JP2002038133A - Antistatic agent - Google Patents
Antistatic agentInfo
- Publication number
- JP2002038133A JP2002038133A JP2000225146A JP2000225146A JP2002038133A JP 2002038133 A JP2002038133 A JP 2002038133A JP 2000225146 A JP2000225146 A JP 2000225146A JP 2000225146 A JP2000225146 A JP 2000225146A JP 2002038133 A JP2002038133 A JP 2002038133A
- Authority
- JP
- Japan
- Prior art keywords
- antistatic agent
- antistatic
- molded article
- molded
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、帯電防止剤やそれ
を用いた帯電防止能を有する成型体、詳しくは、酵素処
理した酵母から可溶性菌体成分を除去した菌体残さを酸
性水溶液で処理し、さらに可溶化物を除去した残さから
なる酸処理酵母細胞壁画分を主成分とする帯電防止剤や
それを用いた帯電防止機能を備えた成型体に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antistatic agent and a molded article having an antistatic function using the same, and more particularly, to a method of treating a cell residue obtained by removing soluble cell components from an enzyme-treated yeast with an acidic aqueous solution. Further, the present invention relates to an antistatic agent mainly composed of an acid-treated yeast cell wall fraction comprising a residue obtained by removing a solubilized substance, and a molded article having an antistatic function using the same.
【０００２】[0002]
【従来の技術】静電気の発生現象については、これまで
いろいろ研究されているが、現象が複雑であるために、
現在でも理論的究明が完全になされておらず、一般的に
は静電気の発生現象は異種又は同種の物質を摩擦した
り、分離した場合、物体間で電子又はイオンの移動が起
こり静電気が発生するといわれている。静電気等により
電荷を帯びた物体から電荷を除去する帯電防止方法は、
外的帯電防止方法と内的帯電防止方法の２つの方法に大
別することができる。対象物が導体である場合にはアー
スを行い電荷を放出させることで簡単に除電することが
できるが、対象物が絶縁体である場合の外的帯電防止方
法としては、除電ブラシ・リボンなどでコロナ放電を発
生させ電荷を除去したり、除電器により帯電物質と逆の
電荷のイオンを電極より発生させ帯電を中和させること
により電荷を除去する方法が知られている。また、外気
の湿度・室温を上昇させることで帯電を環境的に防止す
る方法も知られている。2. Description of the Related Art Various studies have been made on the generation of static electricity, but the phenomenon is complicated.
Even now, theoretical investigations have not been completely completed, and in general, the phenomenon of static electricity generation is when electrons or ions move between objects due to friction or separation of different or similar materials, and static electricity is generated. It is said. An antistatic method for removing charge from an object charged by static electricity or the like is as follows.
It can be roughly classified into two methods, an external antistatic method and an internal antistatic method. If the object is a conductor, the charge can be easily removed by grounding and releasing the charge.However, when the object is an insulator, an external antistatic method is to use a neutralizing brush or ribbon. There is known a method of generating a corona discharge to remove charges, or removing charges by neutralizing the charges by generating ions having charges opposite to that of a charged substance from an electrode by a static eliminator. There is also known a method of environmentally preventing charging by increasing the humidity and room temperature of the outside air.
【０００３】他方、合成樹脂などの高分子化合物は、ほ
とんど電気的に不良導体であるため帯電をしやすく、製
品の帯電による汚れの吸着、性能低下、印刷や接着不良
を起こし問題となっている。かかる合成樹脂などの絶縁
物質に対しては導電性物質の添加・練り込みや、帯電防
止物質のコーティングなど帯電物質本体を導電化させる
内的帯電防止方法もよく知られている。例えば、低分子
界面活性剤をプラスチック製品や合成繊維などに練り込
んだり、表面に塗布したりすることが行われているが、
拭き取りや洗濯などにより容易に除去されるという問題
があり、そこで、半永久的に効果を持続させるために、
ポリエチレングリコール（ＰＥＧ）、ポリオキシエチレ
ンジアミン、ポリビニルベンジルトリメチルアンモニウ
ムクロライド、ポリジアリルジメチルアンモニウムクロ
ライド、ポリスチレンスルホン酸ソーダ等の合成高分子
型の帯電防止剤が現在多く使われてきている。[0003] On the other hand, polymer compounds such as synthetic resins are almost electrically poor conductors and are therefore liable to be charged, resulting in problems such as adsorption of dirt due to charging of the product, deterioration of performance, and poor printing and adhesion. . For an insulating material such as a synthetic resin, an internal antistatic method for making a charged material main body conductive, such as adding and kneading a conductive material or coating an antistatic material, is also well known. For example, low-molecular surfactants are kneaded into plastic products and synthetic fibers, and are applied to the surface.
There is a problem that it is easily removed by wiping or washing, so in order to maintain the effect semipermanently,
Currently, synthetic polymer type antistatic agents such as polyethylene glycol (PEG), polyoxyethylenediamine, polyvinylbenzyltrimethylammonium chloride, polydiallyldimethylammonium chloride, and sodium polystyrenesulfonate are widely used.
【０００４】このような合成高分子系のものに対し、デ
キストラン、プルラン、カードラン、キサンタンガム、
ゲランガム、ヒアルロン酸等の植物・動物・微生物由来
の種々の多糖類が、天然系の物質であり安全性も高いた
め医薬、食品、化粧品といった分野で利用が拡大されつつ
ある。例えば、微生物由来のものとして、特開平８−３
１９４７５号公報には、アグロバクテリウム属細菌が生
産する構成糖が、Ｄ−グルコース、Ｄ−ガラクトース、
Ｄ−グルクロン酸、Ｄ−リボースおよびＤ−リブロン酸
の５種類からなり、その構成モル比が、Ｄ−グルコー
ス：Ｄ−ガラクトース：Ｄ−グルクロン酸：Ｄ−リボー
ス：Ｄ−リブロン酸＝１０：１．８〜２．９：１．８〜
２．６：０．５〜１．７：０．５〜１．７でＯ−アセチ
ル基含有量が０〜１０重量％である優れた帯電防止能を
持つ多糖類を成分とした多糖類系帯電防止剤が記載され
ている。また、特開平９−１３０１１号公報には、クレ
プシェラ属オキシトカ種の一変異種株菌によって生産さ
れる多糖類であるＤ−グルクロン酸、Ｌ−ラムノース、
Ｄ−ガラクトースおよびＤ−グルコースからなり、その
構成モル比が、Ｄ−グルクロン酸：Ｌ−ラムノース：Ｄ
−ガラクトース：Ｄ−グルコース＝０．８〜１．２：
２．４〜３．６：０．８〜１．２：０．８〜１．２であ
る優れた帯電防止能を持つ多糖類を有効成分とした多糖
類系帯電防止剤が記載されている。[0004] Dextran, pullulan, curdlan, xanthan gum,
BACKGROUND ART Various polysaccharides derived from plants, animals, and microorganisms such as gellan gum and hyaluronic acid are natural substances and have high safety, and thus their use is expanding in the fields of medicine, food, and cosmetics. For example, as those derived from microorganisms,
Japanese Patent No. 19475 discloses that constituent sugars produced by Agrobacterium bacteria are D-glucose, D-galactose,
It is composed of D-glucuronic acid, D-ribose and D-riburonic acid, and the constituent molar ratio is D-glucose: D-galactose: D-glucuronic acid: D-ribose: D-riburonic acid = 10: 1. 0.8 to 2.9: 1.8 to
2.6: 0.5 to 1.7: 0.5 to 1.7 and a polysaccharide based on a polysaccharide having an O-acetyl group content of 0 to 10% by weight and having an excellent antistatic ability. Antistatic agents are described. Japanese Patent Application Laid-Open No. 9-13011 discloses that D-glucuronic acid, L-rhamnose, which are polysaccharides produced by a mutant strain of the species Oxytoca of the genus Klebsiella,
It is composed of D-galactose and D-glucose, and its constituent molar ratio is D-glucuronic acid: L-rhamnose: D
-Galactose: D-glucose = 0.8 to 1.2:
A polysaccharide-based antistatic agent containing a polysaccharide having an excellent antistatic ability of 2.4 to 3.6: 0.8 to 1.2: 0.8 to 1.2 as an active ingredient is described. .
