JP2001327524A - External patch - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external patch which is made securer in the tight adhesion of a moisture-containing tacky adhesive layer and a supporting body controlled particularly in moisture permeability to a specific range by improving the affinity between both, is improve in the shape holdability of the tacky adhesive layer by decreasing the moisture in the moisture-containing tacky adhesive layer at need and is made additionally higher in a cooling effect and longer in the cooling persistent time by previously depositing moisture on the supporting body and laminating the moisture-containing tacky adhesive layer on the supporting body deposited with the moisture. SOLUTION: The supporting body of the patch of a dermatological affixation type which is formed by laminating a tacky adhesive layer containing moisture on the one side surface of a film or sheet shape supporting body is formed of a material which is formed by laminating cloth and cloth, partially bonding the laminate and controlling the adhesive area to regulate the moisture permeability to the range of 2,800 to 4,400 g/m2.24 hr. The moisture is deposited on this supporting body at 20 to 400 wt.% of its own weight of the supporting body before the lamination of the tacky adhesive layer.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external patch which is applied to an outer skin and has a cooling effect and / or a compressing effect that is maintained and developed over a long period of time. In particular, it controls the moisture permeability of a support within a specific range. By doing so, the latent heat of evaporation of the water in the pressure-sensitive adhesive layer containing water can be controlled, thereby realizing a cooling effect and / or a compressing effect over a long period of time, as well as stuffiness, rash, itching, red spots, etc. It does not cause skin irritation and has good usability and improves safety and hygiene.In addition, when using a support whose moisture permeability is controlled to a specific range, the support must be pre-moistened. And by laminating the moisture-containing pressure-sensitive adhesive layer on the support supporting the moisture, the affinity between the moisture-containing pressure-sensitive adhesive layer and the support is improved, and the adhesion between the two is strengthened. Depending on the moisture content Or by decreasing the adhesive layer to improve the shape retention of the adhesive layer, or a cooling effect to further large, to external patch was further increased cooling duration.

[0002]

2. Description of the Related Art In general, as an external patch which is applied to the outer skin and administers a drug into a living body from the applied site, an adhesive layer to be applied to the outer skin is applied to one side of a film or sheet support. Are laminated, and the pressure-sensitive adhesive layer contains a necessary drug.

[0003] Another example of the external patch is a film- or sheet-shaped support in which a pressure-sensitive adhesive layer containing a poultice that exhibits a poultice effect is laminated on one side thereof. It is used as a poultice for compressing and relieving inflammation and the like of local parts of the human body.

[0004] Further, other external patches include fever associated with illnesses such as colds, or fever relief or cooling of application sites in order to make users feel comfortable during work or daily life. So-called cooling / heating sheets have been proposed.
This external patch (cooling sheet) is formed by laminating an adhesive layer containing water or a drug that gives a refreshing sensation with water, or a fever-reducing agent on one side of the support, so that the application site of the human body is formed. One that cools (relieves fever) or gives a user a refreshing or comfortable feeling.

[0005] By the way, in such an external patch, if a non-breathable support is used as a support, the application site may be stuffy, rash, red spots, etc.
Alternatively, bodily fluid such as sweat stays between the application site and the external patch, and germs proliferate, causing itching and skin irritation, which poses a problem from the viewpoint of safety and hygiene.

For this reason, in the past, in external patches such as compresses and cooling / heating sheets, use of a cloth such as a non-woven fabric or a knitted cloth as a support prevents the occurrence of stuffiness, rash, itching and red spots. It eliminates the cause of skin irritation and improves the feeling of use and texture.

The non-woven fabric is formed by partially bonding or heat-sealing an assembly of fibers (short fibers or filaments) such as polyamide, polyester, polypropylene or rayon using mechanical, chemical or heating means. Examples include: In this nonwoven fabric, gaps penetrating between the fibers on the front and back, that is, pores are formed.

[0008] When this nonwoven fabric is used as a support, the effects of preventing stuffiness, rash, itching and red spots, eliminating the cause of skin irritation, and improving the feeling of use and texture can be obtained. It has.

[0009]

In the conventional external patch, the nonwoven fabric as the support is formed by simply partially adhering or heat-bonding short fibers as described above.

[0010] For this reason, the pores communicating with the front and back surfaces between the fibers in the nonwoven fabric are extremely large, and as a result, the drug in the adhesive layer in the external patch, the compress, the cooling agent (drug) and the water Oozes out on the surface of the nonwoven fabric, and water and volatile components in the adhesive layer evaporate.

[0011] That is, a conventional external patch using only a nonwoven fabric having relatively large pores communicating with the front and back surfaces as a support is characterized in that, during storage or use, a pressure-sensitive adhesive is formed from the pores communicating with the front and back surfaces of the nonwoven fabric. The drug in the layer is easy to seep out, and excessive evaporation of water and volatile components occurs.

When the drug exudes, the active ingredient of the drug in the external patch is reduced, and the expected therapeutic effect cannot be obtained. In addition, if a drug leaks out from the surface of the nonwoven fabric during storage or use, the drug stains clothing, for example, causes coloring, or deteriorates the appearance of an external patch, thereby causing a problem of lowering commercial value. Occurs.

Furthermore, when the evaporation of moisture and volatile components (eg, volatile drugs) becomes excessive, the composition of the pressure-sensitive adhesive layer changes,
As a result, the medicinal effect is disturbed, and the treatment effect, the cooling effect, and the continuation of the compressing effect for a long time cannot be expected.

