JP2002200111A - Poultice - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a poultice capable of imparting low irritating capacity at the time of peeling after pasting, repeating pasting capacity enabling twice pasting, rash-resistant capacity hard to generate rash in long-time pasting, waterproof capacity capable of inhibiting the penetration of water from a pasting interface, highly air permeable capacity preventing the stuffiness or sore of a pasted part and water absorbable capacity rapidly absorbing body fluids to protect the affected part from various bacteria. SOLUTION: The poultice is obtained by providing a soft and viscous pressure-sensitive agent layer, which contains a polymer soft and viscous agent selected from an alkylacrylic ester copolymer having a functional group, alkyl fatty acid ester and oily substances containing alkyl fatty acid ester and a crosslinking agent selected from epoxy, a metal chelate, isocyanate, melamine, ethylenimine and ethylenethiourea, on the single surface or both surfaces of a support and has low irritating capacity not damaging the horny layer on the surface of the skin at the time of peeling after pasting, repeating pasting capacity enabling twice pasting and rash-resistant capacity hard to generate resh in long-time pasting.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel patch mainly used for preventing skin damage and protecting a wound, and for fixing a body fluid absorbing material and a material for treating a wound. More specifically, the present invention is intended for applications requiring low irritation to the skin surface at the time of peeling, applications requiring two-time application, applications requiring less fogging even for long-time application, and waterproofing. The present invention relates to a novel patch which is suitably used for applications requiring high air permeability, applications requiring high air permeability, and applications requiring water absorption.

[0002]

2. Description of the Related Art Conventionally, prevention of skin damage and protection of wounds,
Further, an acrylic adhesive or a rubber adhesive is usually used as an adhesive of a patch used for fixing a body fluid absorbing material or a wound treatment material. However, all of these pressure-sensitive adhesives have strong adhesion to the skin, and some problems have been pointed out depending on the intended use. For example,
In the case of a patch for infants or the like, a part of the stratum corneum on the skin surface is peeled off at the time of peeling after the patch is applied, which often causes pain and itching. In a busy medical setting, a patch temporarily fixed on the skin is once again attached to the affected area, but when the patch is temporarily removed, the stratum corneum of the skin is adhered to the adhesive surface of the patch. As a result of the adhesion, there is a problem that the adhesive strength is lost and it is impossible to apply the adhesive twice. Furthermore, in cases such as when long-term application is required, the adhesive strength of the adhesive patch is too strong, and rash is likely to occur due to physical (mechanical) skin irritation due to the tension between the adhesive patch edge surface and the skin. The problem has been pointed out. Furthermore, in applications requiring waterproofness, the above-mentioned conventional pressure-sensitive adhesive has a large cohesive force, and does not easily penetrate into the skin sulcus at the time of application, thereby allowing water to enter from the application interface. Shortcomings have been noted. Also, in applications requiring high air permeability, it is not enough to provide the support with air permeability,
The pressure-sensitive adhesive layer also needs to have air permeability, and the wire is coated with the pressure-sensitive adhesive. However, in this method, since the area occupied by the pressure-sensitive adhesive is naturally reduced, the normal pressure-sensitive adhesive having poor adhesion to the skin is used. Then, there is a problem that the adherend cannot follow the movement of the adherend and immediately peels off. In addition, acrylic adhesives and rubber adhesives have poor water absorption and cannot be used for applications that must absorb body fluids and the like.

[0003] On the other hand, plaster layers (pressure-sensitive adhesive layers) which have reduced these drawbacks have been proposed for drug-containing protective pads and drug-containing patches. For example, JP-A-61-2499
No. 34 and JP-A-62-53933, dermatological administration containing an alcohol having 1 to 5 carbon atoms, an alcohol having 7 to 20 carbon atoms, an aliphatic carboxylic acid and the like for the purpose of enhancing transdermal absorption of a drug. Compositions have been proposed.

Japanese Patent Application Laid-Open No. 61-186316 discloses a drug, a water-soluble protein exhibiting an absorption promoting action, a polyhydric alcohol imparting softness, a tackifier, and an oily substance promoting percutaneous absorption. A soft external patch is disclosed.

Further, Japanese Patent Application Laid-Open No. 4-368322 discloses that a blend polymer of a vinylpyrrolidone (co) polymer and a (meth) acrylic acid copolymer is used as a main component, to which a polyhydric alcohol is used as a softener, and that a tackifier is provided. A medical adhesive to which rosin is added as an agent has been proposed.

Further, Japanese Patent Application Laid-Open No. 4-325525 discloses that on one side of a support, a drug, a water-insoluble pressure-sensitive adhesive, a polyhydric alcohol, and silicic acid anhydride and, if necessary, a compound having a plasticizing action to the pressure-sensitive adhesive. plasters plaster layer is provided comprising is disclosed.

[0007]

However, in the techniques disclosed in JP-A-61-249934 and JP-A-62-53933, a lower alcohol which promotes drug permeability and softens the plaster is used. However, if the plaster layer of the patch with the support contains a lower alcohol amount sufficient to promote the drug permeation, the plaster layer becomes too soft and the skin is removed when the plaster is peeled from the skin. There are problems such as adhesive residue on the top and an extremely low adhesive strength of the plaster.

