JP2002191303A - Propolis processed food - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an easily ingestible propolis essence processed food. SOLUTION: This propolis processed food is characterized by being obtained by filling propolis essence powder containing propolis essence and a vehicle in hard capsules or by filling propolis essence powder and 0.01 pt.wt. to 15 pts.wt. of cellulose and/or starch per the propolis essence powder in hard capsules.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a processed propolis food in which a hard capsule is filled with a propolis extract powder.

[0002]

2. Description of the Related Art Propolis is a substance that a worker bee collects sap such as young shoots of a plant and mixes it with its own saliva to produce a resin component, aromatic oil, beeswax, volatile oil, pollen,
It is a resinous substance containing minerals and the like. This propolis has a function as a defense fence that prevents invasion of foreign enemies into the beehive, as well as a reinforcing agent when closing a crack in the nest, and also covers corpses such as small animals and insects and prevents corruption. It is also known to be used for this purpose (JP-A-9-149765).

As described above, propolis having various functions has been recognized to have a wide range of physiological activities such as anti-inflammatory action, anti-ulcer action, antibacterial action, and antioxidant action even in humans. Ulcer, treatment and prevention of diseases such as arteriosclerosis, it is thought to be useful for beauty, etc., the active ingredient of propolis, lipophilic components such as flavonoids, hydrophilic components such as organic acids, intermediate components thereof, Furthermore, since it is a vitamin and a mineral, a water-containing ethanol solution of a propolis extract extracted with water-containing ethanol is widely used as a raw material for health foods, cosmetics, and the like.

On the other hand, currently available processed propolis foods are sold in various forms, such as tinctures, tablets, soft capsules, and powders. Is currently not sold at all. Therefore, usually, a vegetable oil such as wheat germ oil, an emulsifier such as lecithin, or a dispersion stabilizer such as pectin or beeswax is added to a water-containing ethanol solution of the propolis extract to reduce the viscosity, and then the propolis is removed by removing ethanol. Propolis processed foods in which a composition is manufactured and filled in a soft capsule such as an oval type or a tear type are generally sold.

[0005] As described above, propolis is widely used as a health food having excellent functions. However, since the above-mentioned aqueous ethanol solution of the propolis extract is liquid, it is inconvenient to handle. , Instruments, skin,
If attached to skin or clothing, cleaning is extremely difficult. Also,
There is a problem that tablets and capsules, which are the main dosage forms of health foods, cannot be manufactured as they are.

[0006] The above-mentioned propolis composition used for soft capsules contains ethanol at a high concentration of 1% or more, and is not always satisfactory as a processed food for propolis, because the ethanol odor remains. Not something you can do. For example, ethanol is evaporated by adding 15 to 30% by weight of wheat germ oil to an ethanol solution of a propolis extract obtained by extracting an active ingredient from raw propolis with ethanol, and performing ethanol concentration under reduced pressure to evaporate ethanol. A technique for lowering the ethanol content has been reported (Japanese Patent Application Laid-Open No. 9-206002), but in this case, if ethanol is forcibly evaporated, the fluidity deteriorates, and the ethanol does not mix with other added components, thereby forming an insoluble matter. However, there is a problem that the suitability as a food material is deteriorated.

[0007] In addition, since the soft capsule filled with the above-mentioned propolis composition is in a modified dosage form such as an oval type or a tear type, it is very difficult to swallow, such as being stuck in the throat, when taken orally. There is also a problem that the disintegration time after oral ingestion is 15 to 20 minutes, which is not excellent in disintegration, and is not excellent in dispersibility.

[0008] Propolis-processed foods are also produced by powdering a water-containing ethanol solution of a propolis extract together with excipients such as starch, etc., and producing a tableted propolis processed food. Due to the characteristics of the powder, the fluidity is low, and tableting troubles such as sticking are likely to occur. In addition, in the case of tableting, there is a problem that the amount of propolis extract per grain is reduced due to an increase in the number of excipients, so that the number of grains to be taken at one time is also increased.

[0009] Further, a powder obtained by granulating a water-containing ethanol solution of a propolis extract is also manufactured and sold. However, when taken orally, the powder has a provocative taste unique to propolis and is extremely difficult to drink. There is. In addition, in the case of granulation, there is a problem that the amount of propolis extract per serving is reduced due to an increase in the amount of excipients, so that the amount to be taken at one time becomes extremely large.