The inventor of the present invention has conducted intensive studies in order to solve the above-mentioned problems. As a result, the cloth is laminated and partially bonded to each other, and by controlling the bonding area, the moisture permeability becomes 2,2.
By using a range of 800~4,400g / m 2 ^· 24hr as a support drug and moisture in the adhesive layer is a finding that it is possible to prevent the exuding to the outside of the support Obtained.

That is, as a support, a cloth and a cloth are laminated and partially adhered, and by controlling the adhesion area, the moisture permeability is 2,800 to 4,400 g / m ² · 24 h.
It has been found that by using a material having a range of r, it is possible to prevent deterioration of appearance, staining of clothes, and reduction in drug use efficiency due to seepage of the drug in the pressure-sensitive adhesive layer.

In particular, when a support having such a special structure is used, the evaporation of moisture, volatile components (eg, volatile drugs) and the like in the pressure-sensitive adhesive layer is suppressed, and In addition to maintaining excellent cooling and compressing effects, it also prevents stuffiness, rash, itching, red spots, etc. to improve safety and hygiene, prevents skin irritation, and improves usability. Obtained knowledge to improve.

Further, as a support, a cloth and a cloth are laminated and partially adhered, and by controlling the adhesion area, the moisture permeability is 2,800 to 4,400 g / m ² · 24 h.
When the one in the range of r is used, the texture of the external patch is improved by this nonwoven fabric, or the moisture retention is improved,
In addition, it has been found that, particularly during use, the feeling of use of the external patch is improved.

Furthermore, as the support, the moisture permeability by controlling the adhesion area as well as bond the cloth and the cloth partially laminated 2,800~4,400g ^/ m 2 · 24h
It has been found that the use of a material having a range of r improves the appearance of the product, improves the value of the product, and improves the usability.

Above all, in particular, as the support, the moisture permeability is in the range of 2,800 to 4,400 g / m ² · 24 hr, and a cloth such as a nonwoven fabric or a knitted cloth is laminated on one or both sides thereof. When the pressure-sensitive adhesive layer is laminated on the cloth surface, the surface portion of the pressure-sensitive adhesive layer enters the gaps of the cloth, thereby improving the anchoring property, and after applying the external patch of the present invention to the skin,
It has been found that cohesive failure does not occur when peeling and removing.

In addition, as described above, the present inventor does not control the moisture permeability of the support by changing the adhesive area between the cloth and the cloth, regardless of the structure of the support. The support has a moisture permeability of 2,800 to 4,400
With distribution in the range of g / m 2 ^· 24hr, to give the same effect as in the previous case, the finding that effect.

In particular, when using a support whose moisture permeability is controlled to a specific range as described above, the present inventor pre-supports moisture on the support, and the support supporting the moisture contains water. By laminating the pressure-sensitive adhesive layer, the affinity between the water-containing pressure-sensitive adhesive layer and the support is improved to strengthen the adhesion between them, or the pressure-sensitive adhesive is reduced by reducing the water-containing pressure-sensitive adhesive layer as necessary. It has been found that the shape retention of the layer can be improved, the cooling effect can be further increased, and the cooling duration can be further increased.

The present invention has been completed on the basis of the above-mentioned findings, and by using a support having a specific range of moisture permeability as a support used in this kind of external patch,
Deterioration of appearance due to the drug in the pressure-sensitive adhesive layer seeping out of the support, soiling of clothing, preventing a decrease in drug use efficiency, and in particular, laminating and partially bonding cloth to cloth By controlling the adhesion area, the moisture retention in the pressure-sensitive adhesive layer is improved, and furthermore, the moisture and volatile components are prevented from evaporating, and the cooling effect or the compressing effect is maintained for a long time. It is an object of the present invention to provide an external patch which prevents the occurrence of skin irritation such as rash, itching, and red spots to thereby greatly improve safety and hygiene, and which further improves the feeling of use.

In addition, in the present invention, in particular, when using a support whose moisture permeability is controlled to a specific range, the support is preliminarily loaded with moisture, and the moisture-supported adhesive is placed on the support loaded with moisture. By laminating the layers, the affinity between the moisture-containing pressure-sensitive adhesive layer and the support is improved to strengthen the adhesion between the two, or the moisture-containing pressure-sensitive adhesive layer is reduced by reducing the pressure-sensitive adhesive layer if necessary. It is an object of the present invention to provide an external patch having improved shape retention properties, a greater cooling effect, and a longer cooling duration.

[0024]

Means for Solving the Problems In the first external patch of the present invention (hereinafter referred to as the first external patch of the present invention), in order to achieve the above object, a film-like or sheet-like support is used. In a skin-adhesive patch in which a water-containing pressure-sensitive adhesive layer is laminated on one side of the body, the support is formed by laminating a cloth and a cloth and partially bonding and controlling the bonding area thereof. By doing, the moisture permeability is 2,800 ~
4,400 g / m ² · 24 hr, and the support is provided with water before lamination of the pressure-sensitive adhesive layer with 20 to 400% by weight of its own weight.
It is characterized by being carried.

That is, the most significant feature of the first external patch of the present invention is that, in this type of external patch, the adhesive layer contains a large amount of water, and the support is partially laminated with cloth. By controlling the bonding area, the water vapor permeability is 2,800 to 4,400 g / m ² · 24 hr.
And that the support carries 20 to 400% by weight of its own weight before laminating the pressure-sensitive adhesive layer. By the way, in the present invention, three or more cloths may be stacked to control the moisture permeability.

