JP2002277368A - Measuring instrument, and analyzer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a tecnique for stabilizing an oscillation frequency of a quartz oscillator in a sample at a constant value. SOLUTION: This measuring instrument of the present invention has a cell 20 having a storage part 20a for storing a prescribed solution 7, the quartz oscillator 3 having a pair of electrodes 31, 32 connectable to a prescribed oscillation source, of which the one electrode 31 is constituted to be immersed into the solution 7, and a stirring member 50 for stirring the solution 7. The sample is supplied via an introduction pipe 55 and the stirring member 50, and the solution 7 is discharged to a discharge part 9 via a discharge pipe 29.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an analyzer provided with a measuring cell, and more particularly, to an analyzer in a liquid by detecting a frequency characteristic such as a resonance frequency and a phase of a crystal oscillator immersed in the liquid. The present invention relates to techniques for analyzing components and analyzing reaction rates.

[0002]

2. Description of the Related Art In recent years, a crystal oscillator having a specific substance disposed on an electrode surface is oscillated in a liquid such as blood, for example.
Analyze the reaction speed of specific components in a sample by using the phenomenon that the components in the liquid bind to the surface of the crystal oscillator and the oscillation frequency of the crystal oscillator decreases according to the mass of the components. An analyzer has been proposed.

FIG. 9 shows the configuration of an example of such an analyzer. As shown in FIG.
01 is a computer 102 and a frequency counter 103
, An oscillator 104, a DC power supply 105, and a crystal oscillator 106.

The quartz oscillator 106 is a disk 1 made of quartz.
06a and the electrodes 106 respectively disposed on the front and back sides thereof.
b and 106c, of which, for example, the electrode 106b is configured to be able to oscillate even when immersed in a liquid. A predetermined reactant (not shown) configured to react with a specific component and adsorb the component is disposed on the surface of the electrode 106b. When immersed in a liquid, it is exposed to the liquid.

[0005] The other electrode 106c is covered with a protective portion (not shown) so as not to be exposed to the solution.

In order to analyze a reaction state between a specific component in a sample such as blood and a reaction material by the analyzer 101 having the above-described configuration, first, the crystal oscillator 106 is placed in the atmosphere. , The DC power supply 105 is activated and the oscillator 10
4 is applied with a DC voltage. Thereby, the oscillator 10
4 oscillates at a predetermined oscillation frequency.

The change in the oscillation frequency of the crystal oscillator 106 is shown by a curve (X) in FIG. The horizontal axis of the graph in FIG. 10 indicates time, and the vertical axis indicates the oscillation frequency of the crystal oscillator 106. The symbol F _o represents the crystal oscillator 10 in the atmosphere.
6 shows the oscillation frequency of No. 6.

A quartz oscillator 106 oscillating in the atmosphere at an oscillating frequency _Fo is applied to a solution 1 placed in a cell 107.
08. In FIG. 10, the time when the crystal oscillator 106 is immersed in the solution 108 is indicated by _a symbol ta. When the crystal oscillator 106 is immersed in the solution 108, the load applied to the crystal oscillator 106 becomes larger than that in the atmosphere, so that the oscillation frequency of the crystal oscillator 106 is greatly reduced as shown by a curve (X). Attenuates greatly and eventually stabilizes at a predetermined frequency.

[0009] FIG. 10 shows the predetermined frequency in the code F _s. The oscillation frequency of the crystal oscillator 106 is constantly detected by the frequency counter 103, and the detection result is output to the computer 102 as needed. The computer 102 determines that the oscillation frequency has been stabilized when the fluctuation of the oscillation frequency is within the predetermined range for a predetermined time or more, and notifies the user to that effect. FIG.
In at reference numeral F _s, the oscillation frequency of the crystal oscillator 106 is shown that stable.

[0010] The user oscillation frequency after being notified that stabilized at F _s, injecting the sample to be analyzed in the cell 107. In FIG. 10, time t _b indicates the time at which the sample was charged. When the sample is injected into the cell 107, the sample is mixed with the solution 108 to generate a sample liquid, and a specific component in the sample liquid is converted into one electrode 1 of the crystal oscillator 106.
06b reacts with the reactant disposed on the surface and is adsorbed on the surface of the reactant. Then, the oscillation frequency of the crystal oscillator 106 decreases according to the mass of the adsorbed component.

