JP2001523693A5 - - Google Patents
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- Publication number
- JP2001523693A5 JP2001523693A5 JP2000521746A JP2000521746A JP2001523693A5 JP 2001523693 A5 JP2001523693 A5 JP 2001523693A5 JP 2000521746 A JP2000521746 A JP 2000521746A JP 2000521746 A JP2000521746 A JP 2000521746A JP 2001523693 A5 JP2001523693 A5 JP 2001523693A5
- Authority
- JP
- Japan
- Prior art keywords
- carbohydrate
- agent
- atom
- gadolinium
- attached
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001720 carbohydrates Chemical class 0.000 description 9
- 235000014633 carbohydrates Nutrition 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 6
- 229910052688 Gadolinium Inorganic materials 0.000 description 3
- 125000004429 atoms Chemical group 0.000 description 3
- 230000005298 paramagnetic Effects 0.000 description 3
- 229940077731 Carbohydrate nutrients Drugs 0.000 description 2
- UIWYJDYFSGRHKR-UHFFFAOYSA-N Gadolinium Chemical group [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 210000004027 cells Anatomy 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 125000002353 D-glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229960001031 Glucose Drugs 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- -1 gadolinium glucoside Chemical class 0.000 description 1
- 125000002791 glucosyl group Chemical class C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000000149 penetrating Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 210000004881 tumor cells Anatomy 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 以下を含む生体内で癌性腫瘍を磁気共鳴映像化する剤：
癌性細胞と結合し又はそれを透過することができる炭水化物であって、該炭水化物がそれに結合する常磁性原子を有し；及び
該炭水化物を癌性細胞に送達するのに適した担体。
【請求項２】 常磁性原子がガドリニウムである、請求項１の剤。
【請求項３】 炭水化物がＤ−グルコースでかつガドリニウム原子がその２’位に結合している、請求項２の剤。
【請求項４】 炭水化物がグルコース異性体でかつ常磁性原子がその２’又は３’位のいずれかに結合している、請求項１の剤。
【請求項５】 ガドリニウムグルコシドを含む、請求項１の剤。
【請求項６】 担体が炭水化物を封入するリポソームを含む、請求項１の剤。
【請求項７】 炭水化物に結合した鉄原子を有する単糖類、二糖類及び多糖類の炭水化物から成る群から選択する炭水化物を含む、腫瘍細胞の治療剤。
[Claims]
1. An agent for magnetic resonance imaging of a cancerous tumor in vivo, comprising:
A carbohydrate capable of binding to or penetrating a cancerous cell, wherein the carbohydrate has a paramagnetic atom attached thereto; and a carrier suitable for delivering the carbohydrate to the cancerous cell.
2. The agent according to claim 1, wherein the paramagnetic atom is gadolinium.
3. The agent of claim 2, wherein the carbohydrate is D-glucose and the gadolinium atom is attached at the 2 ′ position.
4. The agent of claim 1, wherein the carbohydrate is a glucose isomer and the paramagnetic atom is attached at either the 2 'or 3' position.
5. The agent of claim 1, comprising gadolinium glucoside.
6. The agent of claim 1, wherein the carrier comprises liposomes encapsulating carbohydrates.
7. A therapeutic agent for tumor cells, comprising a carbohydrate selected from the group consisting of carbohydrates of monosaccharides, disaccharides and polysaccharides having an iron atom bonded to a carbohydrate.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6708197P | 1997-11-20 | 1997-11-20 | |
| US60/067,081 | 1997-11-20 | ||
| US19534198A | 1998-11-18 | 1998-11-18 | |
| US09/195,341 | 1998-11-18 | ||
| PCT/US1998/024663 WO1999026535A1 (en) | 1997-11-20 | 1998-11-19 | Reagent for tumor therapy and/or imaging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001523693A JP2001523693A (en) | 2001-11-27 |
| JP2001523693A5 true JP2001523693A5 (en) | 2006-01-19 |
Family
ID=26747464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000521746A Pending JP2001523693A (en) | 1997-11-20 | 1998-11-19 | Tumor treatment and / or imaging agent |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1032304A1 (en) |
| JP (1) | JP2001523693A (en) |
| CN (1) | CN1299249A (en) |
| AU (1) | AU1464399A (en) |
| CA (1) | CA2310841A1 (en) |
| IL (1) | IL136210A (en) |
| WO (1) | WO1999026535A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1852107A1 (en) * | 2006-04-19 | 2007-11-07 | Nanobiotix | Magnetic nanoparticles compositions and uses thereof |
| CN102242081B (en) * | 2010-03-17 | 2013-01-02 | 中国人民解放军南京军区南京总医院 | Super paramagnetic iron oxide particle marked cell for magnetic-resonance tracing in vivo |
| CN102078624B (en) * | 2010-12-23 | 2012-07-25 | 华东理工大学 | Efficient Gd-loaded liposome preparation and preparation method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE465907B (en) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | DIAGNOSTIC AGENT CONTENT AND PARAMAGNETIC METAL |
| US5707604A (en) * | 1986-11-18 | 1998-01-13 | Access Pharmaceuticals, Inc. | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles |
| US4822594A (en) * | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
| US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
| US5268165A (en) * | 1990-10-16 | 1993-12-07 | Biomedical Frontiers, Inc. | Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging |
| US5143716A (en) * | 1991-02-01 | 1992-09-01 | Unger Evan C | Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region |
-
1998
- 1998-11-19 JP JP2000521746A patent/JP2001523693A/en active Pending
- 1998-11-19 CA CA002310841A patent/CA2310841A1/en not_active Abandoned
- 1998-11-19 WO PCT/US1998/024663 patent/WO1999026535A1/en not_active Application Discontinuation
- 1998-11-19 AU AU14643/99A patent/AU1464399A/en not_active Abandoned
- 1998-11-19 IL IL13621098A patent/IL136210A/en not_active IP Right Cessation
- 1998-11-19 EP EP98958644A patent/EP1032304A1/en not_active Withdrawn
- 1998-11-19 CN CN98812156A patent/CN1299249A/en active Pending
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