【０００５】一方、酵母からフィルム素材を開発しよう
とする試みもなされており、例えば、特公昭５６−１９
９７１号公報には、脱核酸酵母から酵母細胞膜成分を除
去して、水に可溶性のタンパク質を主成分とする可食性
タンパク質フィルムが開示され、特開昭５３−４５３８
５号公報には、酵母などの微生物菌体を熱アルカリ処理
後、酸を加えて等電点沈殿処理を施し、生成した沈殿物
のｐＨを６〜８に調節して得られるゲル形成性微生物菌
体に可塑剤を配合してなる組成物を製膜するフィルムの
製造方法が開示されている。また、酵母エキスを抽出す
る際に残さとして残った細胞壁を主体とする物質を脱色
・脱臭方法も知られており、例えば、特開平４−２４８
９６８号公報には、抽出残さをアルカリ及び酸で処理し
た後、１０００〜２０００ｐｐｍのオゾンで処理すると
ともに、該オゾン処理の前後にエタノールで処理する酵
母エキス抽出残さの脱色・脱臭方法が開示され、また特
開平９−１０３２６６号公報には、酵母自己消化不溶物
をエタノールで懸濁させてアルカリ下で攪拌処理する酵
母自己消化不溶物の無味無臭化方法が開示されている。On the other hand, attempts have been made to develop a film material from yeast, for example, Japanese Patent Publication No. 56-19 / 1981.
No. 971 discloses an edible protein film containing a water-soluble protein as a main component by removing yeast cell membrane components from a denucleated yeast.
No. 5 discloses a gel-forming microorganism obtained by subjecting a microbial cell such as a yeast to a hot-alkali treatment, adding an acid thereto, and performing isoelectric point precipitation treatment, and adjusting the pH of the resulting precipitate to 6 to 8. A method for producing a film for forming a composition in which a plasticizer is blended with bacterial cells is disclosed. In addition, a method of decolorizing and deodorizing a substance mainly composed of cell walls remaining as a residue when extracting yeast extract is also known.
No. 968 discloses a method for decolorizing and deodorizing a yeast extract extraction residue, in which the extraction residue is treated with an alkali and an acid, then treated with 1000 to 2000 ppm of ozone, and treated with ethanol before and after the ozone treatment. Japanese Patent Application Laid-Open No. 9-103266 discloses a method for deodorizing yeast self-digesting insolubles by suspending the yeast autolyzing insolubles in ethanol and stirring the mixture under alkali.
【０００６】[0006]
【発明が解決しようとする課題】帯電防止方法は概ね確
立されているということができるが、除電器などは除電
スピードが遅かったり、除電ブラシの接触による除電で
は帯電を除去したい物質自体を傷つけてしまうことが問
題となる。また、絶縁物質の導電化についても帯電防止
剤（ＰＥＧオレイン酸エステル等）のような合成高分子
系のものを添加する場合、直接皮膚に接触するものや、
経口的に摂取するものに対してはその使用範囲が制限さ
れるという問題がある。また、植物・動物・微生物由来
の多糖類系のものについてはゲルろ過等の精製操作が必
要であり、特に微生物由来の多糖類の場合、製造時に微
生物の培養を行う必要があり、工程が煩雑になるという
問題がある。It can be said that an antistatic method is generally established, but a static eliminator or the like has a slow static elimination speed, or the static elimination by contact with a static elimination brush damages the substance itself to be eliminated. Is a problem. In addition, regarding the conductivity of the insulating material, when a synthetic polymer-based material such as an antistatic agent (such as PEG oleate) is added, a material that directly contacts the skin,
There is a problem that the range of use is restricted for those who take it orally. In addition, for polysaccharides derived from plants, animals, and microorganisms, purification operations such as gel filtration are required. Particularly, in the case of polysaccharides derived from microorganisms, microorganisms need to be cultured during production, and the process is complicated. Problem.
【０００７】また、粉体などの帯電に影響を受けやすい
物質を充填する包材の一つとしてカプセルが挙げられる
が、カプセルはほとんどの場合、帯電が発生し易いゼラ
チンで出来ており、このため、カプセル自体が有する帯
電し易いという性質により多くの問題が生じる。かかる
問題としては、例えば、カプセル自体の帯電により生じ
るブロッキングによるカプセルの搬送不良、１カプセル
づつに分ける仕分けの不良等のカプセル中への粉体等の
充填の前工程での問題や、カプセル外面に発生した静電
気により内部の粉体・顆粒等内包薬剤がカプセル外面に
付着することで、カプセルによる苦味・臭気等の防止効
果が喪失したり、外面に付着した内包薬剤の吸湿や変質
によるカプセルのブロッキング・変性・変色・破損・強度劣
化等が発生するという問題や、静電気により飛散した粉
体等により光学的なカプセル充填の検査機のレンズを汚
すことで検査不良を引き起こし易くなるという問題など
が挙げられる。[0007] Capsules are one of the packing materials for filling a substance which is susceptible to electrification such as powder. However, in most cases, the capsules are made of gelatin which is liable to be electrified. Many problems arise due to the easily charged nature of the capsule itself. Such problems include, for example, problems in the pre-process of filling the capsules with powder and the like, such as poor transport of the capsule due to blocking caused by charging of the capsule itself, poor sorting of the capsules, and the like. Due to the generated static electricity, the internal medicines such as powders and granules adhere to the outer surface of the capsule, so that the effect of the capsule on preventing bitterness and odor from being lost is lost, and the encapsulated medicines adhering to the outer surface are blocked by moisture absorption and deterioration of the capsule -Problems such as denaturation, discoloration, breakage, deterioration of strength, etc. occur, and problems that inspection defects tend to be caused by soiling the lens of the optical capsule filling inspection machine with powder scattered by static electricity etc. Can be
【０００８】粉体・顆粒などのコーティングに、エチル
セルロース等の高分子系コーティング剤を使用し、流動
層造粒でコーティングが行われている。かかるコーティ
ング工程において、粉体の帯電による造粒機壁面への付
着により、不均一なコーティング物が作られたり、顆粒
同士が帯電により結着し不均一な粒子径の顆粒ができた
りする問題がある。また、帯電性の強いコーティング剤
を使用した場合、回収時に壁面に衝撃を加えて付着分を
落とさなければならない等の作業性の悪化や回収できな
い部分による収率低下などの問題がある。[0008] The coating of powders and granules is performed by fluidized bed granulation using a polymer coating agent such as ethyl cellulose. In such a coating process, there is a problem that a non-uniform coating is produced due to adhesion of powder to a granulator wall surface due to electrification, or granules having an irregular particle diameter are formed by binding of granules by electrification. is there. In addition, when a coating agent having a strong chargeability is used, there are problems such as deterioration in workability such as a need to apply an impact to a wall surface during collection to reduce the amount of adhesion, and a decrease in yield due to an unrecoverable portion.
【０００９】本発明の課題は、上記の問題を解決しう
る、安全でその適用範囲が制限されることがなく、かつ
煩雑な工程を要することなく製造することができる帯電
防止剤を用いて、優れた帯電防止機能の他、紫外線遮光
機能、防湿機能、ガスバリア機能等に優れた性状・物性
を有する成型体を提供することにある。It is an object of the present invention to provide an antistatic agent which can solve the above-mentioned problems, is safe, its application range is not limited, and can be produced without complicated steps. An object of the present invention is to provide a molded article having excellent properties and physical properties such as an ultraviolet light shielding function, a moisture proof function, a gas barrier function and the like in addition to an excellent antistatic function.
