JP2001526946A - Radioactive gas injection device - Google Patents

Abstract

(57) Abstract: An apparatus for filling a catheter device with a radiation carrier material is provided. SOLUTION: In a radioactive gas injection device 1400 for sending radioactive gas from a radioactive glass bottle 1401 to an external device 1422, an enclosure 1403 accommodating the radioactive glass bottle 1401 and an access to the radioactive glass bottle 1401 from the enclosing body 1403. A gas-tight variable volume chamber 1411, 1452 for containing the radioactive gas, which selectively communicates with the first passage 1406, and a gas-tight variable volume chamber 1411 containing the radioactive gas. And a selection mechanism 1409 for selectively conducting the device 1422.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD OF THE INVENTION

The present invention relates to medical devices, and in particular, to devices used in delivering radiation therapy to a patient.

[0002]

[Prior art]

Angioplastic surgery is an established surgical method for reducing the effects of narrowing the walls of arteries in a patient's vasculature and the effects of atherosclerotic plaque adhering to the walls. Such effects are reduced with the use of a catheter inserted into the site of the blood vessel that is clogged with disease. The balloon part of the catheter,
Inflation to a predetermined pressure range and magnitude compresses the plaque occlusion, thereby increasing the inner diameter of the previously clogged and narrowed artery. Thereafter, the balloon is deflated and the catheter is removed.

[0003] After angioplasty surgery is performed, as many as one-third to one-half of the patients immediately develop restenosis. Such restenosis occurs after angioplasty surgery or other recannulation procedures, with or without stenting, and in restenosis, benign cell transplantation and proliferation can result in restenosis. Lesions are formed, resulting in a further occlusion of intravascular structures.

[0004] Radiation therapy is administered to a patient and radiation is managed for various reasons, for example, to treat a malignant or benign tumor that causes restenosis. Such treatment methods are disclosed in U.S. Pat. Nos. 5,059,166; 5,213,561;
No. 2168.

[0005] A radiotherapy system needs to: (A) Applying a predetermined total dose and a uniform dose to the lesion at a predetermined penetration depth while minimizing exposure of surrounding healthy tissue to radiation. (B) The surgeon or nurse can be protected while managing the radiation treatment without risk. (C) Use radiological materials that are readily and inexpensively available from commercial vendors. (D) Maintenance of special equipment or minimization of radiotherapy equipment other than the usual equipment used in many nuclear medicine or radiation oncology operations. (E) using a radiation carrier material having inert gas-gas properties when applied in the form of an unsealed free gas, wherein molecules of the carrier material are rapidly lost through the patient's body; A rapid dilution that is possible and without prolonged accumulation in organs or chemical interactions, and that allows rapid release of radioactive material from blood vessels through the lungs. (F) Minimize prolonged cessation of normal blood flow during surgery, thereby giving more freedom in management time and dose. (G) Use of a stable radiation carrier material that can be compressed and accumulated to a high millicuule activity per cm3 with reasonable cost and convenience. (H) Beta particles that allow good initial dose rate distribution and energy transfer within the first 1 mm directly adjacent to the target tissue and do not penetrate further than this depth to use. (I) For the first 1 mm, use gamma photon energy with a depth of dose that can be provided with a dose of beta to compensate for the dose and supplement the target tissue with an additional 2, For 3 mm, an additional dose is mainly given. (J) Utilizing beneficial physical and biological radiation properties for restenosis and malignant tumors or internal lesions that need to be directly radiated to other tissues. (K) Distributing an effective radiation dose to several hundred micrometers or more of the target tissue while attenuating the transmitted dose and increasing the side effect radiation for blood circulating in the device.

[0006]

SUMMARY OF THE INVENTION In order to achieve the above object, a predetermined dose of radiation fluid is supplied to a treatment apparatus from a storage of radiation material, and then the fluid is supplied to the radiation device after the treatment is completed. It would be desirable to have a device that provides a curable dose of radiation fluid that has means for returning it to the reservoir. Current systems for dispensing radioactive gas are primarily designed for pulmonary inhalation, but once introduced into the patient, the gas cannot be recovered. A variety of syringe-shaped devices are known for distributing gas and inflating balloon catheters, but they prevent leaks that protect patients and stakeholders, and It lacks the safety required to work with tilting radioactive gases. Furthermore, there is a need for a system that can load a commercially available radioactive source vial with a pre-calibrated radiation dose into a direct injection device.

