JP2002253603A - Medical adhesive sheet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medical adhesive sheet which enables quick detection of bacterial breeding in wounds which may occur while it is applied to skin for treatment. SOLUTION: The medical adhesive sheet is provided with a transparent base material 1 made of a silicone and four holding parts 2 formed in circles arranged on one side of the base material. The holding parts 2 are individually impregnated with chemicals which vary in color to an extent enough to perceive it with naked eyes when bacteria begin breeding and the conditions of changes in color differ from one another. The chemicals are, for example, methyl thymol blue, litmus, lead acetate and ferric ions. An adhesive agent is applied to the peripheral part of the base material 1. When the bacteria breed, changes in the chemicals impregnated into the holding parts 2 can be checked through the base material 1 thereby enabling taking of earlier steps for the breeding of the bacteria.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical pressure-sensitive adhesive sheet used as a wound dressing, a bandage, a surgical tape, or another medical patch.

[0002] Medical pressure-sensitive adhesive sheets are widely used in various treatment situations, for example, as bandages. For example, a medical pressure-sensitive adhesive sheet is used when treating a wound such as a shoe slip or other abrasion wound or a burn. Recently, medical pressure-sensitive adhesive sheets have also been used for treating burns caused by laser treatment. In general, such a medical pressure-sensitive adhesive sheet is provided with a pressure-sensitive adhesive layer on a surface of a base material formed in a sheet shape, which is in contact with the skin.

[0003] By the way, the base material of the conventional medical pressure-sensitive adhesive sheet is often opaque. Therefore, the state of the skin cannot be visually recognized in a state where it is attached to the skin. For this reason, in the conventional medical pressure-sensitive adhesive sheet, when the treatment is performed by sticking the pressure-sensitive adhesive sheet, bacteria may grow on the wound surface, and the condition of the wound may be deteriorated.

[0004] In order to prevent such a situation from occurring, generally, the medical pressure-sensitive adhesive sheet is frequently peeled off to check the condition of the wound surface. However, there are cases where this cannot be done. This is remarkable when an occlusive dressing method or a wet dressing method is performed using a medical adhesive sheet. The occlusive dressing method and the wet dressing method refer to a method of treating a wound in a state of being immersed in a body fluid while completely covering the surface of an affected part and keeping the affected part from drying. In conventional wound treatment, dry dressing, in which gauze or the like is applied to the wound, has been the mainstream.However, the occlusive dressing and wet dressing methods promote wound healing more quickly than dry dressing methods and provide a longer healing period. In recent years, it has attracted attention as a method that can shorten the time. Although such a wet dressing method has the potential to shorten the healing period, once the wound is infected with bacteria, the bacteria tend to grow. On the other hand, when bacterial growth occurs, it is necessary to detect it as soon as possible, and perform washing, disinfection, and replacement of the medical adhesive sheet. To realize this, the medical adhesive sheet may be peeled off every predetermined time to check the state of the wound, but this is troublesome. In other words, the occclusive dressing method and the wet dressing method keep the wound stable by extending the time to cover the affected area with the medical adhesive sheet by avoiding the act of `` peeling off the medical adhesive sheet '' as much as possible, It is more convenient to reduce the number of unnecessary wound treatments.

[0005]

SUMMARY OF THE INVENTION The present invention provides a medical pressure-sensitive adhesive sheet which can quickly detect when bacterial growth occurs in a wound when the medical treatment is applied to the skin. The task is to

[0006]

