JP2001247439A - Composite dentifrice - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composite dentifrice having high caries preventing effect and tooth bleaching effect and containing a dentifrice component composed mainly of a fluorine compound as an active component and a dentifrice component composed mainly of a tricalcium phosphate compound as an active component in a manner separated from each other to prevent the reaction and combined with each other in use. SOLUTION: The objective composite dentifrice is composed of a 1st dentifrice component 3 containing tricalcium phosphate as a main active component, a 2nd dentifrice component 4 containing a fluorine compound as a main active component and a vessel 1 having plural containers to hold the above two components in separated state and a discharging port to discharge the above two dentifrice components.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a composite dentifrice comprising a combination of a fluorine compound and tricalcium phosphate. More particularly, the present invention relates to a composite dentifrice improved such that the superior activity of the fluorine compound and the superior activity of tricalcium phosphate act effectively on the teeth during the brushing operation.

[0002]

2. Description of the Related Art Toothpastes are available in powder, paste, and liquid forms. They consist mainly of abrasives, wetting agents, and water, and contain small amounts of foaming agents, binders, flavors, and coloring agents. And preservatives are included. Attempts have been made to improve the properties of this dentifrice component by adding additional components having various medicinal properties to the toothpaste component, and some of them have already been manufactured and sold as commercial products.

A typical example of the above additive component is a fluorine compound. It has been confirmed that this fluorine compound is partially dissociated in water or saliva as a fluorine ion, and the fluorine ion reacts with the surface layer of the tooth to increase the surface hardness of the tooth.

In recent years, it has been studied to add a calcium phosphate compound called hydroxyapatite, which has a mineral name close to the components of teeth, to a dentifrice.
JP-A-56-73014, JP-A-56-73001
No. 5, No. 60-206678, No. 61-91
No. 333, 57-185213 and the like. That is, since hydroxyapatite has the same chemical composition as teeth, it has a high affinity for teeth and can fill in missing parts of teeth formed by tooth decay. This dentifrice to which hydroxyapatite is added is actually manufactured and sold as a commercial product. on the other hand,
The same calcium phosphate compound, the mineral name witlocite, whose solubility is greater than hydroxyapatite,
It has been widely known for a long time that tricalcium phosphate is commonly used as an abrasive component of a dentifrice. Japanese Patent Application No. 3
No. 7-265559 (Japanese Patent Application No. 40-1552)
No. 0).

[0005] As described above, the fluorine compound and the hydroxyapatite are added to the dentifrice, respectively,
Conventionally, studies have been made to use both of them in order to provide excellent effects in preventing caries. JP 1
No. 6213 (corresponding to Japanese Patent Publication No. 2-31049)
And publications such as JP-A-10-265559.

[0006]

However, if the fluorine compound and hydroxyapatite are simultaneously added to one dentifrice so as to be mixed together, there is a possibility that both of them will react in an unused dentifrice, and as a result, The effect of increasing the surface hardness of the teeth of fluorine ions released from the fluorine compound and the effect of adsorbing hydroxyapatite are reduced. If each container is filled with the dentifrice, the user becomes inconvenient. In addition, in order to enhance the effect of preventing tooth decay, it is desirable to add a fluorine compound having a strong activity as much as possible. There was also a problem that both of them reacted.

Therefore, an object of the present invention is to solve the above-mentioned problems. That is, according to the present invention, when not used, a dentifrice containing a fluorine compound as a main component and a dentifrice containing a calcium phosphate compound as a main component are isolated from each other so that no reaction occurs between the two. An object of the present invention is to provide a composite dentifrice having a high tooth whitening effect and prevention of tooth decay taken out.

[0008]

According to the present invention, there is provided a dentifrice product comprising a first dentifrice component containing tricalcium phosphate as a main component and a second dentifrice component containing a fluorine compound as a main component. A dentifrice component, and an integrated container having a plurality of storage chambers for separately containing the two dentifrice components and an outlet for removing the two stored dentifrice components. It is characterized by the following.

Here, the content of tricalcium phosphate is as follows:
It may be in the range of 0.1 to 20% by weight based on the total amount of the first dentifrice component mainly containing tricalcium phosphate and the second dentifrice component mainly containing a fluorine compound. preferable. Also, the content of the fluorine compound is phosphoric acid 3
A range of 0.002 to 5.0% by weight in terms of the amount of fluorine ions with respect to the total amount of the first dentifrice component containing calcium as a main component and the second dentifrice component containing a fluorine compound as a main component. Is preferred.