[0007]

[Means for Solving the Problems]

The present invention is the balloon catheter for medical radiation treatment of the present invention, which can provide radiation to a treatment site. In particular, the device of the present invention has a balloon-like portion that emits radiation from a radioactive fluid, such as a xenon isotope. The balloon has a radiation dosimeter that measures the radiation dose rate, which is adjusted by the surgeon or medical personnel to provide the patient with a predetermined radiation dose. The dosimeter's modulus is indicated by the manufacturer and is fixedly mounted on the dispensing device, such as the dosimeter's indicator.

In one embodiment of the injection means, the device of the invention comprises a valve having a plurality of positions, whereby the operator interconnects the vial for storage and the syringe and places the syringe in the gas. And switch the valve so that the syringe is in communication with the catheter for radiation distribution, then return to the original position to draw the gas back into the syringe and return the gas back to the original storage vial. return. By switching this valve to the third position, the gas remaining in the passage and the valve can be removed via an external vacuum line. The position of the fourth valve stops conduction between the aforementioned components.

In another embodiment of the injection means, a separately fluid-filled syringe is used,
Put the radioactive gas into the syringe. The position of this valve is switched so that the syringe is in communication with the dispensing catheter. The fluid in the storage vial is drawn back into a separate syringe, and once the gas is drawn back into the main syringe,
It is returned in the storage vial.

In yet another embodiment of the injection means, a syringe filled with fluid exerts pressure on the vial chamber, pushing the vial down and piercing the vial.

[0011] In yet another embodiment of the injection means, the enclosure chamber of the present invention is transferred from the storage vial, containing a storage vial and a multi-way valve, acting as a plunger. Compress the volume of a chamber formed in the main housing of the device that holds the gas.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION

FIG. 1 shows a partial cross-sectional top view of a medical radiation distribution device 1400 of the present invention. The radiation distribution device 1400 includes a vial enclosure for radioactive gas, such as a vial housing 1403 for a radiation source, a selection mechanism, such as a multi-way valve 1409, and a gas-tight, variable volume, such as a gas-tight syringe 1411. Chambers, which include passages, lines, connectors, ports or cannulas 1406, 1408.
, 1412, 1413, 1415, 1417-1421, and 1424 are connected to the radiation distribution balun catheter 1422. Commercially available fluid pressure gauge 14
14 is located between cannulae 1415 and 1417 using a known connector 1418. Multi-way valve 1409 is preferably a four-way valve, with connectors 1408 and 1420, cannula 1415, and vacuum line connector 1
424 are interconnected. The valve 1409 has a selector knob 1421 and selectively connects the main cannula 1415 to the vial connector 1408, catheter connector 1420, and vacuum line connector 1424.

The dispensing device 1400 has a valve gauge housing 1427 and houses a pressure gauge, a four-way valve, and connectors, ports, and cannulas in a chamber 1428. As a safety mechanism, an attached evacuation line 1425 is attached to the second evacuation line 1426 to evacuate the radiation fluid from inside the chamber 1428.
The main evacuation line 1423 is connected to the four-way valve 1409 and the valve 140
Vacuum the radiant fluid through 9. To enhance safety for the operator and the patient, the outer housing material of the dispensing device comprises at least one of barium, tungsten, lead, tantalum, titanium, bismuth, gold, platinum, palladium, rhodium, or other suitable material. Includes high-density materials, which shield beta and gamma particles emitted from the radioactive source material. The shielding material may be incorporated into a plastic housing or may include a vial for a source of radiation, or a line containing a dispensing syringe, or a chamber.

The dispensing device 1400 further includes a vial chamber enclosure for the radiation source, such as a housing 1403 attached to the valve gauge housing 1427. The glass bottle 14 for the radiation source is contained in the glass bottle chamber 1403 for the radiation source.
A vial chamber 1402 for the radiation source for placing the 04 is included. Radiation source vial enclosure 1403 has enclosure means 1404, which serves to mount the vial in the chamber and seal enclosure 1403 to prevent gas leakage. From the vial connector 1408, the known penetration cannula 1
406 extends and enters chamber 1402. The glass bottle for radiation source 1401 is
It is located in the chamber 1402. The source glass bottle 1401 contains a radiation fluid, for example, Xenon 133 gas, and distributes radiation to an external device 1422, such as a balun distribution catheter 1422.

