JP2002297922A - Method of manufacturing and selling medicinal toxicity evaluating hepatic cell chip system using bidirectional electronic system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To quickly and precisely provide a medicinal toxicity evaluating hepatic cell chip system substituting for experiments on animals. SOLUTION: This manufacturing-selling method of a medicinal toxicity evaluating hepatic cell chip system includes respective steps of quickly and precisely disclosing information on a hepatic cell difficult for preservation, and having a large individual difference by using a bidirectional electronic system, retrieving and ordering these product information by a user, and sending a product to the user by accepting, confirming, and manufacturing the product by an entrusted institution. In addition, the manufacturing-selling method of a medicinal toxicity evaluating hepatic cell chip evaluating system includes respective steps of quickly and precisely disclosing information on the medicinal toxicity evaluating hepatic cell chip system, retrieving and ordering these product information by the user, and sending the product to the user by accepting, confirming, and manufacturing the product by the entrusted institution. Furthermore, the manufacturing-selling method of medicinal toxicity evaluating hepatic cell chip system includes respective steps such as registration of toxicity data and an inquiry of the toxicity data.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention relates to a method of manufacturing and selling a toxicity evaluation system using liver cells, which uses a two-way electronic system such as the Internet or telephone communication, instead of the conventional toxicity evaluation method using animal experiments. In order to sell hepatocyte chips for drug toxicity evaluation in which hepatocytes are cultured, which are difficult to store and are derived from living organisms and have large individual differences, product information is released promptly as soon as hepatocytes are received using a two-way electronic system. , Using a two-way electronic system, supplying a hepatocyte chip for drug toxicity evaluation in response to the user's request accurately and promptly, and evaluating the toxicity in a hepatocyte chip evaluation system for drug toxicity evaluation sent separately, The data registration and the collation with the stored data are performed by the two-way electronic system according to the above.

[0002]

2. Description of the Related Art As a cell chip as an alternative model for animal experiments, products using skin cells and the like are currently on the market.
Actually, there was no one using liver cells that are responsible for drug metabolism in a living body. Hepatocytes are difficult to preserve, and because they are derived from living organisms, individual differences are large. Furthermore, products using cells typified by cell chips and the like so far are mainly sold in catalogs and pamphlets. Despite individual differences such as functional characteristics of cells due to biological origin, products are received one after another. Since the product is produced using cells of another individual, the functional characteristics of the cells used in the product to be purchased have been provided to the user with unclear functional characteristics. Moreover, there is no system for registering and referencing the evaluation data obtained by the user individually.

[0003]

[0004] More than 20 million experimental animals are used annually to evaluate the toxicity of new drugs, cosmetics and the like. At present, a product using skin cells or the like is commercially available as a model that substitutes for this animal experiment, but the toxicity of a drug is evaluated only by viability of cells.
Furthermore, none of the conventional cell chips use liver cells (hepatocytes) that actually carry out drug metabolism. What the user wants is to evaluate the toxicity of the largest metabolic organ in the liver in the liver.However, it is difficult to store the liver cells. Manufacturing process, supply method, optimal toxicity evaluation method, etc. have not been established. In addition, animal experiments to evaluate drug toxicity up to now have been conducted at each company level, and it was difficult to refer to toxicity data using a two-way electronic system.

[0004]