Further, in the method disclosed in JP-A-61-186316 and JP-A-4-368322 in which a polyhydric alcohol is used as a softening agent for imparting softness to an adhesive (plaster layer). Indeed, the pressure-sensitive adhesive (plaster layer) can be given flexibility and a fit to the skin etc. can be obtained, but it is difficult to maintain the cohesive force and adhesive strength of the pressure-sensitive adhesive (paste layer). This poses a problem that it is difficult to fix / fix to the skin or the like by itself.

Further, in Japanese Patent Application Laid-Open No. 4-325525, silicic anhydride is added to a pressure-sensitive adhesive together with a polyhydric alcohol or a plasticizing compound for the purpose of suppressing the flowability of the pressure-sensitive adhesive by increasing the cohesive force of the water-insoluble pressure-sensitive adhesive. Although it is added,
Addition of silicic anhydride has a problem that it is difficult to disperse the adhesive in the pressure-sensitive adhesive and leads to non-uniformity of the pressure-sensitive adhesive.

The present invention has been made in order to solve the above-mentioned drawbacks of the prior art, and an object of the present invention is to provide a soft and soft adhesive which has good adhesive properties and can be fixed and fixed to the skin with no adhesive residue. Using a viscous adhesive, low irritation performance in peeling after application, repeated application performance that can be applied twice, anti-fogging performance that is resistant to fogging in long-time application, waterproof performance that can prevent water from entering the application interface, application It is an object of the present invention to obtain a patch which can impart high air-permeability to prevent stuffiness and swelling of a part, and water-absorbing ability to quickly absorb a body fluid and protect an affected part from various bacteria.

[0011]

DISCLOSURE OF THE INVENTION The present invention relates to an alkyl acrylate copolymer having a functional group, a polymer softener selected from fatty acid alkyl esters or oils containing fatty acid alkyl esters, and epoxy and metal chelates. Isocyanate, melamine, ethyleneimine or ethylene thiourea a soft viscous pressure-sensitive adhesive layer containing a cross-linking agent selected from the group consisting of provided on one or both sides of the support, peeling the horny layer of the skin surface after application It is a patch that has low irritation performance that does not hurt, repeat application performance that can be applied twice, and anti-fogging performance that is resistant to fogging even when applied for a long time.

In a preferred embodiment of the patch of the present invention, the soft viscous adhesive contains 85 to 50% by weight of solid content of the alkyl acrylate copolymer and 15 to 30% by weight of the polymer soft adhesive as an active ingredient. 0.25 to 10.0% by weight of the crosslinking agent as an active ingredient, and wherein the soft viscous adhesive is at least one selected from an acrylic polymer, a graft starch polymer, and a cellulose polymer. Two hydrophilic polymer substances are further contained at a solid content ratio of 99/1 to 70/30 (alkyl acrylate copolymer / hydrophilic polymer substance) with respect to the alkyl acrylate copolymer. .

In a preferred embodiment of the patch of the present invention, the patch is a patch wherein the pad is attached to the soft adhesive layer, so that the soft adhesive layer protrudes at least 5 mm outside the outer edge of the pad. I do. In a further preferred embodiment of the patch of the present invention, the pad is carboxyvinyl polymer, polysaccharides, containing at least one material selected from cellulose, and polyvinyl alcohol.

In a preferred embodiment of the patch of the present invention, the support comprises a monolayer or a laminate of a film, a woven fabric, a knitted fabric, a nonwoven fabric, a paper, or a laminate of a combination of two or more of these. Further in a preferred embodiment of the patch of the present invention,
The support is obtained by thermocompressing a woven or knitted fabric on one side of a film, and the soft viscous adhesive is applied on the woven or knitted fabric at a thickness such that the woven or knitted fabric is not exposed to the surface layer. Is provided.

In a preferred embodiment of the patch of the present invention, the soft viscous pressure-sensitive adhesive layer provided on one side or both sides of the support has a substantially non-adhesive portion having a desired shape at a desired position.

[0016]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail with reference to the drawings. FIG. 1 is a perspective view of a roll-shaped patch of the present invention, FIG. 2 is a partially cutaway perspective view of a strip-shaped patch of the present invention, and FIG. 3 is provided with a pad on a soft viscous adhesive layer. FIG. 4 is a perspective view of a patch of the present invention in a shape, and FIG. 4 is a partially cutaway perspective view of the patch of the present invention comprising a support having a two-layer structure of a film and a knitted fabric and a soft viscous adhesive. FIG. 1 is a partially cutaway perspective view of the patch of the present invention having a substantially non-adhesive pattern in a soft viscous adhesive layer. Among the symbols in the figure,
1 is the patch of the present invention, 2 is a support, 2a is a film, 2b
Is a knitted cloth (woven cloth), 3 is a soft viscous adhesive (layer), 4 is a core tube,
Reference numeral 5 denotes release paper, 6 denotes a pad, 6a denotes a pad outer edge, and 7 denotes a pattern.

