JP2001518514A - 殺菌剤及び有機溶媒の細菌耐性を減少させる方法及び組成 - Google Patents

殺菌剤及び有機溶媒の細菌耐性を減少させる方法及び組成

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Publication number
JP2001518514A
JP2001518514A JP2000514662A JP2000514662A JP2001518514A JP 2001518514 A JP2001518514 A JP 2001518514A JP 2000514662 A JP2000514662 A JP 2000514662A JP 2000514662 A JP2000514662 A JP 2000514662A JP 2001518514 A JP2001518514 A JP 2001518514A
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Japan
Prior art keywords
locus
expression
bacterial
outward flux
flux pump
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Pending
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JP2000514662A
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English (en)
Japanese (ja)
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JP2001518514A5 (https=
Inventor
スチュアート ビー. レヴィー
Original Assignee
トルスティーズ オブ トゥフツ カレッジ
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Application filed by トルスティーズ オブ トゥフツ カレッジ filed Critical トルスティーズ オブ トゥフツ カレッジ
Publication of JP2001518514A publication Critical patent/JP2001518514A/ja
Publication of JP2001518514A5 publication Critical patent/JP2001518514A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245Escherichia (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2000514662A 1997-10-03 1998-03-20 殺菌剤及び有機溶媒の細菌耐性を減少させる方法及び組成 Pending JP2001518514A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6089897P 1997-10-03 1997-10-03
US60/060,898 1997-10-03
PCT/US1998/005671 WO1999017791A1 (en) 1997-10-03 1998-03-20 Methods and compositions for reducing bacterial tolerance of disinfectants and organic solvents

Publications (2)

Publication Number Publication Date
JP2001518514A true JP2001518514A (ja) 2001-10-16
JP2001518514A5 JP2001518514A5 (https=) 2005-12-22

Family

ID=22032436

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000514662A Pending JP2001518514A (ja) 1997-10-03 1998-03-20 殺菌剤及び有機溶媒の細菌耐性を減少させる方法及び組成

Country Status (6)

Country Link
US (3) US6068972A (https=)
EP (1) EP1019076A4 (https=)
JP (1) JP2001518514A (https=)
AU (1) AU751014B2 (https=)
CA (1) CA2305528A1 (https=)
WO (1) WO1999017791A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9910443A (pt) 1998-05-18 2001-01-02 Upjohn Co Aperfeiçoamento da atividade de agentes antibacterianos de oxazolidinona usando-se derivados de arginina
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
WO2002016940A2 (en) * 2000-08-23 2002-02-28 Genome Therapeutics Corporation Genomics-assisted rapid identification of targets
CA2434254C (en) * 2001-01-12 2013-08-13 Board Of Regents, The University Of Texas System Novel antiseptic derivatives with broad spectrum antimicrobial activity for the impregnation of surfaces
WO2003006626A2 (en) * 2001-07-13 2003-01-23 Trustees Of Tufts College CRYSTAL STRUCTURE OF A MarR FAMILY POLYPEPTIDE
US20060084678A1 (en) * 2001-07-13 2006-04-20 Paratek Pharmaceuticals, Inc. Methods for identifying and using MarR family polypeptide binding compounds
US7075582B2 (en) 2001-07-13 2006-07-11 Paratek Pharmaceuticals, Inc. Methods for identifying and using MarR family polypeptide binding compounds
US20050255538A1 (en) * 2002-03-15 2005-11-17 Buxser Stephen E Methods for screening for AcrAB efflux pump inhibitors
WO2004062674A2 (en) * 2003-01-07 2004-07-29 Paratek Pharmaceuticals, Inc. Substituted polyamines as inhibitors of bacterial efflux pumps
HUE045608T2 (hu) * 2003-06-06 2020-01-28 Univ Texas Antimikrobiális öblítõoldatok
WO2005000837A1 (en) * 2003-06-19 2005-01-06 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
JP2007522835A (ja) * 2004-01-20 2007-08-16 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 医療装置に消毒組成物をコーティングする、および含浸させる方法
US20070154621A1 (en) 2005-11-18 2007-07-05 Issam Raad Methods for coating surfaces with antimicrobial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384259A (en) * 1991-12-06 1995-01-24 American Cyanamid Company Construct and method for expression of tetracycline resistance genes in E. Coli
TW318189B (https=) * 1991-12-06 1997-10-21 American Cyanamid Co
ATE173510T1 (de) * 1992-08-28 1998-12-15 Tufts College Prüfung auf ein vielfache resistenz gegen antibiotika verursachendes operon
US5989832A (en) 1995-04-21 1999-11-23 Microcide Pharmaceuticals, Inc. Method for screening for non-tetracycline efflux pump inhibitors

Also Published As

Publication number Publication date
EP1019076A1 (en) 2000-07-19
CA2305528A1 (en) 1999-04-15
AU751014B2 (en) 2002-08-08
EP1019076A4 (en) 2002-01-23
US20030171317A1 (en) 2003-09-11
US6068972A (en) 2000-05-30
WO1999017791A1 (en) 1999-04-15
US6448006B1 (en) 2002-09-10
AU6578598A (en) 1999-04-27

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