SUMMARY OF THE INVENTION The present invention relates to pharmaceuticals, cosmetics,
Construct a two-way electronic system between the user such as a chemical manufacturer and the commissioned organization, and it is difficult to save long-term product management because it is difficult to manage individual differences of hepatocytes, such as race, gender,
Age, drug administration history, etc. are released quickly and accurately using a two-way electronic system such as the Internet at the same time as securing hepatocytes, and drugs using hepatocytes that are secured in response to the needs of users accurately Because hepatocyte chips for toxicity evaluation can be manufactured and transported, it is possible to provide high quality products. In other words, the product information of the hepatocyte chip for drug toxicity evaluation registered in the computer of the consignment organization, especially information on the functional characteristics of hepatocytes that are difficult to store and have large individual differences due to their biological origin, can be transmitted to the Internet or other sources. Quickly and accurately publish using an electronic system; a user who needs a hepatocyte chip for drug toxicity evaluation, such as a pharmaceutical, cosmetic, or chemical manufacturer, receiving product information using an interactive electronic system; Receiving an order using a two-way electronic system; setting manufacturing conditions for producing a hepatocellular chip for drug toxicity evaluation according to the order; a hepatocyte chip for evaluating drug toxicity according to the manufacturing conditions Issuing instructions for creating a hepatocellular chip for drug toxicity evaluation to a user It is a manufacturing and sales process of hepatocyte chip drug toxicity evaluation, including the step of receiving the payment from the user; step of sending the hepatocyte chip drug toxicity evaluation to the user; indicates the step issuing. Furthermore, in the method for producing and selling a hepatocyte chip for drug toxicity evaluation, which includes a step of sending the hepatocyte chip for drug toxicity evaluation to the user, since there is a large individual difference in the functional characteristics of the hepatocytes used, Assigning a lot number to the hepatocyte chip for evaluation; giving instructions for storing the hepatocyte chip for evaluating drug toxicity in association with the lot number; and transmitting the lot number to the user; The method of manufacturing and selling chips is preferred. Furthermore, in the step of setting the conditions for manufacturing the hepatocyte chip for drug toxicity evaluation according to the order and the step of issuing an instruction for manufacturing the hepatocyte chip for drug toxicity evaluation according to the manufacturing conditions,
Before giving directions for the manufacture of a hepatocyte chip for drug toxicity evaluation, instructions for manufacturing a sample of a hepatocyte chip for drug toxicity evaluation using hepatocytes with large individual differences in functional characteristics due to biological origin Manufacturing and sales of a hepatocellular chip for drug toxicity evaluation including the steps of: sending a sample to a user; giving instructions for sending the sample to a user; receiving a user evaluation of the sample; and reviewing manufacturing conditions based on the evaluation result. The method is more preferred. Further, in the step of sending the hepatocyte chip for drug toxicity evaluation to the user and the step of receiving the user evaluation of the sample, the information on the system for evaluating toxicity using the hepatocyte chip for drug toxicity evaluation sent to the user is used. Publishing from a registered agency computer using a two-way electronic system such as the Internet; receiving a product information using a two-way electronic system by a user; Receiving and confirming the order; accepting and confirming the order contents; setting design conditions for manufacturing the evaluation system; issuing an instruction for manufacturing the evaluation system based on the design conditions; evaluating the manufactured drug toxicity Instructions for sending the hepatocyte chip evaluation system for Step;
A method of manufacturing and selling a hepatocellular chip evaluation system for drug toxicity evaluation, comprising the steps of: sending a hepatocellular chip evaluation system for drug toxicity evaluation to a user; and receiving a payment from the user. Furthermore, in the step of sending the hepatocyte chip for drug toxicity evaluation to the user, the step of receiving the user evaluation of the sample, and the step of sending the hepatocyte chip evaluation system for drug toxicity evaluation to the user, Registering data using a two-way electronic system; receiving an inquiry about toxicity evaluation data using a two-way electronic system; collating the contents of the inquiry with stored data using a two-way electronic system; Most preferred is a method for manufacturing and selling a hepatocyte chip evaluation system for drug toxicity evaluation, which includes the step of providing information to a user using a two-way electronic system.

[0005]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring to FIG. 1, the commissioned organization has registered the product information on the hepatocyte chip for drug toxicity evaluation registered in the computer, especially the function of the hepatocyte, which is difficult to store and is derived from a living body and has a large individual difference. Information on characteristics is disclosed quickly and accurately using a two-way electronic system such as the Internet (arrow 101). Pharmaceuticals, cosmetics, chemical manufacturers, etc., who are the users, search for product information on the hepatocyte chip for drug toxicity evaluation using a two-way electronic system such as the Internet (arrow 102), and use the two-way electronic system or the like to outsource the contract. (Arrow 108).
The commissioned organization confirms the contents of the order and produces a hepatocyte chip for drug toxicity evaluation (arrow 109) and sends it to the user (arrow 110). At this time, customer information (arrow 112), product information (arrow 113), and the like are stored in a computer, and an optimal sales method is selected. Further, the user can request a sample of a hepatocyte chip for drug toxicity evaluation using hepatocytes having greatly different functional characteristics (arrow 103), and the commissioned organization confirms the request and produces (arrow 104) and sends it (arrow 103). Arrow 1
05) Toxicity was evaluated in the sample (arrows 106, 10
7) The product information and the like can be consulted to the commissioned organization by the interactive electronic system. At this time, customer information (arrow 114), product information (arrow 115), and the like are stored in a computer, and an optimal sales method is selected. The remittance can be made quickly and safely using an interactive electronic system or the like (arrow 111). Next, referring to FIG. 2, the consignment institution publishes the product information on the hepatocellular chip evaluation system for drug toxicity evaluation registered in the computer on the Internet or in a pamphlet (arrow 206). Pharmaceuticals, cosmetics, chemical manufacturers, etc., who are users, search the product information of the hepatocellular chip evaluation system for drug toxicity evaluation transmitted by the commissioned organization using an interactive electronic system such as the Internet (arrow 201), and use the interactive electronic system. The order is made by using the method (arrow 202). The trustee confirms the order contents to the user, produces an evaluation system (arrow 203), and sends it (arrow 204). The customer information at this time (arrow 20)
7) The product information (arrow 208) and the like are stored in the computer, and the most suitable sales method is selected. Remittance is also performed quickly and safely using an interactive electronic system or the like (arrow 205). Furthermore, product support and the like are performed quickly and accurately using the two-way electronic system. Next, referring to FIG. 3, the user sends the toxicity evaluation data obtained by the hepatocyte chip evaluation system for drug toxicity evaluation and the toxicity evaluation data obtained by the hepatocyte chip for drug toxicity evaluation to a contracting organization using a bidirectional electronic system or the like. After receiving the data (arrow 301), the data can be registered in the computer (arrow 302). Conversely, when the user wants to refer to the past drug toxicity evaluation data, he / she requests the inquiry and the data reference is accepted (arrow 305). Data is provided (arrows 303, 304) and the user can receive the data (arrow 306).