The patch of the present invention is, as described above, a polymer softener selected from alkyl acrylate copolymers having a functional group, fatty acid alkyl esters or oils containing fatty acid alkyl esters, epoxies, metal chelates. , A soft viscous pressure-sensitive adhesive containing a crosslinking agent selected from isocyanate, melamine, ethyleneimine, and ethylenethiourea is provided on one surface or both surfaces of a support. The patch of the present invention can take any shape as long as such a configuration is adopted. For example, the patch can take a roll shape as shown in FIG. 1 or a strip shape as shown in FIGS. In the drawings, only the case where the soft viscous adhesive 3 is provided on one surface of the support 2 is illustrated, but if necessary, the soft viscous adhesive 3 may be provided on both surfaces of the support 2.

The alkyl acrylate copolymer having a functional group constituting the soft viscous adhesive of the patch of the present invention may be a copolymer of an alkyl acrylate and a functional monomer or a copolymer of an alkyl acrylate and a functional monomer. And a copolymer of a hydrophilic monomer and a third component. Examples of the above-mentioned alkyl acrylate include alkyl acrylates having an alkyl group having 1 to 18 carbon atoms, such as butyl acrylate, isobutyl acrylate, hexyl acrylate, octyl acrylate, 2-ethylhexyl acrylate, Isooctyl acrylate, decyl acrylate, isodecyl acrylate, lauryl acrylate, stearyl acrylate, methyl methacrylate,
Examples thereof include one or a combination of two or more of ethyl methacrylate, butyl methacrylate, isodecyl methacrylate, lauryl methacrylate, stearyl methacrylate, and the like.

Examples of the functional monomer copolymerizable with the above-mentioned alkyl acrylate include monomers having a functional group such as a carboxyl group, an amino group, an amide group and a hydroxyl group. Examples of monomers having a carboxyl group include maleic acid, acrylic acid, methacrylic acid, unsaturated carboxylic acids such as itaconic acid, maleic acid monoalkyl esters such as butyl maleate, fumaric acid,
Crotonic acid and the like.

[0020] As a monomer having an amino group, dimethylaminoethyl acrylate, and vinyl pyrrolidone. Examples of the monomer having an amide group include alkyl acrylamides such as acrylamide, dimethyl acrylamide and diethyl acrylamide, alkyl ether methylol acrylamides such as butoxymethyl acrylamide and ethoxymethyl acrylamide, and diacetone acrylamide.

Examples of the monomer having a hydroxyl group include hydroxyalkyl acrylates such as 2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, hydroxypropyl acrylate and hydroxypropyl methacrylate.

Examples of the third component copolymerizable with the above-mentioned alkyl acrylate include ethylene, propylene, butadiene, acrylonitrile, vinyl acetate, vinyl alcohol, styrene, α-methylstyrene, and vinyl chloride.

The content of the functional monomer capable of copolymerizing with the alkyl acrylate of the above-mentioned alkyl acrylate copolymer is preferably in the range of 0.2 to 20 mol%. The reason is that if the amount is less than 0.2 mol%, it is difficult to obtain the effect as a crosslinking point, and as a result, even if a crosslinking agent is added and reacted, it is difficult to obtain sufficient crosslinking in the pressure-sensitive adhesive, If the amount is more than 20 mol%, there is a possibility that a problem such as that the pressure-sensitive adhesive to which the cross-linking agent is added easily gels during the steps of blending and coating may occur. The content of the third component copolymerizable with the above-mentioned alkyl acrylate is preferably in the range of 0 to 50 mol%.

The polymer softener constituting the soft viscous pressure-sensitive adhesive of the patch of the present invention is selected from fatty acid alkyl esters or oils containing fatty acid alkyl esters. Examples of the fatty acid alkyl ester include diisopropyl adipate, dioctyl adipate, hexadecyl dioctoate, ethyl oleate, diglyceride oleate, triglyceride oleate, decyl oleate, cecil octanoate, diglyceride caprylate, triglyceride caprylate, and diglyceride caprate. , Capric triglyceride, mixed acid triglyceride consisting of caprylic acid and capric acid, dioctyl succinate, sucrose fatty acid ester, butyl stearate, octyl stearate, octyl hydroxystearate, diethyl sebacate, triacetin, isopropyl palmitate, palmitin Octyl acid, sorbitan monopalmitate, isopropyl myristate, octyl dodecyl myristate, milli myristate Chill, hexyl laurate, linoleic acid diglyceride, and the like mixed acid groups triglycerides consisting of linoleic acid and oleic acid.

[0025] as an oily compound containing the fatty acid alkyl esters, lard, mutton tallow, beef tallow, animal fats such as spermaceti, soybean oil, sesame oil, cottonseed oil, coconut oil, olive oil, castor oil, such as vegetable oils beeswax, etc. Is mentioned.

The crosslinking agent constituting the soft adhesive of the patch of the present invention is selected from epoxy, metal chelates such as aluminum, isocyanate, melamine, ethyleneimine, and ethylenethiourea.