【００１０】[0010]
【課題を解決するための手段】本発明者らは、酵母細胞
壁画分についての研究過程で、従来の脱臭・脱色の目的
で行われていたアルカリ処理・酸処理の併用による酵母
の処理条件とは異なり、酵母細胞壁画分を単に酸性水溶
液を用いて処理し、さらに可溶化物を除去した残さから
なる酸処理酵母細胞壁画分から成型した成型体が優れた
帯電防止作用を有することを見い出し、本発明を完成す
るに至った。Means for Solving the Problems In the course of research on the yeast cell wall fraction, the present inventors have investigated the conditions of yeast treatment by a combination of alkali treatment and acid treatment, which had been conventionally performed for the purpose of deodorization and decolorization. Differently, the yeast cell wall fraction was simply treated with an acidic aqueous solution, and the molded body molded from the acid-treated yeast cell wall fraction consisting of the residue obtained by removing the solubilized material was found to have excellent antistatic properties. The invention has been completed.
【００１１】すなわち本発明は、酵素処理した酵母から
可溶性菌体内成分を除去した菌体残さを酸性水溶液で処
理し、さらに可溶化物を除去した残さからなる酸処理酵
母細胞壁画分を主成分とすることを特徴とする帯電防止
剤（請求項１）や、帯電防止剤が、さらに可塑剤を含む
ものであることを特徴とする請求項１記載の帯電防止剤
（請求項２）や、請求項１又は２記載の帯電防止剤を用
いて成型したことを特徴とする帯電防止能を有する成型
体（請求項３）や、基体に帯電防止剤を単層又は複層に
コーティングすることにより得られることを特徴とする
請求項３記載の帯電防止能を有する成型体（請求項４）
や、シート形状又はフィルム形状に成型されたことを特
徴とする請求項３又は４記載の帯電防止能を有する成型
体（請求項５）や、顆粒形状に成型されたことを特徴と
する請求項４記載の帯電防止能を有する成型体（請求項
６）や、カプセル形状に成型されたことを特徴とする請
求項３記載の帯電防止能を有する成型体（請求項７）
や、２３℃、ＲＨ５０％における表面固有抵抗が、１０
6〜１０9Ωであることを特徴とする請求項３〜７のいず
れか記載の帯電防止能を有する成型体（請求項８）に関
する。That is, the present invention comprises, as a main component, an acid-treated yeast cell wall fraction obtained by treating a cell residue obtained by removing soluble intracellular components from an enzyme-treated yeast with an acidic aqueous solution and further removing a solubilized substance. 2. The antistatic agent according to claim 1, wherein the antistatic agent further comprises a plasticizer. 2. The antistatic agent according to claim 1, wherein the antistatic agent further comprises a plasticizer. Or a molded article having an antistatic ability characterized by being molded by using the antistatic agent according to (2), or obtained by coating a single or multiple layers of an antistatic agent on a substrate. The molded article having an antistatic ability according to claim 3, characterized in that:
5. A molded article having an antistatic ability according to claim 3 or 4, wherein the molded article is molded into a sheet shape or a film shape, or a granulated shape. The molded article having antistatic ability according to claim 4 (claim 6) or the molded article having antistatic ability according to claim 3 molded into a capsule shape (claim 7).
And the surface resistivity at 23 ° C. and 50% RH is 10
The molded article having an antistatic ability according to any one of claims 3 to 7, wherein the molded article has an antistatic property of 6 to 10 9 Ω.
【００１２】[0012]
【発明の実施の形態】本発明の帯電防止剤としては、酵
素処理した酵母から可溶性菌体内成分を除去した菌体残
さを酸性水溶液で処理し、さらに可溶化物を除去した残
さからなる酸処理酵母細胞壁画分を主成分とするもので
あればどのようなものでもよく、また、本発明の帯電防
止能を有する成型体としては、酵素処理した酵母から可
溶性菌体内成分を除去した菌体残さを酸性水溶液で処理
し、さらに可溶化物を除去した残さからなる酸処理酵母
細胞壁画分を主成分とする帯電防止剤を用いて成型した
成型体であれば特に制限されるものではない。BEST MODE FOR CARRYING OUT THE INVENTION As an antistatic agent of the present invention, an acid treatment consisting of a cell residue obtained by removing soluble intracellular components from an enzyme-treated yeast is treated with an acidic aqueous solution, and further a solubilized substance is removed. Any type may be used as long as it has a yeast cell wall fraction as a main component, and the molded article having an antistatic ability of the present invention is a cell residue obtained by removing soluble intracellular components from yeast treated with an enzyme. Is not particularly limited as long as it is molded using an antistatic agent mainly composed of an acid-treated yeast cell wall fraction consisting of a residue obtained by treating a solubilized substance with an acidic aqueous solution.
【００１３】（原料酵母）本発明の帯電防止剤の原料と
なる酵母としては、分類学上酵母に属するものであれば
どのような酵母を用いてもよく、例えば、ビール酵母、
ワイン酵母、パン酵母、トルラ酵母等を挙げることがで
き、より具体的には、サッカロマイセス属のサッカロマ
イセス・セレビッシェ（Saccharomyces cerevisiae）、
サッカロマイセス・ルーキシ（Saccharomyces rouxi
i）、サッカロマイセス・カールスバーゲンシス（Sacch
aromyces carlsbergensis）、キャンディダ・ウティリ
ス（Candida utilis）、キャンディダ・トロピカリス
（Candida tropicalis）、キャンディダ・リポリティカ
（Candida lipolytica）、キャンディダ・フレーベリ
（Candida flaveri）等を例示することができる。そし
て、これら酵母は、単独あるいは組み合わせて使用する
ことができる。また、酵母としては生酵母を用いること
が好ましいが、乾燥酵母等の生酵母以外の形態の酵母を
用いる場合であっても、例えば水中等に懸濁して生酵母
同様に処理することもできる。さらに、使用する酵母の
形状や大きさに特に制限はないが、形状としてはなるべ
く球形に近い形状のものが好ましく、また、その大きさ
は１〜２０μｍの範囲のものが好ましい。(Raw material yeast) As the yeast to be used as a raw material of the antistatic agent of the present invention, any yeast may be used as long as it belongs to taxonomical yeasts.
Examples thereof include wine yeast, baker's yeast, and tolula yeast, and more specifically, Saccharomyces cerevisiae of the genus Saccharomyces,
Saccharomyces rouxi
i), Saccharomyces Carlsbergensis (Sacch
aromyces carlsbergensis), Candida utilis, Candida tropicalis, Candida lipolytica, Candida flaveri, and the like. These yeasts can be used alone or in combination. It is preferable to use live yeast as the yeast. However, even when yeast other than live yeast such as dried yeast is used, the yeast can be suspended in water or the like and treated in the same manner as live yeast. Further, the shape and size of the yeast used are not particularly limited, but the shape is preferably as close to spherical as possible, and the size is preferably in the range of 1 to 20 μm.