[0010] In a preferred embodiment of the present invention, a simple one partition plate is provided to divide the container into two, and
And a second dentifrice component. Further, as another embodiment, two containers having different concentric sizes are integrated, and one of the dentifrice components is placed inside the inner container, and the inside of the outer container and the outside of the inner container are combined. Put the other dentifrice ingredient in the space between
The inner container serves as a partition.

Further, the dentifrice product of the present invention comprises phosphoric acid 3
A first dentifrice component containing calcium as a main component, a second dentifrice component containing a fluorine compound as a main component,
A composite dentifrice comprising: a plurality of storage chambers for separately containing two dentifrice components; and an integrated container having an outlet for removing the two stored dentifrice components, wherein the integrated dentifrice comprises: A mechanism is provided in which the second dentifrice component is taken out of the container by being encapsulated in the first dentifrice component, or the second dentifrice component is taken out after the first dentifrice component. I do.

According to a preferred embodiment of the present invention, in the above-mentioned container in which two concentric containers having different sizes are integrated, the outlet of the inner container is set at a position lower than the outlet of the outer container. It is.

[0013] In another embodiment, a valve is provided which causes a time difference when the toothpaste component is opened at the outlet, and the second dentifrice component containing a fluorine compound as a main component contains tricalcium phosphate. It has a mechanism to be taken out later than the first dentifrice component as the main component.

[0014]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The complex dentifrice of the present invention will be described in detail with reference to the drawings.

FIG. 1 shows a composite dentifrice according to one embodiment of the present invention. The composite dentifrice container 1 is an integrated container provided with two storage chambers by a partition plate 2. One of the storage compartments contains a dentifrice component 3 containing tricalcium phosphate as a main active ingredient, and the other contains a dentifrice component 4 containing a fluorine compound as a main active component.
Is accommodated. At the time of use, both dentifrice components 3, 4 are simultaneously taken out from the take-out opening. As described above, since the dentifrice components 3 and 4 are stored separately when not in use, no reaction occurs in the container. In addition, since both toothpaste components 3 and 4 are taken out at the same time during use, each toothpaste component effectively acts on the tooth.

FIG. 2 shows a composite dentifrice according to another embodiment. The composite dentifrice container 1 is composed of large and small concentric containers having different diameters, and has a configuration in which an inner container 7 is built in an outer container 6. A dentifrice component 4 containing a fluorine compound as a main active ingredient is contained in the inner container 7, and tribasic calcium phosphate as a main active ingredient is contained in a storage space surrounded by an inner wall of the outer container 6 and an outer wall of the inner container 7. Toothpaste ingredient 3
Is accommodated. Here, the inner container 7 plays the same role as the partition 2.

FIG. 3 shows a composite dentifrice according to yet another embodiment. This composite dentifrice container 1 is also composed of large and small concentric containers having different diameters, as shown in FIG.
The inner container 7 is provided inside the outer container 6. The difference from the container of FIG. 2 is the portion of the outlet. The outlet of the inner container 7 is at a lower position than the outlet of the outer container 6. For this reason, in this container, first, the dentifrice component 3 containing tricalcium phosphate as a main active ingredient is taken out of the take-out opening, and the dentifrice component 4 containing a fluorine compound as a main active ingredient is taken out later. become.

When the dentifrice component 3 containing tricalcium phosphate as a main component is taken out first, a large amount of phosphate ions and calcium ions are generated in saliva, and both ions are easily adsorbed to the teeth, and the surface of the tooth surface This has the effect of facilitating the deposition of fluoroapatite.

Although not shown in the drawing, another embodiment for changing the time for taking out each dentifrice component as in the example of FIG. 3 is to provide a valve provided with a time difference when opening the take-out opening. . For example, the valve for the dentifrice component 3 to be taken out early has a mechanism that opens as soon as the container is tilted, and the valve for the dentifrice component 4 that needs to be taken out late has a mechanism that does not open unless the container is turned upside down.

Next, the materials constituting the dentifrice product of the present invention will be described below. 1. Toothpaste component containing tricalcium phosphate as the main active ingredient Tricalcium phosphate When the reaction between tricalcium phosphate and a fluorine compound was studied, tricalcium phosphate did not directly react with fluorine ions, and the solubility was high. Calcium and phosphate ions dissociated from tricalcium phosphate ions, and fluorine ions dissociated from fluorine compounds, and calcium and phosphate ions in saliva react with each other on the tooth surface to form new fluorapatite on the tooth surface. Was found to precipitate.

Conventionally, it is known that saliva contains a large amount of calcium and phosphate ions and prevents teeth from being dissolved by carbonated beverages or water. That is, even if the tooth is slightly melted, the calcium and phosphate ions in saliva precipitate hydroxyapatite constituting the tooth again. (Caries Control, Mechanisms of Demineralization and Remineralization, Yoichi Iijima, Kumagaya, Medical and Dental Medicine Publishing, 199
8). The present invention utilizes the effect of saliva synergistically.