If necessary, a hydrophilic polymer substance comprising one or more of an acrylic polymer, a graft starch polymer and a cellulose polymer is added to the soft viscous adhesive of the patch of the present invention. Among these hydrophilic polymer substances,
Examples of the acrylic polymer include polyacrylic acid, polymethacrylic acid, polyacrylate crosslinked polymer, diacrylate crosslinked polymer, acryl-vinyl acetate saponified copolymer, polyacrylonitrile graft polymer, and the like. Examples of the starch-based polymer include starch-vinyl sulfonic acid graft polymer, cellulose-styrene sulfonic acid graft polymer, starch-vinyl sulfonic acid graft polymer, and the like, and the cellulose-based polymer includes cellulose-acrylonitrile graft polymer. Coalesce, cellulose-styrene sulfonic acid graft polymer, carboxymethyl cellulose cross-linked polymer and the like. In addition, as the hydrophilic polymer in the case where co-crosslinking is required with the above-mentioned alkyl acrylate copolymer, among the above-mentioned polymers, those used in the alkyl acrylate copolymer used simultaneously are used. It is desirable to select a hydrophilic polymer substance having a functional group.

In these hydrophilic macromolecular substances, a pharmaceutical active ingredient such as a drug or a physiologically active substance that irritates a living body can be blended, kneaded, impregnated, or mixed. Pharmaceutical active ingredients used in these hydrophilic polymer substances are not particularly limited, and include, for example, antiinflammatory agents containing steroids such as triamcinolone acetonide, halcinonide, betamethasone valerate, hydrocortisone, tipredan, and anti-inflammatory. Analgesics and antipruritics, non-steroidal drugs such as bufexamac, aspirin, ketoprofen, indomethacin, flurbiprofen, anti-psoriatic agents such as dithranol, coal tar extract, keratolytics such as salicylic acid, methyl salicylate, urea, Local anesthetics such as lidocaine and benzocaine, antibacterial agents such as benzalkonium chloride, benzethonium chloride, alkyldiaminoethylglycine hydrochloride, chlorhexidine gluconate, sodium hypochlorite, fusidic acid, nystatin, disulano , Amphotericin, econazole and other antifungal and antiviral agents, benzoyl peroxide, anti-anemic agents such as vitamin A derivatives, uroxanases, biologically active agents such as tissue plasminogen activator, fibrinolytic enzymes, proteins Enzymes such as decomposing enzymes, mint oil, menthol, vanillyl amide nonanoic acid (capsaicin), camphor, vitamins, and other medicinal agents such as herbal medicines are appropriately selected and used depending on the application.

The soft viscous pressure-sensitive adhesive used in the patch of the present invention comprises a functional group-containing alkyl acrylate-based copolymer which absorbs water but does not dissolve in water as a base polymer and has a solid content of 85 to 50% by weight. %, And a polymer softener selected from fatty acids or oils containing fatty acid alkyl esters that imparts a soft viscosity to the acrylic acid alkyl ester-based copolymer, as an active ingredient, 15 to 30% by weight of the polymer. a crosslinking agent to enhance the cohesive strength containing 0.25 to 10.0 wt% active ingredient. The base polymer used here is required to absorb water but not dissolve in water,
The reason is that the base polymer having a large deliquescent has a disadvantage that it loses cohesive force due to the inclusion of water and sticks to the skin to cause glue residue.
This is because a base polymer that accounts for more than 30% is required. On the other hand, the reason why the use amount of these alkyl acrylate copolymers is 85 to 50% by weight of the total solids is that the amount of the alkyl acrylate copolymer is 85%.
If the amount is more than 10% by weight, the amount of the polymer softening agent to be added is relatively too small to give the pressure-sensitive adhesive a necessary and sufficient soft viscosity. If the amount is less than 50% by weight, the amount of other additional components becomes relatively large, and the cohesive force and adhesive force required for the soft adhesive cannot be imparted. It is also not preferable from the viewpoint of the efficiency of polymer crosslinking that increases cohesion.

The polymer softener is used for the purpose of imparting soft viscosity to the base polymer. The reason why the amount used is 15 to 30% by weight of the total solid is that if the amount is less than 15% by weight, This is because sufficient soft viscosity cannot be imparted to the base polymer to be used. If the amount exceeds 30% by weight, the polymer becomes too soft, so that the sticky feeling on the skin is too large, and the pressure-sensitive adhesive provided on the support has a cold flow. This is because there is a danger that the soft tackifier will flow out or that too much of the soft tackifier will migrate to the surface of the pressure-sensitive adhesive and cause bleeding.

The cross-linking agent is an essential component of the soft viscous pressure-sensitive adhesive, and the polymer softened by the soft viscous agent is solidified by cross-linking to give a certain cohesive force. It works as an adhesive with power. The amount of the crosslinking agent to be used is suitably in the range of 0.25 to 10.0% by weight of the active ingredient. That is,
When the amount is less than 0.25% by weight, it is difficult to sufficiently cross-link the polymer, especially when a large amount of a softening agent is contained.
Because it is not possible to increase the cohesion of the polymer,
If the amount exceeds 10.0% by weight, the adhesive strength and the cohesive strength are excessively reduced due to the relationship with the crosslinking density, and the physical properties change with time is unfavorably large.

