaa 2303 Lys Ala Leu Val Leu Gly Gly Phe Ala His Met Asp Thr Glu Thr Lys 755 760 765 cag cag tat tgg aca gag gtt ctt cag c ca ctt cag cag cga ttc tta 2351 Gln Gln Tyr Trp Thr Glu Val Leu Gln Pro Leu Gln Gln Arg Phe Leu 770 775 780 aga gtg ata aac caa gaa aac ttc cag cag atg tgt cag caa gag gaa 2399 Arg Val Ile Gln Asn Phe Gln Gln Met Cys Gln Gln Glu Glu 785 790 795 gtc aag cag gaa atc act gcc aca cta gag gcc ctg tgt ggc att gct 2447 Val Lys Gln Glu Ile Thr Ala Thr Leu Glu Ala Leu Cys Gly Ile Ala 800 805 810 gag gct acc cag att gac aac gta gca atc ctg ttt aat ttt tta atg 2495 Glu Ala Thr Gln Ile Asp Asn Val Ala Ile Leu Phe Asn Phe Leu Met 820 825 830 gac ttc ctt acc aat tgc att gga ttg atg aga gtt aat acc 2543 Asp Phe Leu Thr Asn Cys Ile Gly Leu Met Glu Val Tyr Lys Asn Thr 835 840 845 cca gag act gtc aat ctc att ata gaa gtt ttt gtt gaa gtt gca cat 2591 Pro Glu Thr Val Val Asn Leu Ile Ile Glu Val Phe Val Glu Val Ala His 850 855 860 aaa cag ata tgc tat ctt gga gag tcc aaa gct atg aac tta tat gaa 2639 Lys Gln Ile Cys Tyr Leu Gly Glu Ser Lys Ala Met Asn Leu Tyr Glu 865 870 875 875 gcc tgc ctt act t tg ttg caa gtg tat tct aag aat aat tta ggg cgg 2687 Ala Cys Leu Thr Leu Leu Gln Val Tyr Ser Lys Asn Asn Leu Gly Arg 880 885 890 895 caa aga ata gat gtt aca gca gaa gaa gag caa tac caa gacct Gln Arg Ile Asp Val Thr Ala Glu Glu Glu Gln Tyr Gln Asp Leu Leu 900 905 910 ctc att atg gaa ctt ctt act aac ctg ctg tca aaa gaa ttc ata gat 2783 Leu Ile Met Glu Leu Leu Thr Asn Leu Leu Ser Glu Ile Asp 915 920 925 ttc agt gat aca gat gaa gtg ttt aga gga cat gag cca ggt caa gca 2831 Phe Ser Asp Thr Asp Glu Val Phe Arg Gly His Glu Pro Gly Gln Ala 930 935 940 gca aac aga tct gtg tca gca gc g gtt gtg ttg tat gga gta aac 2879 Ala Asn Arg Ser Val Ser Ala Ala Asp Val Val Leu Tyr Gly Val Asn 945 950 955 cta att ctg ccc ttg atg tca cag gat ctc ttg aag ttt cca acc ctt 2927 Leu Ile Leu Pro Leu M Ser Gln Asp Leu Leu Lys Phe Pro Thr Leu 960 965 970 975 tgt aat cag tac tac aaa tta atc aca ttt atc tgt gag att ttt cct 2975 Cys Asn Gln Tyr Tyr Lys Leu Ile Thr Phe Ile Cys Glu Ile Phe Pro 980 98 5 990 gaa aaa ata cca cag ctt cct gag gat ctg ttt aaa agt ctg atg tac 3023 Glu Lys Ile Pro Gln Leu Pro Glu Asp Leu Phe Lys Ser Leu Met Tyr 995 1000 1005 tcc cta gaa tta gga atg aca tca atg agt tg gtt tgc cag ctt 3071 Ser Leu Glu Leu Gly Met Thr Ser Met Ser Ser Glu Val Cys Gln Leu 1010 1015 1020 tgc ctg gag gcc ttg aca ccg tta gct gaa cag tgt gca aaa gca caa 3119 Cys Leu Glu Ala Leu Thr Pro Leu Ala Glu Gln Cys Ala Lys Ala Gln 1025 1030 1035 gaa aca gac tca cca ctt ttt cta gca aca cgg cac ttt ctt aag ctg 3167 Glu Thr Asp Ser Pro Leu Phe Leu Ala Thr Arg His Phe Leu Lys Leu 1040 1045 1050 1055 gtt ttt g atg ctg gtt ttg caa aag cac aac aca gag atg acc act 3215 Val Phe Asp Met Leu Val Leu Gln Lys His Asn Thr Glu Met Thr Thr 1060 1065 1070 gcg gct ggc gaa gct ttc tac acg ttg gtg tgt ttg cac cag gct Ala Ala Gly Glu Ala Phe Tyr Thr Leu Val Cys Leu His Gln Ala Glu 1075 1080 1085 tat tct gaa ctg gtc gaa aca tta cta tca agt cag caa gac cca gtt 3311 Tyr Ser Glu Leu Val Glu Thr Leu L eu Ser Ser Gln Gln Asp Pro Val 1090 1095 1100 att tac cag aga tta gca gat gcc ttc aac aag ctc act gca agc agc 3359 Ile Tyr Gln Arg Leu Ala Asp Ala Phe Asn Lys Leu Thr Ala Ser Ser 1105 1110 1115 act cct cct acg ctg gat cgg aag cag aag atg gcc ttc tta aag agt 3407 Thr Pro Pro Thr Leu Asp Arg Lys Gln Lys Met Ala Phe Leu Lys Ser 1120 1125 1130 1135 tta gaa gaa ttt atg gca aat gtt ggt ggt ctc ctt tgt gta Leu Glu Glu Phe Met Ala Asn Val Gly Gly Leu Leu Cys Val Lys 1140 1145 1150 taaacaacag aactttatgc ttaatttaga tcctttctgc aaagtgcact gaattgctga 3512 aagttgactt gagtcttgtc ctattcctca gttcatttgg ccattttgga ttttggagag 3572 cctgaaactt tgatatgtat gtaatacagt gaaacaggag aggtcaactt ggcatcagct 3632 tctgctgtta agtgttagcc acaatctgtc atatatatgt cttttagatt ctgaatggtg 3692 atttaaaatt ttcaaaatga aattccatat atgtgcaaac agatatgggc accacgaaat 3752 acatatgcag tgcctttttt ccttttaaca taggtggcta gccaaagttt agaatttttg 3812 tcattaaata tgaaatggat atatgctagg cagtgtttct caaaatctcc acagatcgcc 3872 tgcatcactt gagga gctgg tgaaaaggca gattcttagg cccaactgta gaccttcaga 3932 gtcagaatgt ctggttgttg ggcccaggag tcttcatgtt aataagcttc tccctttcgt 3992 caccccaaaa gttttgaatc aatgaaagag acattgaaaa ctcttaagag gttttgtgct 4052 ttctagcttt tcctcccttt gatgattggg ttttataatt cagcaggaag gggaaacatc 4112 accaggggtt tgttggcttt ttcttagctt gctttcttgc ttgcttgctt tcttgctttt 4172 cttgctttct gtctctctct ttcttttctc tctctctctc acatcaaccc agtgctgcag 4232 gttttgtgta atacaagtca ctaatcatac tctgatgcct gaacttgagg aggaaaatac 4292 atgtatattt ttgttccgta aaaataacct taggaactgt agccatttca ttgccttaat 4352 tttaagagga aaatacaaaa acagctgatt tgttttagta agaaaccacg tcttgatgct 4412 tcagagttgg tttagggtgt tagctgctat gaacctgttg cccctttcga tcgtgtattt 4472 atgtaggttt atcagtgaaa tgaaaggctt gtttccgtct agtctaactt tttgagtgtg 4532 tttctatcca gccacatagc ccatatctac tctaaatggc ttgcttaagc aataattatt 4592 ttaaaggatg tgaatcactg attcacacag actattgcac gttggggcat taggggcaat 4652 aattcttatc cagacatggg agccagtgaa tttaatttca gagattaaaa attcacttta 4712 gatcctctag tttgatctct taatcaggat ttttatacag ctgccaggct cccctaattc 4772 agtgtgccag cttacaatgt ggaaatgaaa gctaatttat acacagcagg catatgaaac 4832 tccactcatt gcagtacttt cacagcacag tgacaggtag aggactctgg cacaggtgca 4892 ctcatgaaac tctgcttcca ccatgttcct gacacctatc tattaaacca ttctgcaaat 4952 acggtttttc tacctgattg catatagcat atgtgtcatt acatgtgatg ctgtgcaaaa 5012 ctttgtataa ttctgtgtta ttaacagtta acaaaactgg agcatctgaa ttacatccaa 5072 cctgtgcatg tgatgttagg tagatgtgaa tgcagggcct tgggccataa cttacatttc 5132 tctcaatttg attagctttg agtcacaatt aaggggaagc aaaaacatct tgaaaagact 5192 gctaggaagg aaattaatat cagtcatcca gaagtacacg tttctgtatt ttaaaaaata 5252 ctttgatgca tttattttta ggtgtttttt ttttcccctt aaaaaacttg aagtgatatg 5312 cagcagtaat ctatttgttt tgcattgttc ttggtgtttt gtgtttccca gatccctcaa 5372 gctttctcag ctgttgcgaa ttatgtgtat ctgtgtgtgt gctaagtaca gtctctttac 5432 caaagggcac tgaaacacac aattgactgg acaggtccac gcgccatgac aaaactataa 5492 tcaagttatt aaaactaaag aggagtggga aaggaatgcc ttggtaagta aaaaggcatc 5552 tatatttaat aacttttatc caga tggcaa catatttgca aaatttgccc agatcctatt 5612 acaatactaa aaatagaaaa tttcacctcc atattcctga ggtgtaattt cattagacta 5672 gttttagttt aaaaagacct tcttcagatt ggaccaaata atacttataa gatcagcaga 5732 atgttgaata ttagctcact ggggtgggga gaagccacta ccatttttta ggtgatgggg 5792 atgccactga gttgcaacgg ctagaccttt tcagggtggt tgtgtccatg tttgcctgat 5852 tggatgctta ttcactttgt gttttctttt gttttatttt gtccaatttt gtctttagct 5912 gtgtttatta acttctccgg tcttgttttg ttttaatgct cttggcccag tgggtgtcaa 5972 gaacactggc ttaattcaag tcagttgatt ttttttctat taaaactgtt gttaaaatat 6032 tttttaaaac aaaaacatta tttgtgccct cttttatata tgtcaaaggg acactgtcaa 6092 gtatttcatt tttagatttt tgttttataa aatttctgtt gttcatatag tatcctttaa 6152 cctctagttt tccatacatc ctttgtttgt ttctcatttt attttccttg acccatttat 6212 ttcccaaggc acaatcacta aagactttgt actttcacag tctgttaatg tggtagcacc 6272 tgtaactgtg ttcttgttct gttaaaagga ttgatttgct tttatagtcc ttgtgctgga 6332 tgagtggctg cctcagtagc aaaactacct gacagtattt gacagtgtcc tttccagcac 6392 cattatttgg gtctttcagg gtggccatct ctgttagaag acagtagcat gttaacatca 6452 ctgcattgag tttttgtctg gtgtaaagta tgacttttaa tgtaaacaaa ctgcaggttt 6512 ttttcaaact aattttaaga atttagtctt atttcgttgt aaactgtgta tctaattata 6572 ttacattact ctgttcagat gggatggtta ctaccacttg tccatgattt tcatttgaaa 6632 agcaagtatc tatatcattt ccccccagtc agcattattt aacactcccc ttaactgtct 6692 ttgaactttc tcttttaaca aaaatgtcaa gtctttacag ttgtaatatc accatgtttc 6752 ccatttctgt taatacttct atgaacccct aaagtattga agggaactag ctgtcagttt 6812 caaggattac aagtttgagt ctcctagtat tcaacatcat tctgaaccct gaaataatat 6872 ttttctctgt taaacaattt ttatctgttt gccacctctg ttgttagagg tggttgtcaa 6932 ttgaccttac taagttagct gtctttgatg aggaattatt gttattggtt cctgaataaa 6992 acattaacct tttaagtcag aaggaacctc ggtacttctt aaggtttgtt tgtgttttct 7052 aaaaccagag aataaggaac tgatttggct atgaggttta acattataat tttctgtaag 7112 ctttcccaca aaaaaacatt gttgatttga ggatataata atgttttaat ctttttaaaa 7172 tataagtggt tattctctga cttggtaact atgttctgaa aacactgcat ttaagaattt 7232 ttaaaaattg gttttctaaa attaaaatgt ccaa attagg catattgctg agctcaaatt 7292 gatgtgaaat gccatggttc cagttgaatt ttaagcatat tttcatttag atataaaata 7352 tatgaagtat gctttgttga ttatagtgag aacccatgac atagttaacc aaagaatatg 7412 tttggttcaa ataaaaatag aagcttaata ctgggcattc atacttttta aagagaatga 7472 atgaagaaat cggtttcctg ctgtagttct ctatgggtaa gtcttagtaa agacgagaat 7532 gctgaagtcg gccgtggcga ttccctccta ggaactggga ggtgtggctt gcccattacc 7592 cgcttgaagc tcacatcttt accctcctct cccactgtgg tttgatcttc acctattccc 7652 aggccctccc agcaattgga gaggtgtctt tttttttggt tttggttttt tttctccccg 7712 tctgcattct taggcctctt agctattagg aactgtcaga tacatactag tagctaattt 7772 tcctagcctg aaattatata ctgcatctgc actatgtacc tactagggat ctgacctcaa 7832 gtgttttctg agcccaggct tcctggtgtg gtgtctttta ccacataaaa ttattacaaa 7892 ttgcaaatgt tggtattgtg atttgattat ctgtacaaag aaagaagctc tatgcagtga 7952 gtttgtggtt taatggtcac aaaaatgtta gcactgctac cactcagcac gtgtaaaatt 8012 ttttaaattt ataaatatta aaattttaaa cttac 8047 <210> 198 <211> 7858 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (173) .. (4663) <400> 198 atgagaggtg gtgaacagtg accatactgg tatacaacac tatgggacct ggcatttttg 60 ctgcatgtcc agcccacccc cactaataat gtaggaagct gtctggtcca ttggaaacac 120 taatctgatc tcagaagtgg ctgatcgtgg caggatgtgt cgacgatgat ga tgg caa 178 Trp Gln 1 gaa agc aag atg tcc gaa ttc cca cct aca aca tca gtg tgg tgg gat 226 Glu Ser Lys Met Ser Glu Phe Pro Pro Thr Thr Ser Val Trp Trp Asp 5 10 15 tat ctg gga ccg aga agg aaa agg gcc agt gtg gga ttg gaa agt ctt 274 Tyr Leu Gly Pro Arg Arg Lys Arg Ala Ser Val Gly Leu Glu Ser Leu 20 25 30 gtt tgt gca acc gct tcg tgc gcc cga gtg ctg acg agt ttt cac ttg 322 Val Cys Ala Thr Ala Ser Cys Ala Arg Val Leu Thr Ser Phe His Leu 35 40 45 50 gac cat acc tcc gtc ctc agc acc agt gac ttt gga ggg cga gtg gtc 370 Asp His Thr Ser Val Leu Ser Thr Ser Asp Phe Gly Gly Arg Val Val 55 60 65 aat aat gac cac ttt ctc tac tgg gga gaa gtt agc cgc tcc ctg gag 418 Asn Asn Asp Asp His Phe Leu Tyr Trp Gly Glu Val Ser Arg Ser Leu Glu 70 75 80 gat tgt gtg gaa tgt aag atg cac att gtg gag cag act gaa ttt att 466 Asp Cys Val Glu Cys Lys Met His Ile Val Glu Gln Thr Glu Phe Ile 85 90 95 gat gat cag act ttt caa cct cat cga agc acg gcc ctg cag ccc tat 514 Asp Asp Gln Thr Phe Gln Pro His Arg Ser Thr Ala Leu Gln Pro Tyr 100 105 110 atc aag aga gct gct gcg acc aag ctt gca tca gct gaa aaa ctc atg 562 Ile Lys Arg Ala Ala Ala Thr Lys Leu Ala Ser Ala Glu Lys Leu Met 115 120 125 130 tac ttt tgc act gac cag ctg ggg ctg gag cag gac ttt gag cag aaa 610 Tyr Phe Cys Thr Asp Gln Leu Gly Leu Glu Gln Asp Phe Glu Gln Lys 135 140 145 caa atg cca gac gga aag ctg ctg gtt gat ggt ttt ctt ctt ggt att 658 Gln Met Prot Gly Lys Leu Leu Val Asp Gly Phe Leu Leu Gly Ile 150 155 160 gat gtt agc agg ggc atg aat agg aac ttt gat gac cag ctc aag ttt 706 Asp Val Ser Arg Gly Met Asn Arg Asn Phe Asp Asp Gln Leu Lys Phe 165 170 175 gtc tcc aat ctc tac aat cag ctt gca aaa aca aaa aag ccc ata gtg 754 Val Ser Asn Leu Tyr Asn Gln Leu Ala Lys Thr Lys Lys Pro Ile Val 180 185 190 gtg gtc ctg act aag tgt gac gaa ggt gtt gag tgg a tt aga gat 802 Val Val Leu Thr Lys Cys Asp Glu Gly Val Glu Arg Tyr Ile Arg Asp 195 200 205 210 gca cat act ttt gcc tta agc aaa aag aac ctc cag gtt gtg gag acc 850 Ala His Thr Phe Ala Leu Ser Lys Lys Asn Leu Gln Val Val Glu Thr 215 220 225 tca gcg aga tcc aat gta aac gtg gac ttg gct ttc agc acc tta gtg 898 Ser Ala Arg Ser Asn Val Asn Val Asp Leu Ala Phe Ser Thr Leu Val 230 235 240 caa ctc att gat aaa agt cgg gga aag aca aaa atc att cct tat ttt 946 Gln Leu Ile Asp Lys Ser Arg Gly Lys Thr Lys Ile Ile Pro Tyr Phe 245 250 255 gaa gct ctc aag cag cag agt cag cag ata gct aca gca aaa gac aag 994 Glu Ala Leu Lys Gln Gln Ser Gln Gln Ile Ala Thr Ala Lys Asp Lys 260 265 270 tat gag tgg ctg gtg agt cgc att gtg aaa aac cac aat gag aac tgg 1042 Tyr Glu Trp Leu Val Ser Arg Ile Val Lys Asn His Asn Glu Asn Trp 275 280 285 285 290 ctg agt gtc agc cga aag atg cag gcc tct cca gaa tac cag gac tat 1090 Leu Ser Val Ser Arg Lys Met Gln Ala Ser Pro Glu Tyr Gln Asp Tyr 295 300 305 gtc tac ctg gaa ggg act cag aag aag ctg ttt cta cag cac 1138 Val Tyr Leu Glu Gly Thr Gln Lys Ala Lys Lys Leu Phe Leu Gln His 310 315 320 atc cac cgc ctc aag cat gag cat atc gag cgt agg aga aag ctg tac 1186 Ile His Arg Leu Lys His Glu His Ile Glu Arg Arg Arg Lys Leu Tyr 325 330 335 ctg gca gcc ctg cca tta gct ttt gaa gct ctt ata cct aat cta gat 1234 Leu Ala Ala Leu Pro Leu Ala Phe Glu Ala Leu Ile Pro Asn Leu Asp 340 345 350 ata gac cac cta agc tgc ata aaa gcc aaa aag ctc tta gaa acc 1282 Glu Ile Asp His Leu Ser Cys Ile Lys Ala Lys Lys Leu Leu Glu Thr 355 360 365 365 370 aag cca gaa ttc ttg aag tgg ttt gtt gtg acctga cca tgg 1330 Lys Pro Glu Phe Leu Lys Trp Phe Val Val Leu Glu Glu Thr Pro Trp 375 380 385 gat gcc acc agt cac att gac aac atg gaa aac gaa cgg att ccc ttt 1378 Asp Ala Thr Ser His Ile Asp Asn Met Glu Asn Glu Arg Ile Pro Phe 390 395 400 gat tta atg gat acc gtc cct gca gag cag cta tac gag gcc cac tta 1426 Asp Leu Met Asp Thr Val Pro Ala Glu Gln Leu Tyr Glu Ala His Leu 405 410 415 gag aag ctg agg aac gaa agg aaa aga gtt gag atg cga agg gcg ttt 1474 Glu Lys Leu Arg Asn Glu Arg Lys Arg Val Glu Met Arg Arg Ala Phe 420 425 430 aaa gaa aac ctg gag act tct cct ttc ata act ccc gga aag cct tgg Glu Asn Leu Glu Thr Ser Pro Phe Ile Thr Pro Gly Lys Pro Trp 435 440 445 450 gaa gag gcc cgt agt ttt att atg aat gag gat ttc tac cag tgg ctg 1570 Glu Glu Ala Arg Ser Phe Ile Met Asn Glu Asp Phe Tyr Gln Trp Leu 455 460 465 gag gaa tct gta tac atg gat att tat ggc aaa cac caa aag caa att 1618 Glu Glu Ser Val Tyr Met Asp Ile Tyr Gly Lys His Gln Lys Gln Ile 470 475 480 ata gat aaa gca aag gaa gaa gag ttg ctt ttg gaa tat tca 1666 Ile Asp Lys Ala Lys Glu Glu Phe Gln Glu Leu Leu Leu Glu Tyr Ser 485 490 495 gaa ttg ttt tat gaa ctg gag ctg gat gct aag ccc agc aag gag Leuaglu Glu Leu Asp Ala Lys Pro Ser Lys Glu Lys 500 505 510 atg ggt gtt att cag gat gtt ctg gga gag gaa cag cga ttt aaa gca 1762 Met Gly Val Ile Gln Asp Val Leu Gly Glu Glu Gln Arg Phe Lys Ala 515 520 5 25 530 tta caa aag ctc caa gca gag cgt gat gcc ctt att ctg aaa cac att 1810 Leu Gln Lys Leu Gln Ala Glu Arg Asp Ala Leu Ile Leu Lys His Ile 535 540 545 cat ttt gtg tac cac cca aca ac gag aca tac agc tgc cca gct 1858 His Phe Val Tyr His Pro Thr Lys Glu Thr Cys Pro Ser Cys Pro Ala 550 555 560 tgt gtg gac gct aag att gag cac ttg att agt tct cgg ttt atc cgg 1906 Cys Val Asp Ala Lys Ile Glu His Leu Ile Ser Ser Arg Phe Ile Arg 565 570 575 ccg tct gac cgg aat cag aaa aat tca ctc tct gac cct aac att gat 1954 Pro Ser Asp Arg Asn Gln Lys Asn Ser Leu Ser Asp Pro Asn Ile Asp 580 585 590 590 aga atc aac ttg gtt ata ttg ggc aaa gac ggc ctt gcc cga gag ttg 2002 Arg Ile Asn Leu Val Ile Leu Gly Lys Asp Gly Leu Ala Arg Glu Leu 595 600 605 610 gcc aat gag att cga gct ctt tgt aca aat gat gac atag tat gt Ala Asn Glu Ile Arg Ala Leu Cys Thr Asn Asp Asp Lys Tyr Val Ile 615 620 625 gat ggt aaa atg tat gag ctt tcc ctg agg cca ata gag ggg aat gtc 2098 Asp Gly Lys Met Tyr Glu Leu Ser Leu Arg Pro Ile G lu Gly Asn Val 630 635 640 agg ctt cct gtg aac tct ttc cag acg cca aca ttt cag ccc cac ggc 2146 Arg Leu Pro Val Asn Ser Phe Gln Thr Pro Thr Phe Gln Pro His Gly 645 650 655 tgt ctc tgc ctt tac aat tca aag gaa tcg cta tcc tat gta gtg gaa 2194 Cys Leu Cys Leu Tyr Asn Ser Lys Glu Ser Leu Ser Tyr Val Val Glu 660 665 670 agt ata gag aag agt aga gag tcc acg ctg ggc cgg cgg gat aat cat 2242 Ser Ile Glu Ser Arg Glu Ser Thr Leu Gly Arg Arg Asp Asn His 675 680 685 690 tta gtc cat ctc ccc ctt aca tta att ttg gtt aac aag aga gga gac 2290 Leu Val His Leu Pro Leu Thrhr Leu Ile Leu Val Asn Lys Arg Gly Asp 695 700 705 acc agt gga gag act ctg cat agc tta ata cag caa ggt caa caa att 2338 Thr Ser Gly Glu Thr Leu His Ser Leu Ile Gln Gln Gly Gln Gln Ile 710 715 720 gct agc aaa ctt cag tgt gtc ttt ctc gac cct gct tct gct ggc att 2386 Ala Ser Lys Leu Gln Cys Val Phe Leu Asp Pro Ala Ser Ala Gly Ile 725 730 735 ggt tac gga cgc aac att aat gaa aag caa atc agt caa gtt ttg aag 2434 Gly Tyr Gly Arg Asn Ile Asn Gl u Lys Gln Ile Ser Gln Val Leu Lys 740 745 750 gga ctc ctg gac tct aag cgt aac tta aac ctg gtc agt tct act gct 2482 Gly Leu Leu Asp Ser Lys Arg Asn Leu Asn Leu Val Ser Ser Thr Ala 755 760 760 765 agc atc aaa gat ttg gct gat gtt gat ctg cga att gtt atg tgt ctg 2530 Ser Ile Lys Asp Leu Ala Asp Val Asp Leu Arg Ile Val Met Cys Leu 775 780 785 atg tgt gga gat cct ttt agt gca gat gac ata ctt ttt ctt ctt 2578 Met Cys Gly Asp Pro Phe Ser Ala Asp Asp Ile Leu Phe Pro Val Leu 790 795 800 cag tcc caa acc tgt aaa tct tcc cat tgt gga agc aac aac tct gtt 2626 Gln Ser Gln Thr Cys Lys Ser Ser His Cys Gly Ser Asn Asn Ser Val 805 810 815 tta ctt gaa cta cca atc gga ctg cac aag aag cgg att gaa ctg tct 2674 Leu Leu Glu Leu Pro Ile Gly Leu His Lys Lys Arg Ile Glu Leu Ser 820 825 830 830 gtt ctt tca tac cat tcc tcc ttt agc atc aga aag agc cgg ttg gtt 2722 Val Leu Ser Tyr His Ser Ser Phe Ser Ile Arg Lys Ser Arg Leu Val 835 840 845 850 cat ggg tac att gtt ttt tat tca gcc aaa cgt aag gcc tct ttg gct 2770 His Gly Tyr Ile Val Phe Tyr Ser Ala Lys Arg Lys Ala Ser Leu Ala 855 860 865 atg tta cgt gcc ttt ctt tgt gaa gtg cag gat att atc cct att cag 2818 Met Leu Arg Ala Phe Leu Cys Glu Val Gln Asp Ile Ile Pro Ile Gln 870 875 880 ctt gta gca ctc act gat ggc gct gta gat gtc ctg gac aat gac tta 2866 Leu Val Ala Leu Thr Asp Gly Ala Val Asp Val Leu Asp Asn Asp Leu 885 890 895 agt agg gaa cag cta act gag ggg gag atg gct caa gaa att gac 2914 Ser Arg Glu Gln Leu Thr Glu Gly Glu Glu Ile Ala Gln Glu Ile Asp 900 905 910 gga agg ttc aca agc atc ccc tgt agc caa ccc cag cat aaa ctt gag 2962 Gly Arg Phe Thr Ser Ile Pro Cys Ser Gln Pro Gln His Lys Leu Glu 915 920 925 930 930 atc ttt cac cca ttt ttt aaa gat gtg gtg gaa aaa aag aac ata atc 3010 Ile Phe His Pro Phe Phe Lys Asp Val Val Glu Lys Lys Asn Ile Ile 935 940 945 gag gct act cat atg tac gat aat gct gcc gag gcc tgt agc acc acc 3058 Glu Ala Thr His Met Tyr Asp Asn Ala Ala Glu Ala Cys Ser Thr Thr 950 955 960 gaa gag gtg ttt aac tcc ccc cgg gca gga tca ccg ctc tgc a ac tca 3106 Glu Glu Val Phe Asn Ser Pro Arg Ala Gly Ser Pro Leu Cys Asn Ser 965 970 975 aac ctg cag gat tca gaa gaa gat atc gag cca tct tac agc ctg ttt 3154 Asn Leu Gln Asp Ser Glu Glu Asp Ile Glu Pro Ser Tyr Ser Leu Phe 980 985 990 cga gaa gac aca tca ctg cct tct ctg tcc aaa gac cat tct aag ctc 3202 Arg Glu Asp Thr Ser Leu Pro Ser Leu Ser Lys Asp His Ser Lys Leu 995 1000 1005 1010 tct atg gaa ctg gag gga aat gat ggg ctg tct ttc att atg agc aat 3250 Ser Met Glu Leu Glu Gly Asn Asp Gly Leu Ser Phe Ile Met Ser Asn 1015 1020 1025 ttt gag agt aaa ctg aac aac aaa gta cct ccg cca gtc aaa cca aag aag Ser Lys Leu Asn Asn Lys Val Pro Pro Pro Val Lys Pro Lys 1030 1035 1040 cct cct gtc cat ttt gaa att aca aag ggg gat cta tct tat tta gac 3346 Pro Pro Val His Phe Glu Ile Thr Lys Gly Asp Leu Ser Tyr Leu Asp 1045 1050 1055 caa ggc cat agg gat gga cag agg aag tct gtg tct tct agc ccc tgg 3394 Gln Gly His Arg Asp Gly Gln Arg Lys Ser Val Ser Ser Ser Pro Trp 1060 1065 1070 ctg cct cag gat ggg tt t gat cct tct gac tat gct gaa ccc atg gat 3442 Leu Pro Gln Asp Gly Phe Asp Pro Ser Asp Tyr Ala Glu Pro Met Asp 1075 1080 1085 1090 gct gtg gtg aag cca agg aat gaa gaa gaa aac ata tac tcc gtg ccc Val Val Lys Pro Arg Asn Glu Glu Glu Asn Ile Tyr Ser Val Pro 1095 1100 1105 cat gac agc acc caa ggc aaa atc atc acc att cgg aat atc aac aaa 3538 His Asp Ser Thr Gln Gly Lys Ile Ile Thr Ile Arg Asn Ile Asn Lys 1110 1115 1120 gcc cag tcc aac ggc agc ggg aat ggt tct gac agt gaa atg gac acc 3586 Ala Gln Ser Asn Gly Ser Gly Asn Gly Ser Asp Ser Glu Met Asp Thr 1125 1130 1135 agc tct cta gag cga ggg tgcc aag gtt atc gtg agc aag cca gtg 3634 Ser Ser Leu Glu Arg Gly Arg Lys Val Ser Ile Val Ser Lys Pro Val 1140 1145 1150 ctg tac agg acg aga tgc acc cgg ctg ggg cgg ttt gct agt tac cgg 3682 Leu Tyr Arg Thr Arg Cys Thr Arg Leu Gly Arg Phe Ala Ser Tyr Arg 1155 1160 1165 1170 acc agc ttc agc gtg ggg agt gat gat gag ctg ggg ccc atc cgg aag 3730 Thr Ser Phe Ser Val Gly Ser Asp Asp Glu Leu Gly Pro Ile Arg Lys 1175 1180 1185 aaa gag gag gat cag gca tcc cag ggt tat aaa ggg gac aat gct gtc 3778 Lys Glu Glu Asp Gln Ala Ser Gln Gly Tyr Lys Gly Asp Asn Ala Val 1190 1195 1200 att cca tac gaa aca gac gac gac gac cgg agg agg aat att ctt cgc 3826 Ile Pro Tyr Glu Thr Asp Glu Asp Pro Arg Arg Arg Asn Ile Leu Arg 1205 1210 1215 agc cta agg agg aac act aag aaa cca aag ccc aaa ccc cgg cca tcc 3874 Ser Leu Arg Arg Asn Thr Lys Lys Pro Lys Pro Lys Pro Arg Pro Ser 1220 1225 1230 atc aca aag gca acc tgg gag agt aac tat ttt ggg gtg ccc tta aca 3922 Ile Thr Lys Ala Thr Trp Glu Ser Asn Tyr Phe Gly Val Pro Leu Thr 1235 1240 1245 1250 act gtc gtg act cca gag aag ccg atc ccc att ttt att gaa aga tgt 3970 Thr Val Val Thr Pro Glu Lys Pro Ile Pro Ile Phe Ile Glu Arg Cys 1255 1260 1265 att gag tac att gaa gcc aca gga ctg agc acg gaagg tac cgg 4018 Ile Glu Tyr Ile Glu Ala Thr Gly Leu Ser Thr Glu Gly Ile Tyr Arg 1270 1275 1280 gtc agc ggg aac aag tct gag atg gag agt ctg cag aga cag ttt gat 4066 Val Ser Gly As n Lys Ser Glu Met Glu Ser Leu Gln Arg Gln Phe Asp 1285 1290 1295 caa gac cac aac ctg gac ctg gca gag aaa gac ttt acg gtg aat acc 4114 Gln Asp His Asn Leu Asp Leu Ala Glu Lys Asp Phe Thr Val Asn Thr 1300 1305 1310 gtg gct ggt gcc atg aag agc ttt ttc tca gaa ctg cct gac ccc ctg 4162 Val Ala Gly Ala Met Lys Ser Phe Phe Ser Glu Leu Pro Asp Pro Leu 1315 1320 1325 1330 gtc ccg tat aac atg cag atg gac gac gca cac aaa atc aac 4210 Val Pro Tyr Asn Met Gln Ile Asp Leu Val Glu Ala His Lys Ile Asn 1335 1340 1345 gac cgg gag cag aag ttg cat gcc ctt aag gag gta tta aag aaa ttt 4258 Asp Arg Glu Gln Lys Leu His Ala Leu Lys Glu Val Leu Lys Lys Phe 1350 1355 1360 cca aag gaa aac cac gaa gtc ttc aag tat gtc atc tct cac cta aac 4306 Pro Lys Glu Asn His Glu Val Phe Lys Tyr Val Ile Ser His Leu Asn 1365 1370 1375 aag gtc cac aac aac aag gtg aat ctc atg acc agc gag aac ctc 4354 Lys Val Ser His Asn Asn Lys Val Asn Leu Met Thr Ser Glu Asn Leu 1380 1385 1390 tcc atc tgc ttc tgg ccc acc ttg atg aga c ct gat ttc agc act atg 4402 Ser Ile Cys Phe Trp Pro Thr Leu Met Arg Pro Asp Phe Ser Thr Met 1395 1400 1405 1410 gac gcc ctc aca gcc acg cgc acc tac cag aca atc att gaa ctc ttt 4450 Asp Ala Leu Thr Ala Thr Arg Thr Tyr Gln Thr Ile Ile Glu Leu Phe 1415 1420 1425 atc cag cag tgc ccc ttc ttc ttc tac aat cgg ccc atc acc gag ccc 4498 Ile Gln Gln Cys Pro Phe Phe Phe Tyr Asn Arg Pro Ile Thr Glu Pro 1430 1435 1440 ccc ggc gcc agg ccc agc tcc ccc tct gcc gtg gct tcc acc gtc ccc 4546 Pro Gly Ala Arg Pro Ser Ser Pro Ser Ala Val Ala Ser Thr Val Pro 1445 1450 1455 ttc ctc act tcc acg cct gtc aca agt cag ccg tcg ccc cca cag tcg 4594 Phe Leu Thr Ser Thr Pro Val Thr Ser Gln Pro Ser Pro Pro Gln Ser 1460 1465 1470 cct cca ccc acc ccc cag tcc cca atg cag cca ctg ctt ccc tcc cag 4642 Pro Pro Pro Thr Pro Gln Ser Pro Met Gln Pro Leu Leu Pro Ser Gln 1475 1480 1485 1490 ctt caa gcc gaa cac acg ctg tgagccacca agacctgggg cgacaggaga 4693 Leu Gln Ala Glu His Thr Leu 1495 accggtcctc tctctgacgg ggtggcattt ggccttgaac aaaaccaagt ccactgggga 4753 cagaggcagg ggcaagtggc tctccccatt accttctcaa gacctcagtg ggagcaccag 4813 ccaatggtac catcggctgg gctgccaggt accctgggcc tggcgctgca gacctgagct 4873 ggcttggacc catttgagga ctgaactagg caggcaatgg ctccagtgcc ctccctctgt 4933 tccctggacc accaccccac gtagctgctc acaccagcct ccgggtgcct ccctctgctt 4993 gtacagagcc catggtcggg acagtgccct ggcctttgcc ggggaggagg atgctctgag 5053 attcagggtg gggctggcaa cccctgaaga gaacacttcc tgttggtctg tctcttccca 5113 ccttccatct gcacacaccc ccaaggtaag ggtacagccc ggctggcggc ctccttggga 5173 acgtgtaggc cacggctctg ccaccactag gtacctgctg agggcgctgg ctctgcagat 5233 cagaacaacg gaggatagct ttgtgcctgg acccagagag tgtgggactc cccgcttcat 5293 ccccaccgtc ccactccaca gccttcccga aacattccct ggcaaacaaa ggaacactag 5353 gagaaaaaat ggaaaaaccc ttccagtaat taaaaaggaa gaaaccacag aaagaaaact 5413 acagacctca agattccact ctgtgcccgc ctctgccggg agggagggag gcacacaggt 5473 ggagctgacc ctcgtctttg tggcagcaaa accaggatgc ctggagctgt ggcctgaggg 5533 cctgctgggg tcccactcac ccacttaggt ctagtcgcta gatcc cccgt tttcccaaga 5593 agagggttcg agcccttggt ggggacagct ggggagatgg cagtgcaggc tggaacctgg 5653 gctgccccag aacacagtcc attacgatag aaacactagg caccccccag gcgagagcta 5713 gtggggtgca gagggcccca tgccagacag cccttggggc tcgttgcact ttaagaaata 5773 ggatctgtgg tgtattccag ggggcctgat ggacaccttt cccgggcgtc tgcagctgcc 5833 ctgcccgtgc ccgcctgcag tggttggaga cgggagtggc ccttcggctc ccgagctccc 5893 tctggggacg gctggctcac tgtctccagt tctcaatggc caacgaaggt gcttggaaac 5953 acctaacctt gcaagtttta ccgccttttg aggaacacaa atcggagaac aaacccaggg 6013 ttcaggcgtg ttttctgtga atgttggatg atgaattttt gtctcttctg gtggagctgt 6073 gcctggccct gtaggcccag ggttggctgg aaggtgacat ctgtgtttcg ttttagctga 6133 ggttggcaga aacgttccca aactccccca gccctggacc ccagcagatg aggaaacggc 6193 cccatttact gaccccgccc ccttttcgag gttatgctca cctggtcagc tcctcacgta 6253 attgggggtg gagggaaagc atggtggtgc cctgggccgt ccctgtgtga acgcaggcaa 6313 aagcagccca gtccccctca ctgcttgagc taacactgcc acctcttttg tgtgagcaca 6373 aaagccacgt cccaagccac ctggcccgat tccacagatg tatgtgcggc cagtgacttc 6433 cccaggagtg tggagggggt ggtgaggagg agcacctggg ctctctaccc ctctcctcac 6493 agaagtacct gaaactaggt ctggggcact cccaatgcag cgccttgtca gccaaggtgg 6553 gcaggcaggg actgtggcag cttatgtcca aagggagccc ccatgcacag gaagccacag 6613 ggttcctctt gtttcccccg ctaacttcag cctctcatct gctgctccgg gctgagggac 6673 tagaggacat ctcggtcgtt tgaggggcat ggccagtcgt ggcaggccgg ccttcagcgt 6733 ccggtcaggg aagcgtgcag cccaaatggg cacttgcatg ggagccacag aggagcgtcc 6793 ctggggattg ttgggaccat gctgccccca ctcccgcttt tgttggggct ctaagttctg 6853 gaaggtgtgt gcacagaggg tgctcatggg actcgcatgc agctctcagc actgggtggg 6913 agggcgttgg cttgtccaga atggggacgt ggggcagcca cccctgccca gcgagagcgc 6973 agacaccgtg tgaggggaca gcagcccttg gtgcaaagcc agagactgat cctggctctg 7033 acggctgaag agggaagacc caaggctggg tggcgtggct cgtgaatcca cttagaattc 7093 ttggcttgtg tcgcatactg ggtgtcacgg cacacattta ctctgcattg tccccgtctt 7153 tcccatcgcc tagcgtttgg ggaggaacag ggagagagct tcggggcgtc tgtctccgtg 7213 ctctcctgcc tccaccgcct tggttttgct tcctgctgga ggcagggcac ctgct gcgac 7273 ccagattctt ctgcaggatg tgtctgtctt tgtcacggtg gacagagggt gacatcatag 7333 gagcagctcg ctggccagaa ggggatgggg gcatccctgt gcctcactca gctcctgctg 7393 ctcttaggga aaggaggcct gggtcaagcc agcatcccct tggtaaagac ccccgcaggc 7453 caccaggcat tctggacaca cacacacaca cacacacaca cacacacaaa acttcacagc 7513 aggccagctg cagtgacttg tcatcaagag tcacctcagc tgcgcccccc tcccatcctt 7573 tcctatgaga agccactgct ttgggggcgc cggctagaaa aagtagggtg cggtggccag 7633 gagggcccct gccgcgcggg gggctgggtc tggttgagtc gctgctttcc cgagggcagc 7693 gcagggatcc ggggaagctg cggcagggag cgggcgccgg cttcgtggct ctgaggtgta 7753 acgggggtgg gctccctccc tcggaggaca tcgtctgtgt ccaggtcaga aagtggcccc 7813 ggaaggggg agtttctgtc gcgggcggggcggcgg <210> 199 <211> 7190 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1599) .. (3926) <400> 199 gagagcgaga gtgagtgagt gtgagtgcgg ggtggggtgg tggccgttac gttcggggca 60 acggctacgg cagtggagaa gtaagaagag aaacaacgtc cggcgcttcc gccttcgctt 120 aggaggagga agagctggta gggaaaggaa agtgcttcgc cctgggcctg gactggaccg 180 agtcgggttg gtgggggtct gggctatgag cttttgaggg tcgcctggga cgcggagcga 240 gacacgagag ccaggagcta tgtctcagcc gccgccgccg ccgcctccgt tgccgccgcc 300 acctcctccc cctgaggctc cacagactcc gtcgtccttg gcgtcggcgg ctgcttcggg 360 ggggcttttg aagcggagag accggagaat cctttccggg agctgcccgg atccgaagtg 420 tcaggcgcgt ctatttttcc cggcctccgg ttctgtcagc atcgagtgta ccgagtgcgg 480 ccagcggcac gagcagcaac agctgctggg ggttgaggag gtgaccgacc cggacgtagt 540 gctacacaac ctgctgcgga acgcgctgct cggggttacg ggggcaccca agaagaacac 600 ggaactggta aaggtgatgg gcctttccaa ctatcactgc aaattgttgt cgcccatatt 660 agctcgctat ggaatggaca aacagacagg ccgggccaag cttctccggg acatgaacca 720 gggcgaactg ttcgattgcg ccttactggg tgaccgcgcc ttcctcatag aaccagagca 780 tgttaacact gtgggctatg gcaaggaccg ctccggaagc ctcctgtatt tgcatgacac 840 tctggaggac attaagcggg ccaataaaag ccaggaatgt ctcattccag tgcatgtgga 900 cggggatgga cactgcttgg tgcatgctgt gtctcgggct ctagtaggcc gagagctctt 960 ctggcatgcc ttaagagaga atcttaaaca gcactttcag cagcacctgg cccgatatca 1020 agctctgttc catgacttca ttgatgctgc tgagtgggag gacattatca atgagtgtga 1080 ccctctgttt gtaccacctg agggtgttcc cttgggcctg aggaatatcc acatatttgg 1140 tcttgccaat gtgctacatc gtcctattat tctgttagat tccctcagtg gcatgagaag 1200 ctctggtgat tattcagcca cctttctacc tgggctcatc cctgcagaga agtgcactgg 1260 gaaagatggt catttgaaca aaccaatctg tattgcatgg agcagctccg gtagaaacca 1320 ttatatcccc ttggtaggca taaaaggggc tgctttgccc aaactgccta tgaatttgct 1380 tcctaaagca tggggtgtgc ctcaggacct tattaaaaag tacataaaac ttgaagagga 1440 tggtggttgt gttattggag gtgacagaag tttgcaagat aaatacttac ttaggcttgt 1500 tgctgctatg gaagaagtct ttatggacaa acatggtatc catcctagtt tggttgctga 1560 tgtccatcag tatttctaca gaaggactgg agtgatag gag ttc agc ctg agg aag 1616 Glu Phe Ser Leu Arg Lys 1 5 tca cag cag ctg cta aaa aaa gca gta atg gat aat cgc ctt cac aaa 1664 Ser Gln Gln Leu Leu Lys Lys Ala Val Met Asp Asn Arg Leu His Lys 10 15 20 tgt ttg ctc tgt ggt gcc ctt tct gaa ctt cat gtt cct cca gag tgg 1712 Cys Leu Leu Cys Gly Ala Leu Ser Glu Leu His Val Pro Pro Glu Trp 25 30 35 ttg gct cct gga ggg aaa ttg tat aac ctg gca aaa agt act cat gga 1760 Leu Ala Pro Gly Gly Lys Leu Tyr Asn Leu Ala Lys Ser Thr His Gly 40 45 50 cag ctg agg act gac aaa aat tac agc ttt ccc ttg aac aat ttg gtt 1808 Gln Leu Arg Thr Asp Lys Asn Tyr Ser Phe Pro Leu Asn Asn Leu Val 55 60 65 70 tgc tca tat gat tca gtg aaa gat gtt ctg gta cca gac tat gga atg 1856 Cys Ser Tyr Asp Ser Val Lys Asp Val Leu Val Pro Asp Tyr Gly Met 75 80 85 agt aac cta aca gct tgt aat tgg tgc cat ggc aca tct gtg cga aag 1904 Ser Asn Leu Thr Ala Cys Asn Trp Cys His Gly Thr Ser Val Arg Lys 90 95 100 gtc aga gga gat ggg tct att gtg tat ttg gat gga gac aga act aat 1952 Val Arg Gly Asp Gly Ser Ile Val Tyr Leu Asp Gly Asp Arg Thr Asn 105 110 115 tct agg tcc act ggt ggc aaa tgt ggt tgt gga ttc aaa cac ttt tgg 2000 Ser Arg Ser Thr Gly Gly Lys Cys Gly Cys Gly Phe Lys His Phe Trp 120 125 130 gat ggt aag gag tat gac aat cta cca gaa gct ttc cct att act tta 2048 Asp Gly Lys Glu Tyr Asp Asn Leu Pro Glu Ala Phe Pro Ile Thr Leu 135 140 145 150 gaa tgg ggt gga aga gtg gtc aga gaa aca gta tat tgg ttc cag tat 2096 Glu Trp Gly Gly Arg Val Val Arg Glu Thr Val Tyr Trp Phe Gln Tyr 155 160 165 gaa agt gat tca tct ttg aat agt aat gtt tac gat gtt gca atg aaa 2144 Glu Ser Asp Ser Ser Leu Asn Ser Asn Val Tyr Asp Val Ala Met Lys 170 175 180 ctt gtt acc aag cac ttt cca ggt gaa ttt ggg agt gaa atc cta gtt 2192 Leu Val Thr Lys His Phe Pro Gly Glu Phe Gly Ser Glu Ile Leu Val 185 190 195 cag aaa gtt gtc cac act ata ttg cat cag act gcc aaa aag aat ccc 2240 Gln Lys Val Val His Thr Ile Leu His Gln Thr Ala Lys Lys Asn Pro 200 205 210 gat gat tat act cct gta aat ata gat ggt gct cat gcc caa aga gtt 2288 Asp Asp Tyr Thr Pro Val Asn Ile Asp Gly Ala His Ala Gln Arg Val 215 220 225 230 gga gat gtt caa gga caa gaa tca gag tct cag ctc cca act aaa att 2336 Gly Asp Val Gln Gly Gln Glu Ser Glu Ser Gln Leu Pro Thr Lys Ile 235 240 245 att ctt act gga cag aaa aca aaa act ttg cac aag gag gag tta aac 2384 Ile Leu Thr Gly Gln Lys Thr Lys Thr Leu His Lys Glu Glu Leu Asn 250 255 260 atg agt aaa act gaa aga act att caa cag aat att acg gaa cag gct 2432 Met Ser Lys Thr Glu Arg Thr Ile Gln Gln Asn Ile Thr Glu Gln Ala 265 270 275 275 tct gta atg cag aaa cgg aaa aca gag aag tta aaa caa gaa caa aaa 2480 Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys Gln Glu Gln Lys 280 285 290 ggg caa ccc agg act gtt tct ccc agt acc att cgt gat ggt cca tcc 2528 Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg Asp Gly Pro Ser 295 300 305 310 tct gca cct gct aca cct acc aag gct ccc tat tca ccg aca act tct 2576 Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser Pro Thr Thr Ser 315 320 325 aag gag aag aag atc cga atc aca act aat gat gga cga cag tcc atg 2624 Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly Arg Gln Ser Met 330 335 340 gtt acc ctt aag t ct tca aca acc ttt ttt gaa ctt cag gaa agt ata 2672 Val Thr Leu Lys Ser Ser Thr Thr Phe Phe Glu Leu Gln Glu Ser Ile 345 350 355 gcc aga gaa ttc aac att cct cca tat tta cag tgt att cga tac ggg 2720 Ala Arg Glu Phe Asn Ile Pro Pro Tyr Leu Gln Cys Ile Arg Tyr Gly 360 365 370 ttt cct cct aaa gag tta atg cca cca cag gca gga atg gaa aag gaa 2768 Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly Met Glu Lys Glu 375 380 385 390 cca gtt cct tta cag cat ggc gac aga att aca ata gaa att cta aaa 2816 Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile Glu Ile Leu Lys 395 400 405 agt aaa gct gaa ggt ggt cag tct gct gca gca cac tca gcc cac act 2864 Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His Ser Ala His Thr 410 415 420 gtg aaa caa gaa gat att gct gtt act ggt aaa ctg tca tct aag gaa 2912 Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu Ser Ser Lys Glu 425 430 435 ctt cag gag caa gct gaa aaa gaa atg tac tcc ttg tgt ctt tta gca 2960 Leu Gln Glu Gln Ala Glu Lys Glu Met Tyr Ser Leu Cys Leu Leu Ala 440 445 4 50 aca tta atg gga gaa gat gta tgg tct tat gca aag gga ctt cct cac 3008 Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys Gly Leu Pro His 455 460 465 465 470 atg ttt cag cag ggt ggt gta ttc tac agt att atg aag aaa acc atg 3056 Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met Lys Lys Thr Met 475 480 485 ggt atg gct gat ggc aag cat tgt act ttt cca cat ctg cct ggc aaa 3104 Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His Leu Pro Gly Lys 490 495 500 acc ttt gtc tat aat gct tct gaa gat aga ctg gaa ttg tgt gtg gat 3152 Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg Leu Glu Leu Cys Val Asp 505 510 515 gct gca gga cat ttc ccc att ggt cct gat gtt gaa gat tta gtt aaa 3200 Ala Ala Gly His Phe Pro Ile Gly Pro Asp Val Glu Asp Leu Val Lys 520 525 530 gag gct gta agt cag gtt cga gca gag gct act aca aga agt agg gaa 3248 Glu Ala Val Ser Gln Val Arg Ala Glu Ala Thr Thr Arg Ser Arg Glu 535 540 545 550 tca agt ccc tca cat ggg cta tta aaa cta ggt agt ggt gga gta gtg 3296 Ser Ser Pro Ser His Gly Leu Leu Lys Leu Gly Ser Gl y Gly Val Val 555 560 565 aaa aag aaa tct gag caa ctt cat aac gta act gcc ttt cag gga aaa 3344 Lys Lys Lys Ser Glu Gln Leu His Asn Val Thr Ala Phe Gln Gly Lys 570 575 580 ggg cat tct tta gga act gca tct ggt aac cca cac ctt gat cca aga 3392 Gly His Ser Leu Gly Thr Ala Ser Gly Asn Pro His Leu Asp Pro Arg 585 590 595 gct agg gaa act tca gtt gta aga aag cat aat aca ggg aca gac ttt 3440 Ala Arg Glu Thr Ser Val Val Arg Lys His Asn Thr Gly Thr Asp Phe 600 605 610 agt aat agt tcc act aaa aca gag cct tct gta ttc aca gct tct tct 3488 Ser Asn Ser Ser Thr Lys Thr Glu Pro Ser Val Phe Thr Ala Ser Ser 615 620 625 630 agt aat agt gag ctt att cga ata gct cct gga gta gta aca atg aga 3536 Ser Asn Ser Glu Leu Ile Arg Ile Ala Pro Gly Val Val Thr Met Arg 635 640 645 gac ggc agg cag ctt gat cct gat ttg gtt gag gcc cag cga aaa aaa 3584 Asp Gly Arg Gln Leu Asp Pro Asp Leu Val Glu Ala Gln Arg Lys Lys 650 655 660 ttg cag gaa atg gtt tct tct att cag gct tca atg gac agg cac ctt 3632 Leu Gln Glu Met Val Ser Ser Ile Gln Ala Ser Met Asp Arg His Leu 665 670 675 cgg gat caa agt aca gag cag tca cca tct gat ctt cct caa agg aaa 3680 Arg Asp Gln Ser Thr Glu Gln Ser Pro Ser Asp Leu Pro Gln Arg Lys 680 685 690 aca gaa gtt gtg agt tct tct gca aag tct ggg agt ctt cag act ggt 3728 Thr Glu Val Val Ser Ser Ser Ala Lys Ser Gly Ser Leu Gln Thr Gly 695 700 705 710 ttg cct gaa tct ttt cct tta act ggt ggt act gaa aat ttg aat aca 3776 Leu Pro Glu Ser Phe Pro Leu Thr Gly Gly Thr Glu Asn Leu Asn Thr 715 720 725 gaa aca act gat ggc tgt gta gca gat gca ctg gga gca gcc ttt gcc 3824 Glu Thr Thr Asp Gly Cys Val Ala Asp Ala Leu Gly Ala Ala Phe Ala 730 735 740 aca agg tca aaa gca caa agg gga aat tcc gtg gag gag ctt gaa gag 3872 Thr Arg Ser Lys Ala Gln Arg Gly Asn Ser Val Glu Glu Leu Glu Glu 745 750 755 atg gat agt caa gat gct gat atg act aac aca act gag cca atg gat 3920 Met Asp Ser Gln Asp Ala Glu Met Thr Asn Thr Thr Glu Pro Met Asp 760 765 770 cac tct tgatttaatt agaggctaat aaaggcagaa tgtttattgt gaatatgtaa 3976 His Ser 775 tatttgttgg ctgggccacg taacttgatt agtcattaaa aatcttgtac gtatataatt 4036 caaagattat atcttgttat tcagtgcatg atagcaagtg tgtgattggc catagctttt 4096 aatatactgc tgcccaggct ggctctgaat ttctataaat tagctgttag atctgctgag 4156 atgactttct tccatatatg tggttcattg gaagttcttt gtaattttaa ttccatgaaa 4216 gtcttaatgt ttccaacatg aaaattctct tacttaaata cgtttgattt ctgaaaagcc 4276 tacaaatgga ggggaaatga gattgtgcta atgttgatgt catcaaggta accatctcat 4336 atactagtgt caaaaggttt atgtaaactt gaattttatc tgaactaaat tgtatcttaa 4396 aattcataca attatttatt agacagtgga atgcaaatgt ttctatgaac gtaaacacat 4456 tcatagagat ttcttggcga aaatatcttg agaatagaat gtaacgatat aacattttgc 4516 tgatttgtgc aagattgggg aaaaatttct tctagattga tgaggtcaat gtgattcagt 4576 tgtgttgctg tctgagccac agccaattgt gtgtgctcta ttaatatgtt accattattt 4636 ttgattcctg gcttggtcaa gaacaacctg attttttttt ttttaatctt gcagaaaagt 4696 tgattgcaaa gtgtggtaga aaaagaaata atggtagcag tagagaattt ataaataaga 4756 gtttatcttt atgaatgagt taattgttct acaattttga tcagtggtat ttaagcctgt 4816 atatgc taag tgtatttatg cccctttgag ccaaaatttt tttttttttt tcagaatcca 4876 taagagttta tttgttggct tcacttgggt ttagatgcaa attttactgc atcacaccct 4936 gatcagctgg gtatttgctt agtgtattca tcaaatcttc agtgccagtt tccttgagaa 4996 gcagctttca tgcttattcc ttaaaaacaa cagaagagtg tttatcctga gattggtatt 5056 gcactatttt attttattct gcaaatctgt atcctgaagt gtacatttca acccatattc 5116 ttctctgttc actgaaatta agttgaattt gaatggctga aagacaaaat atatgttaat 5176 acaatctctt acctagagca ttcaaagcct ggctgtctct gtttgcacat gtaacagatg 5236 cagaactgtg tttgtaattc taagaaaatg tatgtcagaa agtattttat cagatgttta 5296 aaaatctctg cctgttgatt cataagggat atagacagta ctttaacttg tgtttccaga 5356 taaggcagat tttggtcatc tttctgtgaa agtatctcta actgaatcca cttcttaaac 5416 aaactactct attttaaata aggaaagaat ggagaatcta gacattttac aggtgtatct 5476 gagcaaaata tatatttggg ttagttttta tcacattatc acgtttgtct ttatatttta 5536 tcttcatcct aaattttctc cctatcaaaa cagcaggaaa tttttaaact tttatattgt 5596 acactatttt tgcataaaat aagagctgta gctaccaaat actatttact acttagtaaa 5656 ggtggcttct gtgtattaaa ctacgaatta caaatatcac ttcactaacc actataatta 5716 tttttggctt tttcagccac tggaactttt tttgggggga tttaaataca ggaaaactgt 5776 ttaagcaaaa aatgcactgc tttcatgtaa aatgatataa tcttctttaa caaatatttt 5836 cttcattgat aactgacaga tatctcatag cattaacata aaataccaga aacaaacttt 5896 atctccctat tcttacattt agtgcaaatt ggaatgcgta tgtgaatgtt agaagatgga 5956 cttaatctct gacaacttta ttaatttctc tagctacagc aatgctattt aaaagccagt 6016 taggtatgaa tagtacagta atagtttggg ttctcccttg ataaatgaat aaaaggctca 6076 attctgataa gtgatcaaat ttcttgaaat tctttcaaat cagctgaaaa tttggttggg 6136 gtgaattgat ggtttttgag aagtaggcca ggtatcctca caaagaagtt ttagaatagg 6196 gtttctttta agtttttaaa tatcatcctt tgtctttcca tatggttttc ataaccaaat 6256 acatgactat agcatggtta tttttctagt actgccattt gtgatatagc cacatcttgg 6316 cgtgcaagct agacatctca ggtaaatttg tttttttttt tttttttagc cctagaggta 6376 acattataac taaaatgcat tcctgcaatt ctgtttgcag tgcttcacta aacattgaaa 6436 taaagttgta aattttttct tcagtaatcc attttatagt taatcatacc aaatttaagt 6496 tgatgaccta aagtcc aggt agtgttgaag atagtatgta tctagaatac tggtaatgag 6556 aaattgttgt aaattgaaga aaacaagatg ctgccatata ttaagataga atataattaa 6616 ctccatgaga atggttactc aggaactagt taaagagcaa acccatttct cccgcttcac 6676 tctgtttcag atatttttat tggaaaatgt tagggtagag gcctgagaaa gttagcaaat 6736 gctattgact gatactggct ctgtgtcttc cagtgatttt tagtttggtt tttacagtca 6796 agcctactgc ttgcaattaa gatatcaatc tgaaatgcat ctgtaattcc tggccacagg 6856 tccttattgc cattattttt aagtatcttc attggagatg aacactgact tttgcatatg 6916 gtctcttacc tcagggaaga tcacttgcta gcaactcata ctactaatga caggtttttg 6976 agaattgtac tgacatcaca tgttagctac taaatgcaaa atgtataaaa gtattgtttt 7036 atgtagttac ctaccaatac tatctgctac cat tgaataactc tctagacta tcatatagtagacctcact 7962 <210> 200 <211> 8082 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (68) .. (1267) <400> 200 ctcgggcagc ccagtctttg ccatccttgc ccagccggtg tggtgcttgt gtgtcacagc 60 cttgtag ccg gga gtc gct gcc gag tgg gcg ctc agt ttt cgg gtc gtc 109 Pro Gly Val Ala Val Lag Tac c gtg agc ccg gag cag ctg gct ggc ttt gat 157 Met Ala Gly Tyr Glu Tyr Val Ser Pro Glu Gln Leu Ala Gly Phe Asp 15 20 25 30 aag tac aag tac agt gct gtg gat acc aat cca ctt tct ctg tat gtc 205 Lys Lys Tyr Ser Ala Val Asp Thr Asn Pro Leu Ser Leu Tyr Val 35 40 45 atg cat cca ttc tgg aac act ata gta aag gta ttt cct act tgg ctg 253 Met His Pro Phe Trp Asn Thr Ile Val Lys Val Phe Pro Thr Trp Leu 50 55 60 gcg ccc aat ctg ata act ttt tct ggc ttt ctg ctg gtc gta ttc aat 301 Ala Pro Asn Leu Ile Thr Phe Ser Gly Phe Leu Leu Val Val Phe Asn 65 70 75 ttt ctg cta atg gca tac ttt gat cct gac ttt tat gcc tca gca cca 349 Phe Leu Leu Met Ala Tyr Phe Asp Pro Asp Phe Tyr Ala Ser Ala Pro 80 85 90 ggt cac aag cac gtg cct gac tgg gtt tgg att gta gtg ggc atc ctc 397 Gly His Lys Hi s Val Pro Asp Trp Val Trp Ile Val Val Gly Ile Leu 95 100 105 110 aac ttc gta gcc tac act cta gat ggt gtg gac gga aag caa gct cgc 445 Asn Phe Val Ala Tyr Thr Leu Asp Gly Val Asp Gly Lys Gln Ala Arg 115 120 125 aga acc aat tct agc act ccc tta ggg gag ctt ttt gat cat ggc ctg 493 Arg Thr Asn Ser Ser Thr Pro Leu Gly Glu Leu Phe Asp His Gly Leu 130 135 140 gat agt tgg tca tgt gtt tac ttt gtt gtg act gtt tat tcc atc ttt 541 Asp Ser Trp Ser Cys Val Tyr Phe Val Val Thr Val Tyr Ser Ile Phe 145 150 155 gga aga gga tca act ggt gtc agt gtt ttt gtt ctt tat ctc ctg cta 589 Gly Arg Gly Ser Thr Gly Val Ser Val Phe Val Leu Tyr Leu Leu Leu 160 165 170 tgg gta gtt ttg ttt tct ttc atc ctg tcc cac tgg gaa aag tat aac 637 Trp Val Val Leu Phe Ser Phe Ile Leu Ser His Trp Glu Lys Tyr Asn 175 180 185 190 aca ggg att ctt ttc ctg cca tgg gga tat gac att agc cag gtg act 685 Thr Gly Ile Leu Phe Leu Pro Trp Gly Tyr Asp Ile Ser Gln Val Thr 195 200 205 att tct ttt gtc tac ata gtg act gca gtt gtg gga gtt gag gcc 733 Ile Ser Phe Val Tyr Ile Val Thr Ala Val Val Gly Val Glu Ala Trp 210 215 220 tat gaa cct ttc ctg ttt aat ttc tta tat aga gac cta ttc act gca 781 Tyr Glu Pro Phe Leu Phe Asn Phe Leu Tyr Arg Asp Leu Phe Thr Ala 225 230 235 atg att att ggt tgt gca tta tgt gtg act ctt cca atg agt tta tta 829 Met Ile Ile Gly Cys Ala Leu Cys Val Thr Leu Pro Met Ser Leu Leu 240 245 250 aac ttt ttc aga agc tat aaa aat aac acc ttg aaa ctc aat tca gtc 877 Asn Phe Phe Arg Ser Tyr Lys Asn Asn Thr Leu Lys Leu Asn Ser Val 255 260 265 270 tat gaa gct atg gtt ccc tta ttt tct cca tgc ttg ctg ttc att ttg 925 Tyr Glu Alu Pro Leu Phe Ser Pro Cys Leu Leu Phe Ile Leu 275 280 285 tct aca gcg tgg atc ctt tgg tca cct tca gat att tta gag cta cat 973 Ser Thr Ala Ala Trp Ile Leu Trp Ser Pro Ser Asp Ile Leu Glu Leu His 290 295 300 cct aga gta ttc tac ttt atg gtt gga aca gcc ttt gcc aac agt aca 1021 Pro Arg Val Phe Tyr Phe Met Val Gly Thr Ala Phe Ala Asn Ser Thr 305 310 315 tgt cag ctg att gtt tgc caa atg agt agt acc cgg tgt c ca act ttg 1069 Cys Gln Leu Ile Val Cys Gln Met Ser Ser Thr Arg Cys Pro Thr Leu 320 325 330 aat tgg ttg ctg gtt cct ctc ttc ttg gtt gtc tta gtg gta aac cta 1117 Asn Trp Leu Leu Val Pro Leu Phe Leu Val Val Leu Val Val Asn Leu 335 340 345 350 gga gta gcc tct tac gtt gag agc att ctc ctg tat aca tta aca act 1165 Gly Val Ala Ser Tyr Val Glu Ser Ile Leu Leu Tyr Thr Leu Thr Thr 355 360 365 gct ttt act ctg gcc cac atc cat tat gga gta cga gtg gta aag cag 1213 Ala Phe Thr Leu Ala His Ile His Tyr Gly Val Arg Val Val Lys Gln 370 375 380 ctg agc agc cat ttt cag att tac ccc ttc tca ttg agg aaa cca aac 1261 Le Ser Ser His Phe Gln Ile Tyr Pro Phe Ser Leu Arg Lys Pro Asn 385 390 395 tca gat tgactaggaa tggaagaaaa gaatattggc ctgtaataat ctttctttgg 1317 Ser Asp 400 gcacaaagaa gtactgtaaa taaatgcttg taaatatttc ctccatcacc attgaactag 1377 actgatctgc ttgacagacg tgggatctca gtatggtact tggacagcag gaatgataca 1437 tataatctga acttgggaaa ttttggacct actaactcta agcctatttt attttttata 1497 aaactatgtg acattttggt tgagcaga at gtacgttaga ccagcaaaat gttcctaatg 1557 gttctaactt cgtgagttta caatgttgtg attcatgcag ggttaaagat gctttgtttt 1617 tattttttaa gtaccaaaat tggtttcaga acactgataa cactcagaaa accacagtgt 1677 gttttcatat ttggaacttt gtaatagcgg gagtagcagt agtccaaacc tagtataggg 1737 aaaggataaa aataagtcac cttcaccaag agatgccaat gattaccaaa caacagacag 1797 ttgccaaata ctggtttctc tttcccctga aaatggcttt tgttctcaaa tgataagaga 1857 gctaatacat ttagctaata ttctagctct ctttattatg gaacagatct tgatagatgg 1917 tttaattttc tcctaaagag aaataatcag ttgagaattt gagaatgggt tgtaattatc 1977 gctcacccat tgggatggtt cattgtttaa atatggcatt ttcccccctt cagctgcagg 2037 ttcctgagat ttggtgcctg tgagctctga ttgtaggaat gcatgtgaca gtcccagtcc 2097 tatggtaatg acttaggagg aatgcagata aaagtacctt gtaagataaa tataaattgg 2157 agttaggaat ttcatgaacc tcactatgac caaaattaat tttttgattc agtttgtctg 2217 tctgtctgtc cttcccctct cttctttttt cagggtgagg tgctgtgttt cttatttcat 2277 acgagataaa acagagagaa gttctctctt ctccagcttg tccatttccc cacttgaaga 2337 aaacttttga tatatatgcc ttactgagta ca tgccccct ttaatgttaa tatgacttgg 2397 agtaatttct gaggtttact gacaaacata aaaatccctt taattgtagt gtagttgttc 2457 tataaaccat attttttcat gatgtggata ttttcttcta tttctttgtc ttcatttaat 2517 ttggtggtgg tgaactttac ttgctgattt tcttttattt ttcactgaat gaagtttgtg 2577 cttgaatgaa gagtgtatct taaaccccct ttttttggac aggctgcact tggataaaat 2637 aggcaccact gtgttgatat gtaattaaat tcataactat ttatgaatgt gaccattgtt 2697 aaatttaatt atagtgtatt tctttcttga atttcagtct gctgctttgt aaaaaataac 2757 tgtaattgat atttcatttt taaaatttat aaattccaat cattgtcatt caagttatta 2817 gaaatgagtc acggcactaa ctcatggttc tatactcatt ttaagaaatt gtaaaggttg 2877 aggtgtattt ggtgactttc tctgagacac agatgaacgt tggaaataga tgagaaatgg 2937 atgcagaata atgcagatag tgatcccatg tttgttaatt gccatcatgg aagtcagaga 2997 attaaccaat taagtgacgg taactatttt ttgtatacct tgttctttgt gatctataaa 3057 attaaactgg ataaaatgtt aattgggggt agggaaaaag ctttgtttta agatttctaa 3117 gctaattatt ttaccgtttt gttgaccttg tacacaagaa tgagattaat ctgtattata 3177 taagaaaaga actgataaat atttataaaa tgacaaac tt ggaccacagg ctttcttgac 3237 cttgtacagt atagtaaaaa taccctttac ttctgacatt aaggtcacgt cctatagttt 3297 gggggctctt ttacttcaaa ggtgtgtttc tgccctcttt tggttgtatc aaatttattt 3357 gaaaattgtt ttgtgctgta ctttatgact tgtttcccta tggtggtaaa gaatgatgcc 3417 atagtcagtt ttattgacat tgttagatga aagaaaagta gctgtcaaca aggggaaagt 3477 gaaattgagc aattcactgt ttcaggatac ttgaggatct ttagtgtact gctgactctt 3537 tttcttgttt tgtctgccat tcttgaaagt gcatcttgag agcccccatt tgttgtgtag 3597 agatatagca gctgaagcag gacttcattc cagatagctg tgtgcattta tgtcatgcca 3657 attactataa catttccaaa gtatgaaagg tctttcaggc ttatgcatga tattgtgggt 3717 gacttcatgc cccagccttt ctccccagca tacagtgagc tgccttttgg ggagcaatgc 3777 catgataagg agcatacgtg catgttttcc gtactttcag aatagagtgc cttagctagg 3837 ccagaggctc gtattgtgtt tctgctgacc aaagttgcat acacctgtaa gaagtgtctt 3897 tttaggttat ggtattaaaa aaagtcgttt caggcttatc agataataat tctcctatat 3957 ttgagggggg catgggataa aaagatttaa taatacctgg atagagaatg ctaatgctgc 4017 cttttgtgat cctttaatat tatccatgct tttataaagt gc agtacaca ttttgacatt 4077 gccacagttt acagtgtcat tcttccacga ataggtaatt gatagagttt atgggtctta 4137 gtcttaaggg taacagagtg aataccttcc aaataaaaag ctaaatattc ctccttgtca 4197 ttttaatgtc attattgaaa tacttttaat tctaattttc aaaagaaagc taaatgctga 4257 ttgtggttta ggatgttaca gtactaatac catcatgtta tttattctaa tatagaggca 4317 ttgagaggag gggagtgtat gtctagagtt accccaattc taaataggta ccaaaagagt 4377 attgattatg acctggagcc tgagctttgg gagaatatac aaaggaaaaa gcaggcatag 4437 tttccacttt aaagggaaga agggacttta acatcctatg aatttgaaac atcctatgaa 4497 tttgaaagtt tcctaagtgt tgttttcaaa gaactggttt attttatagt cagtcaaaat 4557 gcatttggaa tgtaccttgc ttccataaca gactttgact ctatgaccta tgaagaataa 4617 aaagataatc tgaaggtgtt tgagtcagag gctacttttc ccctttatat tttatataga 4677 agcctatttg taattcttcc tcttcgttct tcacctgggt ttcctcttat ctacccacca 4737 cctaggacag aggctgccca ctcaggtctt gccttgttgc ccctagatgt tgccacattc 4797 acatctcctt gatggcctta gatctcttga ctagtcaagg actgggaacg tgccaggggg 4857 aacaaagtaa gcttgatggg ctggaacttt tgactttggg tccccaaa ca gccaaaaaca 4917 gatacagaaa tctttggttg tgtggatgcc tgtgttcaga gtggccttat cttgacctca 4977 gttctggatt taagtactct atagaaaatt tgtgaagtca gaccagaatt ttctttgtcc 5037 catgaggtgt ctttgtaagt cagcatgctc ttgcttgaac accctgtggg tgaataactt 5097 tagtaagtta gctgccagca ttagaacctt ccaggaagaa ttttaactag tatgctacat 5157 ttgaagcact ctgacatgta catttaaagt gacagtttta aaagtaaaat ggtgttaaat 5217 ctctgaaact tgaacgtatg atgctctgga cattttagga agcttaagta aatttctgat 5277 tttcctttat tgattatgta acccacgtga tttgcatatt ttagttttta tgtttgacag 5337 tggtacaaat gactgacatt ggcaggcagt tattgtaggg tatatggtta atcacgattg 5397 tctaactttt ccagagaaag tggtgatatg cttcttcctt gcatggagct gtgggaattg 5457 gatttgttgg ctcttcattt ccagtgtttc tacagtgcag aataaatgta actttttaag 5517 cctgcatgct agtaatatgc tttgctcttt agtaaacaaa tatgcaatag atagtaatct 5577 atctactttt tttaaagcag ggatctgctc cctatctaga cagatctttt aatgcattaa 5637 tatttagagt agcaaaagaa gttttgccat ttgtagctct ctcacaggta gcttaagcga 5697 gggggttgtg ttgcatgtgc ttagaaaggc caggttccca gaattggaag gt gccacata 5757 tacttttaga atattttaac aaaggcttgt ctctaggaaa atccacttgg actgcagcag 5817 gattgttctg gtcttccaca gaccattcac atggtctttc tctccagaga atcattctta 5877 gaaagccagg ctaaatcaga gtagtgctgt ttttaaagca agtatattgg atgatggcta 5937 tagggtacct taatgctctg ttgaaattgg aagcagactg ctcttcagca gcacatatac 5997 tgcaactgaa gttagagaca gtactgaaga cgagggagta gctaaatgct gtggatattt 6057 catgtctgtt tggctaatgt cttctcttga ggagtttcta tgggtagcaa ttaaaattag 6117 aatttatttt aaggttttta ttaaaatata tacaatttgc cataaattct agattctgat 6177 attcttgaca agcacttttt gaatatctca agagtaagtt cttgacctgg aacatatata 6237 gttagtactt gatgtcacta accaagttgt agaaggagcc tgttataatt ctgcaagatc 6297 tgtgaatagc attataaatc tggggcaggt gcctgtaatc ccagcacttt gggaagccaa 6357 ggcaggtgga ttgcttgagc ccaggagttc gacaccaacc tgagcaacat ggcgaaaccc 6417 cgtctgtaat aaaaatacaa aaaaattagc tgggcatggt ggcatgtgcc tgtaatccca 6477 gttactgggg aggctgaggc aggagaatca cttgaacctg ggagatggag attgcagtga 6537 gcagagattg tgccactgca ctccagccag agtgacagag caagactcca tctcaaaa aa 6597 taataataaa aataaacaaa tctgtttaaa ttactgttgc ctttcagcat tagactttga 6657 gtttaataac tacaaattga gactgctcac aatattaact ttttttgtag gttattttgt 6717 tgtttagata acttgcctcc ctagaggagc attcaggaga taaagaccta gctacatgta 6777 atgatatgat catttcaaaa atgtgccaag aaagcaaaat tcattattga actctaaatt 6837 tctgggtttt ttttttttta aagtagcatt ttctctgggt aaagggaaag gcaatgaatg 6897 attgccaaca tgtaaactcc ctgctgcccg ccttccccca gtcccctcca tctaacataa 6957 tacagtaaat ttgtagccag ttgtagaaaa agaaattgat atctttctga gtaaggtttc 7017 atgccctgtg actaagaata ggtggaggaa tcatggccaa atcaaatatg aattgtttag 7077 cttggtcctg ttgcagttgg ctttctgtag tgttctgaaa caagaggacg attccattcc 7137 ttctcaggaa cctagaaaca acaccgcttg agcaactgga atatgtttgc tgcaagcaga 7197 atattttggg gagaggaaga gtagtttaat tcaagtagtt taattgaaca tattagtcat 7257 tggtctgtct gggacgtgca gtgttcatag tagcaatgta tgtaccattt attttatctg 7317 gttgtgtgtg atgtgtgtgt atgcctattt aatatgtaca catatattca ctacatatgt 7377 atgtatgata tattcatata tacatgcagt ctgcttgatt atcagcaaaa tggtcagcct 74 37 ttatcagata gtttcttcat gtggagttca tctgcatgtg gcccttactc tgaagcctct 7497 tcctgatctg gagccacagt ctgtctgtct tccagttcat ctcagtcctc gagaaaggcc 7557 ctttaaatat gtcactttcc cattttcctt taaccatggg ttgtgtgagc cagaaagagc 7617 tttgagaaag atggctgctt ccaccagggt ggaggcttct aggtctgcat gatgatgggg 7677 cccgtttctg gccagagggt ggctctggga gcagttgtgc tgcgggcttg ctgggggaga 7737 actctaactg ttgcagaaac agagcttcat ggcttgctta aattacttag ctggaatatt 7797 ttaaagtgtc agataatgtg atgtacaaag agagtatgcc gatgcatttc attgtttttg 7857 cattatctgt atcagtgttt cccattgcta gcccgaataa tcaagaccag actgtttctt 7917 gtcactggat tctggaagcc ttgccctttc aactggattt atgtttgttt ctgctgctgt 7977 gaaaccccaa agtaatgcatta taggttttatatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagatta ttagattaga <210> 201 <211> 8024 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3127) <400> 201 a aag aaa cat gga tct aaa tgc ctt gtg cac tgc aaa atg ggg gtg agt 49 Lys Lys His Gly Ser Lys Cys Leu Val His Cys Lys Met Gly Val Ser 1 5 10 15 cgc tca gcc tcc acc gtg att gcc tat gca atg aag gaa tat ggc tgg 97 Arg Ser Ala Ser Thr Val Ile Ala Tyr Ala Met Lys Glu Tyr Gly Trp 20 25 30 aat ctg gac cga gcc tat gac tat gtg aaa gaa aga cga acg gta acc 145 Asn Leu Asp Arg Ala Tyr Asp Tyr Val Lys Glu Arg Arg Thr Val Thr 35 40 45 aag ccc aac cca agc ttc atg aga caa ctg gaa gag tat cag ggg atc 193 Lys Pro Asn Pro Ser Phe Met Arg Gln Leu Glu Glu Tyr Gln Gly Ile 50 55 60 ttg ctg gca agc aaa cag cgg cat aac aaa cta tgg aga tct cat tca 241 Leu Leu Ala Ser Lys Gln Arg His Asn Lys Leu Trp Arg Ser His Ser 65 70 75 80 gat agt gac ctc tca gac cac cac gaa ccc atc tgc aaa cct ggg cta 289 Asp Ser Asp Leu Ser Asp His His Glu Pro Ile Cys Lys Pro Gly Leu 85 90 95 gaa ctc aac aag aag gat atc acc acc tca gca gac cag att gct gag 337 Glu Leu Asn Lys Lys Asp Ile Thr Thr Ser Ala Asp Gln Ile Ala Glu 100 105 110 gtg aag acc atg gag agt cac cca ccc ata cct cct gtc ttt gtg gaa 385 Val Lys Thr Met Glu Ser His Pro Pro Ile Pro Pro Val Phe Val Glu 115 120 125 cat atg gtc cca caa gat gca aat cag aaa ggc ctg tgt acc aaa gaa 433 His Met Val Pro Gln Asp Ala Asn Gln Lys Gly Leu Cys Thr Lys Glu 130 135 140 aga atg atc tgc ttg gag ttt act tct agg gaa ttt cat gct gga cag 481 Arg Met Ile Cys Leu Glu Phe Thr Ser Arg Glu Phe His Ala Gly Gln 145 150 155 160 att gag gat gaa tta aac tta aat gac atc aat gga tgc tca tca ggg 529 Ile Glu Asp Glu Leu Asn Leu Asn Asp Ile Asn Gly Cys Ser Ser Gly 165 170 175 tgt tgt ctg aat gaa tca aaa ttt cct ctt gac aat tgc cat gca tcc 577 Cys Cys Leu Asn Glu Ser Lys Phe Pro Leu Asp Asn Cys His Ala Ser 180 185 190 aaa gcc tta att cag cct gga cat gtc cca gaa atg gcc aac aag ttt 625 Lys Ala Leu Ile Gln Pro Gly His Val Pro Glu Met Ala Asn Lys Phe 195 200 205 cca gac tta aca gtg gaa gat ttg gag aca gat gca ctg