JP2002005930A - Saliva flow measuring test paper - Google Patents
Saliva flow measuring test paperInfo
- Publication number
- JP2002005930A JP2002005930A JP2000181142A JP2000181142A JP2002005930A JP 2002005930 A JP2002005930 A JP 2002005930A JP 2000181142 A JP2000181142 A JP 2000181142A JP 2000181142 A JP2000181142 A JP 2000181142A JP 2002005930 A JP2002005930 A JP 2002005930A
- Authority
- JP
- Japan
- Prior art keywords
- saliva
- test paper
- paper
- printed
- flow rate
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、口腔内の唾液流量
の測定に使用する試験紙に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a test strip used for measuring the flow of saliva in the oral cavity.
【０００２】[0002]
【従来の技術】唾液流量の減少を伴う疾患として、ステ
ィーブン・ジョンソン症候群(Steven-Johonson syndrom
e)、シェーグレン症候群(Sjoegren's syndrome)などが
知られている。これらの疾患は、早期発見、早期治療の
ため、患者の唾液流量を測定する必要がある。2. Description of the Related Art As a disease accompanied by a decrease in saliva flow, there is Steven-Johonson syndrome (Steven-Johnson syndrome).
e), Sjoegren's syndrome and the like are known. For these diseases, it is necessary to measure a patient's saliva flow for early detection and early treatment.
【０００３】口腔唾液流量を測定する方法として、様々
な方法が知られている。例えば、カービーカップ法(Cur
by Cup Method)は、口腔の奥の頬に位置する耳下線開口
部より直接唾液を採取する方法であり、精度が最も高い
ものである。他にも、唾液の量を測定する方法として、
市販のガムを５〜１０分間噛んで唾液の量を測定するガ
ム法(Gum Method)、その他サクソン法などが知られてい
る。Various methods are known for measuring the flow rate of oral saliva. For example, the Kirby cup method (Cur
by Cup Method) is a method of collecting saliva directly from the parotid opening located on the cheek in the back of the oral cavity, and has the highest accuracy. In addition, as a method of measuring the amount of saliva,
A Gum Method for measuring the amount of saliva by chewing a commercially available gum for 5 to 10 minutes, a Saxon method, and the like are known.
【０００４】[0004]
【発明が解決しようとする課題】しかし、カービーカッ
プ法はあまり簡便でなく、ガム法、サクソン法は信頼性
が低く、問題がある。特に咀嚼時の唾液流量を測定する
ガム法などは、安静時に乾燥感がある患者は、咀嚼時に
は正常範囲に含まれる場合があるため、異常が検出され
ないことがある。さらに、唾液が極端に少ないために咀
嚼や嚥下のできない患者や、口腔機能障害のある患者に
ついては、測定が不可能である。また、唾液流量測定に
ついて、各国でそれぞれ基準が決められ、統一的な基準
はない。そこで、本発明は、簡便かつ高い精度で唾液流
量を測定することを目的とする。However, the Kirby cup method is not very simple, and the gum method and the Saxon method have low reliability and have problems. In particular, in the gum method or the like for measuring the flow rate of saliva during chewing, a patient who has a feeling of dryness at rest may be included in a normal range during chewing, so that no abnormality may be detected. Furthermore, measurement is not possible for patients who cannot chew or swallow due to extremely low saliva, or for patients with oral dysfunction. In addition, standards for saliva flow measurement are determined in each country, and there is no uniform standard. Therefore, an object of the present invention is to measure saliva flow rate simply and with high accuracy.