As described above, the computer 102 includes the crystal oscillator 10 which is inputted from the frequency counter 103 as needed.
From the oscillation frequency of No. 6, the reaction state of the specific component adsorbed on the surface of the reaction material can be analyzed. As an example of the analysis, in order to determine the reaction rate between the reaction material and a specific component in the sample, first, in FIG. 10, after charging the sample, the quartz crystal at a predetermined time Δt between a predetermined time t _c and a predetermined time t _d is used. The variation ΔF of the oscillation frequency of the oscillator 106 is obtained. The change amount ΔF of the oscillation frequency of the crystal oscillator 106 and the mass Δm of the component adsorbed on the surface of the reaction material during the predetermined time Δt are represented by C
Is a predetermined constant, it is known that a relational expression of ΔF = −C × Δm (1) is established. From the above expression (1), it is known that a specific expression adsorbed on the surface of the reaction material in a predetermined time is obtained. Since the mass change Δm of the component is determined, the reaction rate between the reactant and the specific component can be determined.

[0012]

By the way, in a cell structure having one crystal oscillator 106 as in the prior art,
Only the reaction state when one type of specific component reacts with one type of reactant can be analyzed.

Therefore, in order to simultaneously analyze the reaction states of a plurality of components contained in a sample or a plurality of samples, a plurality of quartz oscillators and a plurality of reaction materials are prepared, and each is immersed in a solution. It is necessary to detect the oscillation frequency of each crystal oscillator in the state.

However, when a plurality of crystal oscillators 106 are to be incorporated into one device, the conventional cell 107 has a problem that the device becomes large and complicated.

On the other hand, if a large number of cells 107 are to be incorporated into one device, the size of the cells 107 must be reduced, so that it takes time to inject and discharge a solution and a sample into the cells 107. For this reason, the measurement operation cannot be performed efficiently.

The present invention has been made in order to solve the above-mentioned problems of the prior art, and an object of the present invention is to provide a small-sized measuring device and an analyzing device capable of performing work efficiently.

[0017]

According to a first aspect of the present invention, there is provided a measuring cell having a storage section for storing a predetermined sample liquid, and a measuring cell connected to a predetermined oscillation source. An oscillator having a pair of possible electrodes, one of the pair of electrodes being configured to be immersed in the sample liquid; and an oscillator for discharging the sample liquid to the outside of the measurement cell. A measuring device having a liquid discharge unit.

According to a second aspect of the present invention, there is provided a measuring cell having a storage portion for storing a predetermined sample liquid, and a pair of electrodes connectable to a predetermined oscillation source. A measurement device comprising: an oscillator configured to immerse one electrode in the sample liquid; and a liquid stirring unit for stirring the sample liquid.

According to a third aspect of the present invention, there is provided a measuring cell having a storage section for storing a predetermined sample liquid, and a pair of electrodes connectable to a predetermined oscillation source. A measuring device comprising: an oscillator configured to immerse one electrode in the sample liquid; and a liquid introduction unit for introducing the sample liquid into a housing of the measurement cell. .

According to a fourth aspect of the present invention, in the first aspect of the present invention, a liquid stirring section for stirring the sample liquid is provided.

According to a fifth aspect of the present invention, in any one of the first or second aspects of the present invention, there is provided a liquid introducing section for introducing the sample liquid into the accommodating section of the measuring cell. And

According to a sixth aspect of the present invention, in the third aspect of the invention, there is provided a liquid discharging section for discharging the sample liquid to the outside of the measuring cell, and a liquid stirring section for stirring the sample liquid. And characterized in that:

According to a seventh aspect of the present invention, in any one of the fourth to sixth aspects, the liquid discharge section is provided in the liquid stirring section.

[0024] According to an eighth aspect of the present invention, in any one of the fifth to seventh aspects, the liquid introduction section is provided in the liquid stirring section.

[0025] The ninth aspect of the present invention is the second aspect of the present invention.
9. The invention according to any one of 6, 7, and 8, wherein the liquid stirring section is configured to move in a predetermined direction.

The invention according to claim 10 is the invention according to claims 1 to 9
The invention according to any one of the first to third aspects, wherein the oscillator is provided near the bottom of the measurement cell and integrally with the bottom.

