JP2002058450A - Food product for antidepression - Google Patents

Food product for antidepression

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JP2002058450A
JP2002058450A JP2000287752A JP2000287752A JP2002058450A JP 2002058450 A JP2002058450 A JP 2002058450A JP 2000287752 A JP2000287752 A JP 2000287752A JP 2000287752 A JP2000287752 A JP 2000287752A JP 2002058450 A JP2002058450 A JP 2002058450A
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food
depression
antidepression
anti
food product
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Japanese (ja)
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Nozomi Otake
Takeshi Otake
Hei Sai
Kinji Takada
剛 大岳
望 大岳
兵 蔡
欣二 高田
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(有)日本バイオメディカル研究所
Nippon Biomedical Kenkyusho:Kk
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Abstract

PROBLEM TO BE SOLVED: To provide a highly safe food product for antidepression excellent in antidepressant effect without spoiling the food taste. SOLUTION: This food product for antidepression is characterized by containing powder or an extract of at least one food material selected from the group consisting of (a) spices mainly comprising hop extract, (b) licorice, (c) Ligusticum acutilobum, (d) roots of Oenanthe stolonifera, and (e) mushrooms and having antidepressant effect.

Description

【発明の詳細な説明】 【0001】 【産業上の利用分野】本発明は、精神分裂病、うつ病などの疾患に有効な抗うつ病用組成物に係り、さらに詳しくは、食品の味を損なわない抗うつ病用食品に関するものである。 BACKGROUND OF THE INVENTION [0001] Field of the Invention The present invention, schizophrenia, relates to effective anti-depressive composition for diseases such as depression, more particularly, the taste of the food the present invention relates to anti-depression for food that does not impair. 【0002】 【従来の技術】近年、元気がなくなる「感情の病」で一般的に社会適応もよく、一旦挫折を体験して陥る病態いわゆる「うつ病」の人が増え、四十代および五十代の人に発症しやすいと云われている。 [0002] In recent years, may be generally social adjustment in the spirit there is no "feeling of illness", more and more once the people of the fall to experience the frustration pathology so-called "depression", 40s and five to the people of teens are said likely to develop. うつ病は、精神疾患のなかで現代病といえるもので、また極めて普通の病気である。 Depression is, but it can be said that the modern disease among the mental disorders, also is a very common disease. ごく軽いうつ病ならば、一種の「心のカゼ」のように、しかも自殺の危険性を秘めているから、専門医に早期受診して欲しいものである。 If the very light depression, as a kind of "heart of the cold", moreover because they concealed the risk of suicide, is what you want to early visits to specialists. 思考力減退、悲観的、 Thinking ability decline, pessimistic,
不安感、不眠、劣等感、後悔、ぐちっぽい、心配症、自殺念慮、をもち、深刻な社会問題にまで発展している。 Anxiety, insomnia, inferiority complex, regret, querulous, anxious, suicidal ideation, have, have developed into a serious social problem. 【0003】そこで、うつ病の治療についての研究が広くなされており、医療品の開発も盛んである。 [0003] Therefore, have been made widely studied for the treatment of depression, the development of medical products is also thriving. 医療用医薬品のほか生薬も普及している。 It is also popular addition to herbal medicine of prescription drugs. 最近この漢方療法の研究が注目されている。 A study of this traditional Chinese medicine therapy has been attracting attention recently. 