[0006]

EXAMPLES The method for producing and selling the hepatocyte chip system for drug toxicity evaluation of the present invention will be described below with reference to examples. However, the examples do not limit the validity of the present invention.

[0007]

[Example 1] Hepatocyte chip system for drug toxicity evaluation A contracting organization for the manufacture and sale of hepatocyte chips was registered in a computer. Information about the functional characteristics of the Internet is quickly and accurately disclosed using a two-way electronic system such as the Internet. Pharmaceutical, cosmetics, chemical manufacturers, etc., who are users, select a hepatocyte chip for drug toxicity evaluation using hepatocytes with functional characteristics according to the purpose from product information searched using an interactive electronic system such as the Internet. Using a two-way electronic system or the like, request an order or provide a sample to a consignment organization. After confirming the contents of the user's order, the commissioned organization immediately produces a hepatocyte chip for drug toxicity evaluation in response to the user's request and sends it along with the lot number. If a free sample is provided and the evaluation of the free sample by the user is not preferable, a product of another lot number is provided as a free sample. When an order is received, the commissioned organization uses a two-way electronic system or the like to confirm the contents of the user's order and immediately produce a hepatocyte chip for drug toxicity evaluation in response to the user's request. After production, it is sent to the user together with the lot number, and remittance is performed quickly and safely using an interactive electronic system or the like. At this time, customer data, product data, and the like are stored in a computer. Also,
The contracting organization for the manufacture and sale of the hepatocellular chip system for drug toxicity evaluation publishes the product information on the hepatocellular chip evaluation system for drug toxicity evaluation registered in the computer on the Internet and in pamphlets. Pharmaceutical users,
Cosmetics, chemical manufacturers, etc. select a hepatocellular chip evaluation system for drug toxicity evaluation having a function according to the purpose from product information on the Internet or pamphlets, and place an order with a commissioned institution using a two-way electronic system. After confirming the contents of the user's order, the contracting organization immediately produces an evaluation system in response to the user's request. After production, it is sent to the user, and remittance is performed quickly and safely using an interactive electronic system or the like. The customer data and product data at this time are stored in a computer. Furthermore, the user can register the drug toxicity evaluation data obtained by the above-mentioned drug toxicity evaluation hepatocyte chip and the drug toxicity evaluation hepatocyte chip evaluation system in the computer of the contracting institution using an interactive electronic system or the like. Conversely, when it is desired to refer to past drug toxicity evaluation data, the data can be provided.

[0008]

(1) By using a two-way electronic system capable of quick and accurate mutual communication, it becomes possible to distribute a hepatocyte chip for drug toxicity evaluation using hepatocytes that are difficult to store. Was. (2) By using a two-way electronic system capable of quick and accurate mutual communication, the user can select hepatocytes from the living body, which have a large individual difference, according to the functional characteristics, thereby improving quality. It has become possible to distribute hepatocyte chips for high drug toxicity evaluation. (3) The use of the two-way electronic system has made payment of the payment safe and easy. (4) Toxicity assessment data registration and toxicity assessment data reference using a two-way electronic system, which are not available in animal experiment data for toxicity assessment, are now possible. (5) The use of a two-way electronic system capable of quick and accurate mutual communication has made it possible to distribute a hepatocyte chip evaluation system for drug toxicity evaluation that meets the needs of users.

