JP2002181838A - Dispenser - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a highly durable dispenser capable of dispensing a precise amount of liquid with high reproducibility even when the liquid contains various solid constituents. SOLUTION: A flexible rubber thin film 21 is arranged between an opened face 2 of a vessel 3 and the inside face of a lid 4. On the basis of high flexibility of the rubber thin film 21, the rubber thin film 21 is brought into tight contact with the inside face of the lid 4 without any clearance in supply of the liquid into the inside of the vessel 3, while in dispensing of the liquid from the vessel 3, the rubber film 21 is brought into tight contact with the inside wall face of the vessel 3 without any clearance.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dispensing apparatus for dispensing a fixed amount of liquid into a container, and more particularly, to accurately dispensing a liquid even when dispensing a liquid containing various solid components. The present invention relates to a dispensing device capable of dispensing with high reproducibility and high durability.

[0002]

2. Description of the Related Art Conventionally, various types of dispensers have been used for dispensing a predetermined amount of liquid into a container.

Here, a conventional dispensing apparatus will be described with reference to FIGS. 5 to 7 are explanatory views schematically showing a dispensing apparatus for dispensing liquid using various syringes. In the dispensing apparatus shown in FIG. 5, a normal syringe is used, and the dispensing apparatus shown in FIG. The injection device uses a liquid-filled syringe, and the dispensing device shown in FIG. 7 uses a step-type syringe. FIG. 8 is an explanatory view schematically showing a dispensing apparatus for dispensing a liquid using a peristaltic pump.

[0004] First, in FIG.
A syringe 103 including a syringe container 101 and a piston 102 sliding along the inner wall surface of the syringe container 101
It has. A tube 104 is connected to the lower end of the syringe container 101, and a three-way cock 105 is attached to the tube 104. Three way cock 1
A check valve 107 is interposed in the flow path 106 formed in the inside of the flow path 05.
A check valve 109 is inserted in 8. Here, the check valve 107 allows the liquid to pass in the direction of arrow A,
The check valve 109 has a function of blocking the passage of the liquid in the direction opposite to the direction, and the check valve 109 allows the liquid to pass in the direction of the arrow B, but the liquid in the direction opposite to the direction of the arrow B. Has the function of blocking passage. The flow path 10 of the three-way cock 105
6 is connected to a tube 110,
Is connected to a tube 111. Tube 111
Communicates with a liquid supply (not shown).

When dispensing a liquid with the dispensing device 100, first, the piston 102 is moved in the direction of arrow C (upward). At this time, in the three-way cock 105, the check valve 109 of the branch passage 108 allows the liquid to pass along the direction of arrow B, and the check valve 107 of the flow path 106 allows the liquid to pass in the direction opposite to the direction of arrow A. As described above, when the piston 102 is moved in the direction of arrow C as described above,
From the liquid supply source, liquid is sucked into the syringe container 101 from the tube 111, the check valve 109, the branch passage 108, the flow passage 106, and the tube 104.

After a predetermined amount of liquid has been sucked into the syringe container 101 in this way, the piston 102 is pressed in a direction opposite to the direction of arrow C. At this time, the three-way cock 10
In 5, the check valve 109 of the branch passage 108 blocks the passage of liquid in the direction opposite to the direction of arrow B, and the check valve 107 of the flow path 106 allows liquid to pass in the direction of arrow A. When the piston 102 is depressed in the direction opposite to the direction of arrow C as shown in FIG. 3, the liquid sucked into the syringe container 101 flows through the tube 104, the flow path 106, and the check valve 10.
7. Dispensed into a dispensing container (not shown) via the tube 110.

The dispensing apparatus shown in FIG.
It has the same configuration as the dispensing apparatus 100 shown in FIG. 5, and differs only in the following points. Note that the same members and elements as those of the dispensing apparatus 100 in FIG.

That is, the syringe 103 used in the dispensing apparatus 100 shown in FIG. 5 has a configuration in which the piston 102 slides along the inner wall surface of the syringe container 101 in the syringe 103. The dispensing apparatus 100 shown has a configuration in which a piston 102 having a cylindrical diameter smaller than the cylindrical diameter of the syringe container 101 is used, and a liquid is sealed between the inner wall surface of the syringe container 101 and the outer peripheral surface of the piston 102 with a homogeneous liquid. A syringe 103 is used. Other configurations are the same as those of the dispensing device 100 of FIG.