The source glass vial 1401 is inserted into the chamber 1402, is directed toward the penetrating cannula 1404 via a biasing mechanism 1442, such as a threaded chamber cap 1482, toward 1406, and 1482
Has an enclosure 1404 for the vial enclosure and holds a gas tight seal to the chamber 1402. In this embodiment, the threaded chamber cap 14
A biasing mechanism 1442, such as 04, is screwed into the chamber. The inner surface of the biasing mechanism 1442 is biased forward to contact the vial 1401 and contact the fixed penetrating cannula 1404. Penetrating cannula 140
6 extends through the glass bottle partition 1407 of the glass bottle 1401 for the radiation source,
Establish the flow of the radiation fluid contained therein. Glass bottle bulkhead 140 for radiation source
7 is urged toward one end of the vial chamber 1402 and engages the O-ring 1405 to maintain a glass-tight seal. If radioactive fluid leaks from the vial 1404 and enters the chamber 1402, a second evacuation line 1425 attached to the second vacuum port 1426 is provided by a conducting channel 1429 extending between the chambers 1402 and 1428. Remove.

The dispensing device 1440 has a syringe housing 1416 connected to a valve gauge housing 1427. The gas tight syringe 1411 is connected to the syringe housing 1
Located within 416, connected to the syringe and applying pressure to gauge cannula 1417. The conduction channel 1430 communicates with the air spaces 1432 and 1436,
The radioactive gas or fluid leaking from the syringe 1414 is withdrawn. Second syringe communication channel 1431 connects to air spaces 1432 and 1436. The syringe housing 1416 is enclosed at one end with a threaded collar 1411 through which a commercially available, threaded advancement mechanism 1438, known in the art, is inserted into the handle 143.
9 and the screw release mechanism 1440. Opening 143 around advance mechanism 1438
By 7, air is drawn into the syringe housing and vacuums the leaked radioactive fluid. At the other end of the housing is a syringe barrel 1434, in which a syringe plunger 1433 is located. A known O-ring 1435 is located at the root of the plunger 1433 to maintain a gas tight seal.

[0017] A syringe plunger 1433 is used to evacuate fluid, such as air or radiant fluid, from the dispensing catheter when the multi-way valve 1409 is in place. Using a gas tight syringe 1411 and plunger 1433,
By properly positioning the multi-way valve, air or radiant fluid is drawn or returned to the vial 1401 for gas-radiating fluid radiation source and to the vacuum line 1425 or the dispensing catheter 1422.

The primary method of the therapeutic radiation distribution device 1400 is to place a source vial 1401 in a source vial chamber 1402 and then seal it. A radiation source glass bottle 1401 is biased by a biasing mechanism, for example, a screw cap 1482.
Is advanced until the septum 1407 of the vial 1401 is pierced by the needle piercing cannula 1406 attached to the multi-way valve 1409. This step is performed by a technician or nurse before bringing the device 1400 to the actual treatment location. Prior to performing the treatment, the device 1400 is connected to the balloon catheter 14.
Attach to a radiation distribution device such as 22. Equipment vacuum line port 14
24, 1426 are connected to the exhaust system. The treatment is catheter 142
2, the catheter passage 1419 is selected and the plunger 1433 of the syringe 1411 is withdrawn and the balloon catheter 142 attached to the device
From 2, start by drawing air. Then, the multi-way valve 1409 is
Switching to the main evacuation line 1423, the air from the syringe 1411 is discharged to a commercially available radioactive gas exhaust device. A multi-way valve 1409 is attached to the passage 1406 and the vial 1401 for the radiant fluid radiation source, and the syringe 1411 is filled with radioactive gas.

To treat a patient, a multi-way valve 1409 is attached to the catheter passage 1419, the syringe plunger 1433 is advanced using a threaded advance mechanism 1438, and radioactive gas is transferred from the syringe 1411 to the catheter 1422. Proceed until the transition is complete. After irradiation, the radioactive fluid is drawn into syringe 1411. The multi-way valve 1409 includes the passage 1406 and the glass bottle 1 for the radioactive radiation source.
The gas is directed to 401 and returned to the glass vial for the radiation source. Multi-way valve 140
9 is switched to a vacuum line 1423 to draw some of the remaining gas in the system.

FIG. 2 is a partial cross-sectional front view of the injection device 1400 of FIG. The figure shown here shows the interconnection between a multi-way valve 1409 and a pressure gauge 1414, which is attached to a syringe port 1412 mounted below the multi-way valve 1409, a valve cannula 1415 Is performed through a gauge for the connector 1413. Primary and secondary vacuum line connectors 1424 and 1426 are shown for multi-way valve 1409 and valve pressure gauge chamber 1428.