【００１４】（酸処理酵母細胞壁画分）酵母には、水も
しくは極性溶剤に可溶性の菌体内成分、例えばたんぱく
質、アミノ酸、糖質、核酸、有機酸などの成分が存在し
ており、酵母からこれら可溶性菌体内成分を除去して酵
母細胞壁画分を得るためには、酵素処理によりこれらの
菌体内成分を可溶化して菌体外に除去することが必要で
ある。そして、酵素処理としては、酵母菌体内の酵素を
使用するいわゆる自己消化法や、外部からプロテアー
ゼ、ヌクレアーゼ、β−グルカナーゼ、エステラーゼ、
リパーゼ等の酵素を添加する酵素添加方法や、それらを
併用する方法等、いずれも酵母菌体内成分を食用に可溶
化する際に用いられている方法であれば、どのような酵
素処理法をも用いることができる。また、酵素処理を速
やかに行うなどの目的で、酵母の酵素処理の前に、高圧
ホモジナイザーなどにより細胞壁の物理的な破壊を伴う
前処理を行ってもよく、この高圧ホモジナイザーを用い
る場合は、例えば１００〜１０００ｋｇ／ｃｍ2の圧力
下で処理することが好ましい。酵素処理を終えた酵母
は、例えば遠心分離等の可溶性菌体内成分の除去処理を
施すことによって、その菌体残さとして酵母細胞壁画分
が得られる。このように、化学的処理を特に施すことな
く得られる酵母細胞壁画分は、グルカン、マンナン、キ
チン層からなる物理的、化学的に比較的丈夫な皮膜を含
んでいる。その他必要に応じて、酵母の洗浄処理、ｐＨ
・温度・圧力の調整処理等を組み入れて、酵母細胞壁画
分を調製することもできる。(Acid-treated yeast cell wall fraction) Yeast contains intracellular components soluble in water or a polar solvent, for example, components such as proteins, amino acids, carbohydrates, nucleic acids, and organic acids. In order to remove the soluble intracellular components and obtain a yeast cell wall fraction, it is necessary to solubilize these intracellular components by enzymatic treatment and remove them outside the cells. As the enzyme treatment, a so-called self-digestion method using an enzyme in a yeast cell, or a protease, nuclease, β-glucanase, esterase,
Any enzyme treatment method, such as an enzyme addition method of adding an enzyme such as lipase or a method of using them in combination, can be used as long as it is a method used for solubilizing edible components of yeast cells. Can be used. Further, for the purpose of performing the enzyme treatment promptly, before the enzyme treatment of yeast, a pretreatment involving physical destruction of the cell wall may be performed by a high-pressure homogenizer or the like.When using the high-pressure homogenizer, for example, The treatment is preferably performed under a pressure of 100 to 1000 kg / cm 2 . The yeast which has been subjected to the enzyme treatment is subjected to a treatment for removing soluble intracellular components such as centrifugation, whereby a yeast cell wall fraction is obtained as a residue of the yeast. As described above, the yeast cell wall fraction obtained without any particular chemical treatment contains a relatively physically and chemically robust film composed of a glucan, mannan, and chitin layer. In addition, if necessary, washing treatment of yeast, pH
-A yeast cell wall fraction can also be prepared by incorporating temperature / pressure adjustment and the like.
【００１５】酸処理酵母細胞壁画分は、酵母の酵素処理
により可溶性菌体内成分を除去することによって得られ
た上記酵母細胞壁画分を酸性水溶液で処理し、さらに可
溶化分を除去した酵母菌体残さとしてを調製することが
でき、より具体的には上記酵母細胞壁画分を０．０１〜
２Ｎ、好ましくは０．１〜０．５Ｎの例えば塩酸、硫
酸、硝酸等の酸で処理した後、その懸濁液を遠心分離等
により上清と酵母菌体残さに分離し、この酵母菌体残さ
を採取することにより調製することができる。また、酸
処理に際しては８０℃前後に加熱することが好ましい。
かかる酸処理酵母細胞壁画分は天然素材であり、素材的
に安全性も高い。また、この酸処理酵母細胞壁画分は、
ラットへの経口投与で腸内細菌で分解することが確認さ
れているように、生分解性を有することから廃棄上も問
題がない。かかる酸処理酵母細胞壁画分の構成成分を以
下の表１に示す。なお、表１中の「食物繊維」にはβグ
ルカン以外にキチン等も含まれ、また、タンパク質係数
としては６．２５が用いられている。The acid-treated yeast cell wall fraction is obtained by removing the soluble intracellular components by enzymatic treatment of yeast, treating the yeast cell wall fraction with an acidic aqueous solution, and removing the solubilized components. Residue can be prepared, more specifically, the yeast cell wall fraction is 0.01 to
After treatment with 2N, preferably 0.1 to 0.5N acid such as hydrochloric acid, sulfuric acid, nitric acid or the like, the suspension is separated into a supernatant and a yeast cell residue by centrifugation or the like. It can be prepared by collecting the residue. In the acid treatment, it is preferable to heat to about 80 ° C.
Such an acid-treated yeast cell wall fraction is a natural material and is highly safe as a material. In addition, this acid-treated yeast cell wall fraction
As it has been confirmed that it is degraded by intestinal bacteria upon oral administration to rats, there is no problem in disposal because it is biodegradable. The components of such an acid-treated yeast cell wall fraction are shown in Table 1 below. Note that "dietary fiber" in Table 1 includes chitin and the like in addition to β-glucan, and 6.25 is used as a protein coefficient.
【００１６】[0016]
【表１】 [Table 1]
【００１７】（帯電防止剤）本発明の酸処理酵母細胞壁
画分を主成分とする帯電防止剤には、酸処理酵母細胞壁
画分からなる帯電防止剤の他に、酸処理酵母細胞壁画分
に必要に応じて添加剤が配合された帯電防止剤も含まれ
る。酸処理酵母細胞壁画分をそのまま用いても優れた帯
電防止剤となるが、コーティングする場合の伸展性やそ
れから成型した成型体の耐水性などの向上を目的とし
て、可塑剤等の添加剤を用いることもできる。これら添
加剤としては、食品分野における場合、グリセリン、ソ
ルビトール、アミノ酸類、有機酸類、モノグリセリド、
ジグリセリド、トリグリセリド、ＭＣＴを中心とした油
脂類、ゼラチン、寒天・キトサン等の多糖類、砂糖等の
糖類などを可塑剤として具体的に例示することができ、
また、医薬品分野における場合、トリアセチン、クエン
酸トリエチル、アセチル化モノグリセリドなどの医薬品
添加剤リスト収載の全ての可塑剤、保湿剤、結合剤など
を挙げることができる。また、本発明の帯電防止剤の形
態としては、スラリー状、乾燥粉体状等を挙げることが
でき、乾燥粉体状のものは水等の水性媒体で分散させて
使用されるが、スラリー状のものは塑性流動体であり、
乾燥工程を必要としない点で有利に用いることができ
る。本発明の帯電防止剤は、また、従来の多糖類系帯電
防止剤と比べて、粘性の割に仕上がりにべとつきがない
という特徴を有している。(Antistatic Agent) The antistatic agent containing the acid-treated yeast cell wall fraction of the present invention as a main component is required for the acid-treated yeast cell wall fraction in addition to the antistatic agent composed of the acid-treated yeast cell wall fraction. And an antistatic agent in which an additive is blended according to the above. Even if the acid-treated yeast cell wall fraction is used as it is, it will be an excellent antistatic agent, but using additives such as a plasticizer for the purpose of improving the extensibility when coating and the water resistance of the molded product molded therefrom. You can also. In the food field, these additives include glycerin, sorbitol, amino acids, organic acids, monoglycerides,
Diglycerides, triglycerides, fats and oils centering on MCT, gelatin, polysaccharides such as agar / chitosan, and sugars such as sugar can be specifically exemplified as plasticizers.
In the case of the pharmaceutical field, all plasticizers, humectants, binders and the like listed on the pharmaceutical additive list such as triacetin, triethyl citrate, and acetylated monoglyceride can be mentioned. Examples of the form of the antistatic agent of the present invention include a slurry form and a dry powder form. The dry powder form is used by being dispersed in an aqueous medium such as water. Are plastic fluids,
It can be advantageously used in that a drying step is not required. The antistatic agent of the present invention also has a feature that, compared to a conventional polysaccharide-based antistatic agent, the finish is less sticky for its viscosity.