[0009] The dispensing operation of the dispensing apparatus 100 of FIG. 6 having the above-described structure is similar to that of FIG. 5 in that the outer peripheral surface of the piston 102 in the syringe 103 does not slide along the inner wall surface of the syringe container 101 when dispensing liquid. The other basic operations are the same as those of the dispensing apparatus 100 of FIG.

[0010] Further, the dispensing apparatus shown in FIG.
It has the same configuration as the dispensing apparatus 100 shown in FIG. 5, and differs only in the following points. Note that the same members and elements as those of the dispensing apparatus 100 in FIG.

That is, in the syringe 103 used in the dispensing apparatus 100 shown in FIG. 5, after a single dispensed amount of the liquid is sucked into the syringe container 101, the piston 102 is pressed down to dispense the liquid. However, in the dispensing apparatus 100 shown in FIG. 7, a predetermined number of times (5 in the example shown in FIG. 7).
A predetermined amount of liquid is dispensed for each step by aspirating a liquid corresponding to the dispensed amount of the batch into the syringe container 101 and controlling the amount of depression of the piston 102 in a plurality of steps. A so-called step-type syringe is used. For other configurations, the dispensing device 1 of FIG.
Same as 00.

In the dispensing apparatus 100 of FIG. 7 having the above-described configuration, a liquid corresponding to a plurality of times of dispensing amount is sucked into the syringe container 101 at the time of dispensing the liquid, and the piston 102 is moved in one step. A predetermined amount of liquid is dispensed in a plurality of times corresponding to the pressed amount. Other basic operations at the time of such dispensing operation are described in the dispensing apparatus 1 of FIG.
Same as in 00.

The dispensing device 120 shown in FIG. 8 is different from the dispensing device 100 shown in FIGS. 5 to 7 in which the syringe 103 is used, and is arranged along a concave portion 122 formed in a block 121. The tube 123 is filled with liquid, and the peristaltic pump 1
The tube 123 is rotated by rotating the tube 123 for a predetermined time.
The liquid inside is dispensed into a dispensing container (not shown) by a predetermined amount.

[0014]

According to each of the above dispensing apparatuses, it is possible to dispense a fixed amount of liquid into the dispensing container.

However, in the dispensing apparatus 100 shown in FIG.
Syringe container 1 in syringe 103 when dispensing liquid
Since the inner wall surface of the piston 01 and the outer peripheral surface of the piston 102 slide with respect to each other, when the liquid to be dispensed contains various solid components, the solid component is transferred between the inner wall surface of the syringe container 101 and the piston 102. The slide surface that comes into contact with the outer peripheral surface of the slide. Due to this, there is a problem that the movement of the piston 102 cannot be performed smoothly, and that the component ratio of the solid component contained in the liquid changes.

Further, in the dispensing apparatus shown in FIG. 6, since the liquid-ring type syringe 103 is used, the inner wall surface of the syringe container 101 and the outer peripheral surface of the piston 102 slide when dispensing the liquid. However, the non-volatile liquid 112 sealing between the inner wall surface of the syringe container 101 and the outer peripheral surface of the piston 102 is often mixed with the dispensed liquid,
Therefore, the dispensed liquid cannot be dispensed accurately. In addition, the dispensed amount varies, resulting in poor reproducibility.

Further, in the dispensing device 100 shown in FIG. 7, a plurality of times of liquid is sucked into the syringe container 101,
Since this is dispensed by a predetermined amount in a plurality of steps, the solid component contained in the liquid is dispensed in the syringe container 101.
The solid content in the predetermined amount of liquid dispensed in each step changes due to the tendency to precipitate in the inside. Therefore, it is not possible to accurately dispense a liquid containing a solid component while keeping the solid content constant.

In the dispensing apparatus 120 shown in FIG. 8, the liquid is dispensed by a fixed amount by rotating the peristaltic pump 124 for a predetermined time. However, when the liquid contains a solid component, Due to the characteristic that the liquid is pushed out by the peristaltic pump 124, the solid component may be crushed at the time of dispensing. In addition, the dispensed amount varies, resulting in poor reproducibility.

The present invention has been made to solve the above-mentioned conventional problems. Even when a liquid containing various solid components is dispensed, the liquid dispensed amount can be accurately and reproducibly measured. An object of the present invention is to provide a highly durable dispensing device that can be poured.

