JP2002193216A - Press-through pack packaging apparatus and press- through pack package - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a PTP package which has excellent formability and curling property. SOLUTION: PTP packaging apparatus has heat reserving effect on a heating part by covering a periphery of the heating part in a heating plate by a partial heating method, with an insulating material.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a stamping press generally used for packaging solid preparations in the field of pharmaceutical packaging.
Through-pack (hereinafter abbreviated as PTP) packaging device and P
It relates to a TP package.

[0002]

2. Description of the Related Art In the field of pharmaceutical packaging, PTP packaging, which is generally used for packaging solid tablets such as tablets and capsules, is mainly made of rigid polyvinyl chloride in terms of transparency, moldability, rigidity, and cost. Is used as a bottom material, the bottom material is formed into a pocket shape, and a solid agent (tablet,
Capsules) and sealed with a lid made of aluminum foil, which was put into practical use and widespread in the early 1960s.

[0003] Most of the contents of tablets, capsules and the like are deteriorated or deformed by absorbing moisture.
This has been dealt with by providing secondary packaging such as pillow packaging with a composite film containing aluminum foil, or by using a sheet in which a rigid polyvinyl chloride sheet is composited with a coating of polyvinylidene chloride resin with excellent moisture resistance. These are expensive and have a problem in cost. In addition, the tendency of polyvinyl chloride resin to be avoided due to the problem of disposal is increasing. Therefore, recently, sheets made of polypropylene resin, which is an olefin-based resin, have been attracting attention for their moisture-proof properties, low cost properties, and easy processability.
It has been used as a TP packaging sheet.

However, polypropylene as a sheet for PTP has a problem that the molding condition range is narrower than that of polyvinyl chloride, and the product is curled and trouble occurs in appearance or in an automatic packaging line accumulation and pillow packaging, and the machine stops. There were problems such as doing. These problems are due to the fact that polypropylene is a crystalline resin, and attempts have been made to increase the crystallinity of polypropylene in order to improve curl, using a nucleating agent or slow cooling during sheeting. In addition, methods such as annealing the sheet were performed, but the moldability was conversely deteriorated, and was not suitable for actual use. In order to improve moldability, a method of suppressing crystallinity by adding a petroleum resin to a homopolymer of polypropylene has been adopted, but this method has a disadvantage that impact resistance is significantly impaired. . In order to improve the impact resistance, a method of adding a thermoplastic elastomer (TPE) has been adopted, but the impact resistance is improved with an increase in the amount of TPE added, but at the same time, the rigidity and the moisture resistance are reduced. was there. Attempts have also been made to reduce the crystallinity by quenching at the time of sheeting in order to improve the formability. However, in this method, the stiffness of the sheet becomes extremely weak, and the sheet cannot be used for practical use.
In addition, a method of laminating an amorphous polyolefin with excellent mechanical strength, moldability, transparency, dimensional stability and moisture resistance and a crystalline polyolefin to supplement the impact resistance to form a composite sheet has been attempted. Although good results are obtained in both curl and moldability, the cost of amorphous polyolefins is problematic as a substitute for polyvinyl chloride due to the high price. As described above, at present, it is difficult to bring out excellent mechanical properties and properties equivalent to polyvinyl chloride only in terms of the material of the PTP package.

[0005] In view of the PTP packaging apparatus, the following improvements have been made with an emphasis on curling of the above-mentioned problems. As the conventional heating plate, a heating plate that heats the entire surface of the sheet or most of the sheet has been used. Although this form has no problem in moldability, when a crystalline resin such as PP is used for the bottom sheet in curl properties, the curl becomes large and causes trouble in the transport section and the pillow packaging section in the PTP packaging line. Therefore, as measures to improve this, a method using a pin point heating method in which only the heating portion of the heating plate is formed, a method of cooling with an air blow or the like after sealing with aluminum which is a lid material of a PTP packaging. And how to do it. Of these methods, the method of heating at a pinpoint is particularly effective, and is not only good in curl properties immediately after molding but also good with time. However, the pinpoint heating method has a problem in formability because the heating area is small and the number of times of heating is smaller than in the past. For this reason, measures such as suppressing the line speed are taken, but as a result, productivity is reduced.

