JP2002186600A - Body fluid collecting device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To collect a body fluid for obtaining a sufficient information in a body while lightening a damage to a skin. SOLUTION: This body fluid collecting device comprises a damage member for damaging a shallow part on a surface of a skin of an organism, and a suction means for sucking the site after damaging of the damage member.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an apparatus for collecting a bodily fluid exudate.

[0002]

2. Description of the Related Art In order to obtain in-vivo information, it is common to collect blood and examine its blood components. However, blood is collected by inserting a needle to a certain depth. Because of the pain and damage that can occur, blood is not easily collected unless necessary. By the way, a method has been proposed that enables measurement of glucose, urea, and the like by detecting body fluid in which components in capillaries, not blood, are filtered by the skin (Jun Kimura et al., BIO INDUSTRY VOL.8). , No. 11, 30-38, 1991).
This method is non-invasive and does not hurt the patient, suggesting use at home. This method discloses a configuration in which the body fluid is collected by aspirating the surface of a living skin, but requires several tens of treatments with an adhesive tape or the like to remove the stratum corneum, which is a barrier layer, and is troublesome. It requires effort.

[0003]

SUMMARY OF THE INVENTION According to the present invention, a combination of a damaged member for damaging a shallow portion of the surface of a living body and suction means for sucking the damaged member after the damage of the damaged member is achieved by a simple operation. The realization of leaching bodily fluid was realized. In other words, the present invention is to vibrate or rotate an abrasive such as a paper file, a short needle, a short blade, or the like, and to abut this on the skin to slightly damage the stratum corneum and a part of the epidermis, Extraction of the exuded bodily fluid was easily realized by aspirating the site.

[0004] The damaged member in the present invention is, for example, a polishing agent containing diamond, corundum, emery, silicon carbide, chromium oxide,
An artificial diamond or the like is fixed to a carrier with an adhesive, a fine needle, a fine blade or the like is fixed to the carrier,
This indicates that this is vibrated up and down or rotated in various directions. Examples of the suction unit in the present invention include a mechanical suction unit such as a suction electromagnetic pump and a physical suction unit such as a molecular sieve. The degree of suction is exemplified by the range shown in the above-mentioned known paper,
In the present invention, since the damage to the stratum corneum is more efficient, the damage may be less than that in some cases, and the intake and drinking time may be shorter than the above-mentioned known paper.

[0005] The present invention is to form an environment in which exudate bodily fluid can be extracted by moderate damage of the stratum corneum first, and then to promote exudation by suction. Moderate damage to the stratum corneum can be obtained by vibrating or rotating each of the above-mentioned fine abrasives, needles, blades or a combination thereof, and in this state, bringing them into contact with the skin surface. Since the degree of contact damage is originally about ten and several microns in the stratum corneum, contact damage may be performed at such a depth, but from the viewpoint of promoting bodily fluid leaching, a further several tens of microns is considered. , Contact damage. The thickness of the stratum corneum is
Different in the human body of each part, also since the fluid leaching amount is different in vivo various locations, sites, is appropriately selected depending on the detected amount.
The contact damage time may be about several seconds in some cases, but is also appropriately selected depending on the body part, the amount of the detected body fluid, and the like.

[0006]

FIG. 1 shows an embodiment of the present invention, which will be described in detail. (A) is a side view showing the side surface in cross section,
(B) is a diagram showing the surface of the carrier on which the abrasive is attached, that is, the bottom surface. In this embodiment, the disk-shaped carrier 11 is formed with the abrasive selected from the above, or the damage means 14 composed of fine needles and blades having a height of about several millimeters, and further, a plurality of suctions for suction. An opening 13B and a suction groove 13A are provided. The surface area of the carrier 11 is selectively used depending on several mm < ² > or less, an adaptation site, a collection amount, and the like. The suction port 13B is provided with a conducting path 13 for suction inside the carrier 11, and at the suction connection end 15, all the conduits 12 are connected.
And is connected to the suction device 18 via. Reference numeral 19 denotes a cover member, which has a concave shape with respect to the skin and has a structure that seals a space including the carrier 11 when coming into contact with the skin.