[0020]

To achieve the above object, a dispensing apparatus according to claim 1 comprises a container having an open surface;
A lid that closes the open surface and is provided with an air communication portion, a soft extensible thin film (hereinafter, referred to as a “thin film”) disposed between the open surface and the lid, and a cover opposite to the open surface. A dispensing device comprising a liquid flow path continuous with the container body,
When the air in the container body is sucked through the air communication part, the thin film is in close contact with the inner surface of the lid, and the liquid flows into the container body through the liquid flow path, and the air communication part When the air is introduced into the container via the, the thin film is in close contact with the inner wall surface of the container, and the liquid in the container is discharged through the liquid flow path.

In the dispensing device according to the first aspect, a thin film is disposed between the open surface of the container and the lid, and the thin film disperses air in the container through the air communication portion of the lid. When aspirating and causing the liquid to flow into the container from the liquid flow path of the container, the liquid is brought into close contact with the inner surface of the lid, and air is introduced into the container through the air communication portion, and the liquid in the container is removed. When it is discharged from the fluid flow path, it is brought into close contact with the inner wall surface of the container. As described above, the thin film is formed between the inner surface of the lid and the inner wall surface of the container when the liquid is sucked into the container and when the liquid in the container is discharged and dispensed, based on the flexibility. Thus, it is possible to closely contact all surfaces that determine a predetermined volume without any gap. Therefore, a predetermined amount of liquid can always be accurately suctioned into the container body,
As a result, a predetermined amount of liquid can always be accurately dispensed with good reproducibility. Further, the dispensing device does not have any portion that slides when dispensing liquid, so that high durability can be maintained.

A dispensing device according to a second aspect of the present invention is the dispensing device according to the first aspect, wherein the liquid contains a solid component. The dispensing apparatus according to claim 2, wherein the solid component is erythrocytes or gelatin particles (Japanese Patent Application Laid-Open No. 57-153658).
), Gelatin magnetic particles (JP-A-59-19516).
No. 1), ferrite magnetic particles (JP-A-3-1158)
No. 62) or latex particles. In the dispensing device of claims 2 and 3, the liquid to be dispensed contains solid components such as erythrocytes, gelatin particles, gelatin magnetic particles, ferrite magnetic particles, and latex particles. As described above, the dispensing apparatus does not have any portion that slides when dispensing the liquid, so that the solid component is not crushed during dispensing.Therefore, the content ratio of the solid component in the liquid is reduced. It is possible to dispense while always maintaining a constant.

Furthermore, a dispensing device according to a fourth aspect is the dispensing device according to any one of the first to third aspects, wherein the thin film is formed of latex, natural rubber, or synthetic rubber. And In the dispensing device according to the fourth aspect, the thin film is formed from latex, natural rubber or synthetic rubber, and the thin film formed from these materials has high flexibility. Therefore, when the liquid is sucked into the container and when the liquid in the container is discharged and dispensed,
It is possible to adhere without any gap to all surfaces that define a predetermined volume formed between the inner surface of the lid and the inner wall surface of the container, and a predetermined amount of liquid can always be accurately dispensed. .

According to a fifth aspect of the present invention, in the dispensing apparatus according to any one of the first to fourth aspects, the air communication portion has an air suction hole for sucking air inside the container body. An air introduction hole for introducing air into the container body, wherein a filter member is interposed between the air suction hole and the air introduction hole and the thin film, and A dispensing apparatus according to a sixth aspect is the dispensing apparatus according to claim 5, wherein the filter member is formed of a porous resin material. In the dispensing device according to the fifth and sixth aspects, a filter member formed of a porous resin material is interposed between the thin film and the air suction hole and the air introduction hole that form the air communication portion in the lid. Therefore, when the air is sucked from the inside of the container through the air suction hole and when the air is introduced into the inside of the container through the air introduction hole, the suction pressure and the introduction pressure of the air are locally applied to the thin film. It is possible to reliably prevent a strong and partial action from acting, thereby preventing the thin film from being damaged.

[0025]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, a dispensing apparatus according to the present invention will be described in detail based on an embodiment embodying the present invention with reference to the drawings. First, the dispensing apparatus according to the present embodiment will be described with reference to FIGS. 1 is a side sectional view schematically showing a dispensing device in a state where liquid is sucked and filled in a container, and FIG. 2 is a dispensing device in a state after dispensing a liquid filled in a container. It is a side sectional view which shows typically.