[0006]

DISCLOSURE OF THE INVENTION The present invention is intended to solve the problems of curl and moldability of a sheet for a bottom material of a PTP packaging at the same time, and to make an examination from the aspect of a PTP packaging apparatus. However, it is an object of the present invention to provide a PTP package excellent in moldability and curl.

[0007]

SUMMARY OF THE INVENTION The present invention relates to a PTP packaging apparatus characterized in that in a heating plate of a partial heating system, the periphery of a heating section is covered with a heat insulating material to thereby have an effect of keeping the heating section warm. Preferably, in this case, the temperature around the heating section (the temperature of the heat insulating material) is lower than the recrystallization temperature of the PTP bottom material used. More preferably, the temperature around the heating section (the temperature of the heat insulating material) is normal temperature.

[0008]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention covers a heating portion of a partial heating plate with a heat insulating material to prevent heat radiation of the heating portion, thereby giving a sufficient amount of heat for forming while suppressing residual stress and crystallization of the sheet. A PTP packaging apparatus characterized by having a mechanism capable of performing the PTP packaging.

Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 shows a bottom view of an example of a heating plate covered with a heat insulating material according to the present invention. FIG. 2 is a sectional view taken along the line AA ′ in FIG. The sheet for the bottom material of the PTP package used in the PTP package of the present invention may have any composition as long as it does not impair the basic characteristics of the PTP application, and the thickness is not particularly limited. Preferably, the following may be used as constituents of the PTP packaging bottom sheet. Base resins include polyvinyl chloride, polyvinylidene chloride, polypropylene, polyethylene, polystyrene, polymethyl methacrylate,
Polycarbonate, polyester, polyvinyl alcohol, polyvinyl acetate, thermoplastic elastomer, cyclic polyolefin, ethylene-methacrylate copolymer, ethylene-vinyl acetate copolymer, ethylene-acrylic acid copolymer, ethylene-vinyl acetate-methyl methacrylate copolymer Copolymers of an organic carboxylic acid derivative having an ethylenically unsaturated bond such as a coalescence with ethylene and the like can be mentioned.
Examples of the additives include a crystal nucleating agent, an antistatic agent, an ultraviolet absorber, a lubricant, an antioxidant, a light stabilizer, an antiblocking agent, a surfactant, a dye, a pigment, a flame retardant, and a plasticizer.

[0010] PTP used in the PTP package of the present invention
The method for producing the packaging bottom material sheet is not particularly limited, but is a co-extrusion method in which the resin is melt-extruded with several extruders and guided to a multilayer die or a feed block to form a sheet, or each layer is formed. Examples include a dry lamination method in which a single-layer sheet or film is bonded using an appropriate adhesive, an extrusion lamination method, a combination of these methods, and a calendar method. The thickness of the sheet is usually in the range of 0.15 to 0.6 mm, preferably in the range of 0.20 to 0.35 mm.

The heat insulating material of the present invention is characterized in that it keeps the heating portion of the heating plate warm, does not impair the heat retention effect of the heating portion by being deformed by heating (has a low coefficient of thermal expansion), and has a temperature of the heating plate. Not to be softened (the softening temperature or melting point of the heat insulating material is higher than the heating temperature of the heating plate), and the toxic components are not discharged. There is no particular limitation as long as it has no adverse effect. Preferably, the material of the heat insulating material is an organic polymer material or a ceramic material. For example, organic polymers include thermosetting resins such as epoxy resin, melamine resin, phenolic resin, polyurethane, Teflon, polycarbonate, polyethersulfone, and polyetheretherketone, and engineering plastics. Fiber, rock wool, vermiculite, cordierite, calcium silicate, perlite, and the like.In addition to the above, asbestos,
Glass fiber reinforced polyester and the like.