According to an eleventh aspect of the present invention, there is provided the measuring device according to any one of the first to tenth aspects, wherein a plurality of the measuring cells are arranged and immersed in a sample liquid of a predetermined measuring cell. An analyzer configured to determine an amount of the component in the liquid that adheres to the oscillator based on a frequency characteristic of the oscillator.

In the case of the present invention, by having a liquid discharging portion for discharging the sample liquid to the outside of the measuring cell,
The sample liquid for which the measurement has been completed can be quickly discharged to the outside of the measurement cell, whereby the measurement operation can be performed efficiently.

Further, according to the present invention, the provision of the liquid stirring section for stirring the sample liquid allows the introduced sample to be quickly mixed, thereby enabling efficient measurement work. become.

Further, according to the present invention, the provision of the liquid discharge section for discharging the sample liquid to the outside of the measurement cell allows the sample liquid to be rapidly discharged to the measurement cell. The measurement operation can be performed efficiently.

Furthermore, according to the present invention, the provision of the liquid introducing section for introducing the sample liquid into the accommodating section of the measuring cell allows the sample liquid to be quickly introduced into the measuring cell. This makes it possible to perform the measurement work more efficiently.

On the other hand, according to the present invention, it is possible to prevent the frequency of the oscillator from being disturbed by the reflected wave from the liquid surface of the sample liquid by irregularly reflecting the vibration of the sample liquid in the liquid stirring section. Therefore, more accurate measurement can be performed.

On the other hand, according to the present invention, by providing the liquid introducing section in the liquid stirring section, it is possible to obtain a measuring device which can simply and surely introduce the liquid into the measuring cell.

Further, according to the present invention, by providing the liquid discharge section in the liquid agitating section and also using them, it is possible to obtain a space-saving small measuring device.

According to the present invention, the oscillator is provided integrally near the bottom of the measuring cell, so that it is not necessary to dispose the oscillator in the accommodating portion of the measuring cell unlike the prior art. Space can be omitted,
The size of the measuring cell can be reduced.

According to a tenth aspect of the present invention, there is provided a measuring device according to any one of the first to ninth aspects, wherein a plurality of the measuring cells are arranged, and a sample liquid of a predetermined measuring cell is provided. An analyzer configured to determine the amount of the component in the liquid that adheres to the oscillator based on the frequency characteristics of the oscillator immersed in the oscillator.

According to the present invention, it is possible to provide an analyzer having a small and simple configuration capable of efficiently measuring and analyzing a large number of sample liquids.

[0038]

Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 is a schematic configuration diagram of an analyzer of the present embodiment, FIG. 2A is a cross-sectional view of a measurement cell of the present embodiment, and FIG. 2B is a crystal oscillator of the measurement cell. FIG. 2C is a cross-sectional view of the crystal oscillator of the measurement cell.

As shown in FIG. 1, an analyzer 1 according to the present embodiment includes a cell (measurement cell) 2 having a crystal oscillator (oscillator) 3 to be described later, and an oscillator for oscillating the crystal oscillator 3. An oscillator 4 having an oscillator 40 and a DC power supply 41, a frequency counter 5 for detecting the oscillation frequency of the crystal oscillator 3, and a computer 6 for controlling the operation of the frequency counter 5 and performing predetermined information processing. It has.

In the analyzer 1, the crystal oscillator 3 immersed in a solution 7 in a cell body 20 described later.
Based on the frequency characteristics described above, the amount of the component adhering to the crystal oscillator 3 is determined.

As shown in FIG. 2A, the cell 2 of the present embodiment has a cylindrical cell body 20 such as a cylinder, for example, and a crystal oscillator 3 is disposed near the bottom of the cell body 20. Have been.

Here, the cell main body 20 is formed of a translucent resin such as an acrylic resin in consideration of the easiness of observing the inside.

As shown in FIGS. 2B and 2C, the quartz oscillator 3 has a disk-shaped base 30 made of, for example, quartz.
And a pair of electrodes 31 and 32 made of, for example, gold, which are arranged on the front side and the back side of the base 30, respectively.

In the case of the present embodiment, a flange portion 21 is formed at the bottom of the inner wall of the cell body 20, and this flange portion 2 is formed.
The crystal oscillator 3 is integrally fixed so as to cover the opening 22 inside 1 from the bottom side of the cell body 20.