Means for Solving the Problems The present applicant has repeatedly studied to solve such problems. And the following invention was completed. That is, based on a medical pressure-sensitive adhesive sheet, which is provided with a pressure-sensitive adhesive layer for attaching the substrate to the skin on at least a part of the contact surface that is in contact with the skin of the substrate formed in a sheet shape, The base material is configured so that the color of the pressure-sensitive adhesive layer can be confirmed through the base material, and the contact surface is provided with an agent whose color changes to such an extent that the color can be visually recognized when bacteria increase. This is the medical adhesive sheet that has been made. Alternatively, while a medical adhesive sheet having a pressure-sensitive adhesive layer provided on a surface of a base material formed in a sheet shape to be in contact with the skin is basically used, the base material is made of a material having hygroscopicity or moisture permeability. Along with
This is a medical adhesive sheet that is impregnated with a drug that changes its color to the extent that it can be visually recognized when bacteria increase. Any medical adhesive sheet is used by sticking it to the skin. In the former medical pressure-sensitive adhesive sheet, when bacteria grow in a state where the pressure-sensitive adhesive sheet is adhered to the skin, the color of the drug disposed on the substrate in contact with the wound changes. This change in color is made visible through the base material. In the latter medical adhesive sheet, if bacteria grow in a state where it is attached to the skin, the color of the drug impregnated into the base material that comes into contact with the bodily fluid that has leached out of the wound and is absorbed by the base material changes It has become. The change in color is visible to the naked eye as a change in the color of the base material. Therefore, according to such a medical pressure-sensitive adhesive sheet, when bacteria grow in a wound, even a person who does not have specialized medical knowledge can immediately recognize it. Then, when a change in color as described above is recognized, it is only necessary to disinfect the wound or replace the medical adhesive sheet, so that it is possible to quickly cope with the case where bacteria grow when using the medical adhesive sheet. become. In other words, unless the color of the drug changes,
Since the possibility of bacterial infection is low, the medical adhesive sheet can be stuck to the affected part as long as possible.

[0007] The substrate in the former invention may be any substrate as long as the color of the pressure-sensitive adhesive layer can be confirmed through the substrate. The substrate can be made of, for example, a transparent or translucent (including both colorless and transparent) colored material. Further, even if the pressure-sensitive adhesive layer is formed of an opaque material, the color of the pressure-sensitive adhesive layer can be confirmed by forming the layer in a mesh shape, for example.

[0008] The substrate in the former invention may be moisture-permeable or moisture-impermeable. When the substrate is made of moisture-impermeable material, the medical adhesive sheet is
It is suitable for the above-mentioned wet dressing method.

The substrate in the former invention may be made of any material as long as the color of the pressure-sensitive adhesive layer can be confirmed through the substrate. For example, the substrate can be made of resin. When the substrate is transparent or translucent, the substrate can be made of a resin. Further, even when the base material is made to be impermeable, it can be constituted by a resin.

The substrate in the latter invention may be any material as long as it is made of a material having moisture absorption or moisture permeability. Of course, it may have both moisture absorption and moisture permeability. The material of the substrate may be any material as long as it satisfies the above-mentioned conditions. For example, it can be made of cloth (including both woven cloth and non-woven cloth) or paper.

[0011] In the former invention, the above-mentioned drug which informs the growth of bacteria by a color change that can be visually recognized is used in the former invention.
It is arranged on at least a part of the surface of the substrate that is in contact with the skin. This agent may be arranged in a range different from that of the adhesive layer, or may be mixed in the adhesive layer. Further, a holding means for holding the medicine may be provided on the contact surface. In this case, the medicine is disposed on the contact surface of the equipment in a state of being impregnated in the holding means. In the case of the latter invention,
The drug is impregnated into the substrate. In this case, the drug may be impregnated into the entire substrate, or may be impregnated only in a predetermined area of the substrate.