【００１８】（帯電防止能を有する成型体の成型）本発
明の帯電防止能を有する成型体は、上記本発明の帯電防
止剤を用いて成型することにより得ることができる。か
かる成型方法としては特に制限されるものでなく、例え
ば、帯電防止能を付与したい基体の片面若しくは両面又
は一部若しくは全体に、スラリー状の本発明の帯電防止
剤を単層又は複層にコーティングし、乾燥することによ
り、帯電防止能を有する被膜と基体からなる本発明の成
型体が得られ、かかる成型体の基体から被膜を剥離する
ことによりシート形状やフィルム形状の本発明の成型体
を得ることができる。そして、かかるフィルム形状等の
成型体は単独又は基体に貼着して用いることができる。
上記基体の形状としては板状、粒状物状等特に制限され
るものではなく、また基体の材質も特に制限されない
が、例えばプラスティック等の高分子素材、硝子、天然
繊維、布、紙類、粒状薬剤等を例示することができる。
また、スラリー状の本発明の帯電防止剤に所望の形状の
型をディッピングした後乾燥することにより、カプセル
形状等の種々の形状の成型体を成型することができる。(Molding of molded article having antistatic ability) The molded article having antistatic ability of the present invention can be obtained by molding using the antistatic agent of the present invention. The molding method is not particularly limited. For example, a single layer or multiple layers of the antistatic agent of the present invention in a slurry form may be coated on one or both sides or a part or the whole of a substrate to be provided with antistatic ability. Then, by drying, a molded article of the present invention comprising a coating having an antistatic ability and a substrate is obtained. By peeling the coating from the substrate of the molded article, the molded article of the present invention in a sheet or film shape is obtained. Obtainable. Then, such a molded article having a film shape or the like can be used alone or attached to a substrate.
The shape of the substrate is not particularly limited, such as a plate, a granular material, etc., and the material of the substrate is not particularly limited. For example, polymer materials such as plastic, glass, natural fibers, cloth, papers, and granular materials Drugs and the like can be exemplified.
In addition, by dipping a mold having a desired shape into the slurry of the antistatic agent of the present invention and then drying it, molded articles having various shapes such as a capsule shape can be formed.
【００１９】（帯電防止能を有する成型体の性状・物
性）本発明の成型体は帯電防止機能の他、紫外線遮光機
能、防湿機能、ガスバリア機能等優れた性状を有してい
る。成型体の帯電防止能としては、ＡＳＴＭ Ｄ２５７
による測定法に基き測定した場合の表面固有抵抗が、２
３℃、ＲＨ５０％において、１０9Ω以下、例えば１０6
〜１０9Ωの低抵抗値が好ましい。またフィルム状成型
体のガスバリア性について、酸素、水素・二酸化炭素・
窒素についてのガス透過係数を酸素はＪＩＳＫ７１２６
Ｂ法（モコン法）、炭酸ガスはモコン法、水素・窒素
はＪＩＳＫ７１２６ Ａ法に基づき測定したところ、酸
素透過係数は０．００３ｃｍ3・ｍｍ／ｍ2・２４ｈ・ａ
ｔｍ、水素透過係数は０．７７ｃｍ3・ｍｍ／ｍ2・２４
ｈ・ａｔｍ、二酸化炭素透過係数は０．１５ｃｍ3・ｍ
ｍ／ｍ2・２４ｈ・ａｔｍ、窒素透過係数は０．０３ｃ
ｍ3・ｍｍ／ｍ2・２４ｈ・ａｔｍであり、一般的な高分
子フィルムに比べても高いガスバリア性を有し、特に酸
素バリア性については、一般的な高分子フィルムのポリ
エチレンテレフタレート（１．０ｃｍ3・ｍｍ／ｍ2・２
４ｈ・ａｔｍ）をはるかに上回り、既存フィルムで最も
高い酸素バリア性をもつエバールに匹敵する。さらに、
本発明の成型体は、光学的にも遮光物質を混ぜ込むこと
なく波長３００ｎｍ以下の紫外領域の光について完全な
遮光性を有する。したがって、本発明のシート状・フィ
ルム状成型体は、食品、医薬品、化成品、飼料、農業な
ど幅広い分野に適用することができる。(Properties and physical properties of molded article having antistatic ability) The molded article of the present invention has excellent properties such as an ultraviolet ray shielding function, a moisture proof function and a gas barrier function in addition to the antistatic function. ASTM D257 for the antistatic ability of the molded product
Surface resistivity when measured based on the measurement method according to
At 3 ° C. and 50% RH, 10 9 Ω or less, for example, 10 6 Ω
A low resistance value of 〜１０10 9 Ω is preferred. Regarding the gas barrier properties of the film-shaped molded product, oxygen, hydrogen, carbon dioxide,
The gas permeability coefficient of nitrogen is determined by oxygen according to JIS K7126.
The B method (Mocon method), carbon dioxide gas was measured according to the Mocon method, and hydrogen and nitrogen were measured according to JIS K7126 A method. The oxygen permeability coefficient was 0.003 cm 3 · mm / m 2 · 24ha.
tm, hydrogen permeability coefficient is 0.77 cm 3 · mm / m 2 · 24
h · atm, CO2 permeability coefficient is 0.15cm 3 · m
m / m 2 · 24h · atm , nitrogen permeability coefficient 0.03c
m 3 · mm / m 2 · 24 h · atm, and has a higher gas barrier property than a general polymer film. In particular, regarding the oxygen barrier property, polyethylene terephthalate (1. 0cm 3・ mm / m 2・ 2
4 h.atm), which is comparable to EVAL which has the highest oxygen barrier property of existing films. further,
The molded article of the present invention has a perfect light shielding property for light in the ultraviolet region having a wavelength of 300 nm or less without optically mixing a light shielding substance. Therefore, the sheet-like / film-like molded article of the present invention can be applied to a wide range of fields such as food, pharmaceuticals, chemical products, feed, and agriculture.
【００２０】また、本発明のカプセル形状の成型体は、
既存のゼラチンカプセルやＨＰＭＣ（ヒドロキシプロピ
ルメチルセルロース）カプセルに比較して、上記のよう
に、帯電防止機能の他、紫外線遮光機能、防湿機能、ガ
スバリア機能等優れた物性を有し、可食性でハンドリン
グもよく、カプセルの帯電によるブロッキングや粉体の
飛散・付着等の前記問題を解決することができる。また
本発明の帯電防止剤を用いた流動層造粒成型において
は、除電バグフィルター等でコロナ放電による除電を行
うことなく、流動層造粒によるコーティング及び造粒を
行うことができ、紫外線防止機能・低帯電性・防湿性・
ガスバリア性に優れた顆粒・造粒物のコーティング物を
調製することができる。Further, the capsule-shaped molded article of the present invention comprises:
Compared to existing gelatin capsules and HPMC (hydroxypropyl methylcellulose) capsules, as described above, it has excellent physical properties such as ultraviolet light shielding function, moisture proof function, gas barrier function, etc. The above problems such as blocking due to charging of the capsule and scattering and adhesion of powder can be solved. In the fluidized-bed granulation molding using the antistatic agent of the present invention, coating and granulation by fluidized-bed granulation can be performed without performing charge elimination by corona discharge using a charge elimination bag filter or the like.・ Low electrification ・ Dampproof ・
A coating of granules and granules having excellent gas barrier properties can be prepared.
