JP2002028473A - Method for manufacturing microcapsule film of which is made airtight - Google Patents

Abstract

PROBLEM TO BE SOLVED: To make a film of a microcapsule produced by coacervation method airtight. SOLUTION: The microcapsule film of which is made airtight can be obtained by coating the microcapsule produced by the coacervation method with a saccharide and/or a saccharide alcohol. As the saccharide or the saccharide alcohol, glucose, sucrose, maltose, trehalose, sorbitol, multitol or the like can be cited. In the microcapsule of this invention, volatilization of a core substance being an oily liquid or deterioration and discoloring by air oxidation can be prevented. In particular, when oily perfume is used as the core substance, perfume components are excellently held and when medicine components or the like susceptible to oxidation are used, preservation stability thereof is excellent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing microcapsules in which a film is hermetically sealed. More specifically, the present invention relates to a method for producing a hermetically sealed microcapsule, which comprises coating a microcapsule prepared by a coacervation method with a saccharide and / or a sugar alcohol.

[0002]

2. Description of the Related Art Conventionally, as a method for producing microcapsules, a coacervation method using a gelatin-gum arabic system or the like has been known. The coacervation method can efficiently and easily encapsulate an oily liquid, and thus is suitable for microencapsulating a viscous oily liquid and pulverizing it. Further, microcapsules produced by the coacervation method have a feature of being easily soluble in water and the like, and thus are particularly suitably used as microcapsulation methods in the fields of foods, flavors, and medicine. However, microcapsules prepared by the coacervation method are:
There is a defect that the hermeticity of the capsule film is insufficient, the core substance is volatilized during storage, and deterioration or discoloration due to air oxidation occurs. In order to compensate for such a defect, there is known a method in which microcapsules are treated with ethanol, tannic acid, potassium alum, or the like to crosslink gelatin and harden the film. According to these methods, volatilization and alteration of the core substance can be prevented to some extent, but the effect is not always sufficient, and a microcapsule having more excellent airtightness of the film is required.

[0003]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a microcapsule in which a capsule film of a microcapsule prepared by a coacervation method is hermetically sealed to prevent volatilization and deterioration of a core substance during storage. And

[0004]

The object of the present invention can be attained by coating microcapsules prepared by the coacervation method with sugars and / or sugar alcohols. In practicing the present invention, the microcapsules are prepared by a coacervation method known per se. For example, an oily core substance is added to an aqueous solution of a film-forming material such as gelatin at 45 to 60 ° C., and a coacervating agent such as a saline solution is added under stirring, and the mixture is gradually cooled to a periphery of oil particles. The coacervate is adsorbed to form and harden a film. The microcapsules formed from the mixture are separated by filtration or the like.

[0005] The core substance contained in the capsule is not particularly limited, but the advantage of the present invention is exhibited when an oily liquid which is easily volatilized or susceptible to air oxidation is used. The core substance used in the present invention is not particularly limited as long as it is an oily liquid.For example, corn oil, soybean oil, rapeseed oil, fish oil, lard, animal and vegetable oils such as head, α-linolenic acid, eicosapentaenoic acid, Docosahexaenoic acid (DH
Fatty acids such as A), fat-soluble vitamins, oily and emulsified flavors, and the like can be mentioned, and preferably fat-soluble vitamins, oily and emulsified flavors, and particularly preferably oily flavors are used.

The film-forming material used in the present invention is not particularly limited, but gelatin is preferably used. As gelatin, unpurified gelatin,
Examples thereof include purified gelatin, acid-decomposed gelatin, and enzyme-decomposed gelatin, and are not particularly limited. Preferably, purified gelatin is used. The weight ratio between the core substance and the gelatin is not particularly limited, but is preferably 10%.
0: 1 to 100: 100, more preferably 100: 10
It is used in the range of ~ 100: 60. This ratio is 100:
If it is less than 1, the film of the microcapsule is thin and a problem may occur in the strength.
The coating of the microcapsules is thick and may adversely affect the expression of the core substance.

As the coacervating agent used in the present invention, those used for ordinary coacervating can be used without any particular limitation. In particular, electrolyte substances consisting of gum arabic, carrageenan, CMCs, organic or inorganic salts, for example, salts with cations such as sodium chloride, potassium chloride, magnesium chloride, ammonium chloride, sulfates, phosphates, carbonates And salts having an anion such as acetate. Further, a liquid substance which is a water-soluble liquid and in which the film forming material therein is less soluble than water, for example, alcohols such as ethanol and propanol can be used.