In FIGS. 1 and 2, the dispensing apparatus 1 basically includes a container 3 having an open surface 2 at an upper portion, and a lid 4 for closing the open surface 2 of the container 3.

Here, the container 3 basically has a cylindrical portion 5, a flange portion 6 integrally formed horizontally and continuously from the upper edge of the cylindrical portion 5, and a lower portion of the cylindrical portion 5. It is formed integrally with a bottom portion 7 which is continuous with the edge portion and is inclined toward the center portion. A liquid flow hole 8 is formed in the center of the bottom 7, and the liquid flow hole 8 communicates with a liquid flow path 10 formed in a flow path tube 9 formed continuously below the bottom 7. ing. A branch tube 11 is provided on one side of the flow tube 9, and a branch channel 12 of the branch tube 11 communicates with the liquid flow channel 10. A first check valve 13 is inserted below the branch tube 11 in the flow passage tube 9, and a second check valve 14 is inserted into the branch tube 11. I have.
The first check valve 13 allows the liquid to pass in the direction of the arrow A in the channel tube 9, while blocking the passage of the liquid in the direction opposite to the direction of the arrow A. Suga 11
Performs the function of blocking the passage of the liquid in the direction opposite to the direction of arrow B while allowing the liquid to pass in the direction of arrow B.

In the container 3, an inner wall surface 6B at a connecting portion 6A between the cylindrical portion 5 and the flange portion 6 and an inner wall surface 7B at a connecting portion 7A between the cylindrical portion 5 and the bottom portion 7 are both formed into curved surfaces. Have been.

Further, the lid 4 is provided with an air introduction hole 15 for introducing compressed air into the container 3, and the air introduction hole 15 is continuous with the air introduction tube 16. Further, an electromagnetic valve 17 is interposed in the air introduction tube 16. The solenoid valve 17 is turned on when introducing the compressed air into the container 3 to open the air introduction tube 16, and is turned off when the introduction of the compressed air is stopped to close the air introduction tube 16. still,
A small compressor (not shown) is provided in the air introduction tube 16.
The compressed air is introduced into the air introduction tube 16 in the direction of arrow C via the compressor. At this time, the compressed air is compressed to, for example, about 1.3 atm through the compressor. This air pressure can be changed as appropriate according to the material or thickness of the rubber thin film 21.

The lid 4 is provided in parallel with the air introduction tube 16,
An air suction hole 18 for sucking and discharging air in the container 3 is provided, and the air suction hole 18 is continuous with an air suction pipe 19. Further, a valve 20 is inserted in the air suction tube 19. The valve 20 is opened when the air existing in the container 3 is sucked and discharged, and the air suction pipe 19 is opened.
When the air suction is stopped, the air suction pipe 19 is closed and the air suction pipe 19 is closed. It should be noted that a small suction pump (not shown) is connected to the air suction pipe 19, and air is sucked and discharged from the air suction pipe 19 in the direction of arrow D via this suction pump. At this time, the air is sucked and discharged at, for example, about 0.8 atm through the suction pump. This pressure is
It can be changed as appropriate according to the material or thickness of the rubber thin film 21.

Along the open surface 2 of the container 3, a rubber thin film 21 is disposed between the upper surface of the flange portion 6 and the lower surface of the lid 4 in the container. The rubber thin film 21 is made of a material such as latex, natural rubber, or synthetic rubber to a thickness of 0.5 mm.
mm to 0.01 mm, for example, about 0.03 mm, and has high followability (flexibility). As described later, the rubber thin film 21 is used for the air suction tube 1.
When the air in the container 3 is sucked and discharged through the container 9 to flow the liquid into the container 3, the air is tightly adhered to the inner surface of the lid 4 without any gap, and the compressed air is supplied to the container 3 through the air introduction tube 16. When the liquid is introduced into the container 3 and discharged from the liquid channel 10 of the channel tube 9, the liquid in the container 3 is brought into close contact with the inner wall surface of the container 3 without any gap.

A filter member 22 is interposed between the rubber thin film 21 and the air introduction hole 15 and between the rubber thin film 21 and the air suction hole 18. The filter member 22 is formed from a porous material such as a porous resin material. The filter member 22 is provided with the air suction hole 18.
When air is sucked from the inside of the container 3 through the air inlet and when air is introduced into the container 3 through the air introducing hole 15,
The function of reliably preventing the air suction pressure or the introduction pressure from acting locally or partially on the rubber thin film 21 is ensured. This can prevent the rubber thin film 21 from being damaged.