[0010]

SUMMARY OF THE INVENTION An object of the present invention is to provide a propolis process which is free from the problem of ethanol odor, has a high content of propolis extract per unit dose, and can be easily taken when taken orally. To provide food.

[0011]

Means for Solving the Problems The present inventors filled procapsule extract powder into hard capsules, and had no problem of ethanol odor, a high content of propolis extract per unit dose, and easily when taken orally. They have found that they can be ingested and can provide an excellent processed food for propolis, and have completed the present invention.

That is, the present invention provides: 1. A processed propolis food, characterized in that a propolis extract powder containing a propolis extract and an excipient is filled in a hard capsule. 2. Propolis extract powder and processed propolis food, characterized by filling a hard capsule with 0.01 to 15 parts by weight of cellulose or / and starch based on 1 part by weight of propolis extract powder. The bulk density of cellulose is 0.10 g / cm ³ or more and 0.60 g
^{3. The} processed propolis food according to 2 above, wherein the processed food has a mean particle diameter of 5 μm or more and 100 μm or less; The processed propolis food according to 2 above, wherein the starch has a water content of 2% or more and 20% or less, a viscosity of 2000 cps or more and 5000 cps or less, and an ash content of 5.0% or less.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION Propolis, which is a raw material of a propolis extract used in the present invention, is a resinous black lump collected by bees, and is produced in any locality such as Brazilian propolis, Chinese propolis, and Australian propolis. And it is not particularly limited. Propolis contains lipophilic components, hydrophilic components, components having intermediate properties and other components. Examples of the lipophilic component include flavonoids, and examples of the hydrophilic component include organic acids such as coumaric acid and cinnamic acid. In addition, examples of the component having an intermediate property between hydrophilicity and lipophilicity include esters and the like, and other components include various vitamins and minerals.

[0014] As described above, since propolis contains various kinds of components, it is not possible to efficiently extract an active ingredient with a solvent consisting of ethanol alone or water alone, and various physiological activities are low. Therefore, it is appropriate to extract the active ingredient in the propolis from the raw propolis with an ethanol solution containing water. This aqueous ethanol solution having an ethanol content of about 40 to 80% by weight, preferably about 50 to 75% by weight is optimal for extracting various active ingredients from the raw propolis, but is not particularly limited thereto. Instead, the ratio of ethanol and water may be appropriately increased or decreased.

The concentration of the propolis extract in the aqueous ethanol solution of the extracted propolis extract is not particularly limited, but is preferably 15 to 70% by weight, more preferably about 20 to 60% by weight. If this concentration is 15% by weight or less, it is necessary to evaporate a large amount of ethanol or water during drying,
When the content is 70% by weight or more, the viscosity of the aqueous ethanol solution may be too high, and the residual amount of ethanol may be increased, or processability may be deteriorated.

[0016] The starch used as an excipient for preparing the propolis extract powder is not particularly limited, but may be generally commercially available starch, preferably a trade name of Matsutani Chemical Industry Co., Ltd. Lactway 2 (potato starch; moisture: 15.0 ± 2.0%, viscosity: 30)
± 10 cps, ash content: 1.5% or less).

This starch is produced by a heating and drying method under reduced pressure, and has a much higher bulk density than that obtained by a conventional spray dryer method, that is, 5.0 cm ^3.
/ g or more 10.0 cm ³ / g large specific surface area as referred to below, for example, a 8.5 cm ³ / g, wear that a large amount adsorbed of each component in propolis. In addition, the water content is about 10 to 30%, for example, about 15%, which is superior in moisture absorption stability as compared with that obtained by a conventional spray dryer method, but the starch has a water content of more than 30%. When the water content of the propolis extract is increased, the hygroscopicity of the solution increases to form a syrup when added to a water-containing ethanol solution. If the water content is less than 10%, the bulk specific gravity is low, and a powdery product with good processability cannot be obtained. There is. In addition, since the particle size of starch is, for example, in the range of 20 to 200 mesh, it is excellent in processability for producing a propolis extract powder.