Hereinafter, the first external patch of the present invention will be described in more detail. The cloth used in the first external patch of the present invention includes a nonwoven fabric, a woven fabric or a knitted fabric. Therefore, the support used in the present invention includes a nonwoven fabric and a nonwoven fabric, a nonwoven fabric and a woven fabric, a nonwoven fabric and a knitted fabric, and a woven fabric. And a knitted fabric or a knitted fabric and a knitted fabric are laminated and partially adhered to each other.

In the first external patch of the present invention, a support having a specific moisture permeability is used by laminating and partially adhering a cloth and controlling the adhesion area thereof. Partial adhesion between the fabric and the cloth includes adhesion, heat bonding or heat welding.

Here, the adhesion or heat bonding is to bond the cloth with the cloth by using a pressure-sensitive adhesive or a heat-sensitive adhesive (hot melt). Instead of using an adhesive (hot melt), a heat-fusible (heat-sealable) cloth is directly fused to the cloth.

In the first external patch of the present invention, the type of cloth is not particularly limited, and any of natural fibers and artificial fibers can be used.

The natural fibers include, for example, cotton, kapok, flax, ramie, hemp, jute, jujube, manila hemp,
Vegetable fibers such as sisal and coyer fiber; and animal fibers such as silkworm silk, tussah silk, wool (sheep), cashmere hair, camel hair, alpaca hair, mohair, rabbit hair and the like.

The artificial fibers include, for example, regenerated fibers such as artificial silk, suf, viscose and Bemberg (registered trademark), polyamide fibers (nylon and the like), polyester fibers (Tetron (registered trademark), terylene, etc.). , Decron, etc.), polyacrylic fibers (aulon, xlan, bonnel, cashmere, kanecaron, etc.), polyvinyl alcohol fibers (vinylon), polyalkylene paraoxybenzoate fibers (benzoate), polyurethane fibers (polyurethane) [span Tex], polyvinylidene chloride fiber (vinylidene),
Synthetic fiber such as polyvinyl chloride fiber (polyvinyl chloride), polyacrylonitrile fiber, polyethylene fiber (polyethylene), polypropylene fiber (polypropylene), polyclar, polypropylene fiber (pyrene), or artificial acetate fiber Semi-synthetic fibers produced by copolymerizing a natural substance and a synthetic substance are exemplified.

In the first external patch of the present invention, it is necessary for the support to have air permeability, and this air permeability can be maintained for a long time such as a cooling effect and a compressing effect of the external patch, a preservability, and a feeling of use. In addition, it has a significant effect on the occurrence of stuffiness, rash, itching, red spots, etc. and skin irritation, i.e., safety and hygiene. is there.

In order to control the air permeability with high accuracy, it is preferable to control the air permeability of the support by moisture permeability.
Specifically, the moisture permeability is 2,800 to 4,4 by the Lissi method.
It should be set within the range of 00g ^/ m 2 · 24hr.

The moisture permeability is 2,800 g / m ² · 24
If it is less than hr, adverse effects such as stuffiness, rash, itching, red spots and skin irritation are likely to occur, and the safety and hygiene will decrease,
Elevated temperature of the pressure-sensitive adhesive layer, not only can not be expected sufficiently cooling effect, it is not preferable because feeling is deteriorated, while when it exceeds 4,400g / m 2 ^· 24hr, outside of the drug support It is easy to seep out and may cause the clothes to be stained, and water and volatile components (volatile drugs) in the adhesive layer
Evaporates to cause a problem in the medicinal effect, and a long-term cooling effect or compressing effect cannot be expected.

Accordingly, from these viewpoints, it is preferable that the moisture permeability of the support is set in the range of 2,800 to 4,400 g / m ² · 24 hr.

In the first external patch of the present invention, the above-mentioned support carries 20 to 400% by weight of water of its own weight before laminating the pressure-sensitive adhesive layer, When the amount of water carried by the support is less than 20% by weight with respect to the weight of the support, the amount of water is too small to support the water. In either case, the water content becomes too large, and the handleability deteriorates, and the productivity may deteriorate.

As a method for supporting moisture on the support,
Although not particularly limited, specific examples include spraying, spraying, impregnating or dipping, and of these, one or a combination of two or more may be used.

By adopting such a constitution, the affinity between the moisture-containing pressure-sensitive adhesive layer and the support is improved, and the adhesion between the two is increased. It is possible to improve the retentivity of the pressure-sensitive adhesive layer by reducing the content, to increase the cooling effect, and to prolong the cooling duration.

That is, in the first external patch of the present invention,
The most significant features are as follows. That is, as the pressure-sensitive adhesive layer containing water, various components are used depending on the application.In this case, depending on the types and compositions of the components, sufficient shape retention may not be obtained. At this time, it is possible to use the water carried on the support to reduce the amount of water and secure the shape retention property, while obtaining the required cooling effect and cooling time.

In the second patch for external use according to the present invention (hereinafter referred to as the second patch for external use of the present invention), in order to achieve the above object, a film-like or sheet-like support is used. on one side, in the outer skin stuck shaped patch where the adhesive layer is laminated which contains water, the support is its moisture permeability is formed by distribution in the range of 2,800~4,400g ^/ m 2 · 24hr Further, before laminating the pressure-sensitive adhesive layer on the support, moisture is applied to the support.
It is characterized by being loaded with 0 to 400% by weight.