【００２１】[0021]
【実施例】以下に、本発明を実施例により詳細に説明す
るが、本発明の技術的範囲はこれらの実施例に限定され
るものではない。なお、実施例中に示された酵母菌体重
量は、すべて実状態での重量（ドライウエイト）であ
る。 実施例１（酸処理酵母細胞壁画分の調製） ビール工場よりビール酵母スラリ―を入手し、４５００
ｒｐｍ、１０分の条件で遠心分離して得られた泥状生酵
母を固形分が５重量％になるように水に懸濁した。この
懸濁物を５０℃、１７時間の反応条件で自己消化させた
後、再度遠心分離して、可溶性菌体内成分を除去した自
己消化残さを酵母細胞壁画分とした。次に、この酵母細
胞壁画分の固形分が５％重量になるように０．１Ｎ塩酸
に懸濁して、８０℃、２０分間酸処理した後、４５００
ｒｐｍ、１５分の条件で遠心分離し、可溶化分を除去し
て得られた残さを酸処理酵母細胞壁画分とした。EXAMPLES The present invention will be described below in detail with reference to examples, but the technical scope of the present invention is not limited to these examples. All yeast cell weights shown in the examples are weights (dry weights) in the actual state. Example 1 (Preparation of acid-treated yeast cell wall fraction) Beer yeast slurry was obtained from a beer factory and 4500
The muddy yeast obtained by centrifugation at 10 rpm for 10 minutes was suspended in water so that the solid content was 5% by weight. This suspension was autolyzed under the reaction conditions of 50 ° C. and 17 hours, and then centrifuged again to obtain an autolysed residue from which soluble intracellular components had been removed to obtain a yeast cell wall fraction. Next, the yeast cell wall fraction was suspended in 0.1 N hydrochloric acid so that the solid content was 5% by weight, and subjected to an acid treatment at 80 ° C. for 20 minutes.
Centrifugation was performed at 15 rpm for 15 minutes to remove the solubilized components, and the resulting residue was used as an acid-treated yeast cell wall fraction.
【００２２】実施例２（フィルム表面抵抗の測定） 各種フィルムについて、一般に帯電性と相関があるとい
われる表面固有抵抗をＡＳＴＭ Ｄ２５７の方法に従
い、２３℃、５０％ＲＨの条件にて測定した。実施例１
で調製した酸処理酵母細胞壁画分を水に分散させ、固形
分８重量％のスラリーとし、４０℃において自然乾燥す
る被膜成型により、厚さ５０μｍのフィルムを調製し、
本件フィルムとした。［本件フィルム１］はグリセリン
を添加することなくｐＨを４．０に調整したもの、［本
件フィルム２］はグリセリンを酸処理酵母細胞壁の固形
分に対して３０重量％添加しｐＨを３．０に調整したも
の、［本件フィルム３］はグリセリンを酸処理酵母細胞
壁の固形分に対して２０重量％添加しｐＨを３．０に調
整したもの、［本件フィルム４］はグリセリンを酸処理
酵母細胞壁の固形分に対して２０重量％添加しｐＨを
１．０に調整したもの、からそれぞれ調製したフィルム
である。Example 2 (Measurement of Film Surface Resistance) With respect to various films, the surface resistivity, which is generally said to have a correlation with the chargeability, was measured at 23 ° C. and 50% RH according to the method of ASTM D257. Example 1
The acid-treated yeast cell wall fraction prepared in the above was dispersed in water to obtain a slurry having a solid content of 8% by weight, and a film having a thickness of 50 μm was prepared by coating molding which was naturally dried at 40 ° C.
This is the film. [Film 1] was prepared by adjusting the pH to 4.0 without adding glycerin. [Film 2] was added to glycerin by 30% by weight based on the solid content of the acid-treated yeast cell wall, and the pH was adjusted to 3.0. [Film 3] was prepared by adding 20% by weight of glycerin to the solid content of the acid-treated yeast cell wall to adjust the pH to 3.0. [Film 4] was prepared by adding glycerin to the acid-treated yeast cell wall. These films were prepared from those obtained by adding 20% by weight based on the solid content of and adjusting the pH to 1.0.
【００２３】また、対照として、本件フィルムと同様に
調製したＨＰＭＣフィルム、グリセリンを３０重量％添
加し、ｐＨを３．０に調整したものから調製したＨＰＭ
Ｃフィルム及び本件フィルムと同様に調製したゼラチン
フィルムと、高分子系フィルムをコロナ放電により導電
化率を高めた市販の帯電防止フィルムを用いた。表面固
有抵抗Ωの比較結果を表２に示す。なお、対照の市販フ
ィルムの測定方法のみＪＩＳｋ−６９１１（湿度６５
％）を用いたため、ＡＳＴＭでは若干高めとなってい
る。表２に示されるように、本件フィルムは対照のフィ
ルムに比較し、有意に抵抗値が低く帯電性も低いことが
わかる。また、本件フィルムの中でも、グリセリンを添
加したものがより低い抵抗値を示すことがわかった。Further, as a control, an HPMC film prepared in the same manner as the present film, HPM prepared from a glycerin-added 30% by weight and pH adjusted to 3.0.
A C film, a gelatin film prepared in the same manner as the present film, and a commercially available antistatic film obtained by increasing the conductivity of a polymer film by corona discharge were used. Table 2 shows the comparison results of the surface resistivity Ω. In addition, JISk-6911 (humidity 65
%), It is slightly higher in ASTM. As shown in Table 2, it can be seen that the film of the present invention has significantly lower resistance and lower chargeability than the control film. It was also found that, among the films of the present invention, those to which glycerin was added exhibited a lower resistance value.
【００２４】[0024]
【表２】 [Table 2]
【００２５】実施例３（フィルム帯電圧減衰の測定） 各種フィルムについて、印加電圧８ｋＶ、印加時間３０
秒で帯電させたフィルムの電位の半減期及びピークの電
位を、２３℃、５０％ＲＨの条件にて測定した。各種フ
ィルムとしては、実施例２において用いたフィルムに加
えて、［本件フィルム５］として、酸処理酵母細胞壁画
分の固形分を８重量％及びグリセリンを酸処理酵母細胞
壁画分の固形分に対して１０重量％添加し、ｐＨを４．
０に調整したものから調製したフィルムを用いた。ま
た、この帯電圧減衰の測定には、スタチックオネストメ
ーター（シシド静電気社製）を用いた。結果を表３に示
す。表３に示されるように、本件フィルムは対照のフィ
ルムに比較し、電位・半減期とも“０”と測定され、帯
電圧減衰において有意に優れていることがわかった。Example 3 (Measurement of Voltage Attenuation of Film Charge) For various films, an applied voltage of 8 kV and an application time of 30
The half-life and the peak potential of the potential of the film charged in seconds were measured at 23 ° C. and 50% RH. As the various films, in addition to the films used in Example 2, [the present film 5], the solid content of the acid-treated yeast cell wall fraction was 8% by weight, and glycerin was added to the solid content of the acid-treated yeast cell wall fraction. 10% by weight to adjust the pH to 4.
A film prepared from one adjusted to 0 was used. In addition, a static honest meter (manufactured by Shisido Electrostatic Co., Ltd.) was used for the measurement of the charged voltage decay. Table 3 shows the results. As shown in Table 3, the film of the present invention was measured to have a potential and a half-life of "0" as compared with the control film, and was found to be significantly superior in the charge decay.