[0009]

[Changeable range] (I) The hepatocyte type used may be any animal type, cancer cell type, or established cell type as long as at least drug toxicity can be evaluated. (II) The hepatocyte chip for evaluating drug toxicity may be of any material, form, and name as long as at least the toxicity can be evaluated. (III) The hepatocyte chip evaluation system for drug toxicity evaluation may be any system as long as at least toxicity evaluation can be performed. (IV) As long as hepatocytes used are obtained from at least one individual, those obtained from any number of individuals may be used simultaneously.

[0010]

[A range that can be changed] (A) Any medium may be used as long as at least mutual information can be exchanged with the two-way electronic system. (B) The product information on the drug toxicity evaluation hepatocyte chip evaluation system and the drug toxicity evaluation hepatocyte chip may be any information as long as at least the details of these products can be understood. (C) The remittance means may be any means as long as at least payment of the product price is possible. (D) Any means or medium may be used for inquiring the evaluation data as long as at least inquiring with registered data is possible.

[0011]

[Brief description of the drawings]

FIG. 1 is an explanatory view showing steps in one embodiment of the production and sale of hepatocyte chips for evaluating drug toxicity according to the method of the present invention.

FIG. 2 is an explanatory view showing steps in one system for manufacturing and selling a hepatocyte chip evaluation system for evaluating drug toxicity according to the method of the present invention.

FIG. 3 is an explanatory diagram showing steps in an implementation system of toxicity data registration / toxicity data inquiry regarding the hepatocyte chip system for drug toxicity evaluation of the method of the present invention.

[0012]

[Explanation of symbols]

101 Using a two-way electronic system, product information on the hepatocyte chip for drug toxicity evaluation registered in the computer of the consignment organization, particularly information on the functional characteristics of hepatocytes that are difficult to store and are of great biological origin and have large individual differences, can be obtained quickly and interactively. Exact disclosure step 102 Searching for product information on the hepatocyte chip for drug toxicity evaluation by a user, such as a pharmaceutical, cosmetics, or chemical manufacturer, using a two-way electronic system 103 Functional properties differ greatly because the user is of biological origin Step 104 of requesting a sample of a hepatocyte chip for drug toxicity evaluation using hepatocytes using a two-way electronic system 104 Step of receiving and confirming the request for the sample by a contracting organization and step 105 of producing the sample Sending step 106 Evaluating the toxicity of the sample and obtaining good knowledge Step 107 When the toxicity is evaluated in the sample and no good knowledge is obtained Step 108 The user orders a hepatocyte chip for drug toxicity evaluation to a contracting organization using a two-way electronic system or the like 109 Step 110: The contractor accepts and confirms the contents of the order to produce the hepatocyte chip for drug toxicity evaluation. Step 110: The contractor sends the hepatocyte chip for drug toxicity evaluation to the user. Step of paying safely 112 Registering the customer information of the ordering hepatocyte chip for drug toxicity evaluation in the computer of the consignment institution 113 Registering the product information on the ordered hepatocyte chip for drug toxicity evaluation in the computer of the consignment institution Step 114 Request a sample of a hepatocyte chip for drug toxicity evaluation Step to register the product information in the consignment institutions of computer related to liver cell chip for drug toxicity evaluation has been requested step 115 sample to register the customer information to the commission agencies of computers was

[0013]

[Explanation of symbols]

201 Step of searching for product information on the hepatocellular chip evaluation system for drug toxicity evaluation by a user, such as a pharmaceutical, cosmetics, or chemical manufacturer, using a two-way electronic system 202. Step 203 of ordering a hepatocellular chip evaluation system for drug toxicity evaluation 203 Contracting organization accepts and confirms the contents of the order and produces a hepatocellular chip evaluation system for drug toxicity evaluation 204 Consignment organization evaluates hepatocellular chip evaluation for drug toxicity Step 205 of sending the system to the user Step 205 of promptly and safely paying the price using an interactive electronic system 206 Interacting with the product information on the hepatocellular chip evaluation system for drug toxicity evaluation registered in the computer of the contracting organization Publish quickly and accurately using electronic systems The step of registering the product information into the computer's delegated authority regarding Step 207 drug toxicity hepatocytes chip evaluation step 208 ordered hepatocytes chip evaluation system for drug toxicity evaluation registers the customer information systems ordered consignment engine computer for evaluation

[0014]

[Explanation of symbols]

Step 301: A user registers a drug toxicity evaluation hepatocyte evaluation system and drug toxicity evaluation data obtained by the drug toxicity evaluation hepatocyte chip to a commissioned institution using a two-way electronic system or the like. Step 3: the drug accepting agency receives the drug toxicity evaluation data and records it on the computer 303 Step of accessing the computer of the commissioning agency to provide the inquiry data 304 Step of receiving the inquiry data from the computer of the commissioning agency 305 Inquiry requesting past drug toxicity evaluation data using an electronic system 306 Receiving drug toxicity evaluation data inquired by a user from a consignment institution using an interactive electronic system