On the other hand, when a hydrophilic high molecular substance is added to the above-mentioned soft viscous adhesive for the purpose of absorbing water such as body fluid, the ratio of the alkyl acrylate copolymer to the hydrophilic high molecular substance becomes solid. The range of 99/1 to 70/30 is appropriate in a division ratio. The reason is that when the ratio of the hydrophilic polymer substance exceeds 30%, the water absorption of the polymer increases,
This is because the tackiness of the pressure-sensitive adhesive becomes too large, which is not preferable. If it is less than 1%, the effect of the addition of a hydrophilic polymer substance having a function of preventing soft viscous bleeding in the pressure-sensitive adhesive and absorbing body fluid at the time of application is provided. Is not substantially recognized and is not preferred.

Needless to say, the amounts of the components used are expressed in terms of the solid content in terms of the base polymer and in terms of the active ingredients in terms of the polymer softener and the crosslinking agent. In many cases, it is diluted with a solvent such as toluene, ethyl acetate, MEK, alcohol, acetone, hexane and water in an amount suitable for Because it is not appropriate.

Next, in the present invention, the soft viscous pressure-sensitive adhesive obtained as described above is used for polyethylene, polypropylene, polyethylene terephthalate, ethylene-methyl methacrylate, soft polyvinyl chloride, nylon, polyurethane,
Ethylene-vinyl acetate copolymers, polyether polyamide block copolymers, styrene-butadiene-styrene block copolymers, styrene-isoprene-styrene block copolymers, and films including foam films made from hydrogenated products thereof, and cotton-synthesis Woven fabric, knitted fabric, nonwoven fabric made of fibers such as fiber, such as polypropylene, polyethylene, polyester, nylon, and natural cellulose, or paper monolayer or laminate made of natural paper, synthetic paper, etc. By directly applying or laminating on one or both surfaces of a support made of a laminate obtained by combining two or more of these, for example, a roll-shaped patch 1 shown in FIG. 1 or FIGS. A patch (sheet) 1 shown in FIG. Note that the shape of the patch need not be limited to the shape shown in these drawings, but may be any shape within a range in which the dosage form can be processed.

The thickness of the soft viscous pressure-sensitive adhesive provided in the patch of the present invention is preferably 20 μm to 50 μm, but is not particularly limited to this range. You can choose.

The patch of the present invention thus obtained is
It has low irritation performance that does not hurt the stratum corneum on the skin surface during peeling after application. This is because, in part, by adding a polymer softener, it was possible to obtain low tackiness and high tack performance, and by adding a selected crosslinking agent, the soft viscosity was maintained. This was because the cohesive force of the pressure-sensitive adhesive could be ensured, and a patch with extremely low peel resistance at the time of peeling could be obtained.

Furthermore, the patch of the present invention has a repetitive sticking performance that allows double sticking. This is because the adhesive layer of this patch is soft and has a large adhesive area when applied to the skin, etc., has high wettability to the skin, has good followability to the skin, etc., and has the adhesive as described above. Because the layer is composed of a low viscosity and a soft viscous adhesive with a certain cohesive force, there is almost no peeling of the stratum corneum and no adhesive residue due to peeling. Repeated attachment is possible.

Furthermore, the patch of the present invention has an anti-fogging property which is resistant to fogging even when applied for a long time. Fogges can be broadly classified into those caused by chemical stimulation of the adhesive and those caused by physical stimulation, but the patch of the present invention comprises a pressure-sensitive adhesive layer composed of a soft viscous adhesive,
It has the property that it has high followability to the skin and hardly causes physical skin irritation. In addition, since a low-stimulant alkyl acrylate copolymer or a blend of the alkyl acrylate copolymer and a hydrophilic polymer is used as the base polymer of the pressure-sensitive adhesive, there is little blurring due to chemical irritation. For this reason, the patch of the present invention has an anti-fogging property which is resistant to fogging even when applied for a long time. More specifically, a patch composed of a soft viscous adhesive in which a hydrophilic polymer substance is mixed into a pressure-sensitive adhesive component, or a patch composed of a hydrophilic polymer substance in a pad as described later, is formed of such a hydrophilic polymer. Since the substance is particularly excellent in water absorbency, it can absorb body fluid exuding from the diseased part or the like to be worn without exposing it, keep the area around the diseased part clean, and protect the diseased part and the part around the diseased part from propagation of various bacteria and contamination thereof. In addition, in the case of a soft viscous adhesive in which a hydrophilic polymer substance is mixed into an adhesive component and deliquescent is observed, an alkyl acrylate copolymer and a hydrophilic polymer substance may be used respectively. Simultaneous crosslinking can be prevented, but in this case, a hydrophilic polymer substance having a functional group such as a carboxyl group, an amino group, an amide group, or a hydroxyl group as a crosslinking point is selected.

In the patch of the present invention, for example, as shown in FIG. 3, a pad 6 can be attached to the surface on which the soft viscous adhesive layer 3 is provided. In this case, the soft viscous adhesive layer 3 It is preferable that the sheet is pasted so as to protrude at least 5 mm outside. This is, for example, after the support and the pressure-sensitive adhesive layer are punched into a desired shape and size, or at the same time as the punching process, at a desired position of the soft viscous pressure-sensitive adhesive layer 3, the pressure-sensitive adhesive layer 3 is moved from the outer edge 6 a of the pad 6. This is achieved by applying the pad 6 so as to protrude at least 5 mm outside. In this case, the pressure-sensitive adhesive layer 3 may be adhered such that the entire back surface of the pad 6 is placed on the pressure-sensitive adhesive layer 3, or the support and the pressure-sensitive adhesive layer previously punched into a frame having a desired width may be bonded to the pad 6. May be adhered to the back surface of the pad so that the adhesive layer 3 protrudes from the outer edge 6a of the pad 6 along the outer periphery of the pad.