黄連解毒湯、半夏厚朴湯、柴朴湯、茯苓飲合半夏厚朴湯、桃核承気湯、加味帰脾湯、三黄瀉心湯、苓桂甘棗湯、桂枝加龍骨牡蠣湯、女神散、温胆湯、加味温胆湯、大柴胡湯、柴胡桂枝乾姜湯、半夏瀉心湯、苓桂朮甘湯、抑肝散、温清飲、柴胡清肝湯、抑肝散加陳皮半夏、温経湯、大承気湯、加味越婢湯、真武湯、四逆散、柴胡加龍骨牡蠣湯などを挙げることができる。 Orengedokuto, Han'natsu magnolia bark hot water, saibokuto, 茯苓 drinking if Han'natsu magnolia bark hot water, Momokaku Uketamawakiyu, taking into account the null 脾湯, three yellow 瀉心 hot water, 苓桂 Amanatsume hot water, Keishi-pressure Ryukotsu oyster hot water, goddess distributed , Yutakatan'yu, taking into account temperature Tan'yu, Oshiba saiko, saiko Katsura Edainui Kyoyu, half summer 瀉心 hot water, 苓桂 Atractylodes Amayu, yokukansan, YutakaKiyoshiin, Shiba EbisuKiyoshi Kan'yu, depression liver underground chenpi half the summer, Yutakakeiyu, large Uketamawakiyu, consideration Yue 婢湯, Mabuyu, four reverse dispersion, and the like Saiko pressurized Ryukotsu oyster water. 漢方療法は天然物由来の生薬を用いている、若干遅効性ではあるものの、体質改善も、薬効が全身にわたるという利点がある。 Kampo therapy uses a crude drug derived from natural products, although some is a slow-acting, extender improved, there is an advantage that medicinal spans the whole body. 西洋医薬に比べ副作用が少なく比較的に長期にわたって服用しても安全性が高い。 Even taking over relatively long fewer side effects compared with Western medicine has high safety. 【0004】上記漢方療法に用いられる漢方薬としては柴胡、半夏、黄苓、大棗、枳實、生姜、大黄、甘草、などの生薬が含まれている。 [0004] As a herbal medicine used for the above-mentioned Chinese medicine therapy Saiko, half summer, Ki苓, Dainatsume, 枳實, ginger, rhubarb, are included herbal medicine of licorice, such as. これらの漢方薬は顆粒、錠剤等の形態で用いられているが、特有の苦い味があったり、後味が悪かったりすることが多いので内服しづらいという欠点があった。 These herbal medicines granules have been used in the form of tablets or the like, has a drawback that or have bitter peculiar taste, difficult ingest because often aftertaste or bad. そこで、ホップと漢方薬中の構成生薬成分をガム、キャンデー、飲料などのような食品の形で提供すれば、内服しやすくのではないかと研究に着手した。 Thus, the configuration herbal components in the hop and herbal medicine gum, candy, if provided in the form of food products such as beverages, set out to research that it would be easy to ingest. しかしながら、ホップは長年ビールの苦味成分として使われ、食品として認められており、その生理作用を調べた結果、抗うつ病効果があることが判明した。 However, hops are used as a bitter component of long beer, it has been recognized as a food, as a result of investigating the physiological effects, it was found that there is an anti-depressive effect.
これに従来食品添加物として認められている鎮静作用をもつ生薬成分をガム、キャンデー、飲料などに添加することを特徴としている。 It is characterized by the addition of herbal ingredients with sedation is observed as the conventional food additives gum, candy, etc. to a beverage. 【0005】 【発明が解決しようとする課題】本発明は、このような事情に鑑みなされたものであって、その目的とするところは、抗うつ病の効果に優れ、安全性が高く、しかも、 [0005] [0008] The present invention was made in view of such circumstances, it is an object of excellent antidepressant effect, high safety, yet ,
食品の風味を損なわない抗うつ病用食品を提供するにある。 It is to provide an anti-depression for food that does not impair the flavor of the food. 【0006】 【課題を解決するための手段】上記の目的は、下記の群から選ばれたすくなくとも一つの食品素材の粉末またはエキスを含有し、うつ病に対して抗うつ病作用を有することを特徴とする抗うつ病用食品によって達成される。 [0006] [Means for Solving the Problems] The above object, containing at least one food material of powder or extract selected from the following group, that have anti-depressive effect on depression It is achieved by an anti-depressive food characterized. a)ホップ、コリアンダー、セリの根、胡椒、クローブ(丁字)、ミント(薄荷)、菊花およびきのこ類b)バラ科の果実c)ユリ科の球根d)昆布からなる群より選ばれる少なくとも一つの香辛料またはハーブ。 