FIG. 3 is a partial cross-sectional side view of a second embodiment of the injection device 1400 of the present invention. The device has a system for drawing a radioactive fluid, such as xenon 133 gas, from a glass vial 1401 for the source of radioactive radiation, which draws the fluid into a pressurized gas syringe 1411 and then to a delivery catheter 1422. This is done by injecting into such an external device. For safety reasons, the device is attached to a known exhaust system to evacuate any radioactive fluid remaining in the device after treatment or leaking from connections or seals. The components of the radioactive fluid injection device are housed within the outer housing 1452 to protect the user from radiation.

The glass bottle 1401 for a radiation fluid radiation source is a glass bottle enclosure 140 for a radioactive gas.
The threaded vial chamber cap 1482 is removed and the radiant fluid radiation source vial 1401 is placed in the radiation source vial chamber 1402 to mount it on the apparatus. Plunger 1444 is slidably mounted on a cap that houses the bottom of the source vial when the vial is placed in the chamber. Plunger shaft 1456
The upper lock handle 1443, shown in cross-section in FIG. 4, is rotated about the shaft 1456 to a position that allows the plunger to be advanced using the external handle 1446. Radiation source vial 1401 is advanced within radiation source vial chamber 1402 and penetration cannula 1406 is inserted into vial septum 1.
It is advanced until it passes through 407. Penetration cannula 1406 supplies radioactive gas from radiation source vial 1401 to an external device such as balloon catheter 1422. A spring 1445 mounted around the plunger shaft 1456 imparts a pull on the vial 1401 for the radiation source and places the vial in that position. Another embodiment of a penetrating cannula 1406 is shown in FIG. In this embodiment, the penetrating cannula 1406 is protected by a plastic sheath 1462 that is held by an attached spring 1449 that compresses with the advancing source vial 1401 and a sheath 1462. To force the cannula tip through the septum of the vial.

Returning to FIG. 3, the leak of radioactive fluid between the penetration cannula 1406 and the septum 1407 is withdrawn from the source vial chamber 1402 via a vacuum port 1450 attached to a standard radioactive gas exhaust system. After the radiation source vial 1401 is pierced by the penetrating cannula 1406, after the multi-directional valve, the multi-directional valve 1409 is replaced with the radiation source vial 1401 by the syringe 141.
It is positioned so as to communicate with a gas-tight variable volume chamber such as 1. The radioactive fluid in the glass bottle 1401 for the radiation source is
When pulled out with the outer handle 1439, it enters the gas injector 1411. The double seal on the head 1472 of the plunger 1433 prevents fluid from leaking into the air space 1436 between the plunger and the syringe housing 1416. Fluid leaking into the air space 1436 is
Via 51, it enters a standard radioactive gas exhaust system. In this embodiment, the syringe chamber housing 1416 is enclosed using an enclosure seal mechanism 1447, for example, a threaded cap. O-ring 1448 provides a seal between syringe chamber housing 1416 and threaded cap 1447.

When a radioactive fluid is introduced into a gas-tight syringe 1411, the multi-way valve 14
09 is directed to a passageway or location of a cannula 1419 to allow communication between the gas tight syringe 1411 and the radioactive fluid dispensing catheter 1422. A connector 1421 is located at the tip 1490 of the infusion device 1400, and the dispensing catheter 1422 is attached to the device 1400. In this embodiment, a threaded coupler 1475 is attached to a threaded connector 1421.
After being attached to a conducting channel and a vacuum channel 1473 leading to an outgoing evacuation line 1432, an air space 1474 is formed at the coupling site. The treatment is performed by releasing the radioactive fluid in the syringe 1141 into the dispensing catheter 1422 for a predetermined period to expose the target site to radiation for treatment. During the dispensing of the radioactive fluid, the pressure gauge
Monitor the pressure of the fluid exiting zero. After a predetermined period, the syringe plunger 14
33 is withdrawn and the radioactive fluid is returned to the syringe 1411. Multi-directional valve 14
09 is then returned to the sole vial position and the radioactive fluid is returned into the original source glass bottle 1401. The final step is to disconnect the source glass vial 1401 and the penetrating cannula 1406 and evacuate any radioactive fluid remaining in the system.