The suction groove 13A is connected to the suction port 13B when the suction channel 13A is to form a suction path for sucking body fluid around the periphery of the carrier without forming the conduction path 13 inside the carrier. It has a role to increase the suction port ratio on the carrier surface. Either or both of the suction port 13B and the suction groove 13A may be provided. In order to suction the surface of the carrier, the suction area is preferably large, but is appropriately selected within the range of the purpose. Further, the suction port 13B and the suction groove 13A may be effectively used when the leached bodily fluid is held by utilizing the capillary phenomenon. In other words, body fluid exposed to suction, the suction ports, after being held in contact with the suction groove, In this state, be immersed in a buffer solution, is released from the capillary by the buffer, the detection of body fluid This is because it may be completed. Reference numeral 16 denotes a driving unit. The driving means 16 is used for the carrier 1
1 is provided with a configuration for generating driving force such as vibration and rotation, and examples thereof include a combination of a battery, a vibration motor, and a rotation motor. Driving means 16
May be other than such electrical ones, and may use, for example, a compression instantaneous force of a spring such as a mainspring, a leaf spring, or a coil spring. When the vibration operation and the rotation operation at the time of damage are small, the driving means may be moved manually. In the case of vibration drive, the frequency may be higher than that of an ultrasonic wave. In that case, a damaging action with less stimulation is obtained. 161 is a connecting portion for transmitting the driving force generated by the driving means 16 to the carrier 11.

Next, the operation will be described. In use, the surface of the carrier to which the abrasive 14 is attached is brought into contact with the living skin H, and the driving means 16 is used.
Drive. The driving means 16 vibrates or rotates with respect to the skin, for example, in a range of vibration directions A to C. The vibration of A is
A needle is suitable as a means for damaging a living body in the vertical direction. In this case, a needle may be adequately damaged. The vibration of B is caused to vibrate in parallel with the living body. In this case, the blade body may be appropriate as a damaging means. However, when a scratch is formed by an abrasive, the vibration direction B is preferable. It may be. C indicates rotation, and the number of rotations and the direction of rotation are arbitrary, but the faster the rotation, the more preferable the point that the amount of stimulation to the living body can be suppressed. In this case, as the damage means, one coated with an abrasive is preferably used. This vibration or rotation is transmitted to the carrier 11 and damages the skin H. Then, the suction device 18
Is activated, and the skin is sucked from the suction port 13B or the suction groove 13A.

[0009] The suction time depends on the amount of body fluid exuded, the amount to be collected,
Determined by the detection site. In addition, there is a case where the liquid is not sucked, or if the first suction is performed, then the liquid is sufficiently leached, and the suction time is, for example, several seconds to several tens of minutes, but is not particularly limited. The body fluid exposed to the damaged part may be collected by being held by the suction port 13B or the suction groove 13A in addition to being suctioned by another suction tool. When the skin is damaged, the skin may be sucked in advance or may be sucked in the course of the damage, and the body fluid can be obtained more quickly by sucking in advance during the course of the damage.

Also, the present invention provides a method for polishing the skin,
When inhaling, the surface of the living skin can be stretched and damaged more quickly and effectively. Figure 2 shows the configuration for that.
Shown in Reference numeral 21 denotes an extension portion, on which a member having a high friction coefficient such as an adhesive or rubber is arranged on a contact surface with a living body. 2
2 is a connecting part for connecting the carrier 11 and the extension part 21. The connecting portion 22 has a configuration that operates to open outward of the carrier 11 and locks in that state. That is, when attaching the carrier to the living body, the extension portion 21 is attached to the living body, and in this state, the connecting portion 22 is moved outward by pushing the carrier toward the living body, so that the connecting portion 22 moves outward. Accordingly, the skin is also stretched, and when the connecting portion 22 is locked in that state, the skin is also stretched.