a) hops, coriander, parsley roots, pepper, cloves (clove), mint (peppermint), chrysanthemum and mushrooms b) Rosaceae fruit c) Liliaceae bulbs d) at least one selected from the group consisting of kelp spices or herbs. すなわち、本発明者らは、従来からの食品に用いられている種々の食品素材のなかから抗うつ病機能を有する食品素材をスクリーニングする方法がないかと考え、検討を行った。 That is, the present inventors considered that if there is a method of screening for food material having antidepressant function from among various food materials used in the food from conventionally investigated. その結果、Narita,K. As a result, Narita, K. ,N , N
ishihara,M. ishihara, M. ,Takahashi,M. , Takahashi, M. :
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to,Y. to, Y. ,Nishihara,M. , Nishihara, M. ,Takaha , Takaha
shi,M. shi, M. :[VMH Lesions Reduc : [VMH Lesions Reduc
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EHAV. EHAV. 66(5),803−808(1999)の報告した方法を食品素材のホップに応用したところ、蔡兵:「ホップのマウス運動量に対する影響」(発表準備中)からもわかるようにうつ病マウスの運動量はうつ病の成立により、増加してきたところ、ホップの成分をえさに混ぜ飼育しているところ、運動量が減少してきたことがわかり、これらの結果は抗うつ病効果に優れ、かつ食品の味を損なわないような食品が得られることを確認し、本発明を完成した。 66 (5), 803-808 where the report was the method (1999) was applied to the hop of food materials, 蔡兵: "effects on mouse movement amount of hops" (announced in preparation) from depression mouse as can be seen the momentum established depression, where has increased, where are bred mixed ingredients hops food, see that the momentum has been decreased, the taste of these results is excellent in anti-depressive effect, and food Make sure that the food that does not impair the obtained, and have completed the present invention. 【0007】次に本発明を詳しく説明する。 [0007] Next, the present invention will be described in detail. 抗うつに関する治療は正確な診断を加え、薬物療法(例えばイミプラミンで1日10〜25mg程度数ケ月続けると効果が見られることがある。)、休息のほか、改善に向かわせるような精神面、環境面の配慮も必要である。 Treatments for antidepressant is an accurate diagnosis addition, (continuing several months about one day 10~25mg for example imipramine may effect is seen.) Drug therapy, in addition to rest, mental as to direct improvement, consideration of environmental aspects is also required. 抗うつ薬の投与による意欲亢進により、自殺傾向も亢進してしまう場合があるので食事面で薬物治療をうけながら、改善されたという実施例を示す。 The motivation enhanced by administration of antidepressants, while receiving the medication diet surface so suicidal tendency in some cases to enhance illustrates an embodiment that has been improved. 【実施例1】悩みを抱えるA氏はある宗教の信仰者である。 [Example 1] is a believer of some A, who faced the trouble religion. ある日の寄り合いでかなりのショックを受け、家族にはも打ち明ける勇気がなく、胸に収まっている。 Received a considerable shock and gets close of one day, there is no courage to confide even in the family, it falls within the chest. その後、食欲が減退し、意味不明な言葉を口挟むようになり、どうしたか? After that, the appetite is diminished, made so as to sandwich mouth meaningless words, if you have? と家族が聞いても要領を得ず、本人は人と逢うのはもういやで、精神的ダメージを受けたと家族の皆がそう思ってしかなかった。 The family is not to the point to hear, himself anymore not want to meet the people, all of the family that it has received the psychological damage was not only think so. 家族が心配で大手病院へ連れて行き、臨床検査値の異常がないと云われた。 Family took him to a major hospital in worry, it was said to there is no abnormality of clinical laboratory values.