【０００５】[0005]
【課題を解決するための手段】上記に鑑み、本発明者ら
は、口腔内の唾液流量の測定に使用する試験紙を開発し
た。すなわち、目盛りの印刷された吸水性の細長い紙か
らなる唾液流量測定試験紙であって、前記細長い紙の一
端に水溶性の色素が印刷され、前記色素が印刷された一
端を口腔前庭においたとき、前記色素は唾液の移動に伴
って移動することを特徴とする唾液流量測定試験紙を提
供する。In view of the above, the present inventors have developed a test strip for use in measuring the flow rate of saliva in the oral cavity. That is, a saliva flow rate measurement test paper made of water-absorbing elongated paper with a scale printed thereon, wherein a water-soluble dye is printed on one end of the elongated paper, and the printed end is placed in the oral vestibule. In addition, the present invention provides a saliva flow rate measurement test paper, wherein the pigment moves with the movement of saliva.
【０００６】この唾液流量測定試験紙は、前記色素が印
刷された一端を下唇と下顎の歯槽堤の間（口腔前庭）に
挟んで一定時間おき、前記色素の移動距離を測定する。
この色素の移動距離は、唾液の量に対応するため、移動
距離を口腔内の唾液流量の指標として基準に用いること
ができるほか、適当な換算式により唾液流量を求めるこ
とができる。本発明の唾液流量測定試験紙によれば、口
腔内の唾液の量を短時間に、簡便、正確かつ高い再現性
で測定できる。[0006] The test paper for measuring saliva flow measures the movement distance of the dye at predetermined intervals with one end on which the dye is printed sandwiched between the lower lip and the alveolar ridge of the lower jaw (oral vestibule).
Since the movement distance of the pigment corresponds to the amount of saliva, the movement distance can be used as a reference as an index of the flow of saliva in the oral cavity, and the flow rate of saliva can be determined by an appropriate conversion formula. According to the test paper for measuring saliva flow rate of the present invention, the amount of saliva in the oral cavity can be measured in a short time, simply, accurately and with high reproducibility.
【０００７】本発明の唾液流量測定試験紙には、前記細
長い紙の一端に印刷された水溶性の色素を、紙の長軸方
向に対して垂直方向の直線として、又は、帯状に印刷す
ることができる。In the saliva flow rate measurement test paper of the present invention, the water-soluble dye printed on one end of the elongated paper is printed as a straight line perpendicular to the longitudinal direction of the paper or in a strip shape. Can be.
【０００８】また、本発明は、目盛りの印刷された吸水
性の細長い紙からなる唾液流量測定試験紙であって、唾
液に反応することによって変色する試薬が前記細長い紙
に含まれていることを特徴とする唾液流量測定試験紙を
提供する。この測定試験紙は、口腔前庭に挟んで一定時
間おいた後、試験紙に染み込んだ唾液によって変色した
試験紙の部分の長さを測定する。この変色した部分の長
さは、口腔内の唾液流量と対応するため、この長さを口
腔内の唾液流量の指標として基準に用いることができる
ほか、適当な換算式により唾液流量を求めることができ
る。唾液によって変色する試薬としては、唾液中の各種
の成分、例えば水分などで変色するものを使用すること
ができる。The present invention also relates to a test paper for measuring saliva flow rate, which is made of a water-absorbing, elongated paper having a scale printed thereon, wherein the reagent, which changes color when reacted with saliva, is contained in the elongated paper. Provided is a saliva flow rate test strip characterized by the following. This measurement test paper is placed in the oral vestibule for a certain period of time, and then the length of the portion of the test paper discolored by saliva soaked in the test paper is measured. Since the length of the discolored portion corresponds to the saliva flow rate in the oral cavity, this length can be used as a reference as an index of the saliva flow rate in the oral cavity, and the saliva flow rate can be obtained by an appropriate conversion formula. it can. As a reagent that changes color with saliva, various components in saliva, for example, a reagent that changes color with moisture or the like can be used.
【０００９】本発明の唾液流量測定試験紙の紙の素材と
しては、ワットマン紙を使用することができる。As the paper material of the test paper for measuring saliva flow rate according to the present invention, Whatman paper can be used.