【００２６】[0026]
【表３】 [Table 3]
【００２７】実施例４（カプセルの帯電電位の測定） ２３℃、５０％ＲＨの条件下、各種カプセル各１５０個
を１７５×２４５ｍｍのステンレス製のバットに一様に
置き、３０ｍｍの振幅で２００回／分の周期で振動を与
え、振動開始５分後の振動状体及び振動停止１分後の静
止状態における、カプセルに発生した静電気による帯電
電位を電位測定計（シシド電気社製「ＳＴＡＴＩＲＯＮ
Ｍ２」）を用いてカプセルから５０ｍｍの距離から測
定した。各種カプセルとしては、実施例１で調製した酸
処理酵母細胞壁画分の固形分を１５重量％及びグリセリ
ンを１０重量％添加しｐＨを４．０に調整したスラリー
状の帯電防止剤に、３号カプセルと同等の大きさの型を
ディッピングし、４０℃で乾燥することで水分を蒸発さ
せ作製した［本件カプセル］と、対照としての市販ゼラ
チンカプセル及び市販ＨＰＭＣカプセルとを用いた。結
果を表４に示す。表４に示されているように、本件カプ
セルの帯電電位は“０”であり、対照品である市販ゼラ
チンカプセル及び市販ＨＰＭＣカプセルに比べ、帯電防
止機能において有意に優れていることがわかった。ま
た、温度５０℃、湿度７０％の条件下で、市販ゼラチン
カプセル及び市販ＨＰＭＣカプセルがべたつくのに対
し、本件カプセルはべたつきがなく、防湿性の面でも優
れていることがわかった。Example 4 (Measurement of Capsule Charging Potential) Under conditions of 23 ° C. and 50% RH, 150 capsules of each type were uniformly placed in a 175 × 245 mm stainless steel vat, and 200 times with an amplitude of 30 mm. / Vibration at a cycle of / min, and the static potential generated in the capsule in the vibrating body 5 minutes after the start of the vibration and in the stationary state 1 minute after the stop of the vibration was measured by a potentiometer (“STATIRON” manufactured by Shishido Electric Co., Ltd.).
M2 ") from a distance of 50 mm from the capsule. Various capsules were prepared by adding 15% by weight of solid content of the acid-treated yeast cell wall fraction prepared in Example 1 and adding 10% by weight of glycerin to adjust the pH to 4.0 with a slurry-like antistatic agent. A capsule having the same size as the capsule was dipped and dried at 40 ° C. to evaporate water to prepare [the present capsule], and a commercial gelatin capsule and a commercial HPMC capsule as controls were used. Table 4 shows the results. As shown in Table 4, the charging potential of the present capsule was "0", and it was found that the capsule was significantly superior in antistatic function as compared with the commercial gelatin capsule and the commercial HPMC capsule as control products. Under the conditions of a temperature of 50 ° C. and a humidity of 70%, the commercially available gelatin capsules and the commercially available HPMC capsules were sticky, whereas the capsules of the present invention were found to be non-sticky and excellent in moisture-proof properties.
【００２８】[0028]
【表４】 [Table 4]
【００２９】実施例５（流動層造粒） コーティング剤として、本発明の帯電防止剤と対照とし
てのエチルセルロースを用い、結晶セルロース製球形顆
粒 (旭化成社製「セルフィア」)に対して、転動流動層
コーティング装置（パウレック製「マルチプレックスＭ
Ｐ−０１型」）で流動層コーティングを行った。コーテ
ィング量はともに、結晶セルロース製球形顆粒に対し２
０重量％とした。本発明の帯電防止剤からなるコーティ
ング剤としては、実施例１で調製した酸処理酵母細胞壁
画分の固形分を６〜１０重量％及びグリセリンを０．３
〜３．０重量％添加し、ｐＨを３．０〜４．５に調整し
たスラリー状の帯電防止剤を用いた。また、対照のエチ
ルセルロースからなるコーティング剤としては、エチル
セルロース１．０〜８．０重量％でエタノール中に溶解
させて調製したスラリーを用いた。Example 5 (Fluidized bed granulation) As the coating agent, the antistatic agent of the present invention and ethylcellulose as a control were used, and tumbling flow was performed on spherical granules made of crystalline cellulose ("Selfia" manufactured by Asahi Kasei Corporation). Layer Coating Equipment (Polex “Multiplex M”
P-01 type "). The coating amount was 2 to the spherical cellulose granules.
0% by weight. As the coating agent comprising the antistatic agent of the present invention, the solid content of the acid-treated yeast cell wall fraction prepared in Example 1 was 6 to 10% by weight, and glycerin was 0.3% by weight.
To 3.0% by weight, and a slurry-like antistatic agent whose pH was adjusted to 3.0 to 4.5 was used. In addition, a slurry prepared by dissolving ethyl cellulose in ethanol at 1.0 to 8.0% by weight in ethanol was used as a coating agent comprising ethyl cellulose as a control.
【００３０】コーティング中、転動流動層コーティング
装置の壁面の状態を目視により観察行った結果、壁面は
十分乾燥していたが、対照のエチルセルロースの場合、
帯電によるコーティング顆粒の壁面への付着が漸次増加
し堆積していった。これに対し、本発明の帯電防止剤の
場合、コーティング顆粒の壁面への付着はほとんど見ら
れず、壁面付着において有為に差が認められた。また、
コーティング顆粒を顕鏡したところ、対照のエチルセル
ロースの場合、顆粒同士の帯電による結着で発生する２
つ又は３つの顆粒が繋がった多連コーティング顆粒や、
未コーティング顆粒が見られたが、本発明の帯電防止剤
の場合、多連コーティング顆粒や未コーティング顆粒は
見い出せなかった。そして、コーティング工程に続く乾
燥工程に入っても、本発明の帯電防止剤の場合には帯電
によるコーティング顆粒同士の付着は見られなかった。During the coating, the condition of the wall surface of the tumbling fluidized bed coating apparatus was visually observed. As a result, the wall surface was sufficiently dried.
Adhesion of the coated granules to the wall surface due to charging gradually increased and accumulated. In contrast, in the case of the antistatic agent of the present invention, adhesion of the coated granules to the wall surface was hardly observed, and a significant difference was observed in the adhesion to the wall surface. Also,
When the coated granules were observed under a microscope, in the case of the control ethyl cellulose, the particles were generated due to the binding due to the electrification of the granules.
One or three granules connected to multiple coated granules,
Although uncoated granules were observed, in the case of the antistatic agent of the present invention, multiple coated granules and uncoated granules were not found. Then, even in the drying step following the coating step, adhesion of the coated granules due to charging was not observed in the case of the antistatic agent of the present invention.
【００３１】[0031]
【発明の効果】本発明の帯電防止剤を用いて成型した成
型体は、表面固有抵抗が２３℃、ＲＨ５０％において１
０6〜１０9Ωの低帯電性を示し、優れた帯電防止機能を
備えている他、紫外線遮光機能、防湿機能、ガスバリア
機能等優れた性状・物性を有している。したがって、本
発明のシート状・フィルム状成型体は、食品、医薬品、
飼料、農業など幅広い分野に適用することができる。ま
た、本発明のカプセル形状の成型体は、帯電防止機能の
他、紫外線遮光機能、防湿機能、ガスバリア機能等優れ
た物性を有し、可食性でハンドリングもよく、カプセル
の帯電によるブロッキングや粉体の飛散・付着等の問題
がない。さらに、本発明の帯電防止剤を用いて顆粒をコ
ーティング成型する場合、流動層造粒装置壁面への付着
がなく、顆粒同士の帯電による繋がった多連コーティン
グ顆粒や、未コーティング顆粒の発生等のコーティング
不良を防止することができる。The molded article molded using the antistatic agent of the present invention has a surface resistivity of 23 ° C. and an RH of 50%.