aaa gca gac 673 Pro Asp Leu Thr Val Glu Asp Leu Glu Thr Asp Ala Leu Lys AlaAsp 210 215 220 atg aat gtc cac cta ctg cct atg gaa gaa ttg aca tct cca ctg aaa 721 Met Asn Val His Leu Leu Pro Met Glu Glu Leu Thr Ser Pro Leu Lys 225 230 235 240 gac ccc ccc atg tcc cct gat cct gag tca cca agc ccc caa ccc agt 769 Asp Pro Pro Met Ser Pro Asp Pro Glu Ser Pro Ser Pro Gln Pro Ser 245 250 255 tgc cag act gaa atc tca gat ttc agt aca gat cgc att gac ttt ttt 817 Cys Gln Thr Glu Ile Ser Asp Phe Ser Thr Asp Arg Ile Asp Phe Phe 260 265 270 agt gcc cta gag aag ttt gtg gag ctc tcc caa gaa acc cgg tca cga 865 Ser Ala Leu Glu Lys Phe Val Glu Leu Ser Gln Glu Thr Arg Ser Arg 275 280 285 tct ttt tcc cat tca agg atg gag gaa ctg ggt gga gga agg aat gag 913 Ser Phe Ser His Ser Arg Met Glu Glu Leu Gly Gly Gly Arg Asn Glu 290 295 300 agc tgt cga ctg tca gtg gta gaa gta gcc cct tccca gt gct 961 Ser Cys Arg Leu Ser Val Val Glu Val Ala Pro Ser Lys Val Thr Ala 305 310 315 320 gat gac cag aga agc agc tct ttg agt aat act ccc cat gca tca gaa 1009 Asp Asp Gln Arg Ser Ser Ser Leu Ser Asn Thr Pro His Ala Ser Glu 325 330 335 gaa tct tca atg gat gag gaa cag tca aag gca att tca gaa ctg gtc 1057 Glu Ser Ser Met Asp Glu Glu Gln Ser Lys Ala Ile Ser Glu Leu Val 340 345 350 agc cca gac atc ttc atg cag tct cac tcg gaa aat gca att tca gtc 1105 Ser Pro Asp Ile Phe Met Gln Ser His Ser Glu Asn Ala Ile Ser Val 355 360 365 aaa gaa att gtc act gaa att gag tcc atc agt caa gga gtt ggg cag 1153 Lys Glu Ile Val Thr Glu Ile Glu Ser Ile Ser Gln Gly Val Gly Gln 370 375 380 att caa ctg aaa gga gac atc tta ccc aac cca tgc cat aca cca aag 1201 Ile Gln Leu Lys Gly Asp Ile Leu Pro Asn Pro Cys His Thr Pro Lys 385 390 395 400 aag aac agc atc cat gag ctg ctc ctt gag agg gcc cag act cca gag 1249 Lys Asn Ser Ile His Glu Leu Leu Leu Glu Arg Ala Gln Thr Pro Glu 405 410 415 aac aaa cct gga cat atg gag caa gat gag gac tcc tgc aca gcc cag 1297 Asn Lys Pro Gly His Met Glu Gln Asp Glu Asp Ser Cys Thr Ala Gln 420 425 430 cct gaa cta gcc aaa gac tca ggg atg tgc aac cca gaa ggc tgc cta 1345 Pro Glu Leu Ala Lys Asp Ser Gly Met Cys Asn Pro Glu Gly Cys Leu 435 440 445 acc aca cac tca tct ata gca gac ttg gaa gaa ggg gaa cca gct gag 1393 Thr Thr His Ser Ser Ile Ala Asp Leu Glu Glu Gly Glu Pro Ala Glu 450 455 460 ggg gaa caa gag ctc cag ggc tca ggg atg cac cca ggt gcc aag tgg 1441 Gly Glu Gln Glu Leu Gln Gly Ser Gly Met His Pro Gly Ala Lys Trp 465 470 470 475 480 tac cct ggg tct gtg agg cga gcc acc ttg gag tt cgc tta 1489 Tyr Pro Gly Ser Val Arg Arg Ala Thr Leu Glu Phe Glu Glu Arg Leu 485 490 495 cgg cag gag caa gag cat cat ggt gct gcc cca aca tgt acc tca ttg 1537 Arg Gln Glu Gln Glu His His Gly Ala Ala Pro Thr Cys Thr Ser Leu 500 505 510 tcc act cgt aag aat tca aag aat gat tct tct gtg gca gac cta gca 1585 Ser Thr Arg Lys Asn Ser Lys Asn Asp Ser Ser Val Ala Asp Leu Ala 515 520 525 cca aaa ggg aaa agt gat gaa gcc ccc cca gaa cat tca ttt gtc ctc 1633 Pro Lys Gly Lys Ser Asp Glu Ala Pro Pro Glu His Ser Phe Val Leu 530 535 540 540 aag gaa cca gaa atg agc aaa ggc aaa ggg aaa tac agt ggg tct gag 1681 Lys Glu Pro Glu Met Ser Lys Gly Lys Gly Lys Tyr Ser Gly Ser Glu 545 550 555 560 gct ggc tca ctg tcc cat tct gag cag aat gcc act gtt cca gct ccc 1729 Ala Gly Ser Leu Ser His Ser Glu Gln Asn Ala Thr Val Pro Ala Pro 565 570 575 agg gtg ctg gag ttt gac cac ttg cca gat cct cag gag ggc cca ggg 1777 Arg Val Leu Glu Phe Asp His Leu Pro Asp Pro Gln Glu Gly Pro Gly 580 585 590 tca gat act gga aca cag cag gaga g gtc ctg aag gat ctg agg act 1825 Ser Asp Thr Gly Thr Gln Gln Glu Gly Val Leu Lys Asp Leu Arg Thr 595 600 605 gtg att cca tac cag gag tct gaa aca caa gca gtc cct ctt ccc ctt 1873 Val Ile Pro Tyr Gln Glu Ser Glu Thr Gln Ala Val Pro Leu Pro Leu 610 615 620 ccc aag agg gta gaa atc att gaa tat acc cac ata gtt aca tca ccc 1921 Pro Lys Arg Val Glu Ile Ile Glu Tyr Thr His Ile Val Thr Ser Pro 625 630 635 640 aat cac act ggg cca ggg agt gaa ata gcc acc agt gag aag agc gga 1969 Asn His Thr Gly Pro Gly Ser Glu Ile Ala Thr Ser Glu Lys Ser Gly 645 650 655 gag caa ggg ctg agg aaa gtg aac atg gaa aaa tct gt c act gtg ctc 2017 Glu Gln Gly Leu Arg Lys Val Asn Met Glu Lys Ser Val Thr Val Leu 660 665 670 tgc aca ctg gat gaa aat cta aac agg act ctg gac ccc aac cag gtt 2065 Cys Thr Leu Asp Glu Asn Leu Asn Arg Thr Leu Asp Pro Asn Gln Val 675 680 685 tct ctg cac ccc caa gtg cta cct ctg cct cat tct tcc tcc cct gag 2113 Ser Leu His Pro Gln Val Leu Pro Leu Pro His Ser Ser Ser Pro Glu 690 695 700 cac aac aga ccc act gac cat cca acc tcc atc ctg agt agc cct gaa 2161 His Asn Arg Pro Thr Asp His Pro Thr Ser Ile Leu Ser Ser Pro Glu 705 710 715 720 gac aga ggc agc agc ctg tcc aca gcc ctg gag aca gca gca cct ttt 2209 Asp Arg Gly Ser Ser Leu Ser Thr Ala Leu Glu Thr Ala Ala Pro Phe 725 730 735 gtc agt cat aca acc cat tta ctg tct gcc agt ttg gat tac ctg cat 2257 Val Ser His Thr Thr His Leu Leu Ser Ala Ser Leu Asp Tyr Leu His 740 745 750 ccc cag act atg gtt cac ctg gag ggc ttc aca gag cag agc agc act 2305 Pro Gln Thr Met Val His Leu Glu Gly Phe Thr Glu Gln Ser Ser Thr 755 760 765 aca gat gag ccc tct gca gaa ca g gtt agc tgg gaa gaa agt cag gag 2353 Thr Asp Glu Pro Ser Ala Glu Gln Val Ser Trp Glu Glu Ser Gln Glu 770 775 780 agc cct ctc tcc agt ggc agt gag gtg cca tat aag gac tcc cag cta 2401 Ser Pro Leu Ser Ser Gly Ser Glu Val Pro Tyr Lys Asp Ser Gln Leu 785 790 795 800 agt agc gca gac cta agt tta att agc aaa ctt ggt gac aac act ggg 2449 Ser Ser Ala Asp Leu Ser Leu Ile Ser Lys Leu Gly Asp Asn Thr Gly 805 810 815 gag tta cag gag aaa atg gac cca ttg cct gta gcc tgt cga ctc cca 2497 Glu Leu Gln Glu Lys Met Asp Pro Leu Pro Val Ala Cys Arg Leu Pro 820 825 830 cat agc tct agt agt gaa ac atc ag agt gtc cac agc ccc ggt 2545 His Ser Ser Ser Ser Glu Asn Ile Lys Ser Leu Ser His Ser Pro Gly 835 840 845 gtg gtg aag gag cgt gct aaa gaa atc gag tct cga gtg gtt ttc cag 2593 Val Val Lys Glu Arg Ala Lys Glu Ile Glu Ser Arg Val Val Phe Gln 850 855 860 gca ggg ctc acc aaa cca tcc caa atg agg cgc tca gct tct ctc gcc 2641 Ala Gly Leu Thr Lys Pro Ser Gln Met Arg Arg Ser Ala Ser Leu Ala 865 870 875 880 880 aaa tta ggt tac ttg gac ctc tgt aaa cac tgc tta cca gag agg gag 2689 Lys Leu Gly Tyr Leu Asp Leu Cys Lys Asp Cys Leu Pro Glu Arg Glu 885 890 895 cct gcc tcc tgt gaa tcc cct cat ctc ctc ctt cat 2737 Pro Ala Ser Cys Glu Ser Pro His Leu Lys Leu Leu Gln Pro Phe Leu 900 905 910 aga aca gac tca ggc atg cac gcg atg gag gac caa gag tcc cta gaa 2785 Arg Thr Asp Ser Gly Met His Ala Met Glu Asp Gln Glu Ser Leu Glu 915 920 925 aac cca ggt gcc ccc cac aac cca gag ccc acc aag tct ttt gta gaa 2833 Asn Pro Gly Ala Pro His Asn Pro Glu Pro Thr Lys Ser Phe Val Glu 930 935 940 caa ctc aca aca aca gag tgt att gtg cag agc aag cca gtg gag agg 2881 Gln Leu Thr Thr Thr Glu Cys Ile Val Gln Ser Lys Pro Val Glu Arg 945 950 955 960 ccc ctt gtg cag tat gcc aaa gaa ttt ggt tct agt cag cag tat ttg 2929 Pro Leu Val Gln Tyr Ala Lys Glu Phe Gly Ser Ser Gln Gln Tyr Leu 965 970 975 ctc ccc agg gca gga ctt gaa ttg act agt tct gaa gga ggc ctt ccc 2977 Leu Pro Arg Ala Gly Leu Glu Leu Thr Ser Ser Glu Gly Gly Leu Pro 980 985 990 gtg cta cag acc cag gga ctg cag tgt gca tgc cca gct cca ggg ctg 3025 Val Leu Gln Thr Gln Gly Leu Gln Cys Ala Cys Pro Ala Pro Gly Leu 995 1000 1005 gcc gtg gca ccc cgt cag caa cac ggc cac ccc ctt agg aga 3073 Ala Val Ala Pro Arg Gln Gln His Gly Arg Thr His Pro Leu Arg Arg 1010 1015 1020 ctg aaa aag gca aat gac aaa aaa cgg aca acc aac ccc ttc tat aat 3121 Leu Lys Lys Ala Asn Asp Lys Lys Arg Thr Thr Asn Pro Phe Tyr Asn 1025 1030 1035 1040 acc atg tgattctgag cctacacatg tgactttcta gaagaaatgt ttgtaaaagg 3177 Thr Met ggcaggtgta atatgtaagg aacatgcact ttattggtta attttataat attttggtca 3237 ttttactgtt tctggtgcat gcagggtttg ggtgtttttc agtgtgtatg tgtgtgtata 3297 tgtaagggga aagagagatt gatctggatg gcaagaccgt ttatcatttt ttatttaaaa 3357 aaatcaaacc tcaaaaaagt cattttcaga gaacaccttt atcaaaggca aattgctgtt 3417 tttcagtcag ctgccacctg cttctcattt tgccctctga gaaaaggcat ggtttcttaa 3477 ttgagggaag gaagcagatt cggaggggtg gagataaagc tggggattgg agatgttccc 3537 ctgcctttgt gatgatggtt tggtttccag acct aggca tcgaatgggc taaaggtcag 3597 ccagaagtca gagggctctc agccttcatc cagccgcagc cctttagagt tcctgaagga 3657 ggcaggttcc gctttgcttt aaaagagggt cttccggtgt tccagagtgt atcgttacag 3717 taagacatga taatggccgg ctctgcaaat ttatcatata gtttttttcc caagaaaatt 3777 atttttgaaa ttaaaacagg accccaaatg aaatccaagt ggtcttctgt agaggaaagc 3837 atgataagag gaggaagaca taaagttggg ggtggagagg ctgctgccca gaaactgctg 3897 ggttggtggg atccacacag atgggcatct tggctctccc tgccagaaaa atgtgctctg 3957 cagtgtcctc ccaactgaaa acaacagtga catgtttgaa aagcagcaat cgaaagtcag 4017 tgtgttcttg taaaatgaat atgtatgtag ggttttaacc cttccattac ttgaataatt 4077 ctttgggcct tctgagttta atggccatat tttcttccag tttattttcc ttccccatgc 4137 tgttgtcccc atgctgccta tttttttaaa tttcatagat tatatttgaa ttgttacata 4197 tgtttaacat ccattgaatg caacgtttta tttttggtat tatcactgtt aacacttttt 4257 tttccttttc ctggaaggtt tgtcatttct ctaaagtttg tacacagtat ttatgtacat 4317 aatattgtca ctgtcttagt gtcttgttca tgttgtaggg taattttgat ttattctttt 4377 taagaaggag tagagttgca actggaaaac acagacacca gaaatgaaag tgttgggtgt 4437 tgataggaat ctgtacaata tgttgatggt ggctgtagtt gtttaaatgg agacttccaa 4497 tcaccagctc ctgccaaatt atgcattagt aactttttcc tcagagacac ccctaaaggc 4557 tcccattagg tcacagcgtg actgaaagct gatttctctg tgagactgaa atcccagaac 4617 attgtttgcc agtatctcaa ccacagccag gaagtatatg tgagttgccc agagtggaag 4677 ctcctagtag aggctgaagg ccacagggga ggcctcagcc aggggcaagt gcccacagtg 4737 actccattta ggatgctgtc gttttgctac tgttgtggag atccttaacg cagcagcgcc 4797 tgtcataaac aagcctcttg tagcttctta cagaaaacag atttagtcta gcatgaaaca 4857 cctctgcatc tcattgaaac tgaagaggct tgcagatttg ctttcgttga tgtccacgtt 4917 actgaggatt gactgagtat agactggaga caggtttttg gcttatcaca gcactgagga 4977 aaatacaaat gcacagactg tcagcatgat gtcagaggcc agagtttggt gggggcagat 5037 ggcagggcga cccaaaagat gcagaaaagg tagactgggg ccactgggtc ttaagaggag 5097 ctgtgaagtt gtgtggaagc caaggctggg tctgacatcc ctgccaggaa gcaggttgga 5157 cagaaaccac ttgctaaaag cgtctctatg gtgcagtgat tatgtgtacc ctgtgctgtt 5217 gctcagtagt ctccttgaat gttcaagtat ctcatccact cagtt ttgtg attcctggat 5277 atttgtgtgt tgtaaagtgt tttgttaggt ggtatgaacc aatgtgagga ggcttgagac 5337 agggttatgg atttccagag ctcttccatg tagaataccc tgccttcttg aagcagttcc 5397 accaccaata tgatggggaa gggcaggaac ttatggcagg gtggggagag ggtttgcctg 5457 gaagttaaga gagtggcatc cacttgtggt aaccccttac gatgatgaca tcccacacac 5517 taagaggtac aagcaggacc aaagttttgg actgttccct cttctcccct ccactgtgtt 5577 taatgttcac tcactgcatt aaataacaac aaagatggga caaaacccac taatactgtg 5637 gggaaaaaaa attttcaaga gcagaggaaa gtctttctgc ctttttataa ttactttttt 5697 tatcatttaa tttacctgcc taaataaaca tcttctacag aatatctgtc attcaaccat 5757 gccaaggagt ttgtgccagc cttttcagac tcccagaatt gggtgttcct gggttattta 5817 catagctgag cagtgtccag gggaggtgcg cagtgaactg tcaaggactt tccagactgt 5877 cttctcttca gacttttata atctccagtg gcatctttcc cttttctttt gttcatgacc 5937 tgacctgaag cagcagattt gatagactgg caaagatgaa taggaaaaac tttgactctt 5997 gcccagtgcc tgcctgcctc tctctctctc ctctctctct ctctcttttt aaaccaccat 6057 agactctcac ttattttgga ggagtgtatg tgcatgtgta cacatatgta catatataaa 6117 aacagttgat gttttggtgt atggggtaaa agccccagga gcatacagaa cttgagctga 6177 acctggtcag tagaaaggga aaccccaacc ctttcttgat ttttggagac acccaggact 6237 aatggatact gtagtagaca tgtagtacta tagtaccgta atattcatct ctcctcattt 6297 tagttgcctt tcagattcta aatgtttggg atcattccta tcatcttagt ctcttcagga 6357 tctttagtat tttcctggtt ctgaggaggc ttgagacagg gttatggatt tccttgttct 6417 gtgtctttat ccctactgat agttcctctt tctcattttg caaactaccc agagctccaa 6477 ggacagcctg aagatctcag tgcctcaggc tctgaggtac tctgctcaca ggccccagac 6537 agatgctgtt gggtaaactc aaagcttcct atgagaagct tctgagatgt agcaggtcac 6597 agaagtgttc acctgtttca tctgaggatt tcagttctga agtgatctag gcatgtttgg 6657 taaaaatgtt tttgtgagag ttcttttttt aagaaagcat tatgcaaaaa gtcactttta 6717 agggcattta aaaattttta agtaaagcca ttctttggct tttttggact atttgtggat 6777 actttgttta cattttgaat attaaaatgt gcatcatctt gtcggccatg cagtcctgca 6837 ggcatcagtg ccctggctgt cctgtgagtc ctcatgcaga gcagggccat catggtcagc 6897 ccttgtgagt aagtgggtat acgctgaagc tgacttccgt ctgtgtcctg ccctc ccatc 6957 cagcactctc tatggaaata gttgtcattt cctcagtgat ggtgtgtctt atagtgatgg 7017 ttgtaatggt gaatggctag tgtcattttg tttaattttg ttttgctttt tgatggtgga 7077 taagatgaaa ttttagctgt ttcagcatca atccaactta aaagcatctt ggactttgtt 7137 ttcccttcca aactaaaaga tcaaggcatg tattagacac aagcatattt gctgcctcaa 7197 ctcctctgac acccatatta ggaaaaggcc tgccaccaaa gcaggaagct gcacactcct 7257 aacccttctc ccagggtgtg gggtcccttg acgtcatgaa gagctattgc aaggtgcttc 7317 tgtacttttc cagcctggaa atggagggtg actggccctg gctcctgcta tgagaagata 7377 accagcctca ttttctcagt gccccagagg tctaggatag gatttctaaa ctggaatcat 7437 ccttaatcac cttgaagatc ccttaagagg catttgactg gtgctgccgt ctgtgtcctc 7497 aaagcaatgc tggtggcagc gtcctgtgta cacatgcaga gctaataccc aaactaaaaa 7557 ctgggtaact ggccctgaag tgcttcccaa tcagtaagcc cacagggaaa tgtttgattt 7617 ttatgttctg ttggattttg gtttgcttgg catatctaaa ggtgccttta cttttctttt 7677 tttttttttt tctttctgct ttgttttgta ggacttgttc taacatggaa aacaagtcca 7737 gaagactctc ctctgactgt tacctttgcc ccaagccacc ccaaactttt atgctcatgt 7797 tttattaaag caggtgctcc ctggaatctc tgggacattt ttgaggcatt tgaagcagaa 7857 tatagagtgg tctcatctcc ttccttaatc ttcctggtgg ttgggatgtt ccacttttat 7917 catagatttt tttattacag atatggat gtgattgat ttgatt gattgatt gattgatt gattgatt gattgatt gattgatt gatta gtta <210> 202 <211> 7981 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1873) <400> 202 t gga aac aaa gaa gta ttt tcc tgc aga gga ata aaa ttg gca gtg gat 49 Gly Asn Lys Glu Val Phe Ser Cys Arg Gly Ile Lys Leu Ala Val Asp 1 5 10 15 tgg ttt ttg gaa aga ggc cac aaa gac att aca gtt ttt gtt cct gct 97 Trp Phe Leu Glu Arg Gly His Lys Asp Ile Thr Val Phe Val Pro Ala 20 25 30 tgg agg aaa gag caa tcc cga cct gat gct ctc att aca gat cag gaa 145 Trp Arg Lys Glu Gln Ser Arg Pro Asp Ala Leu Ile Thr Asp Gln Glu 35 40 45 att tta cgt aaa tta gag aag gag aaa atc ctg gtg ttc acg cca tcc 193 Ile Leu Arg Lys Leu Glu Lys Glu Lys Ile Leu Val Phe Thr Pro Ser 50 55 60 cgg cga gtc cag ggg agg aga gtg gtg tgc tat gac gac agg ttc atc 241 Arg Arg Val Gln Gly Arg Arg Val Val Cys Tyr Asp Asp Arg Phe Ile 65 70 75 80 gtg aag ctg gct ttt gag tcg gac ggt atc att aat gat aac 289 Val Lys Leu Ala Phe Glu Ser Asp Gly Ile Ile Val Ser Asn Asp Asn 85 90 95 tac agg gac ttg gct aat gag aag cca gaa tgg aag aag ttc ata gat 337 Tyr Arg Asp Leu Ala Asn Glu Lys Pro Glu Trp Lys Lys Phe Ile Asp 100 105 110 gaa cga tta tta atg tat tca ttt gtc aat gac aag ttc atg ccc cct 385 Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp Lys Phe Met Pro Pro 115 120 125 gat gac cct ctt ggc aga cat ggc ccc agt ctg gat ttt ctg agg 433 Asp Asp Pro Leu Gly Arg His Gly Pro Ser Leu Asp Asn Phe Leu Arg 130 135 140 aag aaa cct att gtt cct gaa cac aaa aag cag cct tgt cca tat gga 481 Lys Lys Pro Ile Val Pro Glu His Lys Lys Gln Pro Cys Pro Tyr Gly 145 150 155 160 aag aag tgt acc tat gga cac aag tgc aaa tat tac cat ccc gaa agg 529 Lys Lys Cys Thr Tyr Gly His Lys Cys Lys Tyr Tyr His Pro Glu Arg 165 170 175 ggc agt cag cca cag cgg tca gtg gct gat gaa ctc cgt gcc atg tct 577 Gly Ser Gln Pro Gln Arg Ser Val Ala Asp Glu Leu Arg Ala Met Ser 180 185 190 aga aat acg gca gcc aaa act gca aac gaa gga gga ctg gtg aaa agc 625 Asn Thr Ala Ala Lys Thr Ala Asn Glu Gly Gly Leu Val Lys Ser 195 200 205 aac agt gtt cct tgt agc acc aag gct gat agc act tct gat gtc aaa 673 Asn Ser Val Pro Cys Ser Thr Lys Ala Asp Ser Thr Ser Asp Val Lys 210 215 220 cga ggt gct cca aag agg caa tca gat cca agc ata agg aca caa gtc 721 Arg Gly Ala Pro Lys Arg Gln Ser Asp Pro Ser Ile Arg Thr Gln Val 225 230 235 240 tac caa gac cta gaa gaa aag ctt ccc acc aaa aac aaa ttg gaa acc 769 Tyr Gln Asp Leu Glu Glu Lys Leu Pro Thr Lys Asn Lys Leu Glu Thr 245 250 255 agg tct gta cct tcc tta gtt agc atc cca gct act tct act gca aaa 817 Arg Ser Val Pro Ser Leu Val Ser Ile Pro Ala Thr Ser Thr Ala Lys 260 265 270 ccc caa agc act aca tct tta agc aat ggc ctt cca tct gga gtt cat 865 Pro Gln Ser Thr Thr Ser Leu Ser Asn Gly Leu Pro Ser Gly Val His 275 280 285 ttc cca cct cag gat caa aga cca cag gga caa tat cct tca atg atg 913 Phe Pro Pro Gln Asp Gln Arg Pro Gln Gly Gln Tyr Pro Ser Met Met 290 295 300 atg gca acc aaa aat cat gga acg cca atg cct tat gaa cag tat cca 961 Met Ala Thr Lys Asn His Gly Thr Pro Met Pro Tyr Glu Gln Tyr Pro 305 310 315 320 aaa tgt gac tca cct gtc gac atc gga tat tat tcc atg ttg aat gca 1009 Lys Cys Asp Ser Pro Val Asp Ile Gly Tyr Ty r Ser Met Leu Asn Ala 325 330 335 tac tca aat ctg agt ctc tca ggc cca cga agc cct gaa agg cgt ttc 1057 Tyr Ser Asn Leu Ser Leu Ser Gly Pro Arg Ser Pro Glu Arg Arg Phe 340 345 350 350 tcc tta gac aca gat tat aga ata agt tcc gta gct tct gac tgc agc 1105 Ser Leu Asp Thr Asp Tyr Arg Ile Ser Ser Val Ala Ser Asp Cys Ser 355 360 365 agt gaa ggg agc atg agc tgt ggg agc agt gac tcc tac gtg ggt tac 1153 Ser Glu Gly Ser Met Ser Cys Gly Ser Ser Asp Ser Tyr Val Gly Tyr 370 375 380 aat gac cgg tcc tat gtc agc tcc ccc gac cca cag cta gag gag aat 1201 Asn Asp Arg Ser Tyr Val Ser Ser Pro Asp Pro Gln Leu Glu Glu Asn 385 390 395 400 ttg aag tgt caa cac atg cac cct cac agc cgc ctt aat cct caa ccg 1249 Leu Lys Cys Gln His Met His Pro His Ser Arg Leu Asn Pro Gln Pro 405 410 415 ttc ctg cag aat ttc cac gac ccctta acc aga ggg caa agt tac agt 1297 Phe Leu Gln Asn Phe His Asp Pro Leu Thr Arg Gly Gln Ser Tyr Ser 420 425 430 cac gaa gaa cca aag ttc cat cac aag cct cct ctt ccg cac ctg gct 1345 His Glu Glu Pro Lys Ph e His His Lys Pro Pro Leu Pro His Leu Ala 435 440 445 ctg cac ctg ccg cac tcc gct gtg ggc gcc cgg tcc agc tgt cct ggc 1393 Leu His Leu Pro His Ser Ala Val Gly Ala Arg Ser Ser Cys Pro Gly 450 455 460 gac tac ccc tct cct cca agt tca gca cac tct aag gca cca cac cta 1441 Asp Tyr Pro Ser Pro Pro Ser Ser Ala His Ser Lys Ala Pro His Leu 465 470 475 480 ggg agg tcc ttg gtg gcc acg aga ata gac agc atc tct gac tct cga 1489 Gly Arg Ser Leu Val Ala Thr Arg Ile Asp Ser Ile Ser Asp Ser Arg 485 490 495 ctt tat gac agt tct cct tca cga caa aga aag aag cct tat tcc cgc cag 1537 Leu Tyr Asp Ser Ser Pro Ser Arg Gln Arg Lys Pro Tyr Ser Arg Gln 500 505 510 gaa ggc ctg gga agc tgg gag agg cca ggc tat ggg atc gac gcc tat 1585 Glu Gly Leu Gly Ser Trp Glu Arg Pro Gly Tyr Gly Ile Asp Ala Tyr 515 520 525 ggg tac cgg cag tat tcc ttg ccc gat aac tcc aca cag ccg tgt 1633 Gly Tyr Arg Gln Thr Tyr Ser Leu Pro Asp Asn Ser Thr Gln Pro Cys 530 535 540 tat gag cag ttc acc ttc cag agc ctc cct gag caa cag gag cca gcc 1681 Glu Gln Phe Thr Phe Gln Ser Leu Pro Glu Gln Gln Glu Pro Ala 545 550 555 560 tgg cgg atc cca tac tgt gga atg ccg caa gat ccc ccg agg tat caa 1729 Trp Arg Ile Pro Tyr Cys Gly Met Pro Gln Asp Pro Pro Arg Tyr Gln 565 570 575 gac aac cga gaa aag att tat atc aat ttg tgc aac atc ttc ccc cct 1777 Asp Asn Arg Glu Lys Ile Tyr Ile Asn Leu Cys Asn Ile Phe Pro Pro 580 585 590 590 gac ctt gtg agag attgt aat cct cac atg aca gac gcc 1825 Asp Leu Val Arg Ile Val Met Lys Arg Asn Pro His Met Thr Asp Ala 595 600 605 cag cag ctc gcc gca gcc att tta gtg gag aaa tcc cag ctg ggt tat 1873 Gln Gln Leu Ala Ala Ala Ile Leu Val Glu Lys Ser Gln Leu Gly Tyr 610 615 620 tgaaagatga tgcatctttg tggtgtttag tagttttttg ttcagctcaa atgctgaggg 1933 aggtttgcta caatagcaca tgtgatctcc ttctcagcaa ggaggttata tagtatccat 1993 ttatgtgaaa tactgtatca tggaatctgt atgtatagcc ccacatggtg gaagtatcac 2053 gggattgctt tacatttaaa cttttttttt tttaacattt cctttttaaa gctatatcct 2113 tggctggaaa tttttccagt ttgatttaat agatgtatct gtgatctttg atat taatct 2173 ttggtgcatc aggggtttat atgcagcact ttttatcctt gttttgtgtt ttattaactt 2233 ggtgtttgtc tatcaattgc aagcaattac aataccttca gaatgtggga catttgacta 2293 gacctagcaa actgtttttt cgagccaagc ttagttagac tcttttacag ctttttaagt 2353 tatttttatt tggggaaagt gggcttcttt gtgctataat cattatttat agaaacaaag 2413 ttatactaca gcactgactt tatattttaa acagaatgta agttaccagt tttatgttga 2473 aatgtgttac agtatatata tattagaatg atttacaata tggcactttt cgatgtgtta 2533 tttttgtttg gatttttttt tctgttaaga aattagttaa tttaatatgg tcaatttaaa 2593 agaaagcaga tgcaatcaat ggaaaaatgt ttccattttt taaaaatgaa taaggcaaaa 2653 gctgtaactg ttacaggtta gagctttgtt atccagctat gatgtgcttc ttgacagtag 2713 aagtggaatt gaattcctag atttccatta acctgtattt ttaatatgtc tgtctttttg 2773 ttttggggca caacaatact ggataaaata accctttcac agcacttgcc tgtttttaat 2833 gaatctaatt attcacaatg caacttttat atttaacata ctctttagct ttcctgctat 2893 ttatcaaggc tggcctgagg tgggtttatg tgttgaggtt atgcaacatt tcttgatact 2953 gcactataga gaaatggtga tggaggagtt gtaaatggta acttaaaatt tttgtaagat 3013 attgtatatt ttccattttc ctgaaggtag ttttcttggg ggggcctgtt atattattaa 3073 ggccagactc ttgccacaaa tagtgtagtt ttagatacag actaaggtct gttctagtat 3133 tagtaaggga tatttctggt ttcaaagtca tgggttttgc tagtggtgaa tacatttctg 3193 cggagtagaa gatagatttt gcagtcagtg gcagacagtt gtgtgattga catcacttga 3253 ctgttgcgtc caggttttga attgtacttc acgtaacaga tgcattcaga tctttttctg 3313 tagtctgctt agatgccctg gctattctga ttatcctaca tgctacagtt tgaagtgaag 3373 ccctgaaaaa ccagaaagta ccttttactg ttgatacaaa ttgtatcttt ttaactataa 3433 gaactatttt gatttgtaga tctagttaaa acacaagtat gtaactatga ttagactttt 3493 gggcaacatt ttatccctta tttaaataca aatttttaaa gtaaaattga ggtctagaat 3553 agattagaaa ataaaaataa caatttagat aaatagaaat gtctgtctta gttttatata 3613 atatattaaa acacagtaaa taaatttatt ggcattttct ttctcctaaa acttacctag 3673 tgtgaactta aaataaaggt aaaatgctgc ctgaaaataa tgtccaagca cctttgacta 3733 ggataacatt ttcactactt gtgtgacact gtgtgttgca cgaagtagga tttgggtata 3793 cagtaaatgc ttctaaaagg cattgtgcat attgacataa ccaataatct gaaccgtgtt 3853 cagcaaactt aattcaggaa agtggtattc tacacaatta ttgctgttgt gtttgaaatg 3913 agtgtggcac tcatctgtat ccagaaataa tatgggtgag gccacacaac ccattctgag 3973 tggtgtctgt ctgaaagcaa ccctactcgc atgtgaaatt gttctccttg atttggtcac 4033 tataaagcaa gtttaaatgt agaggctaac tcagtgccaa aaacagggtt acaaatgtgt 4093 agtatctttt attttagtca tattctaaga cttcttttta gtatgaaatc acttttaaat 4153 tatacatgta ggttttgctt ccattttctt cattttacca ttttaattat ttgaacattc 4213 gccaaatttt acatttattt aaatgagatc ttaggtgaga tgtgtgtgac actttgaatt 4273 tgaccttctt gtgttattag ctgactattt gtcattgcct catggatttt aaattatggg 4333 aaaatagtgt agccagctgc cacctctact gaagtgagta gctctgaact acccacacta 4393 aatccttcag tgtaattaat tatgagttta aaaatagcag ttttcttatg tgaagaggac 4453 agtttgtccc ctttttttga agcaccgatg ttgcgttcag agctgtagaa tgagataatt 4513 ggcagacttt aggtacagca aattcttact tatctaaagc aataagtcaa aggagtccat 4573 cattaaatta aatccatagc tgatcacaag ccttcatttt agccaaaact ttctctctaa 4633 ccaaatcttt taccagactt gctaataaat aaccagagag atgtgttaat aagtgaagtt 4693 gccag aaatg gtcaactgat cggaaaaaaa aggattcaga ctggagtatt ttgcccctga 4753 ataattgaca gttgactgtg ctttacacag taactagcca gtctgttgtc tctgtgtctt 4813 agtccagagg gaatagtacc caattggcca aatactggcc cttagtatct cctcctttct 4873 tgcatgggat acagacgttt tcagtcttgt ttttatgatc tctctctata tcctgataag 4933 agtttgtcat tgacttacac atttggaaga aatgcacacc agtgtaatat atttgatact 4993 ggtggaaact tgaactttgt gtttttatga aaattcattt atgagaatat gtaatataac 5053 tgaagagtat tttatgtata tctatataca caaatatgta tttgttatga ggtattaaaa 5113 acaggggttg gggggagtgc ttctgatggc taacttttct ctaattaaac tatgtttctt 5173 tgagttgtga acgaccgagt ctggggtctg gacggccaat gataagattt agaaccactt 5233 ggatggaaag cagttcttca ctggttttat tcttggtatt ttcaaagaat tattttgata 5293 tttttaatag aatgtgtaat tttaaaatac acaaaaaact taaagtagta ttgattatac 5353 aaataattat ttaacatgtc ttatggatgt atctatatgt atatagacag taatatattt 5413 ataaaacaaa tatactttgc ttatgttata gctcttagtt tgtgacaggt gggaggatgg 5473 ctctgggtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tttgaaaact 5533 ctcaagctgt tttccctctg atttacaatg gtatttactt taaagtatgt ttggttttca 5593 ttattctttt tgctctccaa cttccttatt caagataaaa taagacatac agttttctgg 5653 ccattctgtt ggtgtgtggt gcacccattt tattgtcatc taactcctgg agaattccca 5713 cgtgacctga aatcaaacag attctggctg gacatatgct tatgttccaa atatattaaa 5773 gatgttaatt cagctaacag ttaagtttcc aaggtataca ccaacaaata aaatgaggta 5833 ttaaaaagag atggattaca cacatgcatt agaataagag aaaacagtag tgttaataaa 5893 agtaaagaaa catacactat cttagccccc tagggcaggg gttgactttt tctgtaaagg 5953 atcagatagt aaataataca ggaatcatat ggacttcaaa tgccattgta aaaactactc 6013 agctctgcct ttagagcata agaacagcca cagataacat gtaaattagt gtggctgtgt 6073 tccaataaaa ctttatttac agaaacggga agccggtcag attgggcctg tgggccataa 6133 tttgctgatc tcaagcagta aatcctggta tatgttaata gaagaaatca taattgcatt 6193 tcagttgaca ttaaaagaaa atctggtagt ttttgatgtc cttcaaaaga ggattgttag 6253 acattgatgt taaagcatct taattcattt gagttttctt acctgtttac acccattatt 6313 tattagagat atttcttgtg tttaaccaca aaaaaaagca ctctgttaaa atgttttaat 6373 atgtattgaa tttc tttcat aaacttttca tttctgttga taaatgggaa tcccttacca 6433 accttttgtt ttttaaaagt ctcatagacc aaaaaaaatc tgttgcagca tttaattagc 6493 cacagataca ttttggctgc atttaccagt tacatttttc cattggtttt ggcttctaat 6553 aaataacata tctgccattc cttaaaaatg attttaaaga agataaatat attgtaattt 6613 cacatgctat agctttattc tgtaagatta aaaattgtga ctagtataat tgtagctata 6673 atgtgagtgg catgttacaa tgtaactctt tatgagaaat aaaatgtatc tctgctttgt 6733 ctgtccagat ctttaggatt tttagatgcc ttgggactgt ccttggtgaa tgatattctt 6793 catatgatca tatgtaattt tgaattcgtt ggaagtacac gctgctgagc atgtttattc 6853 acagtgcttt ataccgggtg ttgcatcagt aatcattttc ataagaacat ttaaacagca 6913 tgaacatcat catccactta aatagttaaa ctttctttta aaattggaat gcaactgtag 6973 gttttaacaa tgtttattgt tttttaagtg gttactttgt ttttccttaa tactttctgt 7033 taacttaatt attactcctg ttgcagtgtt actgttatgt attagaagtg gcttttcccc 7093 ctaagatcct tagtctttta aagacaattt aaggtattgg ccatttggca gtagaaaatg 7153 tgcatgtttt aacttggttt tataaaatct gtaatgtttc acttcttgaa ccatgtacca 7213 aatttgccaa ttttctgtcc aagtgtttca gatgaataac aaaacgctgt tcattgaagc 7273 tttcgccacc tttcttaaag cagcgtatgt tccaagggaa aaaggcattg aaaagcaatc 7333 gtttgttttt atgaagaata ggtgttcaga ttccttcagt ttttttgaaa ttagaaattt 7393 cttaccttat gtgaaatatt cacaaacgtg cacacttctg cagagacaaa gcatttcact 7453 gcacgtgtac caggttattg attttatctt ttcctttcag ggttttgtcc tcccaaacca 7513 gagtcatatg ctgctagtag aattttttat ttgatcctgc gaacttttct tataggaaaa 7573 gtaaggcaaa ggatgtgtag tgcaaccatc tgataaacta gtgtgattgt atttatcctc 7633 tgttctgtgt atttctgtaa tggaatcttt acaattccca aaacggtatt ttagacctac 7693 tggaaatctg tatcgaaaca gctatgtgat tctgccactg agaaaaaaaa aatttttaat 7753 tcgtttttct tatgctggtt tgtttttctt taatgaagaa attgatctca tatggcatca 7813 tagatgctaa ataaataaaa gcatcatact tctctagttt gcctgcattc agtggctaac 7873 attatgagca ttgtgtaaga taaacacatg gtcagtatca atgtaaatgt tagagccatg 7933 attaattcct atgaaaattg aaattaaatg tcaaagacaa ctagacat 7981 <210> 203 <211> 7173 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (85) .. (1740) <400> 203 cccgagagca gcatctctca ccgtttccac aaagactgtg cctctcgagt caataacgcc 60 agctattgtc cccactgtgg gtag gag agc tcc aag gcc aaa gag gtg acg 111 Glu Ser Ser Lys Ala Lys Glu Val Thr 1 5 ata gct aaa gca gac acc acc tcg acc gtg aca cca gtc ccc ggg cag 159 Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly Gln 10 15 20 25 gag aag ggc tcg gcc ctg gag ggc agg gcc gac acc aca acg ggc agt 207 Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly Ser 30 35 40 gct gcc ggg cca cca ctc tcg gag gac gac aag ctg cag ggt gca gcc 255 Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala Ala 45 50 55 tcc cac gtg ccc gag ggc ttt gat cca acg gga cct gct ggg ctt ggg 303 Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu Gly 60 65 70 agg cca act ccc ggc ctt tcc cag gga cca ggg aag gaa acc ttg gag 351 Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu Glu 75 80 85 agc gct ctc atc gcc ctc gac tcg gaa aaa ccc aag aag ctt cgc ttc 399 Ser Ala Leu Ile Ala Leu Asp Ser Glu Ly s Pro Lys Lys Leu Arg Phe 90 95 100 105 cac cca aag cag ctg tac ttc tcc gcc agg caa ggg gag ctt cag aag 447 His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln Lys 110 115 120 gtg ctc ctc atg ctg gtg gac gga att gac ccc aac ttc aaa atg gag 495 Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met Glu 125 130 135 cac cag aat aag cgc tct cca ctg cac gcc gcg gca gag gct gcac His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly His 140 145 150 gtg gac atc tgc cac atg ctg gtt cag gcg ggc gct aat att gac acc 591 Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala Asn Ile Asp Thr 155 160 165 tgc tca gaa gac cag agg acc ccg ttg atg gaa gca gcc gaa aac aac 639 Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala Ala Glu Asn Asn 170 175 180 185 cat ctg gaa gca gtg aag tac atc aag gct ggg gcc ctg gtg gat 687 His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly Ala Leu Val Asp 190 195 200 ccc aag gac gca gag ggc tct acg tgt ttg cac ctg gct gcc aag aaa 735 Pro Lys Asp Ala Gl y Ser Thr Cys Leu His Leu Ala Ala Lys Lys 205 210 215 ggc cac tac gaa gtg gtc cag tac ctg ctt tca aat gga cag atg gac 783 Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn Gly Gln Met Asp 220 225 230 gtc aac tgt cag gat gac gga ggc tgg aca ccc atg atc tgg gcc aca 831 Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met Ile Trp Ala Thr 235 240 245 gag tac aag cac gtg gac ctc gtg aag ctg ctg ctg gag ggc tct 879 Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu Ser Lys Gly Ser 250 255 260 265 gac atc aac atc cga gac aac gag gag aac att tgc ctg cac tgg gcg 927 Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala 270 275 280 gcg ttc tcc ggc tgc gtg gac ata gcc gag atc ctg ctg gct gcc aag 975 Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu Leu Ala Ala Lys 285 290 295 tgc gc gtg aac atc cac gga gac tcg cca ctg cac att 1023 Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser Pro Leu His Ile 300 305 310 gcc gcc cgg gag aac cgc tac gac tgt gtc gtc ctc ttt ctt tct cgg 1071 A Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu Phe Leu Ser Arg 315 320 325 gat tca gat gtc acc tta aag aac aag gaa gga gag acg ccc ctg cag 1119 Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu Thr Pro Leu Gln 330 335 340 345 tgt gcg agc ctc aac tct cag gtg tgg agc gct ctg cag atg agc aag 1167 Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu Gln Met Ser Lys 350 355 360 gct ctg cag gac tcg gcc ccc gac agc ccc gtg gag agg ata 1215 Ala Leu Gln Asp Ser Ala Pro Asp Arg Pro Ser Pro Val Glu Arg Ile 365 370 375 gtg agc agg gac atc gct cga ggc tac gag cgc atc ccc atc ccc tgt 1263 Val Ser Arg Asp Ile Ala Ag Gly Tyr Glu Arg Ile Pro Ile Pro Cys 380 385 390 gtc aac gcc gtg gac agc gag cca tgc ccc agc aac tac aag tac gtc 1311 Val Asn Ala Val Asp Ser Glu Pro Cys Pro Ser Asn Tyr Lys Tyr Val 395 400 405 tct cag aac tgc gtg acg tcc ccc atg aac atc gac aga aat atc act 1359 Ser Gln Asn Cys Val Thr Ser Pro Met Asn Ile Asp Arg Asn Ile Thr 410 415 420 425 cat ctg cag tac tgc gtg tgc atc gac gac tgc tcc tcc a gc aac tgc 1407 His Leu Gln Tyr Cys Val Cys Ile Asp Asp Cys Ser Ser Ser Asn Cys 430 435 440 atg tgc ggc cag ctc agc atg cgc tgc tgg tac gac aag gat ggc cgg 1455 Met Cys Gly Gln Leu Trp Arg Tyr Asp Lys Asp Gly Arg 445 450 455 ctc ctg cca gag ttc aac atg gcg gag cct ccc ttg atc ttc gaa tgc 1503 Leu Leu Pro Glu Phe Asn Met Ala Glu Pro Pro Leu Ile Phe Glu Cys 460 465 c gac g tgc tgg agg aac tgc cga aat cgc gtc gta cag 1551 Asn His Ala Cys Ser Cys Trp Arg Asn Cys Arg Asn Arg Val Val Gln 475 480 480 aat ggt ctc agg gca agg ctg cag ctc tac cgg acg cgg gac atg gg Leu Arg Ala Arg Leu Gln Leu Tyr Arg Thr Arg Asp Met Gly 490 495 500 505 tgg ggc gtg cgg tcc ctg cag gac atc cca cca ggc acc ttt gtc tgc 1647 Trp Gly Val Arg Ser Leu Gln Asp Ile Pro Pro Gly Thr Phe Cys 510 515 520 gag tat gtt ggg gag ctg att tca gac tca gaa gcc gac gtt cga gag 1695 Glu Tyr Val Gly Glu Leu Ile Ser Asp Ser Glu Ala Asp Val Arg Glu 525 530 535 535 gaa gat tct tac ctc ttt gat ctc ac aat aag atc tcc tcg gct 1740 Glu Asp Ser Tyr Leu Phe Asp Leu Asp Asn Lys Ile Ser Ser Ala 540 545 550 tagcagctga agactgacgc tgcctgatcg catcccctag gaagccccct ggatcatcac 1800 ggacgccgag cttcgggtaa ctcttatggt ggagggggaa aacgtccaga aacaaatgaa 1860 tcctcaggtc tggaactcag gagaagactc tggactgagc tatggatctg gaaactcctg 1920 aacagagcag tggttccaag ctggagacga ttttgcacct gggggacgtc tgcaaggtct 1980 ggagacagtt tgggttgtca caaccgaagg agtgctatgg cacttagtgg gatcaggcag 2040 ggatgttgtt aaacactgta cagtgcacag gacagccctc cccaacagag ttcctggacc 2100 gtacatgtta atggtgctgg ggctgagagg ccactgatgg actcgtggag ctggcgaggc 2160 ggccctggag tctgtggcct gtgagggaag cgggaacctc tgagggagtg cagcgttcag 2220 cagcatccac ccatccagcc acgaggcctg gcagaggggt gggagaggag gtggacctgc 2280 cgtagacccc acaagcctgt caaggagctg ggacttggag tgaaaaggag agcgacgtgg 2340 tcagaactgt gccttagaaa gaccactctg gacacagaga gggggctggg gagaggcgag 2400 ggctgcatgg tgctgtggct gcctgctgga atggcaggct aggccattgt gggcagcagt 2460 gagggaaggg gtgattcggg agctggaaga ggcaggacag ggcaacgggc tggacttgat 2520 gggtgagaga agctagtgac ctttggcatg tagcaaacag ttctcatgcc ctgccaccag 2580 catcatgcca gggcaggctg ggctctcacc ctcacagaat gtcccatgaa taattatgta 2640 actaaaagtg ctgtgtgttg caggtagcaa ctaaccgggg ctggtggcgt gggcagtaaa 2700 aagaatttac caagactgtt gtaggtaaag aaaggcagat ttatgagaga aagtaggaaa 2760 atacgttgca agaaagcaat gggcaatcac caagagaggc gctggcagca agagctgaag 2820 gcgtgctggg gattttatag gatggggctt gtgccggaga gggccatgtg cagtgctgat 2880 aacgcccagg ttgcagggag ctaacgcgtt tttctatcag ccgaggatct ggtgataact 2940 gggcgtagga agattgtgat ttgtctgcac gggagggccg tgtgtcctgg accatgaaga 3000 aaggcagact cacagcttct ccgctctctc tgttgctttc ccctggtccc accagtctga 3060 ctcctttccc tcattaggac tccgcagcat ggacaccatg aagggaggca gagcctgtga 3120 caggaacgct cagccaggga ggcttctctg atgagggcca gagctgtcca ggccaggcct 3180 ggggggacag acgcacattc acgttcaagg ttttatttga acatggtttc aatgaatcct 3240 ctcaatgttt tgaaattgca acttagtttc agtcgtctac aaaacctttg ctcccccgta 3300 gcagcacccc ctttatgttg ttattatcac aaattacatc ttgac acact gggccaccag 3360 caggacttat aattattgta ataggcagtt gtctctttaa attgcaaggc acttacagcg 3420 aaggtgcctg catgctccct ctagtccccc agggaagcag cccgagcccc tgggaagggc 3480 caggtattaa cttgccagac atcgcagctc attccaggct cccagccact cttccgtcag 3540 tggattccaa ttctgaaaat cggctcatgt ccagaaacag cacgggagtg tgacttcctg 3600 ctggggcagc ccctcagccc ctgccctctg ttgactctta catgtgaagc ttcccccttg 3660 ttggccactg gtttcacccc tcagggcacc gtgctctgtt accaccccct gttactgccc 3720 ccaggcccct cggtggccgc ctgcctcatc ttccccacgg ggattaggga gcccggctct 3780 gtagctgcgt ctcccatcat cagcacaggc tgcagagggg gaacccctcg actctcccac 3840 cctcagcaca ggctgcagat ggggaacccc tcaactctcc caccctcagc acaggctgca 3900 gacggggaac ccctcgactc tcccaccctc agcacaggct gcagaggggg aacccctcga 3960 ctctcccacc ctcagcacag gctgcagacg gggaacccct cgactctccc accctcagca 4020 caggctgcag acggggaacc tcttgactct cccaccctca gcacaggctg cagacgggga 4080 atgcctcgac ttcctggtga tgctggtgtt ctccctaggg cttcctgcac acccacctcc 4140 ctccacccca ttccttcctc taccagctgt cagagaactt gagggtttct gcttcactgt 4200 gagctggcta ccactttttt caaggctttt aagagccatt ccaagttttc cccacctcct 4260 gggtcctgag aaagtgcccc actgcagcaa atgcttccag acccttggtc aagctcctca 4320 ctctcccatc ccgggacttc tcttctgccc cagctgaggc catcaaccag ttcttgcaat 4380 tacttagctg tgcagcccct ttctcccttt ttaggcttag caccctgccc cttcccgttg 4440 gtctgtgctg ggatttagcc ctcgcaattg gcctggcagg caggtgggac agctcctgag 4500 gcgagcactt gcttcctggt gagacaggtg attccgtaac atctccagca cagtagatgt 4560 gctcaccttt atggggcagg aggacctgtg cacttccaga ggttccagag gactggaggg 4620 tcctcatcgt tacatctttg ggacccagat tttccccagg ggacccttac tttctacctt 4680 tgcagagctg acccaccggt ggcccttcac tctggttaag tgcctgttta cctctgtggt 4740 agaggcactc cagtctcaca ccgagcttgg taacagttct caggatgtcg gtatggggaa 4800 ccagcccgct gtcctgtctt tgttggtttg gttgctcccc actcccagtt tttcaggggc 4860 ctgcatcatc ccaccagcca cagcgctgtg ctccaccgag atattttccc aggtcatcac 4920 tcatgaagct cccaccgtgt gccagggacc accggacctc ccagccaacc aggacagcag 4980 cctctgcacc ctttgggtgg tgggcaggac agtcccagat cctctcctga tgcca cttat 5040 gttagtccag gtcttccaag atgcagatgg gataaaggta taaggatttg gttagatttt 5100 attagatgat gaaggctgag tgtggtggct cgtgcctgta atcccagcac tttgagaggc 5160 caaggtgggc agatcacttg aactcaggag ttcgaggcca gcctgggcaa catggtgaaa 5220 caccgtctca acaaaaacaa acaaacaaaa attagcctgg catggtggtg tgtgcctgta 5280 gtccttgcta cctgggaggc tggaatggga gggttgcttg agtccaggag gtggaggttg 5340 cagtgagccg agatcatgcc cctgtactgc agcctaggtg atgggaatga agccctttca 5400 aaaaaagaga gaagatttta ttagatgatg aagattagat attgttgtta ttattagaga 5460 tgaagcatgg aggtagctaa gaaacttgga agagcttcag aatgtgagta gctctaactt 5520 ccagagagga agagagggaa cgaaggttga ctgggagtga cctagatcac taaacaacct 5580 aaggaaggtt caggaaagct gccagggagt tcttgagcca aagaagtgtg gcctcagcac 5640 aaatgcagag acagattctg agcacaagag ctgaggccat tggtcatgac attcccatag 5700 ttggaggcct atgaagcaca ctttcaagga aactgcaact gtttaaaata acagtaatgt 5760 cctatgtgtg ttttttttaa aagaaaggct gaaagttaat tagctcatca tccacccgaa 5820 gaagcaaaat caacctaaaa caagaggtat aaagagaagc actaattaga tagaaactaa 5880 catgcactgg agacaatcaa accaaaactg gttctttggc aacactaatc agaatggcaa 5940 ccctctgggc aggtggggaa gggggagcat aaataaacaa tttaaaggtg ggccaggtgc 6000 agtggctgac acctgtaatc ccagcacttt gggaggctga ggtgggagga tcacttgagc 6060 ccaggagttg gagaccagcc tgggcaacat agcaagaccc tgtctctgga aaaaatttaa 6120 aaactagctg gacatggtgg catgcacctg tgatcccagc tactcgggag gctgaggtgg 6180 gaggctggct tgagcctggg aggttgaggc tgcagtgagc tgagattcta ccactgcagt 6240 ccagtctggg tgacagagca agaccatgtc tcaataaata aataaataaa taaataaata 6300 aataaagtgg acacagccat agatataaca tagatttaaa agataatatg aacaatttta 6360 ggccaataca tttctagaaa aatataactg cactaacact gactcaagag gaaatagaga 6420 acccgaatag tcttataact cttaaagaga tagaatcagt aattaaaatc acaaacaaaa 6480 catcaggccc agtcagtgag ttccactgaa ctttcaaaat ataaattccc tatagaaatg 6540 ctctctaact catttacaag gctagcataa cctggatatc caaacctgat gagaatagtg 6600 cagtgcacag ctgcaaaaag tctagacaag ttattggtaa accagatctg aattgtacgc 6660 aaagatgatt atgtttgatt taccccagga atgacaggtt ggtttaactt taggaaatca 6720 gtttatgtaa gccattccct taacacatag aaggagaaaa attaggtcat ttcaatgcag 6780 aaaaagcatt tgacagaatt tatcacctat tcgtgagaaa aactcctaga aattaagact 6840 agaggggaac tttgtgacct gatgaacggt atcttttgaa caaaaaaaaa aagaacaggc 6900 ctggcgcagt ggctcatgcc tgtaatccca gcactgtggg aggccaaggt gggcagatca 6960 ccctgaggtc agtagttcaa gaccaacatg gcaaaacccc atctctacta aaagtacaaa 7020 aattagccag gtgtggtggc acgcgcctat aatcccagct actcaggagg ctgagacagg 7080 agaattgctt gaacctggga ggtggtggag gttgcagtga gctgagatag tgccactgca 7140 cttcagcctg ggcaacagat cgagatttcg tct 7173 <210> 204 <211> 6356 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3391) <400> 204 a gaa aat ggg aat att gcc aca gca cct gga ttc atg att ggg cag aca 49 Glu Asn Gly Asn Ile Ala Thr Ala Pro Gly Phe Met Ile Gly Gln Thr 1 5 10 15 cct cct cca gca cct cct cca cct cct cct cca ccc cct cca tct cca 97 Pro Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Pro 20 25 30 cca tgt tca tgt tca agg gaa gag tgt cct tcc tcc cct cct cca ccc 145 Pro Cys Ser Cys Ser Arg Glu Glu Cys Pro Ser Ser Pro Pro Pro 35 40 45 cca cca cct cca ctt cct ggg gag cct ccc atc cca cct ccc cca cca 193 Pro Pro Pro Pro Leu Pro Gly Glu Pro Pro Ile Pro Pro Pro Pro 50 55 60 ggc cta ccc cca act act cac atg aac ggc tac agc cac ctt ggt aag 241 Gly Leu Pro Pro Thr Thr His Met Asn Gly Tyr Ser His Leu Gly Lys 65 70 75 80 aaa aag cgg atg aga agc ttt ttt tgg aaa act att ccg gag gag caa 289 Lys Lys Arg Met Arg Ser Phe Phe Trp Lys Thr Ile Pro Glu Glu Gln 85 90 95 gtt cga ggc aaa acc aac atc tgg acc ttg gca gcc agg cag gaa cat 337 Val Arg Gly Lys Thr Asn Ile Trp Thr Leu Ala Ala Arg Gln Glu His 100 105 110 cac tac caa att gat aca aag acc att gag gag ctc ttt ggg cag cag 385 His Tyr Gln Ile Asp Thr Lys Thr Ile Glu Glu Leu Phe Gly Gln Gln Gln 115 120 125 gaa gac acc acc aag tct tcc ctt cct agg aga gga aga act tta aat 433 Glu Asp Thr Thr Lys Ser Ser Leu Pro Arg Arg Gly Arg Thr Leu Asn 130 135 140 tca tcc ttc aga gaa gct cga gaa gag att act att ttg gat gca aaa 481 Ser Ser Phe Arg Glu Ala Arg Glu Glu Ile Thr Ile Leu Asp Ala Lys 145 150 155 160 cgg agc atg aac att ggg ata ttt ctt aag caa ttt aag aag tct cct 529 Arg Ser Met Asn Ile Gly Ile Phe Leu Lys Gln Phe Lys Lys Ser Pro 165 170 175 cgg tcc att gta gaa gat att cat caa gga aaa agt gag cat tat gga 577 Arg Ser Ile Val Glu Asp Ile His Gln Gly Lys Ser Glu His Tyr Gly 180 185 190 tca gag acc ttg cga gaa ttt ctt aag ttt ttg cca gag tca gaa gag 625 Ser Glu Thr Leu Arg Glu Phe Leu Lys Phe Leu Pro Glu Ser Glu Glu 195 200 205 gta aag aag tta aaa gcg ttt agt ggc gac gtg tcg aag ctg tct ctg 673 Val Lys Lys Leu Lys Ala Phe Ser Gly Asp Val Ser Lys Leu Ser Leu 210 215 220 gca gat tcc ttt ctg tat ggc tta att cag gtg cca aac tat tca ctt 721 Ala Asp Ser Phe Leu Tyr Gly Leu Ile Gln Val Pro Asn Tyr Ser Leu 225 230 235 240 cgg att gaa gcc atg gtg cta aag aag gaa ttt cta cct tct tgc tct 769 Arg Ile Glu Ala Met Val Leu Lys Lys Glu Phe Leu Pro Ser Cys Ser 245 250 255 tct cta tat aca gat ata aca gtt tta aga act gct ata aaa gaa ctg 817 Ser Leu Tyr Thr Asp Ile Thr Val Leu Arg Thr Ala Ile Lys Glu Leu 260 265 270 atg tca tgt gaa gag cta cat tca ata tta cac ttg gtg ctc cag gct 865 Met Ser Cys Glu Glu Leu His Ser Ile Leu His Leu Val Leu Gln Ala 275 280 285 ggg aat atc atg aat gca gga ggg tat gcc ggc aat gca gta gga ttt 913 Gly Asn Ile Met Asn Ala Gly Gly Tyr Ala Gly Asn Ala Val Gly Phe 290 295 300 aaa ctg tct tct ttg ctc aaa ttg gca gac aca aaa g cct 961 Lys Leu Ser Ser Leu Leu Lys Leu Ala Asp Thr Lys Ala Asn Lys Pro 305 310 315 320 ggg atg aat ctc ctg cac ttt gtt gca cag gaa gcc caa aag aaa gat 1009 Gly Met Asn Leu Leu His Phe Val Ala Gln Gl u Ala Gln Lys Lys Asp 325 330 335 acc att ctt cta aac ttt tca gaa aaa ttg cat cat gtt cag aag act 1057 Thr Ile Leu Leu Asn Phe Ser Glu Lys Leu His His Val Gln Lys Thr 340 345 350 gct aga tta tct ctg gag aac acg gag gca gaa ctg cac ttg ctg ttt 1105 Ala Arg Leu Ser Leu Glu Asn Thr Glu Ala Glu Leu His Leu Leu Phe 355 360 365 gtc agg aca aaa tca cta aaa gaa aac atc cag cgg gat ggt gaa ctt 1 Thr Lys Ser Leu Lys Glu Asn Ile Gln Arg Asp Gly Glu Leu 370 375 380 tgt cag cag atg gaa gat ttt ctt cag ttt gcc ata gaa aag ctg agg 1201 Cys Gln Gln Met Glu Asp Phe Leu Gln Phe Ala Ile Glu Lys 385 390 395 400 gaa ctg gaa tgc tgg aaa caa gag ctc cag gat gag gcc tac acc ctt 1249 Glu Leu Glu Cys Trp Lys Gln Glu Leu Gln Asp Glu Ala Tyr Thr Leu 405 410 415 ata gat ttt ttc tgt aaa acc atg aaa ctg gat gaa tgc 1297 Ile Asp Phe Phe Cys Glu Asp Lys Lys Thr Met Lys Leu Asp Glu Cys 420 425 430 ttt cag ata ttt aga gat ttc tgt acc aaa ttc aac aaa gca gtt aag 1345 Phe Gln Ip Pg Phe Cys Thr Lys Phe Asn Lys Ala Val Lys 435 440 445 gac aac cac gac cgg gag gcg cag gag ctg agg cag ctg cag agg ctg 1393 Asp Asn His Asp Arg Glu Ala Gln Glu Leu Arg Gln Leu Gln Arg Leuag 450 460 gag cag gag cag aag cag cgc tcc tgg gca act ggg gag ctg ggg 1441 Lys Glu Gln Glu Gln Lys Gln Arg Ser Trp Ala Thr Gly Glu Leu Gly 465 470 470 475 480 gca ttt ggc cgg agc agc agt gag gat gat gg acc aag 1489 Ala Phe Gly Arg Ser Ser Ser Glu Asn Asp Val Glu Leu Leu Thr Lys 485 490 495 aag ggt gca gag ggc ctg ctc cct ttc ctg cac ccc agg ccc atc agc 1537 Lys Gly Ala Glu Gly Leu Leu Pro Phe Leu His Pro Arg Pro Ile Ser 500 505 510 ccc tcc agc ccc tcc tac cgg ccc ccg aac acc cgc cgc tcc cgc ctc 1585 Pro Ser Ser Pro Ser Tyr Arg Pro Pro Asn Thrr Arg Arg Ser Arg Leu 515 520 525 tcc ctg ggt ccc tct gct gac cgg gag ctg ctg acc ttc ttg gag agc 1633 Ser Leu Gly Pro Ser Ala Asp Arg Glu Leu Leu Thr Phe Leu Glu Ser 530 535 540 tcc acc ggc agc cct gag gag ccc aat aag ttc cac agc ctg ccc cgg 1681 Thr Gly Ser Pro Glu Glu Glu Pro Asn Lys Phe His Ser Leu Pro Arg 545 550 555 560 agc agc ccc cgg cag gcc cgg ccc acg ata gcc tgc ctg gag cct gca 1729 Ser Ser Pro Arg Gln Ala Arg Pro Thr Ile Ala Cys Leu Glu Pro Ala 565 570 575 gaa gtg agg cac cag gac tcc agc ttt gca cac aaa cct cag gcc tcg 1777 Glu Val Arg His Gln Asp Ser Ser Phe Ala His Lys Pro Gln Ala Ser 580 585 590 590 ggg ggc cag gag gag gcc ccc aacca ccc tca gca cag gcg cac cag 1825 Gly Gly Gln Glu Glu Ala Pro Asn Pro Pro Ser Ala Gln Ala His Gln 595 600 605 ctt gca gcc gcc cag cct gag aac cat gcc tct gcc ttc ccc aga gct 1873 Leu Ala Ala Ala Gln Pro Glu Asn His Ala Ser Ala Phe Pro Arg Ala 610 615 620 cgg tgc cag ggc gtc agt gtc ctc cga aag agg tac agt gag ccg gtg 1921 Arg Cys Gln Gly Val Ser Val Leu Arg Lys Arg Tyr Ser Glu Pro Val 630 630 635 agc ctg ggc tca gca cag tcc cct cct ctc tcg cca ttg gct ctg gga 1969 Ser Leu Gly Ser Ala Gln Ser Pro Pro Leu Ser Pro Leu Ala Leu Gly 645 650 655 att aag gag cat gag ctg gtg aca ggg ctg gcc cag tc aac ctc cag 2017 Ile Lys Glu His Glu Leu Val Thr Gly Leu Ala Gln Phe Asn Leu Gln 660 665 670 ggt tcc cag ggc atg gag gag acc tcc cag ctg act ctg agt gac ttc 2065 Gly Ser Gln Gly Met Glu Glu Thr Ser Gln Leu Thr Leu Ser Asp Phe 675 680 685 agc ccg atg gag cta gag tct gtg ggg cat agg ggc ccg cag tcc ctc 2113 Ser Pro Met Glu Leu Glu Ser Val Gly His Arg Gly Pro Gln Ser Leu 690 695 700 agt gcc agc agc agc agc ctg aca ccc atg ggc aga gat gcc ctg ggg 2161 Ser Ala Ser Ser Ser Ser Leu Thr Pro Met Gly Arg Asp Ala Leu Gly 705 710 710 720 agt ctc agc cca gcg ctg gag gat ggc aag gct gcc ccc gat gag Ser Leu Ser Pro Ala Leu Glu Asp Gly Lys Ala Ala Pro Asp Glu Pro 725 730 735 gga agt gca gct ttg gga tct gtg ggt agc agc gac cct gag aac aaa 2257 Gly Ser Ala Ala Leu Gly Ser Val Gly Ser Ser Asp Pro Glu Asn Lys 740 745 750 gat cct aga cct ctg ttc tgc atc tcg gac acc acc gac tgc tca ctg 2305 Asp Pro Arg Pro Leu Phe Cys Ile Ser Asp Thr Thr Asp Cys Ser Leu 755 760 765 acc ctg gac tgc tca gag gga ac c gac tcc aga ccc aga ggc ggg gac 2353 Thr Leu Asp Cys Ser Glu Gly Thr Asp Ser Arg Pro Arg Gly Gly Asp 770 775 780 ccg gag gaa ggc ggg gaa ggg gat ggc tcc atg tcc tct ggg gtt gga 2401 Pro Glu Glu Gly Glu Gly Asp Gly Ser Met Ser Ser Gly Val Gly 785 790 795 800 gaa atg ggg gac agc caa gtc tcc tcc aac cct aca tcc agc ccc cct 2449 Glu Met Gly Asp Ser Gln Val Ser Ser Asn Pro Thr Ser Ser Pro Pro 805 810 815 ggg gag gct cct gcc ccc gtc tct gtg gat agt gag ccc agc tgc aag 2497 Gly Glu Ala Pro Ala Pro Val Ser Val Asp Ser Glu Pro Ser Cys Lys 820 825 830 ggc ggc ctg ccc agg gac aaa ccc acc aaa agg gat gtt gta gca 2545 Gly Gly Leu Pro Arg Asp Lys Pro Thr Lys Arg Lys Asp Val Val Ala 835 840 845 cca aag aga ggc tcc ctg aaa gag gcg tct ccc ggg gcc tcc aag ccc 2593 Pro Lys Arg Gly Ser Leu Lys Glu Ala Ser Pro Gly Ala Ser Lys Pro 850 855 860 ggg agc gcc cgg cgg agc cag ggg gca gtg gcc aag tct gtg cgg acc 2641 Gly Ser Ala Arg Arg Ser Gln Gly Ala Val Ala Lys Ser Val Arg Thr 865 870 875 875 880 ctg acc gcc tca gag aac gag agc atg cgc aag gtc atg ccc atc acc 2689 Leu Thr Ala Ser Glu Asn Glu Ser Met Arg Lys Val Met Pro Ile Thr 885 890 895 aag tcc agc aga ggc gcc ggc tgg agg cga cca gag cgg tca tcc 2737 Lys Ser Ser Arg Gly Ala Gly Trp Arg Arg Pro Glu Leu Ser Ser Arg 900 905 910 ggg ccc tcc cag aat ccc ccc agc agc aca gat act gtg tgg tca cgc 2785 Gly Pro Ser Gln Asn Pro Pro Ser Ser Thr Asp Thr Val Trp Ser Arg 915 920 925 cag aac tcc gtg cgg agg gcc tcc aca ggc gcc gaa gag cag agg ctg 2833 Gln Asn Ser Val Arg Arg Ala Ser Thr Gly Ala Glu Glu Gln Arg Leu 930 935 940 cc ccg cgg ggg agc agcgg agc acc cgt ccg ggg agg gac gtt 2881 Pro Arg Gly Ser Ser Gly Ser Ser Ser Thr Arg Pro Gly Arg Asp Val 945 950 955 960 ccc ctg cag ccc agg ggt tct ttc aag aag ccc agt gcc aaa cca ctc 2929 Pro Leu Gln Pro Arg Gly Ser Phe Lys Lys Pro Ser Ala Lys Pro Leu 965 970 975 agg aac ctc ccc aga cag aag cct gag gaa aat aag acc tgc cgc gcc 2977 Arg Asn Leu Pro Arg Gln Lys Pro Glu Glu Asn Lys Thr Cys Arg Ala 980 985 990 cac tcc gag ggc cct gag agt ccc aaa gaa gag ccc aag acc ccg tca 3025 His Ser Glu Gly Pro Glu Ser Pro Lys Glu Glu Pro Lys Thr Pro Ser 995 1000 1005 gtg ccc agc gtc ccc cac gaa cta ccc cgt gtc ccg agc ttt gcc cgg 3073 Val Pro Ser Val Pro His Glu Leu Pro Arg Val Pro Ser Phe Ala Arg 1010 1015 1020 aac aca gtg gcc tcc tcc tct cga agc atg aga aca gat ctt cct ccc 3121 Asn Thr Val Ala Ser Ser Ser Arg Ser Met Arg Thr Asp Leu Pro Pro 1025 1030 1035 1040 gtg gcc aaa gcc ccc ggc atc act cgg aca gtg tcg cag cgg cag ctg 3169 Val Ala Lys Ala Pro Gly Ile Thr Arg Thr Val Ser Gln Arg Gln Leu 1045 1050 1055 agg gtg aaa ggg gac ccc gag gat gcc gct ccc aag gac agc agc act 3217 Arg Val Lys Gly Asp Pro Glu Asp Ala Ala Pro Lys Asp Ser Ser Thr 1060 1065 1070 ttg agg cga gcc agc agt gcc cgg gcc ccc aag aag cgc cca gct 3265 Leu Arg Arg Ala Ser Ser Ala Arg Ala Pro Lys Lys Arg Pro Glu Ser 1075 1080 1085 gcg gag ggt ccc agt gcc aac acg gag gcc cct ctg aag gcc aga ggg 3313 Ala Glu Gly Pro Ser Ala As n Thr Glu Ala Pro Leu Lys Ala Arg Gly 1090 1095 1100 gct ggg gaa agg gcc tcc ctc cgt cgg aag gac tcc agt cgg acc acg 3361 Ala Gly Glu Glu Arg Ala Ser Leu Arg Arg Lys Asp Ser Ser Arg Thr Thr 1105 1110 1115 1120 ctg ggg aga atc ctc aat ccc tta cgg aag tgatgggtgc ctgtcctctc 3411 Leu Gly Arg Ile Leu Asn Pro Leu Arg Lys 1125 1130 ctgcctcctg ggattcagac ggtgaagact gacttctggg acgaggatgg ggaaagaggc 3471 agcatgtctt tgttacagat aaagcagcca ctggtgccac tgctagtgac gctgttggga 3531 tggcacagtc caggaggcct gtggactgca gcctgctgtg ctgagccctg ctgcagtcca 3591 gcgtccagat ggatgcacgt tcactactgt gacggccgca cctcccccat gcaccccacc 3651 ctcccccaaa gcccggatcc cgagaaagat ttagtaggag tgtaaggtga cattcttatg 3711 aaacaagtca aaaaagtttt tttcaggcca gtttttatat atcaaagact ttctttttaa 3771 tataaaaatt agctaggtgc agtggttcat gcctgtaatc cagcactttg ggaggctaag 3831 atgagtggat tgcttgagcc taggagttcg agaccagcct aggcaacatg gagaaacccc 3891 gtctctatca gaaatacaaa atttggccga gtgtggtggc acatgcctgt ggccccagcc 3951 actctgaacg ctgagatggg aaggtcactt gagc ccagga ccccaccact gcactccagc 4011 ctggatgaca gagtgagacc ttgtctcaaa caaaacaaaa caaaaatgaa atgttctagt 4071 tttggttcct tttgcagagt gaaatgcctc ccaggaaaaa aatacatacg tatttttttg 4131 cgacagggtc gtgctcttgt ctcccagact ggactgcagt ggcacaatca tagctcactg 4191 cagctttgac ctcccagacc caagtgatcc tcccacctca gcctccctca gagctgggac 4251 tacaggcgtg caccaccacg cctggttaat tgtttttttt taatttatct tttgtagaga 4311 tgggatctca ctatgttgct caggctgatc tcgagctcct gggctcaagt gatcctccca 4371 cctcagcctc ccaaagtgct gggattacag gtgtgagcca ccacacttgg ccagtatatc 4431 ctcagtatga agatattttt atcttcctgt gttctctggc ttcagagttt cacctgccca 4491 cacagggtcc gttgctggca actggacttc cccataagcc ttgggtatcc tgtgatgggc 4551 tgtgtctccc tgaagattgt ctggcttgcc cacttctccg tgcatgactc tgggtgtgag 4611 tctgtctagg aacaggaggg aaagttggac tcagacagaa atcagatgct tccatgtatt 4671 cagggcgcgc attgtgagca gtggagtatg agccttgagg gcctcatggt tgcagggcag 4731 gcttccctgc agatgggtgg cagcccctgg tagaatgctg gatttctctg gaatctagaa 4791 gtgccatatt ttagtggaaa ggcatcaggg ctgtttgaca gtgtgcgtct ttccaatccc 4851 atgttcctcc attcgtgtgt ctgttataaa actgagtgaa ggctgctatg acctgtgttc 4911 actctggtta cagggaggtg caaaccattc tgtctcccag cctttcttct ctctttgtgt 4971 gctcccagca cttccttctt ttctaacatg gcctggagag agtctctctc tccttgtctc 5031 tgtctcttaa taatagtttt taacgtggac atctcttcct tggtacagtg gtttttaaat 5091 cctgagaaga accaagtcag gttttttaaa gcagactaaa agcatgaaat tgctttcaga 5151 agaatgtata tcatcgggaa aagtttgggg gcagagtggg ggaatcaggc tttattcaaa 5211 agaaacagtt gaaaacatgg actttttcta cccaatgccc atttcacgac tcctctgaga 5271 ctaattggga aacggggaaa ttcttggaat ttttttttta agaaactttt ttgtgttttt 5331 tttaatttta ggtcacttat tagtgaaacc tcattttaga tctgacattg gtagatagat 5391 ggatttaggc aaatatgatg cgtttgtggg gaatccacgt ggttgacgtt agaacctccc 5451 ttctgcagac tgttgcctgt catctaagcg aattggaaat gctgagcttc cataagtcag 5511 ctgagtttta aaggtaaacg ttatggctga agtagtaaag cacctgacca caaaacctct 5571 tgtaaaaaca gccctgagta ggtatttcca gggctccaca aagttgctta tgggaatcct 5631 gagctgcttt tcaccatctc aagaagccta agaagttata tatt taatca ggtagacaaa 5691 acagttcaaa gcataaggtc catggtggtg gaaaatggat gcaagtgatt ctaagtttgt 5751 ggatttgtgg atagcagagg gatcgggacc tcttggagga accctgggta ccaagctccc 5811 aggcccttcc tctatcatgg atgctgggtg actttgggaa gtcaccacct cttcccaagc 5871 ctgtttccca tatcacagat gtggggccat ggcctcgatg atggtctcca caggtctttc 5931 cacctctgtg agtccaagtc aggtcaatca gcaaggaccc atctctgccc tgggtcagct 5991 cctcagaacc aacccccagc atctctaaag caaaagcctc acctcaaggg ctgctcagaa 6051 gagagcacct tcagcatgag ttgttgctgg aagatctaat aagctgtgtt tcctgggaag 6111 tggtgcttta cttagccctg tggacaactt ctctatgcat ctgtgtgagc agatgatcat 6171 tgtattacct tttatcggta gtaagcttgg aaaaataatt taagaataca atggagaaat 6231 gtaaataagt atctatgtaa atttgtttaa aataaactga atgtatttaa tggtccattt 6291 atatgttctt ttatgtaaca tgtagtttaa taaagttcct gtttatgaga gtcatgtttc 6351 atctc 6356 <210> 205 <211> 6585 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (4934) <400> 205 cc acc ctg gaa agc aag gac agt gga att ata gcc aca att aca agt 47 Thr Leu Glu Ser Lys Asp Ser Gly Ile Ile Ala Thr Ile Thr Ser 1 5 10 15 tca tcc gaa aat gat gac cgg agt ggc tcc agt ttg gaa tgg aat aaa 95 Ser Ser Glu Asn Asp Asp Arg Ser Gly Ser Ser Leu Glu Trp Asn Lys 20 25 30 gat gga agc cta aga tta ggg gtt cag aag gga gtg ctt cat gac cgc 143 Asp Gly Ser Leu Arg Leu Gly Val Gln Lys Gly Val Leu His Asp Arg 35 40 45 agg gca gat aac tgc tcc cca gtg gca gaa gag gag acc acc ggg tca 191 Arg Ala Asp Asn Cys Ser Pro Val Ala Glu Glu Glu Thr Thr Gly Ser 50 55 60 gca gag agc acg ctg ccc aaa gca gaa tcc tca gct gga gat ggt cca 239 Ala Glu Ser Thr Leu Pro Lys Ala Glu Ser Ser Ala Gly Asp Gly Pro 65 70 75 gtc cct tat tct cag ggc tcc agc tca cta ata atg cca cgg ccc aac 287 Val Pro Tyr Ser Gln Gly Ser Ser Ser Leu Ile Met Pro Arg Pro Asn 80 85 90 95 tca gtt gca gca aca agc tca acc aaa ttg gaa gat ctg agt tat tta 335 Ser Val Ala Ala Thr Ser Ser Thr Lys Leu Glu Asp Leu Ser Tyr Leu 100 105 110 ga c ggg cag aga aat gct cct cta cgg acg tca att aga tta cca tgg 383 Asp Gly Gln Arg Asn Ala Pro Leu Arg Thr Ser Ile Arg Leu Pro Trp 115 120 125 cac aat acg gcc gga ggt agg gca cag gaa gtt aaa gca cga ttt gct 431 His Asn Thr Ala Gly Gly Arg Ala Gln Glu Val Lys Ala Arg Phe Ala 130 135 140 ccc tac aag cca caa gac att ttg ttg ttg aaa ccc ttg ttg ttt gaa gta 479 Pro Tyr Lys Pro Gln Asp Ile Leu Leu Lys Pro Leu Leu Phe Glu Val 145 150 155 cca agc ata aca aca gac tct gtg ttt gtg gga agg gat tgg ctc ttt 527 Pro Ser Ile Thr Asp Ser Val Phe Val Gly Arg Asp Trp Leu Phe 160 165 170 175 cac cag ata gaa gaa aac ttg agg aac aca gaa ctg