A liquid supply tube 23 is connected to the branch tube 11, and the liquid supply tube 23 communicates with a liquid supply source 24 for storing a liquid to be dispensed. The liquid stored in the liquid supply source 24 is, as described later,
When the air in the container 3 is sucked and discharged through the air suction pipe 19, the liquid is supplied into the container 3 from the liquid supply tube 23, the branch tube 11, and the second check valve 14 through the liquid flow path 10 of the flow path tube 9. Supplied. Here, the liquid stored in the liquid supply source 24 is
It contains solid components such as erythrocytes, gelatin particles, gelatin magnetic particles, ferrite magnetic particles, and latex particles. In addition, a dispensing container 25 is arranged below the channel tube 9.

Next, the operation of the dispensing apparatus 1 configured as described above will be described with reference to FIGS. here,
It is assumed that the dispensing apparatus 1 is initially in the state shown in FIG. FIG. 2 shows a state after the liquid that has flowed into the container 3 is discharged from the liquid flow path 10 of the flow path tube 9 in the direction of arrow A and dispensed. This corresponds to the state before the liquid flows in. In the state shown in FIG. 2, the electromagnetic valve 17 is opened and compressed air is introduced into the container 3 from the compressor via the air introduction tube 16, and the rubber thin film 21 is released based on the pressure of the compressed air. It is closely attached to the inner wall surface of the container 3 without any gap. At this time,
Since the inner wall surface 6B of the connecting portion 6A and the inner wall surface 7B of the connecting portion 7A in the container 3 are both formed as curved surfaces,
It is possible to reliably prevent wrinkles and the like from occurring in the rubber thin film 21 at the inner corner portion of the container 3. Thereby, the rubber thin film 21 can be brought into close contact with the inner wall surfaces 6B and 7B without any gap.

In the state shown in FIG. 2, first, the electromagnetic valve 17 is turned off to close the air introducing tube 16 and the valve 20 is closed.
To open the air suction tube 19. Thereby, the air in the container 3 is sucked and discharged in the direction of arrow D via the air suction holes 18 and the air suction pipe 19. When the air in the container 3 is suctioned and discharged as described above, the liquid stored in the liquid supply source 24 is supplied to the liquid supply tube 23, the branch tube 11, the second check valve 14, and the like.
Is supplied into the container 3 through the liquid flow passage 10 of the flow passage tube 9. Further, the rubber thin film 21 moves away from the inner wall surface of the container 3 with the supply of the liquid into the container 3.

When the valve 20 is opened for a predetermined time, the container 3 is filled with a predetermined amount of liquid as shown in FIG. 1, and the rubber thin film 21 is placed on the inner surface of the lid 4. Close contact without gaps. At this time, the volume of the container 3 is determined by the space formed between the inner wall surface of the container 3 and the inner surface of the lid 4, and the rubber thin film 21 is provided on all surfaces that determine the volume of the container 3. Because it is possible to adhere without gaps,
A predetermined amount of liquid can always be accurately suctioned into the container 3.

After filling the container 3 with a predetermined amount of liquid as described above, the valve 20 is closed and the air suction pipe 19 is closed, and the solenoid valve 17 is turned on to open the air introduction pipe 16. You. When the solenoid valve 17 is opened, compressed air is introduced into the container 3 through the air introduction tube 16 and the air introduction hole 15. With the introduction of the compressed air into the container 3, the rubber thin film 21 is separated from the inner surface of the lid 4, and the liquid in the container 3 passes through the liquid flow hole 8 and the liquid flow path of the flow path tube 9. 10, it flows down in the direction of arrow A via the first check valve 13. Thus, the liquid in the container 3 is dispensed into the dispensing container 25.

When the electromagnetic valve 17 is turned on for a predetermined time, a predetermined amount of liquid in the container 3 is dispensed into the dispensing container 25. At this time, as shown in FIG.
Since the liquid is tightly adhered to the inner wall surface of the container 3 without any gap, the predetermined amount of liquid filled in the container 3 can be accurately dispensed to the dispensing container 25 as described above.