[0012]

EXAMPLES The present invention will be described in more detail with reference to the following examples, which are merely illustrative and the present invention is not limited to these examples. (Example 1) A polypropylene (PP) -based single-layer PTP sheet NS-3450 (manufactured by Sumitomo Bakelite Co., Ltd.) was used as a bottom material sheet of a PTP package, and a PTP molding machine (C.
In FBP-M2 manufactured by KD Co., Ltd., using a tablet type (diameter 10 mmφ, depth 5 mm), a heating plate (heating part diameter: 12 mmφ) in a mode of partially heating is a heat insulating material around the entire heating part. , Plug temperature 130 ° C, air blow pressure 0.50MPa, line speed 3.7m / m
The molding was performed in, and the molding temperature range was determined by comprehensive evaluation of the mold followability to the molding die, the unevenness of the appearance of the pocket top, and the thickness of the top. The mold followability and the uneven appearance of the top were visually evaluated, and the thickness of the top was obtained by measurement with a dial gauge. The uniformity of the thickness distribution of the molding pocket was divided into two parts by a cutter blade and judged by a cross-sectional photograph. As a result, the molding temperature range was 136 to 142 ° C.

Next, a lid obtained by coating a molded product obtained at a molding temperature of 138 ° C. with a sealing temperature of 200 ° C. and a sealing pressure of 0.50 MPa at a sealing temperature of 0.50 MPa with a hard aluminum foil of 20 μm coated with 5 μm of maleated polypropylene. Sealed with aluminum foil as material. After putting a slitter into the obtained PTP package at 130 ° C., place the PTP package punched into a width of 37 mm, a length of 94 mm and a corner of 5 mm on a flat surface, and measure the curl height of the molded product immediately after the punching. did. The curl height was determined as the curl height by measuring a total of four points of each molding pocket angle for ten molded articles and calculating an average value. Table 1 summarizes the evaluation results. Furthermore, this PT
The curl height after the P package was left at room temperature for 48 hours was similarly measured.

(Comparative Example 1) In place of the heating plate used in Example 1 in which the entire area around the heating section is covered with a heat insulating material and which is partially heated, upper and lower heating plates in which the entire sheet is heated are used. Except for this, a polypropylene (PP) -based single-layer PTP sheet NS-3450 (manufactured by Sumitomo Bakelite Co., Ltd.) was molded in the same manner as in Example 1, and the molding temperature range was determined. The molding temperature range in this case was 134 ° C to 142 ° C. Next, a PTP package sealed with aluminum foil was prepared in the same manner as in Example 1 without filling the molded product obtained at a molding temperature of 138 ° C. with the contents, and the curl height immediately after punching and after standing for 48 hours was measured. Was evaluated. Table 1 summarizes the evaluation results.

(Comparative Example 2) In place of the heating plate used in Example 1 in which the entire periphery of the heating section is partially covered with a heat insulating material and the sheet is partially heated only in the forming area, A polypropylene (PP) -based single-layer PTP sheet NS-3450 (manufactured by Sumitomo Bakelite Co., Ltd.) is formed and molded in the same manner as in Example 1 except that an upper and lower heating plate (diameter of a heating portion: 12 mmφ) is used. The temperature range was determined.
The molding temperature range in this case was 136 ° C to 138 ° C. Next, a PTP package sealed with an aluminum foil was produced in the same manner as in Example 1 without filling the molded product obtained at a molding temperature of 138 ° C. with the contents. The time required for sealing the aluminum foil was 1.43 times that of Example 1, and the production capacity was 70% of that of Example 1. The curl height of the obtained PTP package immediately after punching and after standing for 48 hours was evaluated. Table 1 summarizes the evaluation results.

[0016]

[Table 1]

[0017]

According to the present invention, a PTP package having good moldability and small curl can be obtained without impairing the basic characteristics for PTP use.

[Brief description of the drawings]

FIG. 1 shows a bottom view of an example of a heating plate covered with a heat insulating material according to the present invention.

FIG. 2 is a cross-sectional view taken along the line A-A 'of FIG.

[Explanation of symbols]

 1 Heating part 2 Insulation material

Claims (2)

[Claims] 1. A press-through-pack packaging apparatus characterized in that a heating plate of a partial heating system has a heat retaining effect by covering the periphery of a heating unit with a heat insulating material. 2. A press-through pack package packaged by the press-through pack packaging device according to claim 1.