The drug in the present invention may be a single drug or may include a plurality of drugs whose colors change under different conditions. In that case, the pH described below
Detecting agents, hydrogen sulfide detecting agents, and other agents can be used in appropriate combination. In the case where a plurality of types of drugs are contained and, in the former invention, the drugs are mixed in the pressure-sensitive adhesive layer, the plurality of types of drugs may be mixed in different portions of the pressure-sensitive adhesive layer. In the case where a plurality of types of drugs are included, and in the former invention, when the drugs are impregnated in the holding means, the plurality of types of drugs may be impregnated in different portions of the holding means. In the case of the latter invention in which a plurality of types of drugs are contained, the plurality of types of drugs may be impregnated in different portions of the base material. The drug in the present invention may be any drug as long as its color changes to such an extent that it can be visually recognized when bacteria increase. For example, a pH detecting agent whose color changes to such an extent that it can be visually recognized when the pH changes from neutral to acidic can be used as the agent of the present invention. This drug utilizes the property that human body fluids are essentially neutral in nature, but when bacteria grow, they become acidic. The pH detecting agent is not limited to this, but it suffices if the color changes between the acidic pH and the neutral pH so that the color can be discerned by the naked eye. More specifically, examples of such a pH detecting agent include indigo carmine, Nile blue, methyl red, phenol phthalein, congo red, brom cresol green, brom phenol red, and brom thymol blue. , Cresol Red, Thymol Blue,
Any one of brom phenol blue, tetra brom phenol red, brom cresol purple, alizarin yellow, aniline blue, litmus, andrade, and neutral red can be used.
Of course, two or more of these may be used.
In addition, a drug whose color changes to a degree that can be discerned by the naked eye between a pH of 3 or more and a pH of 3 or less can more accurately capture bacterial growth. For example, Timor
Blue, phenol blue and phenol red correspond to this. In addition to the pH detector, a hydrogen sulfide detector that changes its color to the extent that it can be recognized by the naked eye when reacted with hydrogen sulfide can be used as the above agent. This utilizes the property that hydrogen sulfide is generated when bacteria grow. As the hydrogen sulfide detector, for example, at least one of lead acetate and ferric ion can be used. There are many other tests to detect bacteria. Among the agents for performing these, those whose color changes to such an extent that they can be discerned by the naked eye when bacteria increase, can be used as the agent of the present invention. The drug of the present invention may also contain an auxiliary drug useful for causing the drug to change color.
For example, when performing a phenylalanine deaminase test as the test described above, phenylalanine can be used as an auxiliary drug. The phenylalanine deaminase test is a test in which bacteria deaminate phenylalanine by an enzymatic reaction to produce phenylpyruvic acid and thereby become acidic. In this case, phenylalanine, which acts as an aid for causing a color change of the pH detector due to a change in acidity to pH, corresponds to the above-mentioned auxiliary agent. Other examples of the above-mentioned tests include a phosphatase test, an oxidative fermentation test, a methylene blue milk reduction test, a malonate test, and a litmus milk test. The phosphatase test is a production test of phosphatase that cleaves phenolphthalein diphosphate, and mainly detects the growth of staphylococci and Escherichia coli by releasing phenolphthalein and turning orange-pink. The oxidative fermentation test shows that the pH changes to acidic due to the presence of metabolites that have been oxidized or fermented by the utilization of sugar by bacteria.
It is detected by an H detecting agent. As a drug, Prussian blue, bromcresol, purple, or the like is used. The methylene blue milk reduction test examines bacteria by a change in the activity of an enzyme that reduces methylene blue in a medium mixed with milk.

[0013]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Medical adhesive sheets according to preferred first and second embodiments of the present invention will be described below.

First Embodiment A medical pressure-sensitive adhesive sheet according to this embodiment has a pressure-sensitive adhesive layer formed by applying a pressure-sensitive adhesive to a predetermined portion of the back surface (surface in contact with the skin) of a substrate formed in a sheet shape. Is the basic configuration.

The substrate of the pressure-sensitive adhesive sheet for medical use in this embodiment is, for example, colored or colorless, transparent or translucent. The transparency only needs to be such that the skin can be seen when the medical adhesive sheet is attached to the skin, but in this example, it is colorless and transparent. Various materials can be considered as the material of the base material. Various resins and rubbers, for example, silicone, tetron, acrylic, cellophane,
By combining one or more of fluororesin, ionomer, nylon, polycarbonate, polyester, polyethylene, polypropylene, polystyrene, polyurethane, polyvinyl alcohol, polyvinylidene chloride, polyvinyl chloride, vinyl acetate, hydrochloric acid rubber, vinyl chloride, etc. This base material can be constituted. Also,
Depending on the purpose, secondary processing such as coating processing and corona processing may be performed. When the medical pressure-sensitive adhesive sheet is applied to an occlusive dressing method or a wet dressing method, the base material is impermeable to moisture. It is possible to obtain the degree of moisture impermeability required for the occlusive dressing method and the wet dressing method by using the above-mentioned materials by appropriately setting the thickness of the base material and the like. In this example, silicone or polyurethane is used as the material, and the thickness is set to 0.2 mm to constitute the base material.

The pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet for medical use in this embodiment may be applied to a predetermined portion on the back surface of the substrate as described above. It may be applied to the entire surface of the back surface of the base material, or may be applied to a part thereof, for example, only to a portion that does not come into contact with the wound. The medical adhesive sheet in this embodiment is applied to the entire back surface of the substrate. The pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer may be of any type as long as the substrate can be stuck to the skin for a long time. What is necessary is just to select suitably within the range which does not have a bad influence on skin. As the pressure-sensitive adhesive, for example, an acrylic pressure-sensitive adhesive “SK Dyne MD-1” manufactured by Soken Chemical Co., Ltd. can be used. In addition to this, an aluminum chelate crosslinking agent “M-5” manufactured by Soken Chemical Co., Ltd. as a crosslinking agent
A "or the like may be appropriately added. In forming the pressure-sensitive adhesive layer on the back surface of the substrate, any method may be used. For example, a transfer method can be used. In the transfer method in this case, for example, polyethylene laminate release paper can be used. As the release paper, for example, a paper obtained by thermally fusing a polyethylene layer to a thickness of about 15 μm on high-quality paper, applying a release agent containing a silicone resin as a main component to the polyethylene layer, and drying can be used.

The pressure-sensitive adhesive contains a drug whose color changes to such an extent that it can be visually recognized when bacteria increase. The pressure-sensitive adhesive of this example contains a pH detecting agent whose color changes to such an extent that it can be discerned by the naked eye when the pH changes from neutral to acidic. The amount may be set to such an amount that the change in color can be identified with the naked eye. The amount may be appropriately selected according to the type of the pH detecting agent.
As the pH detecting agent, for example, an agent whose color changes to an extent that the color can be discerned by the naked eye when the pH is acidic and when the pH is neutral can be used. For example, but not limited to, brom thymol blue can be used as the pH detector. Alternatively, a color whose color changes to an extent that can be recognized by the naked eye when the pH is around 3.5, for example, when the color is 2 and 4 when the color can be visually identified. Can be used as a pH detecting agent. For example, thymol blue and phenol
At least one of the blues can be used for this.
By applying a mixture of a pH detecting agent to the above-mentioned adhesive and applying the above-described transfer method to the back surface of the base material, an adhesive layer containing the pH detecting agent is formed on the back surface of the base material. be able to. Instead of the pH detector, a hydrogen sulfide detector whose color changes to such an extent that it can be recognized by the naked eye when reacted with hydrogen sulfide may be mixed into the adhesive. For example, at least one of lead acetate and ferric ion can be mixed with the adhesive and applied to the back surface of the base material using a transfer method. An auxiliary medicine may be mixed with the above-mentioned medicine. For example, thymol blue as a pH detector,
Phenylalanine as an auxiliary agent can be mixed. In this case, the phenylalanine deaminase test is performed when the medical adhesive sheet is used. Further, an auxiliary drug useful for causing a change in color may be mixed with the drug. For example, when performing a phenylalanine deaminase test as the test described above, phenylalanine can be used as an auxiliary drug. The phenylalanine deaminase test is a test in which bacteria deaminate phenylalanine by an enzymatic reaction to produce phenylpyruvic acid and thereby become acidic. In this case, p to acidity
Phenylalanine, which serves as an aid for causing a color change of the pH detecting agent due to an H change, corresponds to the above-mentioned auxiliary agent. The drug may also be applied to the substrate in such a way that different types are mixed in each part of the adhesive. For example, by repeatedly performing the above-described transfer method, it becomes possible to distribute different types of drugs to each part of the adhesive. In this case, it is assumed that the colors of the plurality of types of drugs change under different conditions.
For example, phenol blue may be arranged in one part and ferric ion may be arranged in another part.