【００１０】[0010]
【発明の実施の形態】以下に図を参照しながら、本発明
の唾液流量測定試験紙を説明する。図１（Ａ）に示すよ
うに、本発明の唾液流量測定試験紙１は、目盛り２の付
いた細長い紙からなる。試験紙１の一端には色素３が印
刷されている。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The test paper for measuring saliva flow rate according to the present invention will be described below with reference to the drawings. As shown in FIG. 1 (A), the test paper 1 for measuring saliva flow rate of the present invention is made of an elongated paper with a scale 2. The dye 3 is printed on one end of the test paper 1.
【００１１】試験紙１の大きさは、例えば、５ｍｍ×４
０ｍｍ、５ｍｍ×５０ｍｍなど適宜に変更可能である。
例えば、試験時間を長く取る場合や、被験者の唾液の量
が多いことが予測される場合は、より長い形状の試験
紙、例えば長さを５０ｍｍ以上とするのが望ましい。一
方、試験時間を短くする場合や、被験者の唾液の量が少
ないことが予測される場合は、短い形状の試験紙とする
ことができる。The size of the test paper 1 is, for example, 5 mm × 4
It can be changed as appropriate such as 0 mm, 5 mm × 50 mm.
For example, when a long test time is required or when the amount of saliva of the subject is expected to be large, it is desirable that the test paper having a longer shape, for example, the length be 50 mm or more. On the other hand, when the test time is shortened or when the amount of saliva of the subject is expected to be small, a test paper having a short shape can be used.
【００１２】試験紙１は、細長い形状であれば良く、色
素３の印刷されている側の端部の角を丸くすることもで
きる。図１（Ａ）に示すほぼ長方形以外の形状では、図
１（Ｂ）に示すように、細長いＴ字型にして、色素の印
刷されている側の端部を口にくわえたときの安定性を高
めることができる。The test paper 1 may have an elongated shape, and the corner of the end on which the dye 3 is printed may be rounded. In the shape other than the substantially rectangular shape shown in FIG. 1 (A), as shown in FIG. 1 (B), it is formed into an elongated T-shape, and the stability when the end on the side where the dye is printed is held in the mouth. Can be increased.
【００１３】試験紙の材質は、口内においても破けるこ
とがない程度の耐水性を有する、吸水性の紙であれば特
に限定されない。このような紙の例として、市販の濾紙
が挙げられ、例えば４１番のワットマン紙が挙げられる
が、上記のような耐水性、吸水性を有する紙であれば特
に限定されない。[0013] The material of the test paper is not particularly limited as long as it is a water-absorbing paper having a water resistance such that it does not break even in the mouth. Examples of such papers include commercially available filter papers, such as No. 41 Whatman paper, but are not particularly limited as long as they have the above-described water resistance and water absorbency.
【００１４】色素３は、試験紙１の端部の縁の部分に印
刷することができる。あるいは、図２（Ａ）及び（Ｂ）
に示すように、縁から離れた箇所、例えば、５ｍｍ〜１
５ｍｍ離れた位置に印刷されるが、この色素３の位置は
特に限定されない。この色素は、試験紙に染み込んで移
動する唾液と共に移動するため、唾液の移動の目安とな
る。このような色素３としては、人体に毒性がなく、水
溶性でかつ唾液ともに試験紙上を移動するものであれ
ば、特に限定されない。色素の色は、紙と識別できる色
であればよく、青、黒、赤などの目立つ色が好ましい。
このような色素３は、紙の長軸方向に対して垂直方向の
直線又は帯状の印刷とすることができるが、直線又は帯
状のもののみに限定することなく、ほぼ円形のスポット
にするなど各種の変更が可能である。色素３は、試験紙
１の表面のみ又は両面に印刷される。The dye 3 can be printed on the edge portion of the test paper 1. Alternatively, FIGS. 2A and 2B
As shown in FIG.
It is printed at a position 5 mm away, but the position of the dye 3 is not particularly limited. Since this dye moves together with the saliva which permeates the test paper and moves, it serves as a measure of the movement of the saliva. Such a dye 3 is not particularly limited as long as it has no toxicity to the human body, is water-soluble, and moves both with saliva on the test paper. The color of the pigment may be any color that can be distinguished from paper, and is preferably a conspicuous color such as blue, black, or red.