これでは解決に至らない、同病院の精神神経科に診察して貰えた。 This does not lead to the resolution, was I get to medical examination to the Department of Psychiatry of the hospital. 医師のコンサルテーションでようやく、本人の精神状態が異常であることがわかり、「心身症」と診察され、家族に知らせたところ、家族はちっとも知らなかったと医師に話した。 Finally at the physician's consultation, it can be seen that the mental state of the person is abnormal, diagnosed with "psychosomatic", was made known to the family, the family was told the doctor and did not know not at all. この医師はさらにかなり早期の症状なので、問診してから処置方法を考え、治療方針を打ち出す一方、患者に刺激な言葉を慎むよう家族が注意された。 Because this doctor is a further symptoms quite early, thinking the treatment methods from the interview, while hammer out a course of treatment, the family to refrain from stimulation to the patient word was noted. 本発明の食品を1ケ月食べ続けた結果、病院からの薬も併用しながら、改善が見られた。 A result of food continued to eat one month of the present invention, while the combination also medicine from the hospital, improvement was observed. 本発明の抗うつ病用食品は、上記ホップ、コリアンダー、セリの根、 Anti-depression for the food of the present invention, the hop, coriander, parsley roots,
胡椒、クローブ(丁字)、ミント(薄荷)、菊花およびきのこ類からなる群より選ばれたすくなくとも一つの香辛料またはハーブの食品素材の粉末もしくはエキスを含むものである。 Pepper, cloves (clove), is intended to include mint (mint), at least one of spices or herbs food material powder or extract selected from the group consisting of chrysanthemum and mushrooms. 【0008】まず、本発明に用いるホップ、香辛料またはハーブは熱帯から温帯地方に産出植物の乾燥された花、蕾、葉茎、木皮、種子、果実、根などから得られる香辛料や、薬効または料理、ビールに特徴的な風味付けをするハーブ(分類上香辛料と呼ばれるものも含まれるが、植物の全草、葉、花、果実、根茎等)が用いられる。 [0008] First, hop to be used in the present invention, spices or herbs were dried of production plants from tropical to temperate regions flower, bud, leaf and stem, bark, seeds, fruits, and spices obtained from such as roots, medicinal or food , (but also includes what is called a classification on the spices, all grass plants, leaves, flowers, fruits, rhizomes, etc.) herbs to the characteristic flavor with the beer is used. たとえば、リコリス(甘草)、ホップ(蛇麻草(中国名、学名:Humulus lupuius)、ローズ、ローズマリー、菊花、カモミール、等が挙げられる。 【0009】つぎに、本発明に用いるユリ科の球根は乾燥品であって、品種は特に限されるものではない。 【0010】また、本発明に用いるセリの根は栽培される農作物であって、地上茎を取った残りで、生鮮品であって、とくに品種は限定されるものではない。 【0011】また、本発明に用いられるホップは、桑科に属する蔓植物のまつかさ状緑色花であって、粉末ホップでも適当な溶媒で抽出したものでもよい。 【0012】つぎに、本発明に用いられるきのこ類は、 For example, licorice (licorice), hop (Hebiasakusa (Chinese name, scientific name:. Humulus lupuius), rose, rosemary, chrysanthemum, chamomile, etc. The [0009] Next, the bulbs of the lily family to be used in the present invention is a dry product, varieties are not particularly limited. [0010] root of parsley used in the present invention is a crop cultivated at rest took ground stems, a fresh product, in particular breed it is not intended to be limiting. [0011] hops used in the present invention is a pine cone-shaped green flower vine belonging to Moraceae, be those also extracted with a suitable solvent in powder hop good. [0012] Next, mushrooms used in the present invention,
乾燥品であるシイタケ、生鮮品のシメジ等をあげられる。 Is a dried product shiitake mushrooms, like a mushroom, such as fresh produce. 【0013】 [0013] 子等が挙げられ、例えば、梅は、生果、もしくは梅干、 Child, and the like, for example, plum, Namahate or plum,
梅漬、梅果汁などの加工品の形態で用いられる。 Umezuke used in processed products in the form of plum juice. 【0014】以上のような食品素材の形態は、食品素材の乾燥物の粉末でもよく、これらを粉砕して水蒸気蒸留等を行って得られる精油でもよく、もしくは上記食品素材を水やエタノール等の溶媒で抽出したエキスでもよい。 [0014] The above-described food material form, a dried product of the food material powder may be, it was triturated well in essential oil obtained by performing steam distillation or the like, or the food material water, ethanol, etc. it may be extract extracted with a solvent. またホップ一種でも、または数種組み合わせて用いてもよい。 Or it may be used in combination also or several hop type. 特にこれらと共に、クエン酸等の植物有機酸、或いは植物有機酸を多く含むグレープ、オレンジ、 Especially with these plants organic acids such as citric acid, or grape-rich plant organic acids, Orange,