As described above, in the dispensing apparatus 1 according to the present embodiment, the flexible rubber thin film 21 is disposed between the open surface 2 of the container 3 and the inner surface of the lid 4 and the rubber thin film 21 Based on the high flexibility, the rubber thin film 21 is brought into close contact with the inner surface of the lid 4 when the liquid is supplied into the container 3 without any gap, and the rubber thin film 21 is dispensed with the container 3 when dispensing the liquid from the container 3. Since the rubber thin film 21 is configured to be tightly attached to the inner wall surface without any gap, the rubber thin film 21 can be tightly fitted to all surfaces that determine the volume of the container 3 without any gap. Thus, a predetermined amount of liquid can always be accurately dispensed with good reproducibility. In addition, the dispensing device 1 has no sliding portion at the time of dispensing liquid, so that high durability can be maintained.

The liquid to be dispensed contains solid components such as red blood cells, gelatin particles, gelatin magnetic particles, ferrite magnetic particles, and latex particles. Since there is no sliding part at all, the solid component is not crushed during dispensing. Therefore, it is possible to dispense while always keeping the content ratio of the solid component in the liquid constant.

Further, the rubber thin film 21 is formed of a material having extremely high flexibility such as latex, natural rubber, synthetic rubber and the like, and is used for sucking and flowing the liquid into the container 3 and for controlling the liquid in the container 3. When discharging and dispensing, cover 4
It is possible to tightly contact all surfaces defining the predetermined volume formed between the inner surface of the container 3 and the inner wall surface of the container 3 without gaps, and a predetermined amount of liquid can always be accurately dispensed.

A filter member 22 made of a porous material such as a porous resin is provided between the rubber thin film 21 and the air introduction hole 15 and between the rubber thin film 21 and the air suction hole 18. In particular, when the compressed air is introduced into the container 3 from the air introduction tube 16, dust and the like contained in the compressed air can be reliably removed,
Thereby, the inside of the container 3 can be always kept clean.

In the dispensing apparatus 1 according to the embodiment,
The shape of the container 3 is a cylindrical shape having a cylindrical portion 5, and an inner wall surface 6B at a connecting portion 6A between the cylindrical portion 5 and the flange portion 6 and an inner wall surface 7B at a connecting portion 7A between the cylindrical portion 5 and the bottom portion 7 are formed.
Are formed in a curved surface, but the present invention is not limited to this, and the entire container 3 may be formed in a hemispherical shape as shown in FIG. By forming the container 3 in a hemispherical shape in this way, the entire inner wall surface of the container 3 has a smooth curved surface. As a result, when the liquid in the container 3 is discharged and dispensed, the rubber thin film 21 is removed. 3 can be very easily adhered to the inner wall surface.

Next, a dispensing system in which a plurality of dispensing apparatuses are integrated will be described with reference to FIG. FIG. 4 is an explanatory diagram schematically showing the dispensing system. The dispensing system 30 shown in FIG. 4 has a block body 32 in which a plurality of (four in FIG. 4) quantitative sections 31 are formed, and is disposed on the entire upper surface of the block body 32 so as to cover the open surface of each quantitative section 31. And a lid 34 disposed on the upper surface of the rubber thin film 33. The lid 34 has an air introduction tube 35 for introducing compressed air corresponding to each of the quantification sections 31 and the quantification section 3.
An air suction pipe 36 for sucking and discharging the air in the inside 1 is provided.

Further, from the lower part of each of the quantification sections 31, the flow tube 3
7 are formed, and a three-way cock 38 is provided in each channel tube 37.
Is inserted. A branch tube 39 is connected to each three-way cock 38. Here, the three-way cock 38 is
7, the liquid is allowed to pass in the direction of arrow A.
In the direction opposite to the direction, the passage of the liquid is blocked, and in the branch tube 39, the liquid is passed in the direction of arrow B, while the passage of the liquid in the direction opposite to the direction of arrow B is blocked.

Each branch tube 39 is joined to a liquid supply tube 40, and one end of the liquid supply tube 40 is immersed in the liquid stored in the liquid supply source 41. still,
A dispensing container 42 is arranged below each channel tube 37.

Next, the liquid dispensing operation in the dispensing system 30 will be described. At first, it is assumed that compressed air is introduced into each metering section 31 from each air inlet tube 35, and the rubber thin film 33 is in close contact with the inner wall surface of each metering section 31.