The pad used in the patch of the present invention can be coated, kneaded, impregnated or bonded with a pharmaceutically active ingredient such as a drug which can permeate through a biological membrane or a biologically active substance which stimulates a living body over time. The pharmaceutically active ingredients include anti-inflammatory analgesics, anti-inflammatory agents, analgesics, antihistamines, anti-allergic agents, local anesthetics, antibacterial agents (antibacterial agents, antifungal agents, antiviral agents, etc.), antihypertensive agents, antihypertensive agents Diuretics, cardiotonic agents, vasodilators, vasoconstrictors, antiarrhythmic agents, cardiovascular agents,
Antiepileptic, antivertigo, tranquilizer, sleeping pill, autonomic nervous, hormonal, antihormonal, respiratory,
Keratin softener, anticoagulant, antibiotic, antitumor agent, herbal medicine,
Vitamins, blood circulation promoters and the like can be mentioned, and these can be used alone or in combination of two or more.

The pad used in the patch of the present invention may contain one or more hydrophilic polymer substances such as carboxyvinyl polymer, polysaccharide, cellulose, and polyvinyl alcohol. As the carboxyvinyl polymer, polyacrylic acid, polymethacrylic acid and alkali metal salts thereof, and the like. Further, as the polysaccharides, starch, starch derivatives, dextrin, dextran, chitin, alginic acid, alginic acid sodium salt, glycogen, carrageenan and other single polysaccharides,
Complex polysaccharides such as mannan, pectin, gum arabic, gum karaya, and xanthan gum are exemplified. Further, examples of the celluloses include methylcellulose, ethylcellulose, propylcellulose, methylpropylcellulose, hydroxymethylcellulose, and alkali metal salts of hydroxyethylcellulose.

Further, as shown in FIG. 4, for example, the patch of the present invention is a support 2 having a two-layer structure in which a woven or knitted fabric 2b is thermocompression-bonded to one surface of a film 2a. The adhesive 1 having the soft viscous pressure-sensitive adhesive layer 3 provided on the surface of the woven or knitted fabric 2b to such a thickness that the compressed woven or knitted fabric 2b is not exposed to the surface layer can be used.

By adopting such a structure, the patch of the present invention can provide a waterproof property capable of preventing water from entering from the interface of application to the skin, and particularly, a woven or knitted fabric provided on one side of the film. A relatively thin film can be provided with a so-called "strain" (toughness) by a cloth, and the amount of a pressure-sensitive adhesive which needs to be thick enough to fill a skin groove due to the presence of a woven or knitted fabric can be reduced. be able to.

The woven or knitted fabric to be used is not particularly limited, but preferably has a fiber thickness of 20 to 50 denier and a porosity of 60 to 85%. . The reason is that a fiber having a fiber thickness of less than 20 denier is too thin, and there is a problem that a large amount of adhesive is required to cover the fiber. 6 more
This is because those having a porosity of less than 0% are too coarse for the purpose of the present application to give "strain" to the support, and the effect of reducing the amount of the pressure-sensitive adhesive cannot be expected so much.

On the other hand, the soft viscous pressure-sensitive adhesive used in the patch of the present invention has a particularly important function in preventing water from entering the skin patch interface. That is, a conventional patch used for such waterproofing uses a support having a thickness of about 30 μm and a pressure-sensitive adhesive layer having a slightly thicker thickness of about 60 μm.

However, such a conventional pressure-sensitive adhesive has a large cohesive force and is hard to flow (that is, “hard”), so that it is difficult for the pressure-sensitive adhesive to penetrate into the skin groove even when wound strongly. As a result, it is often the case that water infiltrates from the application interface to the skin. In order to prevent water from entering, the thickness of the pressure-sensitive adhesive layer is coated to a thickness of 80 to 90 μm to compensate for the defect of the hardness of the pressure-sensitive adhesive. In the case of having a pressure-sensitive adhesive, the pressure-sensitive adhesive layer is too heavy compared to the rigidity of the support, so that not only is it difficult to maintain the shape as a patch, but also the pressure-sensitive adhesive tends to protrude (cold flow) during storage.

On the other hand, since the soft viscous pressure-sensitive adhesive of the present invention has a soft viscosity, the pressure-sensitive adhesive penetrates deep into the skin groove at the time of application, so that water does not penetrate from the interface of application to the skin at all. Absent.

Even when the thickness of the pressure-sensitive adhesive layer is about 20 to 50 μm, a sufficient waterproof effect is exhibited, so that there is no need to provide an extra amount of pressure-sensitive adhesive. Further, the soft viscous pressure-sensitive adhesive of the present invention has been subjected to a cross-linking treatment with a cross-linking agent, so that there is no possibility of adhesive residue when peeled off.

Furthermore, the patch of the present invention can have a substantially non-adhesive portion of a desired shape in a desired portion in a soft viscous pressure-sensitive adhesive layer provided on one side or both sides of a support. For example, as shown in FIG. 5, a patch 1 having a substantially non-adhesive portion composed of a pattern 7 in the soft viscous adhesive layer 3 can be obtained.