In the first external patch of the present invention, in the external patch, the support is formed by laminating a cloth and a cloth and partially adhering to each other, and by controlling the adhesion area thereof, the moisture permeability is specified. On the other hand, in the second external patch of the present invention, the moisture permeability is controlled to 2,800 to 4, by controlling the thickness, density, and basis weight of the cloth for forming the support. 400g ^/ m 2 · 24
hr, and the support includes:
The most significant feature is that moisture is supported by 20 to 400% by weight of the weight of the support before laminating the pressure-sensitive adhesive layer.

That is, in the second external patch of the present invention, the cloth is laminated and partially adhered, and the moisture permeability is not adjusted to a specific range by controlling the adhesion area. 2,800 ~
And than distribution in the range of 4,400g / m 2 ^· 24hr are used, therefore, as the fabric is than nonwoven and woven or knitted used, also, the present invention first external patch as the type of cloth Since it is the same as the agent, it is omitted to avoid repeated explanation.

The moisture permeability is 2,800 g / m ² · 24
If it is less than hr, adverse effects such as stuffiness, rash, itching, red spots and skin irritation are likely to occur, and the safety and hygiene will decrease,
Elevated temperature of the pressure-sensitive adhesive layer, not only can not be expected sufficiently cooling effect, it is not preferable because feeling is deteriorated, while when it exceeds 4,400g / m 2 ^· 24hr, difficult to carry water In addition, the drug is likely to seep out of the support, and the clothes may be stained, or the moisture and volatile components (volatile drug) in the adhesive layer evaporate, and the medicinal effect is hindered. This is not preferable because a long-term cooling effect or a compressing effect cannot be expected.

Further, in the second external patch of the present invention, before laminating the pressure-sensitive adhesive layer, the support carries water at 20 to 400% by weight of the weight of the support. The same action and effect as those of the first external patch of the invention can be obtained.

By the way, the Lyssey method (Lyssy method) is a method based on industrial standards of various countries around the world.
In IS Z 0208 and JIS K 7129, the temperature is set to be maintained at 40 ° C. and the relative humidity difference is set to 90% RH. Therefore, in this apparatus, the lower chamber in the state of 100% relative humidity and the highly sensitive humidity sensor The measurement sample is inserted into the boundary surface of the upper chamber where is installed, and the relative humidity of the upper chamber with the humidity sensor is set to 10% R.
H (100% -90%), around which a range of about -1% to + 1%, ie, about 9% to about 11%.
This is a method of measuring the time (several seconds) necessary for the humidity to increase and comparing the result with the calibration result obtained under the same conditions using a standard sample whose transmittance is known in advance to obtain the transmittance.

In the present invention, when a support is formed by laminating a cloth and partially bonding the cloth and controlling the bonding area, the bonding area is determined by the type of the material used, the basis weight, and the like. Since it greatly varies depending on the fabric forming method and the like, it is desirable to control the support with moisture permeability.

The thickness of the support greatly varies depending on the use, the support and the type of the pressure-sensitive adhesive layer, and is not particularly limited.
It is preferable to be in the range of about 0 to 500 g / m ² .

When the thickness of the support is less than 50 g / m ^{2 in} terms of basis weight, necessary mechanical strength cannot be obtained, and it may be difficult to make the thickness uniform, which is preferable. Absent.

On the other hand, if the thickness of the support exceeds 500 g / m ² , the flexibility is reduced, the conformability to the body surface is significantly reduced, and the followability to deformation and movement of the body surface is reduced. However, it is not preferable because it makes the hand feel stiff.

Thus, in particular, the thickness of the support is preferably in the range from 80 to 250 g / m ² , particularly preferably 100 g / m ^2.
It is desirable to be within the range of 200 g / m ² , and within this range, the required mechanical strength and flexibility can be obtained.

In the present invention, various pressure-sensitive adhesive layers are formed on one side of the support, but the pressure-sensitive adhesive is not particularly limited as long as it contains water. In the present invention, a hydrophilic pressure-sensitive adhesive, such as a poultice or a cooling / heating sheet, which has a medicinal effect, a cooling effect, and a poultice effect over a long period of time due to evaporation of moisture is preferred.

Specific examples include hydrophilic acrylic polymer-based adhesives such as polyacrylic acid-based adhesives, polyvinyl acetal-based adhesives, polyvinyl alcohol-based adhesives, cellulose-based adhesives, and vinyl acetate-based adhesives. Can be

The thickness of the pressure-sensitive adhesive layer varies depending on the use of the external patch and is not particularly limited, but is generally in the range of 300 to 4,000 μm, and particularly preferably in the range of 1.0 to 1.0.
When the thickness of the pressure-sensitive adhesive layer is less than 300 μm, required moisture and skin adhesion may not be obtained.
If it exceeds μm, not only is it bulky and the usability deteriorates,
It is not preferable because economic efficiency is deteriorated.

The above-mentioned pressure-sensitive adhesive contains various kinds of drugs depending on the use. The drugs are not particularly limited. Specifically, for example, corticosteroids, anti-inflammatory analgesics, hypertensives , Anesthetics, hypnotics, tranquilizers, antihypertensives, antibiotics, antibacterials, vitamins,
Examples thereof include an antiepileptic agent, a coronary vasodilator, an antihistamine, and an antifungal substance. In the present invention, it is particularly preferable that the pressure-sensitive adhesive layer contains a poultice that exhibits a poultice effect.