In this case, the crystal oscillator 3 is adhered to the bottom edge of the flange portion 21 by, for example, an adhesive, and further disposed between the crystal oscillator 3 and a pedestal 23 sealed at the bottom end of the cell body 20. The springs 24 and 25 are pressed against the bottom edge of the flange 21.

Thus, the accommodating portion 20a of the cell body 20
The solution (sample liquid) 7 injected into the cell body 20 is blocked by the crystal oscillator 3 so that the solution 7 does not leak from the bottom side of the cell body 20. Is introduced, only the electrode 31 on the front side of the crystal oscillator 3 is exposed to the solution 7 and the electrode 3 on the rear side is exposed.
2 is not exposed to solution 7.

On the other hand, on the surface of the electrode 31 on the front surface side of the base 30, a reaction material 33 configured to react with a specific component and adsorb the component is disposed. It is configured to be exposed to the solution 7 while being introduced.

As shown in FIG. 2A, the pedestal 23
A pair of terminal pins (connection terminal portions) 26 and 27 for connecting to external terminals (not shown) are fixed. here,
The terminal pins 26 and 27 are sealed to the pedestal 23 while being insulated from each other by, for example, a glass seal 28. The terminal pins 26 and 27 are connected to the crystal oscillator 3
Are electrically connected to the electrodes 31 and 32, respectively, so that the electrodes 31 and 32 of the crystal oscillator 3 can be connected to external terminals from the bottom side of the cell body 20.

The bottom of the cell body 20 is provided with a hole 20b communicating with a space surrounded by the inner wall of the cell body 20, the crystal oscillator 3, and the pedestal 23. The holes 20b serve to discharge gas generated from an adhesive for fixing the crystal oscillator 3 and the pedestal 23 and to prevent dew condensation during storage or measurement, and are particularly provided from these viewpoints. Is preferable.

Further, in the present embodiment, a stirring member 50 for stirring the solution 7 in the cell body 20 is provided. The stirring member 50 includes, for example, a disk-shaped stirring portion 51 having a size that can be inserted into and removed from the cell body 20, and a rod-shaped support portion 52 integrally formed with the stirring portion 51. I have.

The support section 52 of the stirring member 50 is attached to a drive section 53 having a predetermined drive mechanism. The drive unit 53 includes a control unit 10 connected to the computer 6.
The stirrer 51 of the stirrer 50 moves up and down in the cell body 20.

The support portion 52 of the stirring member 50 is provided with an introduction hole (liquid introduction portion) 54 for introducing a predetermined liquid into the cell body 20. The introduction hole 54 is provided with a pump (not shown) or the like. Pipe (liquid introduction section) to supply section 8 having
55.

The supply unit 8 is connected to the computer 6 via the control unit 10 and is configured to perform predetermined processing.

As shown in FIG. 2A, a discharge hole 20c for discharging the solution 7 in the cell body 20 is provided at the bottom of the cell body 20. As shown in FIG. Reference numeral 20c is connected to a discharge unit 9 having a pump and the like (not shown) via a discharge pipe 29. The supply unit 8 is connected to the computer 6 via the control unit 10, and is configured to perform a predetermined process.

According to the present embodiment having such a configuration, since the liquid is introduced from the supply unit 8 through the liquid introduction unit, the operation of introducing the liquid can be performed quickly. The measurement operation can be performed more efficiently.

In particular, in the present embodiment, since the liquid is introduced by providing the introduction hole 54 in the support portion 52 of the stirring member 50, the liquid can be simply and reliably introduced into the cell 2. A measuring device is obtained.

In this embodiment, since the solution 7 is agitated by the agitating member 50, the introduced sample can be rapidly mixed, thereby enabling efficient measurement work. Becomes possible.

Further, according to the present embodiment, since the solution 7 is configured to be discharged to the outside of the cell 2,
The solution 7 for which the measurement has been completed can be quickly discharged to the outside of the cell 2, whereby the measurement and analysis work can be performed efficiently.

On the other hand, the compression wave radiated from the crystal oscillator 3 is reflected by the liquid surface of the solution 7, and the reflected wave may enter the crystal oscillator 3 and cause disturbance of vibration.

However, according to the present embodiment, it is possible to prevent such disturbance of the frequency of the crystal oscillator 3 by irregularly reflecting the vibration of the solution by the stirring section 51 of the stirring member 50. , More accurate measurement can be performed.