This medical pressure-sensitive adhesive sheet is used by attaching the back surface to the skin so that the wound is hidden, as in the case of a normal medical pressure-sensitive adhesive sheet. If bacterial growth occurs in the wound, the pH detector or hydrogen sulfide detector changes color. Since the change in color can be visually observed through the base material, when the change in color is noticed, the medical adhesive sheet may be peeled off, and the medical treatment may be changed or an appropriate treatment may be performed.

In the first embodiment, the agent is mixed with the pressure-sensitive adhesive disposed on the contact surface of the base material. However, the following modifications are also conceivable.

That is, a holding portion for holding the medicine is provided on the contact surface of the base material. This holding portion corresponds to the holding means of the present invention, and is capable of holding a medicine in a state in which the medicine is impregnated. For example, this can be constituted by paper or cloth. The holding portion arranged on the contact surface of the base material may have any shape, and its arrangement is also free. For example, it can be as shown in FIGS. FIG. 1 to FIG.
FIG. 2 is a perspective view showing the base material 1 as viewed from its contact surface side. In the example shown in FIG. 1, a holding unit 2 formed by forming a filter paper in a circular shape is arranged in a rectangular shape on a contact surface of a base material 1 formed in a rectangular shape. Each holding part 2 is impregnated with a medicine whose color changes under different conditions. In the example shown in FIG. 2, a holding unit 2 formed of a cloth in a tape shape is arranged in a lattice shape on a contact surface of a base material 1 formed in a rectangular shape. Each holding part 2 is impregnated with a medicine whose color changes under different conditions. In the example shown in FIG. 3, a holding portion 2 made of two filter papers formed so that the base material is exposed in a circular shape is arranged on the contact surface of the base material 1 formed in a rectangular shape. Each holding part 2 is impregnated with a medicine whose color changes under different conditions. Although not shown, the medical adhesive sheet shown in FIGS. 1 to 3 has an adhesive applied to a portion where the substrate 1 is exposed, provided around the contact surface. I have. Further, the same material as described above is used for the material of the base material 1 and the composition of the pressure-sensitive adhesive in each medical pressure-sensitive adhesive sheet.

{Second Embodiment} Similarly to the first embodiment, the medical pressure-sensitive adhesive sheet of this embodiment has a predetermined portion on the back surface (surface in contact with the skin) of a sheet-shaped base material. The basic configuration is that in which an adhesive is applied to form an adhesive layer.

The difference is the material of the base material. The base material of the medical pressure-sensitive adhesive sheet is supposed to have moisture permeability and hygroscopicity, and is made of cloth or paper. Specifically, it is made of woven gauze. Although not necessary, the surface of the gauze is covered with a transparent resin. The same adhesive as in the first embodiment can be used as the adhesive constituting the adhesive layer. Further, in this embodiment, the pressure-sensitive adhesive layer is formed only on the peripheral portion of the base material. By making the transparent resin layer wider than the gauze, the transparent resin layer protrudes from the outer periphery of the gauze, and the adhesive layer can be formed only on the back surface of the resin at the protruding portion. In the pressure-sensitive adhesive of the medical pressure-sensitive adhesive sheet of the second embodiment,
It is not necessary to incorporate a drug that changes its color to the extent that it can be visually identified when bacteria increase. In the medical pressure-sensitive adhesive sheet of this example, instead, gauze as a base material is impregnated with such a drug. As this medicine, the same medicine as in the first embodiment can be used. That is, the base material of the medical adhesive sheet is impregnated with a pH detecting agent or a hydrogen sulfide detecting agent. Each part of the gauze can be impregnated with an agent whose color changes under different conditions.

The medical adhesive sheet of the second embodiment is used in the same manner as the conventional adhesive sheet. If bacterial growth occurs in the wound, the pH detector or hydrogen sulfide detector changes color. This change in color can be visually observed as a change in the color of the base material. Therefore, when the change in color is noticed, the medical adhesive sheet may be peeled off, and the medical treatment may be changed and appropriate treatment may be performed.

[0024]

The medical pressure-sensitive adhesive sheet according to the present invention as described above can detect bacterial infection when bacterial growth occurs in a wound while being applied to the skin for treatment. Becomes

[Brief description of the drawings]

FIG. 1 is a perspective view showing an example of a medical adhesive sheet according to an embodiment of the present invention.