That is, in the present invention, as the pressure-sensitive adhesive,
It is desirable to use one containing a poultice, a cooling agent, etc. used for a compress or a cooling / heating sheet.

Specifically, the cooling / heating sheet may contain only water, but is not limited to only water, and may be sublimable crystals, peppermint oil, eucalyptus oil, or the like.
Lavender oil, paraben, etc. are added as needed.

In poultices, 2% boric acid aqueous solution, physiological saline, bitumen, alcoholic water, linseed oil, lime water, liver oil, olive oil, rivanol water, permanganate, which are generally used as poultices, are used. Potassium acid (5,000-fold dilution) solution, mentor water, creosote, mustard, and the like are used.

In the present invention, it is essential that the pressure-sensitive adhesive layer contains water. The water content is in the range of 50 to 90% by weight based on the whole pressure-sensitive adhesive layer. It is preferably in the range of 55 to 80% by weight, particularly preferably in the range of 60 to 75% by weight.

However, in the present invention, the pressure-sensitive adhesive layer contains water exhibiting a cooling effect, and the excellent cooling effect, antipyretic effect and cooling effect are maintained over a long period of time by utilizing the heat absorption and latent heat of evaporation of the water. Is desirable.

In the present invention, as described above, it is desirable that the pressure-sensitive adhesive layer contains a poultice that exhibits a compressing effect, since it exhibits an extremely excellent compressing effect. The foregoing are mentioned.

[0061]

The first external patch of the present invention has the above constitution, and as a support, a cloth and a cloth are laminated and partially adhered, and by controlling the adhesion area, a moisture permeability of 2,80 is obtained.
And using a range of 0~4,400g / m 2 ^· 24hr, deterioration of appearance component in the adhesive layer is due to seep to the outside of the support, the function of preventing the clothes fouling It has.

In particular, when the moisture permeability of the support is 2,
By adjusting the range of 800~4,400g ^/ m 2 · 24hr, performs loading of moisture of the support, and water in the pressure-sensitive adhesive layer, prevent the volatile component (e.g., a volatile drug) to transpiration In addition to maintaining the cooling effect or compressing effect over a long period of time, it also suppresses the occurrence of stuffiness, rash, itching, red spots and skin irritation, and improves the usability, safety and hygiene. It has.

The support used in the present invention is formed by laminating and partially adhering cloths to each other.
This material has a good texture, and, as a result of the support being formed with a cloth, an anchoring effect between the support and the pressure-sensitive adhesive layer is exhibited, and there is no cohesive failure when the external patch is peeled from the outer skin, It has the effect of preventing adhesive residue from remaining on the outer skin and improving the appearance and feel during use and the commercial value.

In the first patch for external use of the present invention, the above-mentioned support carries 20 to 400% by weight of water of its own weight before laminating the pressure-sensitive adhesive layer. With this configuration, the affinity between the water-containing pressure-sensitive adhesive layer and the support is improved, and the adhesion between the two is enhanced.

Further, in the second external patch of the present invention, there is provided a skin-adhesive type patch comprising a film-like or sheet-like support and a water-containing adhesive layer laminated on one side thereof. The support has a moisture permeability of 2,800 to 4,4.
Is formed in a distribution in the range of 00g ^/ m 2 · 24hr,
In addition, this support is characterized in that moisture is supported on the support before laminating the pressure-sensitive adhesive layer by 20 to 400% by weight of the support's own weight. Has the same action as the first external patch of the present invention by having such a configuration.

[0066]

The present invention will be described below in detail with reference to examples, but the present invention is not limited to these examples.

FIG. 1 is a sectional view of an external patch according to the present invention, and FIG. 2 is a sectional view of another external patch according to the present invention.

In FIG. 1, an external patch 1 according to the present invention is shown.
Is composed of a film-shaped or sheet-shaped support 2 and a water-containing pressure-sensitive adhesive layer 3 laminated on one side thereof. This support 2 is formed by laminating a cloth 2a and a cloth 2b to form a heat-sensitive adhesive. (Hot-melt) layer 2c is partially adhered and by controlling the adhesion area, the moisture permeability is 2,800.
４，4,400 g / m ² · 24 hr, and furthermore, before laminating the pressure-sensitive adhesive layer 3, the support 2 is filled with water W by 20-400% by weight of its own weight. It is carried.

Further, in the external patch 1 according to the present invention, the cloth 2a and the cloth 2
Instead of partially bonding b and b, as shown in FIG. 2, the heat-fusible cloth 2a and the cloth 2b are partially bonded by a heat seal 2c and the bonding area is controlled. moisture permeability 2,800~4,400g ^/ m 2 · 24
It may be formed so as to fall within the range of hr.

Further, in another external patch 1 according to the present invention, a cloth 2a and a cloth 2b are laminated and partially adhered by a layer 2c of a heat-sensitive adhesive (hot melt), and the adhesion area is controlled. By doing, the moisture permeability is 2,800-4,
Instead of using a support body 2 is formed in a range of 400g ^/ m 2 · 24hr, moisture permeability is formed by distribution in the range of 2,800~4,400g ^/ m 2 · 24hr as a support 2 Further, before the water-containing pressure-sensitive adhesive layer 3 is laminated, the support 2 carries 20 to 400% by weight of water W based on the weight of the support 2.