Another embodiment of the present invention will be described with reference to FIG. 31 is a porous carrier, which is made of ceramics, metal, wood, etc., the surface of which is constituted by a large number of holes,
It has an overall fine uneven shape. The degree of the diameter of the porous body is preferably large when sucking through the porous carrier 31, while smaller when holding the exposed body fluid, and it is preferable that these are mixed. In some cases. Further, an abrasive may be attached to the surface. 32
Denotes a suction port, and here, a configuration in which suction is performed via the carrier 31 is shown. Reference numeral 33 denotes a cover member, which is formed by a concave member opened toward the skin, and has a structure for forming a closed structure for efficiently sucking the periphery including the carrier. Reference numeral 34 denotes a driving unit, which has the same configuration as the driving unit 16 shown in FIG. Reference numeral 35 denotes a connecting portion, which has a configuration for transmitting the driving force of the driving means 34 to the carrier 31. Reference numeral 36 denotes an opening / closing valve for starting and stopping the suction operation. 37 is a suction means. It has the configuration as described above. Numeral 38 denotes a conduit for connecting the suction means 37, the on-off valve 36, and the suction port 32.

Next, the operation will be described. The surface of the carrier 31 is attached to the surface of the living skin. If the hand-held type is used, the hand-held type can be abutted and hand-mounted, and other types of fixing bands can be used. In some cases, an adhesive material may be applied to the contact surface between the cover member 33 and the living body with an adhesive applied. . In this state, the driving means 34 is driven. The carrier 31 includes the driving means 3
4 vibrates or rotates based on the driving force, and damages the stratum corneum on the skin surface. Since the degree of the damage is caused by the surface shape of the porous material itself, it is preferable because it is relatively soft and causes little damage to a living body. The suction means 37 is driven to open the on-off valve 36, and the skin is sucked through the carrier 32. The exuded bodily fluid is held in the voids of the porous material, and then the carrier 32 is immersed in a buffer solution for the purpose of dilutability, whereby the bodily fluid is released from the carrier 32.

FIG. 4 shows another embodiment. Reference numeral 41 denotes a carrier, which is provided with a concave portion in the center, and is preferably formed of a deformable member such as rubber, and has a damaged portion 42 around which an abrasive, a needle, a blade, or the like is attached. A plurality of suction grooves 43 are provided in a part thereof. Suction groove 43
Has a passageway 44 extending around the carrier 41.
Reference numeral 45 denotes a driving means for exerting a driving force for vibrating and rotating the carrier 46. Reference numeral 46 denotes a cover member which is open in the direction of the living body, and has a configuration for turning right into the living body to seal the space including the carrier and effectively apply the suction force. Reference numeral 47 denotes a suction port for connecting to an external suction means (not shown). As the external suction means, those shown in FIGS. 1 and 2 are referred to.

The operation of the embodiment shown in FIG. 4 will be described. The carrier 41 is brought into contact with the surface of the living skin. At the same time cover member 4
6 is also in contact with the surface of the living skin to form a closed space.
At this time, the concave portion 46 of the carrier has a function of sucking a living body with the deformation of the carrier itself at the time of contact. With this suction force, concentration of body fluid can be promoted. Next, the driving unit 45 is driven, the carrier 41 is driven, and the damaged portion 42 is
Damages the living skin. Activate the suction means,
The part immediately below the damaged part 42 is sucked. Suction is performed through the suction groove 43. By this suction, the exposed body fluid is held in the suction groove 43. In that state, the suction is stopped. Suction groove 43
The body fluid held in the sample is collected, for example, as described above. In this case, it is preferable that the configuration of the suction groove 43 to the carrier can be simplified.