In general, when a patch requires high air permeability such as a case of sticking without replacement for a long period of time, it is not sufficient to provide the support with air permeability. It is necessary to have sex. In such a case, it is possible to impart air permeability to the pressure-sensitive adhesive layer by a method of forming a gap between the pressure-sensitive adhesive layers such as spot coating or partial coating of the pressure-sensitive adhesive. When used, the pressure-sensitive adhesive generally used has a reduced adhesive area, resulting in too low an adhesive force (adhesive holding force) to an adherend, which cannot easily follow the movement of the adherend, and immediately peels off. Disadvantages occur.

On the other hand, the soft viscous pressure-sensitive adhesive of the present invention has a high adhesiveness to the skin because the pressure-sensitive adhesive is soft, and sufficiently adheres to an adherend (skin or the like) even with a small adhesive area, so that the adhesive may Can flexibly follow, and even if a non-adhesive portion having a desired shape is provided in the adhesive layer, no phenomenon such as spontaneous peeling occurs.

The shape of the substantially non-adhesive portion provided in the soft viscous pressure-sensitive adhesive layer of the present invention may be a combination of straight lines, a combination of curves, a combination of dotted lines or dots in gravure coating or drawing coating. Can be configured in a shape, or a combination of any two or more of these, but the coating method is not particularly limited, and in fact, the substantially non-adhesive portion has a desired shape in the pressure-sensitive adhesive layer. Any method may be used as long as it can be obtained.

Further, the reason why the substantially non-adhesive portion of the pressure-sensitive adhesive layer is formed as a pattern is, in part, to give a visual aesthetic to a user. This is to further increase the air permeability of the pressure-sensitive adhesive layer.

[0054]

EXAMPLES The excellent performance of the patch of the present invention is shown below. Example 1 45 g of 2-ethylhexyl acrylate, 50 g of butyl acrylate, 5 g of acrylic acid and 45 g of ethyl acetate were placed in a reactor equipped with a thermometer, a stirrer, a reflux condenser, a nitrogen inlet tube and the like.
g. The mixture was heated to 80 ° C. while stirring under a nitrogen stream, and when the reaction system reached 70 ° C., a polymerization initiator solution (0.2% lauroyl peroxide solution) was added over 5 hours. The polymerization reaction was carried out by dropping, and the solid content was 6
A 0% acrylic pressure-sensitive adhesive solution was obtained. Further, this pressure-sensitive adhesive solution was dried to obtain a non-solvent acrylic pressure-sensitive adhesive having a solid content of 100%. Next, this non-solvent acrylic pressure-sensitive adhesive was dissolved in toluene to obtain a pressure-sensitive adhesive (A0) having a solid content of 40%, and isopropyl myristate and a cross-linking agent were added to the pressure-sensitive adhesive. Agents A1, A2, A3 and A4 were obtained. Each of the obtained soft viscous pressure-sensitive adhesives was coated on one side of a PET # 25 film with a paste thickness of 30 μm, dried by heating, cut, and cut into a patch. 1,2,3,4 were obtained. The adhesive performance, repeated application performance, and peeling stimulus performance of these patches were measured, and the results in Table 2 were obtained.

[0055]

[Table 1]

[0056]

[Table 2]

Example 2 The soft viscous adhesive obtained in Example 1 (A1, A2, A3,
A4) is coated (paste thickness 40 μm) on the release surface of the process paper that has been subjected to release processing, heated and dried, and then bonded and transferred to a nonwoven fabric (Sontara # 8010 (manufactured by DuPont)). No. 5, 6, 7, 8 were obtained. When the antifogging performance of these patches after long-term application was examined, the results shown in Table 3 were obtained.

[0058]

[Table 3]

Example 3 The soft viscous adhesive obtained in Example 1 (A1, A2, A3,
A4) was coated on a 30 μm-thick urethane film having a fiber thickness of 35 denier (porosity 70%) thermocompression-bonded to one side of a 30 μm-thick urethane film at a paste thickness of 40 μm, and dried by heating. after, pasting and cut agent No. 9, 10, 11,
12 was obtained. When the waterproof performance of these patches was examined, the results shown in Table 4 were obtained.

[0060]

[Table 4]

Example 4 The non-solvent acrylic pressure-sensitive adhesive obtained in Example 1 was dissolved in toluene to form a pressure-sensitive adhesive having a solid content of 40%, and the hydrophilicity of the acrylic polymer dispersed in methyl alcohol in this pressure-sensitive adhesive was measured. The water-soluble polymer substances were uniformly stirred and mixed, and then isopropyl myristate and a crosslinking agent were added to obtain soft viscous adhesives B1 and B2 having the composition shown in Table 5. Next, these soft viscous adhesives are applied (paste thickness 30 μm) to the release surface of a process paper subjected to release treatment using a gravure roll engraved with a pattern shown in FIG. After doing
Adhesive No. No. was attached and transferred to a 30 μm-thick urethane film. 13 and 14 was obtained. When the ventilation performance (moisture permeability) of these patches was examined, the results shown in Table 6 were obtained.