0 indicates 6 to 10 9 Omega low chargeability, except that has excellent antistatic properties, ultraviolet light shielding function, moistureproof function, a gas barrier function such excellent properties, physical properties. Therefore, the sheet-shaped or film-shaped molded article of the present invention is used for foods, pharmaceuticals,
It can be applied to a wide range of fields such as feed and agriculture. In addition, the capsule-shaped molded article of the present invention has excellent physical properties such as an ultraviolet light shielding function, a moisture proof function, a gas barrier function, and the like, in addition to an antistatic function, is edible and has good handling, and is capable of blocking and powdering by charging the capsule. There is no problem such as scattering and adhesion. Furthermore, when coating and molding granules using the antistatic agent of the present invention, there is no adhesion to the fluidized bed granulator wall surface, multiple coated granules connected by charging of granules, and generation of uncoated granules, etc. Coating defects can be prevented.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ｃ０８Ｊ 7/04 ＣＥＺ Ｃ０８Ｊ 7/04 ＣＥＺＤ ４Ｊ００２ Ｃ０８Ｋ 5/04 Ｃ０８Ｋ 5/04 Ｃ０８Ｌ 5/00 Ｃ０８Ｌ 5/00 89/00 89/00 // Ｃ１２Ｐ 19/04 Ｃ１２Ｐ 19/04 Ｚ Ｆターム(参考） 4B064 AF11 CA06 CA21 CC03 CD21 DA16 4F006 AA02 AA11 AA31 AB02 BA07 DA04 4F070 AA62 AC36 AC40 AC43 AC72 AC93 AC94 AE02 DA56 DA58 DC04 DC06 DC13 4F071 AA08 AA70 AA71 AC05 AC10 AC12 AE04 AH19 BA07 BB02 BC01 4F100 AG00 AJ04 AJ09B AK01 AT00A BA02 BA07 DE01 DE04 EH46B EH462 JG03 JG03B YY00B 4J002 AB052 AD001 AD012 AE002 EC056 EF006 EH036 EH056 EN116 FD022 FD026 FD101 GH02 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) C08J 7/04 CEZ C08J 7/04 CEZD 4J002 C08K 5/04 C08K 5/04 C08L 5/00 C08L 5/00 89/00 89/00 // C12P 19/04 C12P 19/04 ZF term (reference) 4B064 AF11 CA06 CA21 CC03 CD21 DA16 4F006 AA02 AA11 AA31 AB02 BA07 DA04 4F070 AA62 AC36 AC40 AC43 AC72 AC93 AC94 AE02 DA56 DA58 DC04 DC06 DC13 4F071 AA08 AA70 AA71 AC05 AC10 AC12 AE04 AH19 BA07 BB02 BC01 4F100 AG00 AJ04 AJ09B AK01 AT00A BA02 BA07 DE01 DE04 EH46B EH462 JG03 JG03B YY00B 4J002 AB052 AD001 AD012 AE002 EC056 FD006 EF006 EF006 E0116 FD006
Claims (8)
を除去した菌体残さを酸性水溶液で処理し、さらに可溶
化物を除去した残さからなる酸処理酵母細胞壁画分を主
成分とすることを特徴とする帯電防止剤。1. A method comprising treating a cell residue obtained by removing a soluble intracellular component from an enzyme-treated yeast with an acidic aqueous solution and further comprising an acid-treated yeast cell wall fraction comprising the residue obtained by removing a solubilized material as a main component. Characteristic antistatic agent.
であることを特徴とする請求項１記載の帯電防止剤。2. The antistatic agent according to claim 1, wherein the antistatic agent further contains a plasticizer.
て成型したことを特徴とする帯電防止能を有する成型
体。3. A molded article having antistatic ability, molded using the antistatic agent according to claim 1.
ティングすることにより得られることを特徴とする請求
項３記載の帯電防止能を有する成型体。4. The molded product having antistatic ability according to claim 3, wherein the molded product is obtained by coating the substrate with a single or multiple layers of an antistatic agent.
たことを特徴とする請求項３又は４記載の帯電防止能を
有する成型体。5. A molded article having an antistatic ability according to claim 3, wherein the molded article is molded into a sheet shape or a film shape.
請求項４記載の帯電防止能を有する成型体。6. The molded article having an antistatic ability according to claim 4, wherein the molded article is molded into a granular shape.
する請求項３記載の帯電防止能を有する成型体。7. The molded article having antistatic ability according to claim 3, wherein the molded article is molded into a capsule shape.
抗が、１０6〜１０9Ωであることを特徴とする請求項３
〜７のいずれか記載の帯電防止能を有する成型体。8. The surface resistivity at 23 ° C. and 50% RH is 10 6 to 10 9 Ω.
8. The molded article having an antistatic ability according to any one of items 7 to 7.
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|---|---|---|---|
| JP2000225146A JP4656553B2 (en) | 2000-07-26 | 2000-07-26 | Antistatic agent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000225146A JP4656553B2 (en) | 2000-07-26 | 2000-07-26 | Antistatic agent |
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| Publication Number | Publication Date |
|---|---|
| JP2002038133A true JP2002038133A (en) | 2002-02-06 |
| JP4656553B2 JP4656553B2 (en) | 2011-03-23 |
Family
ID=18718970
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000225146A Expired - Fee Related JP4656553B2 (en) | 2000-07-26 | 2000-07-26 | Antistatic agent |
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| Country | Link |
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| JP (1) | JP4656553B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1454534A4 (en) * | 2001-11-15 | 2006-02-22 | San Ei Gen Ffi Inc | Microcapsules and oral compositions containing the same |
| JP2011103788A (en) * | 2009-11-13 | 2011-06-02 | Kirin Kyowa Foods Co Ltd | Edible film for packaging food |
| KR20210027691A (en) * | 2019-09-02 | 2021-03-11 | (주) 그린메이커 | artificial grass with anti-electrification |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4956000A (en) * | 1972-10-04 | 1974-05-30 | ||
| JPS5345385A (en) * | 1976-10-07 | 1978-04-24 | Idemitsu Kosan Co | Process for manufacturing film made of germ from microorganism |
| JPH08319474A (en) * | 1995-05-25 | 1996-12-03 | Teika Corp | Antistatic agent comprising polysaccharide |
| JPH08319475A (en) * | 1995-05-25 | 1996-12-03 | Teika Corp | Antistatic agent comprising polysaccharide |
| JPH0913011A (en) * | 1995-06-28 | 1997-01-14 | Teika Corp | Polysaccharide-based antistatic agent |
| JPH11246667A (en) * | 1998-03-03 | 1999-09-14 | Nicca Chem Co Ltd | Production of casein derivative and treatment agent containing the same and intended for synthetic fiber |
-
2000
- 2000-07-26 JP JP2000225146A patent/JP4656553B2/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4956000A (en) * | 1972-10-04 | 1974-05-30 | ||
| JPS5345385A (en) * | 1976-10-07 | 1978-04-24 | Idemitsu Kosan Co | Process for manufacturing film made of germ from microorganism |
| JPH08319474A (en) * | 1995-05-25 | 1996-12-03 | Teika Corp | Antistatic agent comprising polysaccharide |
| JPH08319475A (en) * | 1995-05-25 | 1996-12-03 | Teika Corp | Antistatic agent comprising polysaccharide |
| JPH0913011A (en) * | 1995-06-28 | 1997-01-14 | Teika Corp | Polysaccharide-based antistatic agent |
| JPH11246667A (en) * | 1998-03-03 | 1999-09-14 | Nicca Chem Co Ltd | Production of casein derivative and treatment agent containing the same and intended for synthetic fiber |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1454534A4 (en) * | 2001-11-15 | 2006-02-22 | San Ei Gen Ffi Inc | Microcapsules and oral compositions containing the same |
| JP2011103788A (en) * | 2009-11-13 | 2011-06-02 | Kirin Kyowa Foods Co Ltd | Edible film for packaging food |
| KR20210027691A (en) * | 2019-09-02 | 2021-03-11 | (주) 그린메이커 | artificial grass with anti-electrification |
| KR102248247B1 (en) * | 2019-09-02 | 2021-05-06 | (주) 그린메이커 | artificial grass with anti-electrification |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4656553B2 (en) | 2011-03-23 |
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