JP2001340373A - Tool for inserting intraocular insertion lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a tool for inserting an intraocular insertion lens constituted by imparting an antimicrobial property or a sterilizing material. SOLUTION: A part or all parts of the tool for inserting an intraocular insertion lens is fabricated by a material having an antimicrobial or sterilizing property to prevent germs form entering eyes during an operation. More specifically, the antimicrobial property or the sterilizing property can be imparted according to one of the following ways: A compound having an antimicrobial or sterilizing property is kneaded in a material consisting the tool for inserting an intraocular insertion lens. The compound is allowed to reacted chemically to introduce into side chains of polymer serving as a material of the tool for inserting an intraocular insertion lens by a reaction such as copolymeterization of the compound with polymer serving as a material of the tool for inserting an intraocular lens. Otherwise, the compound is fixed on the surface as a thin film. Thus, the tool for inserting an intraocular insertion lens is provided with the antimicrobial property or the sterilizing property.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a device for inserting an intraocular lens used for inserting the intraocular lens into the eye.

[0002]

2. Description of the Related Art Conventionally, as a cataract operation, a technique of inserting an intraocular lens has been widely used. A serious complication at the time of insertion of an intraocular lens is endophthalmitis caused by the invasion of bacteria into the body, particularly into the eye, during surgery. Special forceps or a special injector made of plastic or metal has been used as an instrument for inserting an intraocular lens, and direct contact between the wound and the intraocular lens when the intraocular lens is inserted. It is said that an injector system that can avoid the above is preferable for preventing endophthalmitis.

[0003]

However, among the conventional insertion devices, the metal forceps can be sterilized by boiling water immediately before the operation, but the injector using plastic as a main constituent element has a high temperature. It was difficult to sterilize by boiling, and there was no injector made of an antibacterial or bactericidal material, and bacterial infection during surgery could not be ruled out. Hereinafter, the term "antibacterial property" means the property of inhibiting the growth of bacteria attached to the material, and the term "bactericidal" means the property of killing the bacteria attached to the material. The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an antibacterial property or a bactericidal property to an intraocular lens insertion device itself, thereby causing an ocular insertion lens to be inserted. An object of the present invention is to provide a device for inserting an intraocular lens which prevents bacterial infection.

SUMMARY OF THE INVENTION In order to achieve the above object, the present invention provides a method of making a surgical instrument by forming a part or the whole of an insertion device for an intraocular lens using an antibacterial or bactericidal material. Sometimes it prevents bacteria from entering the eye. In order to impart antibacterial or bactericidal properties to the insertion device, specifically, a compound having antibacterial or bactericidal properties is kneaded into a material constituting an insertion device for an intraocular lens, or the compound is injected into the eye. Either a chemical bond is introduced into the side chain of the macromolecule that is used as the insertion device material for the intraocular insertion lens through a reaction such as copolymerization with the polymer that is used as the insertion device material for the insertion lens, or the compound is applied to the surface. The anti-bacterial or sterilizing properties are imparted to the device for inserting an intraocular lens by fixing it as a thin film to the eye. In addition, by introducing a photocatalyst having a function of converting oxygen in the air or oxygen molecules in the air itself into active oxygen by visible light or ultraviolet light by the above-described method to an insertion device of an intraocular insertion lens, An antibacterial property is given to the insertion device of the lens for internal insertion.

[0004] Since the actual insertion operation of the lens for intraocular insertion is performed under a microscope, the site where the operation is performed is irradiated to some extent with strong light to ensure the visibility of the operator. At this time, if a photocatalytic antibacterial agent or a bactericide is present in the device for inserting an intraocular lens, or if the device for inserting an intraocular lens itself has a photocatalytic antibacterial action or a bactericidal action, the photocatalyst is activated. Since the antimicrobial action and bactericidal action are exerted locally on the part irradiated with light by the action, and only during the period of irradiating light, it is possible to obtain safe and efficient antibacterial or bactericidal action. it can.

[0005] What is currently known as an antibacterial agent includes:
Examples include polymers having a cationic group represented by a quaternary ammonium group or a phosphonium group in the main chain or side chain, oxidoreductases derived from living organisms, metal ions, and organic salt compounds. For example, chitin, chitosan, horseradish peroxidase, mustard extract, hinokitiol, natural products such as tea extract antibacterial agent, zinc oxide fine particles, silver-containing zeolite, inorganic compounds such as silver-containing zirconium phosphate, and organic ammonium salts, organic Organic compounds such as phosphonium salt-based compounds are exemplified.