gca gaa aac aga 575 His Gln Ile Glu Glu Asn Leu Arg Asn Thr Glu Leu Ala Glu Asn Arg 180 185 190 ggc gcg gtg gtg gtt ggc aat gtg gga ttt ggg Aag acg gca atc gat atc Val Val Val Gly Asn Val Gly Phe Gly Lys Thr Ala Ile Ile 195 200 205 tcc aag ttg gtg gcc ctg agc tgc cac gga agc cgc atg ag cag att 671 Ser Lys Leu Val Ala Leu Ser Cys His Gly Ser Arg Met Arg Gln Ile twenty one 0 215 220 gct tcc aac agc ccg ggt tca tca cct aaa acc tct gac ccc act cag 719 Ala Ser Asn Ser Pro Gly Ser Ser Pro Lys Thr Ser Asp Pro Thr Gln 225 230 235 gat ctt cat ttc act ccg ttg ctt tca ccg agt tct tcc aca agt gct 767 Asp Leu His Phe Thr Pro Leu Leu Ser Pro Ser Ser Ser Thr Ser Ala 240 245 250 255 tcc agc aca gct aaa aca cct ctt ggg tct atc agt gct gaa aac cag 815 Ser Ser Thr Ala Lys Thr Pro Leu Gly Ser Ile Ser Ala Glu Asn Gln 260 265 270 aga cca aga gag gat gca gtg aaa tat ctt gct tct aag gtg gtg gcc 863 Arg Pro Arg Glu Asp Ala Val Lys Tyr Leu Ala Ser Lys Val Val Ala 275 280 285 285 tac cac tac tgc cag gct gac aac acg tac act tgc ctg gtg ccc gag 911 Tyr His Tyr Cys Gln Ala Asp Asn Thr Tyr Thr Cys Leu Val Pro Glu 290 295 300 ttt gtg cac agc atc gca gct ttg ctc tgc cgg tcc cat cag 959 Phe Val His Ser Ile Ala Ala Leu Leu Cys Arg Ser His Gln Leu Ala 305 310 315 gcc tac aga gac ctt ctg ata aag gag ccc caa cta cag agc atg ctg 1007 Ala Tyr Arg Asp Leu Leu Ile Lys Glu Pro Gln Leu GlnSer Met Leu 320 325 330 335 agc ctc cga tcc tgt gtg cag gac ccg gtg gca gct ttc aag agg gga 1055 Ser Leu Arg Ser Cys Val Gln Asp Pro Val Ala Ala Phe Lys Arg Gly 340 345 350 gtg ctg gag cca ctca ctg aga aat gag cag aaa att cct gaa 1103 Val Leu Glu Pro Leu Thr Asn Leu Arg Asn Glu Gln Lys Ile Pro Glu 355 360 365 gaa gaa tac att att ttg ata gat ggc tta aat gaa gct gag ttt cat 1151 Glu Glu Tyr Ile Leu Ile Asp Gly Leu Asn Glu Ala Glu Phe His 370 375 380 aaa cct gat tat gga gat acg ctt tct tca ttt att acc aaa att att 1199 Lys Pro Asp Tyr Gly Asp Thr Leu Ser Ser Phe Ile Thr Lys Ile Ile 385 390 395 tct aaa ttt cct gcc tgg ttg aag ttg att gtg act gta aga gca aat 1247 Ser Lys Phe Pro Ala Trp Leu Lys Leu Ile Val Thr Val Arg Ala Asn 400 405 410 415 ttt cag gaa atc ata agt gcg ctg cca ttt gtc ctt tcc tta gat 1295 Phe Gln Glu Ile Ile Ser Ala Leu Pro Phe Val Lys Leu Ser Leu Asp 420 425 430 gac ttc cca gac aac aaa gac atc cac agt gac ctg cac gcc tac gtc 1343 Asp Phe Pro Asp Asn Lys Asp Ile His Ser Asp Leu His Ala Tyr Val 435 440 445 cag cac agg gtg cac agc agc cag gac atc ctc agc aac atc tcc ctg 1391 Gln His Arg Val His Ser Ser Gln Asp Ile Leu Ser Asn Ile Ser Leu 450 455 460 aac ggc aag gcc gat gcc aca ctc att gga aaa gtg agc agc cac ctg 1439 Asn Gly Lys Ala Asp Ala Thr Leu Ile Gly Lys Val Ser Ser His Leu 465 470 475 gtg ctg cgg agc ctc ggc tcc tac ctg tac ccg agc 1487 Val Leu Arg Ser Leu Gly Ser Tyr Leu Tyr Leu Lys Leu Thr Leu Asp 480 485 490 495 ctt ttc cag agg ggc cac ttg gtc att aag agt gcc agc tac aag gtg 1535 Leu Phe Gln Arg Gly His Leu Val Ile Lys A Ser Tyr Lys Val 500 505 510 gtg ccc gtg tct ctc tct gag ctc tat ttg ctt cag tgc aac atg aag 1583 Val Pro Val Ser Leu Ser Glu Leu Tyr Leu Leu Gln Cys Asn Met Lys 515 520 525 ttc atg acc cag tcc gcc t gag agg gca ctt ccg att ctc aac gtg 1631 Phe Met Thr Gln Ser Ala Phe Glu Arg Ala Leu Pro Ile Leu Asn Val 530 535 540 gcc ctc gca tcc ctc cac ccc atg aca gac gag cag atc ttt cag gct 1679 Ala Leu la Ser Leu His Pro Met Thr Asp Glu Gln Ile Phe Gln Ala 545 550 555 att aat gct ggc cac atc cag ggg gag cag gga tgg gaa gac ttt cag 1727 Ile Asn Ala Gly His Ile Gln Gly Glu Gln Gly Trp Glu Asp Phe Gln 560 565 570 575 cag agg atg gac gcc ctc tcc tgc ttc ctc att aag agg cga gac aaa 1775 Gln Arg Met Asp Ala Leu Ser Cys Phe Leu Ile Lys Arg Arg Asp Lys 580 585 590 acc cgc atg ttc tgcc cac gag tgg ctt gta tgg aga 1823 Thr Arg Met Phe Cys His Pro Ser Phe Arg Glu Trp Leu Val Trp Arg 595 600 605 gca gac ggg gaa aac acg gcc ttc ctg tgt gag ccc agg aac ggg cac 1871 Ala Asp Gly Glu Asn Thr Ala Phe Leu Cys Glu Pro Arg Asn Gly His 610 615 620 gcg ctc ttg gca ttc atg ttc tcg cgt cag gag ggc aag ttg aac cgc 1919 Ala Leu Leu Ala Phe Met Phe Ser Arg Gln Glu Gly Lys Leu Asn cag 625 cag acc atg gag ctt ggc cac cac atc ctg aag gcg cac att ttc 1967 Gln Gln Thr Met Glu Leu Gly His His Ile Leu Lys Ala His Ile Phe 640 645 650 655 aag ggc ctc agt aag aag acg gga att tct tca agc c caa gcc 2015 Lys Gly Leu Ser Lys Lys Thr Gly Ile Ser Ser Ser His Leu Gln Ala 660 665 670 ctg tgg atc ggc tac agc acc gag ggg ctg tcc gcc gcc ctg gcc tct 2063 Leu Trp Ile Gly Tyr Ser Thr Glu Gly Leu Ser Ala Ala Leu Ala Ser 675 680 685 ctc agg aat ctc tat act ccc aac gtg aag gtg agc cgt ctc ctg att 2111 Leu Arg Asn Leu Tyr Thr Pro Asn Val Lys Val Ser Arg Leu Leu Ile 690 695 700 ttg gga ggg gcc gtg aac tac agg aca gaa gtg tta aat aat gcc 2159 Leu Gly Gly Ala Asn Val Asn Tyr Arg Thr Glu Val Leu Asn Asn Ala 705 710 715 cca atc ctg tgc gtc cag tct cac ctt ggc cac gag gaa gtt Igt Leu Cys Val Gln Ser His Leu Gly His Glu Glu Val Val Thr 720 725 730 735 ctg ctc ctg gaa ttt ggt gcc tgc ctg gac gga acg tca gag aac ggc 2255 Leu Leu Leu Glu Phe Gly Ala Cys Leu Asp Gly Thr Ser Glun Gly 740 745 750 atg act gcc ctc tgt tac gca gca gct gct ggc cac atg aag ctg gtg 2303 Met Thr Ala Leu Cys Tyr Ala Ala Ala Ala Gly His Met Lys Leu Val 755 760 765 tgt ctg ctg acc aag aag ggagt gtg gac cac ttg gat aag aag 2351 Cys Leu Leu Thr Lys Lys Gly Val Arg Val Asp His Leu Asp Lys Lys 770 775 780 ggc cag tgt gcg ctt gtc cac agt gcc cta cgg ggc cac ggt gac att 2399 Gly Gln Cys Ala His Ser Ala Leu Arg Gly His Gly Asp Ile 785 790 795 ctc cag tac ctg ctg act tgt gag tgg tcg ccg ggt cct ccc cag cca 2447 Leu Gln Tyr Leu Leu Thr Cys Glu Trp Ser Pro Gly Pro Pro Gln Pro 800 805 810 815 815 ggc acc ctg agg aag agc cac gcc ctg cag cag gcg ctg acc gcg gcg 2495 Gly Thr Leu Arg Lys Ser His Ala Leu Gln Gln Ala Leu Thr Ala Ala 820 825 830 gcc agc atg ggc cac agc tcg gtg gtg gtg gtg gtg gtg gtg gtg gtg gc atg gag 2543 Ala Ser Met Gly His Ser Ser Val Val Gln Cys Leu Leu Gly Met Glu 835 840 845 aag gaa cat gaa gta gaa gtc aat ggc acc gac aca ttg tgg gga gaa 2591 Lys Glu His Glu Val Glu Val Asn Gly Thr Asp Thr Leu Trp Gly Glu 850 855 860 aca gcc ctg act gcc gcc gca gga aga ggg aag ctg gag gtc tgt gag 2639 Thr Ala Leu Thr Ala Ala Ala Ala Gly Arg Gly Lys Leu Glu Val Cys Glu 865 870 875 875 ctg ctg ctg ggg cat gga gct gct gtg tcg cgg aca aac agg aga ggg 2687 Leu Leu Leu Gly His Gly Ala Ala Val Ser Arg Thr Asn Arg Arg Gly 880 885 890 895 gtt cca cct ttg ttt tgt gca gca cgc cag ggg cat tgg cag att g735 Val Pro Pro Leu Phe Cys Ala Ala Arg Gln Gly His Trp Gln Ile Val 900 905 910 aga ctg ctg ttg gaa cgc ggc tgt gat gtg aac cta agt gac aag caa 2783 Arg Leu Leu Leu Glu Arg Gly Cys Asp Val Asn Leu Ser Lys Gln 915 920 925 ggc cgg acg ccc ctc atg gtg gct gct tgt gaa ggg cac ttg agc acc 2831 Gly Arg Thr Pro Leu Met Val Ala Ala Cys Glu Gly His Leu Ser Thr 930 935 940 gtg gaa ttc ctc gttca gcc ctt tct tct cta gac aaa 2879 Val Glu Phe Leu Leu Ser Lys Gly Ala Ala Leu Ser Ser Leu Asp Lys 945 950 955 gag ggt ctg tca gca tta agc tgg gct tgt ctg aaa ggt cac agg gca 2927 Glu Gly Leu Ser Ala Le Ser Trp Ala Cys Leu Lys Gly His Arg Ala 960 965 970 975 gtg gtc cag tat ctg gtt gaa gaa gga gct gca ata gac cag aca gac 2975 Val Val Gln Tyr Leu Val Glu Glu Gly Ala Ala Ile Asp Gln Thr Asp 980 985 990 aag aat ggc cgc aca ccc ttg gac ctg gct gcc ttc tat ggc gat gcc 3023 Lys Asn Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe Tyr Gly Asp Ala 995 1000 1005 gag act gtg ctg tac gtg gg gag atc gag cat gtg 3071 Glu Thr Val Leu Tyr Leu Val Glu Lys Gly Ala Val Ile Glu His Val 1010 1015 1020 gac cac agc ggg atg cgg ccc ttg gac aga gcc atc ggc tgc cgg aac 3119 Asp His Ser Gly Met Arg Pro Leu Asp Arg Ala Ile Gly Cys Arg Asn 1025 1030 1035 aca tct gta gtg gtg gcg cta ctc aga aag gga gcc aag tta gga aat 3167 Thr Ser Val Val Val Val Ala Leu Leu Arg Lys Gly Ala Lys Leu Gly Asn 1040 1045 1050 1055 gct gct gcg atg gcc act tcc aaa cct gat atc ttg att ata ctt 3215 Ala Ala Trp Ala Met Ala Thr Ser Lys Pro Asp Ile Leu Ile Ile Leu 1060 1065 1070 tta cag aaa tta atg gag gaa gga aat gtg atg tac aaa aaa ggg aaa Leu Gln Lys Leu Met Glu Glu Gly Asn Val Met Tyr Lys Lys Gly Lys 1075 1080 1085 atg aaa gag gca gcc cag agg tac cag tat gcc tta aga aag ttt cct 3311 Met Lys Glu Ala Ala Gln Arg Ty r Gln Tyr Ala Leu Arg Lys Phe Pro 1090 1095 1100 cga gaa gga ttc gga gag gac atg aga ccc ttc aat gaa tta agg gtt 3359 Arg Glu Gly Phe Gly Glu Asp Met Arg Pro Phe Asn Glu Leu Arg Val 1105 1110 1115 t tat ctc aat ttg tcg cga tgc cga aga aaa acc aat gac ttt 3407 Ser Leu Tyr Leu Asn Leu Ser Arg Cys Arg Arg Lys Thr Asn Asp Phe 1120 1125 1130 1135 ggc atg gca gag gaa ttt gct tcc aag gct ctcag ccc aag 3455 Gly Met Ala Glu Glu Phe Ala Ser Lys Ala Leu Glu Leu Lys Pro Lys 1140 1145 1150 tcc tat gaa gcc ttt tat gcc aga gca aga gcg aag aga aat agc agg 3503 Ser Tyr Glu Ala Phe Tyr Ala Arg Ala Arg Ala Arg Asn Ser Arg 1155 1160 1165 caa ttc gtg gca gct ctg gct gac ctg caa gag gct gtg aaa ctc tgt 3551 Gln Phe Val Ala Ala Leu Ala Asp Leu Gln Glu Ala Val Lys Leu Cys 1170 1175 1180 ccc acc aat cag ag cag agg ctt ctg gcc cgc gta gaa gag gag 3599 Pro Thr Asn Gln Glu Val Lys Arg Leu Leu Ala Arg Val Glu Glu Glu 1185 1190 1195 tgc aaa caa ctc cag agg agt caa cag caa aaa cag cag ggc cc g cta 3647 Cys Lys Gln Leu Gln Arg Ser Gln Gln Gln Lys Gln Gln Gly Pro Leu 1200 1205 1210 1215 cca gct cca ctc aac gac tcc gag aac gaa gag gac acc cca acc cct 3695 Pro Ala Pro Leu Asn Asp Ser Glu Asn Glu Glu Asp Thr Pro Thr Pro 1220 1225 1230 ggc tta agt gac cac ttt cac tct gag gag act gaa gag gaa gaa act 3743 Gly Leu Ser Asp His Phe His Ser Glu Glu Thr Glu Glu Glu Glu Thr 1235 1240 1245 tct ccc cag gaa gaa tct gtt tcc cca act ccc agg tcc cag cca tcc 3791 Ser Pro Gln Glu Glu Ser Val Ser Pro Thr Pro Arg Ser Gln Pro Ser 1250 1255 1260 tca tct gtc cct tcc tca tac atc cga aac ctt caa gaa ggg tta cag 3839 Ser Ser Val Pro Ser Ser Tyr Ile Arg Asn Leu Gln Glu Gly Leu Gln 1265 1270 1275 tcc aaa gga agg ccg gta tcg cca cag agc agg gca gga atc ggc aag 3887 Ser Lys Gly Arg Pro Val Ser Pro Gln Ser Arg Ala Gly Ile Gly Lys 1280 1285 1290 1295 tcc ctg aga gag cct gtg gcc cag cca ggg ctg ctc ctg cag ccc tcc 3935 Ser Leu Arg Glu Pro Val Ala Gln Pro Gly Leu Leu Leu Gln Pro Ser 1300 1305 1310 aag cag gcc cag atc gtg aaa acc agc cag cac ctg ggc tct ggc cag 3983 Lys Gln Ala Gln Ile Val Lys Thr Ser Gln His Leu Gly Ser Gly Gln 1315 1320 1325 tcg gca gtg aga aat ggc agt atg aaa gtt cag atc tct tct cag Ser Ala Val Arg Asn Gly Ser Met Lys Val Gln Ile Ser Ser Gln Asn 1330 1335 1340 cct cct cca agt ccc atg cca ggg aga atc gct gct gct cct gct ggg 4079 Pro Pro Pro Ser Pro Met Pro Gly Arg Ile Ala Ala Ala Ala Pro Ala Gly 1345 1350 1355 agc aga acc cag cat tta gag gga acg ggt act ttc act aca aga gct 4127 Ser Arg Thr Gln His Leu Glu Gly Thr Gly Thr Phe Thr Thr Arg Ala 1360 1365 1370 1375 ggt tgt ggc cac ttt ggg gat cgg ctg ggc ccc agc cag aat gtc cgc 4175 Gly Cys Gly His Phe Gly Asp Arg Leu Gly Pro Ser Gln Asn Val Arg 1380 1385 1390 ctg cag tgt ggt gag aat ggc cct gca cac cct tta cca agt aag acg 4223 Glu Gln Asn Gly Pro Ala His Pro Leu Pro Ser Lys Thr 1395 1400 1405 aaa acc aca gag agg ctt ctg tct cat tcc tcc gtg gct gtg gac gca 4271 Lys Thr Thr Glu Arg Leu Leu Ser His Ser Ser Val A la Val Asp Ala 1410 1415 1420 gcc cct cca aac caa ggt ggg ctg gcg acc tgc agc gac gtg cga cac 4319 Ala Pro Pro Asn Gln Gly Gly Gly Leu Ala Thr Cys Ser Asp Val Arg His 1425 1430 1435 cca gct tcc ctc acc agc tca ggc tct tct ggt tct cca tcc agc agc 4367 Pro Ala Ser Leu Thr Ser Ser Gly Ser Ser Gly Ser Pro Ser Ser Ser 1440 1445 1450 1455 ata aag atg tca agt tca acc agt agt ttg act tcg agc agc agt ttt 4415 Ile Lys Met Ser Ser Ser Thr Ser Ser Leu Thr Ser Ser Ser Ser Phe 1460 1465 1470 tca gat ggc ttc aag gtc caa gga cca gat act aga att aaa gac aag 4463 Ser Asp Gly Phe Lys Val Gln Gly Pro Asp Thr Arg Ile Lys Asp Lys 1475 1480 1485 gtt gta acc cac gtt cag agc ggt aca gct gag cac aga ccc cgc aac 4511 Val Val Thr His Val Gln Ser Gly Thr Ala Glu His Arg Pro Arg Asn 1490 1495 1500 acg ccg ttc atg ggc atc atg gat aag act gcg agg ttc caa cag cag 4559 Thr Pro Phe Met Gly Ile Met Asp Lys Thr Ala Arg Phe Gln Gln Gln 1505 1510 1515 agc aat cct cca agc cgc agc tgg cac tgt ccg gca cca gag ggg ctg 4607 Ser Asn Pro Pro Ser Arg Ser Trp His Cys Pro Ala Pro Glu Gly Leu 1520 1525 1530 1535 ctg aca aac acg tct tct gca gct ggc ctg cag tct gct aac act gag 4655 Leu Thr Asn Thr Ser Ser Ala Ala Gly Leu Gln Ser Ala Asn Thr Glu 1540 1545 1550 aag ccc tct ctc atg caa gtg gga gga tat aat aac caa gcc aaa acc 4703 Lys Pro Ser Leu Met Gln Val Gly Gly Tyr Asn Asn Gln Ala Lys Thr 1555 1560 1565 tgt tct gtt tct acc ctg agt gca agt gt cac aat ggg gca caa gtg 4751 Cys Ser Val Ser Thr Leu Ser Ala Ser Val His Asn Gly Ala Gln Val 1570 1575 1580 aag gag cta gaa gaa agc aag tgc caa att cca gtc cac tct caa gag 4799 Lys Glu Leu Glu Glu Ser Lys Cys Gln Ile Pro Val His Ser Gln Glu 1585 1590 1595 aac agg ata act aag act gtt tct cat ctg tac cag gaa agt atc tcc 4847 Asn Arg Ile Thr Lys Thr Val Ser His Leu Tyr Gln Glu Ser Ile Ser 1600 1605 1610 1615 aaa cag cag cct cat att agt aat gaa gcc cac agg agc cac ctc act 4895 Lys Gln Gln Pro His Ile Ser Asn Glu Ala His Arg Ser His Leu Thr 1620 1625 1630 gca gcc aaa cca aag cga tca t tt ata gag tca aat gtg tgaaccttaa 4944 Ala Ala Lys Pro Lys Arg Ser Phe Ile Glu Ser Asn Val 1635 1640 gaaagcccca tttgtggaat ttggaaacgt gtgttgactc ctggtggtaa attaaatagt 5004 ttttttcatc agaaaaatta ttttttagcc attttttttc tttggggtgg atctgatgcc 5064 attgatatat ctaaaatgtg ggataaaact tctttaatag ctagaaatca ccataaataa 5124 gaatgctaaa cagaattgaa aattatatca acttaaaatt ttaagacagc ccagaagaca 5184 ttaatgactc tcacttatga aattgtttgg cttttgccac tttcctcctt gcctttgcta 5244 tatggtagaa tcacagaact tacttagaga ataaatatgt ctattgttca agagtaacag 5304 gtttaactca tgaccaagtg atgtacatcc aagtgatgta ttctggaaac gatggaattt 5364 tacagttaca gttccattga gtcaaatccc attttatata tacataaaaa ttaagttctg 5424 agtgagttct agctaaatat aagtgcgact gtaaacgcag ccaatttttt taagcagaat 5484 atgagaacac ctaagtattc tcttcatagc agttcctata aagggattaa acacttattt 5544 ctgtgttatg gttcttattc atatattttt atagcacctt tttttggaac ctatatttgt 5604 gcttgaaggt gtttttgata tttggaaaca gtataagcca tttggagtca tgattggtgg 5664 tcaagtggat tcaagctaaa atactaagac cagcattctt agt ggcgctt ataaattagc 5724 tctcacctgg tttccaaact gcttttaaca atggtagtgc tcctggaaca atccttccaa 5784 gctcctctaa ggacaatatt taattcagat actaaaggta agactggttg ttacttttgt 5844 tttgttgtac aattagtact ttatagtcac atgttgtata tattaaatag cccagtttta 5904 ttcagacttg taaatagaac tatttcaatg tagttaatct aaaaacaaaa aagaaacccc 5964 agtcacgatt tgcatgttct ctgtaagctt catccatgct ggttattgca ctgaatgata 6024 tattattagg gcatgttaac agtataccag taacagcact ttatctcatt tatatgaaca 6084 cctttgaggt gctacttaag tccaagctct gatgtattat tcatttgtaa agataaggta 6144 caggaatgaa ccttggttta aaggtatttt tatatgaaaa tggtgtgtta ttggaagatg 6204 ttaaagtgct aatttgagag aagtaggagt gtatctgttt tatatgttgg gatgtgaaat 6264 ttattttcta aaattgagga gaaggaagtt atatatttgc agaatgtttt aaagtgaatt 6324 gttgtaatga agttcctgtg aacatcatta tggttttgta caaataggaa cctctgatgt 6384 cattcttcaa cgtttgttcc tgtgtgtaca attgtacttt gtatgaacag ctttatcatt 6444 tttataggct ttccatgagt tttgctgtaa ctactatggc ttatttattt tctttaatat 6504 ttgtgaaagt cttactcctt tgttagtttt gtttctgcac aactactg ta cttttccata 6564 tggaataaag actattaata g 6585 <210> 206 <211> 6782 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (105) .. (1706) <400> 206 cagggggagc accgagcacc acggtgtcgt gcgcttcgag gcgcggcgtg ggaagaaggc 60 tggttcattc tgccacccct ctgcattaag acacaaggtg ctga ccg cag aga cct 116 Pro Gln Arg Pro 1 gcc atg aaa gag cag cag ga c gac atca gac gac atca gac gac atca gac gac gac atca gac gac atca gac gac atca gac gac atca gac gac atca gac gac gac atca gac gac atca gac gac atca gac gac atca gac gac atca gac gac atca gac gac atca gac gac atca gac gag at g Gln Trp Arg Gln Arg Met Leu Phe Gly 5 10 15 20 ata ttc gct tgg ggg ctc ctc ttt ttg ctg att ttc atc tac ttc acc 212 Ile Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr 25 30 gac agc aac ccc gct gag cct gta ccc agc tcc ctc tcc ttc ctg gag 260 Asp Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu 40 45 50 acc agg agg ctc ctg ccg gtg cag ggg aag cag cgg gcc atc atg ggc 308 Thr Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly 55 60 65 gcc gca cat gag ccc tcc ccg cct ggg ggc ctg gac gca cgc cag gcg 356 Ala Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala 70 75 80 ctg ccc cgc gcc cac cca gcc ggt tcc ttt cat gcg ggg cct gga gac 404 Leu Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gl y Asp 85 90 95 100 ctg cag aaa tgg gcc cag tcc caa gat ggg ttt gaa cat aaa gag ttt 452 Leu Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe 105 110 115 ttt tca tcc cag gtg ggg aga aaa tct caa agt gct ttc tac ccg gag 500 Phe Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu 120 125 130 gat gac gac tac ttt ttt gct gct ggt cag cca ggg tgg cac agc cac 548 Asp Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His 135 140 145 act cag ggg aca ttg gga ttc cct tcc ccc ggg gag cca ggc cca cgg 596 Thr Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg 150 155 160 gag ggg gct ttt ccg gct gca cag gtc cag agg agg cgg gtg aag aag 644 Glu Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys 165 170 175 180 agg cac cgg agg cag aga agg agc cac ggg ttg ggc gac gac 692 Arg His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp 185 190 195 ggc gac agg ctg tac tcc tcc atg tcc agg gcc ttc ctg tac cgg ctc 740 Gly Asp Arg Leu Tyr Ser Ser Met Serg Ala P he Leu Tyr Arg Leu 200 205 210 tgg aag ggg aac gtc tct tcc aaa atg ctg aac ccg cgc ctg cag aag 788 Trp Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys 215 220 225 gcg atg aag gat tacg acc gcc aac aag cac ggg gtg cgc ttc cgc 836 Ala Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg 230 235 240 ggg aag cgg gag gcc ggg ctg agc agg gca cag ctg ctg tgc cag ctg 8 Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu 245 250 255 260 cgg agc cgc gcg cgc gtg cgg acg ctg gac ggc acc gag gcg ccc ttt 932 Arg Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe 265 270 275 tct gcg ctg ggc tgg cgg cgc ctg gtg ccc gcc gtg ccc ctg agc cag 980 Ser Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln 280 285 290 ctg cac ccc cgc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gc gtc gtc atg tct gca ggc 1028 Leu His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly 295 300 305 gca atc ctc aac tct tcc ttg ggc gag gaa ata gat tct cat gat gcg 1076 Ala Ile Leu Asn Ser Ser Leu Gl y Glu Glu Ile Asp Ser His Asp Ala 310 315 320 gtt ttg aga ttt aac tct gct cct aca cgt ggt tat gag aaa gat gtt 1124 Val Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val 325 330 335 340 ggg aat aaa acc acc ata cgc atc att aat tcg cag att ctg acc aac 1172 Gly Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn 345 350 355 ccc agc cat cac ttc att gac agt tca ctg tat aaa gac gtc att ttg 1220 Pro Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu 360 365 370 gtg gcc tgg gac cct gcc cca tat tcc gca aat ctt aac ctg tgg tac 1268 Val Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr 375 380 385 aaa aaa ccg gat tac aac ctg ttc act cca tat att cag cat cgt cag 1316 Lys Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln 390 395 400 aga aac cca aat cag cca ttt tac att ctt cat cct aaa ttt ata tgg 1364 Arg Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp 405 410 415 420 cag ctc tgg gat att atc cag gag aac act aaa gag aag att caa cca 1412 Gln Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro 425 430 435 aac cca cca tct tct ggt ttc att gga atc ctc atc atg atg tcc atg 1460 Asn Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met 440 445 450 tgc aga gag gtg cac gtg tat gaa tat atc cca tcc gtg cgg cag acg 1508 Cys Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr 455 460 465 gag ctg tgc cac tac cac gag ctg tac gca gcc tgc acc ctc 1556 Glu Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu 470 475 480 ggg gcg tac cac cca cta ctc tat gag aag ctc ctg gtg cag cgc ctg 1604 Gly Ala Tyr His Pro Glu Lys Leu Leu Val Gln Arg Leu 485 490 495 500 aac atg ggc acg cag ggg gat ttg cat cgc aag ggc aag gtg gtt ctt 1652 Asn Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu 505 510 c 515 cct ttc cag gcg gtg cac tgc cct gca cca agt cca gtc att cca 1700 Pro Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro 520 525 530 530 cac tct taaaaagggt ttcttgggaa tcaatgtgca ataaggtact actg ttgtac 1756 His Ser tcaaagtcac aaaagaatac ttgaagatag attttagaca gtgtagtttt gagtctttaa 1816 acagtaattt agtggtggtc atgataatcc ttctctttct aagccattga gtatgtatta 1876 ctgctttgaa catagaaatg gtttttttaa aaaaataagg ctcaagaaag atgcaaaacc 1936 aaggatagct agaaagaaaa cacatgtatg accatgggta tgatacctcc agaaatgtta 1996 acaacttatt cttctgccat gagtacccct catcagggtt ggtttcaatg acaggttttg 2056 gtgatgttcc tgaccatatg aagtggttta tgtttagaaa cattcaaatt gagggacatc 2116 atttacagca tcgagtgtgt cagttataca tgcattcatc attaaatatc ctaggtttta 2176 tgacagacat tgaaattatc actcagatgt gtttaacagc aaaaaattcc cagcacatcc 2236 tggcaaaggc ttttatttcc aaccgttgca ttcttcatct ctgcctccca ttgcccactg 2296 aatgctttgc tttctgtgca tcaagacaga gttctaaaac cagaaaacat ccatcttgaa 2356 aggtccaaga aaaagccaaa ttccatatag caccacagag gaggcccttt gtttccctgc 2416 agtatttcaa ccaggaacat tagtatcaca tccaccagga ggcacatcac tggcaagtaa 2476 catagaatca cagggctgca ggtgcccctg gacactcccc ggttctggct tttctgcctt 2536 gtacctcctc acctgcagat ctaccctgca gcttttgcat agtcagtgac ac acttgaca 2596 attggcacag ctgtgctggg gaagacggga gacaccttgc tccttccaaa ctagaaggaa 2656 agattttgga gccatcaccc tgtgcttcta gggatgcacg cctgtcttta ttatacaggt 2716 ttcttgcagg tttttatcag ccagtgggaa ctccacagtg atgagcactg aatcttcact 2776 aaatcttcct acagacattt aggaatccag tccttgcttt tgcagatatg ttttatgtca 2836 gcagcatgac aaagccatat aattaaataa tttatgtgaa agcattgctt attaacaagg 2896 aaaatatgta gatgcttcag agggaaaggc agctagaggg aaattttcat cccaatatgt 2956 tagctatatt cagggttgat tttttcttta atctcaactg tcactgatac attgaaaaat 3016 ttttgctatg aatatagtga aacagaaaca ttctgtaata ccttaattaa acatgctatt 3076 atttcaatgt ataaccaaaa catatctcca tggtacagtt aagacttgtt gcaatgacaa 3136 tagcagctta attaaatgcg ttctcccttg caaaatgtat gaatgtcagg agagtttagt 3196 ggaaaagttt tctttgtttc aggattggtt tcttctagac tgttctcagg actactttct 3256 tgagcaagaa tggcttacag agactgaagg cttctgtttg gttagtctat tcagcagata 3316 tggagctgga aaacaagaca tctcctatag cttgctataa tagtgaagga gaaattggaa 3376 agttttaatc acaataatat ccaataaaag cccattttga gagttttgtt attaagt caa 3436 tgagaaggga taggtaactt tgtcctatat attaacttat gtctaaatag acatggttaa 3496 gccatgttcc tttctaattt cttttctttt cttttttttt tttttttttt tgagacagtc 3556 tctcgctctg tcgcccaggc tagagtgcag tggtgcgatc ttggttcact gccagctctg 3616 cctcccacgt tcacaccatt ctcctgcctc agcctcctga gtagctgggg actacaggca 3676 cctgccacca cgcccagcta attttttgta tttttagtag agacagggtt tcaccgtgtt 3736 agccagggtg gtctcgatct cctgaccttg tgatctgcct gcctcggcct cccaaagtga 3796 tgggattata ggcgtgagcc accaccgcgc ccggtcattc ctttctaatt tcttgaaaaa 3856 actttgtctt gtccttatgt ttacatgtgt gtaataattt cagcaactct ggaatgtggg 3916 tgaggtggct gtggtggatg aatattactc cctaccctcc ttggatcttt ctagatcttc 3976 cagaccatta aatgcccctg aagctccttt tatagttttg caagtggatt tacttgtaga 4036 catccttact atccagcata atcccccttg gctgacatga gaacttggtt agaggagaat 4096 ttattggggt cagtgtaaat attcaagttc aaaagcctca gaacccaaca ctttaaagat 4156 ttttaaatgg aattttgtcg tagtcattgt acttttaaaa tagtactttc agtttcattg 4216 aggttacaag aaagactgaa gagtacaaag gaaatttagt tacaattttt gcatttatta 42 76 tggccttaaa gactcttggg aatcaggctc tgttcaacag tcaataaatg taatacacac 4336 attaatatag tactgactgg gcgttcttct ataaaagttt aagttctttg gcttctaaga 4396 aaatgttggg cagttacagt taacttgatg actacttctg gtattagcca aatgggtcct 4456 aagtggcagc attttgccag acattgacta aatccttaca tgccacattt actgaattcc 4516 aataaacata tagttcttct gtggagtagt taacagtaag tggcagctca ctgaatttct 4576 cccaggttct gtctcttcca aaatcctcca tcctctctta tgaagggaag ctgataaaaa 4636 aaaatcctct tggtgcaagc tgaagctgtt aaggattcct tttttcactc tcaggaccaa 4696 cagacattct tttgtatttc aagataattt cacctgttgt tgttgttgtt gttgttgttg 4756 ttgttgttgt tgttgttaca aagaaacaaa ttttgagcag caatgacaat tcaaccatat 4816 ctagattctc cctaccttat ttctccagcc agtcacacca ggcagacggg taacctttaa 4876 cagacctggt gttctcatgg aataccgatg ctcgtcccag ggagctgacc tttctcacta 4936 tgtccttata gagctgctct tacagagaac tttgtgctca ggaccaaggg atggtcaatt 4996 aaaagttgca tgtaagcatc aggcttggat gggcaaggga gggcttttat acatctttga 5056 acgaccaggt ctttccttgt ctgcctgaag gcagagcttc gagaaacagc acttcccatg 5116 tg tctggtcc tcttggtctc tcagccagac acttaatcaa tcctggactc tccagtagtc 5176 ctcagtcatt gtagccatag catctgcaaa aaaagaaatg ctaaaataat cattagcgtt 5236 ttcaaaatta ggaaatcaaa gtagctgggt cactctctta catgtgtatg agccagttaa 5296 ttctgctgga cagatcatac ttacgctgct gattgactct tctgagcagt aacacatctc 5356 ctgaattaat taggtaggtc ccgtttgggt gctttaagtg ggatcagtct tagatgagtg 5416 ccagtatgtg attgaatttc atacgcacaa atgccatgat tcaagttctc tctccagttt 5476 ttcttataga tcaacacaca gtacatgtgg tcagttactt ggttgaattt ctgcttagct 5536 gtggtaagag acagagaaag ggagtgaggt gggaccaggg gaattatcag aaagacatga 5596 gtgaacctat tggccaggta gcttccaagt atgttctatt gtattgtctg ttttgattct 5656 gatagtttag aactctttct gatagtttag aactcttacc cagtggttac atgactgatc 5716 aaggcaactc catctggaaa ttaattgctt gggtaaaatg tccctgagtt tcaacttgtc 5776 ttttatctct ggatattctc ttatgagatt attatgcatg tttctgtcac atgggcatta 5836 tttacacact tgataaatga aaggtatttc tctgtccgtt caaggaaata aaatgtaagt 5896 tcttgtttta ttaaatgaat gaagcctttt ggttaaaaaa aaagtaatgt aatatgtttc 5956 tgttcaa act tgagctaatg acatttaagg aattaaagac attgatctag ttcttagtat 6016 gaaaagtgta catgtagata tagttatata attgtgtata tacatatcta cacacatggt 6076 tggttttata ttgctttttc atcaatattt ttgactgaaa cctttacaat aaattttatt 6136 ttaattatgt aaccactaat attttgagag aaggaagcaa atgttatatg tccttctgtt 6196 aaaagaaaaa aaattcagtc ctccgccaac cgcttcccac acactcatac tctgcacatc 6256 ttggctacat taaaatggac tgacagaatt atttaaaagg cactatgaag gtagaacact 6316 accttaatat tttatcctag tcagaagcct gatttaacac tgaactttga agggaagctt 6376 agctgtagct catggctttc aaagattaga agaaacattt actggttcta tggaaaatag 6436 tcttcttgct aggtagattg gaaacaaaga aattgcattg gtggtgttaa aatctaacat 6496 ttataacaaa tcctgtttta ttctagatga aatacttaga caattcttcc agtggaaacc 6556 agtgaacttt tttaacagct ttgggaattc ttttgtatga taatttttaa aatgaaatgt 6616 gtactcttca aactaattaa agcttgaagt tttccaggag tcgcatttta aaagtgtttg 6676 tacacatttt aacacttgga tattttctat tttggttttg tatattttta tgtatacaca 6736 atgtacagac ttttttcttg taaataaaac atgttttcat ttgtct 6782 <210> 207 <211> 6473 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1170) .. (6473) <400> 207 ggacactcac cagccctcgc tcaggcacct gctcacacgg ccagaggtca tcacggccct 60 cagcaaggtg agggccgagt gcaacaaggt gaccgccatg tccctgttcc actcgagcct 120 ctccaagtac agccacctgg aggaatttga gcagatccag tcacagacct tctcccaggt 180 gcagatgttc ctcaaggaca gctggatcag ctcgctaaag gtggccatgc gcagcagcct 240 gcgcgacatg agcaagggct ggtacaacct ctacgagacc aactgggagg tgtacctcat 300 gtccaagctg cgcaagctga tggagctggt gaagtacatg ctgcaggaca cactgcgctt 360 cctggtgcag gactcacttg ccagcttctc acagttcatc agcgacacct gttgcagcgt 420 gctcaactgc accgatgaca tggtctgggg tgacgactta attaacagcc cctacaggcc 480 ccggaagaat cccctgttca tcatggacct ggtgctggac agctctgggg tgcactatag 540 caccccactg gagcagtttg aggcatctct gctgaacctc ttcgacaagg gcatcctggc 600 cacccatgcc gtgccccagc tggagaagct ggtgatggag gacatcttca tcagcggtga 660 ccccctgctg gagtccgtgg gccttcatga gccactggtg gaagagctac gggccaccat 720 tgccagtgcc gtgtccaagg ccatgatccc actgcaggcc tacgccaagg agtaccgaaa 780 gtacctggag ctgaacaaca atgacattgc ctcctttctc aaaacctacc agacgcaggg 840 cctgttggcc caggaggtgc gggaggtagt gctcacccac ctgcgggaga aggagatcct 900 ggacagctcg ctgcccagca gcatcatcat tgggcctttc tacatcaaca ccgacaatgt 960 caagcagagc ctgtccaaga aacgcaaggc cctggccact tccgtgctgg acatccttgc 1020 caagaacctg cataaggagg tggatagctc ctcagcaacc cagggagccc accaggagca 1080 cccctcttgg aaagcgccgc aggatgttgt ggtggagggg acagttacct gtcgggagat 1140 gctggagacc aaggaggaag agcaggtga ggg aag gca agg gag cag cat gct 1193 Gly Lys Ala Arg Glu Gln His Ala 1 5 gcc ctc ccc agc gcc tcc tcc cac tgc cag atc tgc gag gag ttc cgc 1241 Ala Leu Pro Ser Ala Ser Ser His Cys Gln Ile Cys Glu Glu Phe Arg 10 15 20 agc atc agc cgc aag atc tat gag aag ccc aac agc att gag gag ctg 1289 Ser Ile Ser Arg Lys Ile Tyr Glu Lys Pro Asn Ser Ile Glu Glu Leu 25 30 35 40 gct gag ctg cga gag tgg atg aag ggc atc ccg gag agg ctg gtg ggc 1337 Ala Glu Leu Glu Trp Met Lys Gly Ile Pro Glu Arg Leu Val Gly 45 50 55 ctg gag gag cgg att gtg aag gtc atg gat gac tac cag gtc atg gat 1385 Leu Glu Glu Glu Arg Ile Val Lys Val Met Asp Asp Tyr Gln Va l Met Asp 60 65 70 gaa ttc ctc tac aac ctc agc tca gat gac ttc aat gac aaa tgg att 1433 Glu Phe Leu Tyr Asn Leu Ser Ser Asp Asp Phe Asn Asp Lys Trp Ile 75 80 85 gcc agc aac tgg cct tct aag at ctt ggg cag ata gag ctg gtg cag 1481 Ala Ser Asn Trp Pro Ser Lys Ile Leu Gly Gln Ile Glu Leu Val Gln 90 95 100 cag cag cat gtg gag gat gag gag aag ttc cgc aaa atc cag atc atg 1529 Gln Gln His Val Glu Asp Glu Glu Lys Phe Arg Lys Ile Gln Ile Met 105 110 115 120 gat cag aac aac ttc caa gag aag ctg gaa ggg ctg cag ctg gta gta 1577 Asp Gln Asn Asn Phe Gln Glu Lys Leu Glu Gly Leu Gln Leu Val 125 130 135 gct ggc ttc tcc atc cat gtg gag att tca cgt gca cac gag atc gcc 1625 Ala Gly Phe Ser Ile His Val Glu Ile Ser Arg Ala His Glu Ile Ala 140 145 150 aac gag gtg cgg cgt gtc aag aag cag ctg aag gac tc cag cag ctg 1673 Asn Glu Val Arg Arg Val Lys Lys Gln Leu Lys Asp Cys Gln Gln Leu 155 160 165 gcc atg ctc tac aac aac cgc gag cgc atc ttc agc ttg ccc atc acc 1721 Ala Met Leu Tyr Asn Asg Arg Ph e Ser Leu Pro Ile Thr 170 175 180 aat tat gac aag ctc tcc agg atg gtg aag gag ttc caa ccc tac ctg 1769 Asn Tyr Asp Lys Leu Ser Arg Met Val Lys Glu Phe Gln Pro Tyr Leu 185 190 195 200 gac ctt tgg acc aca gcg tct gac tgg ctg cgc tgg tcg gag agc tgg 1817 Asp Leu Trp Thr Thr Ala Ser Asp Trp Leu Arg Trp Ser Glu Ser Trp 205 210 215 atg aat gac ccc ctc tct gcc atc gat gct gag cag ctg gag aag aac 1865 Asn Asp Pro Leu Ser Ala Ile Asp Ala Glu Gln Leu Glu Lys Asn 220 225 230 gtg gtt gaa gcc ttc aag acc atg cac aag tgc gtg aag cag ttt aag 1913 Val Val Glu Ala Phe Lys Thr Met His Lys Cys Val Lys Gln Phe Lys 235 240 245 gac atg cca gcc tgc cag gaa gtg gcc ttg gac atc cgg gcc cgc atc 1961 Asp Met Pro Ala Cys Gln Glu Val Ala Leu Asp Ile Arg Ala Arg Ile 250 255 260 gag gag ttc aaa cca tac atc cca ctc cag ggg ctg cgc aac cct 2009 Glu Glu Phe Lys Pro Tyr Ile Pro Leu Ile Gln Gly Leu Arg Asn Pro 265 270 275 280 ggc atg cgg atc cgg cac tgg gag aca ctg tcc aac cag atc aac atc 2057 Gly Met Arg Ile Arg His Trp Glu Thr Leu Ser Asn Gln Ile Asn Ile 285 290 295 aat gtc agg ccc aag gcc aac ctg acc ttt gct cgc tgc ctg gag atg 2105 Asn Val Arg Pro Lys Ala Asn Leu Thr Phe Ala Arg Cys Leu Glu Met 300 305 310 aac ctg cag gac cat atc gag agc atc agc aag gtg gct gag gtg gct 2153 Asn Leu Gln Asp His Ile Glu Ser Ile Ser Lys Val Ala Glu Val Ala 315 320 325 ggc aag gag tac gcc atc gag cag gca ctg gag aag atg aag gag 2201 Gly Lys Glu Tyr Ala Ile Glu Gln Ala Leu Asp Lys Met Glu Lys Glu 330 335 340 tgg tcg acc atc ctg ttc aat gta ctg ccc tac aag gcg aca gac acc 2249 Trp Ser Thr Ile Leu Phe Asn Val Leu Proyr Lys Ala Thr Asp Thr 345 350 355 360 tac atc ctg aag agc ccg gac gag gcc tca cag ctg ctg gac gac cac 2297 Tyr Ile Leu Lys Ser Pro Asp Glu Ala Ser Gln Leu Leu Asp Asp His 365 370 375 atc gtc atg acc cag aat atg tca ttt tca ccc tac aag aag ccc ttt 2345 Ile Val Met Thr Gln Asn Met Ser Phe Ser Pro Tyr Lys Lys Pro Phe 380 385 390 gag cag cgc atc aac tcc tgg gag aac aaa ctg aag ctg acc cag gag 2393 Glu Gln Arg Ile Asn Ser Trp Glu Asn Lys Leu Lys Leu Thr Gln Glu 395 400 405 gtt ctg gag gag tgg ctg aac tgt cag cgg tcc tgg ctc tac ctg gag 2441 Val Leu Glu Glu Trp Leu Asn Cys Gln Arg Ser Trp Leu Leu Glu 410 415 420 ccc atc ttt agc tct gag gac atc aac cag cag ctg cct gtg gag agc 2489 Pro Ile Phe Ser Ser Glu Asp Ile Asn Gln Gln Leu Pro Val Glu Ser 425 430 435 435 440 aag cgc tac cag acc atg gag cgg atc tgg aag aag atc atg aag aat 2537 Lys Arg Tyr Gln Thr Met Glu Arg Ile Trp Lys Lys Ile Met Lys Asn 445 450 455 gcc tac gag aac cgg gag gtg atc aat gtg tgt tcc gac ctg aga atg 2585 Ala Tyr Glu Glu Val Ile Asn Val Cys Ser Asp Leu Arg Met 460 465 470 ctg gac agc ctg cgg gac tgc aac aag att ctg gac ctg gtg cag aag 2633 Leu Asp Ser Leu Arg Asp Cys Asn Lys Ile Leu Asp Leu Val Gln Lys 475 ggc ctc agc gag tat ctg gag acc aag agg agc gcc ttc ccc aga ttc 2681 Gly Leu Ser Glu Tyr Leu Glu Thr Lys Arg Ser Ala Phe Pro Arg Phe 490 495 500 tac ttc ctg tca gat gat gaa cta cta gat atc cg cag aca aag 2729 Tyr Phe Leu Ser Asp Asp Glu Leu Leu Glu Ile Leu Ser Gln Thr Lys 505 510 515 520 gac ccc acg gcc gtg cag cca cac ctg cgc aag tgc ttc gag aac atc 2777 Asp Pro Thr Ala Val Gln Pro His Leu Arg Lys Cys Phe Glu Asn Ile 525 530 535 gct cgg ctg cta ttc cag gag gac ctg gag atc acg cac atg tac tca 2825 Ala Arg Leu Leu Phe Gln Glu Asp Leu Glu Ile Thr His Met Tyr Ser 540 545 gg gcc gag gag gta cag ttg tgc ttc tcc atc tac ccc tcc agc 2873 Ala Glu Gly Glu Glu Val Gln Leu Cys Phe Ser Ile Tyr Pro Ser Ser 555 560 565 aac gtg gag gac tgg ctg cgg gag gtg gag cgc agc agag agag ag921 Asn Val Glu Asp Trp Leu Arg Glu Val Glu Arg Ser Met Lys Ala Ser 570 575 580 gtg cac gac atc att gag aag gcc atc agg gcc tac ccc acg atg ccc 2969 Val His Asp Ile Ile Glu Lys Ala Ile Arg Ala Tyr Pro Thr Met Pro 585 590 595 600 agg acc cag tgg gtt ctg aac tgg cct ggc cag gtg acc atc gct ggg 3017 Arg Thr Gln Trp Val Leu Asn Trp Pro Gly Gln Val Thr Ile Ala Gly 605 610 615 tgc cag acc tac tgg acc at g gag gtg gca gag gct ctg gag gcc ggc 3065 Cys Gln Thr Tyr Trp Thr Met Glu Val Ala Glu Ala Leu Glu Ala Gly 620 625 630 aac ctc aga agc caa ctg ttc ccc cag ctc tgc cag cag Arg ctc ag atg ag ctc agat gat Ser Gln Leu Phe Pro Gln Leu Cys Gln Gln Leu Ser Asp 635 640 645 ctg gtg gcc ctt gtg cgg ggg aag ctg tcc cgc atg cag cgg gca gtg 3161 Leu Val Ala Leu Val Arg Gly Lys Leu Ser Arg Met Gln Arg Ala Val 655 660 ctg tca gcg cta atc gtc att gag gtc cat gcc aag gac gtg gtg agc 3209 Leu Ser Ala Leu Ile Val Ile Glu Val His Ala Lys Asp Val Val Ser 665 670 675 680 680 aag cta atc cag gag aac gtg gtc ag gac ttc cag tgg atc 3257 Lys Leu Ile Gln Glu Asn Val Val Ser Val Asn Asp Phe Gln Trp Ile 685 690 695 tca cag ctg agg tac tac tgg aca aat aat gac ctg tat atc cgt gct 3305 Ser Gln Leu Arg Tyr Tyr Trp Thr Asn Asn Asp Leu Tyr Ile Arg Ala 700 705 710 gtg aat gct gag ttc atc tat ggc tat gag tac ctg ggc aac agt ggg 3353 Val Asn Ala Glu Phe Ile Tyr Gly Tyr Glu Tyr Leu Gly Asn Ser Gly 715 720g agg ggt atc acg ccc ctc acc gac agg tgc tac ctg aca ctg acc 3401 Arg Leu Val Ile Thr Pro Leu Thr Asp Arg Cys Tyr Leu Thr Leu Thr 730 735 740 gga gct ctg cac ctc aag ttt ggg ggt gcc cca gct ggc cca g 3449 Gly Ala Leu His Leu Lys Phe Gly Gly Ala Pro Ala Gly Pro Ala Gly 745 750 755 760 aca ggc aaa act gag acc acc aaa gac ctg ggt aag gcc ttg gcc ata 3497 Thr Gly Lys Thr Glu Thr Thr Lys Asp Leu Gly Lys Ala Leu Ala Ile 765 770 775 cag acc gtt gtg ttc aac tgc tct gac cag ctc gac ttc atg gcc atg 3545 Gln Thr Val Val Phe Asn Cys Ser Asp Gln Leu Asp Phe Met Ala Met 780 785 790 ggc aag ttc ttc ttc ttc ttc ttc ttc ttg cg gcc agt gct ggg gcc tgg gcc tgc ttc 3593 Gly Lys Phe Phe Lys Gly Leu Ala Ser Ala Gly Ala Trp Ala Cys Phe 795 800 805 gac gag ttc aat cgc atc gac atc gag gtg ctg tct gtg gtg Ascg cag Pg 36 Arg Ile Asp Ile Glu Val Leu Ser Val Val Ala Gln 810 815 820 cag atc acc acc atc cag aag gcg cag cag cag cgg gtg gaa cgc ttc 3689 Gln Ile Thr Thr Ile Gln Lys Ala Gln Gln Gln Arg Val Glu Arg Phe 825 830 835 840 atg ttt gag ggt gtg gag atc cca ctg gtg cca tcc tgc gca gtg ttt 3737 Met Phe Glu Gly Val Glu Ile Pro Leu Val Pro Ser Cys Ala Val Phe 845 850 855 atc acc atg aac ccg ggc tac gc ggc tac gct acg gag ctg cct gac aat 3785 Ile Thr Met Asn Pro Gly Tyr Ala Gly Arg Thr Glu Leu Pro Asp Asn 860 865 870 ctg aag gcg ctc ttc cga ccc gtg gcc atg atg gtt cca gat tac gcc 3833 Leu Lys Ala Leu Phe Phe Val Ala Met Met Val Pro Asp Tyr Ala 875 880 885 885 atg atc act gag atc tcc ctc tat tcc ttt ggc ttt aat gag gcc agt 3881 Met Ile Thr Glu Ile Ser Leu Tyr Ser Phe Gly Phe Asn Glu Ala Ser 890 895 900 gtg ctg gct aag aag atc aca acc acc ttc aag ctg tct tct gag cag 3929 Val Leu Ala Lys Lys Ile Thr Thr Thr Phe Lys Leu Ser Ser Glu Gln 905 910 915 915 920 ctc agc tcc cag gat cac tat gac ttc ggg atg aga gcc gtg aaa act 3977 Leu Ser Ser Gln Asp His Tyr Asp Phe Gly Met Arg Ala Val Lys Thr 925 930 935 gtg atc tcg gct gct ggg aac ctc aag cga gaa aac ccc agc atg aat 4025 Val Ile Ser Ala Ala Gly Asn Leu Lys Arg Glu Asn Pro Ser Met Asn 940 945 950 gag gag ctg atc tgc ctc cgg gcc atc cgt gat gtg aac gtg ccc aag 4073 Glu Glu Leu Ile Cys Leu Arg Ala Ile Arg Asp Val Asn Val Pro Lys 955 960 965 ttc gcg ca ctc aag ctc ttc tct ggc atc gtg tcc gac ctg 4121 Phe Leu Gln Glu Asp Leu Lys Leu Phe Ser Gly Ile Val Ser Asp Leu 970 975 980 ttt ccc acc atc aag gag gag gac acg gac tac ggc atc ctg gat gag Thr Ile Lys Glu Glu Asp Thr Asp Tyr Gly Ile Leu Asp Glu 985 990 995 1000 gcc atc cgc gag gcc tgc agg aac agc aac ctc aag gat gtg gag ggc 4217 Ala Ile Arg Glu Ala Cys Arg Asn Ser Asn Leu Lys As Gly 1005 1010 1015 ttc ctg aca aag tgc atc cag ctc tac gag acc acg gtg gta cga cac 4265 Phe Leu Thr Lys Cys Ile Gln Leu Tyr Glu Thr Thr Val Val Arg His 1020 1025 1030 ggc ctc atg ctc gtc gcc ccc aca ggc aag agt act tgt tac 4313 Gly Leu Met Leu Val Gly Pro Thr Gly Ser Gly Lys Ser Thr Cys Tyr 1035 1040 1045 aga gtc ctg gca gct gcc atg acg tca ctg aaa ggg cag cca tcc atc 4361 Arg Val Leu Ala Ala Ala Met Thr Ser Leu Lys Gly Gln Pro Ser Ile 1050 1055 1060 agt ggt ggc atg tac gag gct gtc aac tac tac gtg ctc aac ccc aag 4409 Ser Gly Gly Met Tyr Glu Ala Val Asn Tyr Tyr Val Leu Asn Pro Lys 1065 1070 1075 1080 tcc atc acg atg ggc cag ctg tac ggg gag ttt gac ctc ctc acc cat 4457 Ser Ile Thr Met Gly Gln Leu Tyr Gly Glu Phe Asp Leu Leu Thr His 1085 1090 1095 gag tgg aca gac ggg ata ttc tcc tcg ttc cgg gcg ggg gcc atc 4505 Glu Trp Thr Asp Gly Ile Phe Ser Ser Phe Ile Arg Ala Gly Ala Ile 1100 1105 1110 acc tcc gac acc aac aag aag tgg tac atg ttc gat ggg ccg gtg gat 4553 Thr Ser Asp Thr Asn Lys Lys Trp Tyr Met Phe Asp Gly Pro Val Asp 1115 1120 1125 gcc atc tgg att gag aac atg aac acg gtg ctg gat gac aac aag aag 4601 Ala Ile Trp Ile Glu Asn Met Asn Thr Val Leu Asp Asp Asn Lys Lys 1130 1135 1140 ctc tg agc tct ggg gag atc atc aag ctc aca gag gca atg acc 4649 Leu Cys Leu Ser Ser Gly Glu Ile Ile Lys Leu Thr Glu Ala Met Thr 1145 1150 1155 1160 atg atg ttc gag gtg caa gac ctg gc g gtg gct tca cca gct aca gtc 4697 Met Met Phe Glu Val Gln Asp Leu Ala Val Ala Ser Pro Ala Thr Val 1165 1170 1175 tcc cgc tgt ggc atg gtg tac ctg gag ccc agc atc ctg ggg ctc atg 4745 Ser Arg Cy Val Tyr Leu Glu Pro Ser Ile Leu Gly Leu Met 1180 1185 1190 ccc ttc atc gag tgc tgg ctg agg aag ctg cct ccc ttg ctg aag ccc 4793 Pro Phe Ile Glu Cys Trp Leu Arg Lys Leu Pro Pro Leu Leu Lys Pro 1195 1200 120 tat gag gag cat ttc aag gcc ctc ttt gtc agc ttc ctg gag gaa tcc 4841 Tyr Glu Glu His Phe Lys Ala Leu Phe Val Ser Phe Leu Glu Glu Ser 1210 1215 1220 atc tcc ttc gtt cgg tcc tca gtg aag gag gtg ag ggt acc aac 4889 Ile Ser Phe Val Arg Ser Ser Val Lys Glu Val Ile Ala Ser Thr Asn 1225 1230 1235 1240 tgc aac ctg acc atg agc ctc ctc aag ctg ctg gac tgc ttc ttc aag 4937 Cys Asn Leu Thr Met Ser Leu Leu Lys Le Leu Asp Cys Phe Phe Lys 1245 1250 1255 ccc ttt ctg cct aga gag ggc ctc aag aaa ata ccc tct gaa aag ctg 4985 Pro Phe Leu Pro Arg Glu Gly Leu Lys Lys Ile Pro Ser Glu Lys Leu 1260 126 5 1270 agt cgc atc gta gag ttg atc gag ccc tgg ttc atc ttc tcc ctg atc 5033 Ser Arg Ile Val Glu Leu Ile Glu Pro Trp Phe Ile Phe Ser Leu Ile 1275 1280 1285 tgg agc gtg ggt gcc act ggg gac agcgt acc agt ttc agc 5081 Trp Ser Val Gly Ala Thr Gly Asp Ser Ser Gly Arg Thr Ser Phe Ser 1290 1295 1300 cac tgg cta agg ctc aag atg gag aac gaa cag ctg act ctg ctt ttc 5129 His Trp Leu Arg Leu Lys Met Glu Asn Glu Gln Leu Thr Leu Leu Phe 1305 1310 1315 1320 cca gaa gag ggg ctg gtg ttc gat tac agg ctg gag gac gcg ggc atc 5177 Pro Glu Glu Gly Leu Val Phe Asp Tyr Arg Leu Glu Asp Ala Gly Ile 1325 1330 acc aac gac agt gag gat gaa gag gag gaa tac aag cag gtt 5225 Ser Gly Thr Asn Asp Ser Glu Asp Glu Glu Glu Glu Tyr Lys Gln Val 1340 1345 1350 gcc tgg gtg aag tgg atg gac tcc tca gct cca ttc acc atg gta cca 5 Ala Trp Val Lys Trp Met Asp Ser Ser Ala Pro Phe Thr Met Val Pro 1355 1360 1365 gac acc aac tac tgc aac atc att gtg ccc acc atg gac acc gtg cag 5321 Asp Thr Asn Tyr Cys Asn Ile Il e Val Pro Thr Met Asp Thr Val Gln 1370 1375 1380 atg tcc cat tta ctg gac atg ctg ctc acc aac aag aag ccc gtg ctg 5369 Met Ser His Leu Leu Asp Met Leu Leu Thr Asn Lys Lys Pro Val Leu 1385 1390 1395 1400 tgc att ggg cca aca ggc acg ggg aag acg ctc acc atc tct gac aag 5417 Cys Ile Gly Pro Thr Gly Thr Gly Lys Thr Leu Thr Ile Ser Asp Lys 1405 1410 1415 ctc ctc aag aac ctg gca ctg gat tac atc agc cac ttc ttc 5465 Leu Leu Lys Asn Leu Ala Leu Asp Tyr Ile Ser His Phe Leu Thr Phe 1420 1425 1430 tca gcc cgc act tca gcc aac cag acc cag gac ttc att gac agc aag 5513 Ser Ala Arg Thr Ser Ala Asn Gln Thr Gln Asp Phe Ile Asp Ser Lys 1435 1440 1445 ctg gac aag agg cgg aag ggt gtg ttt gga cca cct ctg ggg cgc aac 5561 Leu Asp Lys Arg Arg Lys Gly Val Phe Gly Pro Pro Leu Gly Arg Asn 1450 1455 1460 ttt atc ttc gtt atc ctg aac atg ccg gcc ctg gag acc tac 5609 Phe Ile Phe Phe Ile Asp Asp Leu Asn Met Pro Ala Leu Glu Thr Tyr 1465 1470 1475 1480 ggt gca cag cca ccc atc gag ctg ttg cgc cag tgg atg g ac cac ggc 5657 Gly Ala Gln Pro Pro Ile Glu Leu Leu Arg Gln Trp Met Asp His Gly 1485 1490 1495 ggc tgg tac gac cgc aag atc att ggt gcc ttc aag aac cta gtg gac 5705 Gly Trp Tyr Asp Arg Lys Ile Ile Phe Lys Asn Leu Val Asp 1500 1505 1510 atc aac ttt gtc tgt gcc atg ggc ccc ccg ggt gga ggc agg aac acc 5753 Ile Asn Phe Val Cys Ala Met Gly Pro Pro Gly Gly Gly Arg Asn Thr 1515 1520 1525 gtc acc ccg cgg atg cgt cac ttc aac tac ctg tct ttc gct gag 5801 Val Thr Pro Arg Leu Met Arg His Phe Asn Tyr Leu Ser Phe Ala Glu 1530 1535 1540 atg gac gag gtc agc aag aaa cgc atc ttc tcc acc atc ctg ggc aac 58 Glu Val Ser Lys Lys Arg Ile Phe Ser Thr Ile Leu Gly Asn 1545 1550 1555 1560 tgg ttg gat gga ctc ctt gga ga aa aagc tac cgg gag cgt gtg cct 5897 Trp Leu Asp Gly Leu Leu Gly Glu Lys Ser Tyr Arg Glu Arg Pro 1565 1570 1575 ggg gcc ccc cac att gcc cac ttc acg gag ccc ctt gtg gaa gcc acc 5945 Gly Ala Pro His Ile Ala His Phe Thr Glu Pro Leu Val Glu Ala Thr 1580 1585 1590 atc atg gtg tat gca acc atc acc tcc cag ctg ctg ccc act cca gcc 5993 Ile Met Val Tyr Ala Thr Ile Thr Ser Gln Leu Leu Pro Thr Pro Ala 1595 1600 1605 aag tcc cac tac acc ttc aac ctg agg gac ctc tcc aag gtc ttc caa 6041 Lys Ser His Tyr Thr Phe Asn Leu Arg Asp Leu Ser Lys Val Phe Gln 1610 1615 1620 ggc atg ctc atg gct gac ccg gcc aag gtc gag gac caa gtg cag ctg 6089 Gly Met Leu Met Ala Asp Pro Ala Lys Val Glu Asp Gln Gln Leu 1625 1630 1635 1640 ctg cga ctg tgg tat cac gag aac tgc cgc gtg ttc cgg gac cga ctg 6137 Leu Arg Leu Trp Tyr His Glu Asn Cys Arg Val Phe Arg Asp Arg Leu 1645 1650 1655 gtg aatgag gag gag ttc gac cag ctc ctc aag cgc tgc 6185 Val Asn Glu Glu Asp Arg Ser Trp Phe Asp Gln Leu Leu Lys Arg Cys 1660 1665 1670 atg gag cag tgg gag gtg acc ttc aac aag gtc tgc ccc ttc cag Gccln 233 Val Thr Phe Asn Lys Val Cys Pro Phe Gln Pro 1675 1680 1685 att ctt tac ggg gac ttc atg tca cca ggc tcc gat gtc aag tcc tac 6281 Ile Leu Tyr Gly Asp Phe Met Ser Pro Gly Ser Asp V al Lys Ser Tyr 1690 1695 1700 gag ctc atc acc agt gag agt aag atg atg cag gtg ata gag gag tac 6329 Glu Leu Ile Thr Ser Glu Ser Lys Met Met Gln Val Ile Glu Glu Tyr 1705 1710 1715 1720 ata gag gac tac aac cag atc aac acg gcc aag ctg aag ctg gtc ctc 6377 Ile Glu Asp Tyr Asn Gln Ile Asn Thr Ala Lys Leu Lys Leu Val Leu 1725 1730 1735 ttc atg gac gcc atg agc cac atc tgt cgc atc agc cgc Ascc Pc ccc ccc Pc cc ccc Pc cc ccc pcc ccc Pcc Ala Met Ser His Ile Cys Arg Ile Ser Arg Thr Leu Arg 1740 1745 1750 cag gcg ctg ggc aat gca ctc ctg ctg ggc gtg ggt ggc agc ggc cgc 6473 Gln Ala Leu Gly Asn Ala Leu Leu Leu Gly Val Gg 1760 1765 <210> 208 <211> 6295 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3061) <400> 208 g atg acc att gct aca tgt gca aag tgc aaa agt gtt cac aag atc tct 49 Met Thr Ile Ala Thr Cys Ala Lys Cys Lys Ser Val His Lys Ile Ser 1 5 10 15 ctt caa gat ttg cag aag ggt aca ggg aag gac ggt atg tat gtc tgc 97 Leu Gln Asp Leu Gln Lys Gly Thr Gly Lys Asp Gly Met Tyr Val Cys 20 25 30 ttc cag tgc agc ctc ggt gca gct cct ccc aat ttt cat ttt gtg agc 145 Phe Gln Cy Ser Gly Ala Ala Pro Pro Asn Phe His Phe Val Ser 35 40 45 aat aat ccc agt gcg act cat gtt gga aat aaa act gaa aac ttc tca 193 Asn Asn Pro Ser Ala Thr His Val Gly Asn Lys Thr Glu Asn Phe Ser 50 55 60 agt tct gtc aat agc aaa ttt aag gta agg aac ttt aag cca ggc aaa 241 Ser Ser Val Asn Ser Lys Phe Lys Val Arg Asn Phe Lys Pro Gly Lys 65 70 75 80 tac tat tgt gat aaa tgt cga ttc tct aca aag gac ccg ctg cag tac 289 Tyr Tyr Cys Asp Lys Cys Arg Phe Ser Thr Lys Asp Pro Leu Gln Tyr 85 90 95 aaa aag cac acc ctt caa cac gag gag att aaa ttc att tgt tct cac 337 Lys Lys His Thr Leu Gln His Glu Glu Ile Lys Phe Ile Cys Ser His 100 105 110 tgc agc tac att tcg tat acg aaa gga gag ttt cag agg cat ttg gtg 385 Cys Ser Tyr Ile Ser Tyr Thr Lys Gly Glu Phe Gln Arg His Leu Val 115 120 125 aaa cac aca ggc ata ttt cct tat cag tgt gag tat tgt gac tat ggt 433 Lys His Thr Gly Ile Phe Pro Tyr Gln Cys Glu Tyr Cys Asp Tyr Gly 130 135 140 gct att aga aat gat tat att gtc aaa cac acg aag aga gta cat gaa 481 Ala Ile Arg Asn Asp Tyr Ile Val Lys His Thr Lys Arg Val His Glu 145 150 155 160 agg gca ggt gcg aaa cgg cca gtc aaa gct gtt gcc aag ctg gag cca 529 Arg Ala Gly Ala Lys Arg Pro Val Lys Ala Val Ala Lys Leu Glu Pro 165 170 175 aaa aaa aga acc gga act tca aaa caa aac cca gag ctt cta aaa gct tcc 577 Lys Arg Thr Gly Thr Ser Lys Gln Asn Pro Glu Leu Leu Lys Ala Ser 180 185 190 aat cca cgg act aca ttt caa aat aag tgg tca gac caa ctg tca ggt 625 Asn Pro Arg Thr Thr Phe Gln Asn Lys Trp Ser Asp Gln Leu Ser Gly 195 200 205 ttc tct ctc cat gca aat aaa gac aaa atg cac aat atc atg ttg tta 673 Phe Ser Leu His Ala Asn Lys Asp Lys Met His Asn Ile Met Leu Leu 210 215 220 cct gaa cca aag gaa tac caa aaa gat gta gtt tgt att cca aat aaa 721 Pro Glu Pro Lys Glu Tyr Gln Lys Asp Val Val Cys Ile Pro Asn Lys 225 230 235 240 atg acc ctg tct gag cca aat gaa gtc aac cta ttt gag aac aaa aat 769 Met Thr Leu Ser Glu Pro Asn Glu Val Asn Leu Phe Glu Asn Lys Asn 245 250 255 gtt gaa gta gaa gtg tta tcc cct gca aaa gaa cct gtt cag cca ggt 817 Val Glu Val Glu Val Leu Ser Pro Ala Lys Glu Pro Val Gln Pro Gly 260 265 270 atg cca ttg aca gtt gtt gca cca gca gaa cta gtt gtc cct gca aac 865 Met Pro Leu Thr Val Val Ala Pro Ala Glu Leu Val Val Pro Ala Asn 275 280 285 285 tgt tta gcc cag ttg ata gac gtg aag gtt gtc aat ggt aca cag cag 913 Cys Leu Ala Gln Leu Ile Asp Val Lys Val Val Asn Gly Thr Gln Gln 290 295 300 ctt gtt ctg aaa ctg ttt ccg ctg gaa taga gct 961 Leu Val Leu Lys Leu Phe Pro Leu Glu Glu Asn Asn Cys Leu Glu Ala 305 310 315 320 ggg agg gat aat gga ggt aat tct gaa cgt atg gtg aaa gag aag ggt 1009 Gly Arg Asp Asn Gly Gly Asn Ser Glu Arg Me t Val Lys Glu Lys Gly 325 330 335 tca aat gaa caa gaa aaa gta ctt tct gca gaa aaa aca aag tca ctg 1057 Ser Asn Glu Gln Glu Lys Val Leu Ser Ala Glu Lys Thr Lys Ser Leu 340 345 350 350 aca gtt gac ggg aat gtt gga aaa ctc gta ggc att gat agt ttt caa 1105 Thr Val Asp Gly Asn Val Gly Lys Leu Val Gly Ile Asp Ser Phe Gln 355 360 365 cct tca gtt cag aaa cag ctt aaa aat gtg aaa tgg gta agg tct tat 1153 Pro Ser Val Gln Lys Gln Leu Lys Asn Val Lys Trp Val Arg Ser Tyr 370 375 380 gat ttt att atg cca aat tct agt gtg cac aac aat gga aaa tcc ttc 1201 Asp Phe Ile Met Pro Asn Ser Ser Val His Asn Asn Gly Lys Ser Phe 385 390 395 400 att aat tcg gaa aca att gag gat ttt cag aaa aaa aat aat ttg tat 1249 Ile Asn Ser Glu Thr Ile Glu Asp Phe Gln Lys Lys Asn Asn Leu Tyr 405 410 415 cca cat aga act gct ttt cct tcc gtt gcc tta aaa ggt cat tct cta 1297 Pro His Arg Thr Ala Phe Pro Ser Val Ala Leu Lys Gly His Ser Leu 420 425 430 gca tct gta ttt aaa aac agt gtt tta cgt agt ctt gga gct gca tca 1345 Ala Ser Val Phe Lys Asn Ser Val Leu Arg Ser Leu Gly Ala Ala Ser 435 440 445 aac cct ttt cca tat aaa gct gct gtt tgt ttt gct gaa agt gga aga 1393 Asn Pro Phe Pro Tyr Lys Ala Ala Val Cys Phe Ala Glu Ser Gly Arg 450 455 460 aat tta cac agt aac tca cag cag tta ctc cca ttt gct gca tca cct 1441 Asn Leu His Ser Asn Ser Gln Gln Leu Leu Pro Phe Ala Ala Ser Pro 465 470 475 480 480 gca acc tgt tcc ttc tct gga gaa aag ggc tta ttg cct agt gaa 1489 Ala Thr Cys Ser Phe Ser Gly Glu Lys Gly Leu Leu Pro Val Ser Glu 485 490 495 aat gac ttg gaa tct aca agt aaa aaa gtc aat att cct gta aaa gtg gtt 1537 Asn Asp Leu Glu Ser Thr Ser Lys Val Asn Ile Pro Val Lys Val Val 500 505 510 tcc tct aat agg aag cag gaa gat aac cag aca gag gaa cac aag gca 1585 Ser Ser Asn Arg Lys Gln Glu Asp Asn Gln Thr Glu Glu His Lys Ala 515 520 525 gtt tca act gta ggc cag att tcc tct caa cat aag agt gag tat tta 1633 Val Ser Thr Val Gly Gln Ile Ser Ser Gln His Lys Ser Glu Tyr Leu 530 535 540 cat ata aac ata act gga gaa gat aga tct caa cag cct ggg gat aag 1681 His Ile Asn Ile Thr Gly Glu Asp Arg Ser Gln Gln Pro Gly Asp Lys 545 550 555 560 cct ttg gaa tta aag aat tct gaa agg act aac aac act aat gat ggc 1729 Pro Leu Glu Leu Lys Asn Ser Glu Arg Thr Asn Asn Thr Asn Asp Gly 565 570 575 cca gtc atc tca tca gta ttt tct ctg agc tct gga tct gaa aat gtc 1777 Pro Val Ile Ser Ser Val Phe Ser Leu Ser Ser Gly Ser Glu Asn Val 580 585 585 590 ccc gag ggc att aag tgg aat agc tca acg tct aaa ata aag tca att 1825 Pro Glu Gly Ile Lys Trp Asn Ser Ser Thr Ser Lys Ile Lys Ser Ile 595 600 605 gaa ctg ttg cgc aga aag ata gct cag tta att gag tcc tgt ggg aag 1873 Glu Leu Leu Arg Arg Lys Ile Ala Gln Leu Ile Glu Ser Cys Gly Lys 610 615 620 ccg tca tct ttg gct tca aat agt gca cat cgt cgc tct gta ggg cag 1921 Pro Ser Ser Leu Ala Ser Asn Ser Ala His Arg Arg Ser Val Gly Gln 625 630 630 635 640 gca tca aag gga act tca aaa gct acc tct gaa ggt att caa gaa atc 1969 Ala Ser Lys Gly Thr Ser Lys Ala Thr Ser Glu Gly Ile Gln Glu Ile 645 650 655 aac gtg tca ctc act ggt ctt ggc cat tcc aca ggt a ct ctt cag aaa 2017 Asn Val Ser Leu Thr Gly Leu Gly His Ser Thr Gly Thr Leu Gln Lys 660 665 670 cct ccg aat gat ggt ggt att act ggt aat aga cag ctt act cat caa 2065 Pro Pro Asn Asp Gly Gly Ile Thr Gly Asn Arg Gln Leu Thr His Gln 675 680 685 caa ata tat cca cac ttt gca gat ggc agt aat agg aaa acc aaa agc 2113 Gln Ile Tyr Pro His Phe Ala Asp Gly Ser Asn Arg Lys Thr Lys Ser 690 695 700 aga gtg gcc agg aag gct cat gtt gcc acg cca gtg tta atc ccc aaa 2161 Arg Val Ala Arg Lys Ala His Val Ala Thr Pro Val Leu Ile Pro Lys 705 710 715 720 ggg gct gtg ttg agg gtt ctt aat tcc tct gag aat gcc cac atc ata 2209 Gly Ala Val Leu Arg Val Leu Asn Ser Ser Glu Asn Ala His Ile Ile 725 730 735 gag gct aca tgt gaa gca cct gtc agc ata cct tgc agt gaa aga cag 2257 Glu Ala Thr Cys Glu Ala Pro Val Ser Ile Pro Cys Ser Glu Arg Gln 740 745 750 tta ata aaa cca gtt cca ttt tgc cct gtg aga cag gcg gac tca gac 2305 Leu Ile Lys Pro Val Pro Phe Cys Pro Val Arg Gln Ala Asp Ser Asp 755 760 765 tta cag cct tta aga agt gaag g ggg cca ata gat atg tcc cca aat 2353 Leu Gln Pro Leu Arg Ser Glu Arg Gly Pro Ile Asp Met Ser Pro Asn 770 775 780 atc gag aca cct ctg cgg cct aaa ctg aga aaa gag agt gct gtc tgt 2401 Ile Glu Thr Pro Leu Arg Pro Lys Leu Arg Lys Glu Ser Ala Val Cys 785 790 795 800 agc acc atc cat aga aaa act ggc ctc ttg tat gga cag caa gga agc 2449 Ser Thr Ile His Arg Lys Thr Gly Leu Leu Tyr Gly Gln Gln Gly Ser 805 810 815 agt gaa tta aat aag caa ggg aga ctg ctt tcc aga agt ctt tct ata 2497 Ser Glu Leu Asn Lys Gln Gly Arg Leu Leu Ser Arg Ser Leu Ser Ile 820 825 830 agt aga aat aaa acc aaa caa gta cac tta tcc agg aag aaa aac aaa 2545 Ser Arg Asn Lys Thr Lys Gln Val His Leu Ser Arg Lys Lys Asn Lys 835 840 845 att caa gct gaa cct agc cgc tgt ctc aag gat cct tca att ttt cag 2593 Ile Gln Ala Glu Pro Ser Arg Cysu Lys Asp Pro Ser Ile Phe Gln 850 855 860 gtt gca agg caa cta aga ctg ata gca gct aag cca gat cag ttg att 2641 Val Ala Arg Gln Leu Arg Leu Ile Ala Ala Lys Pro Asp Gln Leu Ile 865 870 870 875 880 aag tg t ccc cgt cgg aac cag cca gtc att gtg tta aac cac cct gat 2689 Lys Cys Pro Arg Arg Asn Gln Pro Val Ile Val Leu Asn His Pro Asp 885 890 895 gtg gac tcg cca gaa gtg acc aat gtg atg aag gta ataat tac 2737 Val Asp Ser Pro Glu Val Thr Asn Val Met Lys Val Ile Asn Lys Tyr 900 905 910 aaa ggc aat gtc ctc aaa gtt gtt tta tca gag agg act agg tgt cag 2785 Lys Gly Asn Val Leu Lys Val Val Leu Ser Glu Arg Thr Arg Cys Gln 915 920 925 cta ggc atc aga cgg cat cat gta cgc ctg acc tac cag aat gcg gaa 2833 Leu Gly Ile Arg Arg His His Val Arg Leu Thr Tyr Gln Asn Ala Glu 930 935 940 gaa gcc agt caa agg aaa agg caa atg atg ttg aaa atg aaa ctc aaa 2881 Glu Ala Ser Gln Ile Lys Arg Gln Met Met Leu Lys Met Lys Leu Lys 945 950 955 960 aaa gtt cat aaa aac aac tac cag gta gtg gat tcc ttg cct gat gat 2929 Lys Lys Asn Asn Tyr Gln Val Val Asp Ser Leu Pro Asp Asp 965 970 975 tct tca cag tgt gta ttt aag tgc tgg ttt tgt ggg cga ctg tat gaa 2977 Ser Ser Gln Cys Val Phe Lys Cys Trp Phe Cys Gly Arg Leu Tyr Glu 980 985 990 gac cag gaa gag tgg atg agt cat ggc caa cgg cat ttg ata gaa gca 3025 Asp Gln Glu Glu Trp Met Ser His Gly Gln Arg His Leu Ile Glu Ala 995 1000 1005 act aga gat tgg gat gtt ctt tcc tcc aaggg aaa taagtaaaca 3071 Thr Arg Asp Trp Asp Val Leu Ser Ser Lys Gly Lys 1010 1015 1020 gttactcttt aaagcaagtt atcttttagt ttattctggt ttggagtccc tccaccaaga 3131 ttcagtagaa gaaatacaga ctgtagaaat gagaggactg ctaattcttc agaactgtag 3191 gaatattggg agctaggagt ctgaacctga agtatgtgat tggaccccag aatgtatttg 