Such a dye 3 can be printed in a straight line or a band shape in a direction perpendicular to the long axis direction of the paper, but is not limited to a straight line or a band shape. Can be changed. The dye 3 is printed only on the surface of the test paper 1 or on both sides.
【００１５】試験紙１の目盛り２は、試験紙の長軸方向
に沿って印刷される。好ましくは、１ｍｍごとに印刷さ
れ、唾液の移動を示す端部からの距離を示す数値が、例
えば５ｍｍごとに付けられる。この目盛りの印刷に用い
られるインクは、実質的に水に不溶性なものが好まし
い。目盛り２の印刷の色は、水溶性の色素３と異なる色
が望ましいが、試験紙と識別可能な任意の色であればよ
く、単色で印刷されても、多色で印刷されてもよい。The scale 2 of the test paper 1 is printed along the longitudinal direction of the test paper. Preferably, it is printed every 1 mm, and a numerical value indicating the distance from the end indicating the movement of saliva is attached, for example, every 5 mm. The ink used for printing the scale is preferably substantially insoluble in water. The printing color of the scale 2 is desirably different from that of the water-soluble dye 3, but may be any color that can be distinguished from the test paper, and may be printed in a single color or in multiple colors.
【００１６】本発明の唾液流量測定試験紙は、使用する
まで無菌的に保存され、例えば紫外線照射により、無菌
的にパックに包んだ状態で保存される。本発明の唾液流
量測定試験紙を用いた唾液流量の測定は、次のような手
順で行われる。The test paper for measuring the flow rate of saliva of the present invention is stored aseptically until it is used, and is stored aseptically in a pack, for example, by irradiation with ultraviolet rays. The measurement of saliva flow rate using the test paper for measuring saliva flow rate of the present invention is performed in the following procedure.
【００１７】図３（Ａ）にあるように、下唇５を引っ張
って、下唇５と下顎の歯槽堤６との間に水溶性の色素が
印刷された側の端部を下顎の歯槽堤６に当てるようにし
て、口腔前庭部に試験紙１をおいて、下唇５と歯槽堤６
の間に唾液流量測定試験紙を挟む。試験紙１を挟んだ状
態で口を軽く閉じ、図３（Ｂ）に示すような状態で保持
する。唾液は、色素が印刷された側の端部から試験紙１
に染み込み、試験紙１の長軸方向に沿って移動してい
く。唾液の移動に伴って、唾液中の水分により溶けだし
た色素３が試験紙１の長軸方向に沿って移動していく。
適当な時間経過後、取り出し、試験紙１の長軸に沿って
移動した色素の移動距離を測定する。As shown in FIG. 3A, the lower lip 5 is pulled, and the end on the side where the water-soluble pigment is printed between the lower lip 5 and the lower alveolar ridge 6 is connected to the lower alveolar ridge. 6 and put the test strip 1 in the vestibule of the oral cavity, and the lower lip 5 and the alveolar ridge 6
Insert a saliva flow measurement test paper between them. The mouth is lightly closed with the test paper 1 sandwiched therebetween, and is held in a state as shown in FIG. Saliva was applied to the test paper 1 from the end where the dye was printed.
And moves along the long axis direction of the test paper 1. As the saliva moves, the dye 3 dissolved by the water in the saliva moves along the long axis direction of the test paper 1.
After an appropriate time has elapsed, the sample is taken out and the distance of the dye moved along the long axis of the test paper 1 is measured.
【００１８】適当な時間経過後の試験紙を図４に示す。
図４は、図２（Ａ）に示した試験紙を使用したものであ
る。移動した色素のフロント部分７を目安として、紙に
印刷された目盛り２で計測する。この移動距離は、唾液
の量に対応するため、唾液流量が多いときは移動距離が
大きく、唾液流量が少ない場合は移動距離が小さい。FIG. 4 shows the test paper after an appropriate time has elapsed.