[0062]

[Table 5]

[0063]

[Table 6]

Example 5 Patch No. 5 obtained in Example 4 13, 14 with length 10
cm, a width of 8 cm, and a compound containing a hydrophilic polymer having a length of 6 cm, a width of 4 cm, and a thickness of 0.1 cm (50 parts of karaya rubber, CMC-Na
50 parts, pectin 100 parts, gelatin 130 parts, EVA
15 parts, white carbon 20 parts, polyisobutylene 2
50 parts), and the patch No. 15,
16 was obtained. When the water leakage resistance and the water absorption performance of these patches were examined, the results shown in Table 7 were obtained.

[0065]

[Table 7]

As can be seen from the results in each of the tables, the patch of the present invention has low irritation performance, repetitive lamination performance capable of being applied twice, and anti-fogging performance over a long period of application, and also has water infiltration from the application interface. It was an excellent patch that could impart waterproofing properties, high air permeability, and water absorption that could quickly absorb body fluids and the like.

[0067]

The patch of the present invention has the following properties because it is constituted as described above. Excellent hypoallergenic performance that does not hurt the stratum corneum on the skin surface during peeling after application. Twice stuck stuck capable of excellent repeated sticking performance. Excellent anti-fogging performance that resists fogging during long-term application. Excellent waterproof performance that can prevent water from entering the bonding interface. Excellent ventilation performance to prevent stuffiness and dripping of the affected area. Excellent high water absorption performance to absorb body fluids quickly.

[Brief description of the drawings]

FIG. 1 is a perspective view of a patch of the present invention in the form of a roll.

FIG. 2 is a partially broken perspective view of the patch of the present invention in a strip shape.

FIG. 3 is a perspective view of the patch of the present invention having a shape in which a pad is provided on a soft viscous pressure-sensitive adhesive layer.

FIG. 4 is a partially broken perspective view of the patch of the present invention comprising a support having a two-layer structure of a film and a knitted fabric and a soft viscous adhesive.

FIG. 5 is a partially cutaway perspective view of the patch of the present invention having a substantially non-adhesive pattern in a soft viscous pressure-sensitive adhesive layer.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Adhesive 2 Support 2a film 2b knitted fabric 3 Soft viscous adhesive (layer) 4 Core tube 5 Release paper 6 Pad 6a Pad outer edge 7 Pattern

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61L 15/58 A61L 15/06 (72) Inventor Yoneo Hirakawa 3-20 Tachibana, Nishinari-ku, Osaka-shi, Osaka No. 28 F-term in Kyowa Co., Ltd. (reference) 4C081 AA03 BB04 BB06 CA052 CA081 CD012 CD022 CE01 CE02 CE11 DA02 DA05 DC03

Claims (8)

[Claims] 1. An alkyl acrylate copolymer having a functional group, a fatty acid alkyl ester or a polymer softener selected from oils containing a fatty acid alkyl ester, and an epoxy, a metal chelate, an isocyanate, a melamine, and an ethyleneimine. Or a low-irritation performance that does not hurt the stratum corneum of the skin surface upon peeling after application, characterized in that a soft viscous adhesive layer containing a crosslinking agent selected from ethylenethiourea is provided on one or both sides of the support,
A patch that has repetitive sticking performance that can be stuck twice, and has anti-fogging performance that is resistant to fogging even when sticking for a long time. 2. The soft viscous adhesive contains 85 to 50% by weight of the acrylic acid alkyl ester-based copolymer in solid content,
The patch according to claim 1, wherein the adhesive contains 15 to 30% by weight of the polymer softener as an active ingredient and 0.25 to 10.0% by weight of the crosslinker as an active ingredient. 3. The soft viscous adhesive is an acrylic polymer,
At least one hydrophilic polymer selected from a graft starch-based polymer and a cellulose-based polymer is used in a solid content ratio of 99/1 to 70/30 (alkyl acrylate) with respect to the alkyl acrylate copolymer. The patch according to claim 1 or 2, further comprising a ratio of (system copolymer / hydrophilic polymer substance). 4. A patch in which a pad is stuck to the soft viscous pressure-sensitive adhesive layer, wherein the soft viscous pressure-sensitive adhesive layer protrudes at least 5 mm outside an outer edge portion of the pad. The patch according to any one of claims 1 to 3. 5. The patch according to claim 4, wherein the pad contains at least one substance selected from carboxyvinyl polymers, polysaccharides, celluloses, and polyvinyl alcohol. 6. The support according to claim 1, wherein the support comprises a single layer or a laminate of a film, a woven fabric, a knitted fabric, a nonwoven fabric, a paper, or a laminate of a combination of two or more thereof.
The patch according to any one of claims 1 to 5, wherein 7. The woven or knitted fabric on one surface of said support film becomes to allowed thermocompression bonding, the woven fabric thickness which 軟粘 adhesive is the woven or knitted fabric is not exposed to the surface or The patch according to claim 6, which is provided on a knitted fabric surface. 8. The method according to claim 1, wherein the soft viscous pressure-sensitive adhesive layer provided on one surface or both surfaces of the support has a substantially non-adhesive portion having a desired shape at a desired position. The patch according to any one of the above.