Further, according to the present embodiment, since the crystal oscillator 3 is provided integrally near the bottom of the cell 2, the crystal oscillator 3 is provided in the housing of the measuring cell as in the prior art. There is no need to dispose the cell, and the space for the cell can be omitted, so that the size of the cell 2 can be reduced.

As described above, according to the present embodiment, it is possible to provide the analyzer 1 having a small and simple configuration capable of efficiently performing measurement and analysis.

FIGS. 3 to 8 show another embodiment of the present invention. Parts corresponding to those of the above-described embodiment are denoted by the same reference numerals, and detailed description thereof will be omitted.

As shown in FIG. 3, the stirring member 50A of the present embodiment is different from the above-described embodiment in that an uneven surface 51a is formed on the surface of the stirring section 51 facing the crystal oscillator 3. It is. In this case, the projections and depressions may be formed on the uneven surface 51a.

According to the present embodiment having such a configuration, since the vibration of the solution 7 can be more irregularly reflected by the uneven surface 51a of the stirring section 51, more accurate measurement can be performed.

As shown in FIG. 4, the stirring member 50B of the present embodiment is different from the above-described embodiment in that the stirring section 51b is inclined at a predetermined angle with respect to the crystal oscillator 3.

According to the present embodiment having such a configuration, the vibration can be more irregularly reflected in the solution 7 by the stirring section 51b of the stirring member 50, so that accurate measurement can be performed.

As shown in FIG. 5, in the analyzer 1A of the present embodiment, a three-way valve 56 composed of an electromagnetic valve is provided in the introduction pipe 55, and the discharge section 9 is connected to the three-way valve 56 via the discharge pipe 57. This embodiment is different from the above embodiment in that it is configured to be connected. Here, the three-way valve 56 is controlled by the control unit 10.

According to the present embodiment having such a configuration, since the solution 7 can be discharged through the stirring member 50, the size of the apparatus can be reduced.

Further, as in the analyzer 1B shown in FIG. 6, a means for supplying the solution 7 is not provided, and the solution 7 can be discharged through the discharge pipe 57 and the stirring member 50. . In this case, the supply of the solution 7 is performed by, for example, a pipette.

According to the present embodiment having such a configuration, the size of the apparatus can be further reduced.

On the other hand, as shown in FIG. 7, in the analyzer 1C of the present embodiment, a plurality (for example, four) of the above-described cells 2 are provided above the analyzer main body 60.

The analyzer 1C includes the oscillator 4 and the frequency counter 5 in the analyzer main body 60, respectively.
It is configured to perform a predetermined process according to an instruction from the computer 6 described above.

In the case of the present embodiment, each cell 2 (2a-2
d) The above-described stirring members 50 (50a to 50d) are mounted thereon, and each of the stirring members 50a to 50d is
3 is configured to be able to move up and down by a driving member 53a.

Each of the stirring members 50a to 50d is connected to a supply section 8 having a pump or the like (not shown) by an inlet pipe 5 respectively.
5a to 55d, so that a predetermined sample and a solution are supplied from the supply unit 8 to each of the cells 2a to 2d.

Each of the cells 2a to 2d is connected to a discharge section 9 having a pump or the like (not shown) via a discharge pipe 61, whereby the solution 7 whose measurement has been completed is transferred to each of the cells 2a to 2d.
d to the discharge section 9.

According to the present embodiment having such a configuration, it is possible to provide an analyzer having a small and simple configuration capable of efficiently measuring and analyzing a large number of sample liquids.

Further, as in an analyzer 1D shown in FIG.
As in the embodiment shown in FIG.
The sample and the solution are supplied from the supply unit 8 to each cell 2a through the 65d.
2d, and the solution 7 can be discharged to the discharge unit 9 through the introduction / discharge pipes 65a to 65d. In this case, it is also possible to adopt a configuration in which the solution 7 is discharged to the discharge unit 9 as in the embodiment shown in FIG.

According to the present embodiment having such a configuration, the size of the apparatus can be further reduced.

The other configurations, functions, and effects of these embodiments are the same as those of the above-described embodiments, and thus detailed description thereof will be omitted.

The present invention is not limited to the above-described embodiment, and various changes can be made. For example, in the above-described embodiment, the liquid is injected into the cell via the stirring member, but the present invention is not limited to this.
For example, it is also possible to adopt a configuration in which a liquid is directly injected into the storage section of the cell body using a pipette.