3251 aaggctctga aattgtacat gcaaattggt acatatgcat ttttctggag agagcctgtg 3311 aaactgaaca gattttcagt gggatctgag acttttcttt gtttagcacc ccgttttctg 3371 agtacatact gatctttcat aatccattca gaggggcaga ttgagaatgt tttacacatg 3431 ctcttcatat aaatgctaca gaaaaacctt tgttttggtg tgcacatcca ttttgttttt 3491 gctttaattt gtgttctgag tatttggtgc acaatggaaa ttatattttc tactttactg 3551 tcttcaattt ggttatagag aaatggccat tcttttactc cctccctggt tttgtaatac 3611 tcccgagtgt tccgtatagc acaaagagtt ttgcttttac tggccatttt aaagaatgtt 3671 tt caactgct tgcctgaatt tactcctttc acagcaagtg ttagaagaaa gataacattt 3731 tcaaatactt agcttttgct ttctttaaaa tacattggtt tatgacatat gggaagggaa 3791 cgtacctttt tgcaaagaca aaaagagatt acaaaaggaa aatatctaaa actattttct 3851 ctttgccctt accactccca gaaacataag tgaccaattt aaaatgctag ggaacaggct 3911 tacaacatag gtaaaactcg caaacacagt tcaaggtagg ctcataaagt tgtgaaaagg 3971 gtttcatatg ccctttagtt ttcatttggg attcatccaa agaccatggg tggatgctgt 4031 cttctctctt cttgatccct ttgattcatg gacactagac tccctttgcc atttcttctg 4091 aaccggccct cctgtggact agcacaactt ccttgcccac tgtttcttcc tttctgtgcc 4151 tttgagaccc cttaaggttt tccctcatgc gattactaga aaatggcagg aatcaacaaa 4211 atggagacct cccactgttt ttgctaaagt tacaggaaca cgatccctag ttttcattga 4271 tagtaacgct gtttctaatt tgtcttaacc acattcatgc ttaccctgct gctcagcttt 4331 ctcagggaag caactccagg aacactcctt ccactcccct ctctaccaac agatgtcagg 4391 actgtcattt atctacacat ttgtgttctt tagaaaaagg cccaccccct gcacaagcac 4451 agcctcttgg gcagataggt ggctgggtca gtgcttaaga caggattcta gtcttcactt 4511 gcctgtgc ag ctgggcgctg accttccagg tagagcacag atggcacaac cccgaggcag 4571 ccccaacttg catttccctc cctccagggg ctattcctgt cttaggcgat ttgtggggtg 4631 cagtgaatga aactaaagag ttgttgcacc tgaaaaagac accagtgatt gtttattggg 4691 tagtcgattg gagactttga tttttttttt tttttttttc acatgggaaa gtcttagatt 4751 ccagtagatg gaattgcaat cctttgcagt ttgttctcat tacagataat caacatttct 4811 tttgtataat tcaatacatg atcatcaagt taattggtaa atttttattg aaatttaaaa 4871 cttgcatttt tatatatgtg tatgtgtaca cataaaaata ttttttacca tatgaaaatt 4931 gcagtagcta attttctgat ttcctatttt ataatgatac atgggctgga aaaatgtaga 4991 acgtttttat attctagaaa tttattttgg aagtacattt ttataagggt ctaatctcac 5051 ttttggaaaa tgaaagcaca ggaatgatgg ggtctggttt atgtgaacaa gtgagtagaa 5111 acccctttgg atcattttat tactgcattt ttatttggtg ctttttagga agtagatctt 5171 tggtaccact tcactacgta aagtagagca ttcgaagttt tatccatgtt atatattgta 5231 ctcctgtggc atgaaaaata gctcccaaga tatagagagg agaggagtga agaaaaggct 5291 gtggtttttt tttgttttgt tttgtttgcc acttttttat ctcctattcc tcaccacata 5351 gtgctttttc ct gaaaagct ggactgagaa ttggccttga atcaggtcag agtgttaact 5411 gtcaacatga agtattttca cttcgcagca tcaactttca agcataagta aaaacacaac 5471 ttgcatactt tgatggagct taattgtgtg agtagaatat gtagcaaagc tttttaggat 5531 tttcagaact agaatacttt ttaaggaatt aaaagtgttt ctggaagtca aaaatgggaa 5591 agcaaaaagt agctgtcctc cctaaagagc tttagaagat agcttaacct gtaggtacat 5651 gttatgaaat aaacacattt ctaacaatac aagggagtag gggcagacct gtgttgagta 5711 tttgtgtggg ttcttaattt tgaaggacct ccaatcacta cattttgtta atactgccaa 5771 taaaatcatt ttcaacttat tttttaaagt aggttttctt actttggtgg accagaagtg 5831 agagattgtt atatttagga tataggcaaa tacagtaaaa gttaaaaaaa aaaaaagctg 5891 acccaaagta tactctgata gactatatta tattcaattt tgtatcccca gtcgagaaca 5951 tcttgtaagc cttcattaag ggccacctgc tgtctgttga actagactga acaaaatata 6011 ttttctcaca agctccatcc ctttttcttt aggacatgtt atatataatc catctcagaa 6071 gttgaagatg tgatgttgct cggcctttgg aataattttt aaatctgtaa atgtctatat 6131 gagcagaaac aaaacattgt gtaacatgtt ttaagcatta ttgtaattcc tgtgttaaca 6191 gtttgtgtgt ctgctgct ct ggttttgaaa catgtttgta tatagataca ggagttggca 6251 taaattttgt taaataaagc aacaaaaatt ttctttgccc tttg 6295 <210> 209 <211> 6404 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (17) .. (2377) <400> 209 tacgcttcta gcttga ggg aaa gag gcc gag gcc tgg gcc aag ccc gga gcc 52 Gly Lys Glu Ala Glu Ala Trp Ala Lys Pro Gly Ala 1 5 10 gcc gct cgc cgg agc ctc ctg gag cct ccg cgccgg gg 100 Ala Ala Arg Arg Ser Leu Leu Glu Pro Pro Arg Arg Leu Ser Leu Gly 15 20 25 gcg ggc tcc ggt ccg gcc cgc cgc cgc acc cag gac gga ggc tgc atg 148 Ala Gly Ser Gly Pro Ala Arg Arg Arg Thr Gln Asp Gly Gly Cys Met 30 35 40 ccc gag gac cag gcc ggc gca gcc atg gag gag gcg tct ccc tat tcc 196 Pro Glu Asp Gln Ala Gly Ala Ala Met Glu Glu Ala Ser Pro Tyr Ser 45 50 55 60 tta ctt gat atc tgc ttg aat ttc ttg act act cac ctt gag aag ttc 244 Leu Leu Asp Ile Cys Leu Asn Phe Leu Thr Thr His Leu Glu Lys Phe 65 70 75 tgt tca gcc aga caa gat gga aca ttg tgt ctg cag gaa cct gga gta 292 Cys Ser Ala Arg Gln Asp Gly Thr Leu Cys Leu Gln Glu Pro Gly Val 80 85 90 ttc cca cag gag gtg gct gat cga ctg ctt cgg acc atg gct ttt cat 340 Phe Pro Gln Glu Val Ala Asp Arg Leu Leu Arg Thr Met Ala Phe His 95 100 105 ggt cta ttg aat gat gga act gtg ggt att ttt agg ggc aac cag atg 388 Gly Leu Leu Asn Asp Gly Thr Val Gly Ile Phe Arg Gly Asn Gln Met 110 115 120 cgc tta aag cga gcc tgc att cgc aaa gca aag atc tct gct gtt gct 436 Leu Lys Arg Ala Cys Ile Arg Lys Ala Lys Ile Ser Ala Val Ala 125 130 135 140 ttc cgg aaa gct ttc tgc cac cac aag tta gtg gaa ctt gat gcc aca 484 Phe Arg Lys Ala Phe Cys His His Lys Leu Val Glu Leu Asp Ala Thr 145 150 155 ggt gtg aat gct gat atc acg att aca gac att atc agt ggg ctt ggc 532 Gly Val Asn Ala Asp Ile Thr Ile Thr Asp Ile Ile Ser Gly Leu Gly 160 165 170 agt aac aaa tgg atc cag cag aat ctc cag tgc ctg gtg ctg aat tca 580 Ser Asn Lys Trp Ile Gln Gln Asn Leu Gln Cys Leu Val Leu Asn Ser 175 180 185 tta act ctc tcc ctc gag gat cct tac gag cgc tgc ttc agc cgg ctt 628 Leu Thr Le Asp Pro Tyr Glu Arg Cys Phe Ser Arg Leu 190 195 200 tct ggc ctt cga gct tta agc atc acg aat gtt ctc ttt tac aat gaa 676 Ser Gly Leu Arg Ala Leu Ser Ile Thr Asn Val Leu Phe Tyr Asn Glu 205 210 215 220 gac ctg gct gaa gtt gcc tca ttg cca aga tta gag agc ttg gat att 724 Asp Leu Ala Glu Val Ala Ser Leu Pro Arg Leu Glu Ser Leu Asp Ile 225 230 235 tct aac acc tca atc aca gac atc act gct cta ctg gcc aaa gac 772 Ser Asn Thr Ser Ile Thr Asp Ile Thr Ala Leu Leu Ala Cys Lys Asp 240 245 250 cga ctc aag tct cta acc atg cac cac ttg aaa tgt tta aaa atg aca 820 Arg Leu Lys Ser Leu Thr Met His His Leu Lys Cys Leu Lys Met Thr 255 260 265 act acc cag ata ctg gat gta gtt cgg gaa ctc aaa cat ctg aat cat 868 Thr Thr Gln Ile Leu Asp Val Val Arg Glu Leu Lys His Leu Asn His 270 275 280 ctt gat atc tca gat gat aaa cag ttt aca tca gac ata gct ctt cgc 916 Leu Asp Ile Ser Asp Asp Lys Gln Phe Thr Ser Asp Ile Ala Leu Arg 285 290 295 300 tta cta gaa caa aaa gac atc cta cct aac ctt gtt tct ctg gat gtt 964 Leu Glu Gln Lys Asp Ile Leu Pro Asn Leu Val Ser Leu Asp Val 305 310 315 tct ggg aga aag cac gtg aca gat aaa gcc gtt gaa gcc ttt ata caa 1012 Ser Gly Arg Lys His Val Thr Asp Lys Ala Val Glu Ala Phe Ile Gl n 320 325 330 caa cgt cca agc atg caa ttt gta ggt ttg ctg gct act gat gct ggt 1060 Gln Arg Pro Ser Met Gln Phe Val Gly Leu Leu Ala Thr Asp Ala Gly 335 340 345 tac tct gaa ttc ctc aca ggc gaga g ttg aag gtg tct ggg gaa 1108 Tyr Ser Glu Phe Leu Thr Gly Glu Gly His Leu Lys Val Ser Gly Glu 350 355 360 gcc aat gaa act cag att gca gaa gca ctg aag cgt tac agt gaa cgg 1156 Ala Asn Glu Thr Gln Ala Glu Ala Leu Lys Arg Tyr Ser Glu Arg 365 370 375 380 gca ttc ttt gtt cgg gaa gct cta ttt cat ctt ttt agt ctg act cat 1204 Ala Phe Phe Val Arg Glu Ala Leu Phe His Leu Phe Ser Leu Thr His 385 390 395 gtg atg gaa aaa aca aag cca gaa att tta aag ctt gtg gtt act ggg 1252 Val Met Glu Lys Thr Lys Pro Glu Ile Leu Lys Leu Val Val Thr Gly 400 405 410 atg aga aac cac cct atg aat ttg cca gtg caa ctg gct gcag gcc 1300 Met Arg Asn His Pro Met Asn Leu Pro Val Gln Leu Ala Ala Ser Ala 415 420 425 tgt gta ttt aac tta acc aag cag gat ctt gct gca ggg atg cct gtc 1348 Cys Val Phe Asn Leu Thr Lys Gln Asp Leu Al a Ala Gly Met Pro Val 430 435 440 cga ctc ctg gct gat gtg acc cat ttg ctg ctc aaa gcc atg gaa cat 1396 Arg Leu Leu Ala Asp Val Thr His Leu Leu Leu Lys Ala Met Glu His 445 450 455 460 ttt ccc aat cac cag cag tta cag aag aat tgc ctc ctt tca ctt tgc 1444 Phe Pro Asn His Gln Gln Leu Gln Lys Asn Cys Leu Leu Ser Leu Cys 465 470 475 475 agt gac cgg atc ctt caa gat gtt cca ttt aac agg ttt 1 gaa gca gcc Asp Arg Ile Leu Gln Asp Val Pro Phe Asn Arg Phe Glu Ala Ala 480 485 490 aag ctt gtc atg cag tgg ctt tgc aac cat gag gat caa aac atg caa 1540 Lys Leu Val Met Gln Trp Leu Cys Asn His Glu Asp Gln Asn Met Gln 495 500 505 agg atg gca gtt gct atc att tct atc ctg gct gcc aag ctt tct aca 1588 Arg Met Ala Val Ala Ile Ile Ser Ile Leu Ala Ala Lys Leu Ser Thr 510 515 520 gaa caa act gca cag ctt ggt act gag ctc ttc att gtc agg caa ctt 1636 Glu Gln Thr Ala Gln Leu Gly Thr Glu Leu Phe Ile Val Arg Gln Leu 525 530 535 540 ctt caa ata gtg aag cag aaa acc aat caa aat tca gtg gac act aca 1684 Leu Gln Ile Val Lys Gln Lys Thr Asn Gln Asn Ser Val Asp Thr Thr 545 550 555 ttg aaa ttt act ttg agt gca ctt tgg aac ctc aca gat gaa tct cca 1732 Leu Lys Phe Thr Leu Ser Ala Leu Trp Asn Leu Thr Asp Glu Ser Pro 560 565 570 acc act tgt aga cac ttt att gaa aac caa ggg tta gaa ctc ttc atg 1780 Thr Thr Cys Arg His Phe Ile Glu Asn Gln Gly Leu Glu Leu Phe Met 575 580 585 agg gtt cta gag tct ttc cca act gag tca tcc att ca aaa gtt 1828 Arg Val Leu Glu Ser Phe Pro Thr Glu Ser Ser Ile Gln Gln Lys Val 590 595 600 cta gga ctt ttg aac aat ata gct gaa gta caa gaa tta cat tct gaa 1876 Leu Gly Leu Leu Asn Asn Ile Ala Glu Val Gln Glu Leu His Ser Glu 605 610 615 620 tta atg tgg aaa gat ttt ata gac cac atc agt agt ctc cta cac agt 1924 Leu Met Trp Lys Asp Phe Ile Asp His Ile Ser Ser Leu Leu His Ser 625 630 630 635 gtg gaa gtg gag agt tac ttt gca gct gga att att gcc cat tta 1972 Val Glu Val Glu Val Ser Tyr Phe Ala Ala Gly Ile Ile Ala His Leu 640 645 650 ata tcc aga ggt gaa caa gct tgg aca ttg agt cgt agc cag agg aat 2020 Ile Ser Arg Gly Glu Gln Ala Trp Thr Leu Ser Arg Ser Gln Arg Asn 655 660 665 tct ctg ctg gat gat ttg cat tca gct att ttg aaa tgg cca act cca 2068 Ser Leu Leu Asp Asp Leu His Ser Ala Ile Leu Lys Trp Pro Thr Pro 670 675 680 gag tgt gag atg gta gca tac agg tcc ttt aat cca ttt ttc cca tta 2116 Glu Cys Glu Met Val Ala Tyr Arg Ser Phe Asn Pro Phe Phe Pro Leu 685 690 695 700 ctt ggc tgt ttc aca aca cca gga gtt cag cta tgg gca gtt tgg gcc 2164 Leu Gly Cys Phe Thr Thr Pro Gly Val Gln Leu Trp Ala Val Trp Ala 705 710 715 atg caa cat gtc tgc agc aag aat cct tca agg tat tgc agc atg ctg 2212 Met Gln His Cys Ser Lys Asn Pro Ser Arg Tyr Cys Ser Met Leu 720 725 730 att gaa gaa gga gga ttg cag cat tta tac aac atc aaa gat cat gaa 2260 Ile Glu Glu Gly Gly Gly Leu Gln His Leu Tyr Asn Ile Lys Asp His Glu 735 740 745 cat act gat ccc cat gtc caa cag att gct gtg gcc att ctg gat agc 2308 His Thr Asp Pro His Val Gln Gln Ile Ala Val Ala Ile Leu Asp Ser 750 755 755 760 tta gaa aaa cac att gtg cgc cat ggg agg cca cct c cc tgt aaa aaa 2356 Leu Glu Lys His Ile Val Arg His Gly Arg Pro Pro Pro Cys Lys Lys 765 770 775 780 cag ccc caa gcc aga cta aat tgatagccat aagtattgga tagttgaatc 2407 Gln Pro Gln Ala Arg Leu Asn 785 acaggttttt tt acaggatgtttt tt acttgattttt 2467 ggtttctatg acaagagtca taaaatcagt ttgggattga taatgtgtag tactgcccat 2527 gtgaacagtc tctaatttgt cttgtgattt taaacttatg agtcaagaag ggtctcttcc 2587 tttatcattg ccttttagga aattttccac atctttcagt gtttgaactt acttgtgctt 2647 gagattctac agttttatgg taaagtttgc acgaaccctt aggccagact tttctgatct 2707 cagagtccct tccaatcaat ttgcagcttc acataagctg ttgacctgat ttctgacact 2767 gcttcagttg taaattttat actgcttctg tataaaatgc ctttcttctc tatctgtgta 2827 tattttataa gatgtccttc ttagtgtgaa agaagggaaa tgtggatcat cttgtggaag 2887 ctaatcactg gcaggagcct ggatggctgg cggaaagata tatgagaaag aaaaattatg 2947 aaggtagaac agagtgtagg aactgggaat tggtttcatg gtataggttt taaaatgaga 3007 caggctaccc ttcgggagtc ttcgggagtc cacctctctt gaggcgtc gagag ctag gctag gctag ctag ctgctggttc ctgcacagac tgccggttat tcactaggaa 3127 tatttcccca agcaccacag tataaaatac tacagcactc tgtgttaaag actaactgtc 3187 tacatctcca tatgttgtag tgttgtgaaa atgtgatttt aaaaaattat cgccagttaa 3247 aactggctat tcttttcctc tatttcaaag tcatttttgt tcagtggaat agagacagca 3307 acatggtgtt aacctctcaa ttaaaataca attgacacca gtaaattttg ccataaaaag 3367 ttaaaatctc ttgttcaaaa tatgtgtatc ttcttaatgt gttcatgtta gagaaagtgt 3427 ccccatctca ctgccaaaaa tgaaagaaaa taattaaact ctttaaatga ttaaatgtaa 3487 tgattctact cgcagtgcat aacagcacat atttttgaca gattattttt taggcaatta 3547 cctttcctta aggtatctga tacagtatag taaagaatca cttatatcag taatagcact 3607 tgagagatag caagtcacca agaaacttaa ttttcattta aaattttatt ttgtgaataa 3667 ggtcaatcta caatcccaga taactacatt ttttttcata gatggccagt gttttcaaca 3727 gagatttaaa atggaatatt aaaattatag tgattattca gaagcatttt aatttagaaa 3787 ggagctggtt tgttagttca ctgatgacat tttttgacaa acattttata ccattatcac 3847 aataatcaga cttgaatttt ttttggagtt ccttcatgtg aatgaaaact gagttaaaag 3907 aaagtaggca tttaggtctg gatg cagtgg ctcgtgcttg tgatcccagc actttgggaa 3967 gctgaagcag gaggattgct tgagcccgga agttcgagac tagcctgggc aacatagtga 4027 gactcggtct ctaccaaaaa aaaaaatttt ttttttttta aattagctgg gtgtggtggc 4087 acctgggaaa cagagcgaga cgctgactca aataaatatc taaatagata tttagaatca 4147 ctgaaaacca tattaaatgc tgggttaatg ctgacttaat tggcttaagg aatttttata 4207 ggcgtaagat aaattttcac agactaagtt tatttcagac aaaatagaga attcttttaa 4267 aagttttttt ttttttttcc tttttcgaat gttaatgtct aagacaaagt tcagaaaacg 4327 agatggcctg tggtagtttg gaaattgcta gatatgttga ccgtttccag gtcttttatc 4387 tagtgtagtt aagggaaagc ctatttaaga agtttggctt caagtttctg ttttataaga 4447 caaaagtgca tatttcttta caggctaatg ctaggttttt gtctttacaa attattttca 4507 gaaatggcta aaagtgtaca gaaaacagta aatcccttct ttactcagaa taacttctta 4567 atagttgaag catccaaaat atgtaaaagc aagggtgggc gtagtggctc ttgcctgtga 4627 tcccagcatt ctgggaggcc ggggcgggca gatcacttga gatcaggagt tcgagaccac 4687 cctggccaac gtggtgaaac cccgtctcta ctaaaaatac aaaaactagc tgggcatggt 4747 ggcttttttg cacgcctgtg gtcccagcta ctcgggaggc tgaggcacga gaatcacttg 4807 aacccaggaa gtggaggttg cagtgagcta ggatcgtgcc actgcactcc agcctggaca 4867 acggagtgag actctgggga aaaaaaaaat taaacttcct actttttttc tttttgtaga 4927 gacggagttt cactctgtcg cccaagctgg agtgcagtgg cacaatcata cctcactgca 4987 gcctcttggg cttatgtgat cttaccccct cagcctctgg agtagctgga actacaggct 5047 aaatttccta ctttgtaaac atcagtagtg gccagatact tctgagtctt aaaagcataa 5107 taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggtgggtg 5167 gatcacaagg tcaggagttc aagaccagcc tggcccaaat ggtgaaaccc tgtctctact 5227 aaatatacaa aaattagctg ggtgtggtgg cgggcacctg taatcccagc tactcaggag 5287 gctgaggcag gagaatcgct tgaacctggg aggtggaggt tgtggtgagc caatatcatg 5347 ccactgcact ccagcctggg tgacggagtg agactccgtc tcaaaaaaaa aaaaagcata 5407 ataatttatt acatcccaaa tatataaaaa tttgagtgcc tttgcagttg ggatggttcc 5467 taaaattgcg tatagaatta aggcacagaa ttgtgtgtaa ggtcctgaat ctggctaaaa 5527 tacagtggat gtatgtattg gaattatgag gcataagtag ccagtatcta tagttagaat 5587 ctacaaggcc tcctttttgc acctgtagac taga atataa ctgttattgg tgcctttgag 5647 tgttatctct cagtggctag aggtgctgtt tcaagcacaa tttagactag ggttgaacca 5707 ctcattgttc aaatcattgg tgggctccaa tgtaaaatat cactacatca gtccacaagc 5767 aacattaagg aaatctaaag gaaatggaat ttgacttttt agagtataat gatgttctag 5827 ggcataatga ggaaaatttt taaaaaatag attataatga tacatattgg tatcattaag 5887 acaacagatt tgagcaaata caattaaggt gtcttatttt ttgcatcaag taattattgc 5947 tgtggtcttt ctactccaca aaataatttt ttctttttgc agttgaaaat taactgcatt 6007 attaactaat taataaaata aatcaagtgg tataagggat tagtttaccc tcaagccgat 6067 gactccatgg ctactgatat tagttagttt aggattttta aaaagcatat cagaccccca 6127 gtttcaggaa ttgagtataa atattgcttc ttgtcaccct gggacagtaa tgccttatag 6187 tggcactagt caccttaagt agattacaca tggttgaggt gaataaagct gcatgggaat 6247 ttgctttcgt gatatatttc atttgcaaac ttctacataa tcaagtttta tgtttaaaac 6307 catcggttct atatatctag ctttaggaag ttgcccttac aggtgggacc ttttgtgtta 6367 atctgttttc tccccagtca tcttatttgg ctatgtt 6404 <210> 210 <211> 5401 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (4550) <400> 210 ct gtt agt gaa att gag agt aaa gca cca acg gtt gag tca gga aca 47 Val Ser Glu Ile Glu Ser Lys Ala Pro Thr Val Glu Ser Gly Thr 1 5 10 15 att gcc agc aaa gag aga acg tta tcc tct ggg cag gaa caa gtt gtt 95 Ile Ala Ser Lys Glu Arg Thr Leu Ser Ser Gly Gln Glu Gln Val Val 20 25 30 gaa agt gat aca cta aca att gag tct gga cca ctt gct agt gaa gat 143 Glu Ser Asp Thr Leu Thr Ile Glu Ser Gly Pro Leu Ala Ser Glu Asp 35 40 45 aaa cca ctt tcg tgt ggt aca aac tct gga aaa gaa caa gaa ata aat 191 Lys Pro Leu Ser Cys Gly Thr Asn Ser Gly Lys Glu Gln Glu Ile Asn 50 55 60 gag act ctg cct atc aca act gta gct cag agt tca gtt cta ctt cat 239 Glu Thr Leu Pro Ile Thr Thr Val Ala Gln Ser Ser Val Leu Leu His 65 70 75 cct caa gaa gaa gca gcc agg att aga atg tca gca agg cag aaa cag 287 Pro Gln Glu Glu Ala Ala Arg Ile Arg Met Ser Ala Arg Gln Lys Gln 80 85 90 95 ata atg gaa ata gaa gag cag aag caa aag caa ttg gaa tta ctt gaa 335 Ile Met Glu Ile Glu Glu Gln Lys Gln Lys Gln Glu Leu Leu Glu 100 105 110 caa att gaa cag cag aaa tta aga tta gaa act gac tgc ttc agg gct 383 Gln Ile Glu Gln Gln Lys Leu Arg Leu Glu Thr Asp Cys Phe Arg Ala 115 120 125 cag ctg gaa gaa gaa aaa aga aga gag act act gga 431 Gln Leu Glu Glu Glu Lys Arg Lys Lys Thr Gln Pro Thr Gly Val Gly 130 135 140 tgc aga aaa tct cat cac tac ata aat cat ttg gtt ggc att gct cca 479 Cys Arg Lys Ser His His Tyr Ile Asn His Leu Val Gly Ile Ala Pro 145 150 155 gca tca tgc cct gta att tct gat gaa gat agt cat agg cag atg att 527 Ala Ser Cys Pro Val Ile Ser Asp Glu Asp Ser His Arg Gln Met Ile 160 165 170 175 cgt aac tat caa cat cag ctt tta caa caa aac agg tta cac agg cag 575 Arg Asn Tyr Gln His Gln Leu Leu Gln Gln Asn Arg Leu His Arg Gln 180 185 190 tct gtt gaa aca gcc agg aaa caa tta ctt gaa tat caa act atg tta 623 Ser Val Glu Thr Ala Arg Lys Gln Leu Leu Glu Tyr Gln Thr Met Leu 195 200 205 aaa gga agg tgc cca tcg gtg tca gct cca tca ttg ata act gat tct 671 Lys Gly Arg Cys Pro Ser Val Ser Ala Pro Ser Leu Ile Thr Asp Ser 21 0 215 220 gtt ata tca gtg cca tca tgg aaa tct gag aga ccg act gct ata tca 719 Val Ile Ser Val Pro Ser Trp Lys Ser Glu Arg Pro Thr Ala Ile Ser 225 230 235 gag cat tgg gat caa ggt cag aga ctc aag ttg agt cct aac aaa tac 767 Glu His Trp Asp Gln Gly Gln Arg Leu Lys Leu Ser Pro Asn Lys Tyr 240 245 250 255 caa ccc ata caa cct ata cag acc tcc aaa tta gaa caa gat cat ttt 815 Gln Pro Ile Gln Pro Ile Gln Thr Ser Lys Leu Glu Gln Asp His Phe 260 265 270 270 cag gta gcg aga caa aat cac ttt cca caa aga cag gtg gaa aca aca 863 Gln Val Ala Arg Gln Asn His Phe Pro Gln Arg Gln Val Glu Thr Thr 275 280 280 285 gaa aca tta cgc gct tca gat att tta acc aat caa gct tta gaa tca 911 Glu Thr Leu Arg Ala Ser Asp Ile Leu Thr Asn Gln Ala Leu Glu Ser 290 295 300 caa gaa cat cta agg caa ttc tct cag act gaa aca caa cag aga gac 959 Gln Glu His Leu Arg Gln Phe Ser Gln Thr Glu Thr Gln Gln Arg Asp 305 310 315 tat aaa ttg gtc ccc aaa gat tct gag aca ctt tca agg gct ttg tca 1007 Tyr Lys Leu Val Pro Lys Asp Ser Glu Thr Leu Ser Arg A la Leu Ser 320 325 330 335 cat gac agg cag cta ata tca cag gat gct aga aaa ata tct gaa aca 1055 His Asp Arg Gln Leu Ile Ser Gln Asp Ala Arg Lys Ile Ser Glu Thr 340 345 350 350 ttt ggg gca aca act ttt caa agt tta gaa tcc caa caa ttg ttc tca 1103 Phe Gly Ala Thr Thr Phe Gln Ser Leu Glu Ser Gln Gln Leu Phe Ser 355 360 365 gag aat agt gaa aat ata tct tac cat tta act gaa cct tct tca ttt 1151 Glu Asn Ser Glu Asn Ile Ser Tyr His Leu Thr Glu Pro Ser Ser Phe 370 375 380 gta cca ctg gta cct cag cat tct ttt agt tct ctg cct gtt aaa gtt 1199 Val Pro Leu Val Pro Gln His Ser Phe Ser Ser Leu Pro Val Lys Val 385 390 395 gag tca gga aaa att caa gaa ccc ttt tca gcc atg agc aaa agt aca 1247 Glu Ser Gly Lys Ile Gln Glu Pro Phe Ser Ala Met Ser Lys Ser Thr 400 405 410 415 gtt tcc aca agc cat tct ata atc agc caa atg cat gat agg cct ttg 1295 Val Ser Thr Ser His Ser Ile Ile Ser Gln Met His Asp Arg Pro Leu 420 425 430 ctg ccg tca gag aat atc aca gcc cag caa ggt aat atg aag gcc ctc 1343 Leu Pro Ser Glu Asn Ile Thr Al a Gln Gln Gly Asn Met Lys Ala Leu 435 440 445 caa gaa cag tta gac cta cag aag aaa gtt ctt cag gca act cag gaa 1391 Gln Glu Gln Leu Asp Leu Gln Lys Lys Val Leu Gln Ala Thr Gln Glu 450 455 460 gct cag gaa cag ttg ctt ttg tgc aaa cag aaa gaa gtg gaa cag caa 1439 Ala Gln Glu Gln Leu Leu Leu Cys Lys Gln Lys Glu Val Glu Gln Gln 465 470 475 acg ggc ctc tcg gta ttc ctt ccc gtt g 1487 Thr Gly Leu Ser Val Phe Leu Pro Leu Val Thr Pro Asp Ser Ser Ala 480 485 490 495 tta ttg cct tct gcc aaa gca gat ttg ggg aga atc cag gaa tct tca 1535 Leu Leu Pro Ser Ala Lys Ala Asp Leu Gly Arg Ile Gln Glu Ser Ser 500 505 510 cca acc aag aat aat att gca gtt tcc tca gac cat cat gtg atc tca 1583 Pro Thr Lys Asn Asn Ile Ala Val Ser Ser Asp His His Val Ile Ser 515 520 525 caa ctt cag gat aag cgt ttg agt ctt tca cag cct atc cta tca cag 1631 Gln Leu Gln Asp Lys Arg Leu Ser Leu Ser Gln Pro Ile Leu Ser Gln 530 535 540 caa aat aat ttt aaa ttt ctc caa gag cag ttg aat att cag aag gat 1679 Gln Asn Asn Phe Lys Phe Leu Gln Glu Gln Leu Asn Ile Gln Lys Asp 545 550 555 agc ctt cag gct agg cga gaa gcc cag gaa gta ttg tat gta cat aaa 1727 Ser Leu Gln Ala Arg Arg Glu Ala Gln Glu Val Leu Tyr Val His Lys 565 570 575 cag agt gaa ttg gat aga aga gta tgt tcc gaa cag gct gag ccc tct 1775 Gln Ser Glu Leu Asp Arg Arg Val Cys Ser Glu Gln Ala Glu Pro Ser 580 585 590 590 ttc cca ttt cag gta gct cag cat aca ttt act tca cta cca tct gct 1823 Phe Pro Phe Gln Val Ala Gln His Thr Phe Thr Ser Leu Pro Ser Ala 595 600 605 gat aca aaa tct gga aaa ata cag gag caa cat tca tct aag agc gag 1871 Asp Thr Lys Ser Gly Lys Ile Gln Glu Gln His Ser Ser Lys Ser Glu 610 615 620 aaa gga ctt gtt tca tgc caa tct gac atc ccc ata tct cag gat ggg 1919 Lys Gly Leu Val Ser Cys Gln Ser Asp Ile Pro Ile Ser Gln Asp Gly 625 630 635 635 tct ttg agt ttc cta cag cag ttc cta cct cta cat gat agt ttg aag 1967 Ser Leu Ser Phe Leu Gln Gln Phe Leu Pro Leu His Asp Ser Leu Lys 640 645 650 655 ttg ctc caa gaa cag ttg act aaa cag agg gat act ctt cag gct agg 2015 Leu Leu Gln Glu Gln Leu Thr Lys Gln Arg Asp Thr Leu Gln Ala Arg 660 665 670 cat gaa gct cag gtg gaa tta ctt tta cat aga caa aga gat ttg ggg 2063 His Glu Ala Gln Val Glu Leu Leu Leu His Arg Gln Arg Asp Leu Gly 675 680 685 gac agt aag tct ggg ctg gtg agc tct tca tcc tca cca gtg gtt gtt 2111 Asp Ser Lys Ser Gly Leu Val Ser Ser Ser Ser Ser Pro Val Val Val 690 695 700 cag cat tca gtt gct tca caa gct tct gct aaa gct gag cct agg aga 2159 Gln His Ser Val Ala Ser Gln Ala Ser Ala Lys Ala Glu Pro Arg Arg 705 710 715 att cag gag ctt tat tta tct gag aag gag aat gta ggt ccc tcc tgt 2207 Ile Gln Glu Leu Tyr Leu Ser Glu Lys Glu Asn Val Gly Pro Ser Cys 720 725 730 735 cat ttg ata atc cca aca ttt cag gat aag tct ctt agt ttt cca cag 2255 His Leu Ile Ile Pro Thr Phe Gln Asp Lys Ser Leu Ser Phe Pro Gln 740 745 750 cat agc ctg gca cag caa gaa aat ttg aca ata ctc caa gaa cag tca 2303 His Ser Leu Ala Gln Gln Glu Asn Leu Thr Ile Leu Gln Glu Gln Ser 755 760 765 caa ata caa agg gta ata ctt ggt act aa gaa gga act cag gaa ttt 2351 Gln Ile Gln Arg Val Ile Leu Gly Ala Lys Glu Gly Thr Gln Glu Phe 770 775 780 gta cac aca gaa agt gaa ttg gag aaa aga att tct tct gaa cag act 2399 Val His Thr Glu Ser Glu Leu Glu Lys Arg Ile Ser Ser Glu Gln Thr 785 790 795 ggc acc tcc tca tcc ctt tcc cag gtg gat gaa tct gag aga ttc cag 2447 Gly Thr Ser Ser Ser Leu Ser Gln Val Asp Glu Ser Glu Arg Phe Gln 800 805 810 810 815 815 gaa tgt ata tca atc aag agt gac agt acc att ccc tta agc cat cct 2495 Glu Cys Ile Ser Ile Lys Ser Asp Ser Thr Ile Pro Leu Ser His Pro 820 825 830 aag atc cca aga tgt cag gaa aga ctt ttg aga gtt tca caa cat atg 2543 Lys Ile Pro Arg Cys Gln Glu Arg Leu Leu Arg Val Ser Gln His Met 835 840 845 cta cct cta caa gat aat ttg gag gaa cac caa gca tgg cta gac act 2591 Leu Pro Leu Gln Asp Asn Leu Glu Glu His Gln Ala Trp Leu Asp Thr 850 855 860 gag aaa gaa gcc ttt cat ttc agc cag aaa acc caa gaa aat aca tct 2639 Glu Lys Glu Ala Phe His Phe Ser Gln Lys Thr Gln Glu Asn Thr Ser 865 870 870 875 tct gaa caa act gg t tca tct tca ttc ata ccc cag ttg gta cag ctt 2687 Ser Glu Gln Thr Gly Ser Ser Ser Phe Ile Pro Gln Leu Val Gln Leu 880 885 890 895 tca ttt act tcg tta gct tca gct gag tct ggc aca atc ctg gaa cct 2735 Ser Phe Thr Ser Leu Ala Ser Ala Glu Ser Gly Thr Ile Leu Glu Pro 900 905 910 ctt ttt aca gag agt gaa agt aaa att ttt tca agc cac ctt cag atc 2783 Leu Phe Thr Glu Ser Glu Ser Lys Ile Phe Ser Ser His Leu Gln Ile 915 920 925 cca caa ttg cag gat agg ctt ttg agg ata tcg caa ctt atc cag cct 2831 Pro Gln Leu Gln Asp Arg Leu Leu Arg Ile Ser Gln Leu Ile Gln Pro 930 935 940 caa caa gat aat cttg aag gca gaa cag tta gct aca cag aga 2879 Gln Gln Asp Asn Leu Lys Ala Leu Gln Glu Gln Leu Ala Thr Gln Arg 945 950 955 gaa gcc atc att cta gct aga caa gaa gct cgg gaa gaa tta ctt tta 2927 Ile Ala Ala Arg Gln Glu Ala Arg Glu Glu Leu Leu Leu 960 965 970 975 cat cag agt gaa tgg gag gga aga ata tct ccc gag cag gtt gac acc 2975 His Gln Ser Glu Trp Glu Gly Arg Ile Ser Pro Glu Gln Val Asp Thr 980 985 990 tct tcc tta ccc cta gta cca cag cat tca ttc gcc tca tta cct ctt 3023 Ser Ser Leu Pro Leu Val Pro Gln His Ser Phe Ala Ser Leu Pro Leu 995 1000 1005 aat gaa tct gaa aga aac caa gaa cca tgt tca att aac agt gat aat 3071 Asn Glu Ser Glu Arg Asn Gln Glu Pro Cys Ser Ile Asn Ser Asp Asn 1010 1015 1020 ata gta tcc tca ggt cac tca gag ata cca aca ttg cct gat ggg ctg 3119 Ile Val Ser Ser Gly His Ser Glu Ile Pro Thr Leu Pro Asp Gly Leu 1025 1030 1035 ttg ggt tta tca cat ctt gtt tta cct caa caa gat aat ttg att gca 3167 Leu Gly Leu Ser His Leu Val Leu Pro Gln Gln Asp Asn Leu Ile Ala 1040 1045 1050 1055 ctt gaa gaaac ttg cat gca cag aca gat ttc ctt cct tct att gag 3215 Leu Glu Glu His Leu His Ala Gln Thr Asp Phe Leu Pro Ser Ile Glu 1060 1065 1070 aaa acc cag aaa gaa ttg gtt ttg tca aaa cca tgt aaa ttt gag gaa 3263 Thr Gln Lys Glu Leu Val Leu Ser Lys Pro Cys Lys Phe Glu Glu 1075 1080 1085 aag gta tct tct gag cat ttt atc cag tct cac cat ggt gat ttg cag 3311 Lys Val Ser Ser Glu His Phe Ile G ln Ser His His Gly Asp Leu Gln 1090 1095 1100 gca ctt caa cag cag tta gat aca cag aag aaa gcc att cga tct ata 3359 Ala Leu Gln Gln Gln Leu Asp Thr Gln Lys Lys Ala Ile Arg Ser Ile 1105 1110 1115 cag gaa gtc caa gaa gaa ttg ctt ttg caa aga tta agt gaa ttg gag 3407 Gln Glu Val Gln Glu Glu Leu Leu Leu Gln Arg Leu Ser Glu Leu Glu 1120 1125 1130 1135 aaa agg gta tca tct gaa caa gtt tgc tcc tct tca tcc 3455 Lys Arg Val Ser Ser Glu Gln Val Cys Ser Ser Ser Phe Val Ser Gln 1140 1145 1150 gtg cct gtt gct gac tct gaa aga acc cag aag tct ttc cca acc aaa 3503 Val Pro Val Ala Asp Ser Glu Arg Thr Gln Lys Ser Phe Pro Thr Lys 1155 1160 1165 agt aat gat act ctt ccc tca agt cat cgt gag att cca aga tta cag 3551 Ser Asn Asp Thr Leu Pro Ser Ser His Arg Glu Ile Pro Arg Leu Gln 1170 1175 1180 gat aga ctt ttg agt tta tca aag cct att ctg cct cag caa gat aat 3599 Asp Arg Leu Leu Ser Leu Ser Lys Pro Ile Leu Pro Gln Gln Asp Asn 1185 1190 1195 atg aca gca caa ttg gat gca caa agg gaa gtg atg tat tct tat g ag 3647 Met Thr Ala Gln Leu Asp Ala Gln Arg Glu Val Met Tyr Ser Tyr Glu 1200 1205 1210 1215 aaa ccc cag gaa gaa ctg tct tta aac aaa caa aga aag ttg aac aaa 3695 Lys Pro Gln Glu Glu Glu Leu Ser Leu Asn Lys Gn Arg Lys Leu Asn Lys 1220 1225 1230 agt gaa tct gct gag cat act atc ccc tct ttg ttt cta ccc aag gaa 3743 Ser Glu Ser Ala Glu His Thr Ile Pro Ser Leu Phe Leu Pro Lys Glu 1235 1240 1245 aca gag cat tcg ttt att cca cta cct ttt gca gaa gct aaa cct aaa 3791 Thr Glu His Ser Phe Ile Pro Leu Pro Phe Ala Glu Ala Lys Pro Lys 1250 1255 1260 agc act tgt gaa ttg tat tca tcc cag aat gaa cat gca gcc ccc cca 3839 Ser Thr Cys Glu Leu Tyr Ser Ser Gln Asn Glu His Ala Ala Pro Pro 1265 1270 1275 agt aat cct gtg atc cca ggg ttt caa gat aga ctt ttg agt ttt tca 3887 Ser Asn Pro Val Ile Pro Gly Phe Gln Asp Arg Leu Leu Ser Phe Ser 1280 1285 1290 1295 cag tct gtc tta act cag caa gat aac ttg gga ctt cag aaa cag ttg 3935 Gln Ser Val Leu Thr Gln Gln Asp Asn Leu Gly Leu Gln Lys Gln Leu 1300 1305 1310 gat cta caa aga gaa gtt ctg cat tat agc cag aaa gcc cag gaa aaa 3983 Asp Leu Gln Arg Glu Val Leu His Tyr Ser Gln Lys Ala Gln Glu Lys 1315 1320 1325 ttg ctt gta cag aga caa aca gca ttg cag cag cag ata Cag aaa cat 40 Leu Val Gln Arg Gln Thr Ala Leu Gln Gln Gln Ile Gln Lys His 1330 1335 1340 gaa gag act ttg aag gat ttc ttt aaa gac agt cag ata agt aag ccc 4079 Glu Glu Thr Leu Lys Asp Phe Phe Lys Asp Ser Gln Ile Ser Lys Pro 1345 1350 1355 aca gtt gaa aat gat tta aaa acc cag aag atg ggg cag ctc aga gac 4127 Thr Val Glu Asn Asp Leu Lys Thr Gln Lys Met Gly Gln Leu Arg Asp 1360 1365 1370 1370 1375 tgg ttt cct aat aca caa gac cta gca gga aat gat caa gaa aat att 4175 Trp Phe Pro Asn Thr Gln Asp Leu Ala Gly Asn Asp Gln Glu Asn Ile 1380 1385 1390 agg cat gca gat agg aac aac tct gat gat aat cat ttg gct tca gaa 4223 Arg His Ala Asp Arg As Asn Ser Asp Asp Asn His Leu Ala Ser Glu 1395 1400 1405 gat act agt gcc aag caa agt ggt gag cat ctg gag aaa gat ctg ggg 4271 Asp Thr Ser Ala Lys Gln Ser Gly Glu His Leu Glu Lys Asp Leu Gly 1410 1415 1420 aga aga tcc tca aag cca cct gta gca aaa gtc aaa tgt ggt ttg gac 4319 Arg Arg Ser Ser Lys Pro Pro Val Ala Lys Val Lys Cys Gly Leu Asp 1425 1430 1435 tta aac cag cat gaa ctt agt gct ata caa gaa gta gag tca cca gca 4367 Leu Asn Gln His Glu Leu Ser Ala Ile Gln Glu Val Glu Ser Pro Ala 1440 1445 1450 1455 att ggc aga act tct ata cta ggt aaa cca ggt att tat gaa gac aga 4415 Ile Gly Arg Thr Ser Ile Leu Gly Lys Pro Gly Ile Tyr Glu Asp Arg 1460 1465 1470 gac ccc ctg cga gtc tca ata agc cga gaa caa agt ttc ttt ggg agc 4463 Asp Pro Leu Arg Val Ser Ile Ser Arg Glu Gln Ser Phe Phe Gly Ser 1475 1485 cca ctg gcc cat gat ccg ttt agt tgt ctt caa ctg gtt ggc caa gag 4511 Pro Leu Ala His Asp Pro Phe Ser Cys Leu Gln Leu Val Gly Gln Glu 1490 1495 1500 aat gtc tgt ggt gat gac tat gat gaa gca ggt gag taaatggaaa 4560 Asn Val Cys Gly Asp Asp Tyr Asp Glu Ala Gly Glu Lys 1505 1510 1515 gtggaattgt atgcacaagg atatgtggac aaaagatatt tattattttg ttatttgtaa 4620 tggtgaaaaa acttagttac tgctgttaat ggaatcgtta tgatgcagtt 4680 aactatattg ttctatgcag ttgttaaatg agtaattttg cttttaaatt gttttattaa 4740 atgccagtaa gaagtttatc aaggtaggag ttttatacaa ttggcagcat ccataaattt 4800 tatgtttaag cctatttgta acaatccata tctaattaaa tactgttaaa tattttaaaa 4860 attctatctg tgggcattct aaataagctg ttttatgttt atttttaaat atttggaaaa 4920 ataaagataa ttagaaggaa aaatatttaa atcacttaat cctaacaccc aaagacagcc 4980 aatgttaatc ttctcgcttc tgaatttata tatgtatata tatatagcac aggatatttt 5040 atatataatt tgtgtactga tcctacaaag tatagttgta gtactatttt attagttgta 5100 aggcatcttt taagaagtta cattttggcc gggtgcagtg gctcacgtct gtgatcctag 5160 cactttggga ggccaagact ggcagatcat gaggtcagaa gattgagacc acggctaaca 5220 ccgtgaaacc ctgtctatac taaaagtaca aaaaattggc cgggtgtagt ggtggtcacc 5280 tgtagtcctg tagggaggca ggagaatggc gtgaacctgg gaggtggagc ttgcagtgag 5340 ccgagatcaa gccactgcac tccagcctgg gcgacagagc gagactccga gactccatct 5400 g 5401 <210> 211 <211> 4784 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (55) .. (1581) <400> 211 tatttagcaa gatcaaagac actctggctg gaacggctct tgttttaccg ctga cag 57 Gln 1 ata gcc ttt gat ttt tat ttt ttg cag tgt tcc agt gtt ttc tct caa 105 Ile Ala Phe Asp Phe Tyr Phe Leu Gln Cys Ser Sern aac tct gtg ttt gga aca tca agg atg gat tat ccc aaa atg gat tat 153 Asn Ser Val Phe Gly Thr Ser Arg Met Asp Tyr Pro Lys Met Asp Tyr 20 25 30 ttt ctg gat gta gag tct gct cac aga ctc ttg gat gtt gag tca gct 201 Phe Leu Asp Val Glu Ser Ala His Arg Leu Leu Asp Val Glu Ser Ala 35 40 45 caa aga ttc ttc tac agt caa gga gct caa gct cgc cgg gcg acc ctg 249 Gln Arg Phe Phe Tyr Ser Gln Gly Ala Gln Ala Arg Arg Ala Thr Leu 50 55 60 65 ctc ctg cct ccc aca tta atg gcg gca tcc tcg gag gat gat ata gac 297 Leu Leu Pro Pro Thr Leu Met Ala Ala Ser Ser Glu Asp Asp Ile Asp 70 75 80 cgg cgg ccc atc cgg aga gtg cgc tcc aag agc gac acg ccg tac ctc 345 Arg Arg Pro Ile Arg Arg Val Arg Ser Lys Ser Asp Thr Pro Tyr Leu 85 90 95 gca gag gcc agg atc tcc ttt aac ctg ggg gca gct gag gaa gtg gag 393 Ala Glu Ala Arg Ile Ser Phe Asn Leu Gly Ala Ala Glu Glu Val Glu 100 105 110 agg ctg gcg gcg atg cgt tct gac tcc ctc gtc cca ggc acc cac acc 441 Arg Leu Ala Ala Met Arg Ser Asp Ser Leu Val Pro Gly Thr His Thr 115 120 125 cca ccc atc cgc agg aga agt aag ttt gcc aac ctg gga agg att ttc 489 Pro Pro Ile Arg Arg Arg Ser Lys Phe Ala Asn Leu Gly Arg Ile Phe 130 135 140 145 aag cct tgg aaa tgg agg aag aag aag aaa agc gaa aag ttc aaa cac acg 537 Lys Pro Trp Lys Trp Arg Lys Lys Lys Ser Glu Lys Phe Lys His Thr 150 155 160 tca gca gcc ctg gaa agg aaa ata tct atg agg caa agc aga gaa gag 585 Ser Ala Ala Le Arg Lys Ile Ser Met Arg Gln Ser Arg Glu Glu 165 170 175 ctg ata aag cga gga gtc ctg aag gaa atc tat gat aaa gat ggg gaa 633 Leu Ile Lys Arg Gly Val Leu Lys Glu Ile Tyr Asp Lys Asp Gly Glu 180 ctc tct ata tcc aat gaa gag gac tcc cta gaa aat ggg cag tcc ctg 681 Leu Ser Ile Ser Asn Glu Glu Asp Ser Leu Glu Asn Gly Gln Ser Leu 195 200 205 agc tcc agc cag ctg tct ctg cct gcc ctg gcccca gtc 729 Ser Ser Ser Gln Leu Ser Leu Pro Ala Leu Ser Glu Met Glu Pro Val 210 215 220 225 cca atg ccc agg gat ccc tgc tca tat gag gtg ctc caa ccg tca gac 777 Pro Met Pro Arg Asp Pro Cys Ser Tyr Glu Val Leu Gln Pro Ser Asp 230 235 240 atc atg gat ggg cca gat cct ggc gcc cct gtg aaa ttg cct tgt ctg 825 Ile Met Asp Gly Pro Asp Pro Gly Ala Pro Val Lys Leu Pro Cys Leu 245 250 255 cca gtg aaa ctg tcg cct ccg cta cct cca aag aaa gtc atg atc tgt 873 Pro Val Lys Leu Ser Pro Pro Leu Pro Pro Lys Lys Val Met Ile Cys 260 265 270 atg ccc gtg ggg ggg cca gac ctc tca ctg gtg tcc tac aca gcc cag 921 Met Pro Val Gly Gly Pro Asp Leu Ser Leu Val Ser Tyr Thr Ala Gln 275 280 285 aag agt ggc cag cag ggt gtg gcc cag cac cac cac act gtc ctg ccc 969 Lys Ser Gly Gln Gln Gly Val Ala Gln His His His Thr Val Leu Pro 290 295 300 305 tcc cag atc cag cac cag ctg cag tac ggc agc cac ggc cag cac ctc 1017 Ser Gln Ile Gln His Gln Leu Gln Tyr Gly Ser His Gly Gln His Leu 310 315 320 ccc tcc acc acc ggc tcc ctc ccc atgcac ccc tcg ggc tgc aga atg 1065 Pro Ser Thr Thr Gly Ser Leu Pro Met His Pro Ser Gly Cys Arg Met 325 330 335 ata gac gag ctc aac aaa acg ctg gcc atg acc atg cag agg ctg gaa 1113 Ile Asp Glu Leu Asn Lys Thr Leu Ala Met Thr Met Gln Arg Leu Glu 340 345 350 agc tct gag cag cgg gtc ccc tgt tcc act tct tac cac agc tct ggg 1161 Ser Ser Glu Gln Arg Val Pro Cys Ser Thr Ser Tyr His Ser Ser Gly 355 360 365 ttg cac tcg ggt gat ggg gtc acc aaa gca gga cct atg ggc ctt cca 1209 Leu His Ser Gly Asp Gly Val Thr Lys Ala Gly Pro Met Gly Leu Pro 370 375 380 385 gaa ata aga caa gtg cca act gtt gtg att gaa tgt gat ag aaa 1257 Glu Ile Arg Gln Val Pro Thr Val Val Ile Glu Cys Asp Asp Asn Lys 390 395 400 gaa aat gtg cct cat gag tca gac tac gaa gac tct tct tgc ctg tat 1305 Glu Asn Val Pro His Glu Ser Asp Tyr Glu Asp Ser Ser Cys Leu Tyr 405 410 415 aca aga gaa gag gag gaa gag gag gag gac gaa gac gac gac agc tca 1353 Thr Arg Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Serp Ser Ser 420 425 430 430 tta tac acc agc tcc ctg gcc atg aag gtc tgc agg aag gac tcc tta 1401 Leu Tyr Thr Ser Ser Leu Ala Met Lys Val Cys Arg Lys Asp Ser Leu 435 440 445 gcc att aaa ctc agc aac agg ccc tcc aag cga gag ctg gaa gaaaag 1 Lys Leu Ser Asn Arg Pro Ser Lys Arg Glu Leu Glu Glu Lys 450 455 460 465 aac atc ctt ccc agg cag acg gat gag gag cgg ctg gag ctg agg caa 1497 Asn Ile Leu Pro Arg Gln Thr Asp Glu Glu Arg Leu Glu Leu Arg Gln 470 475 480 cag att ggc acc aag ctc acc agg cgg ctg agc cag agg cca act gca 1545 Gln Ile Gly Thr Lys Leu Thr Arg Arg Leu Ser Gln Arg Pro Thr Ala 485 490 495 gag gaa ctg gaa cag agg aac atttt cgt aag tgactaagcc 1591 Glu Glu Leu Glu Gln Arg Asn Ile Leu Lys Arg Lys 500 505 catggcaatc cctgatgttt tgtggcggct tttgttatta tttaatggta ggccacaagg 1651 tttctacctt gcgcctctgc ggaaagcatt gaaaaccttt ctaacggttg aagcttcatg 1711 tgtgcatgtt agaacaccaa agacgacctc cccaaggaga aggcaaattt tattccactt 1771 tattctttag aagctcacgg gcggcaggca gaaccttcct tttagtgagt tgtaaagtca 1831 gagagaagct gaaaaattag agtgagacc a cttattattt aatgattttt aagagcaggg 1891 tcacctttaa accagaattg gcttgaaaat ggagactgtg atatgcacgg ctaaaataag 1951 ggaaatgtcc atttgaactg agactagaaa gcatgacttt gcattgcagc tggctgctgt 2011 tgataaaaat ccctcatccc tttgaatgtt aaattgaaag actaagaaag catttccaag 2071 cgaagtgctt catgtctgtc tctcaggatt cccacagctg gtcccgggca tgcctgtctg 2131 atgctctcat tcgaggaaaa ctgcctttca ccattgctgc agacagaaaa aaataaatga 2191 gccccttgtt tggtttagga cacagagaca tttgaatatg tacagaggat ccacttggtg 2251 ctttaaaaaa aaaaagagaa aacaggatac aaaatactaa aagagatcaa gcatttgatg 2311 gacagcagta tgtgtcagtt tagtggtaga tattaaataa cttaaatatc aaaccattct 2371 attcattcat tgctaccatt ctcgccaaca ctggcctcaa gatagtgaac aaatatttct 2431 ggcttaattc atgaccctgt tccccctacc ccacaacaca cttctaattt ctctccagaa 2491 gagaaagata tatactatgc agagttttct agaaatgcta tgttgtacag actgactcct 2551 cgcctccccc ggccaccccg ccccgccccg ccccgtgccc agtaaatcac atgcaaccgc 2611 agtgtgagtt tgccgggaat ttccactgaa accacactaa gatattcttg actttacctt 2671 tctaccgtgc tcactgtggc cttgtgactt ggtc ggcatt tcgtagtctg ctgaaggtgg 2731 gtgctgggtt ccgctttggt ggggagacct gttgcctaca gcacccaccc ccgcccgacg 2791 cccccgcatg tccgtttatg tcaactctgc ctttatcaat gtcttgcctc ccgtccccac 2851 gccagccgcc acttcctcaa ctctcagtag aagttatttt caggattagc cttcctcagt 2911 cgtgggggaa ccctacgcat tgcctaggtc tctaggaatg tgtgtttact tttttctgcc 2971 caaggggtac cctttaaagt ttccaagctt aatattctat ataatgaatt cagagctttt 3031 tcaaagcatt tccaaggtca gggaagcatt tggcttgtag gatgtcttcc tttcggcccc 3091 aatctggtac ctgagccatt ataaacttcc cattgttgga gagaaagata aacagccagg 3151 tgaacctgta caacttactc acagcccgct gctgtacttg tggcctctga cctgagacct 3211 aaactcaaag aagctaaaag cctccggggg attatttagg tttcagaaaa tagtgcttat 3271 cacaccagga gtacggtttc tggagagatc taaaatcccc tagctcagct ctgggctctc 3331 tcaaagatat cagatccccg ctgtggcttg tccagatccc tgggagacta caggtccttt 3391 gagcttgggt ttttaccgcc atcaaccagg gaacttagat tcaggggacc aaaaaggagt 3451 tgtgaaagat tgttcccatg gttctctttt attctcttcc ctaatccctc ttgtcctggc 3511 cacatagttg caaattaaag aactacttga ccaattcta a caggttggtc atttcatagt 3571 tttgaaactt ttcagaaatc aacttgtttt cccataggtt cttatttttc cctgtattct 3631 ggaactatgt tctcctaaat atttttttaa atttaatcta ttgcgattgt taaacaaaaa 3691 aaatgtctag tggtataaga aaacatcctc caatagtttg ttttaaaact gattttctga 3751 gctttcagcc atttgaggaa ctgctcggtg ttgggtggtg gggaacaggg cacagagatg 3811 ccatggctca gccctggagc tttgagagcc ttgggttggt ttccagcccc accctgcctg 3871 gtcctgggag cagcccctgt tctgtccagc agccagtgag gccctgtgca cctctgagca 3931 cataatgaac cctctgatgg tggcagctgt aatgacgaca tcgtaggcct ttcctggcct 3991 gtcttcccag ttgcctaatg gggttgtctt ggtaccttct gcctgaaaat tcatgaacct 4051 gggttggtca atggctttga actaaaggta tcaattctgt aggtggtagc ttgtggcccc 4111 acccctcaga gtgacctaag aaacgcacat aggagatgaa ggctccatgc tgtgtcagct 4171 gtgtcacagg atgcccgcct tcacggctct gaagggacct gtaggatcag aagtctgagg 4231 ctagtaatga ggaggagagc cggccccaca caaaacatga ccacaggaaa aaacctatct 4291 gtgtaaccac tgagccaggt agggtgtgac tggccactta acacccctga gccttcagat 4351 cctcagttat aaaccaggag tggtagatga ggtggtcact aggt cccctc atggccctag 4411 tattctgtgc ttctgtaaat tttcaccgtg tgccctctag ctgtccctgg tgacccaaca 4471 tccagaccac cttttcttcc atccgttttc ccacctgaga catcgcaaaa tgggagttcc 4531 ctccttctgg ttcttgctgt ctgcctcccc atttaactct gctagattaa ttcatactaa 4591 gatattaatg gctgactagt ttaataggtt ttatcccact gaaatttgca tttgtacaaa 4651 tgtcactgtc tgggggctcc ctacttccgg gtgttgctgt ctgcccccca gtttatctct 4711 actagattaa ttcatactga gctattaatg gctgactagt ttaatgggct tttattcaag 4771 agaaatttgc att 4784 <210> 212 <211> 5073 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3941) <400> 212 cg cct ccc cgc gcc tcg ttc gcc gcc gct gtc gcc gcc gcc gcc cga 47 Pro Pro Arg Ala Ser Phe Ala Ala Ala Val Ala Ala Ala Ala Arg 1 5 10 15 gac tcg cgc aga gca gtt atg gcg gat ccc gca gcc ccc acg ccc gca 95 Asp Ser Arg Arg Ala Val Met Ala Asp Pro Ala Ala Pro Thr Pro Ala 20 25 30 gct ccc gct cca gcc cag gcc ccg gct cca gcc ccg gag gca gtc ccg 143 Ala Pro Ala Pro Ala Gln Ala Pro Ala Pro Ala Pro Glu Ala Val Pro 35 40 45 gcc cca gcc gca gcc ccc gtc ccg gcg ccg gcg ccc gcc tcg gac tcg 191 Ala Pro Ala Ala Ala Ala Pro Val Pro Ala Pro Ala Pro Ala Ser Asp Ser 50 55 60 gcc tcc ggg ccg tcc tcg gac ttc ggc cca gaa gcc ggc tcg cag cgc 239 Ala Ser Gly Pro Ser Ser Asp Phe Gly Pro Glu Ala Gly Ser Gln Arg 65 70 75 ctg ctg ttt tct cac gac ctg gtg tcg ggc cgt tc c 287 Leu Leu Phe Ser His Asp Leu Val Ser Gly Arg Tyr Arg Gly Ser Val 80 85 90 95 cac ttc ggg ctg gtg cgc ctc atc cac ggc gag gac tcg gac tcg gag 335 His Phe Gly Leu Val Arg Leu Ile His Gly Glu Asp Ser Asp Ser Glu 100 105 110 gg c gag gag gag ggc cgc ggg agc tcg ggg tgc tcc gag gcc ggg ggc 383 Gly Glu Glu Glu Gly Arg Gly Ser Ser Gly Cys Ser Glu Ala Gly Gly 115 120 125 gcg ggc cac gag gag ggc cgg gcc agc cccg tac gtg 431 Ala Gly His Glu Glu Gly Arg Ala Ser Pro Leu Arg Arg Gly Tyr Val 130 135 140 cgc gtc cag tgg tac ccg gag ggc gtc aag cag cat gtg aag gag acc 479 Arg Val Gln Trp Tyr Pro Glu Gly Val Lys Gln His Val Lys Glu Thr 145 150 155 aag ctg aaa cta gag gac cgt tct gtg gtg ccc cga gat gtg gtc cgg 527 Lys Leu Lys Leu Glu Asp Arg Ser Val Val Pro Arg Asp Val Val Arg 160 165 170 175 cac atg cga tcc acc gac agt cag tgt ggc acg gtg atc gac gtc aac 575 His Met Arg Ser Thr Asp Ser Gln Cys Gly Thr Val Ile Asp Val Asn 180 185 190 atc gac tgt gcc gtc aag ctc atc ggc acc aac tgc atc atc tat ccc 623 Ile Asp Cys Ala Val Lys Leu Ile Gly Thr Asn Cys Ile Ile Tyr Pro 195 200 205 gtc aac agc aag gac ctg cag cac atc tgg ccc ttc atg tat ggg gac 671 Val Asn Ser Lys Asp Leu Gln His Ile Trp Pro Phe Met Tyr Gly Asp twenty one 0 215 220 tac att gcc tat gac tgc tgg ctg ggg aag gtc tac gac ttg aag aac 719 Tyr Ile Ala Tyr Asp Cys Trp Leu Gly Lys Val Tyr Asp Leu Lys Asn 225 230 235 cag atc atc ctg aag cta tcc aacgg tgc tcc atg aac acg 767 Gln Ile Ile Leu Lys Leu Ser Asn Gly Ala Arg Cys Ser Met Asn Thr 240 245 250 255 gaa gat ggc gcc aag ctc tac gac gtc tgc ccg cac gtc agc gac tcg 815 Glu Asp Gly Asp Val Cys Pro His Val Ser Asp Ser 260 265 270 ggt ctc ttc ttc gat gat tcc tat ggc ttc tac cca ggc cag gtg ctc 863 Gly Leu Phe Phe Asp Asp Ser Tyr Gly Phe Tyr Pro Gly Gln Val Leu 275 280c 285 att cct gcc aag atc ttc tcc agc gtc cag tgg ctg tca ggt gtc 911 Ile Gly Pro Ala Lys Ile Phe Ser Ser Val Gln Trp Leu Ser Gly Val 290 295 300 aag ccc gtg ctc agc acc aag agc aag ttc g ag g g g 959 Lys Pro Val Leu Ser Thr Lys Ser Lys Phe Arg Val Val Val Glu Glu 305 310 315 gtg cag gtt gta gag ttg aaa gtt aca tgg att acc aag agt ttc tgt 1007 Val Gln Val Val Glu Leu Lys Val Thr Trp Ile Thr Lys S er Phe Cys 320 325 330 335 cca ggg ggc acg gac agc gtc agc ccc cca ccc tct gtc atc acc cag 1055 Pro Gly Gly Thr Asp Ser Val Ser Pro Pro Pro Ser Val Ile Thr Gln 340 345 350 gaa aac cta ggc agg gtg aag cgt ctc gga tgc ttt gac cat gct cag 1103 Glu Asn Leu Gly Arg Val Lys Arg Leu Gly Cys Phe Asp His Ala Gln 355 360 365 cgg cag ctt ggg gag cgc tgt ctg tat gtc ttc cca gcc aag gta gag Leu1 Arg Gln Glu Arg Cys Leu Tyr Val Phe Pro Ala Lys Val Glu 370 375 380 cca gcc aag att gcc tgg gaa tgt cca gaa aaa aac tgc gcc cag ggg 1199 Pro Ala Lys Ile Ala Trp Glu Cys Pro Glu Lys Asn Cys Ala Gln Gly 385 395 gag ggc tct atg gcc aag aag gtg aag cgc ctg ttg aag aag cag gtt 1247 Glu Gly Ser Met Ala Lys Lys Val Lys Arg Leu Leu Lys Lys Gln Val 400 405 410 415 gtg cgg atc atg tca tgc tcc cca gac ca tcc cgg gac cat 1295 Val Arg Ile Met Ser Cys Ser Pro Asp Thr Gln Cys Ser Arg Asp His 420 425 430 tcc atg gaa gac cca gac aag aag ggg gaa tcc aaa acc aag agc gaa 1343 Ser Met Glu Asp Pro Asp Lys Ly s Gly Glu Ser Lys Thr Lys Ser Glu 435 440 445 gcg gag tct gcc agc cct gag gag acg ccc gat ggc tct gcc agt cca 1391 Ala Glu Ser Ala Ser Pro Glu Glu Thr Pro Asp Gly Ser Ala Ser Pro 450 455 460 gtg gag atg cag gac gag ggt gca gag gag ccc cac gag gca gga gag 1439 Val Glu Met Gln Asp Glu Gly Ala Glu Glu Pro His Glu Ala Gly Glu 465 470 475 cag ctg ccc cca ttc ctg cta aaa gaa ggc aga gat cac 1487 Gln Leu Pro Pro Phe Leu Leu Lys Glu Gly Arg Asp Asp Arg Leu His 480 485 490 495 tcg gca gag cag gac gca gat gat gag gct gct gat gac acg gac gac 1535 Ser Ala Glu Gln Asp Ala Asp Asp Glu Ala Ala Asp Asp Thr Asp Asp 500 505 510 acc agt tcg gtg acc tcc tct gcc agc tcc acc act tcc tcc cag agc 1583 Thr Ser Ser Val Thr Ser Ser Ala Ser Ser Thr Thr Ser Ser Gln Ser 515 520 525 ggc agc ggc acg agt cgc aaa aag agc atc ccc ttg tcc atc aag aac 1631 Gly Ser Gly Thr Ser Arg Lys Lys Ser Ile Pro Leu Ser Ile Lys Asn 530 535 540 tta aag cgc aaa cac aag agg aag aag aat aaa atc act cga gac ttc 1679 Leu Lys Ar g Lys His Lys Arg Lys Lys Asn Lys Ile Thr Arg Asp Phe 545 550 555 aag cca ggg gac agg gtg gca gtg gag gtg gtg acc acg atg acc tca 1727 Lys Pro Gly Asp Arg Val Ala Val Glu Val Val Thr Thr Met Thr Ser 560 565 570 575 gcc gac gtg atg tgg cag gat ggc tcc gtg gaa tgc aac atc cgc tcc 1775 Ala Asp Val Met Trp Gln Asp Gly Ser Val Glu Cys Asn Ile Arg Ser 580 585 590 aac gac ctc ttc cct gc gc aac aac gag ttc tgc cct 1823 Asn Asp Leu Phe Pro Val His His Leu Asp Asn Asn Glu Phe Cys Pro 595 600 605 gga gac ttc gtg gta gat aag cga gtc cag agc tgt cca gac cct gct 1871 Gly Asp Phe Val Asp Lys Arg Val Gln Ser Cys Pro Asp Pro Ala 610 615 620 gtc tac ggt gtg gta cag tct ggg gac cac atc ggc cgt acc tgc atg 1919 Val Tyr Gly Val Val Gln Ser Gly Asp His Ile Gly Arg Thr Cys Met 625 630 630 635 gtg aag tgg ttc aag ctg agg ccg agt ggg gac gac gtg gag ctg att 1967 Val Lys Trp Phe Lys Leu Arg Pro Ser Gly Asp Asp Val Glu Leu Ile 640 645 650 655 gga gaa gag gaa gat gtg agt gtt tac gac att gct cct gac 2015 Gly Glu Glu Glu Asp Val Ser Val Tyr Asp Ile Ala Asp His Pro Asp 660 665 670 ttt agg ttc cgt aca act gac atc gtc atc cgc atc ggc aat act gag 2063 Phe Arg Phe Arg Thr Thr Asp Ile Val Ile Arg Ile Gly Asn Thr Glu 675 680 685 gat ggg gct cct cac aag gag gat gag cca tcg gtg ggc cag gtg gcc 2111 Asp Gly Ala Pro His Lys Glu Asp Glu Pro Ser Val Gly Gln Val Ala 690 695 700 cgt gtg gac gc agc ag aag gtg gag gtg gtg tgg gct gac aac tca 2159 Arg Val Asp Val Ser Ser Lys Val Glu Val Val Trp Ala Asp Asn Ser 705 710 715 aag acc atc atc ctg ccc cag cac ttg tac aac ata gag tct gag att 2207 Lys Thr Ile Ile Leu Pro Gln His Leu Tyr Asn Ile Glu Ser Glu Ile 720 725 730 735 gag gag tca gac tac gat tcg gta gaa ggc agc acc agc ggg gca tcc 2255 Glu Glu Ser Asp Tyr Asp Ser Val Glu Gly Ser Thr Ser Gly Ala Ser 740 745 750 tcg gat gaa tgg gaa gat gat agt gac agc tgg gag acg gac aat ggg 2303 Ser Asp Glu Trp Glu Asp Asp Ser Asp Ser Trp Glu Thr Asp Asn Gly 755 760 765 ctg gtg gag gac gag cac ccc ag at ag gag ccc ccc atc cca ccc 2351 Leu Val Glu Asp Glu His Pro Lys Ile Glu Glu Pro Pro Ile Pro Pro 770 775 780 ctg gag cag ccg gtg gcc cct gag gac aag gga gtg gtg atc agt gaa 2399 Leu Glu Glu Pro Ala Pro Glu Asp Lys Gly Val Val Ile Ser Glu 785 790 790 795 gag gca gcc aca gct gcc gtc cag ggg gct gtg gcc atg gct gcc ccc 2447 Glu Ala Ala Thr Ala Ala Ala Val Gln Gly Ala Val Ala Met Ala Ala Pro 800 805 810 815 815 atg gcc ggg ctg atg gag aag gct ggc aag gac ggg cca ccc aag agc 2495 Met Ala Gly Leu Met Glu Lys Ala Gly Lys Asp Gly Pro Pro Lys Ser 820 825 830 ttc cgg gag ttg aaa gag gcc atc ag atc ctg aag aac 2543 Phe Arg Glu Leu Lys Glu Ala Ile Lys Ile Leu Glu Ser Leu Lys Asn 835 840 845 atg act gtg gag cag ctg ctg acg ggc tcg ccc acc tct ccg act gtg 2591 Met Thr Val Glu Gln Leu Leu Thr G Ser Pro Thr Ser Pro Thr Val 850 855 860 gag cct gag aag cca act cgg gag aag aag ttt ctg gat gac atc aag 2639 Glu Pro Glu Lys Pro Thr Arg Glu Lys Lys Phe Leu Asp Asp Ile Lys 865 870 875 aag cta cag gaa aa c ctc aag aag acc ctg gac aat gtg gcc att gta 2687 Lys Leu Gln Glu Asn Leu Lys Lys Thr Leu Asp Asn Val Ala Ile Val 880 885 890 895 gag gag gag aag atg gaa gca gtg ccc gac gta gag cgc aag gag Glu Glu Glu Lys Met Glu Ala Val Pro Asp Val Glu Arg Lys Glu Asp 900 905 910 aag ccc gag ggg cag tca cct gtg aag gct gag tgg ccc agc gaa acc 2783 Lys Pro Glu Gly Gln Ser Pro Val Lys Ala Glu Trp Pro Ser Glu Thr 915 920 925 ccg gtg ctg tgc cag cag tgt ggc ggc aag cct ggc gtc acc ttc acc 2831 Pro Val Leu Cys Gln Gln Cys Gly Gly Lys Pro Gly Val Thr Phe Thr 930 935 940 agc gcc aag ggc gag gc gtc gag gtc ctg gag ttt gca ccc tca aat 2879 Ser Ala Lys Gly Glu Val Phe Ser Val Leu Glu Phe Ala Pro Ser Asn 945 950 955 cat tct ttt aag aaa att gag ttc cag cct cca gaa gcc aag aag ttc 2927 His Ser Phe Lys Ile Glu Phe Gln Pro Pro Glu Ala Lys Lys Phe 960 965 970 975 ttc agc aca gtg cgg aag gag atg gcg ctg ctg gct acc tca ctg cct 2975 Phe Ser Thr Val Arg Lys Glu Met Ala Leu Leu Ala Thr Ser Leu Pro 980 98 5 990 gag ggc atc atg gtc aag act ttt gaa gat aga atg gac ctc ttc tca 3023 Glu Gly Ile Met Val Lys Thr Phe Glu Asp Arg Met Asp Leu Phe Ser 995 1000 1005 gct ctc atc aag ggc ccc act cga acc ccc gac gat ggc ctc tac 3071 Ala Leu Ile Lys Gly Pro Thr Arg Thr Pro Tyr Glu Asp Gly Leu Tyr 1010 1015 1020 ttg ttt gac atc cag ctc ccc aac atc tac cca gcc gtg ccc ccc cac 3119 Leu Phe Asp Ile Gle Leu Pron Tyr Pro Ala Val Pro Pro His 1025 1030 1035 ttc tgc tac ctc tcc caa tgc agt ggc cgc ctg aac ccc aac ctg tat 3167 Phe Cys Tyr Leu Ser Gln Cys Ser Gly Arg Leu Asn Pro Asn Leu Tyr 1040 1045 1050 1055 gacat aag gtg tgt gtc agc ctc ctg ggc acc tgg att gga aag 3215 Asp Asn Gly Lys Val Cys Val Ser Leu Leu Gly Thr Trp Ile Gly Lys 1060 1065 1070 ggg aca gag agg tgg aca agc aag tcc agc ctt ctc cag gtc Gly Thr Glu Arg Trp Thr Ser Lys Ser Ser Leu Leu Gln Val Leu Ile 1075 1080 1085 tcc atc caa ggt ctg atc ctg gta aat gaa cca tac tac aac gaa gcc 3311 Ser Ile Gln Gly Leu Ile Leu Val A sn Glu Pro Tyr Tyr Asn Glu Ala 1090 1095 1100 ggc ttc gac agt gac cga ggc ctg cag gaa ggc tat gaa aac agt cgc 3359 Gly Phe Asp Ser Asp Arg Gly Leu Gln Glu Gly Tyr Glu Asn Ser Arg 1t t11at 1115at gag atg gcg ctg atc cgc gtg gtg cag tcc atg acc cag 3407 Cys Tyr Asn Glu Met Ala Leu Ile Arg Val Val Gln Ser Met Thr Gln 1120 1125 1130 1135 ctg gtg cgg cgg ccc ccc gag gtc ttt gag cag gag atc ag 3455 Leu Val Arg Arg Pro Pro Glu Val Phe Glu Gln Glu Ile Arg Gln His 1140 1145 1150 ttt agc act ggt ggc tgg cgg ctg gtg aac cgt atc gag tcc tgg ctg 3503 Phe Ser Thr Gly Gly Trp Arg Leu Val Asn Arg Ile Glu Ser Trp Leu 1155 1160 1165 gaa acc cat gcc ctg ctg gag aag gcc cag gca ctg ccc aac ggg gtg 3551 Glu Thr His Ala Leu Leu Glu Lys Ala Gln Ala Leu Pro Asn Gly Val 1170 1175 1180 ccc aag gcc agc gc cg ccc cca gct gta gcc gag ctg tca 3599 Pro Lys Ala Ser Ser Ser Pro Glu Pro Pro Ala Val Ala Glu Leu Ser 1185 1190 1195 gac tcc ggc caa caa gaa cct gag gat gga ggg cca gcc cca gga g ag 3647 Asp Ser Gly Gln Gln Glu Pro Glu Asp Gly Gly Pro Ala Pro Gly Glu 1200 1205 1210 1215 gcc tcc cag ggc tca gac tca gag ggc ggt gcc cag agc ctg gcc tca 3695 Ala Ser Gln Gly Ser Asp Ser Glu Gly Aly Gln Ser Leu Ala Ser 1220 1225 1230 gct agc agg gac cac aca gac cag act tcg gag acc gca cca gac gca 3743 Ala Ser Arg Asp His Thr Asp Gln Thr Ser Glu Thr Ala Pro Asp Ala 1235 1240 1245 tcg gtg cca ccc agt gtg aaa cca aag aag cgg aga aag agc tac cgg 3791 Ser Val Pro Pro Ser Val Lys Pro Lys Lys Arg Arg Lys Ser Tyr Arg 1250 1255 1260 agc ttc tta cct gag aag agt ggc tac cct gac atc ggc ttc ccc ctc 3839 Ser Phe Pro Glu Lys Ser Gly Tyr Pro Asp Ile Gly Phe Pro Leu 1265 1270 1275 ttc cca ctt tcc aag ggt ttc atc aag agc atc cgg ggt gtc ctg acg 3887 Phe Pro Leu Ser Lys Gly Phe Ile Lys Ser Ile Arg Gly Val Leu Thr 1280 1285 1290 1295 cag ttc cgg gct gcc ctg cta gag gca ggc atg ccg gag tgc aca gag 3935 Gln Phe Arg Ala Ala Leu Leu Glu Ala Gly Met Pro Glu Cys Thr Glu 1300 1305 1310 gac aag tagctg ccag gcacagagga aagagcatca ccgtgggaga ggccagccgc 3991 Asp Lys cgcctgctca ctcccccccg gaatcacccc tcttcccatg cccctctgtc cccactgcaa 4051 acccactgcc ctcttctccc caaggtgagt ttgatgctga agtgcaagaa gtgtgttgag 4111 atgctgccgt ttctattttg aagcgagctt tcaacaggcg ggtcccctgt ggcaaagaaa 4171 atcggaaccc tgttgccgat tttccatttg tcaccccagc agaatgtccg gcacttgctc 4231 ccttgctgcc ccttctcagg tcagaggcgg gtgttccagg gcctgccgcg gggctctctg 4291 ggccggttcc ctgcagaccc gcaggagagc acatgtgcct tgcatgaagt gtgggttgcg 4351 ccaacaattc ccctggtccc tttcaacctg tttagttcaa ctcaagcctc cctgtgtccc 4411 agaccctcct gctgccacca ccacccaggt cctccctagt cctccagcgt caacactatc 4471 ccttgggagt tgtagctgct gtcactgact cccggctata catggcctgt cgaccacgtt 4531 atagccctca ggcctgttga acttgctctc taagagaggt tgggaccagg ctaggttccg 4591 ggtgacgccc aggagaggtg gtggccttca cacatgcaca tggagttgag gaccagggag 4651 ctgcagggaa agcaacagct ataggtgcct tgctcttctg tcggaggctg ctgggggcaa 4711 gagcagctgc acaaggccag ggcaagtgct agggcccctc ccccatcaca tggtcacact 4771 gggacaggcg tgca gctcac tgaactccaa gcgagccagc cctctcttgg actagaaggc 4831 ctactgtcag cccttcgctt acaaactgca ggctcaatcc gaaggggacg gccggcgggg 4891 gctctcctag tgcccagaga caggcccaga ggtttacaag ttttctaagc ttttgataat 4951 gtgaagctcc aggccgagag gatgctgttg agcacattgc agctatgtaa tttttggtgt 5011 atgtatgtaa tatttaaggt tggaaaaaaa aactcaaaag caaagatatt aactcttatt 5071 ag 5073 <210> 213 <211> 5514 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3432) .. (5195) <400> 213 gttccgtggc tctgacgtcc agggaacagc aggacgactc ttgaaacaaa atgagacgtg 60 gtctaaagcc ctttccctga cccacgcgtt gaaacgctgc cacgagtcgt ccgtttcccc 120 agggaatcgt ctcggtgggg gtgccggggc ctggctgggg gtcctgccgg gctcacggcc 180 agggccggtc ttggcaggag aacgtgtctc tggctgacat cctctccctg cgggaccgcg 240 gcctcagcga gcaggaagcc tgggccgtgt gcctggagtg cagcctgtcc atgcggagcg 300 tggcccacgc cgccatcttc cagagcctgt gcatcacgcc cgacaccctg gccttcaaca 360 ccagcgggaa cgtgtgtttc atggagcagc tcagcgacga ccctgagggt gccttcgttc 420 cccccgagtt cgacgtgacc gggaacacct ttgaggcgca catctactct ctgggggcca 480 cgctgaaggc cgccctcgag tacgtggcag agcccacact ggaacccagg ctgagccaag 540 acctcgaggc gctgctgagc cggatgcagg cggaggaccc cggggaccgg ccggaccttg 600 agagcatcat cgcgctgtgt gaagagaagc tgcagctcac atcctcctgt cgcgtgtgcc 660 ggagcctctc tgctgtgggg aggagggtcc tctccatcga gtccttcgga gcgctgcagg 720 atgtcagcga gagcagctgg cgggagagac ctgccccagg aaacgctggg cccaggaggc 780 cgcccgggga ccccagcact gacccggagg ttctgccgac ccccgaaggc ccggagtctg 840 agaccagccg gggccccaga gcctccccaa ccaaggctct gctgtccacc ccggtgagaa 900 atggcgagag