Another embodiment is shown in FIG. Reference numeral 51 denotes a carrier having a triangular pyramid configuration. A suction port 53 is provided at the center, and a damaged portion 52 is formed around the suction port 53.
The suction port 53 is connected to a suction path 54 and is connected to an opening / closing valve (not shown) and suction means (not shown). Numeral 55 denotes a driving means, which is exemplified by a means for electrically or mechanically or manually driving the driving force as described above, but may also have a suction means in some cases. Reference numeral 56 denotes a gripping portion, which is provided mainly for being used by hand.

Next, the operation will be described. Hold the grip 56,
The damaged portion 52 is brought into contact with the surface of the living skin. The driving means 55 is driven. In this case, the driving unit 55 operates to rotate the carrier 54 in parallel with the living body, for example. After the damage operation of the damaged portion 52, the suction means is driven to suck the living body from the suction port 53. After the bodily fluid has leached out, the suction port may hold the bodily fluid in some cases. The present embodiment has a configuration in which the damaged area can be reduced, and the body fluid can be collected more easily.

Next, another embodiment of the present invention will be described with reference to FIG. FIG. 6A is a perspective view, and FIG. 6B is a side view. Reference numeral 61 denotes a cover member having a shape having an opening 66 on a contact surface with a living body, and showing a configuration like an electric razor. The shape of the opening 66 is exemplified by one or more rectangular shapes and circular shapes. Reference numeral 62 denotes a carrier, which operates to rotate in the vertical direction with respect to the living body about the shaft 65. A blade body 64 having a partially helical configuration is mounted on the surface of the carrier 62. This blade 64
Is composed of one or more. Reference numeral 63 denotes a motor, which transmits rotation to the carrier 62 via a transmission member 67. The motor 63 is merely an example, and when continuous rotation is not required, a configuration using an instantaneous force such as a mainspring, a spring coil, or a leaf spring, or a manual drive may be used. Reference numeral 66 denotes an on-off valve, which is a suction means 69
And for aspirating the living body from the opening 66 at the time of opening. In this embodiment, a suction unit 69 and a driving unit 63 may be integrally provided, and the whole may be configured as an electric razor.

Next, the operation will be described. As shown in FIG. 6B, the opening 66 of the cover member 61 is brought into contact with the surface H of the living skin. The motor 63 is driven to rotate the carrier 62. The blade body 64 damages the skin surface slightly protruding from the opening 66. When contacting, depending on the amount of force applied,
The degree of damage is controlled. After the damage, the suction means is driven, the opening / closing valve 68 is opened, and the skin is sucked through the opening 66 to expose the body fluid. The exposed body fluid is collected with a suction device such as a dropper. Although the present embodiment is mainly of a hand-held type, it can be used in such a manner as to use an electric shaver, so that simple use is possible.

[0019]

As described in detail above, the present invention does not need to cause deep damage to the living body, such as blood sampling, and can be used repeatedly, and a sufficient amount of bodily fluid is available to obtain biological information. It has the effect that it can be collected.

[Brief description of the drawings]

FIG. 1 is a diagram showing one embodiment of the present invention.

FIG. 2 is a diagram showing another embodiment of the present invention.

FIG. 3 is a diagram showing another embodiment of the present invention.

FIG. 4 is a diagram showing another embodiment of the present invention.

FIG. 5 is a diagram showing another embodiment of the present invention.

FIG. 6 is a diagram showing another embodiment of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 11 Carrier 12 Conduit 13B Suction port 13A Suction groove 13 Conductive path 14 Damage means 15 Suction connection end 16 Drive means 161 Connecting part 17 Suction opening / closing valve 18 Suction device 19 Cover member

Claims (2)

[Claims] 1. A bodily fluid collection device comprising a damaged member for damaging the surface of a living skin and suction means for sucking the damaged member after the damaged member is damaged. 2. The body fluid sampling device according to claim 1, wherein the damaged member mainly damages the stratum corneum.