FIG. 2 is a perspective view showing an example of a medical adhesive sheet according to another embodiment of the present invention.

FIG. 3 is a perspective view showing an example of a medical pressure-sensitive adhesive sheet according to still another embodiment of the present invention.

[Explanation of symbols]

 1 base material 2 holding part

Claims (18)

[Claims] 1. A medical pressure-sensitive adhesive sheet comprising a sheet-shaped substrate and a pressure-sensitive adhesive layer provided on at least a part of an abutting surface of the substrate for contacting the skin, the pressure-sensitive adhesive layer being applied to the skin. The base material is configured so that the color of the drug can be confirmed through the base material, and the contact surface is provided with a drug that changes its color to the extent that it can be visually identified when bacteria increase. A medical pressure-sensitive adhesive sheet, comprising: 2. A medical pressure-sensitive adhesive sheet in which a pressure-sensitive adhesive layer is provided on a surface of a base material formed in a sheet shape to be in contact with skin, wherein the base material is made of a material having hygroscopicity or moisture permeability. A medical pressure-sensitive adhesive sheet characterized by being impregnated with a drug whose color changes to such an extent that it can be visually identified when bacteria increase. 3. The medical pressure-sensitive adhesive sheet according to claim 1, wherein the drug is mixed in the pressure-sensitive adhesive layer. 4. The medical adhesive sheet according to claim 1, wherein holding means for holding the medicine is provided on the contact surface, and the medicine is impregnated in the holding means. 5. The medical adhesive sheet according to claim 1, wherein the medicine includes a plurality of kinds of medicines whose colors change under different conditions. 6. The medicine is a plurality of kinds of medicines whose colors change under different conditions, and the plurality of kinds of medicines are:
The medical pressure-sensitive adhesive sheet according to claim 1, wherein the pressure-sensitive adhesive sheet is mixed with different portions of the pressure-sensitive adhesive layer. 7. The medicine is a plurality of kinds of medicines whose colors change under different conditions, and the plurality of kinds of medicines are:
The medical pressure-sensitive adhesive sheet according to claim 4, wherein different parts of the holding means are impregnated. 8. The medicine is a plurality of kinds of medicines whose colors change under different conditions, and the plurality of kinds of medicines are:
The medical pressure-sensitive adhesive sheet according to claim 2, wherein different parts of the substrate are impregnated. 9. The medical pressure-sensitive adhesive sheet according to claim 1, wherein the substrate is made of a transparent or translucent material. 10. The medical pressure-sensitive adhesive sheet according to claim 1, wherein the base material is impermeable to moisture. 11. The medical adhesive sheet according to claim 1, wherein the substrate is made of a resin. 12. The medical adhesive sheet according to claim 2, wherein the substrate is made of cloth or paper. 13. The medical pressure-sensitive adhesive sheet according to claim 1, wherein the drug is a pH detecting agent whose color changes to such an extent that it can be visually recognized when the pH changes from neutral to acidic. 14. The pH detecting agent according to claim 13, wherein the color of the pH detecting agent changes to such an extent that it can be discerned by the naked eye when the pH is acidic and when the pH is neutral. Medical adhesive sheet. 15. The pH detecting agent may be indigo carmine, Nile blue, methyl red, phenol phthalein, Congo red, brom cresol green, brom phenol red, brom thymol blue, cresol.・ Red, Timor Blue,
The composition according to claim 1, comprising at least one of brom phenol blue, tetra brom phenol red, brom cresol purple, alizarin yellow, aniline blue, litmus, andrade, and neutral red. Medical adhesive sheet. 16. The medical pressure-sensitive adhesive sheet according to claim 1, wherein the agent is a hydrogen sulfide detection agent whose color changes to such an extent that it can be visually recognized when reacted with hydrogen sulfide. 17. The medical adhesive sheet according to claim 16, wherein the hydrogen sulfide detecting agent is at least one of lead acetate and ferric ion. 18. The medical adhesive sheet according to claim 1, wherein the medicine is mixed with an auxiliary medicine useful for causing the medicine to change color.