FIG. 4 uses the test paper shown in FIG. 2 (A). The measurement is performed on the scale 2 printed on paper, using the front part 7 of the dye that has moved as a guide. Since this movement distance corresponds to the amount of saliva, the movement distance is large when the flow rate of saliva is large, and is small when the flow rate of saliva is small.
【００１９】口腔前庭部に挟む時間は、紙の長さ、被験
者の予測される唾液流量により適宜変更して行うことも
可能であるが、唾液流量測定の基準として使用する場合
は、統一した紙の長さの試験紙を使用して、口腔前庭部
に挟む時間を統一して行う。この時間は、例えば、５×
４０ｍｍの試験紙を用いて行う場合は３〜７分の間から
一定の時間を選択できるが、好ましくは約５分間であ
る。この一定の時間にわたって、試験紙を口腔前庭部に
挟んだ後、色素の移動距離を計測する。The time between the oral cavity and the vestibule can be changed appropriately according to the length of the paper and the expected saliva flow rate of the subject. Using a test paper of length, the time between the oral vestibules is unified. This time is, for example, 5 ×
When using a test paper of 40 mm, a certain time can be selected from 3 to 7 minutes, but preferably about 5 minutes. After the test paper is sandwiched between the oral vestibules over this fixed time, the distance traveled by the dye is measured.
【００２０】このように水溶性の色素を端部に印刷した
試験紙の変形例として、唾液に反応することによって変
色する試薬が、前記細長い紙に含まれている試験紙を用
いることができる。この試験紙は、唾液中の各種の成
分、例えば水分や唾液アミラーゼなどで変色する試薬を
含むため、試験紙にどこまで唾液が染み込んだかが視覚
的に分かるようになっている。試験紙の変色した部分の
長さは、口腔内の唾液流量と対応するため、この長さを
測定することにより、唾液流量を測定することができ
る。As a modified example of the test paper in which the water-soluble dye is printed on the end as described above, a test paper in which the reagent that changes color by reacting with saliva is contained in the elongated paper can be used. Since this test paper contains various components in saliva, for example, a reagent that changes its color due to moisture, salivary amylase, etc., it is possible to visually determine how much saliva has permeated the test paper. Since the length of the discolored part of the test paper corresponds to the saliva flow rate in the oral cavity, the saliva flow rate can be measured by measuring this length.
【００２１】[0021]
【実施例】以下に実施例を挙げて、本発明をさらに詳細
に説明するが、これらにより本発明を制限するものでは
ない。唾液流量の減少するスティーブン・ジョンソン症
候群の患者１名、シェーグレン症候群の患者６名、シェ
ーグレン症候群によるものではないドライアイ患者１４
名、健常者３９名を対象に、本発明の唾液流量測定試験
紙を用いて測定した。測定は５×４０ｍｍの試験紙を用
いて行い、５分間の移動距離を計測することにより行っ
た。結果を表１に示す。EXAMPLES The present invention will be described in more detail with reference to the following Examples, but it should not be construed that the present invention is limited thereto. 1 patient with Steven-Johnson syndrome with reduced salivary flow, 6 patients with Sjogren's syndrome, 14 dry eye patients not due to Sjogren's syndrome
And 39 healthy persons were measured using the saliva flow rate test paper of the present invention. The measurement was performed using a test paper of 5 × 40 mm, and the measurement was performed by measuring a moving distance for 5 minutes. Table 1 shows the results.
【００２２】[0022]
【表１】 [Table 1]
【００２３】同じ患者に対して、高い精度で唾液流量を
測定できるとされているカービーカップ法により唾液流
量を測定した。結果を表２に示す。The salivary flow rate of the same patient was measured by the Kirby cup method, which can measure the salivary flow rate with high accuracy. Table 2 shows the results.