ccacagccgg gaggggctgg ccggcctcgt cctggatgcc gagcgcaccc 960 tcggggagct ggacagagac gccctcagga gaagccgcct gcggaaggtg cagacgttcc 1020 ctaggctgct gtccgacagc cccgaggcca ccctctgcct gccgctgacc cgcgggaaaa 1080 gccagctgcc catatcggaa ttattctctc cggaccccag gaaggccttt ctggacagga 1140 aaaatggcct ttctagcttc caggctcagc ccaaatgcag gctgtggccg gagcaggagc 1200 cggaacacca gctgggacgg gttccctgtg caggccgcag cacggacagg ggccctgggg 1260 tgcccggcag tccaggacag cccgagactt cacaccccag ccaggggcca gcagaggccc 1320 ctgcagaccc tcgagatgct agcggtgaag cccagactcc cagggacgat gagagaattc 1380 cagaaggagc taggcagctg gaaagtgcag ccgcggagca gtgggtgtcc ctgcaggacc 1440 tcctgtccca gctgggccgg cccttccggg agtacgagct gtgggccctg tgcctggcct 1500 gcctccgcgc actgcagaca cgccctgagc acccaggtga cgcacgcacc atcccatccc 1560 ccccgccgtc cccacccccc actgctgttc caccccccac cgccgtccca cacccccgcc 1620 gtcccacccc ccacaccgtc ccacgccccc ccactgtccc atcacccctg ccgtcccatg 1680 cgtaactggc ccccacc tga accaagggac ccaggggcag ccaggacagt gtctccggtg 1740 aacggaacag gcggctcccg tctggagcac cttgtgggtg cctgctgggt tgcagcaccg 1800 agggaggtgt ggggacagat gcctgcaagg tgggccttga aaccggtgac tgtgccgtaa 1860 agaggaacgg ggactttgcc atggccctcg cccacacatt ctcaacacag tgacattgtc 1920 cccagggagg cagcaattgg ctttggagtg gggagggaat cttcagcatt gcacgggtct 1980 gccccgtcaa agcctagccc tgccagacat cagggcagac ggacggtgca tctgagacgt 2040 aaaaacgtcc tgggggtgat gagggcagca tctgaaaggg ctgggggaga ggccatcgga 2100 gacacacccg gctccagtgt ccgtccaccg tgagcccgtg gctgccccgt gggccctgac 2160 tcgggacggg gcctgtgaca cgggggcttc aagttaccgt gttctccctg ccgctcggct 2220 ccctttcagc cgcagatatg ccgctgcagc cactgtgtcg gctggggcag cgctaccctc 2280 ggggagggct gggaggaggc agctccgagg accccggggg ctggggtcag gccatgtgcg 2340 tgcactggca ggtgcgtgcc cgtgcaatgg ggaggctggg gggctgcccg gcctgactga 2400 ggctccgcag ctccttcccc ccagccagcc ccaagtgcgg ggcagcatgc atacccgccc 2460 tgacccaagc tctgccacag cctacctgtg tctggactcc gtgctggttg ctgaggacgg 2520 ggctgtgctc ttccagccac cc cctgccaa cggttcctat gactcgttct ttctggctcc 2580 cgagctggca gaggagaggc tggtaactga aaaggcctct gtgtactgtg tggccgccgt 2640 tctgtggacc gcagccaagt tcagcgtccc ccgcaaccac aagctggccc tgccacgcag 2700 gctcaagacc ctcctcctgg acatggccag gcgcagtgcc ccggagcggc cgtccgcggc 2760 tgaggccatc aaggtgtgcg gcagctacct cctccagcga ggcatggaca gccggaaaat 2820 ccttgcccac ctcagagctt ccatctgcca ggtgtaccag gaggaagaga ccatcagcct 2880 ccaaaacgcc ttctcagtgg ttgaactgaa gcccagtgtg gcaccagccc cagagcccag 2940 cccaggtggg gacctgacca gcccctgctg ccccaccagc tcctgcacct gacaccacag 3000 ctgcccccac ctctgcatgg acagacacag ccgggcacct ctcggaaacc cgggaagcaa 3060 gtccagagct cggccaacgt ggcccatgca gcccagcctg cctgcccctg ccagccccca 3120 tctcccaaaa ctcccagtcg ctcaggcccc agctccaggt tctcactccc atctcccagc 3180 agctggccct cccaagccca catctggaga cccccagagt ccacacagag cccaccccac 3240 ccccgtactg agccctgctc agcaggcccc tccaaggctt ctggtggggc ctggtcttgc 3300 tggcccgtcc ccgcctgctg gccctccccc aagcaccagt ctcacccacc ctcccattcc 3360 agggcccagc acagaggaag cccccag ggc catgcgggag gggacgcggc accacgcact 3420 gggtgggatg a gca ctg ggt ggg atg agc cgg tgg tgc ggc acg tgc tgg 3470 Ala Leu Gly Gly Met Ser Arg Trp Cys Gly Thr Cys Trp 1 5 10 gg cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc cc ccc ccc ccc ccc ccc ccc ccc ccc ccc ccc ccc cca ggc ttc 3518 Gly His Ser Ala Arg Pro His Pro Gln Pro Pro Gly Ser Pro Gly Phe 15 20 25 ctg ccg gtg aac agc gac acc ggg ctt gtg gct gtg cca ggg ccc gtg 3566 Leu Pro Val Asn Ser Asp Thr Gly Leu Val Ala Val Pro Gly Pro Val 30 35 40 45 ccc ggc cag cac ccc tgc ggt gaa gaa gcc acc cag ctg cct gca gcg 3614 Pro Gly Gln His Pro Cys Gly Glu Glu Ala Thr Gln Leu Pro Ala Ala 50 55 60 ttc acc tcc gag gcc acg cac ttc aag ccc att gtc ctc gcg cag aac 3662 Phe Thr Ser Glu Ala Thr His Phe Lys Pro Ile Val Leu Ala Gln Asn 65 70 75 gca agt gtg gcc agg gac cag cct gcc ttg gcc cag gag gag tcc gag 3710 Ala Ser Val Ala Arg Asp Gln Pro Ala Leu Ala Gln Glu Glu Ser Glu 80 85 90 gag agg ggc ggc cag agg gag gga gaa ggt gag gag aag ctc tcc ctg 3758 Glu Arg Gly Gly Gln Arg Glu Gly Glu Gly Glu Glu Lys Leu Ser Leu 95 100 105 gag gcc cac gct ggg tcc ccc agc ctg aag acg cct gac ggg ccg gtg 3806 Glu Ala His Ala Gly Ser Pro Ser Leu Lys Thr Pro Asp Gly Pro Val 110 115 120 125 cct ggt ccg ggg cca cag gga gca gcc cca gag cct ctt ggg gcg tca 3854 Pro Gly Pro Gly Pro Gln Gly Ala Ala Pro Glu Pro Leu Gly Ala Ser 130 135 140 gtg cag cgt gac tca gcc cag ggc cgc ccc tgc cct cca ccc cag gcc 3902 Val Gln Arg Asp Ser Ala Gln Gly Arg Pro Cys Pro Pro Pro Gln Ala 145 150 155 cca gca aac cag cca gag ggg gcc tca tcg gca gct ccc ggc tct cca 3950 Pro Ala Asn Gln Pro Glu Gly Ala Ser Ser Ala Ala Pro Gly Ser Pro 160 165 170 gtc ccc gcc ccg ccc acg aag gca tct gcg ctg ccc gta gag caa ggg 3998 Val Pro Ala Pro Pro Thr Lys Ala Ser Ala Leu Pro Val Glu Gln Gly 175 180 185 ccg gct gag ccg atc cca cct gga gtt gct tcc ggg ggc ctc agg ccc 4046 Pro Ala Glu Pro Ile Pro Pro Gly Val Ala Ser Gly Gly Leu Arg Pro 190 195 200 205 gac gcc ctg ggg ccc acc acg gcc cac cac ggc cca cgc cac ccg ccc 4094 Asp Ala Leu Gly Pro Thr Thr Ala His His Gly Pro Arg His Pro Pro 210 215 220 aag ccc cca cga agc aag gcc acc gag cgc ccg ggc cag gag cca gag 4142 Lys Pro Pro Arg Ser Lys Ala Thr Glu Arg Pro Gly Gln Glu Pro Glu 225 230 235 ggc ccc ggg gcc acc cct gcc ggg gaa cgt gat gac cag agt cca gac 4190 Gly Pro Gly Ala Thr Pro Ala Gly Glu Arg Asp Asp Gln Ser Pro Asp 240 245 250 agt gtc cca gag agg ccg cgg ccc gca gac cgg agg ctc tgt ctg ccc 4238 Ser Val Pro Glu Arg Pro Arg Pro Ala Asp Arg Arg Leu Cys Leu Pro 255 260 265 tgc gtg gat gcc tcg cca ctc cca ggg agg acg gcc tgc ccg tcg ctg 4286 Cys Val Asp Ala Ser Pro Leu Pro Gly Arg Thr Ala Cys Pro Ser Leu 270 275 280 285 cag gag gcc acg cgc ctc atc cag gag gaa ttt gcc ttc gat ggc tac 4334 Gln Glu Ala Thr Arg Leu Ile Gln Glu Glu Phe Ala Phe Asp Gly Tyr 290 295 300 ctg gac gag gg gct ctg atc atg ggg gag tac atc ttc gcc 4382 Leu Asp Asn Gly Leu Glu Ala Leu Ile Met Gly Glu Tyr Ile Phe Ala 305 310 315 ttg aaa gat ctc acc ttt gcc act ttc tgt ggc gcc att tcc gag aag 430 ys Asp Leu Thr Phe Ala Thr Phe Cys Gly Ala Ile Ser Glu Lys 320 325 330 ttc tgt gac ctg tac tgg gat gag aag ttg ctg cag aac ctc ttt aag 4478 Phe Cys Asp Leu Tyr Trp Asp Glu Lys Leu Leu Gln Asn Le Lys 335 340 345 gtg gtc aac ggg cag gcg tca ccc tcc cca agc acg gcc gag gag gct 4526 Val Val Asn Gly Gln Ala Ser Pro Ser Pro Ser Thr Ala Glu Glu Ala 350 355 360 365 ggg tca cag ctc gag ggc agc caag ccc cgc tcc ccg tcc agc aag 4574 Gly Ser Gln Leu Glu Gly Ser Gln Ser Pro Arg Ser Pro Ser Ser Lys 370 375 380 agg ccg tcg ctg cac cgc ctg gga aaa gag aag cca gcc atg gcc agg 4622 Arg Pro Ser Leu His Arg Leu Gly Lys Glu Lys Pro Ala Met Ala Arg 385 390 395 acc agc agc agg gcc ccc tgc tca ccc acc tcg gtg tcg gat gtg gac 4670 Thr Ser Ser Arg Ala Pro Cys Ser Pro Thr Ser Val Ser Asp Val Asp 400 405 410 tcg gac gca ctg tca cgg gga aac ttc gag gtg ggg ttt cgg cct cag 4718 Ser Asp Ala Leu Ser Arg Gly Asn Phe Glu Val Gly Phe Arg Pro Gln 415 420 425 agg tcc gta aaa gcc gag aga gcg cag cag cct gag gct gg c gag gac 4766 Arg Ser Val Lys Ala Glu Arg Ala Gln Gln Pro Glu Ala Gly Glu Asp 430 435 440 445 aga cgg cca gct ggc ggg gcc tca gac gtg gag gca gtg acc cga ctg 4814 Arg Arg Pro Ala Gly Gly Ala Ser Asp Val Glu Ala Val Thr Arg Leu 450 455 460 gcc agg tcc aaa ggg gtc ggc cca gcc ttg tcc ccc ggc cca gcc gga 4862 Ala Arg Ser Lys Gly Val Gly Pro Ala Leu Ser Pro Gly Pro Ala Gly 465 470 475 475 ttc cag agc tc agc ccc ggc tgg tgc agc gcc ttc tac gag gcc gac 4910 Phe Gln Ser Cys Ser Pro Gly Trp Cys Ser Ala Phe Tyr Glu Ala Asp 480 485 490 tgc ttc ggg gcc gac gtc cac aac tac gtg aag gac cg g958 Phe Gly Ala Asp Val His Asn Tyr Val Lys Asp Leu Gly Arg Gln 495 500 505 cag gcg gac ggg gcc ctg ccc gac gcc cag agc ccg gag ctg gaa cag 5006 Gln Ala Asp Gly Ala Leu Pro Asp Ala Gln Ser Glu Leu Glu Gln 510 515 520 525 cag ctc atg atg gag aaa aga aac tac cgc aag acc ctg aag ttc tac 5054 Gln Leu Met Met Glu Lys Arg Asn Tyr Arg Lys Thr Leu Lys Phe Tyr 530 535 540 540 cag aaa ctc ga caa gag g agg aac aaa ggt aag gcc cct gtg 5102 Gln Lys Leu Leu Gln Lys Glu Lys Arg Asn Lys Gly Lys Ala Pro Val 545 550 555 ggc aca ggt ccg aga ccc cgg ctg cag gca gcc cgg ccc cca ccc act 5150 Gly Thrly Arg Pro Arg Leu Gln Ala Ala Arg Pro Pro Pro Thr 560 565 570 ctg ctc cac cca cag gtt ccg acg tca aga cca tgc tgt cca agc 5195 Leu Leu His Pro Gln Val Pro Thrr Ser Arg Pro Cys Cys Pro Ser 575 580 585 tgaaagggca gctagaagaa atgaaatcca gggtgcaatt cctcagcttg gtcaagaagt 5255 atctgcaggc aagtgggctc cgggccccgc tctgccccgt gaggcagtag cttcagacgg 5315 gcctcccact gttggatgct gtaaatctgt ccgtgtgaag ttataaaagg ggccctgatt 5375 tgagggtcca atgccaggaa gccctggggc gaggggcaga gtgaccaagc gcccgtgtcc 5435 cgctccggca ggtcatgtac gcggaacgct ggggcctgga gccctgcacc ctcccagtga 5495 tcgtgaacat cgcggccgc 5514 <210> 214 <211> 4588 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (1722) <400> 214 caa aaa tcc atg gaa agt agt ctt tgt gtc atg gct aat ccc acc tat 48 Gln Lys Ser Met Glu Ser Ser Leu Cys Val Met Ala Asn Pro Thr Tyr 1 5 10 15 gat atc gac ccc aac tgg gat gcc agc agt gct ggt tct tcc atc agc 96 Asp Ile Asp Pro Asn Trp Asp Ala Ser Ser Ala Gly Ser Ser Ile Ser 20 25 30 tat gaa ctc aaa gga ctg gac att gag tct tat gac tcc ttg gaa agg 144 Tyr Glu Leu Lys Gly Leu Asp Ile Glu Ser Tyr Asp Ser Leu Glu Arg 35 40 45 cct ttg cgc aag gag aga cct gtc ccc tca gca gca aac agc att tcc 192 Pro Leu Arg Lys Glu Arg Pro Val Pro Ser Ala Ala Asn Ser Ile Ser 50 55 60 agc tta acc act ctc agt att aag gat aga ttt tcc aac agc atg gaa 240 Ser Leu Thr Thr Leu Ser Ile Lys Asp Arg Phe Ser Asn Ser Met Glu 65 70 75 80 tcc ctc tcc agc cgg cgt ggg ccc tct tgc aga cag ggc cga ggc atc 288 Ser Leu Ser Ser Arg Arg Gly Pro Ser Cys Arg Gln Gly Arg Gly Ile 85 90 95 cag aag ccg cag aga caa gca ctt tat cga gga ctt gag aat cgg gag 336 Gln Lys Pro Gln Arg Gln Ala Leu Tyr Arg Gly Leu Glu Asn Arg Glu 100 105 1 10 gaa gta gtg ggt aaa atc cga agc ctt cat aca gat gcc ttg aag aaa 384 Glu Val Val Gly Lys Ile Arg Ser Leu His Thr Asp Ala Leu Lys Lys 115 120 125 ctg gct gtt aaa tgc gaa gac ctt ttc atg gct ggg cag aaa gac cag 432 Leu Ala Val Lys Cys Glu Asp Leu Phe Met Ala Gly Gln Lys Asp Gln 130 135 140 ctc cgt ttt gga gtg gac agc tgg tca gac ttc agg cta acc agt gac 480 Leu Arg Phe Gly Val Asp Ser Trp Ser Asp Phe Arg Leu Thr Ser Asp 145 150 155 160 aaa cca tgt tgt gag gca ggt gat gcg gtt tac tat act gct tca tat 528 Lys Pro Cys Cys Glu Ala Gly Asp Ala Val Tyr Tyr Thr Ala Ser Tyr 165 170 175 gca aaa gat cca ctt aat aac tat gca gtc aag atc tgt aag agc aaa 576 Ala Lys Asp Pro Leu Asn Asn Tyr Ala Val Lys Ile Cys Lys Ser Lys 180 185 190 gct aaa gaa tct cag cag tat tat cac agc ttg gct gtc cgg cag agt Lys Glu Ser Gln Gln Tyr Tyr His Ser Leu Ala Val Arg Gln Ser 195 200 205 ctg gct gtc cat ttt aac att cag cag gac tgt ggt cat ttc ctt gct 672 Leu Ala Val His Phe Asn Ile Gln Gln Asp Cys Gly His Phe Leu A la 210 215 220 gaa gtc cct aac cgt ctg ctt ccc tgg gag gat cca gat gac cct gaa 720 Glu Val Pro Asn Arg Leu Leu Pro Trp Glu Asp Pro Asp Asp Pro Glu 225 230 235 240 aag gat gag gat gac atg gaa gag act gaa gaa gac gcc aaa gga gaa 768 Lys Asp Glu Asp Asp Met Glu Glu Thr Glu Glu Asp Ala Lys Gly Glu 245 250 255 acg gat ggg aaa aac cca aag ccc tgt tct gaa gca gca tca tcc cag 816 Thr Asp Gly Lys As Lys Pro Cys Ser Glu Ala Ala Ser Ser Gln 260 265 270 270 aaa gag aat cag gga gtc atg agc aag aag cag agg agc cac gtt gtg 864 Lys Glu Asn Gln Gly Val Met Ser Lys Lys Gln Arg Ser His Val Val 275 280 285 gtc atc acc agg gag gtt cca tgt ctt act gtg gct gat ttt gtg cga 912 Val Ile Thr Arg Glu Val Pro Cys Leu Thr Val Ala Asp Phe Val Arg 290 295 300 gac tct ctg gcc cag cat ggg aaa agc cct gat ttg tat gag agg cag 960 Asp Ser Leu Ala Gln His Gly Lys Ser Pro Asp Leu Tyr Glu Arg Gln 305 310 315 320 gtg tgt ctg ctg ctc tta cag cta tgc tct ggt ctt gag cac ctc aaa 1008 Val Cys Leu Leu Leu Leu Gln Leu Cys Ser Leu Glu His Leu Lys 325 330 335 ccc tac cat gtc act cac tgc gat cta cgc cta gag aac ctg cta ctt 1056 Pro Tyr His Val Thr His Cys Asp Leu Arg Leu Glu Asn Leu Leu Leu 340 345 350 gtc cac tac cag cct ggg ggg act gcc caa ggc ttt ggg cct gca gag 1104 Val His Tyr Gln Pro Gly Gly Thr Ala Gln Gly Phe Gly Pro Ala Glu 355 360 365 ccc agc ccc acc tca tct tat ccc act agg ctt ata gtg agc aac ttc 1152 Pro Ser Pro Thr Ser Ser Tyr Pro Thr Arg Leu Ile Val Ser Asn Phe 370 375 380 tct cag gcc aag cag aag agc cat ctg gtg gac ccc gag atc ctc cgg 1200 Ser Gln Ala Lys Gln Lys Ser His Leu Val Asp Pro Glu Ile Leu Arg 385 390 395 400 gac cag tct cgc ctt gcc cca gag atc ata aca gct acc cag tat aaa 1248 Asp Gln Ser Arg Leu Ala Pro Glu Ile Ile Thr Ala Thr Gln Tyr Lys 405 410 415 aag tgt gat gag ttc cag aca ggc atc ctc atc tat gag atg ctg cac 1296 Lys Cys Asp Glu Phe Gln Thr Gly Ile Leu Ile Tyr Glu Met Leu His 420 425 430 cta ccc aac ccc ttt gat gag aac cca gag ctg aag gag agg gaa tac 1344 Leu Pro Asn Pro Phe Asp Glu Asn Pro Glu Leu Lys Glu Arg Glu Tyr 435 440 445 aca cga gca gac ctg cct cgc atc cca ttc cgc tcc ccc tac tcc cgg 1392 Thr Arg Ala Asp Leu Pro Arg Ile Pro Phe Arg Ser Pro Tyr Ser Arg 450 455 460 ggt ctg cag cag ctg gcc agc tgc ctc ctg aat ccc aac cct tct gag 1440 Gly Leu Gln Gln Leu Ala Ser Cys Leu Leu Asn Pro Asn Pro Ser Glu 465 470 475 475 480 cgg atc ctc att tca gac gcc aaa ggc atc gt ctc tgg 1488 Arg Ile Leu Ile Ser Asp Ala Lys Gly Ile Leu Gln Cys Leu Leu Trp 485 490 495 ggc ccc cgc gaa gat ctc ttc cag act ttc acc gcc tgc cct agc cta 1536 Gly Pro Arg Glu Asp Leu Phe Thr Ala Cys Pro Ser Leu 500 505 510 gta cag agg aac acc ctg ctc caa aac tgg cta gac atc aag cga aca 1584 Val Gln Arg Asn Thr Leu Leu Gln Asn Trp Leu Asp Ile Lys Arg Thr 515 520 525 ctg ctc atg atc aag ttt gct gag aag tcc ctg gac agg gaa ggt gga 1632 Leu Leu Met Ile Lys Phe Ala Glu Lys Ser Leu Asp Arg Glu Gly Gly 530 535 540 atc agc ctt gag gac tgg ctt tgt gct cag tat ttg gct ttt gcc act 1680 Ser Leu Glu Asp Trp Leu Cys Ala Gln Tyr Leu Ala Phe Ala Thr 545 550 555 560 aca gac tcc ctc agt tgt att gtg aaa att ctg cag cac cgt 1722 Thr Asp Ser Leu Ser Cys Ile Val Lys Ile Leu Gln His Arg 565 570 taatgtgtac ctggatgatg cttttactac atcttcacct tcttcatgtc acccatgcac 1782 ttcccctccc tagtgctcac tccaaattca aggaaagaag aaagacaaac ctctatccct 1842 gtccgtgaac aagtgggtct attcagaaag gttatccact gccccagatt gaatgagaag 1902 ctgagtctgt cttaacttta cagaaattca gctgcacaaa cttgcagttg ccttcccttg 1962 aaacaccttc tatcctaata gtcccataaa tgcaggtaaa aatgaaaatc catattcttg 2022 aagggacagc ttctttggta tgaactcagc cagtgagctg tgtccatttc ctccataatt 2082 ctggatatca cctatctttt tagcaccaag tatttattct cactagcagt agacagactt 2142 aaccagtctc taccacgacc cagtagactc tgacaacaga ctcttccttt aaggtgtcaa 2202 caactgactt actaggcagg actgccatcc ttagcatcag cccagttttg gttaccaggg 2262 actatatctt ttgttccagg agagagtaga aagagaga gagatcccat ccttgggca tg ccttgggca tg ccttgggtca t ccttgggca t ccttgggtca ccttgggcc gcca ctgcctgatt ctccactctg tccccacttg ccagtgaagt 2442 ttggatttat cagccacttg tggcccatta cagagctgac ccaaggtggt gtcaccaatg 2502 cctcagcagg gtggagtgca gttcagagct tataaatagc tggcagggca tgaggagatg 2562 attttcttgc atgtgcaatt ctctaggggc catcaggaaa cagagtttaa agtacccttt 2622 gattactgtc agaactgtca gcatttgcag ttttccccga gcagtaattg gccagctccc 2682 ttctatcagt agccagtgtt aactagttta ccaaatgctg taaacaattg ccctgaatga 2742 aatagctgtc agtggagctc taagatctcc tttagagggc acagtgaggt gggctgttgg 2802 gatggccgta ggcaggggag aggaagaagg ccactgatga gactgctgac ctcctcagaa 2862 tgttgacctc ttctagagag actgcctccc agtgtttaag tggctcattg ctccttctga 2922 ctctgtaaaa tggctctgga ggacagctca caggaattct gattgctgag ttgacaagga 2982 ttgaaaattc cgctccagcc taatgagtga acaggatggc tgcccacaaa accaagttat 3042 tagctttatg tcatcgaagc tcatattctc aaaggcccaa agtgctgtgc cgagacaaat 3102 ccaagtgctg ctcttgctga agtgcgcact gaagtccagc tgtccgtgct tacagcagtg 3162 ccaaaagtgg ggattccatg gaccaaaaac ggtgccataa gggaagccag aagagttgca 3222 gtgcaagatc ctgggagaga t tataccaaa gaaatcaagc ctttttatcc tgatgcttct 3282 aagatgatga gggtgagctg tgacagatgc tgtgggaggg gagttcacat acattccatg 3342 tcaaggcatt tagctgataa atccatcctc agaaaagcac ctttttaaaa agaagtccat 3402 tttgtatatt agaagatgat gatgatgatg aagatgaaga aagccctggc agatacaaag 3462 ttcctcagta tttaaggaga aggatctctt ccatgtcccc ttgacatgac tgtggctatt 3522 gcccaaacct cagcttgaga acatcatata atactgagag cggaagattt ttttaaagag 3582 atatggtagt ttaaataggt ttgtttaaag aactcttggg aaatttctta acaaattgta 3642 attgttttta taaaccttcc tacagagttg tgtaccattc atcatcacca tcatttaata 3702 tctgtaagtg cccagaaggt acaaggtgct atacagccgt taaacacccc ctccctgcaa 3762 ctgtttaaaa ttagaataga tttttgcatc aaccactgct agaagctttc cccacctagg 3822 tgggctgcaa gggcctgcat tcccaacatc ccattacatg tttcccactc cagaaagtct 3882 ctgggtttat tccagctttt tatcttgacg tgtcccattc acccccatgg tttggtttgg 3942 tttggtttgg ttttttaaat caagaaagtt tcagggaatc aaaagaggtc ggacattttt 4002 taacctagca gaagtacaga gtcatatatt ttgctacgaa tattgttgta gtacagaaaa 4062 cccactttgc ccgttagtgt gtggat agta tgtgtgtgtc cgcactcatg ataacttgaa 4122 tgttgaacca gacatagggt tcatttttga aaggttaaac cacactgttt caggaacttg 4182 ctccaaatac tacttggtta tcccttcctt taccagttag aactaaagag tgtgatgtat 4242 gaacacactg ggttgggatt ttctgttgag gatatgcagg gcattttggc atgaggcaaa 4302 tacagaagca agatttcatt ctacttggtg atttgaatca tgacagtcct cattccaatc 4362 tctctttaat tctctctggc cctgcccaca ctctgtattt gaaaatcttg tttttgctct 4422 ttccggagct tcacccctct acttacatat tgtaaagttg tataaatcta tcattgaaag 4482 gtcctctctg ccagcagtgg tgccaccctt tggtttgctg tggtactttg ctgtgtactc 4542 cgtggcatca tgttactgtg taaataaatt cattttaata cacact 4588 <210> 215 <211> 4221 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (52) .. (1251) <400> 215 agggcagtcc agatgaaaag agtaccaatg aatctgcctc cagctgaata a acc atg 57 Thr Met 1 gag agg aaa aac cca tcc aga gag agc ccc aga aga ctc tct gcc aaa 105 Glu Arg Lys Asn Pro Ser Arg Glu Seru Arg Glu Seru Arg 10 15 gta ggc aaa ggc aca gag atg aag aaa gtg gct cgt cag ctt ggg atg 153 Val Gly Lys Gly Thr Glu Met Lys Lys Val Ala Arg Gln Leu Gly Met 20 25 30 gct gct gct gag tca gac aag gac tct ggc ttt tca gat ggg agc tcg 201 Ala Ala Ala Glu Ser Asp Lys Asp Ser Gly Phe Ser Asp Gly Ser Ser 35 40 45 50 gaa tgt ctg agc tct gca gag cag atg gag tcc gag gac atg ctg agc 249 Glu Cys Leu Ser Ser Ala Glu Gln Met Glu Ser Glu Asp Met Leu Ser 55 60 65 gcc tta ggc tgg agc aga gaa gac agg ccg agg cag aac tcc aaa act 297 Ala Leu Gly Trp Ser Arg Glu Asp Arg Pro Arg Gln Asn Ser Lys Thr 70 75 80 gca aag aat gcc ttc cct acc ctg tct ccc atg gtc gtc atg aag aat 345 Ala Lys Asn Ala Phe Pro Thr Leu Ser Pro Met Val Val Met Lys Asn 85 90 95 gtg ctt gtc aaa cag ggc agc agc tca tcc cag ctc cag tcg act 393 Val Leu Val Lys Gln Gly Ser Ser Ser Ser Gln Leu Gln Ser Trp Thr 100 105 110 gtc cag ccc tcc ttt gaa gtg atc tca gca cag cca cag ctc tta ttc 441 Val Gln Pro Ser Phe Glu Val Ile Ser Ala Gln Pro Gln Leu Leu Phe 115 120 125 130 ctt cat cca cct gta cca tct cct gtc agt cca tgt cac act ggt gag 489 Leu His Pro Pro Val Pro Ser Pro Val Ser Pro Cys His Thr Gly Glu 135 140 145 aaa aag tcc gac tcc agg aac tac ttg ccc att ctg aat tct tac acc 537 Lys Lys Ser Asp Ser Arg Asn Tyr Leu Pro Ile Leu Asn Ser Tyr Thr 150 155 160 aaa ata gcc cca cat cca ggc aaa agg ggc ctt tcc ctt ggc cca gaa 585 Lys Ile Ala Pro His Pro Gly Lys Arg Gly Leu Ser Leu Gly Pro Glu 165 170 175 gaa aaa gga aca agt gga gtg cag aag aaa atc tgt act gag aga ctt 633 Glu Lys Gly Thr Ser Gly Val Gln Lys Lys Ile Cys Thr Glu Arg Leu 180 185 190 ggg cct agc ttg tct tcc agt gag cca acc aag gct ggt gct gtc cca 681 Gly Pro Ser Leu Ser Ser Ser Glu Pro Thr Lys Ala Gly Ala Val Pro 195 200 205 210 tcc agt ccc tcg acg cca gca cca ccc agc gcc aaactt gcc gag gac 729 Ser Ser Pro Ser Thr Pro Ala Pro Pro Ser Ala Lys Leu Ala Glu Asp 215 220 225 tca gct ctg cag ggt gtg ccc tct ctg gtg gca ggt gga agt cca cag 777 Ser Ala Leu Gln Gly Val Pro Ser Leu Val Ala Gly Gly Ser Pro Gln 230 235 240 act ctt cag ccg gta tcc agc agt cac gtg gct aaa gct ccc agt ctg 825 Thr Leu Gln Pro Val Ser Ser Ser His Val Ala Lys Ala Pro Ser Leu 245 250 255 acc ttc gct tcc ccc gcc agt cct gtc tgc gca tca gac agc act ctc 873 Thr Phe Ala Ser Pro Ala Ser Pro Val Cys Ala Ser Asp Ser Thr Leu 260 265 270 cat ggg tta gag agc aac tct ccc ctt tca cca ctg tcc gct aat tat 921 His Gly Leu Glu Ser Asn Ser Pro Leu Ser Pro Leu Ser Ala Asn Tyr 275 280 285 290 agc tca cct tta tgg gct gca gag cac ctc tgc cgc agc cca gat atc 969 Ser Ser Pro Leu Trp Ala Ala Glu His Leu Cys Arg Ser Pro Asp Ile 295 300 305 ttt tca gag cag cgg cag agc aaa cat agg cgc ttt cag aat acc cta 1017 Phe Ser Glu Gln Arg Gln Ser Lys His Arg Arg Phe Gln Asn Thr Leu 310 315 320 gta gtc cta cat aaa tct ggt ttg ct g gag atc act ttg aaa acc aag 1065 Val Val Leu His Lys Ser Gly Leu Leu Glu Ile Thr Leu Lys Thr Lys 325 330 335 gag ttg att cgt cag aat cag gca act cag gta gaa cta gac cag cta 1113 Glu Leu Ile Arg Gln Asn Gln Ala Thr Gln Val Glu Leu Asp Gln Leu 340 345 350 aag gag caa acc cag ctg ttt ata gaa gcc acc aag agc agg gcc cct 1161 Lys Glu Gln Thr Gln Leu Phe Ile Glu Ala Thr Lys Ser Arg Ala Pro 355 360 365 370 cag gct tgg gcc aag ctg cag gca tct tta aca cct ggg tcc agt aat 1209 Gln Ala Trp Ala Lys Leu Gln Ala Ser Leu Thr Pro Gly Ser Ser Asn 375 380 385 aca ggc agt gac cta gaa gca ttc tct gat cac g ata 1251 Thr Gly Ser Asp Leu Glu Ala Phe Ser Asp His Pro Ala Ile 390 395 400 tagcacagag gcatattttc ctgttacttg agtggttctt ttagctcatt tgctgttacc 1311 tactcctgtt tcccaaagct tatgtaagag cttttccttc taaacttaaa ctgtgttgtg 1371 gttcacttag gaagccacgt gccaatacct ggctgctgtc ttaactcgta gtctgggcac 1431 aggatacata tgtccccgtc ccactgagga cctcagtttg ggagtgccct tgagcccctt 1491 ttccttagcc tgcaggtgct tcaatggatc atgg ggcaaa gcaggagatg attgtgtggg 1551 gctcttcctg ctgtcacctc ccatcatccc actctctcac caggatcaag ggtacagtaa 1611 cacgaatgag catacagagc aacgcctgtt gagccaggga gtaggtgaca caaggaaacc 1671 ttcatggatc ttcccttgcc tgtcttagtc acagagagaa ataagaggag gttgtttgca 1731 tcccacaagg catcgtacta gttgggcgag acctaaaatt ccctgggcac aggttgcacc 1791 tgggtgtgag cacttaatca ctcaacgctt tgttttctta cacttgaaaa tcaagggaaa 1851 gactagtacc atctgactcc tacactttca ttacaagtca gatttttctt aaactagcag 1911 gcaaaaacag tacttccaaa ttttaaggta tggaatgaat gcagtacatc tggaattgta 1971 gtcgatgaat tgcttttttg acttagaagc tgaagaaaat agacatagcc ggcatatctc 2031 atggtcagga gctggacgat tctggtaact taggcttttt ttctctcttc ttttgaaaca 2091 gtgtaacctg ttttatgtct aaatatctta aggatagttt cagtggttcc tgggatgtag 2151 tataagttaa ctctgctgcc atcttgtttt tttttttttc ctttattttg ataagtgatt 2211 attatgcttg ataaactttg aattaaatac agttgtcttg agggtatgat aagtccacaa 2271 aaaattggaa agcatcttac ccattttctt cacatcccaa atttttattt gttccatgtc 2331 atagtgatgg gaagcagtta cagagcagcg tcttctgtg t ttccttcatg tgttagatat 2391 tggcaacaaa gccagaggtg taatgttggt tatatgaagt tcatctcaaa atggagacca 2451 tgaccagagt ttccagatga tacacgttct tttcagcttc attaaatagg caactatgtt 2511 tctaaatagt aaagtttcaa aatattctct caatttaaaa tttcatcctc ttgaaaatct 2571 ttgttcttta caaaattatc ttaataagtt ctatatggtc agcttcatct tccttttttt 2631 tttttttgag atggagtttc gctcttgttg cccaggcgga gtacaatggt gggatctcgg 2691 ctcactgcaa cctccgcctc ctgggttcaa gtgattctcc tgccacagcc tcccaagtag 2751 ctgggattac aggtgcctgc caccatgccc agctaatttt tgtattttta gtagaaatgg 2811 ggttttaccg tgttggccag gctggtctcg aactcctgac ctcagttgat ccgcctgcct 2871 cagcctccca aagtgctggg cttacaggcc tgagccacca cgctcagctc agcttcaccc 2931 tgtctgcaaa gaaaagtttt accaagacca gaagtgaaat atgacatttc ctaggtagtt 2991 gtaactctaa catagtttaa aaagtatgtg gcttcagatt gcctatactt tgttcacaaa 3051 cgtgtgattt agatatgact gatttagaag tgaacaactt ggtaacatcc ctagactcca 3111 ctcatgaacg cagaattatt acctgctgtt tgctttctga aagaatttca gaaatcagag 3171 caaatgtgtc tttaggcaga ttcagctcct tttaatattt ttc tcttggc ccactctctt 3231 tgcctcccct gaatctgtgt ggtactatag cagctctact ctgtgcacca tgctaggaag 3291 cttccttttt ggcagaatat gtttggcagc aaagctatag agacaggtgc attcagaaca 3351 tcctgggcac cagtcatgag tcttactgtg tcaaaaatct gaaaacactt gctgagaacc 3411 aaatttattc cattggaaaa accctctgtg gagctataag cctcttggac tcttcttcct 3471 agattaaggc ttgcatttcc ctccctgttt cagtaaaaga tgatgaaagc cactatcaat 3531 cctcactgct gagtggcagg gagaagcagc accactctca gctcttttct aatcttgtaa 3591 cttagtgcta gaagtctctc caggctatta ccatgggcat ttgttctctg ttggagctgt 3651 aagcagatga acccaagtag agaagataga tcttggaagg agagatccat tgagtccaga 3711 agccagatca gcaaatggag gaacctcgga ggtgaccaga aagatctcca tcggttgccc 3771 aaggctgtaa gtagtgatgg ttttagcgat gaataacgta attggctatg aagtactgtg 3831 gcagagctgc tgttttctga aggtgagaag ccatttttag ctcagagcaa cccttaagag 3891 aacttttggc agattttgtt ggcattattg aaatatatat agaaaagttg ctgattgcaa 3951 tggttatggg aatggaattt aatgacattt gtaatttatt acactcattg gtttttattg 4011 attatagtat tgtctgactt tttattttct actatggttc ctttagcag a aaagtaactt 4071 ttgtgcatat attgaagtgg tttttcagct atgaattctt tagggtagaa atttatttag 4131 caaatgtgaa ttcttttgag aaagtatgaa gttttgcaga aattgactgt gaaatgtcag 4191 agaaaaataa aagtcactta cttgaaacct <210> 216 <211> 4079 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2546) <400> 216 aa gtg ccc gaa atg gag gct aaa att gaa gat act aaa cga cgc ctt 47 Val Pro Glu Met Glu Ala Lys Ile Glu Asp Thr Lys Arg Arg Leu 1 5 10 15 tca gaa gtc atc tat gag cct ttt cag ctc ctt agt aaa att ata ggg 95 Ser Glu Val Ile Tyr Glu Pro Phe Gln Leu Leu Ser Lys Ile Ile Gly 20 25 30 gaa gaa agt ggc agc cat agg ccc aaa gcc tta tct tca agt gct tca 143 Glu Glu Ser Gly Ser His Arg Pro Lys Ala Leu Ser Ser Ser Ala Ser 35 40 45 gaa ctc tcc aat ctg tcc agc ttg aat ggg cac ttg gaa agc aat aac 191 Glu Leu Ser Asn Leu Ser Ser Leu Asn Gly His Leu Glu Ser Asn Asn 50 55 60 aac tac agc atc aag gag gag gag tgt gat tct gag ggg gat ggc tac 239 Asn Tyr Ser Ile Lys Glu Glu Glu Cys Asp Ser Glu Gly Asp Gly Tyr 65 70 75 gga agt gat tcc aac atc ccc aga agt gac cac cca aag tcc act ggt 287 Gly Ser Asp Ser Asn Ile Pro Arg Ser Asp His Pro Lys Ser Thr Gly 80 85 90 95 gag ccc aca aga gag ata gaa ctg aaa agt tcc cag ggg agc agt ctg 335 Glu Pro Thr Arg Glu Ile Glu Leu Lys Ser Ser Gln Gly Ser Ser Leu 100 105 110 aa g gat tta ggc ctg aag aca agt tct cta gtt ctg gag aaa tgt tct 383 Lys Asp Leu Gly Leu Lys Thr Ser Ser Leu Val Leu Glu Lys Cys Ser 115 120 125 ttg tct gcc tta gtg agc aaa gaa gat gaa gag ttt tgt ctg tac 431 Leu Ser Ala Leu Val Ser Lys Glu Asp Glu Glu Phe Cys Glu Leu Tyr 130 135 140 act gag gac ttc gat ttg gaa acg gag ggg gag agt aaa gtt gat aag 479 Thr Glu Asp Phe Asp Leu Glu Thr Glu Gly Glu Ser Lys Val Asp Lys 145 150 155 ctc tca gat att cct ctc aag cca gag gtg ctc gcg gaa gat ggt gtg 527 Leu Ser Asp Ile Pro Leu Lys Pro Glu Val Leu Ala Glu Asp Gly Val 160 165 170 175 gtc ctt gag gag gac gag gtg gac tcg gcc gtg cag cac ccg gaa 575 Val Leu Asp Ser Glu Asp Glu Val Asp Ser Ala Val Gln His Pro Glu 180 185 190 ttg cca gtg aag acg ttg ggc ttc ttt ata atg tgt gtc tat gtg tac Val Lys Thr Leu Gly Phe Phe Ile Met Cys Val Tyr Val Tyr 195 200 205 ctc atc ctc ccc ctc ccc cac tat gtg agt gga ctc ttt ctg gga att 671 Leu Ile Leu Pro Leu Pro His Tyr Val Ser Gly Leu Phe Leu Gly Ile Two 10 215 220 ggc ctt gga ttc atg act gca gtt tgc gtg att tgg ttt ttt aca cca 719 Gly Leu Gly Phe Met Thr Ala Val Cys Val Ile Trp Phe Phe Thr Pro 225 230 235 cca agt gct cat aaa tat cac aag tta cac aaa aat ctg cga cac tgg 767 Pro Ser Ala His Lys Tyr His Lys Leu His Lys Asn Leu Arg His Trp 240 245 250 255 aac aca aga tct ctg gat atc aaa gaa cct gaa ata ctg aag gga tgg 815 Asn Thr Arg Ser Leu Asp Ile Lys Glu Pro Glu Ile Leu Lys Gly Trp 260 265 270 atg aat gag att tac aac tat gat cca gaa acc tac cat gcg act ttg 863 Met Asn Glu Ile Tyr Asn Tyr Asp Pro Glu Thr Tyr His Ala Thr Leu 275 280 285 aca cat tca gtc ttt gtt cga ctt gag ggt gga acc tta aga ctt tca 911 Thr His Ser Val Phe Val Arg Leu Glu Gly Gly Thr Leu Arg Leu Ser 290 295 300 aag ccc aat aaa aat ata tcc agg agg gcc agc tac aat gaa ccc aag 959 Lys Pro Asn Lys Asn Ile Ser Arg Arg Ala Ser Tyr Asn Glu Pro Lys 305 310 315 cca gag gtc acc tac atc agc cag aaa atc tat gac ctc tca gac agc 1007 Pro Glu Val Thr Tyr Ile Ser Gln Lys Ile Tyr Asp LeuSer Asp Ser 320 325 330 335 aag att tat ctt gta cct aaa act ttg gct cga aag cga atc tgg aat 1055 Lys Ile Tyr Leu Val Pro Lys Thr Leu Ala Arg Lys Arg Ile Trp Asn 340 345 350 350 aaa aag tac ccc att tgt atc gag ctt ggt cag caa gat gac ttt atg 1103 Lys Lys Tyr Pro Ile Cys Ile Glu Leu Gly Gln Gln Asp Asp Phe Met 355 360 365 tct aaa gct cag act gat aag gag act tca gaa gag aag ccg cca gct 1151 Ser Lys Ala Gln Thr Asp Lys Glu Thr Ser Glu Glu Lys Pro Pro Ala 370 375 380 gag gga agt gag gac cct aag aag cca ccc cgc cct cag gag gga aca 1199 Glu Gly Ser Glu Asp Pro Lys Lys Pro Pro Arg Pro Gln Glu Gly Thr 385 390 395 aga tct agc cag cga gat cag ata ctc tat ctc ttt ggg aga act ggc 1247 Arg Ser Ser Gln Arg Asp Gln Ile Leu Tyr Leu Phe Gly Arg Thr Gly 400 405 410 415 cga gaa aaa gag gaa tgg ttt agg gatt att gca tct aag cta 1295 Arg Glu Lys Glu Glu Trp Phe Arg Arg Phe Ile Leu Ala Ser Lys Leu 420 425 430 aag tcg gaa atc aag aag tca tcg ggt gtc tct gga ggt aaa cca ggg 1343 Lys Ser Glu Ile Lys Lys Ser Ser Gly Val Ser Gly Gly Lys Pro Gly 435 440 445 ctt ttg cct gca cac agc aga cac aac agt ccg tcc ggg cac ctg acc 1391 Leu Leu Pro Ala His Ser Arg His Asn Ser Pro Ser Gly His Leu Thr 450 455 460 cac agc cgc agc agc agc aaa ggc agt gtg gag gag atc atg tca cag 1439 His Ser Arg Ser Ser Ser Lys Gly Ser Val Glu Glu Ile Met Ser Gln 465 470 475 cca aag cag aag gag ctg gca ggc agc gtg cgg cgg ag atg 1487 Pro Lys Gln Lys Glu Leu Ala Gly Ser Val Arg Gln Lys Met Leu Leu 480 485 490 495 gac tac agc gtg tac atg ggc agg tgt gtc ccc cag gaa agc cga agc 1535 Asp Tyr Ser Val Tyr Met Gly Arg Cys Val Glu Ser Arg Ser 500 505 510 ccc cag agg agc ccc ctg cag agt gcg gag agc agc ccc aca gct ggg 1583 Pro Gln Arg Ser Pro Leu Gln Ser Ala Glu Ser Ser Pro Thr Ala Gly 515 520 525 aag aag ttg cca gag gtt cca ccc tct gag gag gaa gaa cag gaa gcc 1631 Lys Lys Leu Pro Glu Val Pro Pro Ser Glu Glu Glu Glu Gln Glu Ala 530 535 540 tgg gtg aat gcc ttg ctt gga aga ata ttt tgg gac ttc tta gga gag 1679 Trp Val sn Ala Leu Leu Gly Arg Ile Phe Trp Asp Phe Leu Gly Glu 545 550 555 aaa tac tgg tct gat ctg gtg tct aag aag atc caa atg aaa ctc agc 1727 Lys Tyr Trp Ser Asp Leu Val Ser Lys Lys Ile Gln Met Lys Le 560 565 570 575 aaa ata aag ctc ccc tac ttt atg aat gag ctc act ctg acg gaa ctt 1775 Lys Ile Lys Leu Pro Tyr Phe Met Asn Glu Leu Thr Leu Thr Glu Leu 580 585 590 gac atg ggc gtg cct gtcca cag gcc ttc aag cct tac 1823 Asp Met Gly Val Ala Val Pro Lys Ile Leu Gln Ala Phe Lys Pro Tyr 595 600 605 gtt gat cac caa gga ctc tgg att gat ttg gaa atg tcc tac aat ggg 1871 Val Asp His Gln Gly Leu Trp Ile Asp Leu Glu Met Ser Tyr Asn Gly 610 615 620 tcc ttt ctg atg act ctc gag acc aaa atg aat ttg acc aaa cta ggt 1919 Ser Phe Leu Met Thr Leu Glu Thr Lys Met Asn Leu Thr Lys Leu Gly 625 630 630 635 aaa gag cct ctt gtt gaa gcc ctg aag gtt gga gaa att ggc aaa gaa 1967 Lys Glu Pro Leu Val Glu Ala Leu Lys Val Gly Glu Ile Gly Lys Glu 640 645 650 650 655 ggt tgc agg ccc cgg gca ttc tgt ctg gcgac gc g gaa tcc 2015 Gly Cys Arg Pro Arg Ala Phe Cys Leu Ala Asp Ser Asp Glu Glu Ser 660 665 670 tcc agc gct ggc tcc tcc gag gaa gac gat gcc cca gag ccc agc ggg 2063 Ser Ser Ala Gly Ser Ser Glu Glu Asp Asp Ala Pro Glu Pro Ser Gly 675 680 685 gga gac aaa cag ctc ctc cca ggg gct gaa ggg tac gtt gga ggt cat 2111 Gly Asp Lys Gln Leu Leu Pro Gly Ala Glu Gly Tyr Val Gly Gly His 690 695 700 cga aca agt aag att atg agg ttt gtt gat aaa att acc aag tca aaa 2159 Arg Thr Ser Lys Ile Met Arg Phe Val Asp Lys Ile Thr Lys Ser Lys 705 710 710 715 tat ttc caa aaa gca aca gag aca gag ttt att aaa aag aag aag atc gaa 2207 Tyr Phe Gln Lys Ala Thr Glu Thr Glu Phe Ile Lys Lys Lys Ile Glu 720 725 730 735 gaa gtc tcc aac aca ccc ctg ctg ctc act gtt gaa gta caa gaa tgt 2255 Glu Val Ser Asn Thr Pro Leu Leu Leu Thr Val Glu Val Gln Glu Cys 740 745 750 aga gga acc ttg gcg gtc aac att cca cca ccc ccg act gac cga gta 2303 Arg Gly Thr Leu Ala Val Asn Ile Pro Pro Pro Pro Thr Asp Arg Val 755 760 765 tgg tat ggt ttc cga aag cca cca cat gtg gag ctg aaa gct cgg cca 2351 Trp Tyr Gly Phe Arg Lys Pro Pro His Val Glu Leu Lys Ala Arg Pro 770 775 780 aaa ctt gga gag aga gaa gtg act tta gtt cat gtg aca gac tgg ata 2399 Lys Leu Gly Glu Glu Glu Glu Val Thr Leu Val His Val Thr Asp Trp Ile 785 790 795 gag aag aaa ctg gag caa gag ttt cag aaa gtt ttt gtc atg cca aac 2447 Glu Lys Lys Leu Glu Gln Glu Phe Gln Lys Val Phe Val Met Pro Asn 800 805 810 810 815 815 atg gat gat gtt tat atc act ata atg cac tca gcc atg gac cct cgc 2495 Met Asp Asp Val Tyr Ile Thr Ile Met His Ser Ala Met Asp Pro Arg 820 825 830 tct act tcc tgc ctc ctg aaa gac cca cct gtg gag gct gat cag 2543 Ser Thr Ser Cys Leu Leu Lys Asp Pro Pro Val Glu Ala Ala Asp Gln 835 840 845 cca tgatgggtga tgtcagatgt tccccatatt gtgacatcga gctggatgtg 2596 Pro tggggttctt ggccgccatc tgtactgtag cactggcctc tgtgccacag ctactgtttc 2656 ttaaaggact gcttctgccc tctgcctgcc agtgcccatt ccactgtgag gtgtcattcc 2716 ctgcatctag tgacaactgt ctggattgcc tgctgcaaag ctttgatttg gcaaaggaga 2776 ccatggaaga atcatggtgg at ccagaagt tatacgtgac ccacaccatg gcttttaaaa 2836 gtctacccat gtttgtggca gcaaatgagc acagtaagag caaagctgaa caacttgcct 2896 cctctactcc tccaaagctt ttcttcaggc agccggtgca cagtggactt tttcacttct 2956 atactttgta tgcggccttc cacacttcca gagaatgtca gtgtgcaatg tgtctggagg 3016 gtggggagag gaattctgtg agccttttca tttcggtgac agaagagatg ggcagagcaa 3076 cttattttcc acattaaatt gtgcatttgg gaagcaagta gccatagtac acacacaaca 3136 cgctatcagc ttgggtaagg acagtgggat ttatgtgaac atcaggcaaa gccatgagat 3196 caaaccatcc caagcctttc accaatgagg tacaaccacc tgggggctag ctaatcttga 3256 atgttttcct gagacaggag cgtatgtgaa aacatcaaac actgcacatg acaggatggg 3316 tcctctcata cagatgggat ggggttagaa agccagagcc agtttttcca tctggcgttt 3376 cctgtgtcct ccaggtttat atgggaatcg aaacagtttg ttaatctgat tgggagagtt 3436 ccatgggcag atttcccttc ctgaaggcca aaacggagaa ctgctctctt taattatttc 3496 aagagtcaag accaaaagtt tgctcagcat cacactacat ctcaaaatta atgttgccaa 3556 cttaattttg tgcatttgtg tcagaatgtt tagtttacaa ggttgggggc tctctttgct 3616 tcgagaagta aacctaatac catttttt ta ttgtttaaag ctgcattcaa cgtcaaaatt 3676 accttgggta acttttgata acttacatgt gtggacaaag ctaatagtgg ttttttaaac 3736 agcaccttgc ctgaacatga ctttaaagaa attaatatat tgaaaacatg tttgaaccct 3796 tattttaatt gcaccattaa aacatttgac ttaaattgtt tgaccattcc agttggtgta 3856 ctgttctgat ttttcgttgt gtaggccgat ctgcctgtca gagtccacgt gtcctggtca 3916 ctggtcttta taattgttgt gcaataacta aaggctaagg actagatgca ctatcgtgta 3976 aagagattac acatgactgt accatgttgc acttaatcaa atagtatgtg gggatttaaa 4036 atcgcttgca ttgtttcaca aaataaatat ctcaatgtca aat 4079 <210> 217 <211> 3776 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (232) .. (2889) <400> 217 ctgtgctcgc atctctggca gcctggattg gggtcctgct ggagtgaagg gtttcctgag 60 gcagggagta ctcatagccg tctgtgcctc ctgctctgct ggactctgat agaggcagtg 120 ggcagcaggg caaagaagga agcagccgcc gaggaagcga aggtggggtg ggggtgccca 180 gccctgcggc cggaggtgcc attgaccctg agagcaagag ccatcagtct g atg gct 237 Met Ala 1 tcc tct ggc cgg aag ctg tgg ctg aga tat cct tcc ttc ctc cca gca 285 Ser Ser Gly Arg Lys Leu Trp Leu Arg Tyr Pro Ser Phe Leu Pro Ala 5 10 15 gcc tgg att tgc ctc ctc cca ggc tgg gaa agg cta ggg agg ccc agg 333 Ala Trp Ile Cys Leu Leu Pro Gly Trp Glu Arg Leu Gly Arg Pro Arg 20 25 30 tgg ggc tgt cag ggc caa agg ctg ttt caa aag tgt cct tta ttg cca 381 Trp Gly Cys Gln Gly Gln Arg Leu Phe Gln Lys Cys Pro Leu Leu Pro 35 40 45 50 atc agg ggg ttt ggc tgg cat ctg ctt gtg gca tgg ggt gct ggc tct 429 Ile Arg Gly Phe Gly Trp His Leu Leu Val Ala Trp Gly Ala Gly Ser 55 60 65 cgt gga gca aga ctg agg gct gtc gag ccc cag ggg tcc tgc cca tca 477 Gly Ala Arg Leu Arg Ala Val Glu Pro Gln Gly Ser Cys Pro Ser 70 75 80 gca gcc atg ctt acc cct gca gag ctg gcc acg gta gta cgg cgg ttc 525 Ala Ala Met Leu Thr Pro Ala Glu Leu Ala Thr Val Val Arg Arg Phe 85 90 95 tcc cag acc ggc atc cag gac ttc ctg aca ctg acg ctg acg gag ccc 573 Ser Gln Thr Gly Ile Gln Asp Phe Leu Thr Leu Thr Leu Thr Glu Pro 100 105 110 act ggg ctt ctg tac gtg ggc gcc cga gag gcc ctg ttt gcc ttc agc 621 Thr Gly Leu Leu Tyr Val Gly Ala Arg Glu Ala Leu Phe Ala Phe Ser 115 120 125 130 atg gag gcc ctg gag ctg caa gga gcg atc tcc tgg gag gcc ccc gtg 669 Met Glu Ala Leu Glu Leu Gln Gly Ala Ile Ser Trp Glu Ala Pro Val 135 140 145 gag aag aag act gag tgt atc cag aaa ggg aag aac aac cag acc gag 717 Glu Lys Lys Thr Glu Cys Ile Gln Lys Gly Lys Asn Asn Gln Thr Glu 150 155 160 tgc ttc aac ttc atc cgc ttc ctg cag ccc tac aat gcc tcc cac cc Cys Phe Asn Phe Ile Arg Phe Leu Gln Pro Tyr Asn Ala Ser His Leu 165 170 175 tac gtc tgt ggc acc tac gcc ttc cag ccc aag tgc acc tac gtc aac 813 Tyr Val Cys Gly Thr Tyr Ala Phe Gln Pro Lys Cys Thr Tyr Val A sn 180 185 190 atg ctc acc ttc act ttg gag cat gga gag ttt gaa gat ggg aag ggc 861 Met Leu Thr Phe Thr Leu Glu His Gly Glu Phe Glu Asp Gly Lys Gly 195 200 205 210 aag tgt ccc tat gac cca gct aag ggc cat gct ggc ctt ctt gtg gat 909 Lys Cys Pro Tyr Asp Pro Ala Lys Gly His Ala Gly Leu Leu Val Asp 215 220 225 ggt gag ctg tac tcg gcc aca ctc aac aac ttc ctg ggc acg gaa ccc 957 Gly Alu Leu Thr Leu Asn Asn Phe Leu Gly Thr Glu Pro 230 235 240 att atc ctg cgt aac atg ggg ccc cac cac tcc atg aag aca gag tac 1005 Ile Ile Leu Arg Asn Met Gly Pro His His Ser Met Lys Thr Glu Tyr 245 250 255 ctg gcc ttt tgg ctc aac gaa cct cac ttt gta ggc tct gcc tat gta 1053 Leu Ala Phe Trp Leu Asn Glu Pro His Phe Val Gly Ser Ala Tyr Val 260 265 270 cct gag agt gtg ggc agc ttc acg ggg gac gac gac agag ttc 1101 Pro Glu Ser Val Gly Ser Phe Thr Gly Asp Asp Asp Lys Val Tyr Phe 275 280 285 290 ttc ttc agg gag cgg gca gtg gag tcc gac tgc tat gcc gag cag gtg 1149 Phe Phe Arg Glu Arg Ala Val Glu Ser Asp ys Tyr Ala Glu Gln Val 295 300 305 gtg gct cgt gtg gcc cgt gtc tgc aag ggc gat atg ggg ggc gca cgg 1197 Val Ala Arg Val Ala Arg Val Cys Lys Gly Asp Met Gly Gly Ala Arg 310 315 320 acc ctg cag agg tgg acc acg ttc ctg aag gcg cgg ctg gca tgc 1245 Thr Leu Gln Arg Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ala Cys 325 330 335 tct gcc ccg aac tgg cag ctc tac ttc aac cag ctg cag gc atg ag cg Ag cg ag cg ag cg atg ag cg atg Pro Asn Trp Gln Leu Tyr Phe Asn Gln Leu Gln Ala Met His 340 345 350 acc ctg cag gac acc tcc tgg cac aac acc acc ttc ttt ggg gtt ttt 1341 Thr Leu Gln Asp Thr Ser Trp His Asn Thr Thr Phe Phe Gly Val Phe 355 360 365 370 caa gca cag tgg ggt gac atg tac ctg tcg gcc atc tgt gag tac cag 1389 Gln Ala Gln Trp Gly Asp Met Tyr Leu Ser Ala Ile Cys Glu Tyr Gln 375 380 385 ttg gaa gag atc cag cgg gtg ttt ccc tat aag gag tac cat 1437 Leu Glu Glu Ile Gln Arg Val Phe Glu Gly Pro Tyr Lys Glu Tyr His 390 395 400 gag gaa gcc cag aag tgg gac cgc tac act gac cct gta ccc agc cct 1485 Glu Glu Ala Gln Lys Tr p Asp Arg Tyr Thr Asp Pro Val Pro Ser Pro 405 410 415 cgg cct ggc tcg tgc att aac aac tgg cat cgg cgc cac ggc tac acc 1533 Arg Pro Gly Ser Cys Ile Asn Asn Trp His Arg Arg His Gly Tyr Thr 420 425 430 agc tcc ctg gag cta ccc gac aac atc ctc aac ttc gtc aag aag cac 1581 Ser Ser Leu Glu Leu Pro Asp Asn Ile Leu Asn Phe Val Lys Lys His 435 440 445 450 ccg ctg atg gag gag cag gtg ggg cg cgg tgg ccc ctg ctc 1629 Pro Leu Met Glu Glu Gln Val Gly Pro Arg Trp Ser Arg Pro Leu Leu 455 460 465 gtg aag aag ggc acc aac ttc acc cac ctg gtg gcc gac cgg gtt aca 1677 Val Lys Lys Gly Thr Asn Phe Thr His Leu Val Ala Asp Arg Val Thr 470 475 480 gga ctt gat gga gcc acc tat aca gtg ctg ttc att ggc aca gga gac 1725 Gly Leu Asp Gly Ala Thr Tyr Thr Val Leu Phe Ile Gly Thr Gly Asp 485 490 495 ggc tgg ctg ctc gct gtg agc ctg ggg ccc tgg gtt cac ctg att 1773 Gly Trp Leu Leu Lys Ala Val Ser Leu Gly Pro Trp Val His Leu Ile 500 505 510 gag gag ctg cag ctg ttt gac cag gag ccc atg aga agc ctg gtg c18 u Glu Leu Gln Leu Phe Asp Gln Glu Pro Met Arg Ser Leu Val Leu 515 520 525 530 tct cag agc aag aag ctg ctc ttt gcc ggc tcc cgc tct cag ctg gtg 1869 Ser Gln Ser Lys Lys Leu Leu Phe Ala Gly Ser Ar Gln Leu Val 535 540 545 cag ctg ccc gtg gcc gac tgc atg aag tat cgc tcc tgt gca gac tgt 1917 Gln Leu Pro Val Ala Asp Cys Met Lys Tyr Arg Ser Cys Ala Asp Cys 550 555 550 560 gtc ctc gcc cgg gccc gcc tgg agc gtc aac acc agc cgc 1965 Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Val Asn Thr Ser Arg 565 570 575 tgt gtg gcc gtg ggt ggc cac tct gga tct cta ctg atc cag cat gtg 2013 Cys Val Ala Vally Gly His Ser Gly Ser Leu Leu Ile Gln His Val 580 585 590 atg acc tcg gac act tca ggc atc tgc aac ctc cgt ggc agt aag aaa 2061 Met Thr Ser Asp Thr Ser Gly Ile Cys Asn Leu Arg Gly Ser Lys Lys 595 600 605 610 gtc agg ccc act ccc aaa aac atc acg gtg gtg gcg ggc aca gac ctg 2109 Val Arg Pro Thr Pro Lys Asn Ile Thr Val Val Ala Gly Thr Asp Leu 615 620 625 gtg ctg ccc tgc cac ctc tcc tcc aac ttg gcc cgc tgg acc 2157 Val Leu Pro Cys His Leu Ser Ser Asn Leu Ala His Ala Arg Trp Thr 630 635 640 ttt ggg ggc cgg gac ctg cct gcg gaa cag ccc ggg tcc ttc ctc tac 2205 Phe Gly Gly Arg Asp Leu Pro Ala Gln Pro Gly Ser Phe Leu Tyr 645 650 655 gat gcc cgg ctc cag gcc ctg gtt gtg atg gct gcc cag ccc cgc cat 2253 Asp Ala Arg Leu Gln Ala Leu Val Val Met Ala Ala Gln Pro Arg His 660 665 670 gcc ggg gcc tac cac tgc ttt tca gag gag cag ggg gcg cgg ctg gct 2301 Ala Gly Ala Tyr His Cys Phe Ser Glu Glu Gln Gly Ala Arg Leu Ala 675 680 685 690 gct gaa ggc tac ctt gtg gct gtc gtg gca ggc gc ccg Ala Glu Gly Tyr Leu Val Ala Val Val Ala Gly Pro Ser Val Thr Leu 695 700 705 gag gct cgg gcc ccc ctg gaa aac ctg ggg ctg gtg tgg ctg gcg gtg 2397 Glu Ala Arg Ala Pro Leu Glu Asn Leu Gly Leu Val Trp Ala Val 710 715 720 gtg gcc ctg ggg gct gtg tgc ctg gtg ctg ctg ctg ctg gtg ctg tca 2445 Val Ala Leu Gly Ala Val Cys Leu Val Leu Leu Leu Leu Val Leu Ser 725 730 735 ttg cgc cgg cgg cgg cgg ag ctg gag aaa ggg gcc aag gct act 2493 Leu Arg Arg Arg Leu Arg Glu Glu Leu Glu Lys Gly Ala Lys Ala Thr 740 745 750 gag agg acc ttg gtg tac ccc ctg gag ctg ccc aag gag ccc acc agt Thr 4141 Glu Arg Val Tyr Pro Leu Glu Leu Pro Lys Glu Pro Thr Ser 755 760 765 770 ccc ccc ttc cgg ccc tgt cct gaa cca gat gag aaa ctt tgg gat cct 2589 Pro Pro Phe Arg Pro Cys Pro Glu Pro Asp Glu Lys Leu Trp Asp Pro 775 780 785 gtc ggt tac tac tat tca gat ggc tcc ctt aag ata gta cct ggg cat 2637 Val Gly Tyr Tyr Tyr Ser Asp Gly Ser Leu Lys Ile Val Pro Gly His 790 795 800 gcc cgg tgc cag ccc ggt ggg ggg ccc cct tcg cca cct cca ggc atc 2685 Ala Arg Cys Gln Pro Gly Gly Gly Pro Pro Ser Pro Pro Pro Gly Ile 805 810 815 cca ggc cag cct ctg cct tct cca act cgg ctt cac ctg ggg ggt ggg 2733 Pro Gly Gln Pro Leu Pro Ser Pro Thr Arg Leu His Leu Gly Gly Gly 820 825 830 cgg aac tca aat gcc aat ggt tac gtg cgc tta caa cta gga ggg gag 2781 Arg Asn Ser Asn Ala Asn Gly Tyr Val Arg Leu Gln Leu Gly Gly Glu 835 840 845 850 gacg g gga ggg ctc ggg cac ccc ctg cct gag ctc gcg gat gaa ctg 2829 Asp Arg Gly Gly Leu Gly His Pro Leu Pro Glu Leu Ala Asp Glu Leu 855 860 865 aga cgc aaa ctg cag caa cgc cag cca ccg ccc ccc gcc gag 2877 Arg Arg Lys Leu Gln Gln Arg Gln Pro Leu Pro Asp Ser Asn Pro Glu 870 875 880 gag tca tca gta tgaggggaac ccccaccgcg tcggcgggaa gcgtgggagg 2929 Glu Ser Ser Val 885 tgtagctcct acttttgcac aggcaccagc tacctcaggg acatggcacg ggcacctgct 2989 ctgtctggga cagatactgc ccagcaccca cccggccatg aggacctgct ctgctcagca 3049 cgggcactgc cacttggtgt ggctcaccag ggcaccagcc tcgcagaagg catcttcctc 3109 ctctctgtga atcacagaca cgcgggaccc cagccgccaa aacttttcaa ggcagaagtt 3169 tcaagatgtg tgtttgtctg tatttgcaca tgtgtttgtg tgtgtgtgta tgtgtgtgtg 3229 cacgcgcgtg cgcgcttgtg gcatagcctt cctgtttctg tcaagtcttc ccttggcctg 3289 ggtcctcctg gtgagtcatt ggagctatga aggggaaggg gtcgtatcac tttgtctctc 3349 ctacccccac tgccccgagt gtcgggcagc gatgtacata tggaggtggg gtggacaggg 3409 tgctgtgccc cttcagaggg agtgcagggc ttggggtggg cctagtcctg ctcctag ggc 3469 tgtgaatgtt ttcagggtgg ggggagggag atggagcctc ctgtgtgttt ggggggaagg 3529 gtgggtgggg cctcccactt ggccccgggg ttcagtggta ttttatactt gccttcttcc 3589 tgtacagggc tgggaaaggc tgtgtgaggg gagagaaggg agagggtggg cctgctgtgg 3649 acaatggcat actctcttcc agccctagga ggagggctcc taacagtgta acttattgtg 3709 tccccgcgta tttatttgtt gtaaatattt gagtattttt atattgacaa ataaaatgga 3769 gaaaatg 3776 <210> 218 <211> 3837 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (3359) <400> 218 ag aag aag gag cag gag cag atg cta aag gaa gag agg aaa cgc gag 47 Lys Lys Glu Gln Glu Gln Met Leu Lys Glu Glu Glu Arg Lys Arg Glu 1 5 10 15 ttg gag gag aag gtc aag gca gat gga gat cga gcg aag agg aga aag 95 Leu Glu Glu Lys Val Lys Ala Val Glu Asp Arg Ala Lys Arg Arg Lys 20 25 30 ctc agg gaa gaa agg gca tgg ctg ctg gct caa gga aag gag ctc cct 143 Leu Arg Glu Ag Leu Leu Ala Gln Gly Lys Glu Leu Pro 35 40 45 cca gaa ctt tcc cat ctg gac ccc aat tcc ccc atg aga gag gaa aaa 191 Pro Glu Leu Ser His Leu Asp Pro Asn Ser Pro Met Arg Glu Glu Lys 50 55 60 aag act aaa gac ctc ttt gag ttg gat gat gat ttc act gct atg tat 239 Lys Thr Lys Asp Leu Phe Glu Leu Asp Asp Asp Phe Thr Ala Met Tyr 65 70 75 aaa gtt cta gac gtg gta aag gct cac aag gat tcc gg ccc ttc 287 Lys Val Leu Asp Val Val Lys Ala His Lys Asp Ser Trp Pro Phe Leu 80 85 90 95 gaa cct gtg gat gaa tct tat gcc cct aac tat tat cag att att aag 335 Glu Pro Val Asp Glu Ser Tyr Ala Pro Asn Tyr Tyr Gln Ile Ile Lys 100 105 110 gcc ccc atg gat att tcc agc atg gag aag aaa ctg aat gga ggt tta 383 Ala Pro Met Asp Ile Ser Ser Met Glu Lys Lys Leu Asn Gly Gly Leu 115 120 125 tac tgt acc aag gag gaa ttt gta aat gac atg aag acc atg ttc agg 431 Tyr Cys Thr Lys Glu Glu Phe Val Asn Asp Met Lys Thr Met Phe Arg 130 135 140 aat tgt cga aag tat aat ggg gaagt agt gag tat acc aag atg tct 479 Asn Cys Arg Lys Tyr Asn Gly Glu Ser Ser Glu Tyr Thr Lys Met Ser 145 150 155 gat aat tta gag agg tgt ttc cat cgg gca atg atg aaa cat ttt cct 527 Asp Asn Leu Glu Arg Cys Phe His Arg Ala Met Met Lys His Phe Pro 160 165 170 170 175 gga gaa gat gga gac aca gat gaa gaa ttt tgg att cga gag gat gaa 575 Gly Glu Asp Gly Asp Thr Asp Glu Glu Phe Trp Ile Arg Glu Asp Glu 180 185 190 aag cgg gag aaa aga cgg agt cgg gct ggg cga agt ggt ggg agc cat 623 Lys Lys Arg Arg Ser Arg Ala Gly Arg Ser Gly Gly Ser His 195 200 205 gtt tgg acc cgc tcc agg gac cca gaa ggg tcc agc agg aaa cag cag 671 Val Trp Thr Arg Ser Arg Asp Pro Glu Gly Ser Ser Arg Lys Gln Gln 21 0 215 220 ccc atg gag aat gga gga aag tcg ttg ccc ccc aca cgc cga gcg ccc 719 Pro Met Glu Asn Gly Gly Lys Ser Leu Pro Pro Thr Arg Arg Ala Pro 225 230 235 tct tct ggg gac gat cag agc agc agc tca cag ccc ccg cgg gag 767 Ser Ser Gly Asp Asp Gln Ser Ser Ser Ser Thr Gln Pro Pro Arg Glu 240 245 250 255 gtg ggc act tcc aat ggc cga ggt ttt tct cat ccc ctg cat tgt ggt 815 Val Gly Thr Ser Asn Gly Arg Gly Phe Ser His Pro Leu His Cys Gly 260 265 270 ggg aca ccc agc cag gca ccc ttt tta aac cag atg agg cca gca gta 863 Gly Thr Pro Ser Gln Ala Pro Phe Leu Asn Gln Met Arg Pro Ala Val 275 280 285 cca gga aca ttt ggc cct ctg cga gga tca gat cct gcc acc ttg tat 911 Pro Gly Thr Phe Gly Pro Leu Arg Gly Ser Asp Pro Ala Thr Leu Tyr 290 295 300 ggc tcc tct gga gtc ctg gag cca cac ccc ggg gag cct gtg cag 959 Gly Ser Ser Gly Val Leu Glu Pro His Pro Gly Glu Pro Val Gln Gln 305 310 315 cgt cag cct ttc acc atg cag cct cca gtt gga att aac agc ctc cga 1007 Arg Gln Pro Phe Thr Met Gln Pro Pro Val Gly Ile Asn S er Leu Arg 320 325 330 335 gga ccc agg cta ggc aca cca gag gag aag caa atg tgc ggg ggg ctg 1055 Gly Pro Arg Leu Gly Thr Pro Glu Glu Lys Gln Met Cys Gly Gly Leu 340 345 350 aca cac ctt tct aac atg gg cca cac cct gga tcc ttg cag ctt ggg 1103 Thr His Leu Ser Asn Met Gly Pro His Pro Gly Ser Leu Gln Leu Gly 355 360 365 cag ata agt ggc cca agt cag gat gga agc atg tat gct cca gct cag 1151 Gln Ile Ser Gly Pro Ser Gln Asp Gly Ser Met Tyr Ala Pro Ala Gln 370 375 380 ttc cag cca gga ttc att cct ccc cgg cat ggg ggg gct cca gcc cgg 1199 Phe Gln Pro Gly Phe Ile Pro Pro Arg His Gly Gly Ala Pro Ala Arg 385 390 395 cca cca gac ttt cct gaa agc tca gaa att cct ccc agc cat atg tat 1247 Pro Pro Asp Phe Pro Glu Ser Ser Glu Ile Pro Pro Ser His Met Tyr 400 405 410 415 cga tcg tac aag tac ctg aat cga gta cac tct gcc gtc tgg aat ggg 1295 Arg Ser Tyr Lys Tyr Leu Asn Arg Val His Ser Ala Val Trp Asn Gly 420 425 430 aac cat ggt gct acg aac caa gga ccc ttg ggc cca gat gag aag ccc 1343 Asn His Gly Ala Thr Asn Gln Gl y Pro Leu Gly Pro Asp Glu Lys Pro 435 440 445 cac ctg ggg cca gga ccc tct cac cag cct cgc act ctc ggt cac gtg 1391 His Leu Gly Pro Gly Pro Ser His Gln Pro Arg Thr Leu Gly His Val 450 455 460 atg gat tcc cga gtc atg aga cca cct gtc ccc ccc aac cag tgg act 1439 Met Asp Ser Arg Val Met Arg Pro Pro Val Pro Pro Asn Gln Trp Thr 465 470 475 gaa caa tca ggc ttc cta cct cat gga gtt cct tcc tca ggg tac atg 1487 Glu Gln Ser Gly Phe Leu Pro His Gly Val Pro Ser Ser Gly Tyr Met 480 485 490 495 cga ccg ccc tgc aag tct gcc gga cat cgg tta cag cca cct cca gtg 1535 Arg Pro Pro Cys Lys Ser Ala Gly His Arg Leu Gln Pro Pro Pro Val 500 505 510 cca gca ccc agt tct ttg ttt gga gca cct gcc cag gct ctt cgg ggg 1583 Pro Ala Pro Ser Ser Leu Phe Gly Ala Pro Ala Gln Ala Leu Arg Gly 515 520 525 gtg cag gga ggg gac tcc atg atg gac agc cca gag atg att gcg atg 1631 Val Gln Gly Gly Asp Ser Met Met Asp Ser Pro Glu Met Ile Ala Met 530 535 540 cag cag ctc tcc tcc cgc gtc tgc ccc cca ggt gtg cct tac cac ccc G679 Gln Ser Ser Arg Val Cys Pro Pro Gly Val Pro Tyr His Pro 545 550 555 cac cag cct gca cac ccc cgt tta cct ggc cct ttt ccg cag gta gct 1727 His Gln Pro Ala His Pro Arg Leu Pro Gly Pro Phe Pro Gln Val Ala 560 565 570 575 cac cca atg tca gtc act gtg tca gcc ccc aag cct gcc ctg ggc aac 1775 His Pro Met Ser Val Thr Val Ser Ala Pro Lys Pro Ala Leu Gly Asn 580 585 590 cct ggg agg gca ccg gag aac agt gaa gca caa gag cct gag aat gac 1823 Pro Gly Arg Ala Pro Glu Asn Ser Glu Ala Gln Glu Pro Glu Asn Asp 595 600 605 caa gca gag ccg ttg cct ggc ctt gaa gag aaa cca cca ggt gtt ggt 1871 Gln Ala Glu Pro Leu Pro Gly Leu Glu Glu Lys Pro Pro Gly Val Gly 610 615 620 act tca gag ggg gtc tac ctc aca caa cta cct cac ccc aca cct ccc 1919 Thr Ser Glu Gly Val Tyr Leu Thr Gln Leu Pro His Pro Thr Pro Pro 625 630 635 ctg cag act gac tgc acc agg cag agc tca cca caa gaa agg gaa aca 1967 Leu Gln Thr Asp Cys Thr Arg Gln Ser Ser Pro Gln Glu Arg Glu Thr 640 645 650 655 gtg ggc ccg gag ctc aaa agc agc tcc tcc ga tct aac tgt 2015 Val Gly Pro Glu Leu Lys Ser Ser Ser Ser Glu Ser Ala Asp Asn Cys 660 665 670 aaa gca atg aag ggc aag aat ccc tgg ccc tcg gat agc agc tac ccc 2063 Lys Ala Met Lys Gly Lys Asn Pro Trp Pro Ser Asp Ser Ser Tyr Pro 675 680 685 ggc cca gcc gcc caa ggg tgc gtg aga gac ctc tcc acg gtg gca gac 2111 Gly Pro Ala Ala Gln Gly Cys Val Arg Asp Leu Ser Thrl Val Ala Asp 690 695 700 agg ggc gct cta tcc gag aac gga gtc att ggg gaa gca tct cct tgt 2159 Arg Gly Ala Leu Ser Glu Asn Gly Val Ile Gly Glu Ala Ser Pro Cys 705 710 715 gga tcg gag ggg aag ggc ctt ggt agc agt ggt tcc gaa aag ctg ctc 2207 Gly Lys Gly Leu Gly Ser Ser Gly Ser Glu Lys Leu Leu 720 725 730 735 tgc ccc aga ggc aga acg ttg cag gaa acc atg cca tgc acg gga cag 2255 Cys Pro Arg Gly Arg Thr Leu Gln Glu Thr Met Pro Cys Thr Gly Gln 740 745 750 aac gca gcg aca ccg ccc agc aca gac ccc ggt ttg acg gga ggc act 2303 Asn Ala Ala Thr Pro Pro Ser Thr Asp Pro Gly Leu Thr Gly Gly Thr 755 760 765 gtg agc cag ttt ccc ccg ctg tat atg c ct ggc cta gag tac ccg aat 2351 Val Ser Gln Phe Pro Pro Leu Tyr Met Pro Gly Leu Glu Tyr Pro Asn 770 775 780 tca gct gcc cat tac cac atc agt cca ggc ctg cag ggt gtg ggc cct 2399 Ser Ala Ala His Tyr His Ile Ser Pro Gly Leu Gln Gly Val Gly Pro 785 790 795 gtg atg gga ggg aag tcc cca gca tcc cat ccc cag cat ttt ccc cca 2447 Val Met Gly Gly Lys Ser Pro Ala Ser His Pro Gln His Phe Pro 800 805 810 815 815 agg ggc ttt cag tct aac cac cca cat tct gga ggc ttt ccc cgg tat 2495 Arg Gly Phe Gln Ser Asn His Pro His Ser Gly Gly Phe Pro Arg Tyr 820 825 830 cgc ccc cca caa gga atg agg tat tcc tac cac cca ccgca cag cct 2543 Arg Pro Pro Gln Gly Met Arg Tyr Ser Tyr His Pro Pro Gln Pro 835 840 845 tcc tac cac cac tat cag cga act cct tac tat gcc tgt cca cag agc 2591 Ser Tyr His His Tyr Gln Arg Thr Pro Tyr Tyr Ala Cys Pro Gln Ser 850 855 860 ttt tct gac tgg cag aga cct ctc cat ccc cag gga agc cca agc gga 2639 Phe Ser Asp Trp Gln Arg Pro Leu His Pro Gln Gly Ser Pro Ser Gly 865 870 875 ccc cca gcc agt ca g cct ccc cca cca agg tcc ctc ttc tca gat aag 2687 Pro Pro Ala Ser Gln Pro Pro Pro Pro Arg Ser Leu Phe Ser Asp Lys 880 885 890 890 895 aat gcc atg gcc agt ctg caa ggc tgt gag aca ctg aat gct gcc tta 2735 Asn Ala Met Ala Ser Leu Gln Gly Cys Glu Thr Leu Asn Ala Ala Leu 900 905 910 act tct cca acc cgt atg gat gca gtg gct gct aaa gtc cca aat gac 2783 Thr Ser Pro Thr Arg Met Asp Ala Val Ala Ala Lys Val Pro Asn Asp 915 920 925 ggg cag aat cct ggt cca gag gaa gag aag ctg gat gaa tct atg gag 2831 Gly Gln Asn Pro Gly Pro Glu Glu Glu Glu Lys Leu Asp Glu Ser Met Glu 930 935 940 agg cca gag agt tcc aaa gaa gac ctg gac aac cat aac gca 2879 Arg Pro Glu Ser Pro Lys Glu Phe Leu Asp Leu Asp Asn His Asn Ala 945 950 955 gct acc aag cgg cag agc tcg ttg tca gcc agc gag tat ctc tat gga 2927 Ala Thr Lys Arg Ser Ser Leu Ser Ala Ser Glu Tyr Leu Tyr Gly 960 965 970 975 act cct ccg cct ctg agt tca gga atg gga ttt ggt tca tct gca ttt 2975 Thr Pro Pro Pro Leu Ser Ser Gly Met Gly Phe Gly Ser Ser Ala Phe 980 985 990 cca ccc cac agt gtg atg ctg cag acg ggg cct ccc tat acc cct cag 3023 Pro Pro His Ser Val Met Leu Gln Thr Gly Pro Pro Tyr Thr Pro Gln 995 1000 1005 cgg ccg gcc agt cac ttt cag ccc agg gct tac tct tcc cct gtg gct 3071 Arg Pro Ala Ser His Phe Gln Pro Arg Ala Tyr Ser Ser Pro Val Ala 1010 1015 1020 gcc ctc cca cct cac cac cca ggg gcc acc cag ccc aac ggc ctc tct 3119 Ala Leu Pro Pro His His Pro Gly Ala Thr Gln Pro Asn Gly Leu Ser 1025 1030 1035 cag gag ggt ccc atc tat cgc tgc cag gaa gaa ggc ctg ggt cac ttt 3167 Gln Glu Gly Pro Ile Tyr Arg Cys Gln Glu Glu Gly Leu Gly His Phe 1040 1045 1050 1055 cag atg gaa caa att ggc act aga agt gga ata aga gga 3215 Gln Ala Val Met Met Glu Gln Ile Gly Thr Arg Ser Gly Ile Arg Gly 1060 1065 1070 cct ttc cag gaa atg tac aga cca tca gga atg cag atg cac ccg gt Phe Gln Glu Met Tyr