However, from the viewpoint of miniaturization, it is preferable to inject the liquid into the cell via the stirring member as in the above embodiment.

Further, in the present invention, it is also possible to adopt a construction in which the liquid is directly injected from the inside of the accommodating portion of the cell body. In the case of the present invention, the arrangement and number of cells can be changed as appropriate.

[0084]

As described above, according to the present invention, it is possible to provide a small measuring device and a small analyzing device capable of performing work efficiently.

[Brief description of the drawings]

FIG. 1 is a schematic configuration diagram of an embodiment of an analyzer according to the present invention.

2A is a cross-sectional view of an embodiment of a measuring cell according to the present invention. FIG. 2B is a plan view of a crystal oscillator of the measuring cell. FIG. 2C is a plan view of a crystal oscillator of the measuring cell. Sectional view

FIG. 3 is a cross-sectional view of another embodiment of the present invention.

FIG. 4 is a sectional view of still another embodiment of the present invention.

FIG. 5 is a schematic configuration diagram of still another embodiment of the present invention.

FIG. 6 is a schematic configuration diagram of still another embodiment of the present invention.

FIG. 7 is a schematic configuration diagram of still another embodiment of the present invention.

FIG. 8 is a schematic configuration diagram of still another embodiment of the present invention.

FIG. 9 is a configuration diagram of a conventional analyzer.

FIG. 10 is a graph illustrating a change over time of a resonance frequency of a crystal oscillator used in a conventional analyzer.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... Analysis apparatus 2 ... Cell (measurement cell) 3 ... Crystal oscillator (oscillator) 7 ... Solution (sample liquid) 20 ... Cell body 20a ... Housing part 8 ... Supply part 9 ... Discharge part 50 ... Stirring member 54 ... Inlet hole 55 ... Inlet tube

 ──────────────────────────────────────────────────続 き Continuing from the front page (72) Inventor Fuwa Kochi 2500 Hagizono, Chigasaki-shi, Kanagawa Prefecture Japan Vacuum Engineering Co., Ltd.

Claims (11)

[Claims] 1. A measuring cell having a storage portion for storing a predetermined sample liquid, and a pair of electrodes connectable to a predetermined oscillation source, wherein one of the pair of electrodes is the sample. A measuring device comprising: an oscillator configured to be immersed in a liquid; and a liquid discharging unit for discharging the sample liquid to outside of the measuring cell. 2. A measuring cell having a storage portion for storing a predetermined sample liquid, and a pair of electrodes connectable to a predetermined oscillation source, wherein one of the pair of electrodes is the sample. A measuring device comprising: an oscillator configured to be immersed in a liquid; and a liquid stirring unit for stirring the sample liquid. 3. A measuring cell having a storage section for storing a predetermined sample liquid, and a pair of electrodes connectable to a predetermined oscillation source, wherein one of the pair of electrodes is the sample. A measuring apparatus comprising: an oscillator configured to be immersed in a liquid; and a liquid introduction unit for introducing the sample liquid into a storage unit of the measurement cell. 4. The measuring apparatus according to claim 1, further comprising a liquid stirring section for stirring the sample liquid. 5. The measuring apparatus according to claim 1, further comprising a liquid introduction part for introducing the sample liquid into the accommodation part of the measurement cell. 6. The measurement according to claim 3, further comprising a liquid discharge section for discharging the sample liquid to the outside of the measurement cell, and a liquid stirring section for stirring the sample liquid. apparatus. 7. The liquid agitating unit according to claim 4, wherein the liquid discharging unit is provided in the liquid stirring unit.
The measuring device according to the item. 8. The liquid agitating unit according to claim 5, wherein said liquid introducing unit is provided in said liquid stirring unit.
The measuring device according to the item. 9. The liquid stirring unit according to claim 2, wherein the liquid stirring unit is configured to move in a predetermined direction.
9. The measuring device according to any one of 6, 7, or 8. 10. The measuring apparatus according to claim 1, wherein the oscillator is provided near the bottom of the measuring cell and integrally with the bottom. 11. A measuring device according to claim 1, wherein a plurality of said measuring cells are arranged,
Analysis based on the frequency characteristics of the oscillator immersed in the sample liquid of the predetermined measurement cell, wherein the amount of the component in the liquid that adheres to the oscillator is determined. apparatus.