That is, it has been found that tricalcium phosphate, which has been widely used as an abrasive, reacts with fluoride ions and calcium in saliva with phosphate ions to precipitate fluorapatite. It is considered that the generated fluorapatite is adsorbed to the teeth, so that the whitening effect of the teeth and the effect of preventing tooth decay can be obtained.

The tricalcium phosphate-containing dentifrice component comprises:
Tricalcium phosphate can be produced as a polishing agent by a known conventional method. Tricalcium phosphate has α-form,
There are β type and amorphous γ type. Solubility is α-type phosphoric acid 3
Calcium is the largest, followed by β-type and γ-type. Form γ contains a small amount of water and the crystal structure has not been elucidated. Recently, the well-known amorphous calcium phosphate ACP (amorphous calciu)
m phosphate) is said to have a composition of tricalcium phosphate. The tricalcium phosphate in the composite dentifrice component of the present invention is preferably β-type, γ-type or ACP rather than unstable α-type. The particle diameter of tricalcium phosphate is preferably 10 μm or less, and particularly preferably in the range of 0.01 to 3 μm. 2. Toothpaste component containing fluorine compound as main active ingredient Fluorine compound Fluorine-containing dentifrice has already spread all over the world and contains fluorine compound which dissolves in water or saliva to release fluoride ions as main active ingredient Things. As an example of the fluorine compound, sodium monofluorophosphate, which is currently most commonly used, can be used in the present invention. However, in the present invention, it is preferable to use a fluorine compound having a stronger activity such as sodium fluoride. This is because the use of a highly active fluorine compound has a stronger effect on teeth. In a conventional dentifrice, since a fluorine compound and a polishing agent such as calcium hydrogen phosphate dihydrate and hydroxyapatite are mixed in one container, when a fluorine compound having a strong activity is used, both react. Although it is possible, in the composite dentifrice of the present invention, the tricalcium phosphate and the fluorine compound are surely isolated when not used, so that there is no problem that both react. Therefore, the activity of each active ingredient is high,
Compared to conventional dentifrices containing a mixture of a calcium phosphate compound and a fluorine compound, the caries preventive action and tooth whitening action are enhanced. In addition, the reaction between tricalcium phosphate and fluorine ions is milder and safer than the conventional reaction between hydroxyapatite and fluorine ions.

There have been known many examples of the composition of the fluorine-containing dentifrice component itself, including the types and amounts of subcomponents and additional components, and the fluorine-containing dentifrice used in the present invention has been known. Can be produced by appropriately utilizing those known materials and known compounding techniques. 3. Container The container for the composite dentifrice of the present invention is not particularly limited. Any form and any material can be used as long as it has the structure specified in the present invention.

[0025]

【Example】

Example 1 (1) Preparation of a dentifrice component containing a fluorine compound as a main active ingredient The following components were kneaded by a conventional method to obtain a fluorine-containing dentifrice paste. Calcium hydrogen phosphate dihydrate 30 wt% Aluminum hydroxide 5 wt% Glycerin 15 wt% Sorbitol 15 wt% Carboxymethylcellulose 2 wt% Sodium lauryl sulfate 1 wt% Sodium fluoride 0.5 wt% Fragrance 1 wt% Purified water 30 (2) Preparation of dentifrice component containing tricalcium phosphate as a main active ingredient The following components were kneaded by a conventional method to obtain a tricalcium phosphate-containing dentifrice paste. Tricalcium phosphate 15% by weight Calcium hydrogen phosphate anhydrous 20% by weight Glycerin 10% by weight Sorbitol 10% by weight Sodium lauryl sulfate 1% by weight Saccharin sodium 0.1% by weight Fragrance 1% by weight Purified water 42.9% by weight (3) Tube-containing composite toothpaste The fluorine-containing toothpaste and the tricalcium phosphate-containing toothpaste prepared above were respectively added to the inner space and the outer space of the double-tube type toothpaste tube shown in FIG. Thus, the dentifrice product of the present invention was obtained. (4) Confirmation of formation reaction of fluorapatite The composite dentifrice prepared in (3) was used for 10 times as in use.
Take out into 0cc beaker and stir. As a result of immediately analyzing the mixture of the fluorine-containing toothpaste and the tricalcium phosphate-containing toothpaste by powder X-ray analysis,
The diffraction peak of tricalcium phosphate slightly decreased, and a diffraction peak of apatite was newly observed. The apatite was separated by the heavy liquid method and analyzed by infrared absorption spectrum. As a result, it was confirmed that the apatite was fluoroapatite. From this, it was revealed that tricalcium phosphate in the composite toothpaste reacts with sodium fluoride to newly generate fluorapatite. (5) Evaluation of composite toothpaste ・ Evaluation test for improvement in whiteness Fifteen adult male and female subjects were divided into three groups of five each, and each subject in each group was treated with the following toothpaste for 3 days a day. 1 hour (3 minutes each time), one week of tooth brushing work was performed, and after one week later, the whiteness of the left and right upper maxillary teeth was measured using a colorimeter equipped with a fiberscope.