Arg Pro Ser Gly Met Gln Met His Pro Val 1075 1080 1085 cag tcg cag gcc tcg ttc cca aag acc ccc aca gca gca aca tca cag 3311 Gln Ser Gln Ala Ser Phe Pro Lys T hr Pro Thr Ala Ala Thr Ser Gln 1090 1095 1100 gag gag gtg ccg cct cat aag cct cca aca ctt ccc ctg gat cag agc 3359 Glu Glu Val Pro Pro His Lys Pro Pro Thr Leu Pro Leu Asp Gln Ser 1105 1110 1115 tagtccaagg aggaaatgag cccag tggaaagctg cacacgaaga ctggaatgtg 3419 gagaactggg gagtgccctg tcagctctat tcccatcacc tgctccaccc cttcacggcg 3479 acccactcgt gccatacttg agctggagcc agtcacgggc cctaaaagga cactccttag 3539 atgactgaca cacagattgc aaaggtcctc ggccagggat ctcttgcaca gctgatgtag 3599 acagtcaggc aaaactaatg aacgtggagt taatgatgac ttttccaaat cctgagacac 3659 ttttcaggga aaatcacttt aaacttgggg gagggggtat actcaagaat ggagtggtgc 3719 ttttaaactt tgatgagcag ctaaactcag gtatatattt ggggaaggga ctactcttag 3779 tattaatggt tttggagctg ggtccagttt acagaatttt catgttgcct tttaaaat 3837 <210> 219 <211> 4281 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3274) <400> 219 g atc ttc gtg gcc gag ctg aag gac cca tcg cag gtc ccc atc tac agc 49 Ile Phe Val Ala Glu Leu Lys Asp Pro Ser Gln Val Pro Ile Tyr Ser 1 5 10 15 ctc cgg aag ggc cgg ctg cag cgt gtg ggg ctt gag agg ctc acc gcc 97 Leu Arg Lys Gly Arg Leu Gln Arg Val Gly Leu Glu Arg Leu Thr Ala 20 25 30 gag gcc cgg cac agc cgg ctc ttc tgg gtc caa att gtc ctg tgg cgg 145 Glu Ala Arg Arg Leu Phe Trp Val Gln Ile Val Leu Trp Arg 35 40 45 caa ggc ttc tac tac ccg ctg ggc atc gtc cgg gag gtg ctg cct gag 193 Gln Gly Phe Tyr Tyr Pro Leu Gly Ile Val Arg Glu Val Leu Pro Glu 50 55 60 gcc agc acc tgg gag cag ggc ctc cgc atc ctc ggc ctg gag tac agc 241 Ala Ser Thr Trp Glu Gln Gly Leu Arg Ile Leu Gly Leu Glu Tyr Ser 65 70 75 80 ttg agg gtg ccc ccg tcg gac cag gacc acc ggt ctg cag 289 Leu Arg Val Pro Pro Ser Asp Gln Ala Thr Ile Thr Lys Val Leu Gln 85 90 95 aaa tac cac acg gag ctt ggc cgg gtt gcc ggc cgc cga gag gac tgc 337 Lys Tyr His Thr Glu Leu Gly Arg Val Ala Gly Arg Arg Glu Asp Cys 100 105 110 cgc gcc ttc ttg acc ttc act gtg gac ccc cag ggc gcc tgc aac ctc 385 Arg Ala Phe Leu Thr Phe Thr Val Asp Pro Gln Gly Ala Cys Asn Leu 115 120 125 gat gat gcc ctc agt gtc cga gac ctg gc ccc gag gtg gct 433 Asp Asp Ala Leu Ser Val Arg Asp Leu Gly Pro Arg Cys Glu Val Ala 130 135 140 gtg cac atc act gat gtg gcc agc ttc gtg ccc agg gac ggg gtg ctg 481 Val His Ile Thr Asp Val Ala Ser Phe Val Pro Arg Asp Gly Val Leu 145 150 155 160 gac gtg gag gcg cga agg cag ggc gct gcg ttc tat gcc ccc ggc agg 529 Asp Val Glu Ala Arg Arg Gln Gly Ala Ala Phe Tyr Ala Pro Gly Arg 165 170 175 gag ccagt atg ctg ccg gcc agc ctc tgc cag gac gtc ctc agc 577 Glu Pro Val Pro Met Leu Pro Ala Ser Leu Cys Gln Asp Val Leu Ser 180 185 190 ctc ctg cct ggc cgg gac cgc ctg gcc atc tcc ctg acctc ctg ccc Leu Pro Gly Arg Asp Arg Leu Ala Ile Ser Leu Phe Leu Thr Met 195 200 205 gag aag gcc agt ggc cag ctg aag agc ctg cgc ttt gca ccc tcc gtg 673 Glu Lys Ala Ser Gly Gln Leu Lys Ser Leu Arg Phe Ala SerVal 210 215 220 gtc cag tct gac cgc cag ctg tcc tac gag gag gcg gag gag gtg atc 721 Val Gln Ser Asp Arg Gln Leu Ser Tyr Glu Glu Ala Glu Glu Val Ile 225 230 235 240 agg cag cac ccg ggt gcc ggc cgg ctg ccg gcc cgc ctg gac tcc 769 Arg Gln His Pro Gly Ala Gly Arg Glu Leu Pro Ala Arg Leu Asp Ser 245 250 255 gtg gac gcc tgc gtc gtg gcc gcg tgc tac ttc tct cgg ctg ctg Agc Cyc Val Val Ala Ala Cys Tyr Phe Ser Arg Leu Leu Arg 260 265 270 cgg cac cgc ctg cgg tcc gac tgc ttc tat gag cag ccg gac gag gac 865 Arg His Arg Leu Arg Ser Asp Cys Phe Tyr Glu Gln Pro Asp Glu Asp gg 280 285 280 acc ctg ggc ttc cgc gcg gcc cac atc atg gtg aag gag tac atg 913 Gly Thr Leu Gly Phe Arg Ala Ala His Ile Met Val Lys Glu Tyr Met 290 295 300 att cag ttt aat agg ctc gtg gct gag gtc ggg tgc 961 Ile Gln Phe Asn Arg Leu Val Ala Glu Phe Leu Val Gly Ser Glu Cys 305 310 315 320 acg cgg acg gtc acg cct ctg cgg tgg cag cca gca ccc cgc agc cag 1009 Thr Arg Thr Val Thr Pro Leu Arg Trp Gln Pro Ala Pro Arg Ser Gln 325 330 335 cag ctc aag gcc ctg tgt gag aag cat ggg gac cgg gtg ccc ctg tca 1057 Gln Leu Lys Ala Leu Cys Glu Lys His Gly Asp Arg Val Pro Leu Ser 340 345 350 ctg cac ctc ggc cac ctg cac ggc ggc ggg ggc agt ccc ccc gac 1105 Leu His Leu Gly His His Leu His Gly Gly Gly Gly Ser Pro Pro Asp 355 360 365 acg cgg ctg cac ctc ctg gcc tcc ctc tgg aag cag gtc cag ttt gct 1153 Thr Arg His Leu Leu Ala Ser Leu Trp Lys Gln Val Gln Phe Ala 370 375 380 gcc cgc acc cag gac tac gaa cag atg gtg gac ttg gtc acc acg gac 1201 Ala Arg Thr Gln Asp Tyr Glu Gln Met Val Asp Leu Val Thr Thr Asp 385 390 395 400 gac atg cac cca ttc ctg gct cct gca ggc cgc gac ctc cgc aag gcc 1249 Asp Met His Pro Phe Leu Ala Pro Ala Gly Arg Asp Leu Arg Lys Ala 405 410 415 ctg gag cgc tcg gcg ggc ttc ggc cac cag cag cag 1297 Leu Glu Arg Ser Ala Phe Gly Arg Cys Ala Arg Gly His Gln Gln Gln 420 425 430 ggc ggc cac tac tcg ctg cag gtg gac tgg tac acg tgg gcc acc tcg 1345 Gly Gly His Tyr Seru Gln Val Asp Trp Tyr Thr Trp Ala Thr Ser 435 440 445 ccc atc cgc agg tac ctg gac gtg gtg ttg cag cgg cag atc ctg ctg 1393 Pro Ile Arg Arg Tyr Leu Asp Val Val Leu Gln Arg Gln Ile Leu Lec 450 455 g ctg ggc cat ggg ggc tct gcc tac tct gcc agg gac atc gat ggg 1441 Ala Leu Gly His Gly Gly Ser Ala Tyr Ser Ala Arg Asp Ile Asp Gly 465 470 470 475 480 ctc tgc cag gcc ttc agc ctc cag cac gctt tat cag 1489 Leu Cys Gln Ala Phe Ser Leu Gln His Ala Leu Ala Gln Ser Tyr Gln 485 490 495 cgg cgg gcg cgc agc ctg cac ctg gcc gtg cag ctc aag gcc cag cct 1537 Arg Arg Ala Arg Ser Leu His Leu Ala Leu Lys Ala Gln Pro 500 505 510 ctg gac aag ctg ggc ttc gtg gtg gac gtg gag gcg ggc tcc cgc tgc 1585 Leu Asp Lys Leu Gly Phe Val Val Asp Val Glu Ala Gly Ser Arg Cys 515 ct ttcc cgg agc aac cgg gag acg ctg cct gac ccc tgc 1633 Phe Arg Leu Leu Phe Pro Ser Asn Arg Glu Thr Leu Pro Asp Pro Cys 530 535 540 ccc gtc ccc tac ggc tcc ctg cag ctg gcc gag cac ccc cac gcc ctg 1681 Val Pro Tyr Gly Ser Leu Gln Leu Ala Glu His Pro His Ala Leu 545 550 555 560 gca ggc cgg ccg ggc ctg cgg ctc ctg tgg cgg cgc cgt gtc tac tca 1729 Ala Gly Arg Pro Gly Leu Arg Leu Leu Trp Arg Arg Tyr Ser 565 570 575 gcg cag gga tcc agc ccg ccc ctg cca ctg cct ggc act gtg ccg gac 1777 Ala Gln Gly Ser Ser Pro Pro Leu Pro Leu Pro Gly Thr Val Pro Asp 580 585 590 cca cac acc ctg gcc gtg gag acg ctg tgg aag cag ctg ctg gag 1825 Pro His Thr Leu Ala Val Glu Thr Ala Leu Trp Lys Gln Leu Leu Glu 595 600 605 ctg gtg gag ctg cag cgc tgg ccg gag gcg gct gct ctc atc cag gag 1873 Leu Val Glu Trp Pro Glu Ala Ala Ala Leu Ile Gln Glu 610 615 620 aag ggc gag gcg tcc cag cgg cgg gag ctg gtg cag gtg cag cgg agc 1921 Lys Gly Glu Ala Ser Gln Arg Arg Glu Leu Val Gln Val Gln Arg Ser 630 630 cac tgt ggc cat ttc ctg gag gtg gcc cgg gag ctg ggc agt ggg gac 1969 His Cys Gly His Phe Leu Glu Val Ala Arg Glu Leu Gly Ser Gly Asp 645 650 655 acc ctg cag gtg cag ctc ggc acc agc gg cag c ttc ctg gta 2017 Thr Leu Gln Val Gln Leu Gly Thr Ser Leu Gln His Gly Phe Leu Val 660 665 670 ccg agc cct cag ctc tgg acg gtg gca ccg ggc ttc agc ctc tgc ctg 2065 Pro Ser Pro Gln Leu Trp Pro Gly Phe Ser Leu Cys Leu 675 680 685 gag cac gtg gag cgg ccc gga gac tgc ttc tca ggc cgt gtg tac cgg 2113 Glu His Val Glu Arg Pro Gly Asp Cys Phe Ser Gly Arg Val Tyr Arg 690 695 700 gcc ccg agg cgg tac cgc gac gtg gat gag tac gcc tgc gtg tgg 2161 Ala Pro Arg Asp Arg Tyr Arg Asp Val Asp Glu Tyr Ala Cys Val Trp 705 710 710 715 720 gaa cca ttc tgc gcc ctg gag tcg gcc acc ggc gag gtt Glu Pro Phe Cys Ala Leu Glu Ser Ala Thr Gly Ala Val Ala Glu Asn 725 730 735 gac tcc gtc aca ctt cag cac ctg agt gtc tcc tgg gag gcg tca cgg 2257 Asp Ser Val Thr Leu Gln His Leu Ser Val Ser Trp Glu Ala Ser Arg 740 745 750 acg ccg cag ggg cag ctg cag ggc gcc ttc cgc ctg gag gcc gcc ttc 2305 Thr Pro Gln Gly Gln Leu Gln Gly Ala Phe Arg Leu Glu Ala Ala Phe 755 760 765 ctc gag gag aac g aac ttc agc tgc tgc tac ctc tgc 2353 Leu Glu Glu Glu Asn Cys Ala Asp Ile Asn Phe Ser Cys Cys Tyr Leu Cys 770 775 780 atc cgg ctc gag ggg ctg ccg gct ccc acg gcc agc cca cgc Ggg Arg Leu Pro Ala Pro Thr Ala Ser Pro Arg Pro Gly 785 790 795 800 ccc agc agc ctc ggc cct ggc ctg aat gtt gac ccc ggc acg tat acc 2449 Pro Ser Ser Leu Gly Pro Gly Leu Asn Val Asp Pro Gly Thr Tyr Thr 805 810 815 tgg gtg gcc cac ggg cag acg cag gac tgg gac cag gag cgc cgg gca 2497 Trp Val Ala His Gly Gln Thr Gln Asp Trp Asp Gln Glu Arg Arg Ala 820 825 830 gac cgg cag gag gct ccc aga cgg gtg cac ctc cac cac atg 2545 Asp Arg Gln Glu Ala Pro Arg Arg Val His Leu Phe Val His His Met 835 840 845 ggc atg gag aag gtt ccg gaa gag gtg ctg agg ccg ggc acc ctg ttc 2593 Gly Met Glu Lys Val Pro Glu Glu Val Arg Pro Gly Thr Leu Phe 850 855 860 acc gtt gag ctg ctg ccc aag cag ctt cct gat ctc cgc aag gag gaa 2641 Thr Val Glu Leu Leu Pro Lys Gln Leu Pro Asp Leu Arg Lys Glu Glu 865 870 875 880 gcc gtg cgt gga cta gag gag gcg tcc ccg ctg gtc acc agc atc gca 2689 Ala Val Arg Gly Leu Glu Glu Ala Ser Pro Leu Val Thr Ser Ile Ala 885 890 895 ctg ggc cgg cct gtc ccg cag ccc ctc tgc aga ggt 2737 Leu Gly Arg Pro Val Pro Gln Pro Leu Cys Arg Gly Arg Ser Ala Pro 900 905 910 ccc ctc cag ctt ccc ctc tgg ccc cca gcc cca ccc tgc atg agt gct 2785 Pro Leu Gln Leu Pro Leu Trp Pro Pro Ala Pro Pro Cys Met Ser Ala 915 920 925 cag gga ggc tgc ccc ctc tca gtg atc ccc agc agg ttc ctg gag cgg 2833 Gln Gly Gly Cys Pro Leu Ser Val Ile Pro Ser Arg Phe Leu Glu Arg 930 935 940 940 cag acc tac aac atc ccc cgc cac aag ctg aac ccc agc cag 2881 Gln Thr Tyr Asn Ile Pro Gly Gly Arg His Lys Leu Asn Pro Ser Gln 945 950 955 960 aac gtg gcg gtc agg gag gct ctg gag aag cct ttc acg gtc att Aca 2929 Asn Arg Glu Ala Leu Glu Lys Pro Phe Thr Val Ile Gln 965 970 975 ggc cca cca ggt agg gcc cat gcc ggg gga gcc gca ggc tgc ctt ggg 2977 Gly Pro Pro Gly Arg Ala His Ala Gly Gly Ala Ala Gly Cys Leu Gly 980 985 990 cca cag gga ccc aca ggg tgg gct aca atc tcc tat tct ctg gct gca 3025 Pro Gln Gly Pro Thr Gly Trp Ala Thr Ile Ser Tyr Ser Leu Ala Ala 995 1000 1005 ggt aca ggg aag acg atc gtg ggc ctc cac atc gta ttc tgg ttt cat 3073 Gly Thr Gly Lys Thr Ile Val Gly Leu His Ile Val Phe Trp Phe His 1010 1015 1020 aaa tca aac cag gag cag gtg cag ccc gga ggc ccc ccc cgt ggg gag 3121 Lys Ser Asn Gln Glu Gln Val Gln Pro Gly Gly Pro Pro Arg Gly Glu 1025 1030 1035 1040 aag cgg ctg ggg ggt ccc tgc atc ttg tac tgc ggc ccc tcc aac aag 3169 Lys Arg Leu Gly Gly Pro Cys Ile Leu Tyr Cys Gly Pro Ser Asn Lys 1045 1050gtg gat gtc ctg gca ggt gcg ccg ggg tcg gcg gtg ggg gcc ttt 3217 Ser Val Asp Val Leu Ala Gly Ala Pro Gly Ser Ala Val Gly Ala Phe 1060 1065 1070 ggg gag ctg gca cgc ggg gca gga ctc acg tcc ccc ag 3265 Gly Glu Leu Ala Arg Gly Ala Gly Leu Thr Ser Pro Asn Tyr Pro Gln 1075 1080 1085 gac tgc tcc tgagaaggat ggagctgaag cccctccgtg tgtacagtga 3314 Asp Cys Ser 1090 gcaggctgag gccagcg agt tcccagtgcc gcgtgtgggc agcaggaagc tgctcaggaa 3374 gagcccccgg gaggggaggc cgaaccagag cctcaggagc atcaccctgc accaccggat 3434 ccggcaggcc cccaaccctt actcgtcgga aatcaaggcc tttgacaccc ggctgcagag 3494 aggggagctc ttctccaggg aggacctggt ctggtacaag aaggtcttgt gggaggctcg 3554 gaagttcgag ctggaccggc atgaggtcat cctctgcacc tgctcctgtg cagcctctgc 3614 cagcctcaaa atcctggacg tgaggcagat ccttgttgac gaggcaggca tggccacgga 3674 acctgaaacc ctcatccccc tggtgcagtt cccacaggcc gagaaggtgg ttcttctcgg 3734 agaccacaag cagctgcggc ctgtggtcaa gaatgagcgg ctgcaaaacc tgggtctgga 3794 ccggtctctg ttcgagcggt accacgagga cgcacatatg ctggacactc agtaccgcat 3854 gcatgagggc atctgtgcct tcccctctgt ggcgttctac aagagcaagc tgaagacgtg 3914 gcagggcctg aggaggccgc ccagtgtcct gggccacgct ggcaaggaga gctgccctgt 3974 catctttggc cacgtgcagg gccacgagcg gagcctgctg gtgtccacgg acgaagggaa 4034 tgagaactcc aaggccaacc tggaggaggt ggctgaggtg gtccgtatca ccaagcagct 4094 gaccctgggg aggaccgtag agccccagga catcgccgtc ctcacgccct acaacgcgca 4154 ggcctctgag atcagcaagg c ccttcggcg agagggcatc gccggggtgg ccgtgtcctc 4214 catcaccaag agccagggtg aggctggggg ctcgtgggtg gggccgggag ggtgggcgca 4274 gcggccg 4281 <210> 220 <211> 4358 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (653) .. (4024) <400> 220 ctgtgaaccc ctctaaatgc ggttgcccct ttgccttgaa gatggcagca tgtcagcttc 60 ttctggagat taccaccttc ctgcgagaga ccttttcttg cctgcccaga cctcgcactg 120 agcctctggt ggacttggag agctgcagac ttcgtttgga tcccgagttg gaccggcaca 180 gatatgagag gaagatcagc tttgctgggg tcctggacga aaatgaagac tcaaaagatt 240 ctctccacag cagcagccac actctcaaat cagatgcagg agtcgaggag aagaaagttc 300 ccagcaggaa gatcaggata ggaggttctc gcctgctcca gattaaagga acccgcagtt 360 tccaggtgaa gaaggggggt tccttgtcca gcattcgccg ggtcggcagc ttaaagagca 420 gcaagttatc acggcaggac tcagagtctg aggctgagga gctgcagctg tcccagagca 480 gggacactgt cactgaccta gaagggagtc cttggagtgc aagcgagccc agcattgagc 540 cagagggaat gagtaatgcc ggcgcggagg agaattacca cagaaacatg tcgtggcttc 600 atgtgatgat cttgctgtgc aatcagcaga gtttcatctg cactcacgtt ga cta ctg 658 Leu Leu 1 cca tcc cca ctg cta cct gca cca cag ccg ctc ctg tgc ccg act ggt 706 Pro Ser Pro Leu Leu Pro Ala Pro Gln Pro Leu Leu Cys Pro Thr Gly 5 10 15 cag agc cat caa gct act cta tgg aga cag tgt gga ctc cct gag gga 754 Gln Ser His Gln Ala Thr Leu Trp Arg Gln Cys Gly Leu Pro Glu Gly 20 25 30 agc agc aac atc agc agt gtg gct ctc cgg ggc aag aaa cag aaa gaa 802 Ser Ser Asn Ile Ser Ser Val Ala Leu Arg Gly Lys Lys Gln Lys Glu 35 40 45 50 tgc tca gat aag tca tgc ctg agg aca cct tct cta aag aag aga gtt 850 Cys Ser Asp Lys Ser Cys Leu Arg Thr Pro Ser Leu Lys Lys Arg Val 55 60 65 tca gat gcc aat ctg gaa gga aaa aaa gat tcc gga atg ctg aag tac 898 Ser Asp Ala Asn Leu Glu Gly Lys Lys Asp Ser Gly Met Leu Lys Tyr 70 75 80 atc aga ctt cag gtg atg agc ttg tcg cct gct ccc tta tct ctg tta 946 Ile Arg Leu Gln Ser Leu Ser Pro Ala Pro Leu Ser Leu Leu 85 90 95 atc aag gca gca cca att ctg aca gag gag atg tac gga gac atc cag 994 Ile Lys Ala Ala Pro Ile Leu Thr Glu Glu Met Tyr Gly Asp Ile Gln 100 105 110 cca gct gcc tgg gag ctc ctg ctc agc atg gat gag cac atg gca ggg 1042 Pro Ala Ala Trp Glu Leu Leu Leu Ser Met Asp Glu His Met Ala Gly 115 120 125 130 gca gca gct gcc atg ttc ctg ctg tgt gca gtg ag gag gcc 1090 A la Ala Ala Ala Met Phe Leu Leu Cys Ala Val Lys Val Pro Glu Ala 135 140 145 gtg tcc gac atg ctg atg tca gag ttc cac cac ccg gag act gtg cag 1138 Val Ser Asp Met Leu Met Ser Glu Phe His Pro Glu Thr Val Gln 150 155 160 agg ctg aac gct gtc ctc aag ttc cac acg ctc tgg agg ttt cgc tat 1186 Arg Leu Asn Ala Val Leu Lys Phe His Thr Leu Trp Arg Phe Arg Tyr 165 170 175 cag gtc tgg ccc cgg atg gga gca cag cag att ttt aag att 1234 Gln Val Trp Pro Arg Met Glu Glu Gly Ala Gln Gln Ile Phe Lys Ile 180 185 190 ccg cct ccc agt atc aat ttc acc ctt ccc tcg ccg gtg ctt gga atg 1282 Pro Pro Pro Ser Ile Asn Phe Thr Leu Pro Ser Pro Val Leu Gly Met 195 200 205 210 cca tcc gtc cca atg ttt gac cca ccg tgg gtt cct cag tgc agc ggg 1330 Pro Ser Val Pro Met Phe Asp Pro Pro Trp Val Pro Gln Cys Ser Gly 215 220 225 agt gtc cag gac ccc att aat gaa gac cag tct aaa tcc ttt tca gcc 1378 Ser Val Gln Asp Pro Ile Asn Glu Asp Gln Ser Lys Ser Phe Ser Ala 230 235 240 cgg gct gtg tcc cgc tcc cat caa agg gca gaa cac at c tta aag aac 1426 Arg Ala Val Ser Arg Ser His Gln Arg Ala Glu His Ile Leu Lys Asn 245 250 255 ttg cag cag gag gaa gaa aag aaa cga ctt ggt aga gaa gcc agc ctc 1474 Leu Gln Gln Glu Glu Glu Lys Lys Arg Leu Gly Arg Glu Ala Ser Leu 260 265 270 atc act gcc atc ccc atc acc cag gag gct tgc tat gag ccc aca tgc 1522 Ile Thr Ala Ile Pro Ile Thr Gln Glu Ala Cys Tyr Glu Pro Thr Cys 275 280 285 290 290 acg ccc aac tca gaa ccg gaa gaa gaa gaa gaa gtc acc aat ctg gca 1570 Thr Pro Asn Ser Glu Pro Glu Glu Glu Glu Glu Val Thr Asn Leu Ala 295 300 305 tcc cgt cga ctg tct gtg agt cca tcc tgc acc tcc agc act Ser Arg Arg Leu Ser Val Ser Pro Ser Cys Thr Ser Ser Thr Ser His 310 315 320 agg aat tat tcc ttc cgc cgc ggg tca gtc tgg tca gtg cgt tca gcc 1666 Arg Asn Tyr Ser Phe Arg Arg Gly Ser Val Trp Ser Val Arg Ser Ala 325 330 335 gtc agt gct gaa gat gag gaa cat acc act gaa cac acg ccg aac cac 1714 Val Ser Ala Glu Asp Glu Glu His Thr Thr Glu His Thr Pro Asn His 340 345 350 cat gtg cct cag ccc cca caa gca gtg ttc cca gca tgc atc tgt gca 1762 His Val Pro Gln Pro Pro Gln Ala Val Phe Pro Ala Cys Ile Cys Ala 355 360 365 370 gca gta ctt ccc att gtt cat ctg atg gag gat ggt gag gtg cgg gaa 1810 Ala Val Leu Pro Ile Val His Leu Met Glu Asp Gly Glu Val Arg Glu 375 380 385 gat gga gta gca gtg agt gct gtg gct caa caa gtc tta tgg aac tgt 1858 Asp Gly Val Ala Val Ser Ala Val Ala Gln Gln Val Leu Trp Asn Cys 390 395 400 cta att gaa gat cca tca acg gtt ctt cga cat ttt ctg gaa aaa ctg 1906 Leu Ile Glu Asp Pro Ser Thr Val Leu Arg His Phe Leu Glu Lys Leu 405 410 415 acc atc agc aat aga caa gat gag tta atg tac atg ctg cgc aaa ctt 1954 Thr Ile Ser Asn Arg Gln Asp Glu Leu Met Tyr Met Leu Arg Lys Leu 420 425 430 ctc ttg aat att gga gac ttt cct gct cag aca tct cac atc cta ttc 2002 Leu Leu Asn Ile Gly Asp Phe Pro Ala Gln Thr Ser His Ile Leu Phe 435 440 445 450 aac tat ttg gta gga tta atc atg tac ttt gtg cgg acc ccc tgc gag 2050 Asn Tyr Leu Val Gly Leu Ile Met Tyr Phe Val Arg Thr Pro Cys Glu 455 460 465 tgg ggg atg gat gcc att tca gcc acc ctg aca ttc ctg tgg gag gtg 2098 Trp Gly Met Asp Ala Ile Ser Ala Thr Leu Thr Phe Leu Trp Glu Val 470 475 480 gtg ggt tac gtg gag ggc ctc ttc ttc aag gat gatc ag gatc ag gatg atg ag gatc 2146 Val Gly Tyr Val Glu Gly Leu Phe Phe Lys Asp Leu Lys Gln Thr Met 485 490 495 aag aag gag cag tgt gag gtg aag ctc ctg gtg acc gct tca atg cca 2194 Lys Lys Glu Gln Cys Glu Val Lys Leu Leu Val Ala Ser Met Pro 500 505 510 ggt act aaa acc ttg gta gtt cat gga cag aat gag tgc gat atc cca 2242 Gly Thr Lys Thr Leu Val Val His Gly Gln Asn Glu Cys Asp Ile Pro 515 520 525 530 acc cag tta cca gtc cat gaa gac act caa ttt gaa gcc ctg ttg aag 2290 Thr Gln Leu Pro Val His Glu Asp Thr Gln Phe Glu Ala Leu Leu Lys 535 540 545 gag tgt ctg gag ttt ttt aat atc cca gaa tcc cag tca aca cat tat 2338 Glu Cys Leu Glu Phe Phe Asn Ile Pro Glu Ser Gln Ser Thr His Tyr 550 555 560 ttt ctt atg gat aaa cga tgg aac ctt atc cac tac aat aag acc tat 2386 Phe Leu Met Asp Lys Arg Trp Asn Leu Ile His Tyr Asn Lys Thr Tyr 5 65 570 575 gtt cga gat att tat cct ttc cgg agg tca gta tct ccc cag ctg aat 2434 Val Arg Asp Ile Tyr Pro Phe Arg Arg Ser Val Ser Pro Gln Leu Asn 580 585 590 ctt gta cat atg cat cca gag aag gga cag gag ctc att cag aaa cag 2482 Leu Val His Met His Pro Glu Lys Gly Gln Glu Leu Ile Gln Lys Gln 595 600 605 610 gtg ttc acc cga aag ctg gaa gaa gta ggg cgg gtg ttg ttt ctc atc 2530 Val Phe Thr Arlu Lys Glu Val Gly Arg Val Leu Phe Leu Ile 615 620 625 tcc cta acc cag aag atc ccc aca gcc cac aaa cag tcc cac gtc tcc 2578 Ser Leu Thr Gln Lys Ile Pro Thr Ala His Lys Gln Ser His Val Ser 630 635 640 atg ctt cag gaa gac ctc ctc cgc ctg ccc tca ttc cct cgt agt gct 2626 Met Leu Gln Glu Asp Leu Leu Arg Leu Pro Ser Phe Pro Arg Ser Ala 645 650 655 att gat gct gag ttt tca ctc ttc agt gat gct gag gag cga gag gag cga gag 2674 Ile Asp Ala Glu Phe Ser Leu Phe Ser Asp Pro Gln Ala Gly Lys Glu 660 665 670 ctg ttt ggc ctc gac act ctt cag aaa agc ttg tgg atc cag ctg ctg 2722 Leu Phe Gly Leu Asp Thr Leu Gln Lys Seru rp Ile Gln Leu Leu 675 680 685 690 gag gaa atg ttc ctg ggc atg ccg agc gag ttt cca tgg gga gac gaa 2770 Glu Glu Met Phe Leu Gly Met Pro Ser Glu Phe Pro Trp Gly Asp Glu 695 700 tt atc atg aac gtt ttt aac ggg gct ctg atc ctc cac ccg 2818 Ile Met Leu Phe Leu Asn Val Phe Asn Gly Ala Leu Ile Leu His Pro 710 715 720 gaa gac agt gcc ctg ctc agg cag tat gct gcc acc gtc atc aac acc 2866 Ser Ala Leu Leu Arg Gln Tyr Ala Ala Thr Val Ile Asn Thr 725 730 735 gcg gtg cac ttc aac cac ctc ttc tct ctc agc ggc tac cag tgg att 2914 Ala Val His Phe Asn His Leu Phe Ser Leu Ser Gly Tyr Gln Trp 740 745 750 ctc ccc acc atg ctg cag gtg tac tcc gac tat gaa agc aat ccc cag 2962 Leu Pro Thr Met Leu Gln Val Tyr Ser Asp Tyr Glu Ser Asn Pro Gln 755 760 760 765 770 ctg cgt caa gcc atc gaa ttt gcc tgt cag ttc tat att cta cac 3010 Leu Arg Gln Ala Ile Glu Phe Ala Cys His Gln Phe Tyr Ile Leu His 775 780 785 cgg aag ccc ttt gtg ctc cag ctg ttt gct agt gtg gcc cct ctc ctg 3058 Arg Lys Pro u Gln Leu Phe Ala Ser Val Ala Pro Leu Leu 790 795 800 gaa ttt cct gat gct gcc aat aat ggg ccc agc aaa ggt gtg tca gct 3106 Glu Phe Pro Asp Ala Ala Asn Asn Gly Pro Ser Lys Gly Val Ser Ala 805 810 810 815 cag tgc ctg ttt gac ttg ctg cag tcc cta gag gga gag acc acc gac 3154 Gln Cys Leu Phe Asp Leu Leu Gln Ser Leu Glu Gly Glu Thr Thr Asp 820 825 830 ata tta gac atc tta gag ctg gtc cag agct gag cag ag aag tca 3202 Ile Leu Asp Ile Leu Glu Leu Val Lys Ala Glu Lys Pro Leu Lys Ser 835 840 845 850 tta gat ttc tgc tat gga aac gaa gat ctg aca ttt tct atc agt gaa 3250 Leu Asp Phe Cys Tyr Gly Asn Glu Thr Phe Ser Ile Ser Glu 855 860 865 gcc att aag ctc tgt gtc act gtg gtg gcg tat gct ccc gaa tca ttc 3298 Ala Ile Lys Leu Cys Val Thr Val Val Ala Tyr Ala Pro Glu Ser Phe 870 875 880 aga aga agt ctt cag atg ctg atg gtc tta gaa gcc tta gtt cca tgt tac 3346 Arg Ser Leu Gln Met Leu Met Val Leu Glu Ala Leu Val Pro Cys Tyr 885 890 895 cta caa aag cta aag agg cag aca tca cag gtg gag aca gta cct gct 3394 Le Gln Lys Leu Lys Arg Gln Thr Ser Gln Val Glu Thr Val Pro Ala 900 905 910 gcc cga gag gag att gcg gcc act gct gct ctt gcg acg tcc cta cag 3442 Ala Arg Glu Glu Ile Ala Ala Thr Ala Ala Leu Ala Thr Ser Leu Gln 915 920 925 930 gcc ctt ttg tac agt gta gag gtc ctc acc agg ccc atg aca gcc cca 3490 Ala Leu Leu Tyr Ser Val Glu Val Leu Thr Arg Pro Met Thr Ala Pro 935 940 945 cag atg agc agg tgt gac caa ggt cat aag gga acc acc aca gcc aat 3538 Gln Met Ser Arg Cys Asp Gln Gly His Lys Gly Thr Thr Thr Ala Asn 950 955 960 cac acc atg tcg tct ggg gtg aac acc agg tac cag gaa caa gga gcc 3586 His Thr Met Ser Ser Gly Val Asn Thr Arg Tyr Gln Glu Gln Gly Ala 965 970 975 aaa ctg cac ttt atc agg gaa aac ctt cat tta ctg gag gaa ggg caa 3634 Lys Leu His Phe Ile Arg Glu Asn Leu His Leu Leu Glu Glu Gly Gln 980c 990980 att ccc aga gag gaa ctg gat gaa cga att gct cgg gaa gag ttc 3682 Gly Ile Pro Arg Glu Glu Leu Asp Glu Arg Ile Ala Arg Glu Glu Phe 995 1000 1005 1010 aga aga ccc cgg gag tcc tta ctg aat tg ct gag ttc tat aag 3730 Arg Arg Pro Arg Glu Ser Leu Leu Asn Ile Cys Thr Glu Phe Tyr Lys 1015 1020 1025 cac tgt ggg cca cgg ctg aag atc ttg caa aat ctg gct ggg gag cct 3778 His Cys Gly Pro Arg Leu Lys Leu Gln Asn Leu Ala Gly Glu Pro 1030 1035 1040 cgg gtc att gcc ttg gaa ctg ctg gat gtg aag tct cac atg agg ttg 3826 Arg Val Ile Ala Leu Glu Leu Leu Asp Val Lys Ser His Met Arg Leu 1045 1050 ata g gca cac tcc ctt ctg aag ctg gca cca tat gac act cag 3874 Ala Glu Ile Ala His Ser Leu Leu Lys Leu Ala Pro Tyr Asp Thr Gln 1060 1065 1070 aca atg gag agt cgt ggg ctt cgg cgc tac atc atg gag atg cta ccc922 Thr Met Glu Ser Arg Gly Leu Arg Arg Tyr Ile Met Glu Met Leu Pro 1075 1080 1085 1090 att act gac tgg aca gct gag gca gtg agg ccg gcc ctc atc ctc att 3970 Ile Thr Asp Trp Thr Ala Glu Ala Val Arg Pro Ala Leu Ile Leu Ile 1095 1100 1105 tta aaa aga ttg gat aga atg ttc aac aaa att cat aag atg cct act 4018 Leu Lys Arg Leu Asp Arg Met Phe Asn Lys Ile His Lys Met Pro Thr 1110 1115 1120 ttg agg tgagaatgcc tccgagttag ctgttgctat cacaaatgtc aaagttaaga 4074 Leu Arg tttgtcattt tttaagatgg tggatcattc tggagttgaa tggatgactt gaaagttttc 4134 tttggtatat gtgcatagtt aatagggtct atgaatgcct aagtagcaaa gcctacattt 4194 tgagaaaaat aacattttct ttaaaagtat atgtgctcat cttgaaaaaa atctatccat 4254 ttcttagcta tcatgctcct catctgacac atataaaaat ttcaattagt accctttaat 4314 cccttttaaa ataagggagg gttggcctta taaatgaaac aact 4358 <210> 221 <211> 3961 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (3501) <400> 221 caa ttc cca gct gtt ccc ctt gag ccc ctg cct aca act gag ggc aca 48 Gln Phe Pro Ala Val Pro Leu Glu Pro Leu Pro Thr Thr Glu Gly Thr 1 5 10 15 cct gga tta cct ttg cag cag gca gag gag aga tac gag tcg cag gag 96 Pro Gly Leu Pro Leu Gln Gln Ala Glu Glu Arg Tyr Glu Ser Gln Glu 20 25 30 ccc ttg gct gga cag gag tcc cct ctc ccc ctg gct acc agg gag gca 144 Pro Leu Ala Gly Gln Glu Ser Pro Leu Pro Leu Ala Thr Arg Glu Ala 35 40 45 gcc ttg ccc atc ctg gag cca gtc ctg ggg cag gag cag cca gca gcc 192 Ala Leu Pro Ile Leu Glu Pro Val Leu Gly Gln Glu Gln Pro Ala Ala 50 55 60 cct gac cag ccc tgt gtt ctc ttt gct gat gcc cct gag cct gga cag 240 Pro Asp Gln Pro Cys Val Leu Phe Ala Asp Ala Pro Glu Pro Gly Gln 65 70 75 80 gca ctg cct gtt gag gag gag gcc gtg acc cta gcc cgg gct gag acc 288 Ala Leu Pro Val Glu Glu Glu Ala Val Thr Leu Ala Arg Ala Glu Thr 85 90 95 acc caa gcc agg aca gag gct caa gac ttg tgt agg gca tcc ccc gag 336 Thr Gln Ala Arg Thr Glu Ala Gln Asp Leu Cys Arg Ala Ser Pro Glu 100 105 11 0 cct cca ggc cct gaa agc agc tcc cgc tgg ctg gac gac ctc ctg gct 384 Pro Pro Gly Pro Glu Ser Ser Ser Arg Trp Leu Asp Asp Leu Leu Ala 115 120 125 tca cca cca ccc agt ggt ggc ggt gca agg cgg gga gga gct gag 432 Ser Pro Pro Pro Ser Gly Gly Gly Ala Arg Arg Gly Ala Gly Ala Glu 130 135 140 ctg aag gac aca cag tcc cca agt acc tgc tct gag gga ctc ctt ggc 480 Leu Lys Asp Thr Gln Ser Pro Ser Thr Cys Ser Glu Gly Leu Leu Gly 145 150 155 160 tgg tcc cag aaa gat ctg cag agt gaa ttt ggg atc aca gga gac cca 528 Trp Ser Gln Lys Asp Leu Gln Ser Glu Phe Gly Ile Thrhr Gly Asp Pro 165 170 175 cag ccc agc agt ttc agt cct tcc agc tgg tgt caa ggt gct tct cag 576 Gln Pro Ser Ser Phe Ser Pro Ser Ser Trp Cys Gln Gly Ala Ser Gln 180 185 190 gac tat ggc ctt ggg ggt gca agc cct aga gga gac cca ggt ctc gga 624 Asp Tyr Gly Leu Gly Gly Ala Ser Pro Arg Gly Asp Pro Gly Leu Gly 195 200 205 gag agg gac tgg acc agc aag tat ggg caa gga gca ggg gaa ggg agc 672 Glu Arg Asp Trp Thr Ser Lys Tyr Gly Gln Gly Ala Gly Glu Gly S er 210 215 220 acc agg gag tgg gcc agc agg tgt ggc atc ggc cag gag gag atg gag 720 Thr Arg Glu Trp Ala Ser Arg Cys Gly Ile Gly Gln Glu Glu Met Glu 225 230 235 240 gcc agc agc agc caa gac cag agt aaa gtg tct gcc cca ggg gtg ctc 768 Ala Ser Ser Ser Gln Asp Gln Ser Lys Val Ser Ala Pro Gly Val Leu 245 250 255 aca gcc cag gac cgg gta gtt gga aag cca gcc cag ctt ggc act cag 816 Thr Ala Gln Asp Arg Val Val Gly Lys Pro Ala Gln Leu Gly Thr Gln 260 265 270 cgg agc cag gag gca gat gtt cag gac tgg gag ttc aga aag agg gat 864 Arg Ser Gln Glu Ala Asp Val Gln Asp Trp Glu Phe Arg Lys Arg Asp 275 280 285 tcc cag ggc act tac tcc agc cgg gat gca gaa ctc cag gac cag gaa 912 Ser Gln Gly Thr Tyr Ser Ser Arg Asp Ala Glu Leu Gln Asp Gln Glu 290 295 300 ttc gga aag aga gat tca ctg ggt acc tac agt agt cgat agc 960 Phe Gly Lys Arg Asp Ser Leu Gly Thr Tyr Ser Ser Arg Asp Val Ser 305 310 315 320 ctt ggg gac tgg gaa ttt ggg aag aga gat tct ctg ggt gct tat gcc 1008 Leu Gly Asp Trp Glu Phe Gly Lys Arg Asp SerLeu Gly Ala Tyr Ala 325 330 335 agc caa gat gcc aac gag cag ggc cag gat ttg ggg aag agg gac cac 1056 Ser Gln Asp Ala Asn Glu Gln Gly Gln Asp Leu Gly Lys Arg Asp His 340 345 350 350 cat ggt agg tac agc cag gat gcc gat gag cag gac tgg gag ttt 1104 His Gly Arg Tyr Ser Ser Gln Asp Ala Asp Glu Gln Asp Trp Glu Phe 355 360 365 cag aag aga gat gtg tca ctc ggc acc tat ggc agc cgg gct gcg gag Arg 1152 Gln Lys Asp Val Ser Leu Gly Thr Tyr Gly Ser Arg Ala Ala Glu 370 375 380 cca cag gaa cag gag ttt ggg aag agc gct tgg ata agg gac tac agc 1200 Pro Gln Glu Glu Gln Glu Phe Gly Lys Ser Ala Trp Ile Arg Asp Tyr Ser 385 390 395 400 agt ggt ggc agc tcc agg acc ctt gac gcc cag gac aga agc ttt gga 1248 Ser Gly Gly Ser Ser Arg Thr Leu Asp Ala Gln Asp Arg Ser Phe Gly 405 410 415 acg aga ccc ctg agc tct ggg ttc agc gcc gaa gcc cag caa cag 1296 Thr Arg Pro Leu Ser Ser Gly Phe Ser Pro Glu Glu Ala Gln Gln Gln 420 425 430 gat gag gaa ttt gag aag aag att cca agt gtg gaa gac agc ctt gga 1344 Asp Glu Glu Phe Glu Lys L ys Ile Pro Ser Val Glu Asp Ser Leu Gly 435 440 445 gag ggc agc agg gat gct ggc cgg cca gga gag aga gga tcc ggg ggc 1392 Glu Gly Ser Arg Asp Ala Gly Arg Pro Gly Glu Arg Gly Ser Gly Gly 450 455 460 460 ttg ttc agt cct agc act gcc cac gtg ccg gat ggg gca ctc ggg cag 1440 Leu Phe Ser Pro Ser Thr Ala His Val Pro Asp Gly Ala Leu Gly Gln 465 470 475 475 480 aga gac cag agc agc tgg caa aac agt gat gct agc cag gtg gga 1488 Arg Asp Gln Ser Ser Trp Gln Asn Ser Asp Ala Ser Gln Glu Val Gly 485 490 495 ggg cat cag gag aga cag cag gca ggg gct cag ggc cct ggc agt gct 1536 Gly His Gln Glu Arg Gln Gln Ala Gly Ala Gln Gly Pro Gly Ser Ala 500 505 510 gac ctg gaa gat ggg gag atg gga aag cga ggc tgg gtc ggt gag ttt 1584 Asp Leu Glu Asp Gly Glu Met Gly Lys Arg Gly Trp Val Gly Glu Phe 515 520 525 agc ctc cgt cag cga gag gca gca ttt agc cca ggg cag 1632 Ser Leu Ser Val Gly Pro Gln Arg Glu Ala Ala Phe Ser Pro Gly Gln 530 535 540 cag gac tgg agc cgg gac ttc tgc atc gag gcc agt gag agg agc tat 1680 Gln As p Trp Ser Arg Asp Phe Cys Ile Glu Ala Ser Glu Arg Ser Tyr 545 550 555 560 cag ttt ggc atc att ggc aac gac aga gtg agt ggt gct ggc ttt agc 1728 Gln Phe Gly Ile Ile Gly Asn Asp Arg Val Ser Gly Ala Phe Ser 565 570 575 cct tct agc aag atg gaa ggt ggt cac ttt gtg cct cct ggg aag acc 1776 Pro Ser Ser Lys Met Glu Gly Gly His Phe Val Pro Pro Gly Lys Thr 580 585 590 aca gct ggc tcg gtg gac tgg act gac cag ctg ggt ctc agg aac ttg 1824 Thr Ala Gly Ser Val Asp Trp Thr Asp Gln Leu Gly Leu Arg Asn Leu 595 600 605 gaa gtg tcc agc tgt gtg ggt tct ggg ggc tcg agc gag gcc agg gag 1872 Glu Val Ser Gly Ser Gly Gly Ser Ser Glu Ala Arg Glu 610 615 620 agt gcc gtg gga cag atg ggc tgg tca ggt ggc ctg agc ttg aga gac 1920 Ser Ala Val Gly Gln Met Gly Trp Ser Gly Gly Leu Ser Leu Arg Asp 640 630 635 atg aac ctg acc ggc tgt ttg gaa agt gga ggg tct gaa gag ccg ggg 1968 Met Asn Leu Thr Gly Cys Leu Glu Ser Gly Gly Ser Glu Glu Pro Gly 645 650 655 gga atc gga gtt ggg gag aag gac tgg act tct gat aat gtg aag 2016 Gly Ile Gly Val Gly Glu Lys Asp Trp Thr Ser Asp Val Asn Val Lys 660 665 670 agc aaa gat ttg gct gag gtc ggg gag gga gga ggc cac agc cag gcc 2064 Ser Lys Asp Leu Ala Glu Val Gly Glu Glu Gly Gly His Ser Gln Ala 675 680 685 aga gag agt ggc gtg ggg cag act gac tgg tca ggt gtg gag gcc gga 2112 Arg Glu Ser Gly Val Gly Gln Thr Asp Trp Ser Gly Val Glu Ala Gly 690 695 700 gag ttc ctt aaa tca agg gag cgt gga gtt gga cag gca gac tgg aca 2160 Glu Phe Leu Lys Ser Arg Glu Arg Gly Val Gly Gln Ala Asp Trp Thr 705 710 715 720 cct gac ctt ggg ctg aga aac atg gcc cca ggg gca gtc tgc agt cct 2208 Asp Leu Gly Leu Arg Asn Met Ala Pro Gly Ala Val Cys Ser Pro 725 730 735 gga gag tcc aaa gag ctt ggg gtg ggc cag atg gac tgg ggt aac aat 2256 Gly Glu Ser Lys Glu Leu Gly Val Gly Gln Met Asp Trp Gly Asn Asn 740 745 750 ctg ggc ctg agg gat ttg gag gtg acc tgt gac cca gac tct gga ggt 2304 Leu Gly Leu Arg Asp Leu Glu Val Thr Cys Asp Pro Asp Ser Gly Gly 755 760 765 tct cag ggg cta cgg gga tgt gga gtg ggg cag atg gac tgg acc cag 2352 Ser Gln Gly Leu Arg Gly Cys Gly Val Gly Gln Met Asp Trp Thr Gln 770 775 780 gac ttg gcg ccc cag aat gtg gag ctc ttt ggg gct cca agt gaa gcc 2400 Asp Leu Ala Asn Val Glu Leu Phe Gly Ala Pro Ser Glu Ala 785 790 795 800 agg gag cat ggg gtg ggc ggg gtg agc cag tgc cca gag ccc ggc ctg 2448 Arg Glu His Gly Val Gly Gly Val Ser Gln Cys Pro Glu Pro Gly Leu 805 810 815 agg cac aat ggc agc ttg tct cct ggc ctg gag gcc aga gac ccc ttg 2496 Arg His Asn Gly Ser Leu Ser Pro Gly Leu Glu Ala Arg Asp Pro Leu 820 825 830 gag gcc agg gag ctg ggg gtt ggt gag acagt gag acc cag 2544 Glu Ala Arg Glu Leu Gly Val Gly Glu Thr Ser Gly Pro Glu Thr Gln 835 840 845 ggt gaa gat tac tcc tcg tct tcc ttg gag cca cac cct gca gac cct 2592 Gly Glu Asp Tyr Ser Ser Ser Ser Leu Glu Pro His Pro Ala Asp Pro 850 855 860 gga atg gag aca gga gaa gcc ctc agc ttc gga gca agc cct ggc agg 2640 Gly Met Glu Thr Gly Glu Ala Leu Ser Phe Gly Ala Ser Pro Gly Arg 865 870 875 875 880 tgc ccg cc cgc ccc cca ccc tcc ggc tcc cag ggc ctg ctg gag gag 2688 Cys Pro Ala Arg Pro Pro Ser Gly Ser Gln Gly Leu Leu Glu Glu 885 890 895 atg ctg gca gcc agc agc tcc aag gcg gtg ggg cgg agg 2736 Met Leu Ala Ala Ser Ser Ser Lys Ala Val Ala Arg Arg Glu Ser Ala 900 905 910 gcc tcg ggc ctt ggg ggc ctg ttg gag gag gaa gga gcc ggg gca ggt 2784 Ala Ser Gly Leu Gly Gly Leu Leu Glu Glu Glu A Gly Ala Gly 915 920 925 gct gcc caa gag gag gtg ctg gag cct ggc agg gac tct cca ccc tcc 2832 Ala Ala Gln Glu Glu Val Leu Glu Pro Gly Arg Asp Ser Pro Pro Ser 930 935 940 tgg agg ccg cag cct gat ggt gcc agc cag aca gaa gac gtg gat 2880 Trp Arg Pro Gln Pro Asp Gly Glu Ala Ser Gln Thr Glu Asp Val Asp 945 950 955 960 ggc acc tgg ggc tct tca gca gcc agg tgg agc gat cag ggg cca gca 2928 Gly Thrp Ser Ser Ala Ala Arg Trp Ser Asp Gln Gly Pro Ala 965 970 975 cag act tct cgg cga ccc tcc caa ggc cct cct gcc aga tcc ccc agt 2976 Gln Thr Ser Arg Arg Pro Ser Gln Gly Pro Pro Ala Arg Ser Pro Ser 98 0 985 990 cag gac ttc tcc ttc att gag gac acc gag atc ctc gac agt gcc atg 3024 Gln Asp Phe Ser Phe Ile Glu Asp Thr Glu Ile Leu Asp Ser Ala Met 995 1000 1005 tat cgg agc cgt gcc aac ttg ggg cgag ag ggg cac cgg gcc ccg 3072 Tyr Arg Ser Arg Ala Asn Leu Gly Arg Lys Arg Gly His Arg Ala Pro 1010 1015 1020 gtc att cgg cct ggg ggt acc ttg ggc ctg tcg gag gca gca gac tcg 3120 Val Ile Arg Pro Gly Thry Gly Leu Ser Glu Ala Ala Asp Ser 1025 1030 1035 1040 gat gca cac ctg ttc cag gac tct aca gag cca cgg gca tct cgg gtg 3168 Asp Ala His Leu Phe Gln Asp Ser Thr Glu Pro Arg Ala Ser Arg Val 1045 1050 1055 cca tct tca gat gaa gag gta gtg gag gaa cct cag agc cgc cgg aca 3216 Pro Ser Ser Asp Glu Glu Val Val Glu Glu Pro Gln Ser Arg Arg Thr 1060 1065 1070 cgg atg tcg ttg ggc acc aag ggg ctg aaa gtc cac ctc ttt 3264 Arg Met Ser Leu Gly Thr Lys Gly Leu Lys Val Asn Leu Phe Pro Gly 1075 1080 1085 ctg agc ccc tca gcc ctg aag gcc aag ctg cgc ccc cgg aat cgc tca 3312 Leu Ser Pro Ser Ala Leu Lys Ala Lys Leu Arg Pro Arg Asn Arg Ser 1090 1095 1100 gct gag gag gga gag ctg gct gag agc aag tcg agc cag aag gag tcc 3360 Ala Glu Glu Gly Glu Leu Ala Glu Ser Lys Ser Ser Gln Lys Glu Ser 1105 1110 1115 1120 g gtc cag cgt tcg aaa tcc tgc aag gtc cca gga ctg gga aag ccc 3408 Ala Val Gln Arg Ser Lys Ser Cys Lys Val Pro Gly Leu Gly Lys Pro 1125 1130 1135 ctc acg tta cct ccc aag cca gag aaa tcc tca ggg tca ga tcg 3456 Leu Thr Leu Pro Pro Lys Pro Glu Lys Ser Ser Gly Ser Glu Gly Ser 1140 1145 1150 tcg ccc aac tgg ctt caa gcc ctg aaa ctg aag aag aag aag aag gtc 3501 Ser Pro Asn Trp Leu Gln Ala Leu Lys Leu Lys Lys Lys Lys Val 1155 1160 1165 tgagaagtca ctgaggttct tcccacctgg cagtctcagg cagtgcccat tcctgtgggg 3561 tccctgggtg aggagacggc tggagcccca ccatgcccca ggctgcagcc tctgtcccct 3621 ccacctctga ggagcgtctg gggaggcaca tttatgcact ttgtatcacc ctccgaactc 3681 cccccacacc ttcccttccc tggatttcat cactagtggt tgaaggtttt gtcccttcct 3741 ctcctccttc cctctccctc tctgcttcct cctccagcct cccttgggtt ttcttttgat 3801 acca atttat agcatttttt ataaaagcct ttgattttta taatgggtgg gactgtatcc 3861 ctgcctcacc ccaggtctcc gtctgccccg ccaggtaccc cacagagacc aatgacattt 3921 tgccacttga aacaataaat aaagtttttt gggaattggt 3961 <210> 222 <211> 4305 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (3565) <400> 222 g tta gtg gtc tgg aga gca cta caa gcc ctc aca ggc ccc agg aag ctg 49 Leu Val Val Trp Arg Ala Leu Gln Ala Leu Thr Gly Pro Arg Lys Leu 1 5 10 15 ctt ttc ctt tcc cca gac ctt gag ctg aac agc tcg agc tcc cac aac 97 Leu Phe Leu Ser Pro Asp Leu Glu Leu Asn Ser Ser Ser Ser His Asn 20 25 30 act ctg agg cct gca ccc aga ggc agt gcc cag gag agc gct gtc cgg 145 Thr Leu Arg Pro Ala Pro Arg Gly Ser Ala Gln Glu Ser Ala Val Arg 35 40 45 cct cgg aga atg gtg gag ccc ctg gag gac aga agg caa gag aac ttc 193 Pro Arg Arg Met Val Glu Pro Leu Glu Asp Arg Arg Gln Glu Asn Phe 50 55 60 ttc tgt ggc ccc cct gag aag agc tat gca aag ctg gtg ttc atg tcc 241 Phe Cys Gly Pro Pro Glu Lys Ser Tyr Ala Lys Leu Val Phe Met Ser 65 70 75 80 acc tcc tcg ggc agc cta tgg aac ctg cat gcc atc tcc atg tgt 289 Thr Ser Ser Gly Ser Leu Trp Asn Leu His Ala Ile His Ser Met Cys 85 90 95 cgc atg gaa cag gac cag atc cgc tcc cat acc agc ttc ggg gct ctg 337 Arg Met Glu Gln Asp Gln Ile Arg Ser His Thr Ser Phe Gly Ala Leu 100 105 110 tgc cag cgg aca gca gcc aac cag tgc tgc ccc agc tgg tcc ctg ggc 385 Cys Gln Arg Thr Ala Ala Asn Gln Cys Cys Pro Ser Trp Ser Leu Gly 115 120 125 aac tat ctg gct gtg ctc tcc aac tgc tcc gac act acc 433 Asn Tyr Leu Ala Val Leu Ser Asn Arg Ser Ser Cys Leu Asp Thr Thr 130 135 140 caa gct gac gca gcc cgc aca ctg gcc ctg ctt cgg acc tgt gcc ctc 481 Gln Ala Asp Ala Ala Arg Thr Leu Ala Leu Leu Arg Thr Cys Ala Leu 145 150 155 160 tac tac cac agt ggc gcc ttg gtg ccc tct tgt ctg gga cct ggg cag 529 Tyr Tyr His Ser Gly Ala Leu Val Pro Ser Cys Leu Gly Pro Gly Gln 165 170 175 aac aag tcc cca cgc tgt gcc cag gtt ccc acc aag tgc tcc cag agt 577 Asn Lys Ser Pro Arg Cys Ala Gln Val Pro Thr Lys Cys Ser Gln Ser 180 185 190 agt gcc atc tac caa ctc ctg cac ttt ctg ctt gac agg gac ttt ctg 625 Ser Ala Ile Tyr Gln Leu Leu His Phe Leu Leu Asp Arg Asp Phe Leu 195 200 205 agt ccc cag acc act gac tac cag gtg cct tcc ctc aag tac agc ctg 673 Ser Pro Gln Thr Thr Asp Tyr Gln Val Pro Ser Leu Lys Tyr Ser Leu 210 215 220 ctc ttc ctg ccc acc cca aag ggt gct tcc ctc atg gac atc tac ctg 721 Leu Phe Leu Pro Thr Pro Lys Gly Ala Ser Leu Met Asp Ile Tyr Leu 225 230 235 235 240 gac cgg ctg gcc acc ccc tgg ggg ctt gct gac aac tac acc tct gtc 769 Asp Arg Leu Ala Thr Pro Trp Gly Leu Ala Asp Asn Tyr Thr Ser Val 245 250 255 act ggc atg gac ctg ggc ctc aag cag gag ctg ctg agg cac ttc ctg 817 Thr Gly Met Asp Leu Leu Lys Gln Glu Leu Leu Arg His Phe Leu 260 265 270 gtc cag gac acg gtg tac ccc ttg ctg gct ctg gtt gcc atc ttc ttc 865 Val Gln Asp Thr Val Tyr Pro Leu Leu Ala Leu Val Ala Ile Phe Phe gg 280 280 atg gcc ctg tac ctg cgc tca ctc ttc ctc acg ctc atg gtg ctg 913 Gly Met Ala Leu Tyr Leu Arg Ser Leu Phe Leu Thr Leu Met Val Leu 290 295 300 ctg ggg gtg ctg ggc tca ctg cct ggt 961 Leu Gly Val Leu Gly Ser Leu Leu Val Ala Phe Phe Leu Tyr Gln Val 305 310 315 320 gcc ttc cgc atg gcc tac ttc ccc ttc gtc aat ctg gca gcc ctc ctc 1009 Ala Phe Arg Met Ala Tyr Phe Pro sn Leu Ala Ala Leu Leu 325 330 335 ctg ctg agc agc gtc tgc gcc aac cac acg ctc atc ttc ttc gac ctg 1057 Leu Leu Ser Ser Val Cys Ala Asn His Thr Leu Ile Phe Phe Asp Leu 340 345 350 tgg cgcg agc cag ctg ccg tcg ggg ggg ctg gcg cag cgc 1105 Trp Arg Leu Ser Lys Ser Gln Leu Pro Ser Gly Gly Leu Ala Gln Arg 355 360 365 gtg ggc cgc acc atg cac cac ttc ggc tac ctg ctg ctg gtg ctg gtg ctg ctg ctg ctg ctg gg Arg Thr Met His His Phe Gly Tyr Leu Leu Leu Val Ser Gly 370 375 380 ctc acc acg agc gcg gcc ttc tat gcc agc tac ctg agc cgc ctg ccg 1201 Leu Thr Thr Ser Ala Ala Phe Tyr Ala Ser Tyr Leu Ser Arg Leu 385 390 395 400 gcc gtt cgc tgc ctc gcc ctc ttc atg ggc acg gct gtg ctg gtg cac 1249 Ala Val Arg Cys Leu Ala Leu Phe Met Gly Thr Ala Val Leu Val His 405 410 415 ct ctg gcg ctc cg ctg gtg ctg tcc gcc gtg ctc cac gag 1297 Leu Ala Leu Thr Leu Val Trp Leu Pro Ala Ser Ala Val Leu His Glu 420 425 430 cgc tac ctg gcg cgc ggc tgt gcg cgc cgg gcg cgg ggc cgg tgg gag 1345 Arg Tyr Leu A y Cys Ala Arg Arg Ala Arg Gly Arg Trp Glu 435 440 445 ggc agc gcg ccc cgg cgg cta ctg ctg gcg ctg cac cgg cgg ctc cgc 1393 Gly Ser Ala Pro Arg Arg Leu Leu Leu Ala Leu His Arg Arg 460 Arg ggc ctg cgg agg gcg gcg gct ggc acc tcg cgt ctg ctc ttc cag cgc 1441 Gly Leu Arg Arg Ala Ala Ala Gly Thr Ser Arg Leu Leu Phe Gln Arg 465 470 475 480 ctg ctg ccc tcc gc gc gtc cc cc cc cc cc cc cc cc cc cc cc gc gtc atc gc gtc ggc gtc atc tgc tgg 1489 Leu Leu Pro Cys Gly Val Ile Lys Phe Arg Tyr Ile Trp Ile Cys Trp 485 490 495 ttc gca gca ctg gcg gca ggg ggc gcc tac atc gcc gga gtc agc ccc 1537 Phe Ala Ala Tla Ile Ala Gly Val Ser Pro 500 505 510 cgc ctg cgg ctg ccc acg ctg ccg ccg ccc ggc ggc cag gtc ttc cgg 1585 Arg Leu Arg Leu Pro Thr Leu Pro Pro Pro Gly Gly Gln Val Phe Arg 515 520 525 ccc agc cac gag cgc ttc gac gca gag tat cgc cag ctg ttc 1633 Pro Ser His Pro Phe Glu Arg Phe Asp Ala Glu Tyr Arg Gln Leu Phe 530 535 540 ctg ttc gag cag ctg ccg cag ggc gag ggc ggc Lec gat ccc u Phe Glu Gln Leu Pro Gln Gly Glu Gly Gly His Met Pro Val Val 545 550 555 560 ttg gtg tgg ggc gtc ctg cct gtg gac act ggc gac cct ctg gac cct 1729 Leu Val Trp Gly Val Leu Pro Val Asp Thr Gly Asp Pro Leu Asp Pro 565 570 575 cgt agc aac agcc agc ctg gtg agg gac cct gcc ttc tcg gcc agc ggc 1777 Arg Ser Asn Ser Ser Leu Val Arg Asp Pro Ala Phe Ser Ala Ser Gly 580 585 590 590 cct gag gcc cag cgcgg gca ctc tgt cac cgg gcc cgg aat 1825 Pro Glu Ala Gln Arg Trp Leu Leu Ala Leu Cys His Arg Ala Arg Asn 595 600 605 cag agc ttc ttc gac acc ctg cag gaa ggc tgg ccc acg ctg tgt ttc 1he Gln Thr Leu Gln Glu Gly Trp Pro Thr Leu Cys Phe 610 615 620 gtg gag acc ctc cag cgc tgg atg gag agc ccc agc tgc gcc cgc ctg 1921 Val Glu Thr Leu Gln Arg Trp Met Glu Ser Pro Ser Cys Ala Arg Leu 630 630 640 ggg cct gac ctc tgc tgc ggc cac tcg gac ttc ccc tgg gcc ccc cag 1969 Gly Pro Asp Leu Cys Cys Gly His Ser Asp Phe Pro Trp Ala Pro Gln 645 650 655 ttt ttc ctg cac tgc ctg atg atg atg caa ggc ccc gat 2017 Phe Phe Leu His Cys Leu Lys Met Met Ala Leu Glu Gln Gly Pro Asp 660 665 670 ggc acc cag gac ctg gga ctc cgc ttt gat gcc cat ggc agc ctg gcc 2065 Gly Thr Gln Asp Leg Gly Asp Ala His Gly Ser Leu Ala 675 680 685 gcc ctg gtc cta caa ttc cag acc aac ttc cgg aac agt ccg gac tac 2113 Ala Leu Val Leu Gln Phe Gln Thr Asn Phe Arg Asn Ser Pro Asp Tyr 690 695 700 aac cag acc cag ctc ttc tac aat gag gtc agc cac tgg ctg gca gcg 2161 Asn Gln Thr Gln Leu Phe Tyr Asn Glu Val Ser His Trp Leu Ala Ala 705 710 715 720 gag ctg ggc atg gca cct cca ggc ctc cgc cgt ggt ggt Glu Leu Gly Met Ala Pro Pro Gly Leu Arg Arg Gly Trp Phe Thr Ser 725 730 735 cgt cta gag ctg tat agc ctg cag cac agc ctg agc act gag cct gct 2257 Arg Leu Glu Leu Tyr Ser Leu Gln His Ser Leu Ser Thr Glu Pro Ala 740 745 750 gtg gtg ctg ggc ctg gct ttg gcg ctg gcc ttt gcc aca ctg ctc ctg 2305 Val Val Leu Gly Leu Ala Leu Ala Leu Ala Phe Ala Thr Leu Leu Leu 755 760 765 ggc acc tgg ag agc cta ttc tcc gtg gca gct gtg gca 2353 Gly Thr Trp Asn Val Pro Leu Ser Leu Phe Ser Val Ala Ala Val Ala 770 775 780 ggc acc gtg ctg ctc act gta gga ctc ctg gtt ctc ctc gag tgg Leg 2401 Gly Leu Thr Val Gly Leu Leu Val Leu Leu Glu Trp Gln 785 790 795 800 ctc aac act gcc gag gcc ctg ttt ctc tct gcc tca gtg ggc ctc tca 2449 Leu Asn Thr Ala Glu Ala Leu Phe Leu Ser Ala Ser Val Gly Leu Ser 805 810 815 gta gac ttc act gtc aac tac tgc atc tcc tat cac ctg tgc cca cac 2497 Val Asp Phe Thr Val Asn Tyr Cys Ile Ser Tyr His Leu Cys Pro His 820 825 830 cct gac cgc ctg agc cgt gtc tc tc cag acc agc tgc 2545 Pro Asp Arg Leu Ser Arg Val Ala Phe Ser Leu Arg Gln Thr Ser Cys 835 840 845 gcc aca gcc gtg ggg gct gca gcc ctg ttt gcg gca ggc gtg ctc atg 2593 Ala Thr Ala Val Gly Ala Ala Ala Phe Ala Ala Gly Val Leu Met 850 855 860 ctg cct gcc aca gtg ctg ctc tat cgc aag ctg ggc atc atc ctc atg 2641 Leu Pro Ala Thr Val Val Leu Leu Tyr Arg Lys Leu Gly Ile Ile Leu Met 865 870 875 880 tc aaa tgc gtc agt tgt ggc ttt gcc agc ttc ttc ttc caa tct 2689 Met Val Lys Cys Val Ser Cys Gly Phe Ala Ser Phe Phe Phe Gln Ser 885 890 895 ctc tgc tgt ttc ttc ggg cca gag aag aggt tgg 2737 Leu Cys Cys Phe Phe Gly Pro Glu Lys Asn Cys Gly Gln Ile Leu Trp 900 905 910 ccc tgt gcc cac ctg cca tgg gat gct ggt act ggg gac cct ggt ggg 2785 Pro Cys Ala His Leu Pro Trp Asp Ala Gly Thr Gly Asp Pro Gly Gly 915 920 925 gag aag gca ggc cgc cca cga cca ggg tca gtg gga ggg atg ccc ggg 2833 Glu Lys Ala Gly Arg Pro Arg Pro Gly Ser Val Gly Gly Met Pro Gly 930 935 940 tcc tgc tca gag tat gag cta cag ccc ctg gca cgg cgt cgg agc 2881 Ser Cys Ser Glu Gln Tyr Glu Leu Gln Pro Leu Ala Arg Arg Arg Ser 945 950 955 960 ccc agc ttt gac acc agc aca gcc acc agc aag ctg tcc cac cgg ccc 2929 Pro Ser Phe Asp Thr Ser Thr Ala Thr Ser Lys Leu Ser His Arg Pro 965 970 975 tca gta ctc tct gag gat ctg cag ctc cat gat ggt ccg tgc tgt tcc 2977 Ser Val Leu Ser Glu Asp Leu Gln Leu His Asp Gly Pro Cys Cys S er 980 985 990 cgg ccc cca cca gcc cct gcc tcc cca agg gag ctg ctg ctg gac cac 3025 Arg Pro Pro Pro Ala Pro Ala Ser Pro Arg Glu Leu Leu Leu Asp His 995 1000 1005 cag gca gtc ttc agc cag tgc cct gcc cag acc tcc tcc ccc tat 3073 Gln Ala Val Phe Ser Gln Cys Pro Ala Leu Gln Thr Ser Ser Pro Tyr 1010 1015 1020 aag cag gct ggc ccc agc ccc aaa acc cgg gcc agg cag gac tcc caa 3121 Lys Gln Ala Gly Pro Ser Pro Lys Thr Arg Ala Arg Gln Asp Ser Gln 1025 1030 1035 1040 ggg gag gag gct gag ccc ctg cca gcc tca cca gaa gcc cca gcc cac 3169 Gly Glu Glu Ala Glu Pro Leu Pro Ala Ser Pro Glu Ala Pro Ala His 1045 1050 1055 tct cct aag gcc aag gct gca gat cct cct gat ggc ttc tgt tcc tca 3217 Ser Pro Lys Ala Lys Ala Ala Asp Pro Pro Asp Gly Phe Cys Ser Ser 1060 1065 1070 gcc agc acc ctg gag ggg ctc agc gtc tct gat gag acct agc 3265 Ala Ser Thr Leu Glu Gly Leu Ser Val Ser Asp Glu Thr Cys Leu Ser 1075 1080 1085 acc tct gag ccc agt gcc cgt gta cca gat tcc gtg ggt gtg tcc cca 3313 Thr Ser Glu Pro Ser Ala Arg Val Pro Asp Ser Val Gly Val Ser Pro 1090 1095 1100 gat gac ctg gat gac act ggg cag cca gtc ctt gag cga ggc cag ctc 3361 Asp Asp Leu Asp Asp Thr Gly Gln Pro Val Leu Glu Arg Gly Gln Leu 1105 1110 1115 1115 1120 aat ggg aag cgg gac acc ctg tgg ctg gcg ctg agg gag aca gtg tat 3409 Asn Gly Lys Arg Asp Thr Leu Trp Leu Ala Leu Arg Glu Thr Val Tyr 1125 1130 1135 gac cca tca ttg ccc gct tcc cat cac agc tc cat aag ggc 3457 Asp Pro Ser Leu Pro Ala Ser His His Ser Ser Leu Ser Trp Lys Gly 1140 1145 1150 cga ggg ggg cca ggg gat ggc agc cct gtg gtg ctg ccc aat agc cag 3505 Arg Gly Gly Pro Gly Asp Gly Ser Pro Val Val Leu Pro Asn Ser Gln 1155 1160 1165 cca gac ctg cca gat gtt tgg ctg cgc agg ccc agc act cac acg tca 3553 Pro Asp Leu Pro Asp Val Trp Leu Arg Arg Pro Ser Thr His Thr Ser 1170 1175 1180 ggc tat agc agc tgagggggac tggacagggc gcggaaccct 3605 Gly Tyr Ser Ser 1185 gtcatggatg acaaggcaag ggcagcaata ggctggagcc cgaaggtatt tctccagatc 3665 cacagggaga ggtctcaccc tccagctgtg gatgttaaa c cctgccagat gtcccagcct 3725 tgatctgtct gctcctactc ctcacatctg gaggattcca gcaggagggg ttttggaggg 3785 gacctgcttg cgacctgctg agggcttgtc tgctcccaca gcaccatcta agacccctcc 3845 tctagaagtg gggaaggcca gatgtgtagc ttcgggtatc agaggaggct gacctggccc 3905 ccatcccaag ttacaagaac ttcagtgaga ctaagggacc cccatcctag ggatcttgtc 3965 agggttcctt actgaccaga ggagcccgca gcaatctcca cagcctcctg ggtctcaccc 4025 ctttcatggg ctcttcatca ggacacttcc ctctcttttg ggagcttctc tgggcagaat 4085 tgggctggga cctctctccc caactgccct gctctcctca tactcaccgg tttgaccaga 4145 aattctccaa atccagccat agatggctgc tgggtgtgca gcaggagaag gaggatggtc 4205 agccttggag catctctcaa ttacgggaca gtccctcttt ggaagcaggc tcctgtggtt 4265 tcctgatcatcattgattcatg <210> 223 <211> 3790 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (1804) <400> 223 g aac ctg gcc aac ttt gcc aaa ttt ggc agc aag gag gaa tac atg tcc 49 Asn Leu Ala Asn Phe Ala Lys Phe Gly Ser Lys Glu Glu Tyr Met Ser 1 5 10 15 ttc atg aac cag ttc cta gag cat gag tgg acc aac atg cag cgc ttc 97 Phe Met Asn Gln Phe Leu Glu His Glu Trp Thr Asn Met Gln Arg Phe 20 25 30 ctg ctg gag atc tcc aac ccc gag acc ctc tcc aat aca gcc ggc ttc 145 Leu Leu Glu Ile Ser Asn Pro Glu Thr Leu Ser Asn Thr Ala Gly Phe 35 40 45 gag ggc tac atc gac ctg ggc cgc gag ctc tcc agc ctg cac tca ctg 193 Glu Gly Tyr Ile Asp Leu Gly Arg Glu Leu Ser Ser Leu His Ser Leu 50 55 60 ctc tgg gag gcc gtc agc cag ctg gag cag agc ata gta tcc aaa ctg 241 Leu Trp Glu Ala Val Ser Gln Leu Glu Gln Ser Ile Val Ser Lys Leu 65 70 75 80 gga ccc ctg cct cgg atc ctg agg gac gtc cacca ctg agc acc 289 Gly Pro Leu Pro Arg Ile Leu Arg Asp Val His Thr Ala Leu Ser Thr 85 90 95 cca ggt agc ggg cag ctc cca ggg acc aat gac ctg gcc tcc aca ccg 337 Pro Gly Ser Gly Gln Leu Pro Gly Thr Asn Asp Leu Ala Ser Thr Pro 100 105 110 ggc tct ggc agc agc agc atc tca gct ggg ctg cag aag atg gtg att 385 Gly Ser Gly Ser Ser Ser Ile Ser Ala Gly Leu Gln Lys Met Val Ile 115 120 125 gag aac gat ctt tcc ggt ctg ata gat ttc acc cgg ttac ccg tct cca 433 Glu Asn Asp Leu Ser Gly Leu Ile Asp Phe Thr Arg Leu Pro Ser Pro 130 135 140 acc ccc gaa aac aag gac ttg ttt ttt gtc aca agg tcc tcc ggg gtc 481 Thr Pro Glu Asn Lys Asp Leu Phe Phe Val Thr Arg Ser Ser Gly Val 145 150 155 160 cag ccc tca cct gcc cgc agc tcg agt tac tcg gaa gcc aac gag cct 529 Gln Pro Ser Pro Ala Arg Ser Ser Ser Tyr Ser Glu Ala Asn Glu Pro 165 170 175 gat ctt cag atg gcc aac ggt ggc aag agc ctc tcc atg gtg gac ctc 577 Asp Leu Gln Met Ala Asn Gly Gly Lys Ser Leu Ser Met Val Asp Leu 180 185 190 cag gac gcc cgc acg ctg gat ggg gag gca ggc tcc ccg gcg ccg gcc Asp Ala Arg Thr Leu Asp Gly Glu Ala Gly Ser Pro Ala Gly Pro 195 200 205 gac gtc ctc ccc aca gat ggg cag gcc gct gca gct cag ctg gtg gcc 673 Asp Val Leu Pro Thr Asp Gly Gln Ala Ala Ala Ala Ala Gln Leu Val Ala 210 215 220 ggg tgg ccg gcc cgg gca acc cca gtg aac ctg gca ggg ctg gcc acg 721 Gly Trp Pro Ala Arg Ala Thr Pro Val Asn Leu Ala Gly Leu Ala Thr 225 230 235 240 gtg cgg cgg gca ggc cag aca cca acc aca cca ggc acc tcc gag ggc 769 Val Arg Arg Ala Gly Gln Thr Pro Thr Thr Pro Gly Thr Ser Glu Gly 245 250 255 gcg cca ggc cgg ccc cag ctg ttg gca ccg ctc tcc ttc cag aac cct 817 Ala Pro Gly Arg Pro Gln Leu Leu Ala Pro Leu Ser Phe Gln Asn Pro 260 265 270 gtg tac cag atg gcg gct ggc ctg ccg ctg tca ccc cgt ggc ctt ggc 865 Val Tyr Gln Met Ala Ala Gly Leu Pro Leu Ser Pro Arg Gly Leu Gly g 275 280 280 tca ggc tct gag ggc cac agc tcc ctg agc tca cac agc aac agc 913 Asp Ser Gly Ser Glu Gly His Ser Ser Leu Ser Ser His Ser Asn Ser 290 295 300 gag gag ttg gcg gct gct gcc aag ctg gga agt ttc ag act gcg 961 Glu Glu Leu Ala Ala Ala Ala Lys Leu Gly Ser Phe Ser Thr Ala Ala 305 310 315 320 gag gag ctg gct cgg cgg ccc ggt gag ctg gca cgg cga cag atg tca 1009 Glu Glu Leu Ala Arg Arg Pro Gly Glu Leu Al a Arg Arg Gln Met Ser 325 330 335 ctg act gaa aaa ggc ggg cag ccc acg gtg cca cgg cag aac agt gct 1057 Leu Thr Glu Lys Gly Gly Gly Gln Pro Thr Val Pro Arg Gln Asn Ser Ala 340 345 345 350 ggc ccc cag agg agg atc gac cag cct ccg ccc cca ccc ccg ccg cca 1105 Gly Pro Gln Arg Arg Ile Asp Gln Pro Pro Pro Pro Pro Pro Pro Pro 355 360 365 cct cct gcc ccc cgc ggc cgg acg ccc ccc aac ctg ctg agc acc ctg 1153 Pro Pro Ala Pro Arg Gly Arg Thr Pro Pro Asn Leu Leu Ser Thr Leu 370 375 380 cag tac cca aga ccc tca agc gga acc ctg gcg tcg gcc tca cct gat 1201 Gln Tyr Pro Arg Pro Ser Ser Gly Thr Leu Ala Ser Ala Ser Pro Asp 385 390 395 400 tgg gtg ggc ccc agt acc cgc ctg agg cag cag tcc tct tcc tcc aag 1249 Trp Val Gly Pro Ser Thr Arg Leu Arg Gln Gln Ser Ser Ser Ser Lys 405 410 415 ggg gac agc cca gaa ctg aag cca cgg gca gtg cac aag cag ggc cct 1297 Gly Asp Ser Pro Glu Leu Lys Pro Arg Ala Val His Lys Gln Gly Pro 420 425 430 tca cct gtg agc ccc aat gcc ctg gac cgc aca gcc gct tgg ctc ttg 1345 Ser Pro Val Ser Pro As n Ala Leu Asp Arg Thr Ala Ala Trp Leu Leu 435 440 445 acc atg aac gcg cag ttg tta gaa gac gag ggc ctg ggc cca gac ccc 1393 Thr Met Asn Ala Gln Leu Leu Glu Asp Glu Gly Leu Gly Pro Asp Pro 450 455 ccc cac agg gat agg cta agg agt aag gac gag ctc agc caa gca gaa 1441 Pro His Arg Asp Arg Leu Arg Ser Lys Asp Glu Leu Ser Gln Ala Glu 465 470 475 475 480 aag gac ctg gcg gtg ctg cag gac aag ctg acc aag aag 1489 Lys Asp Leu Ala Val Leu Gln Asp Lys Leu Arg Ile Ser Thr Lys Lys 485 490 495 ctg gag gag tat gag acc ctg ttc aag tgc cag gag gag acg acg cag 1537 Leu Glu Glu Tyr Glu Thr Leu Phe Lys Cy Gln Glu Glu Thr Thr Gln 500 505 510 aag ctg gtg ctg gag tac cag gca cgg ctg gag gag ggc gag gag cgg 1585 Lys Leu Val Leu Glu Tyr Gln Ala Arg Leu Glu Glu Gly Glu Glu Glu Arg 515 520 ctg cgg cgg gag gac aag gac atc cag atg aag ggc atc atc 1633 Leu Arg Arg Gln Gln Glu Asp Lys Asp Ile Gln Met Lys Gly Ile Ile 530 535 540 agc agg ttg atg tcc gtg gag gaa gaa ctg aag gag gac gac gag Serg Arg Leu Met Ser Val Glu Glu Glu Leu Lys Lys Asp His Ala Glu 545 550 555 560 atg caa gcg gct gtg gac tcc aaa cag aag atc att gat gcc cag gag 1729 Met Gln Ala Ala Val Asp Ser Lys Gln Lys Ile Ile Asp Ala Gln Glu 565 570 575 aag cgc att gcc tcg ttg gat gcc gcc aat gcc cgc ctc atg agt gcc 1777 Lys Arg Ile Ala Ser Leu Asp Ala Ala Asn Ala Arg Leu Met Ser Ala 580 585 590 590 ctg acc cag gtg aaag tagaaacaaa agcccgcttg 1824 Leu Thr Gln Leu Lys Glu Ser Met His 595 600 ctcgcttgct ggaacacagg ggccttttaa gttgagcgtg cgcactgcat gggaaatagc 1884 ggccctggag gatgttagac ttgctccctc tccaagacag cagcagcctg cacctgcccc 1944 gtgtgtgtgg ccggcctcct cctcaccctt cccggccccc ggccaaggac ccaggcgctg 2004 catacagggg aggggcgcac cccacagctg gggccggttt tcctcagctc taggctgttc 2064 tgtagcttat ctgcccctcc cccactttca agacagatga gcaggagctt gggtctctct 2124 cggcccctgt ctgttcccag cccctgcaga ttctgagcaa aggccctggg taagaagggt 2184 gggagtgggg cctttgccag cagagccagg gcagggcgag ctgcaggaat cacccctctg 2244 cccctgcagc tggaatgtgc cacaga ggcc ccacctgaag ggtggatgtg ctggaggggt 2304 ggcccagagc catactgcgt ccaccctgag ctcggggaca ggtgacagtg gctgctctgg 2364 gaaggggctt ttagatgtaa cctacaattc agttaggcta gagacagatg ctggtggagg 2424 aagggctggg ccaccaggga tcacagacca caggaagatg ggaggtggaa gcagaggccc 2484 tgcccccacc ccttcctgtc tcactcttct gtcttgtccc cacccatgcg ccttcgtgcc 2544 tgagaccagg gtggccacac aggcagggcc tggctccagt ctcatcctcc cattgcccag 2604 tgagccctgc tcttctctcc ccagccccct cccaccgctg cctcgtagag tgacctcgga 2664 cagagccccc ctagcaatac agggaggctc ccggggcctg gacaggcggg ctcggaggct 2724 acccgctgtg gccggtgcca gctgcccttg cagggtgggt gagctctcag gccgagagcc 2784 ttatttacct agtgcaaaaa ctgtaaaagt gtacagactc ttcacagatt tttatcttaa 2844 ttgcaagtct gccgattttg taaatgttct tggtgtttga ctgtaatgta actatctcac 2904 ctaatggttg tacatatcct ttggtcctgg tgctgccgag ggctggccgg gactgctgct 2964 ctcccaaggg ttttatttta tttctgaatc tagagaacag tattgggcag gaggaaaagg 3024 cttggtgtct gcggggggtg tcttccctgc ctgtggcatt tgtgtgttgg ctttgcagct 3084 gctgtctgag tagtggccac tggggtgcct t cactgggcc agtcaacggg gggctcctgc 3144 ccaggccaca gagaacctga gttcccggga gctgggccct gcctgcagcc agggctgggg 3204 ttgccagagg ccctggaggg aaggacagtc cctgctgggg aagaacagcc ccggggcccc 3264 ctggtcaccg agactcagcc tctgctggag aaagccacgc cctccctgct agcacagagg 3324 cctgactgac ttttttgctt aacttccatg ttctgggtga tggaaactgc caaacctcct 3384 gtcagtgagg actctttccg actgcccaga aagtgggggt ggaggaccga ggctacagct 3444 ccacacgccc cggtccccca gagcatctgc cccaggtaca cctccccctg cgccccgcac 3504 gactgcggga