【００２４】[0024]
【表２】 [Table 2]
【００２５】表１と表２の結果から、唾液流量の少ない
被験者は、色素の移動距離が小さく、唾液流量が正常と
思われる被験者は、色素の移動距離が大きいことが分か
る。従って、色素の移動距離は、口腔内の唾液流量の指
標として使用できることが分かる。From the results shown in Tables 1 and 2, it can be seen that subjects with a small flow rate of saliva have a small distance of movement of the dye, and subjects with a normal flow rate of the saliva have a long distance of movement of the dye. Therefore, it can be seen that the moving distance of the pigment can be used as an index of the saliva flow rate in the oral cavity.
【００２６】上記の結果と、信頼性が低いとされている
ガム法により測定した結果とから、本発明の唾液流量測
定試験紙を用いた方法、カービーカップ法及びガム法で
得られる結果の相関を表３に示す。なお、表中のかっこ
内の数値は、被検者数である。From the above results and the results measured by the gum method which is considered to be unreliable, the correlation between the results obtained by the method using the test paper for measuring saliva flow rate of the present invention, the Kirby cup method and the gum method Are shown in Table 3. The numbers in parentheses in the table are the number of subjects.
【００２７】[0027]
【表３】 [Table 3]
【００２８】表３から明らかなように、本発明の唾液流
量測定試験紙を用いて得られる結果は、信頼度が低いと
されているガム法とは相関関係が低いが、信頼性が高い
とされているカービーカップ法と強い相関関係を示す。
従って、本発明の試験紙により得られる結果は、口腔内
の唾液流量の測定値として信頼性が高いことが分かる。As is evident from Table 3, the results obtained using the test paper for measuring saliva flow rate of the present invention have a low correlation with the gum method which is considered to have low reliability, but have a high reliability. It shows a strong correlation with the Kirby cup method used.
Therefore, it can be seen that the results obtained with the test paper of the present invention are highly reliable as measured values of the saliva flow rate in the oral cavity.
【発明の効果】本発明によれば、短時間で精度の高い口
腔内の唾液流量を測定することのできる測定紙が提供さ
れる。この唾液流量測定試験紙は、被験者に苦痛を与え
ることもない上、再現性が高く、測定に要する費用が安
いため、様々な唾液減少を伴う疾患の統一的な診断基準
として用いることが可能である。さらに、安静時の唾液
流量が測定できるため、咀嚼時の唾液流量を測定する方
法であるガム法等では評価できない安静時に乾燥感のあ
る患者、唾液の特に少ない患者、及び口腔機能障害のあ
る患者についても適正に評価が可能である。According to the present invention, there is provided a measuring paper which can measure the flow rate of saliva in the oral cavity in a short time and with high accuracy. The test paper for measuring saliva flow does not cause any pain to the subject, it is highly reproducible, and the cost required for the measurement is low, so that it can be used as a unified diagnostic standard for various diseases accompanied by salivary loss. is there. Furthermore, since the saliva flow rate at rest can be measured, patients with dryness at rest, patients with particularly low saliva, and patients with oral dysfunction that cannot be evaluated by the gum method, which is a method of measuring saliva flow during chewing, can be evaluated. Can be evaluated appropriately.
【図１】本発明の唾液流量測定試験紙を示す図である。FIG. 1 is a view showing a test paper for measuring saliva flow rate according to the present invention.
【図２】本発明の唾液流量測定試験紙を示す図である。FIG. 2 is a diagram showing a saliva flow rate measurement test paper of the present invention.
【図３】本発明の使用方法を示す図である。FIG. 3 is a diagram showing a method of using the present invention.
【図４】使用後の本発明の唾液流量測定試験紙を示す図
である。FIG. 4 is a view showing a test paper for measuring saliva flow rate of the present invention after use.