In order to dispense the liquid from the liquid supply source 41 to each dispensing container 42 in this state, first, each air introduction tube 35
After closing the air suction pipes 36, the air suction pipes 36 are opened and
The air inside is sucked and discharged. Thereby, the liquid supply source 41
The liquid stored therein is sucked from the common liquid supply tube 40 into each of the branch tubes 39 along the direction of arrow B, and is supplied into the metering unit 31 via the three-way cock 38. Along with this, the rubber thin film 33 that has been in close contact with the inner wall surface of each of the quantification units 31 separates from the inner wall surface of the quantification unit 31.

At the time when air is sucked from each air suction pipe 36 for a predetermined time, a predetermined amount of liquid flows into and fills each of the metering sections 31 as shown in FIG. Is tightly attached to the inner surface of the lid 34 without any gap. At this time, the volume of each quantitative unit 31 is determined by the space formed between the inner wall surface of the quantitative unit 31 and the inner surface of the lid 4,
Since the rubber thin film 33 can be in close contact with all surfaces that determine the volume of the fixed quantity section 31 without gaps, a predetermined amount of liquid can always be drawn into each fixed quantity section 31 accurately.

After a predetermined amount of liquid has been filled into each of the metering sections 31 as described above, the air suction pipes 36 are closed, and the respective air introduction pipes 35 are opened to allow the compressed air to flow into the respective metering sections 31. It is introduced into the container 3. With the introduction of the compressed air into the metering sections 31, the rubber thin film 21 is separated from the inner surface of the lid 4, and the liquid in each metering section 31
It flows down in the direction of arrow A via each three-way cock 38 and the flow path tube 37. As a result, the liquid in each metering unit 31 is simultaneously dispensed into each dispensing container 42. At this time, since the rubber thin film 33 is closely attached to the inner wall surface of each metering section 31 without any gap, the predetermined amount of liquid filled in each metering section 31 as described above is accurately transferred to each dispensing container 42. Can be dispensed.

As described above, according to the dispensing system 30, the flexible rubber thin film 33 is disposed between the open surface of each of the metering portions 31 formed on the block 32 and the inner surface of the lid 34. Based on the high flexibility of the rubber thin film 33, the rubber thin film 33 is brought into close contact with the inner surface of the lid 34 without any gap when the liquid is supplied into each of the quantification sections 31, and the liquid from within each of the quantification sections 31 Is configured such that the rubber thin film 33 is closely adhered to the inner wall surface of each metering section 31 without gaps when dispensing.
It is possible to closely contact all the surfaces that determine the volume of No. 1 without any gap. Thus, a predetermined amount of liquid can always be accurately dispensed with good reproducibility. In addition, the dispensing system 30 does not have any parts that slide when dispensing liquid, so that high durability can be maintained.

Further, a plurality of metering portions 31 are formed in one block body 32, and a branch tube 39 communicating with a three-way cock 38 inserted in each channel tube 37 is connected to the liquid supply tube 4.
Since the merging is performed at 0, the operation of supplying the liquid to each quantitative unit 31 and the operation of dispensing the liquid from each quantitative unit 31 to the dispensing container 42 can be performed simultaneously for the plurality of quantitative units 31. Thus, the present invention can be applied to an inspection apparatus or the like that performs an inspection on a large number of sample samples containing various solid components at the same time.

It should be noted that the gist of the present invention is not limited to the above embodiment, and it is needless to say that improvements and modifications can be made without departing from the gist of the present invention.

[0054]

In the dispensing device according to the first aspect, the soft extensible thin film is disposed between the open surface of the container and the lid, and the thin film is provided through the air communication portion of the lid. When the air in the container is sucked and the liquid flows into the container from the liquid flow path of the container, the air is brought into close contact with the inner surface of the lid, and the air is introduced into the container via the air communication portion, When the liquid in the container is discharged from the fluid flow path, the liquid adheres to the inner wall surface of the container. As described above, the thin film is formed between the inner surface of the lid and the inner wall surface of the container when the liquid is sucked into the container and when the liquid in the container is discharged and dispensed, based on the flexibility. Thus, it is possible to closely contact all surfaces that determine a predetermined volume without any gap. Therefore, a predetermined amount of liquid can always be accurately suctioned into the container, and as a result, a predetermined amount of liquid can always be accurately dispensed with good reproducibility. Further, the dispensing device does not have any portion that slides when dispensing liquid, so that high durability can be maintained.