イチゴ、桃等の果汁等を併用すると、うつ病に対する相乗効果が認められ好適である。 Strawberries, when combined fruit juice peach etc., it is preferable observed synergistic effect on depression. 【0015】なお、これらの食品素材中には例えば、表1に示すような成分が含まれている。 [0015] Note that in these food materials for example, are included components shown in Table 1. また、これらは抗うつ病作用の有無を表2に示す。 It also shows the presence or absence of anti-depression effect in Table 2. 【0016】 【表1】 [0016] [Table 1] 【0017】 【表2】 [0017] [Table 2] 【0018】 【表3】抗うつ病用組成物の組成ホップエキス 2ml 丁字エキス 0.01ml セリの根 1g 枸杞子 10g 植物有機酸 適量植物多糖 適量酸棗仁エキス 2ml 蓮子 10g 【0019】次にこれらの食品素材を添加する食品としては、ガム、キャンデー、ゼリー、錠菓、飲料等が挙げられる。 [0018] [Table 3] Composition Hop extract 2ml clove root 1g Kukoko 10g vegetable organic acid qs plant polysaccharides suitable amount San'natsume Hitoshi extract 2ml Renko 10g [0019] Extract 0.01ml Seri antidepressant composition Next thereof the food is added to food materials, gum, candy, jelly, tablet candy, drinks and the like. 特にガム、キャンディ、錠菓は、何時でもどこでも食べたいときに、食べられるので好適である。 In particular, gum, candy, tablet candy, when you want to eat at any time anywhere, is preferred because it is eaten. 【0020】また、添加する方法も特に限定するものではなく、常法に従い、他の原料と共に混合し、調整すればよい。 Further, the method of adding not limited particularly also in a conventional manner, and mixed with other raw materials may be adjusted. 更に、上記食品用素材は、熱に対しても安定であるため、加温飲料、スナック菓子、ケーキ等高温で加熱される食品に対しても用いることができる。 Further, the food materials are the stable against heat, it can also be used for heating beverages, snacks, food to be heated in the cake or the like hot. 【0021】 【発明の効果】以上のように、本発明の抗うつ病用食品は、うつ病に対し優れた抗うつ病作用を有するものである。 [0021] As described above, according to the present invention, antidepressant food of the present invention has an excellent anti-depressive effect on depression. しかも食品素材を原料としている点があるので、食品の風味を損なわないこと且つ安性が高い。 In addition, since there is a point that the food material as a raw material, is high and cheap property that does not impair the flavor of food. また、熱に対して安定なので多様な形態の食品とすることができる。 Further, since the stability can be food various forms to heat.

Claims (1)

  1. 【特許請求の範囲】 下記の群から選ばれたすくなくとも一つの食品素材の粉末またはエキスを含有し、うつに対する抗うつ病作用を有することを特徴とする抗うつ病用食品。 It contains Claims least one food material of powder or extract selected from the following group, the anti-depressive for food which have an anti-depressive effect on depression. a)ホップ、コリアンダー、セリの根、胡椒、クローブ(丁字)、ミント(薄荷)、菊花およびきのこ類からなる群より選ばれるすくなくとも一つの香辛料またはハーブ。 a) hops, coriander, parsley roots, pepper, cloves (clove), mint (peppermint), at least one of spices or herbs selected from the group consisting of chrysanthemum and mushrooms. b)バラ科の果実c)ユリ科の球根d)昆布詳細な説明 b) bulbs d of fruit c) lily family Rosaceae) kelp detailed description
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Cited By (7)

* Cited by examiner, † Cited by third party
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WO2007134868A3 (en) * 2006-05-24 2008-06-12 Saizieu Antoine De 3,5-dihydroxy-2,4-cyclohexadienones and their derivatives, dietary compositions and fortified food containing them and their uses
DE102005014334B4 (en) * 2005-03-24 2009-06-10 Franz Udo Willerscheidt Sedative comprehensively myrrh, licorice root and wine
WO2010021247A1 (en) 2008-08-21 2010-02-25 サントリーホールディングス株式会社 Pharmaceutical preparation, food or beverage having inhibitory activity on serotonin transporter
JP2011105627A (en) * 2009-11-16 2011-06-02 Prefectural Univ Of Hiroshima Anti-stress composition containing extracted fraction of lily bulb
JP2012158536A (en) * 2011-01-31 2012-08-23 Noda Shokukin Kogyo Kk Antidepressant
WO2013118906A1 (en) * 2012-02-06 2013-08-15 サントリーホールディングス株式会社 Monoterpene glycosyltransferase originating from hop and method for using same
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