The cloths 2a and 2b used in the present invention are not particularly limited, and include, for example, non-woven fabrics, woven fabrics and knitted fabrics. , Non-woven and knitting,
It is formed by laminating and partially adhering woven fabric and knitted fabric or knitted fabric and knitted fabric.

Further, in the present invention, the partial bonding between the cloth 2a and the cloth 2b may be performed by an adhesive instead of the heat bonding or the heat welding as described above.

The support 2 used in the present invention is not particularly limited in laminating and partially adhering the cloth 2a and the cloth 2b, but the cloth 2a and the cloth 2b are, for example, as shown in FIG. As shown in FIG. 4, partial bonding may be performed in a lattice shape, as shown in FIG. 4, partial bonding may be performed in an oblique stripe shape, and as shown in FIG. 6, may be partially adhered in a wavy form as shown in FIG. 6, may be partially adhered in a stripe form as shown in FIG. 7, and may be partially adhered in an oblique lattice form as shown in FIG. You can do it.

In FIGS. 3 to 8, each support 2 carries 20 to 400% by weight of water W on its own weight before laminating the pressure-sensitive adhesive layer 3 containing water. It becomes.

By the way, the pressure-sensitive adhesive layer 3 is not particularly limited as long as it contains water. In the present invention, in particular, in the present invention, the medicinal effect and the like are obtained by evaporating the water like a poultice or a cooling / heating sheet. A hydrophilic pressure-sensitive adhesive which has a cooling effect and a compressing effect for a long time is preferable.

The thickness of the pressure-sensitive adhesive layer 3 varies depending on the use of the external patch 1, and is not particularly limited, but is generally adjusted in the range of 300 to 4,000 μm.

Incidentally, the pressure-sensitive adhesive layer 3 is required to contain water as an essential requirement. The water content is in the range of 50 to 90% by weight based on the whole pressure-sensitive adhesive layer 3.
It is preferably in the range of 55 to 80% by weight, particularly preferably 6 to 80% by weight.
It is desirable to set it in the range of 0 to 75% by weight.

The pressure-sensitive adhesive layer 3 contains water exhibiting a cooling effect, and an excellent cooling effect, antipyretic effect and cooling effect are maintained over a long period of time by utilizing the heat absorption and latent heat of evaporation of the water. .

Further, in the present invention, as described above,
It is desirable that the pressure-sensitive adhesive layer 3 contains a poultice that exhibits a poultice effect because it exhibits an extremely excellent poultice effect.
Examples of the poultice include those described above.

As shown in FIG. 9, the external patch 1 according to the present invention is used, for example, as a fever relieving sheet when fever occurs due to a disease.

Production of the Support Used in the Present Invention In the following, in forming the support 2, the following two fabrics 2a and 2b are used, respectively.
Was partially formed by hot bonding using hot melt. In this case, the ratio of the hot melt is 60 g /
It was adjusted to m ^2.

Cloth (outer surface side) 2a As a cloth, a non-woven fabric (spunlace) manufactured by Kuraray Co., Ltd.
Polyester 100% basis weight 70 g / m ² ) was used.

Cloth (skin side) 2b Non-woven fabric (melt blown product) manufactured by Kuraray Co., Ltd.
Polypropylene 100% basis weight 50 g / m ² ) was used.

Support 2 The cloth 2a and the cloth 2b are overlapped and partially adhered by thermal adhesion using hot melt to give a moisture permeability of 2,580 g /
m ² · 24hr (adhesive polka shape so that the adhesive area is non-adhesive area is about 10% to about 90%, Figure 5), 3,6
50g ^/ m 2 · 24hr (adhesive stripes shape so that the adhesive area is non-adhesive area is about 30% to about 70%, Fig. 4) and 4,460g ^/ m 2 · 24hr (adhesion area of about 10%
The three types of supports 2 shown in FIG. 3) were manufactured in such a manner that the non-adhered area was approximately 90%.

In the support 2 thus manufactured, the water from the pressure-sensitive adhesive layer 3 containing water described below
It evaporates from the non-adhesive surface between the cloth 2a and the cloth 2b, removes latent heat of vaporization from the skin surface of the application portion, and cools the skin surface.

The support 2 thus obtained was cut into a rectangle having a length of 50 mm and a width of 140 mm, and was found to have a moisture permeability of 2,580 g / m ² · 24 hr (Comparative Example 1), 3,65
0g ^/ m 2 · 24hr (Example 1) and 4,460G /
to obtain a support of m ² · 24 hr or (Comparative Example 2).

Before laminating the pressure-sensitive adhesive layer 3 containing water, the support 2 is sprayed with water W by 125% by weight of its own weight.
It is carried.

Example 1 14.0 parts by weight of glycerin, 6.2 parts by weight of sodium polyacrylate, 3.0 parts by weight of polyvinyl alcohol, 0.5 parts by weight of carboxyvinyl polymer, 0.15 parts by weight of l-menthol and water 68 parts by weight, and further added 0.06 part by weight of metasilicic acid / magnesium aluminate (trade name: Neusilin manufactured by Fuji Chemical Industry Co., Ltd.) and 0.04 part by weight of aluminum hydroxide gel to form an adhesive layer 3 which was
Said support 2 (moisture permeability 3,650g ^/ m 2 · 24h
r, applied to one side of 50 mm in length and 140 mm in width) to a thickness of 3,200 μm and aged to obtain an external patch (cooling / heating sheet) of the present invention.