[0008] The method of drying the microcapsules formed by coacervation is not particularly limited, and examples include spray drying, reduced pressure drying, freeze drying, and fluidized bed drying. Preferably, it is dried by a fluidized bed drying method using a drying aid such as starch, cellulose fine powder, and silicon dioxide which are hardly soluble in water.

In the present invention, the saccharide used for coating the microcapsule film is not particularly limited as long as it is a low-molecular saccharide, and a monosaccharide or an oligosaccharide is used.
Examples of monosaccharides include glucose, and examples of oligosaccharides include galactose, sucrose, maltose, lactose, lactose, trehalose, pullulan, starch syrup, cyclodextrin, and the like.
These can be used alone or in combination of two or more. Preferably one or two of sucrose, lactose, maltose, lactose and trehalose
Use combinations of more than one species. The yeast cell wall is a sugar containing about 30% β-glucan as a main component and can be used as the coating agent of the present invention. Examples of sugar alcohols include sorbitol, xylitol, maltitol.

The amount of the saccharide and / or sugar alcohol is not particularly limited, but is preferably 1% to 100% by weight, more preferably 10% to 5% by weight of the coating material.
0% by weight is used. If it exceeds 100%, the fluidity of the microcapsules will be impaired, and the encapsulation rate will decrease. If it is less than 1%, the airtightness of the film is insufficient.

The coating with a saccharide and / or a sugar alcohol can be performed at any stage before or after the drying of the microcapsules as long as it is after the step of forming the microcapsules. It is preferably coated after drying the microcapsules. As a coating method, the saccharide and / or sugar alcohol is added as it is or as an aqueous solution having an arbitrary concentration. Preferably, the saccharide and / or sugar alcohol are in a liquid state, and in a solid state, 30% by weight. It is coated by spraying in the state of an aqueous solution. In this case, if it is performed simultaneously with the drying step of the microcapsules, it is economically advantageous without increasing the number of manufacturing steps.

The production method of the present invention is suitably carried out, for example, by the following method. An oily liquid such as flavor oil is added to the aqueous gelatin solution at 45 to 60 ° C., an aqueous edible salt solution is added with stirring, and the mixture is gradually cooled to adsorb coacervate around the emulsion particles and harden. The formed microcapsules are easily removed by filtration or the like, dried with a drying aid such as starch if necessary, and then sprayed with a solution of a saccharide and / or a sugar alcohol, followed by drying. The microcapsules obtained in this way have fluidity,
Oily liquids such as flavor oils have properties that are stable over time. Next, the present invention will be described more specifically with reference to examples.

[0013]

EXAMPLES Example 1 30 g of rapeseed hardened oil in which 5% ginger oil was dissolved
Was added to 60 mL of a 10% aqueous gelatin solution heated to 50 ° C. to form oil droplets. 70 mL of water was added, and then a salt solution obtained by dissolving 0.6 g of sodium metaphosphate in 60 mL of water was added dropwise. After completion of the addition, the gelatin solution was gradually cooled to form a coacervate. The obtained coacervate was separated by filtration and air-dried using starch as a drying aid to obtain 45 g of microcapsules (Control product 1). 5 g of an aqueous solution containing 1.5 g of maltose was sprayed on 145 g of this control product, followed by natural drying to obtain 46 g of the microcapsules of the present invention.

Example 2 Using trehalose instead of maltose in Example 1,
47 g of the microcapsules of the present invention were obtained. Example 3 47 g of the microcapsules of the present invention were obtained by using glucose in place of maltose in Example 1. Example 4 Using the yeast cell wall in place of maltose of Example 1, 45 g of the microcapsules of the present invention were obtained.

Test Example 1 Control product 1 and microcapsules of Examples 1 to 4
After storage at 1 ° C. for one month, each microcapsule was dissolved in warm water, the released oil was subjected to GC quantitative analysis, and the residual ratio of ginger aroma components was measured. Table 1 shows the results.

[0016]

[Table 1] From the results in Table 1 above, it is clear that the product of the present invention retains the aroma component as compared with the control product 1, and is effective in preventing the volatilization of the oily liquid.