gccagactgt ccagggaaac agcctctctc ttttctacac actcagccac 3564 aaagcccccc agctcccaca ccgcgtccca gctcccctct tttgtaagta tgtgaaaagg 3624 aaaaaatgca aacgttggag tttgggctgg agctcctccc tccagctgcg acttttaact 3684 atgtaataat gtacagagga agctgttggt gttctaagac tctgtgtggc tgtgcaattt 3744 ctgtacattt gcaattagaa atattaaaga tttatttagc tatttt 3790 <210> 224 <211> 4571 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2567) <400> 224 aa aat aac gag agc agc tta ata gag caa gct cca ata cct cag gac 47 Asn Asn Glu Ser Ser Leu Ile Glu Gln Ala Pro Ile Pro Gln Asp 1 5 10 15 gga ctt acc gtg gca cct cac aga gct cag cga gaa gct gta cac att 95 Gly Leu Thr Val Ala Pro His Arg Ala Gln Arg Glu Ala Val His Ile 20 25 30 gag aag ata atg ttg aaa gga gtc cag aga aaa aga gct gac aaa tac 143 Glu Lys Ile Met Leu Lys Gly Val Gln Arg Lys Arg Ala Asp Lys Tyr 35 40 45 tgg gag tac act ttc aaa gta aat tgg tct gat ctt tca gtc aca aca 191 Trp Glu Tyr Thr Phe Lys Val Asn Trp Ser Asp Leu Ser Val Thr Thr 50 55 60 gta aca aaa acc cac caa gaa cta cag gaa ttt cta ctg aag ctt cca 239 Val Thr Lys Thr His Gln Glu Leu Gln Glu Phe Leu Leu Lys Leu Pro 65 70 75 aag gaa ctg tct tca gag act ttt gac aag acc atc tta aga gcc ctg 287 Lys Glu Leu Ser Ser Glu Thr Phe Asp Lys Thr Ile Leu Arg Ala Leu 80 85 90 95 aat cag ggt tcc ttg aaa agg gag gaa cgg cga cat cct gac cta gag 335 Asn Gln Gly Ser Leu Lys Arg Glu Glu Arg Arg His Pro Asp Leu Glu 100 105 110 cc c atc cta agg cag cta ttt tca agt tca tca caa gct ttt cta caa 383 Pro Ile Leu Arg Gln Leu Phe Ser Ser Ser Ser Gln Ala Phe Leu Gln 115 120 125 agt cag aaa gta cac agc ttc ttt cag tcc ata tca tca gac tcc cta 431 Ser Gln Lys Val His Ser Phe Phe Gln Ser Ile Ser Ser Asp Ser Leu 130 135 140 cac agt atc aat aac tta caa tcc tct ctg aag act tct aag ata tta 479 His Ser Ile Asn Asn Leu Gln Ser Ser Leu Lys Thr Ser Lys Ile Leu 145 150 155 gaa cac tta aaa gaa gac agc tct gaa gct tca agt caa gaa gaa gat 527 Glu His Leu Lys Glu Asp Ser Ser Glu Ala Ser Ser Gln Glu Glu Asp 160 165 170 175 gtg ttg cag cat gcc ata atc cac aag aag cat act ggg aaa agt ccc 575 Val Leu Gln His Ala Ile Ile His Lys Lys His Thr Gly Lys Ser Pro 180 185 190 att gtg aac aat att ggt aca agt tgt tct cca ttg gat ggg ctt acc 623 Ile Val Asn Asn Ile Gly Thr Ser Cys Ser Pro Leu Asp Gly Leu Thr 195 200 205 atg caa tat tct gaa cag aat gga att gtg gat tgg agg aag caa agc 671 Met Gln Tyr Ser Glu Gln Asn Gly Ile Val Asp Trp Arg Lys Gln Ser twenty one 0 215 220 tgt acc acc att caa cac cca gag cac tgt gtg acc tcg gct gac cag 719 Cys Thr Thr Ile Gln His Pro Glu His Cys Val Thr Ser Ala Asp Gln 225 230 235 cat tct gct gaa aaa cgg agt tta tct tca ata aat aag aag aaa gga 767 His Ser Ala Glu Lys Arg Ser Leu Ser Ser Ile Asn Lys Lys Lys Gly 240 245 250 255 aag cca caa aca gaa aag gag aaa att aag aaa act gac aac aga ttg 815 Lys Pro Gln Thr Glu Lys Glu Lys Ile Lys Lys Lys Thr Asp Asn Arg Leu 260 265 270 aat agt aga ata aat ggt att aga ctc tcc act cct cag cat gcc cat 863 Asn Ser Arg Ile Asn Gly Ile Arg Leu Ser Thr Pro Gln His Ala His 275 280 285 ggt ggt act gtg aaa gat gtg aat ttg gac att ggc tct gga cat gac 911 Gly Gly Thr Val Lys Asp Val Asn Leu Asp Ile Gly Ser Gly His Asp 290 295 300 aca tgt gga gaa aca tct tcg gag agt tac agt tct cca tct agt ccc 959 Thr Cys Gly Glu Thr Ser Ser Glu Ser Tyr Ser Ser Pro Ser Ser Pro 305 310 315 cga cat gat gga aga gaa agt ttt gaa agt gaa gaa gag aaa gac aga 1007 Arg His Asp Gly Arg Glu Ser Phe Glu Ser Glu Glu GluLys Asp Arg 320 325 330 335 gac aca gac agc aat tct gag gat tct ggg aat cca tca aca act agg 1055 Asp Thr Asp Ser Asn Ser Glu Asp Ser Gly Asn Pro Ser Thr Thr Arg 340 345 350 ttt aca ggt tac ggt tct gtc aac cag act gtc act gtc aag cca cct 1103 Phe Thr Gly Tyr Gly Ser Val Asn Gln Thr Val Thr Val Lys Pro Pro 355 360 365 gtt caa att gct tca cta gga aat gag aat gga aac ctt tta gaa gat 1151 Val Gln Ile Ala Ser Leu Gly Asn Glu Asn Gly Asn Leu Leu Glu Asp 370 375 380 ccc tta aac tca ccc aag tat cag cat att tct ttt atg cca acg tta 1199 Pro Leu Asn Ser Pro Lys Tyr Gln His Ile Ser Phe Met Pro Thr Leu 385 390 395 cac tgt gtc atg cac aat ggt gcc cag aag tct gaa gtt gtc gtt cct 1247 His Cys Val Met His Asn Gly Ala Gln Lys Ser Glu Val Val Val Pro 400 405 410 415 gca ccc aaa ccc gct gat ggc aaa acc ata ggg atg ctt gtt cct agt 1295 Ala Pro Lys Pro Ala Asp Gly Lys Thr Ile Gly Met Leu Val Pro Ser 420 425 430 cct gtt gct att tct gca ata agg gag tct gca aat tca acc cct gtt 1343 Pro Val Ala Ile Ser Ala Ile A rg Glu Ser Ala Asn Ser Thr Pro Val 435 440 445 gga ata cta ggg cca aca gct tgc act gga gaa tcg gaa aag cac ctt 1391 Gly Ile Leu Gly Pro Thr Ala Cys Thr Gly Glu Ser Glu Lys His Leu 450 455 460 gag tta ctg gct tcc cct tta cct att cca tca acc ttc ctt cca cac 1439 Glu Leu Leu Ala Ser Pro Leu Pro Ile Pro Ser Thr Phe Leu Pro His 465 470 475 agt agt act cct gct ttg cat ctt aca gtt cag agg cta aag ttg cca 1487 Ser Ser Thr Pro Ala Leu His Leu Thr Val Gln Arg Leu Lys Leu Pro 480 485 490 495 cca cca cag gga tct tct gag agc tgc aca gtt aac atc cca caa caa 1535 Pro Pro Gln Gly Ser Ser Glu Ser Cys Thr Val Asn Ile Pro Gln Gln 500 505 510 cca ccc gga agc ctg agc atc gca tca cca aac act gcc ttt att cct 1583 Pro Pro Gly Ser Leu Ser Ile Ala Ser Pro Asn Thr Ala Phe Ile Pro 515 520 525 atc cat aac cca ggt agt ttc cca ggc tct cct gtt gct acc acg gac 1631 Ile His Asn Pro Gly Ser Phe Pro Gly Ser Pro Val Ala Thr Thr Asp 530 535 540 ccc atc aca aaa tct gca tcc caa gtg gta gga ctc aat caa atg gtg 1679 Pro Ile T hr Lys Ser Ala Ser Gln Val Val Gly Leu Asn Gln Met Val 545 550 555 cct caa att gag gga aac aca ggg aca gtc cct cag cct acc aat gtg 1727 Pro Gln Ile Glu Gly Asn Thr Gly Thr Val Pro Gln Pro Thr Asn Val 560 565 570 575 aag gta gtt ctt cca gca gct ggc ctc tca gct gct cag cca cca gct 1775 Lys Val Val Leu Pro Ala Ala Gly Leu Ser Ala Ala Gln Pro Pro Ala 580 585 590 tcc tac ccc tta cca ggc tct ccc ctt gct gcc ggc gtg tta ccc agc 1823 Ser Tyr Pro Leu Pro Gly Ser Pro Leu Ala Ala Gly Val Leu Pro Ser 595 600 605 cag aac tcc agt gtg ctc agc aca gca gca act tct ccc cag cca gcg 1871 Gln Asn Ser Ser Val Leu Ser Thr Ala Ala Thr Ser Pro Gln Pro Ala 610 615 620 agc gca ggt atc agc cag gcc cag gca act gtt cct cct gca gtt cct 1919 Ser Ala Gly Ile Ser Gln Ala Gln Ala Thr Val Pro Pro Ala Val Pro 625 630 630 635 acc acc acc cca ggc cct gcc ccg agc cca agc cct gcc ttg aca cac 1967 Thr His Thr Pro Gly Pro Ala Pro Ser Pro Ser Pro Ala Leu Thr His 640 645 650 655 agt acc gcg cag agt gac agc acc tct tac atc agt gct gtg ggg aac 2015 Ser Thr Ala Gln Ser Asp Ser Thr Ser Tyr Ile Ser Ala Val Gly Asn 660 665 670 acg aac gct aat ggg aca gta gtg cca ccg cag cag atg ggc tca ggt 2063 Thr Asn Ala Asn Gly Thr Val Val Pro Pro Gln Gln Met Gly Ser Gly 675 680 685 cct tgt ggt tct tgt ggg cga agg tgc agc tgt ggg acc aat gga aac 2111 Pro Cys Gly Ser Cys Gly Arg Arg Cys Ser Cys Gly Thr Asn Gly Asn 690 695 700 ctt cag cta aat agt tac tat tat cct aat cca atg cct gga cca atg 2159 Leu Gln Leu Asn Ser Tyr Tyr Tyr Pro Asn Pro Met Pro Gly Pro Met 705 710 715 tac cga gtc cct tca ttc ttt act ctg cca tcc att tgc aat ggc agc 2207 Tyr Arg Pro Ser Phe Phe Thr Leu Pro Ser Ile Cys Asn Gly Ser 720 725 730 735 tac ctc aac caa gca cat cag agc aat gga aac caa ctt cct ttt ttt 2255 Tyr Leu Asn Gln Ala His Gln Ser Asn Gly Asn Gln Leu Pro Phe Phe 740 745 750 ctg cct cag act cca tat gca aat gga ctg gta cat gac cca gtc atg 2303 Leu Pro Gln Thr Pro Tyr Ala Asn Gly Leu Val His Asp Pro Val Met 755 760 765 ggg agc caa gcc aac tat ggc atg cag cag atg gca gga ttt ggg aga 2351 Gly Ser Gln Ala Asn Tyr Gly Met Gln Gln Met Ala Gly Phe Gly Arg 770 775 780 ttc tat cct gta tat cca gca cct aac gta gtt gcc aac acc agt ggt 2399 Phe Tyr Pro Val Tyr Pro Ala Pro Asn Val Val Ala Asn Thr Ser Gly 785 790 795 tcg ggg ccc aag aag aat ggg aat gtc tca tgt tac aat tgt ggt gta 2447 Ser Gly Pro Lys Lys Asn Gly Asn Val Ser Cys Tyr Asn Cys Gly Val 800 805 810 810 815 815 agc gga cac tat gca cag gac tgt aag cag tcg tcc atg gag gcc aat 2495 Ser Gly His Tyr Ala Gln Asp Cys Lys Gln Ser Ser Met Glu Ala Asn 820 825 830 caa caa ggc act tac aga ctg aga tac gca ccc ccc ct cct tct 2543 Gln Gln Gly Thr Tyr Arg Leu Arg Tyr Ala Pro Pro Leu Pro Pro Ser 835 840 845 aat gat acg ttg gat tct gca gac tgaaacgagt aaagcttgcc tacttaatac 2597 Asn Asp Thr Leu Asp Ser Ala Asp 850 gg gatcagt gg gt gagatt 2657 tgtctataca tttcctagat ttctatgcag ttgggatttt tcatttctct tgtaccaatg 2717 tccaaaacaa gaaagaatgc aatgcttttg agcctctggt ctcctggtt c aacaacaggc 2777 ttatatgtat gatacatgta atttaaacct tcagacaaac ttaaatgttg gtgcgtgctt 2837 tttttttttt tttacactga atacttgctg tgtgcaatgt ttactgaatc tttaaaactg 2897 tgtatttgac ctttttttta caacactggt gacagtcata tggttttgaa aaaaaaaaga 2957 aattttgctt cttcccagct tttctcactt tcaccctaaa cgacacttcc tccccagcca 3017 gcctcactct gtctccggcc cgcagcagga gcagccagca gtgcattcac cccacttttg 3077 taaactgctc tgcatataaa ccaagggcag aatgtttcac cctgatctta tgggaggaat 3137 caaactccca aaatagtgtg tatatatgta ataaacagcg tcacgtaaat acatatatgc 3197 agtgcttgtt gtccaaatag aaatgaaaat aagtggaaga gagaggaaga agtcaaacca 3257 tatgaaactg aaaaaatatg acgtacgaaa tggacaaaaa gctttttctg aaaccaactt 3317 tttacttcca tcatcctttt ttagcctgtt gcttcagaga gacacaaagt gaacacactg 3377 gtgtgaatgt cgctctctgt gtgcttgtgt ttgtaatgaa agtctacagc caattttact 3437 tgtctaccac cgtgttgtgc tcaaagagac actacttgag tgaagatttc ttctttccct 3497 gtaccagctg ttacagtgtt acgttgtgtt taaaatgtgt atggtttatt gcaatctgaa 3557 cagagctatg ggtttctacc ataagtcagg ttgtttgttc cctaacctgt ctct cgtagc 3617 aaagtcactt ttataacagt ttaccactat gcttgattat aatgtgaaag gcggaattct 3677 gagtgtgtta agatggtatt aatcatgtcg gtgtcatgtc actaagttta atgctgctgt 3737 ttttaaaaaa aaaaaagttt ttttaaaaag ccaatctatg tactaaattg cttccaggta 3797 atttttgatt tcctaaagtg cactgaggtt atctggaaga ttgggtgtat tttttggtga 3857 ctgctgcatt catcagcaat gaacagtttc cactgtatag tcctaggggt cagggggtgg 3917 gggtttcatt ttccattcct cagcacagag cagaaatgat agatttttat tgtttggagt 3977 aacgttggta tgcagcagag gaacgtaaac atttggtctt ggttcagaag cctaacagat 4037 tgctagacaa gagaaaaaac ttgaagaaaa aagaagctta atttcatgct tcataagtag 4097 catttatatt tatagcacca atgtacattt tgaaactttc tttcaggggt gggagttatg 4157 gggaaggggt gggtgtgaag gggtagatga aagctttaat ttagaaagaa agttcaagta 4217 aaggaaatta ttttgattaa atatatttta tttgatctgg gtatttttgg accacattat 4277 taaattaatt gttaagctgc agttgagttg ttcaagtgag agttttgata agccacttat 4337 gggccgcgtt gtgaatcact tgccagttgt actttatgga gcttatttta tgatttaaaa 4397 tactgtactg tacataggag gtatgttacc ttctccttat ttgtatgttt accatatac t 4457 ttgatatttg aaatgttatg tactggaaag gccacttata tttctagaac agattggatt 4517 ttatgcaacc ttttttcctt gaattaacag caataaaaaa atgaaaaaca gctt 4571 <210> 225 <211> 4105 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1499) .. (3793) <400> 225 ggagagtggg ccttaccaga agaaatggtt gacaatttac caccctccaa caattgcata 60 ctgggccata ttcttcacag gctagctgaa aaatctcttc ctcctcgagc ggaatcaaca 120 acacctgaat taccttcatt tgctgttaaa ggatgcttat tggggaaaac attaagtgga 180 aaaactacca ttttaaggtc tctacaaaaa gactttccta tacagatact ttctattgac 240 actcttgtcc aagaagctat ccaagcattt catgacaatg aaaaagtcag tgaggttcta 300 ccaattcaga aaaatgatga agaagatgct ctaccagttc tgcaagagga gattaaagaa 360 agccaggatc cacaacatgt attttcagct ggtccagttt cagatgaagt attaccagaa 420 acagaaggtg ctaatgctga taaaacacca aaagctgaag aagtcaaatc aagtgatagt 480 ttcttaaaac tcactacacg tgctcagctt ggtgcaaaat cagaacagtt gctgaagaaa 540 ggaaagagca ttcctgatgt gctgcttgtt gacatcatag taaatgctat taacgagata 600 cctgtgaatc aagactgtat cctagatggt tttccaatga ctttaaacca agcacagctt 660 ctggaagaag ctcttacagg ctgcaataga aacctcacag aagtggaaag aaaaaaagca 720 caaaaatcca cattggctat tgatcctgcg acttccaaag aaatacctct tccctctcct 780 gcatttgatt ttgtcatatt attagatgtt tcagatactt cctcaatgag tcgcatgaat 840 gatattatag ctgaagaatt gtcctataaa actgctcacg aagatatcag tcaacgtgta 900 gctgctgaaa accaagataa ggatggagac caaaatttaa gagaccagat acaacataga 960 attataggct tcttggacaa ctggccttta ttggagcaat ggttttcaga gccagaaaat 1020 attttgataa aaatcaatgc tgaaatagat aaggaatctt tatgtgaaaa agtaaaagaa 1080 attcttacga ctgaaatagc aaaaaaaaag aataaagttg agaagaaatt agaagaaaag 1140 gaagctgaga aaaaagcagc agtttccctg gctgagcttc cacttcctac acctcctcct 1200 gctcctcctc ctgaaccaga aaaagagaag gaaattcatc aaagccatgt gccttcaaaa 1260 actcctactg caaaaggaaa acctcaatca gaagccccgc atggtaagca agaatctctt 1320 caggaaggaa aagggaagaa aggtgagacc gcactcaaaa gaaaaggttc tcctaaagga 1380 aaatcatcag gaggaaaagt accagtaaag aaatcacctg ctgactctac agatacatca 1440 cctgttgcaa tagtgccaca gccacctaag ccaggatcag aagaatgggt ctatgtga 1498 atg aac cag ttc ctg aga aca agt ttc cag gag ttt cta aag cgt ccg 1546 Met Asn Gln Phe Leu Arg Thr Ser Phe Gln Glu Phe Leu Lys Arg Pro 1 5 10 15 gat cac aag caa gat ttt gta gct caa tgg cag gct gat ttc aac tcc 1594 Asp His Lys Gln Asp P he Val Ala Gln Trp Gln Ala Asp Phe Asn Ser 20 25 30 ctt cct gat gac ctg tgg gat gat gag gaa aca aag gct gaa cta cat 1642 Leu Pro Asp Asp Leu Trp Asp Asp Glu Glu Glu Thr Lys Ala Glu Leu His 35 40 45 caa cga gtg aat gat ctg cga gac cgc ctg tgg gac att tgt gat gcc 1690 Gln Arg Val Asn Asp Leu Arg Asp Arg Leu Trp Asp Ile Cys Asp Ala 50 55 60 cgg aag gaa gag gcg gag cag gag cgg ctt gat atg gag agc 1738 Arg Lys Glu Glu Ala Glu Gln Glu Arg Leu Asp Ile Ile Asn Glu Ser 65 70 75 80 tgg tta cag gac act ctt gga atg aca atg aac cat ttc ttt tcc ctg 1786 Trp Leu Gln Asp Thr Leu Gly Met Thr Met Asn His Phe Phe Ser Leu 85 90 95 atg cag gca gag ctg aac cgt ttc caa gat aca aag aga ctc ctt caa 1834 Met Gln Ala Glu Leu Asn Arg Phe Gln Asp Thr Lys Arg Leu Leu Gln 100 105 110 gat tat tac tgg gga atg gaa agt aaa atc cca gta gag gac aac aag 1882 Asp Tyr Tyr Trp Gly Met Glu Ser Lys Ile Pro Val Glu Asp Asn Lys 115 120 125 aga ttt act cga atc cct ttg gtc caa ctg gat agt aaa gac aat tct 1930 Arg Phe Thr Arg I le Pro Leu Val Gln Leu Asp Ser Lys Asp Asn Ser 130 135 140 gaa agc cag ctt aga att cct cta gtt cct cga ata tcc att tct ctg 1978 Glu Ser Gln Leu Arg Ile Pro Leu Val Pro Arg Ile Ser Ile Ser Leu 145 150 155 160 gaa aca gtt aca ccc aaa cca aaa aca aaa tca gta ctg aag ggc aag 2026 Glu Thr Val Thr Pro Lys Pro Lys Thr Lys Ser Val Leu Lys Gly Lys 165 170 175 atg gat aac tcc cta gaa aac gtt gag tcc aac ttt gag gcc gat gaa 2074 Met Asp Asn Ser Leu Glu Asn Val Glu Ser Asn Phe Glu Ala Asp Glu 180 185 190 aag ttg gtc atg gac acc tgg cag cag gct tct tta gca gta tct cac 2122 Lys Leu Val Met Asp Thr Trp Gln Gln Ala Ser Leu Ala Val Ser His 195 200 205 atg gtg gct gct gaa att cat cag agg ctt atg gaa gaa gaa aaa gaa 2170 Met Val Ala Ala Glu Ile His Gln Arg Leu Met Glu Glu Glu Lys Glu 210 215 220 aac cag cca gca gac ccc aaa gaa aaa tct cct cag atg ggt gca aat 2218 Asn Gln Pro Ala Asp Pro Lys Glu Lys Ser Pro Gln Met Gly Ala Asn 225 230 235 240 aaa aaa gtc aaa aag gag cca ccc aag aaa aaa cag gaa gac aaa aaa 2266 Lys Lys Val Lys Lys Glu Pro Pro Lys Lys Lys Gln Glu Asp Lys Lys 245 250 255 ccc aaa ggt aaa tca cca cct atg gca gaa gca act cct gtc ata gta 2314 Pro Lys Gly Lys Ser Pro Pro Met Ala Glu Ala Thr Pro Val Ile Val 260 265 270 aca aca gag gaa att gct gaa atc aaa agg aaa aat gaa ctg agg gtc 2362 Thr Thr Glu Glu Ile Ala Glu Ile Lys Arg Lys Asn Glu Leu Arg Val 275 280 285 aaa ata aaa aaa gaa cac gcc ttg caa ttt gaa gaa ata gcc 2410 Lys Ile Lys Glu Glu His Leu Ala Ala Leu Gln Phe Glu Glu Ile Ala 290 295 300 acg caa ttt cga ctt gaa ctg ata aag aca aaa gca ttg gct ctt ctt 2458 Thr Gln Glu Leu Ile Lys Thr Lys Ala Leu Ala Leu Leu 305 310 315 320 gaa gat tta gta aca aag gtg gtt gat gta tat aaa ctc atg gaa aaa 2506 Glu Asp Leu Val Thr Lys Val Val Asp Val Tyr Lys Leu Met Glu Lys 325 330 335 tgg ctt ggt gag agg tat ttg aat gaa atg gcc agt aca gaa aaa tta 2554 Trp Leu Gly Glu Arg Tyr Leu Asn Glu Met Ala Ser Thr Glu Lys Leu 340 345 350 act gac gta gct cgc tat cac att gaa acat aca aaa att cag aat 2602 Thr Asp Val Ala Arg Tyr His Ile Glu Thr Ser Thr Lys Ile Gln Asn 355 360 365 gaa ctt tat tta agc caa gaa gac ttc ttc att aat ggc aat ata aaa 2650 Glu Leu Tyr Leu Ser Gln Glu Asp Phe Phe Ile Asn Gly Asn Ile Lys 370 375 380 gtc ttc cca gat cct ccc cca tca ata cgt cct cca cct gta gaa aag 2698 Val Phe Pro Asp Pro Pro Pro Ser Ile Arg Pro Pro Pro Val Glu Lys 385 390 395 400 400 gaa gaa gat ggt acc ctg acc att gaa cag ctt gac agt ctt cga gat 2746 Glu Glu Asp Gly Thr Leu Thr Ile Glu Gln Leu Asp Ser Leu Arg Asp 405 410 415 cag ttc tta gat atg gca cct aaa ggc ata ata gga aat aaa gcatt 2794 Gln Phe Leu Asp Met Ala Pro Lys Gly Ile Ile Gly Asn Lys Ala Phe 420 425 430 act gac att ctg atc gat ttg gtg acc ctg aac ctt ggc aca aac aac 2842 Thr Asp Ile Leu Ile Asp Leu Val Thr Leu Asn Leu Gly Thr Asn Asn 435 440 445 ttt cct agt aat tgg atg cac ctt acc caa cct gaa tta cag gaa tta 2890 Phe Pro Ser Asn Trp Met His Leu Thr Gln Pro Glu Leu Gln Glu Leu 450 455 460 aca tct tta tta aca gtc aac tcc gag ttc gtg gac tgg cgg aag ttc 2938 Thr Ser Leu Leu Thr Val Asn Ser Glu Phe Val Asp Trp Arg Lys Phe 465 470 475 475 ctg tta gta acc tca atg cct tgg ccc att ccc ttg gag gag gag Lec cu 2986u Val Thr Ser Met Pro Trp Pro Ile Pro Leu Glu Glu Glu Leu 485 490 495 ctt gag acc ctt cag aag ttc aag gct gtg gat aag gag cag ttg ggc 3034 Leu Glu Thr Leu Gln Lys Phe Lys Ala Val Asp Lys Glu Gln Leu Gly 500 505 510 acc atc act ttt gag cag tat atg cag gct ggt ctg tgg ttt aca gga 3082 Thr Ile Thr Phe Glu Gln Tyr Met Gln Ala Gly Leu Trp Phe Thr Gly 515 520 525 gat gaa gat ata aaa att cca gaa aat cct ctt gaa ccc ctt cca ttt 3130 Asp Glu Asp Ile Lys Ile Pro Glu Asn Pro Leu Glu Pro Leu Pro Phe 530 535 540 aat agg cag gag cat ctt ata gag ttt ttc ttt agg cta ttt gct gac 3178 Asn Arg Gln Glu His Leu Ile Glu Phe Phe Phe Arg Leu Phe Ala Asp 545 550 555 560 tat gag aag gat cca ccc cag ctt gac tac aca cag atg ctg ctt tac 3226 Tyr Glu Lys Asp Pro Pro Gln Leu Asp Tyr Thr Gln Met Leu Leu Tyr 565 570 575 ttt gct tgc cac cca gac acc gtg gaa gga gtc tac agg gcc ctc agt 3274 Phe Ala Cys His Pro Asp Thr Val Glu Gly Val Tyr Arg Ala Leu Ser 580 585 590 590 gtg gct gtt gga act cat gtc ttc caa caa gtc aaa g att cca 3322 Val Ala Val Gly Thr His Val Phe Gln Gln Val Lys Ala Ser Ile Pro 595 600 605 agt gca gaa aag acc tcc tca act gat gca ggt cca gct gag gaa ttt 3370 Ser Ala Glu Lys Thr Ser Ser Thr Thr Asp Ala Gly Pro Ala Glu Glu Phe 610 615 620 cct gaa cct gag gaa aat gct gca aga gaa gaa agg aaa tta aaa gac 3418 Pro Glu Pro Glu Glu Asn Ala Ala Arg Glu Glu Arg Lys Leu Lys Asp 625 630 635 640 gac agg gag gaa cag aag gat gaa gaa atc cct gaa aat gca 3466 Asp Thr Glu Lys Arg Glu Gln Lys Asp Glu Glu Ile Pro Glu Asn Ala 645 650 655 aac aat gaa aag atg tcc atg gaa aca cta ctc aaa gtg ttc aaa gtg ttc Glu Lys Met Ser Met Glu Thr Leu Leu Lys Val Phe Lys Gly 660 665 670 gga agt gaa gca cag gac tcc aat aga ttt gcc agc cac cta aag ata 3562 Gly Ser Glu Ala Gln Asp Ser Asn Arg Phe Ala Ser His Leu L ys Ile 675 680 685 gag aac att tat gca gag ggc ttc ata aaa aca ttt caa gac cta ggt 3610 Glu Asn Ile Tyr Ala Glu Gly Phe Ile Lys Thr Phe Gln Asp Leu Gly 690 695 700 gcc aag aac ctg gag cca att gct gtt ctc ttg aag cat cct 3658 Ala Lys Asn Leu Glu Pro Ile Glu Val Ala Val Leu Leu Lys His Pro 705 710 710 715 720 ttt att caa gac ctg att tca aat tat tca gac tat aag ttt cct gta 3706 Phe Ile Gln Asp Leu Ile Ser Asn Tyr Ser Asp Tyr Lys Phe Pro Val 725 730 735 cac atc atc tat gta gtg gaa atg ata gtg tgt gca aaa ggt tgg gca 3754 His Ile Ile Tyr Val Val Glu Met Ile Val Cys Ala Lys Gly Trp Ala 740 745 750 750 cca ctt cca tca gga aaa cag tgt gca aga tgg aga aac taaggacaaa 3803 Pro Leu Pro Ser Gly Lys Gln Cys Ala Arg Trp Arg Asn 755 760 765 ccccagagaa actggacaaa cccagcagaa gaaaggaaga actgcaactc agaaatcaca 3863 taaccaccaa gcaggtctgg accacacatg ctaaatgtgc atccactatg gcgagtccca 3923 ggcctttaac agcagggact aaggagggca gaggctgaca ccaaccccct ttcatactgt 3983 agcactacat ccctctcaga taccagttta acacgaagtc tccctgt ttg actcctgtga 4043 gttgtgtatt gaactacaaa gtgtttgctg agttgaaaat aaaagcgctt tcactttgat 4103 ag 4105 <210> 226 <211> 4328 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (66) .. (1382) <400> 226 aagattatag agacttgctt tagaaccaca agaagaaaga ggaggccggc ttttcagcta 60 gcatc atg gcg tgg ccg tgc atc acg agg gcc tgc tgc atc gcc cgc ttc 110 Met Ala Trp Pro Cys Ile Thr Arg Ala Cyg Ile Thr Arg Ala Cyla ttg gac aaa gcg gac atc gct gtg ccg ctg gtt ttc acc 158 Trp Asn Gln Leu Asp Lys Ala Asp Ile Ala Val Pro Leu Val Phe Thr 20 25 30 aag tac tcg gag gcc acc gag cac ccg ggc gcc ccg ccg cag cac cac Lys Tyr Ser Glu Ala Thr Glu His Pro Gly Ala Pro Pro Gln Pro Pro 35 40 45 ccg ccg cag cag cag gcg cag ccg gcg ctc gcg ccc ccc tcg gcg cgc 254 Pro Pro Gln Gln Gln Ala Gln Pro Ala Leu Ala Pro Pro Ser Ala Arg 50 55 60 gcg gtt gcc ata gag acg cag cca gcc cag ggc gag ttg gat gca gtt 302 Ala Val Ala Ile Glu Thr Gln Pro Ala Gln Gly Glu Leu Asp Ala Val 65 70 75 gcc cgg gca acg ggg cca gcg cct ggg cct acc ggc gag cgc gag ccg 350 Ala Arg Ala Thr Gly Pro Ala Pro Gly Pro Thr Gly Glu Arg Glu Pro 80 85 90 95 gcg gcg ggc ccc ggc cgg agc ggg ccg ggc ccg ggc ctg ggc tcc ggc 398 Ala Ala Gly Pro Gly Arg Ser Gly Pro Gly Pro Gly Leu Gly Ser Gly 100 105 110 tcc acc tcc ggc ccc gcg gac tcg gtg atg cgg cag gat tac cga gcc 446 Ser Thr Ser Gly Pro Ala Asp Ser Val Met Arg Gln Asp Tyr Arg Ala 115 120 125 tgg aag gtg cag cgg ccc gag ccc agc tgc cgg ccg cgc agc gaa tac 494 Trp Lys Val Gln Arg Pro Glu Pro Ser Cys Arg Pro Arg Ser Glu Tyr 130 135 140 cag ccc tcc gac gct ccc ttc gag cgc gag acc cag tac cag aag gac 542 Gln Pro Ser Asp Ala Pro Phe Glu Arg Glu Thr Gln Tyr Gln Lys Asp 145 150 155 ttc cgc gcc tgg ccg ctg ccg cgc cgc ggg gac cac ccg tgg atc ccc 590 Phe Leg Ala Trp Pro Arg Arg Gly Asp His Pro Trp Ile Pro 160 165 170 175 aag ccc gtg cag atc tct gcg gcc tcc cag gcg tcg gcg ccc att ctc 638 Lys Pro Val Gln Ile Ser Ala Ala Ser Gln Ala Ser Ala Pro Ile Leu 180 185 190 ggg gcg ccc aag cgc cgg ccg cag agc cag gag cgc tgg cca gtg cag 686 Gly Ala Pro Lys Arg Arg Pro Gln Ser Gln Glu Arg Trp Pro Val Gln 195 200 205 gcc gcc gct gag gcc cgg gag cag gag gcg gcc ccc ggggt 734 Ala Ala Ala Glu Ala Arg Glu Gln Glu Ala Ala Pro Gly Gly Ala Gly 210 215 220 ggc ctg gcg gcc gga aag gcg tcc ggg gcg gac gag cgc gac acg cgc 782 Gly Leu Ala Ala Gly Lys Ala Ser Gly Arg Asp Thr Arg 225 230 235 agg aag gcc ggg cct gcc tgg atg gtg cgc cgc gcc gag ggc ctg ggg 830 Arg Lys Ala Gly Pro Ala Trp Met Val Arg Arg Ala Glu Gly Leu Gly 240 245 250 255 cac gag cag acg ccg ccc gcg gcc cag gcc cag gtc cag gcc acc 878 His Glu Gln Thr Pro Leu Pro Ala Ala Gln Ala Gln Val Gln Ala Thr 260 265 270 ggc ccc gag gct ggc agg ggg cgc gcc gcg gcg gac gcc ctc aac cgg Gly Pro Gly Ala Gly Arg Gly Arg Ala Ala Ala Asp Ala Leu Asn Arg 275 280 285 caa atc cgc gag gag gtg gcg agt gca gtg agc agc tcc tac agg aat 974 Gln Ile Arg Glu Glu Val Ala Ser Ala Val Ser Ser Tyr Arn Asn 295 300 gaa ttc agg gca tgg acg gac atc aag cct gtg aaa cca ata aag gcc 1022 Glu Phe Arg Ala Trp Thr Asp Ile Lys Pro Val Lys Pro Ile Lys Ala 305 310 315 aag ccc cag tac aag ccc cca gat gat aag atg gt t cat gag acc agc 1070 Lys Pro Gln Tyr Lys Pro Pro Asp Asp Lys Met Val His Glu Thr Ser 320 325 330 335 tac agt gct cag ttc aaa gga gag gcc agc aag cca aca aca gct gac 1118 Tyr Ser Ala Gln Phe Lys Gly Glu Ala Ser Lys Pro Thr Thr Ala Asp 340 345 350 aat aag gtc att gat cgc aga aga ata cgc agc ctc tac agc gaa ccc 1166 Asn Lys Val Ile Asp Arg Arg Arg Ile Arg Ser Leu Tyr Ser Glu Pro 355 360 365 ttc aag gaa ccc cca aag gtg gaa aaa cct agt gtt cag agt tcc aaa 1214 Phe Lys Glu Pro Pro Lys Val Glu Lys Pro Ser Val Gln Ser Ser Lys 370 375 380 cca aaa aag acc tca gcg agc cat aag ccc acg agg aag gcc aaa gac 1262 Pro Lys Lys Thr Ser Ala Ser His Lys Pro Thr Arg Lys Ala Lys Asp 385 390 395 aag cag gcg gtg tca ggc cag gct gcc aag aaa aag ag agc gcg gag ggc 1310 Lys Gln Ala Val Ser Gly Gln Ala Ala Lys Lys Lys Ser Ala Glu Gly 400 405 410 415 ccg agt acc acc aag cca gac gac aag gag caa agc aaa gag atg aac 1358 Pro Ser Thr Thr Lys Pro Asp Asp Lys Glu Gln Ser Lys Glu Met Asn 420 425 430 430 aat aaa ctg gct gag gcg aaa gag taaatttccc tgcactttcc ttttactctt 1412 Asn Lys Leu Ala Glu Ala Lys Glu 435 ctctctctct ccctcccccc aacttttttt ttttaaacca acaaaccaaa aaaggccaca 1472 aaattaatta gaggcttctc atctgccttg gtcctgagtg ttccaggagc tctttggttt 1532 ggcttctttt gatggaagaa tcctgcttca cagactgagt ggcaggcctc ctcctgaggg 1592 cagcccctgg agcaccagga agcgttgccg ctggctgtgc cctcccctgg cactctgact 1652 gcatgctgat gagcaaggca ggcaggtctg agaggcgaaa cgaatctccc ggcagtgctt 1712 ggaagtgtct gtggggtctc ctcctcccag atccccaaga tctgtgtcac tggtcgattt 1772 tgaactttag gtacatgtgt tcttttcaaa aattcagaga atcgtcatgt gccacagaag 1832 ctcagcctgg gcttcagcaa ttgacaaaat ttgaagaaat attaaacaaa aataacaaaa 1892 aaagaaacaa ccttggcctt aatgtcaata aaagggagtt gtgtctgtta agtggtcttt 1952 tcatagaatc gtccattaga aatgtgtgcc tgtgtttagc ttcctatcag tgggctttaa 2012 attgtatacc gagtcataga tacgccactg ataactaaaa ctagatcagg gctggtgaag 2072 aaggttaggt gttttaggta cattccagct gtcataggaa gatcacagaa atgaggaggc 2132 tgttttcctc tgattctcct cggccgacca cctgtccaat gctgctggtt tcgcagagc g 2192 accggttgga gatgtctgag gaagaaagtt caaggtgtag ggatagtgtg tttggaattt 2252 gactttccat ttctgagacc caagggggcg tagatgtagt ggcaagtgtg gcgatgttta 2312 ctctcccttc ctgaaccgct ctggtctgct cctcagagag ggcagcggtg ccaggcctca 2372 ggtcagggag aatgtctgtg acttagctgc agactaggag actgccctgc taactaatta 2432 gcaagcagct ttgacctcat taatatataa aagcagctct cagtatattc cgtgtcgtgt 2492 gtgtgtgtgg ccaaagcccc caagggtggc aagtgccacc ttcgctgtgc tagagttgtg 2552 ttgtaggaat tagtcaggga gttgttgtga aaaaaaaaac cccagtgctt gtgagggaac 2612 tcaaaatagt taccagaaaa ataatatttg ccaatatgac gtgtatattg ctcagcacac 2672 tctgtatctc ctgtccttaa aatcctcttg tccccggcat tctgacacac tgggctgccg 2732 tccggtgtca agccccggcg caggcttgct cttcttttac aatgaaaggg gtgaagagtg 2792 agggtctcac agttccttac ctcaaagtcc ctttaggtcc ttctggtttg gaggaagtgg 2852 agcctccacg aactctctct tactccgacc attcaggcag caaagtctct gcttacatca 2912 ttttggttgt caccttgggg ctgagtgaga agtcttttgt aaattaattc ggcgtgtgct 2972 acatgagcca taattattaa cagaacagga atatcagaaa cgaagttgtt gatcaggccc 303 2 actgcgacct tcctttctat ctcagggttt aaaactgtga ggaaggagaa gtatgaagga 3092 aggtagaaaa tgctggtggg tctccgtgtt tatgagtcac agattttgaa agctatcagg 3152 aaatgactag agtggatcct ggcactgatt ccaactcttt gccagctaat cttaacattt 3212 agcagaaagc tctagcaaca tgatcttaat tgtatccaga ggatttgcca atgtatgttc 3272 agtctctcaa gatttggcat tagtcagaca tgttgatgct agccacaatt tggatttctc 3332 catagaataa tcatttattt ttgcagatca aataaatcag agtttacaat gcacagggga 3392 tcatttattt agcattccct tgctagaagc ccgtgtgcca ggcactgtgc tagaagtggt 3452 gggcagtata aagaaatctg tctccacagc cacacaacca gagggtgcac atgacttgat 3512 ccctatgacc aagtcaagtt ggtgttgccc aaatcgcagt ttgacataag ggtcccacag 3572 gcttccccac cccccgcccc cactcactgc cccagggacc aacttcctac cctcacccaa 3632 ggctttagag gacctgtagc atgtcttttt caacctgtca gtatcccctt ctgcttaaca 3692 cacccactga gaaaaccctg tttgtagttc actttgactc ttgaatgtgt cactttactg 3752 gcaagagact tcctttgatt tctactgttt acaaataaaa ctcagccagt ctcattctat 3812 atcccaaacg tactgaatga aactgatttt ggttccacaa gcagtgtttg ggtgttgcct 3872 tcct gaaggt gaccaagctt ccaaagctcg tcccactggc ctctgtacat ttccctgtgg 3932 ttctccgtcc ttccctggcg agggagctgg gactgaagct ttcccgctgt ttccctgcct 3992 gcaaaagcag ccccaagagc tgcgcattgg cttccctcag caatctgtcc tgtctgtgct 4052 cccattcggt ccacatagct ttctttgcct ctctgaggca gacaggaagt gtctaattac 4112 gattttgtgg cctgggtttt gttgcatacc acagattgtc tatgtaacat gtagcgcaca 4172 cctctcttgg tgctatttca ttcctgctgt aagagaatga caaaaatatt catgtatagc 4232 caattgattg tgacgtgctt gtggtctgtg cttgctcaga aaaacaaaca aacaaacagt 4292 ttttccaatt ataaataaat gctaaagacg aacacc 4328 <210> 227 <211> 3766 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (70) .. (2748) <400> 227 gctctgccca agccgaggct gcggggccgg cgccggcggg aggactgcgg tgccccgcgg 60 aggggctga gtt tgc cag ggc cca ctt gac cct gtt tcc cac ctc ccg ccc 111 Val Cys Gln Gly Pro Leu Asp Prog Ser Leg Asc Pro gag ggc ccc cgg ggc gac tcg ggg gcg gac cgc 159 Pro Arg Ser Gly Gly Gly Gly Pro Arg Gly Asp Ser Gly Ala Asp Arg 15 20 25 30 ggg gcg gag ctg ccg ccc gtg agt ccg gcc gag cca cct gag ccc gag 207 Glu Leu Pro Pro Val Ser Pro Ala Glu Pro Pro Glu Pro Glu 35 40 45 ccg cgg gac acc gtc gct cct gct ctc cga atg ctg cgc acc gcg atg 255 Pro Arg Asp Thr Val Ala Pro Ala Leu Arg Met Leu Arg Thr Ala Met 50 55 60 ggc ctg agg agc tgg ctc gcc gcc cca tgg ggc gcg ctg ccg cct cgg 303 Gly Leu Arg Ser Trp Leu Ala Ala Pro Trp Gly Ala Leu Pro Pro Arg 65 70 75 cca ccg ctg ctg ctg ctg ctg ctg ctg ctg cag ccg ccg 351 Pro Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Pro 80 85 90 cct ccg acc tgg gcg ctc agc ccc cgg atc agc ctg cct ctg ggc tct 399 Pro Pro Thr Trp Ala Leu Ser Pro Arg Ile Ser Leu Pro Leu Gly Ser 95 100 105 110 gaa gag cgg cca ttc ctc aga ttc gaa gct gaa cac atc tcc aac tac 447 Glu Glu Arg Pro Phe Leu Arg Phe Glu Ala Glu His Ile Ser Asn Tyr 115 120 125 aca gcc ctt ctg ctg agc agg gat ggc agg acc ctg tac gtg ggt gct 495 Thr Ala Leu Leu Leu Ser Arg Asp Gly Arg Thr Leu Tyr Val Gly Ala 130 135 140 cga gag gcc ctc ttt gca ctc agt agc aac ct agc ttc ctg cca ggc 543 Arg Glu Ala Leu Phe Ala Leu Ser Ser Asn Leu Ser Phe Leu Pro Gly 145 150 155 ggg gag tac cag gag ctg ctt tgg ggt gca gac gca gag aag aaa cag 591 Gly Glu Tyr Gln Glu Leu Leu Gly Ala Asp Ala Glu Lys Lys Gln 160 165 170 cag tgc agc ttc aag ggc aag gac cca cag cgc gac tgt caa aac tac 639 Gln Cys Ser Phe Lys Gly Lys Asp Pro Gln Arg Asp Cys Gln Asn Tyr 175 180 ag 190 atc atc ctc ctg ccg ctc agc ggc agt cac ctg ttc acc tgt ggc 687 Ile Lys Ile Leu Leu Pro Leu Ser Gly Ser His Leu Phe Thr Cys Gly 195 200 205 aca gca gcc ttc agc ccc atg tgt acc tac atc aac atgag735 Thr Ala Ala Phe Ser Pro Met Cys Thr Tyr Ile Asn Met Glu Asn Phe 210 215 220 acc ctg gca agg gac gag aag ggg aat gtc ctc ctg gaa gat ggc aag 783 Thr Leu Ala Arg Asp Glu Lys Gly Asn Val Leu Leu Glu Asp Gly Lys 225 230 235 ggc cgt tgt ccc ttc gac ccg aat ttc aag tcc act gcc ctg gtg gtt 831 Gly Arg Cys Pro Phe Asp Pro Asn Phe Lys Ser Thr Ala Leu Val Val 240 245 250 gat ggc gag ctc tac act ggaca gtc agc agc ttc caa ggg aat gac 879 Asp Gly Glu Leu Tyr Thr Gly Thr Val Ser Ser Phe Gln Gly Asn Asp 255 260 265 270 ccg gcc atc tcg cgg agc caa agc ctt cgc ccc acc aag acc gag agc 927 Pro Ala Ile Arg Ser Gln Ser Leu Arg Pro Thr Lys Thr Glu Ser 275 280 285 tcc ctc aac tgg ctg caa gac cca gct ttt gtg gcc tca gcc tac att 975 Ser Leu Asn Trp Leu Gln Asp Pro Ala Phe Val Ala Ser Ala Tyr Ile 290 295 300 cct gag agc ctg ggc agc ttg caa ggc gat gat gac aag atc tac ttt 1023 Pro Glu Ser Leu Gly Ser Leu Gln Gly Asp Asp Asp Lys Ile Tyr Phe 305 310 315 ttc ttc agc gag act ggc gag tga t gtt g aac acc att 1071 Phe Phe Ser Glu Thr Gly Gln Glu Phe Glu Phe Phe Glu Asn Thr Ile 320 325 330 gtg tcc cgc att gcc cgc atc tgc aag ggc gat gag ggt gga gag cgg 1119 Val Ser Arg Ile Ala Arg Ile Cys Gly Asp Glu Gly Gly Glu Arg 335 340 345 350 gtg cta cag cag cgc tgg acc tcc ttc ctc aag gcc cag ctg ctg tgc 1167 Val Leu Gln Gln Arg Trp Thr Ser Phe Leu Lys Ala Gln Leu Leu Cys 355 360 365 tca cgg gat ggc ttc ccc ttc aac gtg ctg cag gat gtc ttc 1215 Ser Arg Pro Asp Asp Gly Phe Pro Phe Asn Val Leu Gln Asp Val Phe 370 375 380 acg ctg agc ccc agc ccc cag gac tgg cgt gac acc ctt ttc Leu Ser Pro Ser Pro Gln Asp Trp Arg Asp Thr Leu Phe Tyr Gly 385 390 395 gtc ttc act tcc cag tgg cac agg gga act aca gaa ggc tct gcc gtc 1311 Val Phe Thr Ser Gln Trp His Arg Gly Thr Thr Glu Gly Ser Ala Val 400 405 410 tgt gtc ttc aca atg aag gat gtg cag aga gtc ttc agc ggc ctc tac 1359 Cys Val Phe Thr Met Lys Asp Val Gln Arg Val Phe Ser Gly Leu Tyr 415 420 425 430 aag gag gtg aac cgt gag aca cag cag tgg tac acc gtg acc cac ccg 1407 Lys Glu Val Asn Arg Glu Thr Gln Gln Trp Tyr Thr Val Thr His Pro 435 440 445 gtg ccc aca ccc cgg cct gga gcg tgc atc acc aac agt gcc cgg gaa 1455 Val Pro Thr Pro Arg Pro Gly Ala Cys Ile Thr Asn Ser Ala Arg Glu 450 455 460 agg aag atc aac tca tcc ctg cag ctc cca gac cgc gtg ctg aac ttc 1503 Arg Lys Ile Asn Ser Ser Leu Gln Leu Pro Asp Arg Val Leu Asn Phe 465 470 475 ctc aag gac cac ttc ctg atg gac ggg cag gtc cga agc cgc atg ctg 1551 Leu Lys Asp His Phe Leu Met Asp Gly Gln Val Arg Ser Arg Met Leu 480 485 490 ctg ctg cag ccc cag gct cgc gc tg cac cgc gtc 1599 Leu Leu Gln Pro Gln Ala Arg Tyr Gln Arg Val Ala Val His Arg Val 495 500 505 510 cct ggc ctg cac cac acc tac gat gtc ctc ttc ctg ggc act ggt gac 1647 Pro Gly Leu His His Thr Tyr Asp Val Leu Phe Leu Gly Thr Gly Asp 515 520 525 ggc cgg ctc cac aag gca gtg agc gtg ggc ccc cgg gtg cac atc att 1695 Gly Arg Leu His Lys Ala Val Ser Val Gly Pro Arg Val His Ile Ile 530 535 535 540 gag gag ctg cag atc ttc tca tcg gga cag ccc gtg cag aat ctg ctc 1743 Glu Glu Leu Gln Ile Phe Ser Ser Gly Gln Pro Val Gln Asn Leu Leu 545 550 555 ctg gac acc cac agg ggg ctg ctg tat gcg gcc tcc 1791 Leu Asp Thr His Arg Gly Leu Leu Tyr Ala Ala Ser His Ser Gly Val 560 565 570 gtc cag gtg ccc atg gcc aac tgc agc ctg tac agg agc tgt ggg gac 1839 Val Gln Val Pro Met Ala Asn Cys Ser Leu Tyr Arg Ser Cys Gly Asp 575 580 585 590 tgc ctc ctc gcc cgg gac ccc tac tgt gct tgg agc ggc tcc agc tgc 1887 Cys Leu Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Gly Ser Ser Cys 595 600 605 aag cac gtc ag cct cag ctg gcc acc agg ccg tgg atc 1935 Lys His Val Ser Leu Tyr Gln Pro Gln Leu Ala Thr Arg Pro Trp Ile 610 615 620 cag gac atc gag gga gcc agc gcc aag gac ctt tgc agc gcg tct tcg 1983 Glu Asp I Gly Ala Ser Ala Lys Asp Leu Cys Ser Ala Ser Ser 625 630 635 gtt gtg tcc ccg tct ttt gta cca aca ggg gag aag cca tgt gag caa 2031 Val Val Ser Pro Ser Phe Val Pro Thr Gly Glu Lys Pro Cys Glu Gln 640 645 650 gtc cag ttc cag ccc aac aca gtg aac act ttg gcc tgc ccg ctc ctc 2079 Val Gln Phe Gln Pro Asn Thr Val Asn Thr Leu Ala Cys Pro Leu Leu 655 660 665 670 tcc aac ctg gcg acc cga cc tc aac ggg gcc ccc gtc aat 2127 Ser Asn Leu Ala Thr Arg Leu Trp Leu Arg Asn Gly Ala Pro Val Asn 675 680 685 gcc tcg gcc tcc tgc cac gtg cta ccc act ggg gac ctg ctg ctg gtg 2175 Ala Ser Ala Ser Cys Leu Pro Thr Gly Asp Leu Leu Leu Val 690 695 700 ggc acc caa cag ctg ggg gag ttc cag tgc tgg tca cta gag gag ggc 2223 Gly Thr Gln Gln Gln Leu Gly Glu Phe Gln Cys Trp Ser Leu Glu Glu Gly 705 710 g 715 ttc ca cag ctg gta gcc agc tac tgc cca gag gtg gtg gag gac ggg 2271 Phe Gln Gln Leu Val Ala Ser Tyr Cys Pro Glu Val Val Glu Asp Gly 720 725 730 gtg gca gac caa aca gat gag ggt ggc agt gta ccc agtc atc 2319 Val Ala Asp Gln Thr Asp Glu Gly Gly Ser Val Pro Val Ile Ile Ser 735 740 745 750 aca tcg cgt gtg agt gca cca gct ggt ggc aag gcc agc tgg ggt gca 2367 Thr Ser Arg Val Ser Ala Pro Ala Gly Gly Lys Ala Ser Trp Gly Ala 755 760 765 gac agg tcc tac tgg aag gag ttc ctg gtg atg tgc acg ctc ttt gtg 2415 Asp Arg Ser Tyr Trp Lys Glu Phe Leu Val Met Cys Thr Leu Phe Val 770 775 780 g ctg gcc gtg cca gtt tta ttc ttg ctc tac cgg cac cgg aac 2463 Leu Ala Val Leu Leu Pro Val Leu Phe Leu Leu Tyr Arg His Arg Asn 785 790 795 agc atg aaa gtc ttc ctg aag cag ggg gaa tgt gcc agc gtg cac gc gc cgc gc gc cgc gc cgc cg cgc Lys Val Phe Leu Lys Gln Gly Glu Cys Ala Ser Val His Pro 800 805 810 aag acc tgc cct gtg gtg ctg ccc cct gag acc cgc cca ctc aac ggc 2559 Lys Thr Cys Pro Val Val Leu Pro Pro Glu Thr Arg Pro Leu Asn Gly 815 820 825 830 cta ggg ccc cct agc acc ccg ctc gat cac cga ggg tac cag tcc ctg 2607 Leu Gly Pro Pro Ser Thr Pro Leu Asp His Arg Gly Tyr Gln Ser Leu 835 840 845 tca gac agc ccc ccg ggg tcc cgagtc act gag tca gag aag agg 2655 Ser Asp Ser Pro Pro Gly Ser Arg Val Phe Thr Glu Ser Glu Lys Arg 850 855 860 cca ctc agc atc caa gac agc ttc gtg gag gta tcc cca gtg tgc ccc 2703 Pro Leu Ser Ile Gln A sp Ser Phe Val Glu Val Ser Pro Val Cys Pro 865 870 875 cgg ccc cgg gtc cgc ctt ggc tcg gag atc cgt gac tct gtg gtg 2748 Arg Pro Arg Val Arg Leu Gly Ser Glu Ile Arg Asp Ser Val Val 880 885 890 tgagagctga cttcc acgctgccct ggcttcaggg gctgtgaatg ctcggagagg 2808 gtcaactgga cctcccctcc gctctgctct tcgtggaaca cgaccgtggt gcccggccct 2868 tgggagcctt ggggccagct ggcctgctgc tctccagtca agtagcgaag ctcctaccac 2928 ccagacaccc aaacagccgt ggccccagag gtcctggcca aatatggggg cctgcctagg 2988 ttggtggaac agtgctcctt atgtaaactg agccctttgt ttaaaaaaca attccaaatg 3048 tgaaactaga atgagaggga agagatagca tggcatgcag cacacacggc tgctccagtt 3108 catggcctcc caggggtgct ggggatgcat ccaaagtggt tgtctgagac agagttggaa 3168 accctcacca actggcctct tcaccttcca cattatcccg ctgccaccgg ctgccctgtc 3228 tcactgcaga ttcaggacca gcttgggctg cgtgcgttct gccttgccag tcagccgagg 3288 atgtagttgt tgctgccgtc gtcccaccac ctcagggacc agagggctag gttggcactg 3348 cggccctcac caggtcctgg gctcggaccc aactcctgga cctttccagc ctgtatcagg 3408 ctgtggccac acgagaggac agcg cgagct caggagagat ttcgtgacaa tgtacgcctt 3468 tccctcagaa ttcagggaag agactgtcgc ctgccttcct ccgttgttgc gtgagaaccc 3528 gtgtgcccct tcccaccata tccaccctcg ctccatcttt gaactcaaac acgaggaact 3588 aactgcaccc tggtcctctc cccagtcccc agttcaccct ccatccctca ccttcctcca 3648 ctctaaggga tatcaacact gcccagcaca ggggccctga atttatgtgg tttttataca 3708 ttttttaata agatgcactt tatgtcattt tttaataaag tctgaagaat tactgttt 3766 <210> 228 <211> 4816 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1) .. (3294) <400> 228 tac act cca gtc atg gcg gcc cga cag gcc gtg ggc agc ggg gct cag 48 Tyr Thr Pro Val Met Ala Ala Arg Gln Ala Val Gly Ser Gly Ala Gln 1 5 10 15 gag aca tgc ggt ctg gat cgg att ttg gag gca ttg aag ctg ctg ctg 96 Glu Thr Cys Gly Leu Asp Arg Ile Leu Glu Ala Leu Lys Leu Leu Leu Leu 20 25 30 agc ccg gga ggc tcg ggc tca agt tca cta cag gtc aca aaa cat gat 144 Ser Gly Gly Ser Ser Ser Leu Gln Val Thr Lys His Asp 35 40 45 gtc ttg ttg gct act tta aaa tct aac ctg tct gct ttg gag gac aag 192 Val Leu Leu Ala Thr Leu Lys Ser Asn Leu Ser Ala Leu Glu Asp Lys 50 55 60 ttt ctg aag gat cct cag tgg aag aat ctg aaa ctc cta aga gat gaa 240 Phe Leu Lys Asp Pro Gln Trp Lys Asn Leu Lys Leu Leu Arg Asp Glu 65 70 75 80 att gct gat aag gca gaa tgg cca caa aac tct gtg gat act tgg 288 Ile Ala Asp Lys Ala Glu Trp Pro Gln Asn Ser Val Asp Val Thr Trp 85 90 95 agt ttt acc tct caa acc ttg ttg ttg ctt ttg tgc ttg aag gaa acc 336 Ser Phe Thr Ser Gln Thr Leu Leu Leu Leu Leu Leu Cys Leu Lys Glu Thr 100 105 1 10 atg atc cgc ctt gca gct aat ttc aat cca ggt aaa ccc aac cct agg 384 Met Ile Arg Leu Ala Ala Asn Phe Asn Pro Gly Lys Pro Asn Pro Arg 115 120 125 act ccg gaa gtt gct cct gcc ctg agc ccc gat gcatt agt atc tca 432 Thr Pro Glu Val Ala Pro Ala Leu Ser Pro Asp Ala Leu Ser Ile Ser 130 135 140 caa cag aag act gtc cag ttc gtt ttg cag ttt gta gtt acc ttg ggt 480 Gln Gln Lys Thr Val Gln Phe Val Leu Gln Phe Val Val Thr Leu Gly 145 150 155 160 atc tgc ccc tat ctc atg cct ggt gtt gga gtc cct ttg aga tat aga 528 Ile Cys Pro Tyr Leu Met Pro Gly Val Gly Val Pro Leu Arg Tyr Arg 165 170 175 act gaa ttt ggt gcc gtc gtt caa gac gtg gtg tgt ttt gat gct gcc 576 Thr Glu Phe Gly Ala Val Val Gln Asp Val Val Cys Phe Asp Ala Ala 180 185 190 ccc gat gca act cga aga ctg tac acc agc tgc aag gcc ctt ctg aat 624 Pro Asp Ala Thr Arg Arg Leu Tyr Thr Ser Cys Lys Ala Leu Leu Asn 195 200 205 gtt gct cag cac aca tct ctg ggg agc ttg atc ttc tgc cac cac ttt 672 Val Ala Gln His Thr Ser Leu Gly Ser Leu Ile Phe Cys His His P he 210 215 220 ggg gat atc gca gca ggt ctg tgc caa ctg gga ttc tgc cca acc aaa 720 Gly Asp Ile Ala Ala Gly Leu Cys Gln Leu Gly Phe Cys Pro Thr Lys 225 230 235 235 240 aga aaa ctg cta aca cct gca gag gtt cta act gaa gag gag aga 768 Arg Lys Leu Leu Thr Pro Ala Glu Glu Val Leu Thr Glu Glu Glu Arg 245 250 255 acc cta tcc agg ggg gcc ttg aga gac atg ctg gat caa gtc tat cag 816 Thr Leu Ser Arg Gly Ala Leu Arg Asp Met Leu Asp Gln Val Tyr Gln 260 265 270 ccc tta gca gtc cgg gaa ctg ctt atc ctc cag gga gga cca ccc cag 864 Pro Leu Ala Val Arg Glu Leu Leu Leu Ile Leu Gln Gly Gly Pro Pro Gln 275 280 285 tcc tgc aca gat gtg aag aca cag atg agg tgt cgg gcc cca gct tgg 912 Ser Cys Thr Asp Val Lys Thr Gln Met Arg Cys Arg Ala Pro Ala Trp 290 295 300 ctt cgg cgt cta tgt gga cag ctg ctc tct gaa agg tta atg cct 960 Leu Arg Arg Leu Cys Gly Gln Leu Leu Ser Glu Arg Leu Met Arg Pro 305 310 315 320 aat ggt gtt cag gca gta gtc cgg ggc att ttg gaa gga gca ggt gcg 1008 Asn Gly Val Gln Ala Val Val Arg Gly Lee Glu Gly Ala Gly Ala 325 330 335 gga gca gct ggt gga agt gat gct gag gtg acg gct gct gac tgg aag 1056 Gly Ala Ala Ala Gly Gly Ser Asp Ala Glu Val Thr Ala Ala Asp Trp Lys 340 345 350 350 aag tgt gac ctg atcca aag att ttg gcc tct tgt ccc cag cag tct 1104 Lys Cys Asp Leu Ile Ala Lys Ile Leu Ala Ser Cys Pro Gln Gln Ser 355 360 365 ctt tca cca gag aat tac tac agg gac atc tgc ccc cag gtt ctg gat 1152 Leu Ser Pro Glu Asn Tyr Tyr Arg Asp Ile Cys Pro Gln Val Leu Asp 370 375 380 tta ttt cac ttt caa gat aaa ttg aca gca cga caa ttt cag aga gtt 1200 Leu Phe His Phe Gln Asp Lys Leu Thr Ala Arg Gln Phe Gln Arg Val 385 390 395 400 gcc acc act acc ttt ata act ttg tca aga gaa cgc cca cat ttg gca 1248 Ala Thr Thr Thr Phe Ile Thr Leu Ser Arg Glu Arg Pro His Leu Ala 405 410 415 gca aag tat ttg ctc cag cca gtg tta gct cct ctt cat cga tgt ttg 1296 Ala Lys Tyr Leu Leu Gln Pro Val Leu Ala Pro Leu His Arg Cys Leu 420 425 430 aat aca gca gag ctt tca gag agt gac atg gta cca gga act att ttg 1344 Asn Thr Ala Glu Leu Ser Glu Ser Asp Met Val Pro Gly Thr Ile Leu 435 440 445 gtg aca gaa gaa gaa ctt agt aga tgc att gag gat gtg ttt aag gtg 1392 Val Thr Glu Glu Glu Glu Leu Ser Arg Cys Ile Glu Asp Val Phe Lys Val 450 455 460 tac gtg gtt ggg aat gaa cct tta aca gtt ttg atg gat tcc ctg ctt 1440 Tyr Val Val Gly Asn Glu Pro Leu Thr Val Leu Met Asp Ser Leu Leu 465 470 475 475 cca gtc ctg gga gtg ctt ttt ctt ctc tac tgt cag agt 1488 Pro Val Leu Gly Val Leu Phe Leu Leu Tyr Cys Phe Thr Lys Gln Ser 485 490 495 gtg tct cac ata agg tca ctt tgc caa gaa atc tta tta tgg att ctg 1536 Val Ser His Ile Arg Ser Leu Cys Gln Glu Ile Leu Leu Trp Ile Leu 500 505 510 ggg aag ctg gaa agg aag aag gca att gcc agc ctg aaa gga ttt gca 1584 Gly Lys Leu Glu Arg Lys Lys Ala Ile Ala Ser Leu Lys Gly Phe Ala 515 520 525 ggg ttgg aaa ggg ttgac ccc tct ctc cat tct ctg tgt cag ttt aga 1632 Gly Leu Asp Lys Ala Val Pro Ser Leu His Ser Leu Cys Gln Phe Arg 530 535 540 gtt gcc act caa ggt ggc att atg att acc atc aaa gag gcc att agt 1680 Val Ala Thr Gln Gly Gly Ile Met Ile Thr Ile Lys Glu Ala Ile Ser 545 550 555 560 gat gaa gat gaa gat gaa gcc ctg tac cag aag gta tcc tct gag cag 1728 Asp Glu Asp Glu Asp Glu Ala Leu Tyr Gln Lys Val Ser Glu Gln 565 570 575 ggc cgg gtg gag cat ctc ggg gac ttg ctg tcc cac tgc cag gaa tgc 1776 Gly Arg Val Glu His Leu Gly Asp Leu Leu Ser His Cys Gln Glu Cys 580 585 590 590 ggt ttg gca gtt gctt tgt ttg aaa gag ttg act cat 1824 Gly Leu Ala Gly Asp Phe Phe Ile Phe Cys Leu Lys Glu Leu Thr His 595 600 605 gtg gcc tcg gaa aat gaa aca gag tta aaa act gag ccc ttc tcc agc 1872 Val Ala Ser Glun Thr Glu Leu Lys Thr Glu Pro Phe Ser Ser 610 615 620 620 aag agc ctc ttg gaa tta gag caa cat cag act ctt ctt gtg gaa ggc 1920 Lys Ser Leu Leu Glu Leu Glu Gln His Gln Thr Leu Leu Val Glu Gly 625 630 635 640 caa gag cgg aag ctg ctt gtc ctg cag ctg atg gct gtt ctg tgc gag 1968 Gln Glu Arg Lys Leu Leu Val Leu Gln Leu Met Ala Val Leu Cys Glu 645 650 650 655 aga atg tct gag cag ata ttc aca aacgt g gtg gac ttt 2016 Arg Met Ser Glu Gln Ile Phe Thr Asn Val Thr Gln Val Val Asp Phe 660 665 670 gta gca gca aca ttg cag aga gcc tgt gca agc ctg gcc cat cag gca 2064 Val Ala Ala Thr Leu Gln Arg Ala Cys Ala Ser Leu Ala His Gln Ala 675 680 685 gag agc acc gtg gaa tca cag acg ctg agc atg tcc atg ggg ctg gtg 2112 Glu Ser Thr Val Val Glu Ser Gln Thr Leu Ser Met Ser Met Gly Leu Val 690 695 700 gct gtc atg cta gga gga gct gtt cag ttg aag tca agt gat ttt gct 2160 Ala Val Met Leu Gly Gly Ala Val Gln Leu Lys Ser Ser Asp Phe Ala 705 710 715 720 gtt ctg aag cag ttg ttg cct ctg ttg gag aag gta tcc aacca Val Leu Lys Gln Leu Leu Pro Leu Leu Glu Lys Val Ser Asn Thr Tyr 725 730 735 cct gat ccg gtc atc caa gaa ctc gct gtt gat ctc cgc atc acc atc 2256 Pro Asp Pro Val Ile Gln Glu Leu Ala Val Asp Leu Arg Ile Thr Ile 740 745 750 tct acc cat gga gcc ttt gcc act gag gcc gtc agc atg gct gcc caa 2304 Ser Thr His Gly Ala Phe Ala Thr Glu Ala Val Ser Met Ala Ala Gln 755 760 765 agt aca ctg aac aga aaa gat ct g gaa ggg aaa ata gaa gag cag caa 2352 Ser Thr Leu Asn Arg Lys Asp Leu Glu Gly Lys Ile Glu Glu Gln Gln 770 775 780 780 caa acc agt cat gaa aga ccc act gat gta gct cat agc cac ctt gaa 2400 Gln Thr Ser His Glu Arg Pro Thr Asp Val Ala His Ser His Leu Glu 785 790 795 800 caa cag cag agc cat gag aca gcc ccc cag aca ggc ctg cag tca aat 2448 Gln Gln Gln Ser His Glu Thr Ala Pro Gln Thr Gly Leu Gln Ser Asn 805 810 815 gct cca atc att cct caa gga gtc aat gag ccc agc act act aca agt 2496 Ala Pro Ile Ile Pro Gln Gly Val Asn Glu Pro Ser Thr Thr Thr Ser 820 825 830 cag aaa tct gga agc gta acc aca gaa cag ctc caa gag gtt ctt ttg 2544 Gln Lys Ser Gly Ser Val Thr Thr Glu Gln Leu Gln Glu Val Leu Leu 835 840 845 tca gct tat gac cct caa att cca aca cgg gct gct gcc ctg cgt act 2592 Ser Ala Tyr Asp Pro Gln Ile Pro Thr Arg Ala Ala Ala Leu Arg Thr 850 855 860 ctt tcc cac tgg ata gag cag aga gaa gca aaa gcc ctt gag atg caa 2640 Leu Ser His Trp Ile Glu Gln Arg Glu Ala Lys Ala Leu Glu Met Gln 865 870 870 875 880 gag aag ctt ctc aag ata ttc ttg gaa aac ttg gaa cat gaa gac act 2688 Glu Lys Leu Leu Lys Ile Phe Leu Glu Asn Leu Glu His Glu Asp Thr 885 890 895 ttt gta tat cta tct gca att cag ggg gtt gcc gct gct 2736 Phe Val Tyr Leu Ser Ala Ile Gln Gly Val Ala Leu Leu Ser Asp Val 900 905 910 tat cct gag aaa atc ttg ccg gac ttg ttg gct caa tat gac agc agc 2784 Tyr Pro Glu Lys Ile Leu Pro Asp Leu Leu Ala Tyr Asp Ser Ser 915 920 925 aaa gac aag cac aca cca gag acc aga atg aaa gtc ggg gaa gtc ctt 2832 Lys Asp Lys His Thr Pro Glu Thr Arg Met Lys Val Gly Glu Val Leu 930 935 940 atg cga atc gtc agg gca tta gga gac atg gtc tca aag tac cga gaa 2880 Met Arg Ile Val Arg Ala Leu Gly Asp Met Val Ser Lys Tyr Arg Glu 945 950 955 960 cct ttg atc cat acc ttc ctg agg gga gtg aga gat cct gat ggt gct 2928 Pro Leu Thr Phe Leu Arg Gly Val Arg Asp Pro Asp Gly Ala 965 970 975 cac agg gcc agc agc ttg gcc aac ctt ggg gag ctg tgc cag agg ctg 2976 His Arg Ala Ser Ser Leu Ala Asn Leu Gly Glu Leu Cys Gln Arg Leu 980 985 990 gac ttt ctg ctg ggc tcc gtg gtc cat gag gta aca gct tgc ctg att 3024 Asp Phe Leu Leu Gly Ser Val Val His Glu Val Thr Ala Cys Leu Ile 995 1000 1005 gct gtg gcc aaa aca gat ggt gata gtt ca cgc aga gct gcc ata 3072 Ala Val Ala Lys Thr Asp Gly Glu Val Gln Val Arg Arg Ala Ala Ile 1010 1015 1020 cat gtg gtt gtg ctg ctg ctt cgg gga ctc agc cag aaa gct act gag 3120 His Val Val Val Leu Leu Leu Arg Gly Leu Ser Gln Lys Ala Thr Glu 1025 1030 1035 1040 gtg ctg agc gcc gtc ctc aag gat ctc tac cac ctg ctg aag cac gta 3168 Val Leu Ser Ala Val Leu Lys Asp Leu Tyr His Leu Leu Lys His Val 1045 1050gtt ctg gag ccc gat gac gtg gcc aag ctt cat gcc cag ttg gcc 3216 Val Cys Leu Glu Pro Asp Asp Val Ala Lys Leu His Ala Gln Leu Ala 1060 1065 1070 cta gaa gag ctg gat gac atc atg aaa aac ttc ctg cattc 3264 Leu Glu Glu Leu Asp Asp Ile Met Lys Asn Phe Leu Phe Pro Pro Gln 1075 1080 1085 aag ctg gag aag aag atc atg gtc ctg ccg tagacctggc tccaaggacg 3314 Lys Leu Glu Lys Lys Ile Met Val Leu Pro 1090 1095 tggaggaggc aggcagggcc aggcacccag agccgtgccc aggtcttcca gcaggtggcc 3374 ctgctgcctc ttgagtgctg gcagcatggc tgaccctcgg ggtggtttta tggtgcaggt 3434 cacttgggtc ttcagggtcc cttccgaggg catgtgttca gcactcccgc gttcagcctg 3494 aggggtgtac agttaagaga agacagttac agatctcatt aatctacatt tttcactgtc 3554 ctctagcatt gaaagaagga tgtctacctg gtgaaagtat attttaacat gactgatgga 3614 atttcactaa ttgcccactc tcttggaact tgaggagaag cggttggcca cccatatgtc 3674 acctagctct atattctttc aggctgagat tcttcttcag gaaaatgagg agcagaactg 3734 gccacccttg gctgctcaag aggcatttca gagtaggaga tgcagttgga ggtggggagg 3794 ggaaggaaat agttatcaaa taatgcaaaa tggaataaag ttatcttgga tggaaagaac 3854 agggctaaat ctggtcctct ggtgtcgaga tggaaaactg tggagttgaa gaggctctga 3914 tgcccagaaa ggacaatcaa gctggttgac tcttccagag aagaagggta agccctgtat 3974 ttatcctccc aggccattct tcttcactcc tgctgctgtt tgcagagagt tgccctgatt 4034 atcaggagaa aagaaccacg agcatccaga gagtttacat cctgccttct gtcctctgct 4094 ccttcagaaa gatgaatgcc tagacaatgg gttcacactg aatgcaggct ggaaagaatg 4154 catgctggtg gcctaatgcc agggctgttg aaacaatttc agatatagca ctgtggtctc 4214 cactttattt ctttatatgt tttggccgct gcattttgat tgcagctaaa agagataaca 4274 gaaaggagat actggctggc tgcttcatat tagccctctc tgttgtcaac accttgatga 4334 ggccaaccca gagatgcttg atcagtcctc agctttgcag ggctaggtac agaattttat 4394 cacaggattt tatcacgctc tctggggtga ctagatccac aggaaccaaa acgcagtttc 4454 caaaagctcg agtgactgaa ggatctatac acaaacatgg ctatttgcta gttaacaaca 4514 ggatatttct ctctggccag atcacagaca tggttctgag tcagatcttc cttggtggca 4574 tccctttaaa gaggccatct tatgaacagg atcacaagtg agcttagtga gcagagagtt 4634 agaacaaatc tagctaggtg tgtttaagga atatttccat tcagctagtg tagctggatt 4694 aatttctatt ctccaaatca aggatgtcta gaaaatgggc attgtggctt tcaaatctaa 4754 gaagaatctc ctttgggcca gctggatgta caataaaaat gcttgtttct tggccttcct 4814 tt 4816 <210> 229 <211> 4371 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (2132) <400> 229 ct gat gct gat aaa ttg aag aag aaa aca gct gag gac aga acg cag 47 Asp Ala Asp Lys Leu Lys Lys Lys Thr Ala Glu Asp Arg Thr Gln 1 5 10 15 gca ttt cac ctg cgg cag aac ctg agc gcc ctg gat aag atg cat gag 95 Ala Phe His Leu Arg Gln Asn Leu Ser Ala Leu Asp Lys Met His Glu 20 25 30 gag caa gag ctt ttc act gag aag atg aga ggg gag ctg cgc gcc tgt 143 Glu Gln Glu Leu Phe Thr Glu Lys Met Arg Gly Glu Leu Arg Ala Cys 35 40 45 cgg cag agg cgg gac ctg atc gac aag cag cag gag gct gtg gca gcc 191 Arg Gln Arg Arg Asp Leu Ile Asp Lys Gln Gln Glu Ala Val Ala Ala 50 55 60 gag atc gcc aca gag gaa gag gcg ggc aac atg gcc gct gtg ggc cgc 239 Glu Ile Ala Thr Glu Glu Glu Ala Gly Asn Met Ala Ala Val Gly Arg 65 70 75 ctc cag gcc gtg tcc aga cgc cta ttt gca gag gag gag 287 Leu Gln Ala Val Ser Arg Arg Leu Phe Ala Glu Leu Glu Asn Glu Arg 80 85 90 95 gac ctg cag tcg agg act gag gcc gtg ctg aag gag agc gag aac acc 335 Asp Leu Gln Ser Arg Thr Glu Ala Val Leu Lys Glu Ser Glu Asn Thr 100 105 110 atg tgg cac atc gag atc cag gag ggg cga ctc gag gcc ttc cgg aca 383 Met Trp His Ile Glu Ile Gln Glu Gly Arg Leu Glu Ala Phe Arg Thr 115 120 125 gct gac cgt gag gag gtg gag gcc acg ggg cgg cgg gtc cag cgc 431 Ala Asp Arg Glu Glu Val Glu Ala Thr Gly Arg Arg Leu Gln Val Arg 130 135 140 gca gcc gag cag ctc tgc aga gag cag gag gcc ctg ggg aag gtg gag 479 Ala Ala Glu Gln Leu Cys Arg Glu Glu Glu Ala Gly Lys Val Glu 145 150 155 cgg aac cga ctg ctg agg atc agg aag tcc ctg aac acc cag aag gag 527 Arg Asn Arg Leu Leu Arg Ile Arg Lys Ser Leu Asn Thr Gln Lys Glu 160 165 170 175 ctc ggg ctc agg cac aag ctg ctg gag gac gcc cgg aag aac cac 575 Leu Gly Leu Arg His Gln Lys Leu Leu Glu Asp Ala Arg Lys Asn His 180 185 190 aag gtt gcc gtg cgg ttc ctg aag gcc tcc ctg gga aga atc cga gag 623 Lys Val Arg Phe Leu Lys Ala Ser Leu Gly Arg Ile Arg Glu 195 200 205 caa gag aag aag gag gag atg gag tgc cac gag tac atg agg cga cgc 671 Gln Glu Lys Lys Glu Glu Mlu Get Glu Cys His Glu Tyr Met Arg Arg Arg 21 0 215 220 atg gat gcg gtg gtg gcg ctg aag ggc agc atc tcc gcg aac cgg gac 719 Met Asp Ala Val Val Ala Leu Lys Gly Ser Ile Ser Ala Asn Arg Asp 225 230 235 aca ctg cgg aag ttc caa gca tgg aag gca gag ctg gcg 767 Thr Leu Arg Lys Phe Gln Ala Trp Asp Arg Ala Lys Ala Glu Leu Ala 240 245 250 255 gag cag agg gtc cag gct gag aag aag gcg att ctg gcc cag ggc agg 815 Glu Gla Glu Gln Gln Lys Lys Ala Ile Leu Ala Gln Gly Arg 260 265 270 gat gca ttc agg cac ctt gtc cac cag cgc cgg cgc cag gag ctg gag 863 Asp Ala Phe Arg His Leu Val His Gln Arg Arg Arg Gln Glu Leu Glu 275 g 280 280 g aag agg gcc ttt gag gag gag cag aag ctc aga aag cag gag 911 Ala Gln Lys Arg Ala Phe Glu Glu Glu Gln Lys Leu Arg Lys Gln Glu Glu 290 295 300 atc atc agt cgg att ctg aaa gag gag gct ag ag ag aa ag 959 Ile Ile Ser Arg Ile Leu Lys Glu Glu Ala Glu Glu Glu Lys Arg Lys 305 310 315 aaa cag cat ccc ccc acc agt gcc agg cac cgg ctg acc ctg agg gac 1007 Lys Gln His Pro Pro Thr Ser Ala Arg His Arg Leu Thr L eu Arg Asp 320 325 330 335 aag acc tgg aac tac att tct gac ttt tgc aag aag acc aca gtc cca 1055 Lys Thr Trp Asn Tyr Ile Ser Asp Phe Cys Lys Lys Thr Thr Val Pro 340 345 350 350 acc aac acg tac aca ctg gac tac gag gct gct gca ggc ccc ggg ccc 1103 Thr Asn Thr Tyr Thr Leu Asp Tyr Glu Ala Ala Ala Gly Pro Gly Pro 355 360 365 tct cgg ttg ctg gaa gtc gtt tcc agt gag ctt atc cag ggg gac ccc 1151 Ser Arg Leu Leu Glu Val Val Ser Ser Glu Leu Ile Gln Gly Asp Pro 370 375 380 ggg gcc agc tca gag gag gaa acg tta gct gag ccc gag atc tct ggg 1199 Gly Ala Ser Ser Glu Glu Glu Glu Thr Leu Ala Glu Pro Glu Ile Ser Gly 385 390 395 ctt tgg aat gaa gac tac aag cca tac cag gtg ccc aag gag gac gtg 1247 Leu Trp Asn Glu Asp Tyr Lys Pro Tyr Gln Val Pro Lys Glu Asp Val 400 405 410 415 gac cga aag ccc gtg ggc ggg aca aag atg gac gac atc ctg gag 1295 Asp Arg Lys Pro Val Gly Gly Thr Lys Met Asp Lys Asp Ile Leu Glu 420 425 430 cgc acg gtg gag cgg ctg cgg agc agg gtg gtc cac aag cag gtg gtg 1343 Arg Thr Val Glu Arg Leu r Arg Val Val His Lys Gln Val Val 435 440 445 tgg ggg cgt gag ttc caa gga cgc ccc ttc aac agc aaa ccg gag ctc 1391 Trp Gly Arg Glu Phe Gln Gly Arg Pro Phe Asn Ser Lys Pro Glu Leu 450 455 460 ctc cac ttc cag gac ttt gat att ggc aaa gtg tac aag aaa aag atc 1439 Leu His Phe Gln Asp Phe Asp Ile Gly Lys Val Tyr Lys Lys Lys Ile 465 470 475 acg ttg gta aac acc acc tac acg atc aac tac tgc agct gg 1487 Thr Leu Val Asn Thr Thr Tyr Thr Ile Asn Tyr Cys Lys Leu Val Gly 480 485 490 495 gtg gag gag cac ctc cgg gac ttc atc cac gtt gac ttt gac ccc cct 1535 Val Glu Glu His Leu Arg Asp Phe Ile His Val Asp Phe Asp Pro Pro 500 505 510 ggc ccc ctg tca gcc gga atg tcc tgt gaa gtg ctt gtc acc ttc aag 1583 Gly Pro Leu Ser Ala Gly Met Ser Cys Glu Val Leu Val Thr Phe Lys 515 520 525 ccg atg ata atac aag gat cta gaa gga aat atc tca ttt ttg gct cag 1631 Pro Met Ile Asn Lys Asp Leu Glu Gly Asn Ile Ser Phe Leu Ala Gln 530 535 540 acg ggc gag ttt tca gtt cca ctg aaa tgt tca aca aag aaa tgt tcg 1679 Thr u Phe