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Toshihiro Akaike 3-1-1 Asahi, Matsumoto-shi, Nagano Prefecture Shinshu University Graduate School of Medicine (72) Inventor Yoshiyuki Kondo 3-1-1, Tsuneta, Ueda-shi, Nagano Prefecture Shinshu University, Faculty of Textile Science and Technology, Department of Functional Polymers (72) Inventor, Naoki Negishi 3-1-1 Asahi, Matsumoto-shi, Nagano Prefecture No. 1 Shinshu University Graduate School of Medicine (72) Inventor Nobuhiro Sugihara 3-1-1 Asahi, Matsumoto-shi, Nagano F-term (reference) 4B029 AA08 BB11 CC03 GA08 GB06 GB10 4B063 QA05 QQ08 QQ20 QR77 QR82 QS39

Claims (5)

[Claims] 1. Product information of a hepatocyte chip for drug toxicity evaluation registered in a computer of a consignment organization, particularly information on functional characteristics of hepatocytes which are difficult to store and which have a large individual difference due to their biological origin, are distributed on the Internet or the like. Swiftly and accurately publishing using a two-way electronic system; step of receiving product information using a two-way electronic system for users who need a hepatocellular chip for drug toxicity evaluation, such as pharmaceutical, cosmetic, and chemical manufacturers Receiving an order from a user using the interactive electronic system;
Setting the manufacturing conditions for preparing the hepatocyte chip for drug toxicity evaluation according to the order; providing an instruction for preparing the hepatocyte chip for drug toxicity evaluation according to the manufacturing conditions; Manufacturing a hepatocyte chip for drug toxicity evaluation including the steps of sending an instruction to send the hepatocyte chip for toxicity evaluation to the user; sending the hepatocyte chip for drug toxicity evaluation to the user; and receiving the price from the user.・ Sales method. 2. A method for producing and selling a hepatocellular chip for drug toxicity evaluation, which includes a step of transmitting the hepatocellular chip for drug toxicity evaluation to a user, because of a large individual difference in the functional characteristics of the hepatocytes used. Assigning a lot number to the hepatocyte chip for evaluating drug toxicity; giving instructions for storing the hepatocyte chip for evaluating drug toxicity in association with the lot number; and transmitting the lot number to the user. Of manufacturing and selling hepatocyte chips for medical use. 3. A step of setting conditions for manufacturing a hepatocyte chip for evaluating drug toxicity according to an order and a step of issuing an instruction for manufacturing a hepatocyte chip for evaluating drug toxicity according to the manufacturing conditions. Before issuing an instruction for the production of a hepatocyte chip for drug toxicity evaluation, to produce a sample of a hepatocyte chip for drug toxicity evaluation using hepatocytes having large individual differences in functional characteristics due to biological origin. Production of a hepatocyte chip for drug toxicity evaluation including the steps of: giving an instruction; giving an instruction to send a sample to a user; receiving a user evaluation of the sample; and reviewing manufacturing conditions based on the evaluation result. How to sell. 4. A system for evaluating toxicity using the drug toxicity evaluation hepatocyte chip sent to the user in the step of sending the drug toxicity evaluation hepatocyte chip to the user and the step of receiving the user evaluation of the sample. Publishing information about the product from the registered agency computer using a two-way electronic system such as the Internet; receiving a product information using the two-way electronic system; Receiving using an electronic system; accepting and confirming the order contents; setting design conditions for manufacturing the evaluation system; issuing instructions for manufacturing the evaluation system based on the design conditions; Instructions for sending the hepatocellular chip evaluation system for drug toxicity evaluation to users A method for producing and selling a hepatocellular chip evaluation system for drug toxicity evaluation, comprising: sending a hepatocellular chip evaluation system for drug toxicity evaluation to a user; and receiving a price from the user. 5. The method according to claim 5, wherein the step of sending the hepatocyte chip for drug toxicity evaluation to the user, the step of receiving the user evaluation of the sample, and the step of sending the hepatocyte chip evaluation system for drug toxicity evaluation to the user are performed. Registering data relating to toxicity evaluation using an interactive electronic system; receiving an inquiry relating to toxicity evaluation data using an interactive electronic system; collating the inquiry contents with stored data using an interactive electronic system; A method for producing and selling a hepatocellular chip evaluation system for drug toxicity evaluation, comprising providing information based on a result to a user using a two-way electronic system.