Further, in the dispensing apparatus according to the second and third aspects, the liquid to be dispensed contains solid components such as erythrocytes, gelatin particles, gelatin magnetic particles, ferrite magnetic particles, and latex particles. However, even in such a case, as described above, the dispensing device does not have a sliding portion at the time of dispensing the liquid, so that the solid component is not crushed at the time of dispensing. It is possible to dispense while always keeping the content ratio of the components constant.

Further, in the dispensing device according to the fourth aspect, the thin film is formed of latex, natural rubber or synthetic rubber, and the thin film formed of these materials has high flexibility. Therefore, when the liquid is sucked into the container body and when the liquid inside the container body is discharged and dispensed, the predetermined volume formed between the inner side surface of the lid and the inner wall surface of the container body is defined on all surfaces. Adhesion can be made without gaps, and a predetermined amount of liquid can always be accurately dispensed.

Further, in the dispensing apparatus according to the fifth and sixth aspects, the lid is formed of a porous resin material between the air suction hole and the air introduction hole constituting the air communication portion and the thin film. Since the filter member is interposed, when suctioning air from the inside of the container through the air suction hole and when introducing air into the container through the air introduction hole, the air suction pressure and the introduction pressure are thin. Can be reliably prevented from acting locally or partially on the thin film, thereby preventing the thin film from being damaged.

[Brief description of the drawings]

FIG. 1 is a side sectional view schematically showing a dispensing apparatus according to an embodiment in a state where a liquid is suctioned and filled in a container.

FIG. 2 is a side sectional view schematically showing the dispensing device according to the present embodiment in a state after dispensing a liquid filled in a container.

FIG. 3 is a side sectional view schematically showing another example of a dispensing device in which a container is formed in a hemispherical shape.

FIG. 4 is an explanatory view schematically showing a dispensing system.

FIG. 5 is an explanatory view schematically showing a conventional dispensing device using a normal syringe.

FIG. 6 is an explanatory view schematically showing a conventional dispensing device using a liquid-filled syringe.

FIG. 7 is an explanatory view schematically showing a conventional dispensing device using a step-type syringe.

FIG. 8 is an explanatory view schematically showing a conventional dispensing apparatus for dispensing a liquid using a peristaltic pump.

[Explanation of symbols]

 REFERENCE SIGNS LIST 1 dispensing device 2 open surface 3 container 4 lid 8 liquid flow hole 9 flow passage tube 10 liquid flow passage 11 branch tube 13 first check valve 14 second check valve 15 air inlet 16 air inlet 18 air suction hole 19 Air suction tube 21 Rubber thin film 22 Filter member 23 Liquid supply tube 24 Liquid supply source 25 Dispensing container

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Hiromichi Tsuchiya 2-62-5 Nihonbashi-Hamacho, Chuo-ku, Tokyo F-Termio, Fujirebio Inc. F-term (reference) 2G058 EA03 EB00 ED17 3H075 AA01 BB04 CC11 CC18 DA05 DA21 DB10 DB42 3H077 AA01 CC02 CC09 DD09 DD14 EE05 EE23 FF08 FF60 4G068 AA02 AA03 AA07 AB11 AB17 AC17 AD11 AD36 AD40 AD47 AE03 AF07

Claims (6)

[Claims] 1. A container having an open surface, a lid closing the open surface and provided with an air communication portion, and a soft extensible thin film (hereinafter referred to as a thin film) disposed between the open surface and the lid. , A “thin film”), and a liquid flow path connected to the container body on the side opposite to the open surface, wherein the air in the container body is sucked through the air communication part. When the thin film is in close contact with the inner surface of the lid and liquid flows into the container through the liquid flow path, and when air is introduced into the container through the air communication portion, the thin film Is a dispensing device, wherein the liquid is in close contact with the inner wall surface of the container body and the liquid in the container body is discharged through a liquid flow path. 2. The dispensing apparatus according to claim 1, wherein the liquid contains a solid component. 3. The dispenser according to claim 2, wherein the solid component is red blood cells, gelatin particles, gelatin magnetic particles, ferrite magnetic particles or latex particles. 4. The thin film is formed of latex, natural rubber or synthetic rubber.
A dispensing device according to any one of claims 1 to 3. 5. The air communication section has an air suction hole for sucking air inside the container body, and an air introduction hole for introducing air into the container body, wherein the air suction hole and the air introduction are provided. The dispensing device according to any one of claims 1 to 4, wherein a filter member is interposed between the hole and the thin film. 6. The dispensing device according to claim 5, wherein the filter member is formed of a porous resin material.