Next, used for filling the hard capsule,
The method for producing the propolis extract powder will be described,
It is not particularly limited to this. First, an aqueous ethanol solution of an excipient such as starch and a propolis extract is stirred by a mixer, and then concentrated under reduced pressure to recover the aqueous ethanol. The stirring speed in this stirring is 100 to 50.
0 rpm, preferably about 150 to 300 rpm. Next, an excipient such as starch is further added to the concentrate, and the mixture is thoroughly mixed using a mixer. The powdery mixture thus produced is dried by heating under reduced pressure, then pulverized,
By sieving, a powder of propolis extract can be produced. More specifically, 0.3 part of starch and 1 part of an aqueous ethanol solution of propolis extract were mixed in a mixer at 300 r.
After stirring at pm for 2 hours, the mixture is concentrated under reduced pressure to recover about 80% of the aqueous ethanol. Next, 0.5 part of starch is further added to this concentrate, and the mixture is thoroughly mixed with a high-speed mixer for about 5 hours. The powdery mixture thus produced is dried by heating under reduced pressure with a shelf dryer, then pulverized with a chopper type pulverizer or the like, and sieved with a shifter, whereby a powder of a propolis extract can be produced.
Note that the particle size of the powder of the propolis extract is suitably about 40 mesh pass.

The concentration of propolis in this powder is not particularly limited, but is 15 to 70% by weight, preferably 2% by weight.
It is about 0 to 60% by weight. If the amount is less than 15% by weight, it is not possible to obtain an appropriate amount of propolis extract in a small product such as a tablet or a capsule,
If the content is more than 10% by weight, the viscosity of the product increases in the production process, making production difficult.
There is a case where a problem such as the above remains.

The propolis extract powder obtained by the above method is then filled into hard capsules. Filling is generally used for hard capsule filling machine,
For example, it can be performed using GKF-400 manufactured by BOSCH. The propolis extract powder can be filled alone. Furthermore, by filling with cellulose or starch at the time of filling, an excellent propolis-containing hard capsule can be produced.

As cellulose, the bulk density is 0.1 g / cm
³ or more and 0.6 g / cm ³ or less, average particle diameter of 5 μm or more and 100
It is preferable to use cellulose having a size of μm or less, for example, crystalline cellulose. A commercially available product can be used. For example, crystalline cellulose manufactured by Asahi Chemical Industry Co., Ltd., trade name Avicel F-20 (bulk density: about 0.3 g / cm ³ , average particle diameter: 10 to 20 μm) is used. be able to.

As starch, the water content is 2% or more and 20% or more.
Below, the viscosity is 2000 cps or more and 5000 cps or less,
In addition, it is preferable to use starch having an ash content of 5.0% or less, for example, corn starch. A commercially available product, for example, corn starch manufactured by Matsutani Chemical Industry Co., Ltd. (water content: 3% or less, viscosity: 3000 to 4000 cp)
s, ash content: 0.2% or less).

The cellulose or starch is preferably used in an amount of 0.01 to 15 parts by weight, based on 1 part of the propolis extract powder, in a weight ratio of each or both. With respect to the propolis extract powder, 0.1-0.3 parts for crystalline cellulose and 0.1 parts for cornstarch.
In the case of using both in a proportion of 02 to 0.1 part, the mixture can be efficiently filled by mixing and filling at a ratio of 2: 1.

Thus, the above-mentioned propolis extract powder filled in a hard capsule has no problems such that the residual amount of ethanol is 1% or less and has an ethanol odor, and the propolis extract per capsule, which is a unit dose, is not used. It is a processed propolis food that has a high content, is easy to drink when taken orally, and has excellent disintegration properties after ingestion.

[0025]

The present invention will be described below in more detail with reference to examples, but it should not be construed that the invention is limited thereto. [Manufacture of hard capsule type propolis processed food] Example 1