[0006] Titanium oxide has a property of exciting ground-state oxygen by irradiation with ultraviolet light to generate active oxygen. The active oxygen excited and generated here has a very high reactivity but a short life, and after exhibiting a high sterilizing ability,
Quickly deactivated to ground state oxygen. Therefore, compared to antibacterial agents and bactericides utilizing the toxicity of the compound itself,
It has very little adverse effect on the environment and the human body when actually used, and is preferable for the purpose.

Further, some photoreactive organic dyes have the ability to generate active oxygen like titanium oxide,
It has absorption in the visible light region longer than the absorption wavelength region of titanium oxide, and can exhibit the same antibacterial and bactericidal activities as titanium oxide by irradiating with visible light. Is more preferable than titanium oxide because it is not necessary to use visible light.

[0008] Whether the compounds having antibacterial and bactericidal properties mentioned above are used for the material of the device for inserting an intraocular lens, or these compounds are mixed with the material of the device for inserting an intraocular lens. Or chemical copolymerization (including covalent bond, hydrogen bond, coordination bond, and ionic bond) by performing a copolymerization reaction on the polymer used as the insertion device material of the lens for intraocular insertion, etc.
To obtain an antibacterial or bactericidal intraocular lens insertion device by bonding to the material of the intraocular lens insertion device by using the method described above, or by introducing a thin film on the surface of the intraocular lens insertion device. Can be.

The part for imparting antibacterial or bactericidal properties to the insertion device of the intraocular lens is desirably the nozzle portion at the tip of the device, which is the portion to be inserted into the eye, but is not limited to this. It is possible to improve the sanitary condition around the surgical site or the sanitary condition of the lens for insertion into the eye before insertion by imparting sterilization to the shaft for pushing the lens or the lens. For example, imparting antibacterial or bactericidal properties to all parts of the intraocular lens insertion device has the effect of killing or suppressing the growth of bacteria adhering to the operator's hands and other surgical instruments and devices. To prevent intraoperative bacterial infections.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, an embodiment of an antimicrobial or bactericidal intraocular lens insertion device according to the present invention will be described in detail. Antibacterial agents and bactericides used in the present invention are bacteria that cause bacterial endophthalmitis after cataract surgery, bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, Acne bacteria, Enterococci, and Escherichia coli. Antibacterial activity,
Or those that exhibit bactericidal activity, for example, a polymer having a quaternary ammonium salt in the main chain or side chain, metal ions such as silver and copper, titanium oxide, metal phthalocyanine complexes and the like. It is not limited. Examples are shown below, but the present invention is not limited to these examples.

The polymer having an antibacterial or bactericidal quaternary ammonium salt is a polymer derived from a living body represented by chitin or chitosan, or represented by the following general formula [I]. Synthetic compounds are included.

Embedded image Provided that R ₁ , R ₂ , and R ₃ are hydrogen or a group having 1 to 2 carbon atoms.
0 represents a linear or branched saturated hydrocarbon group,
X represents an anion. n is an integer of 2 or more.

Other preferable examples of the cationic polymer include a polymer containing an ammonium group represented by the following general formula [II] of the following [Chemical Formula 2].

Embedded image However, R ₁ , R ₂ , and R ₃ are hydrogen or C 1-20.
X represents a linear or branched saturated hydrocarbon group of
Represents an anion, and n is an integer of 2 or more.

Further, as an example of the cationic polymer, a polymer containing a pyridinium salt represented by the following general formula [III] of the following [Chemical Formula 3] can be mentioned.

Embedded image Here, X represents an anion, and n is an integer of 2 or more.

The antibacterial polymer composed of a polymer containing a quaternary ammonium salt mentioned above is used as a material for an insertion device for an intraocular lens, or is used as a material for an insertion device for an intraocular lens. Knead or coat the surface of the insertion device for intraocular lenses, or use polyethylene, polypropylene, polyacetal, polystyrene,
By synthesizing a copolymer such as polycarbonate with a raw material of a conventional insertion device material for an intraocular lens, it is possible to obtain an insertion device material for an intraocular lens having antibacterial properties and bactericidal properties.

With respect to titanium oxide, it is possible to obtain a sterilizing intraocular lens insertion device by coating a titanium oxide thin film on the surface of the intraocular lens insertion device. It is possible to form a titanium oxide film on the surface of an insertion device of an intraocular lens by a sol-gel method.