FIG. 6 is a cross-sectional view of a third embodiment of an injection device 1400,
It has a second syringe 1457 for applying pressure to and replacing the radioactive fluid from the radiation source glass bottle 1401. A selection mechanism, such as a multi-way valve 1409, comprises a gas-tight, variable volume chamber, such as a first syringe 1411;
1 is provided so as to conduct through a cannula 1404. A second syringe 1457, containing an inert fluid, is provided within the vial for radiation source.
It is emitted into an emission radiation source vial 1401 through an inlet cannula 1454 that has passed through a partition 1407 of 401. Inert gas fills the space 1455 in the vial for the radiation source, displacing the radioactive fluid, and this fluid is forced into the first syringe 1411 via the outlet cannula 1406 for the outlet. . The multi-way valve 1409 includes a first syringe 1411 and a distribution catheter 142
The two are selected to conduct and the first syringe 1411 is used for treatment. After the gas is drawn back into the first syringe 1411, the multi-way valve 1409 is switched back to allow communication between the first syringe 1411 and the vial 1401 for the radiation source, and The gas remaining in the glass bottle 1401 is returned.

FIG. 7 is a cross-sectional view of a fourth embodiment of an injection device 1400 that has a second syringe 1457 and is located in a vial enclosure chamber space 1402 at one end of a vial 1401 for a radiation source. Apply pressure to advance the vial into the enclosure chamber and cause the cannula to penetrate the vial septum 1407. This gas is drawn into a gas tight, variable volume chamber, such as a first syringe 1411, and the catheter 1422 is drawn in a manner similar to that shown in the embodiment of FIG.
Released into

FIG. 8 is a partial cross-sectional view of a fifth embodiment of the injection device 1400,
0 has a gas tight, variable volume chamber, such as a syringe 1411, which applies pressure to a radioactive fluid from a source vial 14101 located within a vial enclosure 1403 and pumps it into a catheter 1422. Pressure gauge 1414
Indicates the pressure measured in the internal space 1460 of the syringe. 1st syringe 141
The inert fluid within 1 is released into the vial for the radiation source via a passage such as an inlet cannula 1454, displacing the radioactive fluid and exiting the vial via an outlet cannula 1406. To enter the catheter 1422. In this embodiment, the safety hinged latch 1458 is manually disengaged and the slidable housing 1461 containing the source vial is advanced, such that when the septum 1407 is pierced by the cannula 1406, 1454. To
It goes into the vial chamber 1402 for the lower radiation source of the enclosure 1404. For security, the tabs 1476 on the slidable housing may be attached to the main housing 1452.
Engagement with the above catch keeps the source vial 1401 in the dispensing position throughout the operation.

Another safety mechanism is shown in FIG. The safety latch 1478, which operates on vacuum,
As the slidable housing 1461 advances, the vacuum in the source vial chamber 1402 moves the safety latch 1478 and pulls it inward until the slidable housing 1461 and source vial 1401 are brought to that position. Block until you move forward. A vacuum is formed in the vial chamber 1401 for the radiation source via a channel 1479 leading from the main vacuum line 1423.

FIG. 10 is a sectional view of a sixth embodiment of the injection device 1400. In this embodiment, the vial for radiation source 1401 is placed in a vial enclosure 1403, which is sealed by a threaded cap 1482. The chamber housing 1403
A multi-way valve 1409 is housed to control the flow of radiant fluid from the vial into a gas tight variable volume chamber, such as the fluid chamber 1481 of the device. An external knob 1483 controls the position of the valve 1452. Chamber housing 1403
And the cap 1482 functions as a plunger in the main housing 1452 to apply pressure to the fluid chamber 1481 containing the radioactive fluid, and
Discharge the fluid through a passage such as 19 to the dispensing catheter 1422.

[Brief description of the drawings]

FIG. 1 is a partial cross-sectional top view of a first embodiment of the dispensing device of the present invention.

FIG. 2 is a partial cross-sectional front view of the dispensing device.

FIG. 3 is a partial sectional side view of a second embodiment of the dispensing device of the present invention.

FIG. 4 is a sectional view of a stop handle of the device.

FIG. 5 shows another embodiment of the penetrating cannula of the device.

FIG. 6 is a partial cross-sectional side view of a third embodiment of a dispensing device including a second syringe for applying and displacing radioactive fluid from a storage vial.

FIG. 7 is a partial cross-sectional side view of a fourth embodiment of a dispensing device including a second syringe to apply and displace radioactive fluid from a storage vial.

FIG. 8 is a cross-sectional side view of a fifth embodiment of a dispensing device with a slidable storage vial housing for locking.

FIG. 9 is a cross-sectional side view of a fifth embodiment of a dispensing device with a slidable storage vial housing for locking.

FIG. 10 is a cross-sectional side view of a sixth embodiment of a dispensing device, wherein the housing of the storage vial functions as a plunger for discharging radioactive fluid.