Ser Val Pro Leu Lys Cys Ser Thr Lys Lys Cys Ser 545 550 555 ctg tcc ctc gac aag gag ctc att gac ttc ggc agc tac gtg gta gga 1727 Leu Ser Leu Asp Lys Glu Leu Ile Asp Phe Gly Ser Tyr Val Gly 560 565 570 575 gag acc acg tct cgg acc atc acg ctg acc aac gtt ggg ggc ttg ggc 1775 Glu Thr Thr Ser Arg Thr Ile Thr Leu Thr Asn Val Gly Gly Leu Gly 580 585 590 acg act ttc aag ttc ctg cca gct tca gag ccc tgt gag atg gac gac 1823 Thr Thr Phe Lys Phe Leu Pro Ala Ser Glu Pro Cys Glu Met Asp Asp 595 600 605 tcc cag tct gcc ctg aaa tta agc agt ctc ctg acc tac gaa gat aaa 1871 Ser Gln Ser Ala Leu Lys Leu Ser Ser Leu Leu Thr Tyr Glu Asp Lys 610 615 620 agc ttg tat gac aaa gcc gcc acc agc ttc tct gag cag cag cta gag 1919 Ser Leu Tyr Asp Lys Ala Ala Thr Ser Phe Ser Glu Gln Gln Leu Glu 625 630 630 635 ggc acg gag tcc tcc cag gcg gac atg cag agc cgg aag gag ctg gag 1967 Gly Thr Glu Ser Ser Gln Ala Asp Met Gln Ser Arg Lys Glu Leu Glu 640 645 650 655 aag ctg gac aag gag cag gag gag gag cag ccc gca ggt cca ggc 2015 Lys Leu Asp Lys Glu Gln Glu Glu Glu Gln Pro Ala Gly Glu Pro Gly 660 665 670 tgc cag gcc aag cca ggg tgg gcg ggc ggt gag ggc ctc agg gca gca 2063 Cys Gln Ala Lys Pro Gly Grp Gla Gly Gly Leu Arg Ala Ala 675 680 685 ttc cag ggg gct gag ggg ccc agg gga ggg ctg gaa agt aga gaa ttt 2111 Phe Gln Gly Ala Glu Gly Gly Pro Arg Gly Gly Leu Glu Ser Arg Glu Phe 690 695 700 tcc cag gcc ttc aag tgacggttaa gcaagaaaat attcttatgt 2162 Ser Gln Ala Phe Asp Val Lys 705 710 gccactaagt gttgtttttg gagtggacga aaatgtacat tcacgttgac gctaaccgaa 2222 gacttgaagg cacctccagc attggcccag caggcccagc acgggcggag ccgcacaggg 2282 cggggaagag gctctgcggt gccccctgga ggggccgggc tgcggggggc ttctgtctag 2342 ctctgcagct gtggctgttg ttagacgcgc accagcgggg agaggtgccg agaaacgggc 2402 gggccctgcc ctccccatgc ctcctgccct gcagcccgcc gccatcggga atcgcttgcg 2462 tctcctcctt gcttctcttg atcgttttcc cacatacgca tcgagatcca gaaacctccg 2522 tcctcctcct gtctgtcttc gcgtggtgcg cgttccgcac gccctgcagc tcagcgcgga 2582 gctgggccgg ttctccacag cctgtgtgag cctcacttcc ggtgtgagcc gcacttccgg 2642 tgtgagccgc acttcctgtc ctcaccactg cgtggcgttt cctttcctga gagagcctcg 2702 ggttctagat ccgtccttct gccagtgcgc acttgggagc gttcgtggta cacactgttg 2762 cgaaggcggc tgttctgcac tgccccttgg cctgtgtgtg agttcccaca gggcacctgg 2822 ctggggctca tgcctgcatc acagggcata gccagcctca ctggcatcag ctaataccaa 2882 agtgagttct ttttctattg agacagggtc tcgctctgtc gcctaggctg gagtgcagtg 2942 gtgcggtcac agctcactgc ggcctcggcc tcccgggctc aagcaatcct cctgcctcag 3002 ctcctcagtg gctggaactg caggcacgca ccaccgcacc tggctagttt ttgtattttt 3062 ttgtggacac ggggtttcgc catgtttccc gggctggtgt ggaactcctg aactcgggct 3122 gtctgcccgc ctcggcctcc cagggtgctg gattacaggc atgagccacc tcgcctagcc 3182 caccgagttc tttttcaaag tggttgtgca agtttacact cccaccaaca gtgtacaaga 3242 ctgtgctgtc cagcgtggct gtcactgcca catctggcta tttaaactta aattgatcca 3302 aattaaataa tagtgaaaat tcaggtcctc ctccacaagg gccacatttc atatgctcca 3362 tagcgacctg tgggcaacgg ctgccctact ggacagccca gaagcccagc tctgcctggt 3422 cacagagggt cctacggggc cacac tgggc ttgagggcct tgcttcacat ccgcaggagc 3482 acgaggtcac acggcccggg gctgcatgtc tggggggcct gcaccacggt ctgctgttga 3542 gatgttgctt tttggtttcc cagatcacca gtgagattgc gtgtctttcc ctgggcccat 3602 ttacaagttg tatcttcttt ggtgtgacat ctctgtttaa ggctatccct tgttcttctg 3662 tgggattgtc tgtcttcttc tcattcattc ataggagctc ttcatgcacc cagattccag 3722 ccctcctccc tgaggaatgt tgcaggtgct gcctccgagt ctgtggctgg gccttcctct 3782 ccctttatga cgtcttttct caaatcaaag ttcttcagtc cagtctttgc atatttacca 3842 gtcatttcta ttggaatttg ttttttatga tttttaggca atttttttct cctccagggt 3902 cataaagaca taggacatcg cttttgtgtt gaggtgtatg atccacctca aattcactcc 3962 tgcttgtggt ggaagtcagg gctgaggctc atttcccctg gtgcgtgttt gtgtattcca 4022 cggcacaagt ggactctgct atcccattcg atccattcgt tgtccgtgtc aaaaatcaat 4082 tgaccatcca ggcacagtgg ctcatgcctg taatcccaga actttgggag gccgaggcgg 4142 gaggatcact tgaggtcagg agtttgagac cagcctggcc aacatggtga aaccccattt 4202 ctactaaaaa tgcaaaaaat tagccaggcg tggtggcggg tgcctgtagt cccagctact 4262 tgggtggctg aggcaggaga attgcttgag cccgggaggc ggaggttgca gtgagctgag 4322 atcgcgccat tgcactccag cctggcctat aagagtgaaa tactgtctc 4371 <210> 230 <211> 4420 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (460) .. (3270) <400> 230 caaaaacttg gaaggaaatc atgaccagca tggcagaaac agccttcttg catcatatat 60 tcattatgtt ttccgcctac caaatactta ccctaattca tcatcaccag gtcctggggg 120 tttgggagga tcagtgcatt atgccacaat ggctagatct gcggtgagac ctgcaagcct 180 taatttaaat cgttctcgaa gccttagtaa tagcaatcca gatatatctg ggactcccac 240 gtcaccagat gatgaagttc gatcaatcat cgggagtaag ggtttagatc gctccaattc 300 ctgggttaac actggtggtc caaaagctgc cccatgggga tccaacccca gtccaagtgc 360 agaatcaaca caggctatgg atcgaagttg taatcgtatg tcttcgcaca cagagacgtc 420 aagtttctta caaacattaa cgggacgctt accaactaa aaa gct ttt tca cga 474 Lys Ala Phe Ser Arg 1 5 gga gct ggc ttt gca gtg ggt tgt tgc agt ggc ag Ag La Gly Asa Ga Gly Asa G ga Gly Asa Gag Alya G G Arg Glu Ser 10 15 20 gct ttg caa caa gcc tgg ttc ttt ttt gaa tta atg gta aag agc atg 570 Ala Leu Gln Gln Ala Trp Phe Phe Phe Glu Leu Met Val Lys Ser Met 25 30 35 gtg cac cat tta tac ttt aat gat aaa ctt gag gct cca agg aaa agt 618 Val His His Leu Tyr Phe Asn Asp Lys Leu Glu Ala Pro Arg Lys Ser 40 45 50 cgt ttt cca gaa cgt ttc atg gat gac att gca gct ctt gtc agc acg 666 Arg Phe Pro Glu Arg Phe Met Asp Asp Ile Ala Ala Leu Val Ser Thr 55 60 65 att gct agt gat ata gtt tca cga ttt cag aag gac aca gaa atg gtt 714 Ile Ala Ser Asp Ile Val Ser Arg Phe Gln Lys Asp Thr Glu Met Val 70 75 80 85 gag aga ctc aat aca agc ctt gca ttc ttt ctc aat gat ctg ttg tct 762 Glu Arg Leu Asn Thr Ser Leu Ala Phe Phe Leu Asn Asp Leu Leu Ser 90 95 100 gtt atg gac aga gga ttt gtt ttt agc ctt ata aag tcc tgc tat aaa 810 Val Met Asp Arg Gly Phe Val Phe Ser Leu Ile Lys Ser Cys Tyr Lys 105 110 115 cag gtg tct tca aag ctt tac tca tta ccg aat ccc agt gtt ctg gtg 858 Gln Val Ser Ser Lys Leu Tyr Ser Leu Pro Asn Pro Ser Val Leu Val 120 125 130 tcc ttg agg ctg gat ttt cta cga atc atc tgc agt cat gag cac tat 906 Ser Leu Arg Leu Asp Phe Leu Arg Ile Ile Cys Ser His Glu His Tyr 135 140 145 gtt aca tta aac tta ccc tgc agc tta ctt act cca cct gca tct cca 954 Val Thr Leu Asn Leu Pro Cys Ser Leu Leu Thr Pro Pro Ala Ser Pro 150 155 160 165 tca cct tct gtt tct tct gca aca tct cag agt tct gga ttt tct acg 1002 Ser Pro Ser Val Ser Ser Ala Thr Ser Gln Ser Ser Gly Phe Ser Thr 170 175 180 aat gta caa gac caa aag att gca aat atg ttt gaa tta tcc gtg cct 1050 Asn Val Gln Asp Gln Lys Ile Ala Asn Met Phe Glu Leu Ser Val Pro 185 190 195 ttc cgc caa cag cat tat ttg gca gga ctt gtg tta aca gag ctg gct 1098 Phe Argyr Gln Leu Ala Gly Leu Val Leu Thr Glu Leu Ala 200 205 210 gtc att tta gac cct gat gct gaa gga ctg ttt gga ttg cat aag aaa 1146 Val Ile Leu Asp Pro Asp Ala Glu Gly Leu Phe Gly Leu His Lys Lys 215 220 225 gtc atc aat atg gta cac aat tta ctc tcc agt cac gac tca gac ccg 1194 Val Ile Asn Met Val His Asn Leu Leu Ser Ser His Asp Ser Asp Pro 230 235 240 245 cgg tac tct gac cct cag ata aag gct cga gtg gcc atg ttg tat cta 1242 Arg Tyr Ser Asp Pro Gln Ile Lys Ala Arg Val Ala Met Leu Tyr Leu 250 255 260 cct ctg att ggt att atc atg gaa act gta cct cag ctg tat gat ttt 1290 Pro Leu Ile Gly Ile Ile Met Glu Thr Val Pro Gln Leu Tyr Asp Phe 265 270 275 aca gaa act cac aat caa cga gga aga cca att tgt ata gcc act gat 1338 Thr Glu Thr His Asn Gln Arg Gly Arg Pro Ile Cys Ile Ala Thr Asp 280 285 290 290 gat tat gaa agt gag agc gga agt atg ata agc cag acc gtt gcc atg 1386 Asp Tyr Glu Ser Glu Ser Gly Ser Met Ile Ser Gln Thr Val Ala Met 295 300 305 gca atc gca ggg aca tcg gtc cct caa cta aca agg cct ggc agt ttc 1434 Ala Ile Ala Gly Thr Ser Val Pro Gln Leu Thr Arg Pro Gly Ser Phe 310 315 320 325 ctc ctc acg tca acg agt ggc agg caa cac act acc ttt tca gca gaa 1482 Leu Leu Thr Ser Thr Ser Gly Arg Gln His Thr Thr Phe Ser Ala Glu 330 335 340 tca agt cga agc ctt ttg atc tgt cta ctt tgg gtt ctc aaa aat gca 1530 Ser Ser Arg Ser Leu Leu Ile Cys Leu Leu Trp Val Leu Lys Asn Ala 345 350 355 gat gaa aca gtt cta cag aag tgg aca gat ctc tca gtc ttg cag 1578 Asp Glu Thr Val Leu Gln Lys Trp Phe Thr Asp Leu Ser Val Leu Gln 360 365 370 cta aac cgg cta tta gat ctg ctt tat ctc tgt gtg tct tgc ttt gag 1626 Leu Asn Arg Leu Leu Asp Leu Leu Tyr Leu Cys Val Ser Cys Phe Glu 375 380 385 tat aaa ggg aaa aaa gtg ttt gaa cga atg aat agc ttg acc ttt aag 1674 Tyr Lys Gly Lys Lys Val Phe Glu Arg Met Asn Ser Leu Thr Phe Lys 390 400 405 aaa tca aaa gac atg aga gca aag ctt gaa gaa gct att ctt ggg agc 1722 Lys Ser Lys Asp Met Arg Ala Lys Leu Glu Glu Ala Ile Leu Gly Ser 410 415 420 ata ggt gcc agg caa gaa atg gta cgg cgag gga cag ctc gag 1770 Ile Gly Ala Arg Gln Glu Met Val Arg Arg Ser Arg Gly Gln Leu Glu 425 430 435 aga agc cca tct gga agt gcc ttt gga agt caa gaa aat ttg agg tgg 1818 Arg Ser Pro Ser Gly Ser Ala Phe Ser Gln Glu Asn Leu Arg Trp 440 445 450 agg aaa gat atg act cac tgg cgt caa aac aca gag aag ctt gac aaa 1866 Arg Lys Asp Met Thr His Trp Arg Gln Asn Thr Glu Lys Leu Asp Lys 455 460 465 tca aga gca gag att gaa cac gaa gca ctg att gat gga aac ctg gct 1914 Ser Arg Ala Glu Ile Glu His Glu Ala Leu Ile Asp Gly Asn Leu Ala 470 475 480 485 485 aca gaa gca aac cta atc att tta gat aca tta gag att gtt ag 1962 Thr Glu Ala Asn Leu Ile Ile Leu Asp Thr Leu Glu Ile Val Val Gln 490 495 500 acc gtt tct gta acg gaa tcc aaa gag agc att ctt ggt gga gtg cta 2010 Thr Val Ser Val Thr Glu Ser Lys Glu Ser Ile Leu Gly Gly Val Leu 505 510 515 aaa gtg cta cta cac agc atg gcc tgt aac caa agt gca gtt tat cta 2058 Lys Val Leu Leu His Ser Met Ala Cys Asn Gln Ser Ala Val Tyr Leu 520 525 530 caa cac tgt ttt gct aca cag aga gcc ttg gtt tca aag ttt cct gaa 2106 Gln His Cys Phe Ala Thr Gln Arg Ala Leu Val Ser Lys Phe Pro Glu 535 540 545 ctc tta ttt gaa gaa gag aca gag cag tgt gct gat tta tgc ctc Pgg Leu Leu Glu Glu Thr Glu Gln Cys Ala Asp Leu Cys Leu Arg 550 555 560 565 ctt ctc cga cac tgt agc agt agc atc ggt aca ata cgg tca cac gcc 2202 Leu Leu Arg His Cys Ser Ser Ser Ile Gly Thr Ile Arg Ser His Ala 570 575 580 agt gcc tcc ctt tac cta cta atg agg caa aac ttt gag att ggg aat 2250 Ser Ala Ser Leu Tyr Leu Leu Met Arg Gln Asn Phe Glu Ile Gly Asn 585 590 595 aac ttt gcc agg gtt aaa atg cag gta aca at g tca cta tcc tcc ttg 2298 Asn Phe Ala Arg Val Lys Met Gln Val Thr Met Ser Leu Ser Ser Leu 600 605 610 gtg ggc aca tct cag aat ttt aat gaa gaa ttc tta aga cgt tct cta 2346 Val Gly Thr Ser Gln Asn Phe Asn Glu Glu Phe Leu Arg Arg Ser Leu 615 620 625 aag act ata ttg aca tat gct gaa gaa gat ctg gaa ttg agg gaa aca 2394 Lys Thr Ile Leu Thr Tyr Ala Glu Glu Asp Leu Glu Leu Arg Glu Thr 630 635 640 ttt cct gat cag gtc cag gat ctg gtt ttc aat ctc cat atg att 2442 Thr Phe Pro Asp Gln Val Gln Asp Leu Val Phe Asn Leu His Met Ile 650 655 660 ctt tct gat act gtg aaa atg aag gaa cac cag gag gat cct atg 2490 Leu Ser Asp Thr Val Lys Met Lys Glu His Gln Glu Asp Pro Glu Met 665 670 675 ttg att gat cta atg tac aga att gcc aag ggt tac cag acc tct cca 2538 Leu Ile Asp Leu Met Tyr Arg Ile Ala Lys Gly Tyr Gln Thr Ser Pro 680 685 690 gat ctg cga ttg acc tgg ttg cag aac atg gca ggc aag cac tca gaa 2586 Asp Leu Arg Leu Thr Trp Leu Gln Asn Met Ala Gly Lys His Ser Glu 695 700 705 cga agc aat cat gct ga a gct gca cag tgt cta gtc cac tca gca gca 2634 Arg Ser Asn His Ala Glu Ala Ala Gln Cys Leu Val His Ser Ala Ala 710 715 720 725 ctt gtt gct gaa tat ttg agc atg ctg gag gac cgg aaa tat ctt cct 2682 Le Val Ala Glu Tyr Leu Ser Met Leu Glu Asp Arg Lys Tyr Leu Pro 730 735 740 gtg gga tgt gta aca ttt cag aat att tca tct aat gtt tta gaa gaa 2730 Val Gly Cys Val Thr Phe Gln Asn Ile Ser Ser Asn Val Leu Glu Glu 745 750 755 tct gcg gtc tca gat gat gtg gta tct cca gat gaa gaa ggt atc tgc 2778 Ser Ala Val Ser Asp Asp Val Lu Ser Pro Asp Glu Glu Gly Ile Cys 760 765 770 tct gga aaa tac ttt act gag tca ggatt gtg gga tta ctg gaa caa 2826 Ser Gly Lys Tyr Phe Thr Glu Ser Gly Leu Val Gly Leu Leu Glu Gln 775 780 785 gca gct gct tcc ttc tct atg gct ggc atg tat gaa gca gtt aat gaa 2874 Ala Ala Ala Serhe Ala Gly Met Tyr Glu Ala Val Asn Glu 790 795 800 805 gtt tac aaa gta ctt att cct att cat gaa gct aat cgg gat gca aag 2922 Val Tyr Lys Val Leu Ile Pro Ile His Glu Ala Asn Arg Asp Ala Lys 810 815 82 0 aaa cta tcc aca att cat ggt aaa ctt caa gaa gca ttc agc aaa att 2970 Lys Leu Ser Thr Ile His Gly Lys Leu Gln Glu Ala Phe Ser Lys Ile 825 830 835 gtt cat cag agt act ggc tgg gag cgg atg ttt ggc acc tat ttt cgt 3018 Val His Gln Ser Thr Gly Trp Glu Arg Met Phe Gly Thr Tyr Phe Arg 840 845 850 gtt ggt ttt tat gga acc aag ttc ggg gat ttg gat gaa caa gaa ttt 3066 Val Gly Phe Tyr Gly Thr Lys Phe Gly Asp Leu Asp Glu Gln Glu Phe 855 860 865 gtt tac aag gag cct gca ata acc aaa ctt gca gag ata tct cac aga 3114 Val Tyr Lys Glu Pro Ala Ile Thr Lys Leu Ala Glu Ile Ser His Arg 870 875 880 885 885 ttg gag tgg atg gac cgg aag cat tgg gtt cac ctg gga gat tgt ttg 3162 Leu Glu Trp Met Asp Arg Lys His Trp Val His Leu Gly Asp Cys Leu 890 895 900 aaa tgc aga acc tca gac ccc acc cca gcc cct gtg aat caa agt ctg 3210 Lyc Cys Arg Thr Ser Asp Pro Thr Pro Ala Pro Val Asn Gln Ser Leu 905 910 915 cat ttt aac aag atc ccc agg gat ttt acg gag aaa gat ttg gag agg 3258 His Phe Asn Lys Ile Pro Arg Asp Phe Thr Glu Lys Asp Leu Glu Arg 920 925 930 atg tgg ttg aag taatcaaaga ctctaatcct gtagacaagt gtaaattaga 3310 Met Trp Leu Lys 935 tcctaacaag gcatatattc agattaccta tgtggagcca tactttgaca catatgagat 3370 gaaggacaga atcacctatt tcgacaaaaa ttacaatctt cgtcgattca tgtactgtac 3430 accctttact ttagatggcc gtgcccatgg ggaacttcat gaacaattca aaaggaagac 3490 cattctgact acgtctcatg cctttcctta tattaaaaca agggtcaatg tcactcataa 3550 agaagagatc atcttaacac caattgaagt tgctattgag gacatgcaga aaaagacaca 3610 ggagttggca tttgcaacac atcaggatcc cgcagacccc aaaatgcttc agatggtact 3670 ccagggatct gtaggcacca cagtgaatca ggggcctttg gaagttgccc aggtttttct 3730 gtctgaaata cctagtgacc caaagctctt cagacatcat aataaactgc gactctgctt 3790 taaagatttt actaaaaggt gtgaagatgc cttaagaaaa aataagagct taattgggcc 3850 ggatcaaaag gagtatcaaa gggaactgga gagaaactat catcgcctta aagaggccct 3910 acagccactg atcaacagaa agatccctca gttatacaag gcagtattgc ctgtcacctg 3970 ccacagagat tccttcagtc gaatgagcct tcgcaaaatg gatctctaaa ctgaatgcac 4030 ttgttttatt catctgcaaa gagccatgta ttcaacat cg agtgtgaaaa gatctattgg 4090 aaaacaacat ggaatggaat tctggaaatt attattcatt gaagaatgca gtggccaaga 4150 aaatatcaaa tgtagattgt taacgcttga gaatcatggc tatggtttct aatgttctgg 4210 taacaagctg ttatctttta agacatttta atgactcaaa ggtacactat acatttacca 4270 ttatttatac catagctaag gttaaaaatt tattcacttt aagttcgtat tttttaattt 4330 atattaccat ttatagattc attttggaac cattttaaat gtagtaatgc ttattttaaa 4390 ggtactatta aatatgtgaa tgtttacact 4420 <210> 231 <211> 5168 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (269) .. (2314) <400> 231 cagccgccgg cggcgctagc acctcggagt cgggcggccg gagcagcgga gcgcagcgcg 60 gcgcagggaa cggcactggg ggtggggaga ccagcccggc cgagccgagg gccaccccct 120 ggtcctctgc cctcgcgccc cgctagggcc aggtgcacaa aaagctttaa acaagttaaa 180 atctaggcaa cagactccct gaagtgttga ctgcccaact taatcatgac tgtgattcaa 240 aaatgttaat aaataaacca aggtgtag atc atg ggg aat tca tat gct ggg 292 Ile Met Gly Asn Ser Tyr Ala Gly 1 5 caa ctg aaa tct gct cga ttt gag gaa gct ctc cac aac tcc ata gaa 340 Gln Leu Lys Ser Ala Arg Phe Glu Glu Ala Leu His Asn Ser Ile Glu 10 15 20 gcc tcc ctc aga tgt agt agt gtg gca cgg cca att ttt tcc cag 388 Ala Ser Leu Arg Cys Ser Ser Val Val Pro Arg Pro Ile Phe Ser Gln 25 30 35 40 cta tac ctg gac cct gac cag cat cct ttc tca tct gca gat gtc aaa 436 Leu Tyr Leu Asp Pro Asp Gln His Pro Phe Ser Ser Ala Asp Val Lys 45 50 55 ccc aag gtg gag gat ctg gac aaa gat ttg gta aac cgc tac act caa 484 Pro Lys Val Glu Asp Leu Asp Lys Asp Leu Val Asn Arg Tyr Thr Gln 60 65 70 aat gga agt ctg gat ttt tct aac aat cta aca gtt aat gaa atg gaa 532 Asn Gly Ser Leu Asp Phe Ser Asn Asn Leu Thr Val Asn Glu Met Glu 75 80 85 gat gat gaa gac gat gaa gaa atg tct gat tca aac agc cca cca att 580 Asp Asp Glu Asp Asp Glu Met Ser Asp Ser Asn Ser Pro Pro Ile 90 95 100 ccc tat tca caa aaa cct gcc cca gaa gga tct tgc act aca gat ggt 628 Pro Tyr Ser Gln Lys Pro Ala Pro Glu Gly Ser Cys Thr Thr Asp Gly 105 110 115 120 ttt tgt caa gca gga aag gat ttg cgt ttg gta tca ctg tgt atg gaa 676 Phe Cys Gln Ala Gly Lys Asp Leu Arg Leu Val Ser Leu Cys Met Glu 125 130 135 caa att gac atc cca gca gga ttc ctg ggg ggg ccc 724 Gln Ile Asp Ile Pro Ala Gly Phe Leu Leu Val Gly Ala Lys Ser Pro 140 145 150 aat ctg cct gaa cac atc cta gtt tgt gct gtg gac aag cga ttt cta 772 Asn Leu Pro Glu His Ile Leu Val Cys Ala Val Asp Lys Arg Phe Leu 155 160 165 cca gat gat cat gga aaa aat gca ctt tta ggg ttt tct gga aat tgt 820 Pro Asp Asp His Gly Lys Asn Ala Leu Leu Gly Phe Ser Gly Asn Cys 170 175 180 atc ggc tgt gga gaa aga gga ttt c ga tat ttc acg gaa ttt tcc aac 868 Ile Gly Cys Gly Glu Arg Gly Phe Arg Tyr Phe Thr Glu Phe Ser Asn 185 190 195 200 cac att aac ttg aag ctc acc act cag cca aag aag cag aag cac tta 916 His Ile Asnu Lys Leu Thr Thr Gln Pro Lys Lys Gln Lys His Leu 205 210 215 aag tac tac cta gtc aga agc tcc cag ggt gta ctg tct aaa gga cct 964 Lys Tyr Tyr Leu Val Arg Ser Ser Gln Gly Val Leu Ser Lys Gly Pro 220 225 230 ctt atc tgc tgg aaa gaa tgt aga agc cga caa tcc tct gct tct tgc 1012 Leu Ile Cys Trp Lys Glu Cys Arg Ser Arg Gln Ser Ser Ala Ser Cys 235 240 245 cac tct att aag cca agc tct tca gtg tcg tact acc cca gaa 1060 His Ser Ile Lys Pro Ser Ser Ser Val Ser Ser Thr Val Thr Pro Glu 250 255 260 aat ggg aca act aat gga tac aaa tca gga ttc act cag aca gat gct 1108 Asn Gly Thr Thr Asn Gly Tyr Lys Ser Gly Phe Thr Gln Thr Asp Ala 265 270 275 280 gct aat gga aac agt agc cat gga ggg aag ggc agt gca tcc agc tcc 1156 Ala Asn Gly Asn Ser Ser His Gly Gly Lys Gly Ser Ala Ser Ser Ser 285 290 290 295 act cca gcc cac aca ggg aat tac tct ttg tca cca cga cct agc tat 1204 Thr Pro Ala His Thr Gly Asn Tyr Ser Leu Ser Pro Arg Pro Ser Tyr 300 305 310 gca tca gga gat caa gct acc atg ttc att tct ggg cca cca aag aaa 1252 Ala Ser Gly Asp Gln Ala Thr Met Phe Ile Ser Gly Pro Pro Lys Lys 315 320 325 cga cac cgg gga tgg tat cct ggg tca cct ctc ccc caa cct ggc tta 1300 Arg His Arg Gly Trp Tyr Pro Gly Ser Pro Leu Pro Gln Pro Gly Leu 330 335 340 gtt gta cct gtc cct aca gtt cgc cct ctt tca aga acg gag ccc ctt 1348 Val Val Pro Val Pro Thr Val Arg Pro Leu Ser Arg Thr Glu Pro Leu 345 350 355 360 360 tta tct gcc cca gtt cca cag acc cca cta act gga att tta caa ccc 1396 Leu Ser Ala Pro Val Pro Gln Thr Pro Leu Thr Gly Ile Leu Gln Pro 365 370 375 agg ccc att cct gca ggg gaa act gta att gtt cct gaa aac ctg ctg 1444 Arg Pro Ile Pro Ala Gly Glu Thr Val Ile Val Pro Glu Asn Leu Leu 380 385 390 agt aac tca gga gtt aga cca gta att ctg ata ggc tat ggc act tta 1492 Ser Asn Ser Gly Val Arg Pro Val Ile Leu Ile Gly Tyr Gly Thr Leu 395 4 00 405 ccc tat ttc tat gga aat gtt ggt gac att gtt gtg agt cct ctg ctg 1540 Pro Tyr Phe Tyr Gly Asn Val Gly Asp Ile Val Val Ser Pro Leu Leu 410 415 420 gtg aat tgc tac aag att cca cag ttg gaaac gat ttg gaa aaa 1588 Val Asn Cys Tyr Lys Ile Pro Gln Leu Glu Asn Lys Asp Leu Glu Lys 425 430 435 435 440 tta ggg ttg acc ggc agc caa ttt ctg agc gtg gaa aac atg att ctt 1636 Leu Gly Gle Leu Thr Leu Ser Val Glu Asn Met Ile Leu 445 450 455 ctg acg ata cag tat ctt gtg cgg ctg ggt cct gat cag gta cct ctc 1684 Leu Thr Ile Gln Tyr Leu Val Arg Leu Gly Pro Asp Gln Val Pro Leu 460 465 470 agg gaaga ttt gag caa att atg ctg aaa gct atg caa gaa ttt act 1732 Arg Glu Glu Phe Glu Gln Ile Met Leu Lys Ala Met Gln Glu Phe Thr 475 480 485 ctg aga gaa aga gcc ctg cag ata ggt gct cag tgt gtc cgt Leu Arg Glu Arg Ala Leu Gln Ile Gly Ala Gln Cys Val Pro Val Ser 490 495 500 cca gga caa ctc ccc tgg ctt gct aga tta att gcc agc gta tct caa 1828 Pro Gly Gln Leu Pro Trp Leu Ala Arg Leu Ile Ala S er Val Ser Gln 505 510 515 520 gac ttg gtt cat gtg gtt gtg acc cag aac tct ttg gcg gag ggc att 1876 Asp Leu Val His Val Val Val Thr Gln Asn Ser Leu Ala Glu Gly Ile 525 530 535 tca gag acc tta agg act ctc agt gaa atg aga cac tat caa agg ctg 1924 Ser Glu Thr Leu Arg Thr Leu Ser Glu Met Arg His Tyr Gln Arg Leu 540 545 550 cca gat tat gtg gtg gta att tgt gca tcg aaa atc aga gga aat Tagaa 1972 Pro Val Val Val Ile Cys Ala Ser Lys Ile Arg Gly Asn Glu 555 560 565 ttt tgt gtg gta gtg tta ggt cag cac cag tcc cga gct ctg gca gag 2020 Phe Cys Val Val Val Leu Gly Gln His Gln Ser Arg Ala Leu Ala Glu 570 575 580 agc atg ctc acc aca agt gag ttt ttg aaa gaa att agt tat gag ctt 2068 Ser Met Leu Thr Thr Ser Glu Phe Leu Lys Glu Ile Ser Tyr Glu Leu 585 590 595 600 600 atc aca gga aag gtc agt ttc cat gca tca ttc aaa acc aca tca 2116 Ile Thr Gly Lys Val Ser Phe Leu Ala Ser His Phe Lys Thr Thr Ser 605 610 615 tta ggc gat gac cta gac aag ctg ctg gaa aaa atg caa caa aga aga 2164 Leu Gly Asp Asp Leu Asp Ly s Leu Leu Glu Lys Met Gln Gln Arg Arg 620 625 630 gga gac agt gtg gtt acc cct ttc gat gga gac ctt aat gaa tgt gtg 2212 Gly Asp Ser Val Val Thr Pro Phe Asp Gly Asp Leu Asn Glu Cys Val 635 640 645 tca ccc cag gag gct gct gct atg att ccc aca caa aac ctg ggt aat 2260 Ser Pro Gln Glu Ala Ala Ala Met Ile Pro Thr Gln Asn Leu Gly Asn 650 655 660 gtc atc tca gac caa gag gag gaa gtc agt cct tgg gac tgt 2308 Val Ile Ser Asp Gln Glu Glu Glu Val Ser Pro Trp Asp Arg His Cys 665 670 675 680 aaa aac taagtcattc taagggtttt gaggattctt caagtcacag accacaacag 2364 Lys Asn ccttttcctg attgtctaca tgataaacct ggttgaaatt aaaaatgctt tcccatgtgg 2424 cctggatcaa aggctttgtt cctagtaaaa gtcttctgga atgaaaatca aagtcaaaga 2484 ctttatctta agcactctct cttttttctc tgaaagattc caggacattg gctcattttc 2544 cttagctcca ccagctgtgc ccagaggact tcaaaaaacc gtctgaaaga gtcagactac 2604 aggcagtgca gggtccccag ctcctgctcc ttcacttcct gtctgactcg gtctgactgcat tgaccagcat gcattgcagcat gcattgcagcat gcattgcagcat gcatcgcat gagcgatgcagcat gcat aa caagcttcag gggctcaaag tgggagtgtc agggatgagg agtctgatca 2784 ttaagactgg attcatttgg gttcagattt cttccccaat tcactgattg acaggaatga 2844 cataggacag gacagaaaaa agaacaggag aaaggatagt tgggagacag acccatataa 2904 gctgctgctg acagccactt ggcccccact tgataggaat gtatcattta tatattagga 2964 ttgtctcagg caataaaagt agcatggctt ggcagtcagc tctgttgtta aaacaaatgc 3024 aaatataggc agtaaaatgt tttgacttct caatggtatt tggtaataaa gtgatgatcc 3084 ggatgatcta aaatgtgttt atattaactg ttttgaattg ttaacacatt tagaatttaa 3144 acattctgag aggacttaca gattccggag tacattcttg gttccctgtt taaaaacctt 3204 gtttaaagat gtttttgaaa taacagccta actgtattaa aagacagata tattttgatt 3264 agtagtctgt ggtacaaaga ctatttgggc ttctatttaa agttgcaggt ttgggctttt 3324 ccagtggatt ctctcaacta ctagggagac catccatcta aatctccact tgctgtcagt 3384 atccatggta actgggatat gttgacggct gtctttgcct cggctgcatt tgattttaga 3444 aaacattaat tagcacaggt taattaggcc ctgttgcagt taaactgcca catgtgttcc 3504 tgataataac cagtgcttta aagaagcatt ggatgttgcc tgctcacgtg tttagctgac 3564 taaacttctt tc attgtgtg tgtggatgtg catgcacgta taagaaagat tgatcgcttg 3624 attatacttg caataaaaag ctactgacct gcttagagta tctgggaaat gtttttgtaa 3684 tatgtcacct gctgagtggc cagctggcta tgtcatgagt caggtgtctt cagatagtcc 3744 aggcatcagc actggagctg gccacaacca cctagacctg ctaggtcaca gcactggcaa 3804 agtggagtcc agtgggaaga aaggtgaagg tcgtgtctcc atgacccacg ttatgtagtg 3864 actggggagg gaatttccga ccatgttgca actgacttgc taaagaggaa atatttactg 3924 tagtgccttc cagaaaagct caggggaact cagcatcatg atcattatgg catcccctct 3984 ttccttgaac tgggtcgggg ctggagaact ggcctgtgct gatatttcta aagaaaactg 4044 gaaatgctac cctttccagg gatgagtctt ggctccagct gcgacagtgt agtcggtctc 4104 ctccacttct gggttgggat aggggtgttg aattaggcat ttgtgagata atcaatcaat 4164 ttttaaataa tacatttgca aaactgcagc atccactcct gagcacatcc tctcatccac 4224 gtttcaggga aaataggcaa atctattaaa actcaataga gagtgcaaat agcaggtgag 4284 aattcgtagt gagagtgtat tacattaccg tctgtgtggt atgtgtcctc atagagattc 4344 acagtggcca ttagggaagt aaattaacct tgttcttatg acttctcttt aaattttaga 4404 tttagataat gaaacctt cc acatttatca accgcagcta acagttgcca gaaaactctt 4464 atcccaggtg tgtgctatag cggacagtgg cagccagagc ctggacctcg gtcacttcag 4524 caaagtagac ttcatcatca ttgttcccag atcggaggtg ttggttcagc aaactcttca 4584 gcggattcga caatcaggta agagtgaact ttcaaagagg agcccaccta gatccagctt 4644 cagatcccct ctgcctcttt cttttgctta atccaaacgt ctagaggatg cttaaaacct 4704 tcttcagtaa taaaaatcat aaaagcactt tgttattttg ggtttatctg aagttttccc 4764 tcaaagtact ctgtcctttt tccctcaagg tcaagggtaa attgttgtgc atgtttgcca 4824 ggtatcatta agttcatgat gtaatctgtg ggactagaat ctggtcattt atggatgaag 4884 agaaattttc tcaaggcgag gatggccctg catgggttga tggcgtctgt gccacctgaa 4944 ctcctcccac ctgcaggcct catttgcata ggtggattct tggccatcta gcacattaac 5004 agcacgtctg ggacctggaa accagaacac catcccccat gtcagcaatg acgttcttta 5064 agaaaaaaag gttagcgtta tttctaataa ctttaagtgt aaagaaaaaa aaatgttttt 5124 cccagaaaat gtgaaaaggt agagagcaaa aattttacaa gtct 5168 <210> 232 <211> 3839 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2) .. (2455) <400> 232 g gcg aag agg cag gaa gac aag acc atg tcg aag ggc ccc ggg ccc ggc 49 Ala Lys Arg Gln Glu Asp Lys Thr Met Ser Lys Gly Pro Gly Pro Gly 1 5 10 15 ggc tcc gca gct tcc tcg gcg ccc ccg gcc gct acc gct cag gtg ctg 97 Gly Ser Ala Ala Ser Ser Ala Pro Pro Ala Ala Thr Ala Gln Val Leu 20 25 30 cag gca cag ccc gag aaa ccg cag cac tac acg tac ctg aaa gaa ttc 145 Gln Ala Gln Pro Glu Lys Pro Gln His Tyr Thr Tyr Leu Lys Glu Phe 35 40 45 cgc aca gag cag tgc cca ctc ttt gtg caa cac aaa tgc acg cag cat 193 Arg Thr Glu Gln Cys Pro Leu Phe Val Gln His Lys Cys Thr Gln His 50 55 60 cgg ccc tac acc tgc ttc cac tgg cac ttc gtg aac cag cgg cgc cgc 241 Arg Pro Tyr Thr Cys Phe His Trp His Phe Val Asn Gln Arg Arg Arg 65 70 75 80 cgg tcc atc cgc cgt cgg gac ggc acc ttc aat tac cct gac gtc 289 Arg Ser Ile Arg Arg Arg Asp Gly Thr Phe Asn Tyr Ser Pro Asp Val 85 90 95 tac tgc acc aag tac gac gag gct aca ggc ctc tgc ccg gag ggc gac 337 Tyr Cys Thr Lys Tyr Asp Glu Ala Thrly Leu Cys Pro Glu Gly Asp 100 105 110 gag tgc cca ttc ctg cac aga acc aca ggg gac act gag cgc agg tac 385 Glu Cys Pro Phe Leu His Arg Thr Thr Gly Asp Thr Glu Arg Arg Tyr 115 120 125 cac ctt cgt tac tac aaa act gga atc tgc atc cac gag aca gac tcg 433 His Leu Arg Tyr Tyr Lys Thr Gly Ile Cys Ile His Glu Thr Asp Ser 130 135 140 aaa ggc aac tgc acc aaa aac ggc ctg cac tgc gct ttt gcc cac ggg 481 Lys Gly Asn Cys Thr Lys Asn Gly Leu His Cys Ala Phe Ala His Gly 145 150 155 160 ccc cat gac ctc cgc tcc cct gtc tac gac atc agg gag ctt cag gcc 529 Pro His Asp Leu Arg Ser Pro Val Tyr Asp Ile Arg Glu Leu Gln Ala 165 170 175 atg gag gcc ttg cag aat ggc cag acc acg gta gag ggg agc ata gag 577 Met Glu Ala Leu Gln Asn Gly Gln Thr Thr Val Glu Gly Ser Ile Glu 180 185 190 ggc cag tcg gct ggg gct gcg agc cat gcc atg ata gaa aag atc ctc 625 Gln Ser Ala Gly Ala Ala Ser His Ala Met Ile Glu Lys Ile Leu 195 200 205 agc gag gag cct cgg tgg caa gag act gct tat gtg ctg ggg aac tat 673 Ser Glu Glu Pro Arg Trp Gln Glu Thr Ala Tyr Val Leu Gly AsnTyr 210 215 220 aag acg gag cct tgc aag aag ccc ccg cgg ctg tgc cgc caa ggc tat 721 Lys Thr Glu Pro Cys Lys Lys Pro Pro Arg Leu Cys Arg Gln Gly Tyr 225 230 235 240 gcc tgt ccc tac tac cac aag ac ag gac cgg cgg cgg agc ccc cgg 769 Ala Cys Pro Tyr Tyr His Asn Ser Lys Asp Arg Arg Arg Ser Pro Arg 245 250 255 aag cac aaa tac agg tcg tct cca tgt cca aac gtc aag cac ggg gat 817 Lys His Lys Tyr Arg Ser Ser Pro Cys Pro Asn Val Lys His Gly Asp 260 265 270 gag tgg gga gac cct ggc aag tgt gag aac gga gac gcc tgc cag tac 865 Glu Trp Gly Asp Pro Gly Lys Cys Glu Asn Gly Asp Ala Cys Gln Tyr 275 280 285 tgc cac acc cgc acc gag cag cag ttc cac ccc gag atc tac aag tcc 913 Cys His Thr Arg Thr Glu Gln Gln Phe His Pro Glu Ile Tyr Lys Ser 290 295 300 acc aag tgc aac gac atg cag cag tcg ggc agc tgt ccc cga gga ccc 961 Thr Lys Cys Asn Asp Met Gln Gln Ser Gly Ser Cys Pro Arg Gly Pro 305 310 315 320 ttc tgc gcc ttt gcc cac gta gaa cag cca ccc ctg agt gac gac ctg 1009 Phe Cys Ala Phe Ala His Val Glu Gln Pro Pr o Leu Ser Asp Asp Leu 325 330 335 cag cct tcc tca gct gtg tcc agc ccc acc cag ccg ggt cct gtc ctg 1057 Gln Pro Ser Ser Ala Val Ser Ser Pro Thr Gln Pro Gly Pro Val Leu 340 345 350 350 tac atg cca tct gcc gcc gga gac tcg gtg cct gtg agc ccc tcc agc 1105 Tyr Met Pro Ser Ala Ala Gly Asp Ser Val Pro Val Ser Pro Ser Ser 355 360 365 ccg cat gcc cct gac ctc agt gcc ctc ctc tgt aga aac agc agc cta 1153 Pro His Ala Pro Asp Leu Ser Ala Leu Leu Cys Arg Asn Ser Ser Leu 370 375 380 ggc agc ccg tct aac ctc tgc ggc tcc cca ccg ggc tcc atc agg aag 1201 Gly Ser Pro Ser Asn Leu Cys Gly Ser Pro Pro Gly Ser Ile Arg Lys 385 390 395 400 ccc cca aac ctg gag ggc atc gtc ttc cct ggg gag tct ggc ctg gcc 1249 Pro Pro Asn Leu Glu Gly Ile Val Phe Pro Gly Glu Ser Gly Leu Ala 405 410 415 cct ggc agc tat aag aag gct ccc gag agg gaa gac cag gtg 1297 Pro Gly Ser Tyr Lys Lys Ala Pro Gly Phe Glu Arg Glu Asp Gln Val 420 425 430 gga gcc gag tac ctg aaa aat ttc aaa tgc cag gcc aaa tta aaa ccc 1345 Gly Ala Glu Tyr Leu Lys Asn Phe Lys Cys Gln Ala Lys Leu Lys Pro 435 440 445 cac tca tta gag ccc agg agt caa gag cag cct ctg ctt cag ccc aaa 1393 His Ser Leu Glu Pro Arg Ser Gln Glu Gln Pro Leu Leu Gln Pro Lys 450 455 460 cag gac atg ctg ggc atc ctc ccc gca ggc agc ccc ctg acc tca agc 1441 Gln Asp Met Leu Gly Ile Leu Pro Ala Gly Ser Pro Leu Thr Ser Ser 465 470 475 475 480 atc tct tct agt atc acc tcc agc ctg gca gct ccc agc cca 1489 Ile Ser Ser Ser Ile Thr Ser Ser Leu Ala Ala Thr Pro Pro Ser Pro 485 490 495 gtg ggc acc agc agc gtc ccc ggc atg aat gca aac gct ctg ccc ttc 1537 Val Gly Thr Ser Ser Val Pro Gly Met Asn Ala Asn Ala Leu Pro Phe 500 505 510 tac ccc acc agc gac acg gta gag tca gtc ata gag tct gct ttg gat 1585 Tyr Pro Thr Ser Asp Thr Val Glu Ser Val Ile Glu Ser Ala Leu Asp 515 520 525 gac ctg gac ctg aat gag ttt ggc gtg gcc gcc ctg gag aag act ttc 1633 Asp Leu Asp Leu Asn Glu Phe Gly Val Ala Ala Leu Glu Lys Thr Phe 530 535 540 gat aac agc aca gtg ccc cac cca gga agc atc acc atc ggc ggc ag Asn Ser Thr Val Pro His Pro Gly Ser Ile Thr Ile Gly Gly Ser 545 550 555 560 ttg ctg cag agc tct gcg ccc gtg aac atc ccc ggc tcc ttg ggc agc 1729 Leu Leu Gln Ser Ser Ala Pro Val Asn Ile Pro Gly Ser Leu Gly Ser 565 570 575 tct gcc tcc ttc cac tca gca tcc ccg tcc cct ccc gtc agc ctc tcc 1777 Ser Ala Ser Phe His Ser Ala Ser Pro Ser Pro Pro Val Ser Leu Ser 580 585 590 tcg cat ttc ctg cag cag ccc cag ggc cac ctg agt cag tcg gaa aac 1825 Ser His Phe Leu Gln Gln Pro Gln Gly His Leu Ser Gln Ser Glu Asn 595 600 605 aca ttt ttg gga acc tca gca tca cat gga tct ttg ggt ctg aac ggg 1873 Thr Phe Leu Gly Thr Ser Ala Ser His Gly Ser Leu Gly Leu Asn Gly 610 615 620 atg aac agc agc atc tgg gag cat ttt gcc tct gga agc ttc tcc ccg 1921 Met Asn Ser Ser Ile Trp Glu His Phe Ala Ser Gly Ser Phe Ser Pro 625 630 635 640 ggc act tcc ccc gct ttc cta tca ggg cca ggg gct gcc gag ctg gcc 1969 Gly Thr Ser Pro Ala Phe Leu Ser Gly Pro Gly Ala Ala Glu Leu Ala 645 650 655 cga ctt cgg caa gag ctg gat gaa gcc aac agc acc at c aag cag tgg 2017 Arg Leu Arg Gln Glu Leu Asp Glu Ala Asn Ser Thr Ile Lys Gln Trp 660 665 670 gag gag tcc tgg aag cag gcc aag cag gct tgt gat gcc tgg aag aaa 2065 Glu Glu Ser Trp Lys Gln Ala Lys Gln Ala Cys Asp Ala Trp Lys Lys 675 680 685 gag gcg gag gag gct ggt gag cgg gcc agt gcg gcg ggc gcc gag tgc 2113 Glu Ala Glu Glu Ala Gly Glu Arg Ala Ser Ala Ala Gly Ala Glu Cys 690 695 gag gg gag cag cgg gat gca ctg gag gtg cag gtg aag aag 2161 Glu Leu Ala Arg Glu Gln Arg Asp Ala Leu Glu Val Gln Val Lys Lys 705 710 715 715 720 ctc cag gag gag ctg gag cgg cta cac gcg ggg cct gcc ccc Leu Gln Glu Glu Leu Glu Arg Leu His Ala Gly Pro Glu Pro Gln Ala 725 730 735 ctg ccc gcc ttc tcc gac ctg gag gcg ctc tca ctc tcc acc ctc tac 2257 Leu Pro Ala Phe Ser Asp Leu Glu Ala Leu Ser Le Thrhr Leu Tyr 740 745 750 tcc ctc cag aaa caa ctg cgg gcc cac ctg gaa caa gtg gac aag gcc 2305 Ser Leu Gln Lys Gln Leu Arg Ala His Leu Glu Gln Val Asp Lys Ala 755 760 765 gtg ttc cg atg ag tag cg a tgc ctt aag tgt cag gaa cag aag 2353 Val Phe His Met Gln Ser Val Lys Cys Leu Lys Cys Gln Glu Gln Lys 770 775 780 cgg gca gtg ctg ccg tgc caa cac gct gcg ctg tgt gag ctc tgc Act Val 240 Arg Pro Cys Gln His Ala Ala Leu Cys Glu Leu Cys Ala 785 790 795 800 gag ggc agc gag tgc ccc atc tgc cag cct ggc cgg gcc cac acc ctc 2449 Glu Gly Ser Glu Cys Pro Ile Cys Gln Pro Gly Arg Ala His Thr Leu 805 810 815 cag tcg tgaccctgca ggcctggccc agcctggccc agatcttctc acctaggact 2505 Gln Ser ttttaaagta tatatatata tatgaatata tatatatatg tgtatgtatg tatgtatatg 2565 tatatgatta tgtatatgta tacatttccg tatgtatgta tatgtataca tttccgtatg 2625 tgtgcaggta tgcgtggtgg tgtggacagt gtctgtgtgt atatctgtac atagatatag 2685 acacacactt taaaagactt accaagcact ttttaaaaga agaaactatt ttgcagtcct 2745 cccctaccca ctccctgccc ttcccactgc agagatgaca tcccctcttc tcccactggc 2805 cttttggcag agaatctggt tctgtctctt ttttaatgta ggaactaact atttttaact 2865 tcttcctggg gcctgagcag ggaagggtgg gactggaagg cactaagggg aagggagaag 2925 ccctcagggc aggccct gct ccccctacct ccttgccagg gcaagggtgg agtgtggaag 2985 acgtgggtcc cccagagcag gcctggcccc cagctgtgag ggcctcaggg aggcccgagg 3045 gggagtgctg ggggtctcag ctggcttagc tcctaagttt accaaatgtt aatttagtct 3105 tggggagaac agcaagggct ggaggccagt gctgcagggc cagccccact cctgacacct 3165 gggcccttga agctccttga ggggcaaggc ccaggagttc cagccctcag gttcctgagg 3225 gtccaccctc agtccttccc cccgccgccc ctccccggac tccccacaag agcctccctg 3285 gccccagggc cgcctaccag gctggtactc attctatgac caccgccccc aaccagctgc 3345 ccccagctct ccctgccccc tcccctctct ggcagctagc agggcaattg gcggggagga 3405 gtgcggactg aggactgagg accaaggggg cccaggccct gccctcctac ccggaggggc 3465 tccgtttgca ttccttggtg ctctctgagt gcagctggtg tcccgccctg ttctgggcgg 3525 acgcctgtgt gcgtgtgtgt gtgcctgtcc agtgtatatt gtgtcttagc ttccatttta 3585 aaaattgttc tgtacagaga gagatgcagc aggggcggga gggcagagtg ggcggagggg 3645 agcagccgca cccccagcac cgggtgtctg cggtaggaac aagagggctg agagggtctg 3705 gtcctggccc aggctccccc ttgggctcag cacgaaaggg ctttcaatga attaagtgaa 3765 aactttttcc ttttttacaa a aatgcaaaa atcaacaaag ctccaaacct attggaaata 3825 aaatatgaac ttgc 3839 <210> 233 <211> 4088 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (32) .. (1813) <400> 233 agcgggggca tcgccgcccg cgcccctcta a gtg ccg ggc cgc aag ctc cac 52 Val Pro Gly Arg Lys Leu His 1 5 cgc agc cgc ctg caa gca gcg gcg cct cgg ccc tcg Acc tgg Alcg Agg Acg Acg Acg Agg Acg Acg Acg Agg Acg Acg Acg Agg Acg Acg Acg Agg Acg Agg Acg Agla Pro Arg Pro Ser Thr Cys Ala Gln 10 15 20 agc ctg tgc tgg agc cgt cct ccc gcg gcg ggg acc ggg acc ggg gac 148 Ser Leu Cys Trp Ser Arg Pro Pro Ala Ala Gly Thr Gly Thr Gly Asp 25 30 35 cca agc caa tcg aaa gct cca acc atg gcc atg ggg ctc ttc cgc gtg 196 Pro Ser Gln Ser Lys Ala Pro Thr Met Ala Met Gly Leu Phe Arg Val 40 45 50 55 tgt ctg gtg gtg gtg acg gcc atc atc aac cac ccg ctg ccg 244 Cys Leu Val Val Val Thr Ala Ile Ile Asn His Pro Leu Leu Phe Pro 60 65 70 cgg gag aac gcc aca gtc ccc gag aac gag gag gag atc atc cgc aag 292 Arg Glu Asn Ala Thr Val Pro Glu Asn Glu Glu Glu Ile Ile Arg Lys 75 80 85 atg cag gcg cac cag gag aag ctg cag ctg gag cag ttg cgc ctg gag 340 Met Gln Ala His Gln Glu Lys Leu Gln Leu Glu Gln Leu Arg Leu Glu 90 95 100 gag gag gtg gc cgg gg gaa aag g ag gca ctg gag cag gtg 388 Glu Glu Val Ala Arg Leu Ala Ala Glu Lys Glu Ala Leu Glu Gln Val 105 110 115 gcg gag gag ggc agg cag cag aac gag aca cgc gtg gcc tgg gac ctc 436 Ala Glu Glu Gly Arg Asn Glu Thr Arg Val Ala Trp Asp Leu 120 125 130 135 tgg agc acc ctc tgc atg atc ctc ttc ctg atg atc gag gtg tgg cgg 484 Trp Ser Thr Leu Cys Met Ile Leu Phe Leu Met Ile Glu Val Trp Arg 140 145 150 cag gac cac cag gag ggg ccc tca cct gag tgc ctg ggc ggt gag gag 532 Gln Asp His Gln Glu Gly Pro Ser Pro Glu Cys Leu Gly Gly Glu Glu 155 160 165 gat gag ctg cct ggg ctg ggg ggc gcc ccc ttg cag acc ctg 580 Asp Glu Leu Pro Gly Leu Gly Gly Ala Pro Leu Gln Gly Leu Thr Leu 170 175 180 ccc aac aag gcc acg ctt ggc cac ttt tat gag cgc tgc atc cgg ggg 628 Pro Asn Lys Ala Thr Leu Gly His Phe Tyr Glu Arg Cys Ile Arg Gly 185 190 195 gcc acg gcc gat gca gcc cgt acc cgg gag ttc ctg gaa ggc ttc gtg 676 Ala Thr Ala Asp Ala Ala Arg Thr Arg Glu Phe Leu Glu Gly Phe Val 200 205 210 215 gat gac ttg ccg ga c tg agg agc ctc tgc aac cgg gac acc gac 724 Asp Asp Leu Leu Glu Ala Leu Arg Ser Leu Cys Asn Arg Asp Thr Asp 220 225 230 atg gag gtg gag gac ttc att ggc gtg gac agc atg tac gag aac tgg 772 Glu Asp Phe Ile Gly Val Asp Ser Met Tyr Glu Asn Trp 235 240 245 cag gtg gac agg cca ctg ctg tgc cac ctt ttc gtg ccc ttc aca ccc 820 Gln Val Asp Arg Pro Leu Leu Cys His Leu Phe Val Pro Phe Thr 250 255 260 ccc gag ccc tac cgc ttc cac cca gag ctc tgg tgc tcc ggc cgc tca 868 Pro Glu Pro Tyr Arg Phe His Pro Glu Leu Trp Cys Ser Gly Arg Ser 265 270 275 gtg ccc ctg gat cgc cag ggc tac ggc ca gtg gtc cgc gcc 916 Val Pro Leu Asp Arg Gln Gly Tyr Gly Gln Ile Lys Val Val Arg Ala 280 285 290 295 gat ggg gac aca ttg agc tgc atc tgc ggc aag acc aag ctc ggg gaa 964 Asp Gly Asp Leu Cys Gly Lys Thr Lys Leu Gly Glu 300 305 310 gac atg ctg tgt ctc ctg cac ggc agg aac agc atg gcg cct ccc tgc 1012 Asp Met Leu Cys Leu Leu His Gly Arg Asn Ser Met Ala Pro Pro Cys 315 320 325 ggg g gag aac ctg ctg tgt gcc aca gat tcc ctg tac ctg gac 1060 Gly Asp Met Glu Asn Leu Leu Cys Ala Thr Asp Ser Leu Tyr Leu Asp 330 335 340 acg atg cag gtc atg aag tgg ttc cag acg gcc ccc acc aga Thr Met Gln Val Met Lys Trp Phe Gln Thr Ala Leu Thr Arg Ala Trp 345 350 355 aag ggc atc gcc cac aag tac gag ttc gac ctg gcc ttt ggc cag ctg 1156 Lys Gly Ile Ala His Lys Tyr Glu Phe Asp Leu Ala Ghe Gln Leu 360 365 370 375 gac agc ccg ggg tcc ctg aag atc aag ttc cgt tca ggg aag ttc atg 1204 Asp Ser Pro Gly Ser Leu Lys Ile Lys Phe Arg Ser Gly Lys Phe Met 380 385 390 ccc ttc aac gtg att cct cag tgt gat gac tcg gac ctg tac 1252 Pro Phe Asn Leu Ile Pro Val Ile Gln Cys Asp Asp Ser Asp Leu Tyr 395 400 405 ttt gtc tcc cac ctt ccc agg gag ccc tct gag ggc acc cca gcc tcc 1300 Phe Val Ser His Leu Pro Arg Glu Pro Ser Glu Gly Thr Pro Ala Ser 410 415 420 agc aca gac tgg ctc ctg tcc ttt gct gtc tat gag cga cac ttc ctc 1348 Ser Thr Asp Trp Leu Leu Ser Phe Ala Val Tyr Glu Arg His Phe Leu 425 430 435 agg acg aca cta aag gca ctg ccc gag ggc gcc tgc cac ctc agc tgc 1396 Arg Thr Thr Leu Lys Ala Leu Pro Glu Gly Ala Cys His Leu Ser Cys 440 445 450 455 ctg cag ata gca tcc ttc ccg gc agc cgc ctg acc ggt 1444 Leu Gln Ile Ala Ser Phe Leu Leu Ser Lys Gln Ser Arg Leu Thr Gly 460 465 470 ccc agc ggg ctc agc agc tac cac ctg aag acg gcc cta ctg cac ctc 1492 Pro Ser Gly Leu Ser Ser Leu Lys Thr Ala Leu Leu His Leu 475 480 485 cta ctc ctc cgg cag gcc gcc gac tgg aag gcg ggg cag ctg gac gct 1540 Leu Leu Leu Arg Gln Ala Ala Asp Trp Lys Ala Gly Gln Leu Asp Ala 490 495 500cgt gag ttg ctg tgc ttc ctg gag aag agc ttg ctc cag aag 1588 Arg Leu His Glu Leu Leu Cys Phe Leu Glu Lys Ser Leu Leu Gln Lys 505 510 515 aag ctc cac cac ttc ttc atc ggc agcc gc agc gc ag cg gag agc gc ag gc ag gc ag cg gag ag cg c Lys Leu His His Phe Phe Ile Gly Asn Arg Lys Val Pro Glu Ala Met 520 525 530 535 gga ctc cct gag gcc gtg ctc agg gcc gag ccc ctc aac ctc ttc cgg 1684 Gly Leu Pro Glu Ala Val Leu Arg Ala Glu Pro Leu Asn Leu Phe Arg 540 545 550 ccc ttc gtc ctg cag cga agc ctt tac cgt aag aca ctg gac tcc ttc 1732 Pro Phe Val Leu Gln Arg Ser Leu Tyr Arg Lys Thr Leu Asp Ser Phe 555 560 565 tat gag atg at ag at ag c gcc cca gcg ctc att agc gag tat tcc cta 1780 Tyr Glu Met Leu Lys Asn Ala Pro Ala Leu Ile Ser Glu Tyr Ser Leu 570 575 580 cat gtc ccc tca gac cag cct acc cca aaa agc tgacgtcttt tacagaat Asp G1 Pro Pro Thr Pro Lys Ser 585 590 gggatcctcg agctaagatg agggcatccc tcacgttcac acccctggtg gcatctgcca 1893 gccctgttct ggggacaagg cgggctttcg tgggagccgt gctcagcctg ccaggaagcc 1953 aagccctaca gtgcagagga aacagaattt caacgggaag ctggtttgct tcataccatt 2013 gggatctgct ggtaaagctg ttatttgggt ttagggactg atcccttgca gtttacttct 2073 ggatcaccat gaatggccaa gatggtggca gaacacgctg tggaccctga gttagagaca 2133 atgcaaatgt tggattgggt gtaattcttt ttgaatccca gatccagtct gtacttgaat 2193 atgagcagag gatctacaag aatgctgaca gggaaccgtg ttaagaccca gcacccctat 2253 tcccaggagc ttctggcctg accatctgca gccaaagcac taacagggac aga tatggga 2313 atgtccacct ttgatccgca tcctgcacaa tagtggtccc accatggctg ccactttttt 2373 atactatttg gagaaaagac cttgtataaa ttcgaggccc gagtgactaa cgtctctgtc 2433 acacggaaat gggtacttgg tggcatagag aaacacaatt agccactttt tcagctacac 2493 ttctcactca gctgcaccct acacttctca ctcaggtgca cccccttctg ctgtcctttc 2553 cccaacgtac tgggtcccga gcgtggtggg tatttgccac actgggtgcc agctcagcag 2613 ccccccacct ctctttattc tctccaaagc tggtctttct gactatcatt gtggtagggg 2673 gaggacagat gctaaaggtg gaagctgacc tggaaaaaga gacacacggg gtgactgtgg 2733 caaaggacag ctggaaaaga aactctatca cttcttcatt ggcaaccaca aggcacctga 2793 ggccatggca ctcccagagg ctgtgcgcag agccaagcct ctcaacctct tctggccctg 2853 cgtcctgcag cgaagtctct gctgtaagac agtagactcc ttcgatgagg tgctcaaaaa 2913 tgctacccgg ggtggtggtg tctggcttgc agtctggccc agttcagaga aagttgcaga 2973 gatcaggggc caaggatgtc atagccccag gttgtcctca gggtcccaat cctagggcag 3033 ggtgtgcatg gaagcaagaa ctatggaaac ctagctccag tctgcaggct ctgagcccct 3093 agttcctcac tccagcgggg ctccctcact gcacagaacc caccccttct gtgtgggc ac 3153 tgctgaccac acagatgacc cagacccaaa gagcctggca gaagctctgt ggttggagct 3213 gggctccgtc tccaggtctg gttcaggggg atcaggaagg ctcttttcca cctgtggctt 3273 cactggccct ttgagatttc ctatctcacc gttacttcag ttacccttgc agggggccag 3333 ggagtcaaga atataccgtg ttcctccagg gtttaagccg gccatgcctt cccgagagca 3393 taaccaactt gacaggggtg cccagttacc ccacaaactg aaggaaggag atccttcccc 3453 cgtccccagg agtgctctca accagcctca gaaagcttga gaagatggac cctttgccca 3513 ccagggttaa ttcctggtgg ggcagctcgg ctgtgatcag ggcaaccaaa cctataggaa 3573 gccttccagt gtgagctgga attagactga acatgtgctt gggcctgcct ctccctagac 3633 gcagttgcgg ggcactccag ggaatgaacc agctcaagtg tgtccctaac agcagcctgg 3693 agctaccccc aatccctcac agcctgaccc tcctcattcc atcagatgca tttgtagaat 3753 cggggcaaat ttccttattt atttatggcc catgcctttc cccctcttca tcctgatccc 3813 gttttgcttt gaagagaccc cagtaaccaa aaaacagcct ccagaagcca aaaccatgcc 3873 tggatctccc atagcttctc ctttgcttcc aggagaaagt tcactgaaaa aaaaatatct 3933 tctggcttct tgtgtgtaca gagacaacag aactcggtgg ggaaacggga atcttttctg 39 93 caccaaagct gcttctaaag cagaaagcag tggggctctt ggtgtttcat gctgccttat 4053 ttatattaaa ggaagaatta aatcttgcaa ggagt 4088 <210> 234 <211> 4370 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3) .. (1475) <400> 234 ac aag cca tta aac agt gag atc aga gag ctg ttg aaa cta ctg tca 47 Lys Pro Leu Asn Ser Glu Ile Arg Glu Leu Leu Lys Leu Leu Ser 1 5 10 15 aaa ccc aat gtg aag gct ttg ctc tct gta cat gat act gtg gct cag 95 Lys Pro Asn Val Lys Ala Leu Leu Ser Val His Asp Thr Val Ala Gln 20 25 30 aag aat tac gac cca gtg ttg cct cct atg cct gaa gat att gac gat 143 Lys Asn Tyr Asp Pro Val Leu Pro Pro Met Pro Glu Asp Ile Asp Asp 35 40 45 gag gaa gac tca gta aaa ata atc cgt ctg gtc aaa aat aga gaa cca 191 Glu Glu Asp Ser Val Lys Ile Ile Arg Leu Val Lys Asn Arg Glu Pro 50 55 60 ctg gga gct acc att aag aag gat gaa cag acc ggg gcg atc att gtg 239 Leu Gly Ala Thr Ile Lys Lys Asp Glu Gln Thr Gly Ala Ile Ile Val 65 70 75 gcc aga atc atg aga gga gga gct gca gat aga agt ggt ctt att cat 287 Ala Arg Ile Met Arg Gly Gly Ala Ala Asp Arg Ser Gly Leu Ile His 80 85 90 95 gtt ggt gat gaa ctt agg gaa gtc aac ggg ata cca gtg gag gat aaa 335 Val Gly Asp Glu Leu Arg Glu Val Asn Gly Ile Pro Val Glu Asp Lys 100 105 110 agg cct gag gaa ata ata cag att ttg gct cag tct cag gga gca att 383 Arg Pro Glu Glu Ile Ile Gln Ile Leu Ala Gln Ser Gln Gly Ala Ile 115 120 125 aca ttt aag att ata ccc ggc agc aaa gag gag aca cca tca gaa 431 Thr Phe Lys Ile Ile Pro Gly Ser Lys Glu Glu Thr Pro Ser Lys Glu 130 135 140 ggc aag atg ttt atc aaa gcc ctc ttt gac tat aat cct aat gag gat 479 Gly Lys Met Phe Ile Lys Ala Leu Phe Asp Tyr Asn Pro Asn Glu Asp 145 150 155 aag gca att cca tgt aag gaa gct ggg ctt tct ttc aaa aag gga gat 527 Lys Ala Ile Pro Cys Lys Glu Ala Gly Leu Ser Phe Lys Lys Gly Asp 160 165 170 175 att ctt cag att atg ac caa gat gat gca act tgg tgg caa gcg aaa 575 Ile Leu Gln Ile Met Ser Gln Asp Asp Ala Thr Trp Trp Gln Ala Lys 180 185 190 cac gaa gct gat gcc aac ccc agg gca ggc ttg atc ccc tca aag cat 623 His Glu Ala Asp Ala Asn Pro Arg Ala Gly Leu Ile Pro Ser Lys His 195 200 205 ttc cag gaa agg aga ttg gct ttg aga cga cca gaa ata ttg gtt cag 671 Phe Gln Glu Arg Arg Leu Ala Leu Arg Arg Pro Glu Ile Leu Val Gln 0 215 220 ccc ctg aaa gtt tcc aac agg aaa tca tct ggt ttt aga aga agt ttt 719 Pro Leu Lys Val Ser Asn Arg Lys Ser Ser Gly Phe Arg Arg Ser Phe 225 230 235 cgt ctt agt aga aaa gat aag aaa aca aat aaa tcc atg tat gaa tgc 767 Arg Leu Ser Arg Lys Asp Lys Lys Thr Asn Lys Ser Met Tyr Glu Cys 240 245 250 255 aag aag agt gat cag tac gac aca gct gac gta ccc aca tac gaa gaa 815 Lys Lys Ser Asp Gln Tyr Asp Thr Ala Asp Val Pro Thr Tyr Glu Glu 260 265 270 gtg aca ccg tat cgg cga caa act aat gaa aaa tac aga ctc gtt gtc 863 Val Thr Pro Tyr Arg Arg Gln Thr Asn Glu Lys Tyr Arg Leu Val Val 275 280 280 285 ttg gtt ggt ccc gtg gga gta ggg ctg aat gaa ctg aaa cga aag ctg 911 Leu Val Gly Pro Val Gly Val Gly Leu Asn Glu Leu Lys Arg Lys Leu 290 295 300 ctg atc agt gac acc cag cac tat ggc gtg aca accg ccc 959 Leu Ile Ser Asp Thr Gln His Tyr Gly Val Thr Val Pro His Thr Thr 305 310 315 aga gca aga aga agc cag gag agt gat ggt gtt gaa tac att ttc att 1007 Arg Ala Arg Arg Ser Gln Glu Ser Asp Gly Val Glu TyrIle Phe Ile 320 325 330 335 tcc aag cat ttg ttt gag aca gat gta caa aat aac aag ttt att gaa 1055 Ser Lys His Leu Phe Glu Thr Asp Val Gln Asn Asn Lys Phe Ile Glu 340 345 350 tat gga gaa tat aaa aac aac tac tac ggc aca agt ata gac tca gtt 1103 Tyr Gly Glu Tyr Lys Asn Asn Tyr Tyr Gly Thr Ser Ile Asp Ser Val 355 360 365 cgg tct gtc ctt gct aaa aac aaa gtt tgt ttg ttg gat gtt cag cct 1151 Arg Ser Val Leu Ala Lys Asn Lys Val Cys Leu Leu Asp Val Gln Pro 370 375 380 cat aca gtg aag cat tta agg aca cta gaa ttt aag ccc tat gtg ata 1199 His Thr Val Lys His Leu Arg Thr Leu Glu Phe Lys Pro Tyr Val Ile 385 390 395 ttt ata aag cct cca tca ata gag cgt ttg aga gaa aca aga aaa aat 1247 Phe Ile Lys Pro Pro Ser Ile Glu Arg Leu Arg Glu Thr Arg Lys Asn 400 405 410 415 gca aag att att tca agc aga gat gac caa ggt gca aaa ccc ttc 1295 Ala Lys Ile Ile Ser Ser Arg Asp Asp Gln Gly Ala Ala Lys Pro Phe 420 425 430 aca gaa gaa gat ttt caa gaa atg att aaa tct gca cag ata atg gaa 1343 Thr Glu Glu Asp Phe Gln Glu M et Ile Lys Ser Ala Gln Ile Met Glu 435 440 445 agt caa tat ggt cat ctt ttt gac aaa att ata ata aat gat gac ctc 1391 Ser Gln Tyr Gly His Leu Phe Asp Lys Ile Ile Ile Asn Asp Asp Leu 450 455 460 act gtg gca ttc aat gag ctc aaa aca act ttt gac aaa tta gag aca 1439 Thr Val Ala Phe Asn Glu Leu Lys Thr Thr Phe Asp Lys Leu Glu Thr 465 470 475 475 gag acc cat tgg gtg cca gtg agc tgg tta cat tca taactaagag 1485 Glu His Trp Val Pro Val Ser Trp Leu His Ser 480 485 490 aaatttccat aattgtcttt ttctatagag tgcatgatga aatcaattac agttttggta 1545 gtagggtttt taaatctata tcactgtcat agatgtacaa tcttggttca agttgaatgc 1605 tggttttgtt tgtatctttt tacagcctta tttcaaacgc catgtgttag tataagatcc 1665 gaaatcaaaa tatgcacagt actgtattct aagcaaaacc tcaaaccttc tcgttgtctt 1725 caataccgct ctatctccaa gatgaggctg aaattttcag agagacttag ctagaggctt 1785 agtatgtatg ggagttcagc gcttctgctg gtctcaggtg tggctgctgc tgtcgagttt 1845 gaatgttagc tgttgaaggt atcaattcag cagccatgag cagctccaga cagacaggtg 1905 agctctgctg tttctgggtg gatcatcaca gatttagc cg ggcaggcagt aaggtgtcct 1965 cttactattc aaaaagtgta gactttctta catattcgca atacgttcac agtgtgtgca 2025 ttttaaaata attcttaaag gagtaactga aattttacct tgagtgaatg gccttcataa 2085 tatagcttga gaagtccttt tgagtacctg tcagtgactc aacaacattt aataagggaa 2145 agtagacttt taacagttat tatatatgta acgaaaagcc tttcctttgg gattaatata 2205 agtaagaatg gtagccttgt ggcaagaaat gattacaaag gatattttta tttgtaattc 2265 ctcagaagac aatttatgaa gtcacccaaa atgttatttt agctggtttt ggatttttcc 2325 aataaattag aagaaggatt tctattctaa aacatgtaaa acctgtttta catattactg 2385 atacaattaa agattatttt tcatctatgt gcaatagatc acccctcttt aaattgctct 2445 aagatttatt ttagaaaact tttcatgtga tgttatttct ttgtcatcaa aatgcttgtt 2505 aacactgtcc agacaccatc ctaaccttgc cattgttaaa gaagtttagg aaagactctt 2565 atattgtaaa tatttagatg ggttctctca cttttctttg atactactga ttttcagcaa 2625 gtgaattata taattcaaaa tgctagaaat gtctatccgt tctataagag agcatatcct 2685 gccgttcttg catgcagtga agccctgccc gtcgaaaatc attgcatctg tgactttcaa 2745 agtggaaaaa aaaatgttat ttttttgttg atttgtaaag aga gtttaaa tgtcatgtga 2805 aaaaaaatag aatgtagtaa aattctatat atttatgaaa tattttaaag gcatattttt 2865 ttaaatatca aacggggcta ttcataaaat aaactgattg tatgtcaaga tgtcctaatt 2925 taaaagagta gttttataaa tcatggtcaa cattccatgt aaatatttga gctttacaaa 2985 gatagatcca agtgtgcgat ctgtgcactg cacatttgat agcattattc actggttttc 3045 cttcatactt gtcaagttca tattagaagc agagacaaaa accactccaa tggccttgac 3105 acatagtcac accaaaatag ataatcagac taagtattat ataacaacgt gatccagaca 3165 gtgagttcta agtgtattaa ttaaatagca aaaaattttg tttttaaaaa atgaaagagg 3225 gagggttgcc aacctgaagt cttaagtaga ttgtttgggt agcatatttc cttctttgaa 3285 cattgtctga aattttctat aaatcaagac ttcttgtaca aagaatgatg ggacatatgt 3345 aataattcag gcaatcacct gagtaattta ggcagtccaa attctttacc ctgaaatacc 3405 cacattttaa aaaaattgca gataattgct tcagttattt actttgggga cagagatata 3465 gtgtaaagtg ggagaaactg agtccttttt tggtggtggt aataataaga tgttataaaa 3525 atataacatt ttaaaaaaga aaggtccaga ccttaagcgc agagctagaa caatattttt 3585 taaataatgg ggggaaaagg gggcactttg gtaattttag aaatcagg ta gtatactttt 3645 tttttttttt ttgagacagg gtcttgccat gttgctcagg ctggtcttga actcctgggc 3705 tcaagcaatc ctcctgcctt ggcctcccaa agtgctggga ttacaggcat gatccaccgt 3765 gcccagccgg tagacgtggt cttaaaaaca gtgtttacat ggccatcttg atgcttagaa 3825 agataattga ttaaaattta ataaggcagg gccaactccg agagttcatt gacaacggca 3885 gcaaaaaggc cctgaattct gtactttctt cccccagcct ccttctccag caaggagaat 3945 agcactcctc cctccagaag ccagctccct aagttggagc cactatgtaa gagaagagga 4005 acgttcactt tttaaaattc atatatttaa aaatcaagac caaaaagtaa attctgtact 4065 cctattattg actgtagtca atcaaacata aaaaggtgaa agtaaaattt aattttttac 4125 ccttatttta ctgaccaata tggaagttct tggtatcttt aaggctgacc ttcctggtat 4185 tgtgtaatga ttgaatgtat ctaaactgta ataatttgaa actgacaaac ataaccttct 4245 cagacttaca aaactatgtt ctttctaaag atacagattt ttattatttt attttgacta 4305 ggaaggattt ataaataaat gtaatgaaaa atctttgatc ttaataaagt accttcaaac 4365 agaat 4370

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 25/00 101 A61P 25/18 25/14 35/00 25/18 C12N 15/00 ZNAA 35/00 A61K 37/02 (72) Inventor Daisuke Nakajima 1532-3 Yana, Kisarazu-shi, Chiba F-term in Kazusa DeNA Institute (reference) 4B024 AA01 AA11 AA20 BA80 CA04 DA06 EA04 GA14 HA01 HA11 HA17 4C084 AA06 AA07 AA13 BA35 CA53 CA56 CA59 ZA021 ZA151 ZA181 ZB261 4C086 AA03 EA16 NA14 ZA02 ZA15 ZB26 ZC78 4H045 AA10 BA10 CA40 EA20 EA50 FA74

Claims (5)

[Claims] 1. A DNA consisting of a nucleotide sequence encoding the following polypeptide (a) or (b): (a) SEQ ID NOS: 1 to 234 (provided that SEQ ID NO: 1,
2,6-8,11,14,16,21,23,26-2
8, 33, 36, 37, 40, 41, 44, 49, 5
2, 57, 64, 65, 70, 75 to 77, 79, 8
1,83,84,87,91,98-100,102,
104, 107, 111, 113, 118, 123, 1
26, 131, 134, 135, 137, 138, 14
0, 141, 144, 147, 150-153, 158
~ 160, 164, 166, 168, 172, 174,
176,177,179,185,194-196,1
98, 200, 205-212, 215, 217, 22
2, and 225 to 227 are excluded. A) a polypeptide consisting of an amino acid sequence identical or substantially identical to the amino acid sequence represented by any one of (b) SEQ ID NOs: 1 to 234 (provided that SEQ ID NO.
2,6-8,11,14,16,21,23,26-2
8, 33, 36, 37, 40, 41, 44, 49, 5
2, 57, 64, 65, 70, 75 to 77, 79, 8
1,83,84,87,91,98-100,102,
104, 107, 111, 113, 118, 123, 1
26, 131, 134, 135, 137, 138, 14
0, 141, 144, 147, 150-153, 158
~ 160, 164, 166, 168, 172, 174,
176,177,179,185,194-196,1
98, 200, 205-212, 215, 217, 22
2, and 225 to 227 are excluded. ) In the amino acid sequence shown in any one of, some amino acids are deleted,
A polypeptide consisting of a substituted or added amino acid sequence and having substantially the same biological activity as the function of the polypeptide of (a). 2. DNA of the following (a) or (b): (a) SEQ ID NO: 1 to 234 (provided that SEQ ID NO: 1,
2,6-8,11,14,16,21,23,26-2
8, 33, 36, 37, 40, 41, 44, 49, 5
2, 57, 64, 65, 70, 75 to 77, 79, 8
1,83,84,87,91,98-100,102,
104, 107, 111, 113, 118, 123, 1
26, 131, 134, 135, 137, 138, 14
0, 141, 144, 147, 150-153, 158
~ 160, 164, 166, 168, 172, 174,
176,177,179,185,194-196,1
98, 200, 205-212, 215, 217, 22
2, and 225 to 227 are excluded. And (b) hybridizing under stringent conditions with the DNA encoding the amino acid sequence represented by each of the base sequences represented by any one of (a) to (b), and DN encoding a protein having substantially the same biological activity as the function of the peptide
A. A gene comprising the human DNA according to claim 1 or 2. 4. A recombinant polypeptide of the following (a) or (b): (a) SEQ ID NO: 1 to 234 (provided that SEQ ID NO: 1,
2,6-8,11,14,16,21,23,26-2
8, 33, 36, 37, 40, 41, 44, 49, 5
2, 57, 64, 65, 70, 75 to 77, 79, 8
1,83,84,87,91,98-100,102,
104, 107, 111, 113, 118, 123, 1
26, 131, 134, 135, 137, 138, 14
0, 141, 144, 147, 150-153, 158
~ 160, 164, 166, 168, 172, 174,
176,177,179,185,194-196,1
98, 200, 205-212, 215, 217, 22
2, and 225 to 227 are excluded. A) a polypeptide consisting of an amino acid sequence identical or substantially identical to the amino acid sequence represented by any one of (b) SEQ ID NOs: 1 to 234 (provided that SEQ ID NO: 1
2,6-8,11,14,16,21,23,26-2
8, 33, 36, 37, 40, 41, 44, 49, 5
2, 57, 64, 65, 70, 75 to 77, 79, 8
1,83,84,87,91,98-100,102,
104, 107, 111, 113, 118, 123, 1
26, 131, 134, 135, 137, 138, 14
0, 141, 144, 147, 150-153, 158
~ 160, 164, 166, 168, 172, 174,
176,177,179,185,194-196,1
98, 200, 205-212, 215, 217, 22
2, and 225 to 227 are excluded. ) In the amino acid sequence shown in any one of, some amino acids are deleted,
A polypeptide consisting of a substituted or added amino acid sequence and having substantially the same biological activity as the function of the polypeptide of (a). A recombinant protein comprising the polypeptide according to claim 4.