１ 唾液流量計測試験紙 ２ 目盛り ３ 色素 ５ 下唇 ６ 歯槽堤 ７ 移動した色素のフロント部分 1 Saliva flow rate measurement test paper 2 Scale 3 Dye 5 Lower lip 6 Alveolar ridge 7 Front part of moved dye
───────────────────────────────────────────────────── フロントページの続き (72)発明者 小関 真理子 千葉県船橋市宮本９丁目11番１号 グリン パーク301 Ｆターム(参考） 2G045 AA25 CB07 FA11 FA18 FB17 HA10 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Mariko Koseki 9-11-1, Miyamoto, Funabashi-shi, Chiba Green Park 301 F-term (Reference) 2G045 AA25 CB07 FA11 FA18 FB17 HA10
Claims (5)
らなる唾液流量測定試験紙であって、前記細長い紙の一
端に水溶性の色素が印刷され、前記色素が印刷された一
端を口腔前庭においたとき、前記色素は唾液の移動に伴
って移動することを特徴とする唾液流量測定試験紙。1. A saliva flow measurement test paper comprising a water-absorbing elongated paper on which a scale is printed, wherein one end of the elongated paper is printed with a water-soluble dye, and one end on which the dye is printed is connected to an oral vestibule. The saliva flow rate measurement test paper characterized in that the dye moves with the movement of the saliva when it is scented.
の色素が、紙の長軸方向に対して垂直方向の直線として
印刷されることを特徴とする請求項１に記載の唾液流量
測定試験紙。2. The saliva flow measurement according to claim 1, wherein the water-soluble dye printed on one end of the elongated paper is printed as a straight line perpendicular to the longitudinal direction of the paper. Test paper.
の色素が、帯状に印刷されることを特徴とする請求項１
に記載の唾液流量測定試験紙。3. The water-soluble dye printed on one end of the elongated paper is printed in a strip shape.
A test paper for measuring saliva flow according to the above.
らなる唾液流量測定試験紙であって、唾液に反応するこ
とによって変色する試薬が前記細長い紙に含まれている
ことを特徴とする唾液流量測定試験紙。4. A saliva flow rate measurement test strip made of water-absorbing, elongated paper on which a scale is printed, wherein said reagent contains a reagent that changes color by reacting with saliva. Flow measurement test paper.
ずれか一に記載の唾液流量測定試験紙。5. The test paper for measuring salivary flow according to claim 1, wherein the test paper is made of Whatman paper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000181142A JP2002005930A (en) | 2000-06-16 | 2000-06-16 | Saliva flow measuring test paper |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000181142A JP2002005930A (en) | 2000-06-16 | 2000-06-16 | Saliva flow measuring test paper |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002005930A true JP2002005930A (en) | 2002-01-09 |
Family
ID=18682120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000181142A Pending JP2002005930A (en) | 2000-06-16 | 2000-06-16 | Saliva flow measuring test paper |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2002005930A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005004422A1 (en) * | 2003-06-30 | 2005-01-13 | Net Agent, Co., Ltd. | Electronic mail transmission/reception system |
| JP2007271535A (en) * | 2006-03-31 | 2007-10-18 | Gc Corp | Saliva examination tool |
| FR2912894A1 (en) | 2007-02-22 | 2008-08-29 | Carilene Lab | Saliva quantity determining device for detecting symptom of xerostomia, has pellet or circular shaped compressed sponge dilated during contact of saliva, and longilineal portion connecting compressed sponge to gripping units |
-
2000
- 2000-06-16 JP JP2000181142A patent/JP2002005930A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005004422A1 (en) * | 2003-06-30 | 2005-01-13 | Net Agent, Co., Ltd. | Electronic mail transmission/reception system |
| JP2007271535A (en) * | 2006-03-31 | 2007-10-18 | Gc Corp | Saliva examination tool |
| FR2912894A1 (en) | 2007-02-22 | 2008-08-29 | Carilene Lab | Saliva quantity determining device for detecting symptom of xerostomia, has pellet or circular shaped compressed sponge dilated during contact of saliva, and longilineal portion connecting compressed sponge to gripping units |
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