[Explanation of symbols]

 1400 Medical radiation dispensing device 1401 Glass bottle for radiation source 1402 Glass bottle for radiation source 1403 Glass bottle chamber for radiation source 1404 Glass bottle for radiation source 1405 O-ring 1406 Penetration cannula 1407 Glass bottle partition for radiation source 1408 Glass bottle connector 1409 Multi-directional valve 1411 Gas Hermetic syringe 1414 Fluid pressure gauge 1415 Main cannula 1416 Syringe housing 1417 Gauge cannula 1418 Connector 1419 Catheter passage 1420 Catheter connector 1421 Selector knob 1422 Radiation distribution balun catheter 1423 Main vacuum line 1424 Vacuum line connector 1425 Vacuum line 1426 Second vacuum evacuation Line 1427 Valve gauge housing 1 28 Valve pressure gauge chamber 1429 Conduction channel 1430 Conduction channel 1431 Second conduction channel 1432 Air space 1433 Syringe plunger 1434 Syringe barrel 1435 O-ring 1436 Air space 1437 Opening 1438 Advance mechanism 1439 Outer handle 1440 Screw release mechanism 1442 Force mechanism 1443 Lock handle 1444 Plunger 1445 Spring 1446 Handle 147 Threaded cap 1450 Vacuum port 1452 Outer housing 1454 Inlet cannula 1455 Space 1456 Shaft 1457 Second syringe 1458 Hinged latch 1461 Housing 1462 Plastic sheath 1472 Air channel 1473 Vacuum channel475 Coupler threaded 1476 tabs 1478 secure the latch 1479 channel 1481 fluid chamber 1482 glass chamber cap 1490 tip

──────────────────────────────────────────────────続 き Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE ), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP , KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW (72) Inventor Apple, Mark, G. United States, 46804 Indiana Fort Wayne Sycamore Hills Drive 1606 (72) Inventor Bates, Brian, El. Exeter Lane 3718 (72) Inventor Deford, John, A. United States, 47408 Indiana Bloomington, Aliki Muse 6051 (72) Inventor Fianot, Neil, E. United States, 47906 Indiana West Lafayette Hamilton Street 3051 (72) Inventor Purdy, James, Dee. United States, 47904 Indiana Lafayette Pereen Street 2008 F-term (reference) 4C082 AE05 AG04

Claims (10)

[Claims] 1. An external device (1422) from a radioactive glass bottle (1401).
In the radioactive gas injection device (1400) for sending radioactive gas to the radioactive gas injection device (1400), an enclosure (1403) accommodating the radioactive gas glass bottle (1401), A gas-tight variable volume chamber (1411, 1452) containing the radioactive gas and selectively communicating with the first passage (1406); and a gas-tight variable volume chamber selectively containing the radioactive gas. (1411) and a selection mechanism (1409) for selectively connecting the external device (1422) with the external device (1422). 2. A plurality of second devices that communicate between the selection mechanism (1409), the gas-tight variable volume chamber (1411), the enclosure (1403), and at least one of the external devices (1422). Passages (1415, 1417, 1419)
2. The apparatus of claim 1 further comprising: selectively conducting between the first passage and one of the second passages. 3. The apparatus according to claim 2, wherein the selection mechanism (1409) comprises a multi-way valve. 4. The radioactive glass vial enclosure (1403) is a gas-tight radioactive glass vial enclosure (1403-1405, 1442-1446, 1).
456-1457, 1461). 5. An enclosure (1403) of said radioactive glass bottle (1401).
2.) The device according to claim 1, wherein the device comprises an element for shielding radioactivity. 6. The radioactive glass vial enclosure (1403) includes a biasing mechanism (1442-1446, 1456-1457, 1461), the radioactive glass vial (1401) and the first passage (1406). 2. The device according to claim 1, wherein the fluid is conducted so that the fluid flows. 7. The vial biasing mechanism (1442) includes a threaded chamber cap (1482), a plunger (1456), and a second inert fluid syringe (1).
457), a second pressure syringe (1457), and a slidable housing (14).
61. The device according to claim 6, comprising at least one of (61). 8. The apparatus of claim 1, wherein the gas tight variable volume chamber (1411) includes a syringe. 9. The device (1400) further comprises a second passage (1415, 141).
7. The device according to claim 1, further comprising a pressure gauge (1414) connected to the gas-tight variable volume chamber (1411). 10. The apparatus according to claim 1, wherein the apparatus (1400) has a vacuum line (1423) extending from the selection mechanism (1409).