[0016] Further, by kneading ultrafine titanium oxide into a polymer material such as polyethylene, polypropylene, polyacetal, polystyrene, polycarbonate, etc., which is a material for an intraocular lens, a bactericidal intraocular insertion is performed. It is possible to obtain a tool for inserting a lens.

In a device for inserting a bactericidal intraocular lens using titanium oxide, a large amount of oxygen present in the air due to energy transfer from titanium oxide activated under irradiation of a surgical lamp during cataract surgery. Is excited. Excited oxygen such as singlet oxygen with high reactivity generated here attacks bacterial cell constituents to exhibit bactericidal properties.

By using a photoreactive organic dye compound in addition to the titanium oxide shown here, oxygen excitation by visible light is possible. In this case, visible light having a longer wavelength than titanium oxide can be used. It is valid. In this case, as in the case of titanium oxide, oxygen is excited by energy transfer from the photoreactive organic dye compound that is photoexcited to oxygen present in the atmosphere, and sterilization is exhibited by the excited oxygen thus formed. Examples of the photoreactive organic dye compound include, but are not limited to, methylene blue, eosin, rose bengal, metal porphyrin, metal phthalocyanine, metal naphthalocyanine and the like. These compounds may be coated on the surface of the device for inserting an intraocular lens, or may be kneaded into the material of the device for inserting an intraocular lens, or may be chemically modified into a polymer material that is used as a material for an intraocular lens. By bonding, photostericidal properties similar to titanium oxide can be imparted.

Such organic dyes include, but are not limited to, methylene blue, eosin Y, metal porphyrin complex, metal phthalocyanine complex and the like.

An embodiment of the present invention will be described below. Example 1 Commercially available poly (vinylbenzyl chloride) (hereinafter, PVBC) was dissolved in dimethyl sulfoxide (hereinafter, DMS0),
Tetraethylamine was added and the mixture was refluxed to convert chlorine to a triethylammonium salt. The solution after the reaction was dropped into toluene to obtain a solid of poly (vinylbenzyltriethylammonium chloride). Poly (vinylbenzyltriethylammonium chloride), which was precipitated by dropping in toluene and dried under reduced pressure, was melt-mixed with polypropylene pellets to prepare a mixed polymer of poly (vinylbenzyltriethylammonium chloride) and polypropylene. It was molded to obtain a device for inserting a sterilizable intraocular lens.

Example 2 A commercially available titanium oxide powder for photocatalyst was melt-mixed with polypropylene constituting the nozzle portion of an insertion device for an intraocular lens, thereby producing a polypropylene containing titanium oxide. An injection device for a molded and photosterilizable intraocular lens was prepared.

Example 3 A commercially available zinc (II) tetra-t-butylphthalocyanine and a commercially available polycarbonate were dissolved in dichloromethane. The solvent was removed under reduced pressure to obtain a polycarbonate in which zinc (II) tetra-t-butylphthalocyanine was uniformly dispersed. By molding this, an insertion device for a photosterilizing intraocular lens was prepared. [Example 4] Commercially available PVBC was dissolved in DMSO, and commercially available zinc (II) tetracarboxyphthalocyanine was added thereto, pyridine was further added, and the mixture was refluxed. By dropping the solution after the reaction in toluene, a solid of poly (vinylbenzylpyridinium chloride) containing zinc phthalocyanine in a part of a side chain by a covalent bond was obtained. Dried zinc phthalocyanine-containing poly (vinylbenzylpyridinium chloride)
Was melt-mixed with polypropylene pellets and molded to obtain a photodisinfecting intraocular lens insertion device made of a mixed polymer.

The device for inserting an intraocular lens according to this embodiment has a photoinduced bactericidal action by generating active oxygen by photoexcitation of zinc phthalocyanine upon irradiation with visible light, in addition to the bactericidal properties of the mixed polymer itself.

Claims (4)

[Claims] 1. An intraocular lens insertion device for inserting an intraocular lens into an eye, wherein a part or the entire insertion device to be inserted into the eye is antibacterial or bactericidal. An insertion device for an intraocular lens, which is made of a material having: 2. The intraocular lens insertion device according to claim 1, wherein the material having antibacterial or bactericidal properties is an antibacterial polymer having a cationic substituent in a main chain or a side chain. 3. The intraocular insertion according to claim 1, wherein the material having antibacterial or bactericidal properties is a material that exhibits an antibacterial or bactericidal action by photocatalysis using visible light and near-ultraviolet light. Lens insertion device. 4. The intraocular lens insertion device according to claim 3, wherein the antibacterial or bactericidal material is titanium oxide.