A 70% aqueous solution of Brazilian propolis extract in ethanol (solid content: 21.3 v / v%) 100K
g, starch (trade name: Lactway II, manufactured by Matsutani Chemical Industry Co., Ltd.) (potato starch; moisture: 15.0 ±)
(2.0%, viscosity: 30 ± 10 cps, ash content: 1.5% or less), 30 kg, and the mixture is stirred at a stirring speed of 200 rpm. Thereafter, the mixture was concentrated under reduced pressure to obtain 7% of aqueous ethanol.
8% was recovered. Add 50 kg of starch to this concentrate,
The mixture was sufficiently stirred at a stirring speed of 200 rpm for about 5 hours. After the entire mixture became a uniform mixture, the mixture was dried by heating under reduced pressure at 50 ° C. for 48 hours using a shelf-type hot air dryer. After the dried product was cooled, it was pulverized with a chopper type pulverizer (2 mm mesh screen). Next, this was sieved to 40 mesh or less by a shifter. Further, the powder having a mesh size of 40 mesh or more was further pulverized by using a grinder, and the pulverized product obtained by the grinder was sieved with a shifter to 40 mesh or less to obtain 92.4 g of propolis extract powder. .

300 mg of the obtained propolis extract powder
Was filled in No. 2 hard capsule to produce a hard capsule type propolis processed food. Example 2

The same operation as in Example 1 was repeated to obtain 94.6 g of propolis extract powder.

With respect to 250 mg of the obtained propolis extract powder, crystalline cellulose (trade name, manufactured by Asahi Kasei Kogyo Co., Ltd.)
(Avicel F-20) (bulk density: about 0.3 g / cm ³ , average particle diameter: 10 to 20 μm) 50.0 mg was added and mixed, followed by filling in No. 2 hard capsule to produce a hard capsule type propolis processed food. . Example 3

The same operation as in Example 1 was repeated to obtain 94.3 g of propolis extract powder.

To 250 mg of the obtained propolis extract powder, corn starch (Pharmaco) (manufactured by Matsutani Chemical Industry Co., Ltd.)
(Water: 3% or less, viscosity: 3000 to 4000 cps, ash: 0.2% or less) After adding and mixing 50.0 mg,
No. 2 hard capsule was filled to produce a hard capsule type propolis processed food. Example 4

The same operation as in Example 1 was repeated to obtain 93.5 g of propolis extract powder.

With respect to 250 mg of the obtained propolis extract powder, crystalline cellulose (manufactured by Asahi Kasei Corporation, trade name:
Avicel F-20) (bulk density: about 0.3 g / cm ³ , average particle size: 10 to 20 μm) 35.2 mg, pharmacopoeia corn starch (manufactured by Matsutani Chemical Industry Co., Ltd.) (water content: 3% or less, viscosity: 3
000-4000 cps, ash content: 0.2% or less) 14.8m
After adding and mixing g, the mixture was filled into No. 2 hard capsule to produce a hard capsule type propolis processed food. [Results of filling suitability test]

The suitability for filling was evaluated by the following method.

The content of the hard capsule type propolis processed food obtained in Examples 1 to 4 in the No. 2 hard capsule was 300 mg.
Table 1 shows the results of a study on the filling aptitude of the filling (comprehensive evaluation of the fluidity of the powder and the presence or absence of variation in weight).

As can be seen from Table 1, it is understood that the filling is better when the propolis extract powder is mixed with cellulose or corn starch, or both, and filled.

[0037]

[Table 1] Comparative Example 1 [Production of soft capsule type propolis processed food]

Propolis extract (solid content: 20.8 v
About 80% of ethanol was distilled off from 100 kg using a rotary evaporator, and 100 kg of propolis extract was concentrated under pressure, and this was repeated four times, whereby 21.3 kg of propolis conc extract 4 times concentrated.
I got In addition, 30 parts of wheat germ oil (manufactured by Nisshin Essential Oil Co., Ltd.)
Kg and 5 Kg of beeswax (manufactured by Summit Essential Oil Co., Ltd.) are added and stirred to obtain a propolis extract composition 5
0.23 kg was obtained. By filling 250 mg of this composition into an oval type soft capsule, a soft capsule type propolis processed food was obtained. Comparative Example 2 [Production of tablet-type propolis processed food]

A 70% aqueous solution of Brazilian propolis extract in ethanol (solid content: 21.6 v / v%) 100K
Then, 30 kg of starch (trade name: Lactway II, manufactured by Matsutani Chemical Industry Co., Ltd.) is added to the resulting mixture, and the mixture is stirred at a stirring speed of 200 rpm. Thereafter, the mixture was concentrated under reduced pressure to recover 81% of the aqueous ethanol. To this concentrate was added 50 kg of Lactway II, and the mixture was sufficiently stirred at a stirring speed of 200 rpm for about 5 hours. After the whole mixture became a uniform mixture, the mixture was dried at 50 ° C. for 48 hours using a shelf-type hot air dryer.
The mixture was dried by heating under reduced pressure for an hour. After the dried product was cooled, it was pulverized with a chopper type pulverizer (2 mm mesh screen). Next, this was sieved to 40 mesh or less by a shifter. Further, the powder having a mesh size of 40 mesh or more was further pulverized by a grinder and crushed, and the pulverized product of the grinder was sieved with a shifter to 40 mesh or less to obtain 91.8 g of a propolis extract powder. .