REFERENCE EXAMPLE Medium chain fatty acid triglyceride 30 in which 10% DHA is dissolved
g was added to 60 mL of a 10% aqueous gelatin solution heated to 50 ° C. to form oil droplets. 70 mL of water was added, and then a salt solution obtained by dissolving 0.6 g of sodium metaphosphate in 60 mL of water was added dropwise. After completion of the addition, the gelatin solution was gradually cooled to form a coacervate. The obtained coacervate was separated by filtration and air-dried using starch as a drying aid to obtain 47 g of microcapsules (control product 2).

Example 5 Medium chain fatty acid triglyceride 30 in which 10% DHA was dissolved
g was added to 60 mL of a 10% aqueous gelatin solution heated to 50 ° C. to form oil droplets. 70 mL of water was added, and then a salt solution obtained by dissolving 0.6 g of sodium metaphosphate in 60 mL of water was added dropwise. After completion of the addition, the gelatin solution was gradually cooled to form a coacervate. The obtained coacervate was filtered off, and an aqueous solution 5 containing 1.5 g of trehalose was added.
g was sprayed. The starch was air-dried using starch as a drying aid to obtain 40 g of the microcapsules of the present invention.

Example 6 Medium chain fatty acid triglyceride 30 in which 10% DHA was dissolved
g was added to 60 mL of a 10% aqueous gelatin solution heated to 50 ° C. to form oil droplets. 70 mL of water was added, and then a salt solution obtained by dissolving 0.6 g of sodium metaphosphate in 60 mL of water was added dropwise. After completion of the addition, the gelatin solution was gradually cooled to form a coacervate. The resulting coacervate was filtered off and dried using starch as a drying aid.
5 g of an aqueous solution containing 1.5 g of sorbitol was sprayed on the dried microcapsules. Using starch as a drying aid
By air drying, the microcapsules of the present invention
3 g were obtained.

Example 7 Medium-chain triglyceride 30 containing 10% DHA
g was added to 60 mL of a 10% aqueous gelatin solution heated to 50 ° C. to form oil droplets. 70 mL of water was added, and then a salt solution obtained by dissolving 0.6 g of sodium metaphosphate in 60 mL of water was added dropwise. After completion of the addition, the gelatin solution was gradually cooled to form a coacervate. The obtained coacervate was separated by filtration, and an aqueous solution 5 containing 0.25 g of yeast cell wall was obtained.
g was sprayed. The starch was air-dried using starch as a drying aid to obtain 40 g of the microcapsules of the present invention.

Test Example 2 Control product 2 and the microcapsules of Examples 5 to 7
After heating and abuse storage for 3 weeks at ℃, D from microcapsules
HA was recovered, and each POV value (peroxide value) was measured. Table 2 shows the results of comparison between the case of abused storage and the case of refrigerated storage at 5 ° C. for 3 weeks.

[0022]

[Table 2] From the results shown in Table 2 above, the microcapsules of the present invention were compared with the microcapsules of control product 2 in DHA during abuse storage.
It can be seen that the increase rate of the POV value was suppressed and the oxidation of DHA was prevented.

[0023]

According to the present invention, there is provided a method for producing a microcapsule in which a film is hermetically sealed. In the microcapsule of the present invention, since the film is coated with a saccharide and / or a sugar alcohol, the film of the capsule is airtight, and deterioration and discoloration due to volatilization of the oily liquid core material and air oxidation are prevented. Is done. Therefore, when an oily fragrance is used as the core substance, the retention of the fragrance component is excellent,
Also, when a pharmaceutical component or the like which is easily oxidized is used, the storage stability is excellent.

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Claims (5)

[Claims] 1. A method for producing a hermetically sealed microcapsule, comprising coating a microcapsule prepared by a coacervation method with a saccharide and / or a sugar alcohol. 2. The method for producing microcapsules according to claim 1, wherein the saccharide is one or a combination of two or more selected from the group consisting of monosaccharides, oligosaccharides and yeast cell walls. 3. The method for producing microcapsules according to claim 2, wherein the monosaccharide is glucose. 4. The method for producing microcapsules according to claim 2, wherein the oligosaccharide is one or a combination of two or more selected from galactose, sucrose, maltose, lactose, trehalose, pullulan, syrup and cyclodextrin. 5. The method for producing microcapsules according to claim 1, wherein the sugar alcohol is one or a combination of two or more selected from sorbitol, xylitol and maltitol.