Example 2 Instead of the support used in Example 1, the moisture permeability was 3,320.
except for using a support consisting of g ^/ m 2 · 24hr fabric (nonwoven) Shandong Laizhou non woven fabric Ltd. Ltd. (trade name spunbonded polypropylene 100% basis weight of 150 g / ^{m 2),} similarly as in Example 1 Thus, an external patch (cooling / heating sheet) was obtained.

That is, before laminating the pressure-sensitive adhesive layer 3 containing water, the support 2 is sprayed with water W by spraying the support 2 with 125% by weight of its own weight.
It is carried.

Comparative Example 1 Instead of the support used in Example 1, the moisture permeability was 2,580.
except for using the support of g ^/ m 2 · 24hr, the Example 1
In the same manner as described above, an external patch (cooling / heating sheet) was obtained.

Comparative Example 2 Instead of the support used in Example 1, the moisture permeability was 4,460.
except for using the support of g ^/ m 2 · 24hr, the Example 1
In the same manner as described above, an external patch (cooling / heating sheet) was obtained.

Comparative Example 3 A commercially available product of Company A was used.

Comparative Example 4 Commercially available products from three companies were used.

Using the cooling sheets obtained in Examples 1 and 2 and Comparative Examples 1 to 4, the cooling temperature characteristics were measured by the following method.

Cooling temperature The ambient temperature was maintained at 19 ° C. to 21 ° C., and the shipping surface of each of Examples 1 and 2 and Comparative Examples 1 to 4 was attached to a polypropylene plate of a tester. 2
The temperature of the central ship surface of each of Comparative Examples 1 to 4 was measured.

Tester The tester consists of a heater and a circulating constant temperature water tank, and its structure and dimensions are as follows. 1. Heater a) The material of the heater is SUS 304 of JIS G 4303 (hot-rolled stainless steel plate) and has a thickness of 3 mm.
mm, 300 mm long, 600 mm wide, and 100 mm wide. b) The heating part surface of the heater is 6 mm thick and 300 m long
A single plate of a polyacrylic resin plate having a width of 600 mm and a width of 600 mm is fixed on the above-mentioned a) with screws and covered. c) A part other than the surface of the heating part is covered with a styrene foam insulating material having a thickness of 30 mm. 2. Circulating constant-temperature water tank The circulating constant-temperature water tank is capable of circulating hot water at a flow rate of 19 to 21 liters / minute through a heater. In this case, the temperature on the polyacryl plate covering the surface of the heating unit is 35. Water temperature was adjusted to maintain ~ 37 ° C.

The results of the cooling temperature characteristics thus measured are shown in Table 1 and FIGS. By the way, in Table 1, the temperature at the start refers to the temperature at the start of use of the cold / hot sheet.

[0099]

[Table 1]

By the way, in general, when a person applies a cooling / heating sheet to the outer skin of a forehead or the like and feels cold, it is more important for the skin temperature to be 1.
Although it is necessary that there is a temperature difference of 5 ° C. or more, the results shown in Table 1 and FIGS. 10 and 11 show that the cooling effects of Examples 1 and 2 are about 9 to 10.5 hours, respectively. On the other hand, in the case of Comparative Example 1, the cooling effect was maintained only for about 3 to 4 hours, and in the case of Comparative Example 2, the cooling effect was 4 hours.
It is recognized that it lasts only about an hour.

It is also recognized that Comparative Example 3 (product of Company A) has a cooling effect of 5 to 6 hours, and that of Comparative Example 4 (Product of Company B) lasts for about 4 hours.

From the above results, those of Examples 1 and 2
It is confirmed that the cooling effect is almost twice or more longer than that of Comparative Examples 1 to 4, and it is recognized that the cooling effect for a long time can be obtained.

[0103]

The first external patch of the present invention has the above constitution, and as a support, a cloth and a cloth are laminated and partially adhered, and the adhesive area is controlled so that the moisture permeability is 2,2. and using a range of 800~4,400g / m 2 ^· 24hr, preventing deterioration of the appearance component in the adhesive layer is due to seep to the outside of the support, the clothing soiling It has the effect that can be done.

Further, in particular, the moisture permeability of the support is set to 2,80.
By adjusting the range of 0~4,400g / m 2 ^· 24hr, moisture and volatile components in the adhesive layer (e.g., a volatile drug) controls that transpired, extremely long cooling effect and poultices effect In addition to being sustained and manifested over time, it has the effects of preventing the occurrence of stuffiness, rash, itching, red spots and the like and the occurrence of skin irritation, improving the feeling of use, and having extremely excellent safety and hygiene.

Further, the support used in the first external patch of the present invention is formed by laminating and partially adhering a cloth to a cloth, which has good texture and moisture retention. In addition, as a result of the support being formed by the cloth, an anchoring effect between the support and the adhesive layer is exhibited, and there is no cohesive failure when the external patch is peeled from the outer skin, and glue remains on the outer skin. Not only that, it also has the effect of improving the appearance and feel during use and the commercial value extremely.

In the first patch for external use of the present invention, the above-mentioned support carries 20 to 400% by weight of water of its own weight before laminating the pressure-sensitive adhesive layer, With this configuration, the affinity between the water-containing pressure-sensitive adhesive layer and the support is improved, and the adhesion between the two is increased. This has the effect of improving the shape retention of the pressure-sensitive adhesive layer, increasing the cooling effect, and prolonging the cooling duration.