[0040] Lactose (50 mg) was added to and mixed with the obtained propolis extract powder (200 mg), and the mixture was tableted with a tableting machine to produce a tablet-type propolis processed food. Comparative Example 3 [Production of powdered propolis processed food]

70% aqueous solution of Brazilian propolis extract in ethanol (solid content: 22.4 v / v%) 100K
100 g of a powder of partially decomposed starch containing α-, β- and γ-cyclodextrin (trade name: Dexy Pearl SD-20, manufactured by Saiko Minato Seika Co., Ltd.) was added to the resulting mixture, and the mixture was stirred at a stirring speed of 200 rpm. I do. After that, it was air-dried at 40 ° C. for 1 hour, and ethanol was distilled off. After that, 2 kg of Stevia sweetener (trade name: α-G suite manufactured by Toyo Seika Co., Ltd.)
2 kg of citric acid and 300 kg of anhydrous crystalline maltose were added and mixed well, and the mixture was applied to a granulating machine to produce a granular solid, that is, a powdery propolis processed food. Comparative test result 1 [Comparison of residual amount of ethanol]

Table 2 shows the results of comparing and examining the residual amount of ethanol in each of the processed propolis foods produced in Example 4 and Comparative Examples 1 to 3.

As can be seen from Table 2, the residual amount of ethanol in the hard capsule type propolis processed food of Example 4 was 1
%.

[0044]

[Table 2] Comparative test result 2 [sensory evaluation test]

The results of a sensory test using 15 monitors (5 adult men and 10 adult women) on the ease of drinking each of the processed propolis foods produced in Example 4 and Comparative Examples 1 to 3 were as follows: The results are shown in Table 3. (Each processed food, Example 4, Comparative Example 1 was 4 cap./times, Comparative Example 2 was 6 / times,
Comparative Example 3 ingested 1 g / time with water: in each case, the amount of propolis extract was 60 mg / time).

As can be seen from Table 3, it is found that the hard capsule type propolis processed food of the present invention produced in Example 4 is the easiest to drink.

[0047]

[Table 3] Comparative test result 3 [Disintegration test]

The disintegration of each of the processed propolis foods produced in Example 4 and Comparative Examples 1 to 3 was measured using a disintegration tester (manufactured by Toyama Sangyo Co., Ltd.) based on the 13th revised Japanese Pharmacopoeia Manual. In water (pH 7.0), shaking speed (30 times / mi
n.), 6 capsules for capsules, 6 tablets for tablets, 500 for powders
mg was placed in a shaking gauge, and the disintegration was examined using the time to disintegration as an index.

As shown in Table 4, it can be seen that the processed food of propolis of the present invention produced in Example 4 is very excellent in disintegration.

[0050]

[Table 4]

[0051]

Industrial Applicability According to the present invention, an excellent processed food of propolis extract in which propolis extract is filled in a hard capsule which is easy to drink is provided.

Claims (4)

[Claims] (1) A processed propolis food, wherein a propolis extract powder containing a propolis extract and an excipient is filled in a hard capsule. 2. A propolis process characterized by filling a hard capsule with propolis extract powder and cellulose or / and starch in a weight ratio of 0.01 to 15 parts per part by weight of propolis extract powder. Food. 3. A cellulose having a bulk density of 0.10 g / cm ³ or more and 0.60 g / cm ³ or less and an average particle size of 5 μm or more and 100 μm or less.
The processed propolis food according to claim 2, which is: 4. The processed propolis food according to claim 2, wherein the starch has a moisture content of 2% or more and 20% or less, a viscosity of 2000 cps or more and 5000 cps or less, and an ash content of 5.0% or less.