In other words, various components are used for the water-containing pressure-sensitive adhesive layer according to the intended use. In this case, depending on the type and composition of the components, a sufficient shape-retaining property cannot be obtained. However, at this time, the amount of water is reduced to secure the shape retention property, and on the other hand, in order to obtain a required cooling effect and cooling time, there is an effect that the water carried on the support can be utilized. It is.

The second external patch of the present invention has the above-mentioned constitution, and has a moisture permeability of 2,800 to 4,400 g as a support.
/ M is used in the range of 2 ^· 24 hr or, worse appearance component in the adhesive layer is due to seep to the outside of the support, because it has an advantage of being able to prevent the garment fouling is there.

Further, in particular, the moisture permeability of the support is set to 2,80.
By adjusting the range of 0~4,400g / m 2 ^· 24hr, moisture and volatile components in the adhesive layer (e.g., a volatile drug) controls that transpired, extremely long cooling effect and poultices effect In addition to being sustained and manifested over time, it has the effects of preventing the occurrence of stuffiness, rash, itching, red spots and the like and the occurrence of skin irritation, improving the feeling of use, and having extremely excellent safety and hygiene.

Further, the support used in the second external patch of the present invention is formed of a cloth, which has good texture and moisture retention, and is formed of a cloth. As a result, an anchoring effect between the support and the pressure-sensitive adhesive layer is exerted, no cohesive failure occurs when the external patch is peeled from the outer skin, no adhesive residue remains on the outer skin, and the appearance and feeling during use and the product The effect is that the value is extremely improved.

[0111] In the second external patch of the present invention, before the adhesive layer is laminated, moisture is carried on the above-mentioned support at 20 to 400% by weight of its own weight. With this configuration, the affinity between the water-containing pressure-sensitive adhesive layer and the support is improved, and the adhesion between the two is increased. This has the effect of improving the shape retention of the pressure-sensitive adhesive layer, increasing the cooling effect, and prolonging the cooling duration.

In other words, various components are used for the water-containing pressure-sensitive adhesive layer according to the intended use. In this case, depending on the type and composition of the components, a sufficient shape-retaining property cannot be obtained. However, at this time, the amount of water is reduced to secure the shape retention property, and on the other hand, in order to obtain a required cooling effect and cooling time, there is an effect that the water carried on the support can be utilized. It is.

[Brief description of the drawings]

FIG. 1 is a sectional view of an external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 2 is a cross-sectional view of another external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 3 is a partially peeled and cutaway perspective view of another external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 4 is a partially peeled and cutaway perspective view of another external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 5 is a partially peeled, cutaway perspective view of another external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 6 is a partially peeled, cutaway perspective view of another external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 7 is a partially peeled and cutaway perspective view of another external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 8 is a partially peeled and cutaway perspective view of another external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 9 is an explanatory diagram showing a use state of the external patch (cooling / heating sheet) according to the first aspect of the present invention.

FIG. 10 is a temperature characteristic diagram of each cooling / heating sheet and blank.

FIG. 11 is a temperature characteristic diagram of each cooling / heating sheet and blank.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 External patch 2 Support 2a Cloth 2b Cloth 2c Adhesive layer 3 Adhesive layer

 ────────────────────────────────────────────────── ─── Continued on the front page F term (reference) 4C099 AA02 CA04 CA19 EA05 GA01 GA02 HA09 LA02 LA04 LA05 LA08 LA14 LA15 4J004 AA04 AA08 AA09 AA10 AB01 CA02 CA04 CA05 CA06 CB01 CC03 CC08 CE01 DB02 EA04 FA09

Claims (7)

[Claims] 1. A skin-adhesive patch in which a film-like or sheet-like support is laminated on one side with a water-containing pressure-sensitive adhesive layer, wherein the support is a laminate of cloth and cloth. By partially bonding and controlling the bonding area, the moisture permeability is 2,800 to 4,400 g / m ^2.
It is formed in a range of 24 hours, and furthermore, before laminating the pressure-sensitive adhesive layer, the support carries moisture at 20 to 400% by weight of its own weight. External patch. 2. The external patch according to claim 1, wherein the water content in the pressure-sensitive adhesive layer is in the range of 50 to 90% by weight based on the whole pressure-sensitive adhesive layer. 3. The external patch according to claim 1, wherein the cloth is a non-woven fabric, a woven fabric, or a knitted fabric. 4. The support according to claim 1, wherein the support is formed by laminating and partially bonding a nonwoven fabric and a nonwoven fabric, a nonwoven fabric and a woven fabric, a nonwoven fabric and a knitted fabric, a woven fabric and a knitted fabric, or a knitted fabric and a knitted fabric. Or the external patch according to item 1. 5. The external patch according to claim 1, wherein the partial adhesion between the cloth and the cloth is performed by adhesion, heat bonding, or heat welding. 6. A skin-adhesive patch comprising a film-like or sheet-like support and a water-containing pressure-sensitive adhesive layer laminated on one side thereof, wherein the support has a moisture permeability of 2,800.支持 4,400 g / m ² · 24 hr, and the support is filled with moisture before laminating the pressure-sensitive adhesive layer.
An external patch characterized by being loaded with 00% by weight. 7. The external patch according to claim 1, wherein the pressure-sensitive adhesive layer contains a poultice exhibiting a poultice effect.