Group A: Toothpaste of the present invention prepared in (3) above Group B: Toothpaste containing tricalcium phosphate (commercially available) Group C: Toothpaste containing fluoride (commercially available) Evaluation result Test result Is shown in the table below using numerical values of whiteness. still,
The whiteness was represented by the average value ± standard deviation.

[0027]

[Table 1]

* Reference value: Whiteness of standard white plate 97 ± 1 It can be seen that the tooth whiteness is significantly improved when toothpaste is performed using the composite toothpaste product of the present invention.・ Evaluation test on safety Eighteen subjects, girls aged 20 to 23, were divided into three groups of six, and each subject in each group was brushed three times a day using the following toothpaste (for three minutes each time). , 1
After one month of brushing work, one month later, the work was visually observed for oral mucosa, lip allergy and periodontal disease.

Group A: The composite toothpaste of the present invention produced in (3) above Group B: Toothpaste containing tricalcium phosphate (commercially available) Group C: Toothpaste containing fluoride (commercially available) ・ Evaluation results All No abnormalities were observed and safety was confirmed.

[0030]

Example 2 (1) Preparation of a liquid dentifrice component containing a fluorine compound as a main active ingredient The following components were kneaded by a conventional method to obtain a liquid fluorine-containing dentifrice component. Calcium hydrogen phosphate dihydrate 1% by weight Glycerin 5% by weight Sorbitol 3% by weight Sodium lauryl sulfate 1% by weight Sodium fluoride 0.1% by weight Fragrance 1.0% by weight Purified water 88.9% by weight (2) phosphoric acid Preparation of Liquid Toothpaste Component Having Tricalcium as Main Active Ingredient The following components were kneaded by a conventional method to obtain a liquid dentifrice component containing tricalcium phosphate. Tricalcium phosphate 1% by weight Glycerin 5% by weight Sorbitol 3% by weight Sodium lauryl sulfate 1% by weight Flavor 1% by weight Purified water 89% by weight (3) Liquid composite toothpaste in a glass bottle The liquid toothpaste of the present invention is filled with the liquid tricalcium phosphate-containing dentifrice component in the inner space and the outer space of the double-tube glass container shown in FIG. 2 at a ratio of 1: 3, respectively. An agent product was obtained. (4) Evaluation of composite liquid dentifrice The liquidity dentifrice product of (3) was also subjected to a whiteness improvement evaluation test and a safety test in the same manner as in Experiment 1. As a result, an excellent whiteness improvement effect and safety comparable to the composite toothpaste product of the present invention of Example 1 were shown.

[0031]

When the composite dentifrice of the present invention is used, a remarkably excellent improvement in tooth whiteness is obtained as compared with conventional dentifrices containing fluorine or tricalcium phosphate. . Further, it was confirmed that there was no problem in safety even when a highly active fluorine compound such as sodium fluoride was used.

The present invention has a configuration in which a dentifrice component containing a fluorine compound and a dentifrice component containing tricalcium phosphate are housed separately, so that no reaction occurs between the two when not in use, thus preventing tooth decay. Thus, it is possible to provide a composite dentifrice having a high tooth whitening effect and safe.

[Brief description of the drawings]

FIG. 1 is a sectional view and a plan view showing one embodiment of a composite dentifrice according to the present invention.

FIG. 2 is a sectional view and a plan view showing another embodiment of the composite dentifrice according to the present invention.

FIG. 3 is a cross-sectional view showing another embodiment of the composite dentifrice according to the present invention.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 Composite dentifrice container, 2 partition plate, 3 dentifrice component mainly containing tricalcium phosphate, 4 dentifrice component mainly containing fluorine compound, 5
Outlet, 6 outer container, 7 inner container.

Continued on the front page (72) Inventor Hideki Aoki 35-1 Morinosato, Kisazaki-cho, Inashiki-gun, Ibaraki F-term (reference) 4C083 AB291 AB292 AB471 AB472 CC41 EE32 EE35 EE50 FF04

Claims (2)

[Claims] 1. A dentifrice component containing tricalcium phosphate as a main active ingredient, a second dentifrice component containing a fluorine compound as a main active ingredient, and the two dentifrice components housed separately. A composite dentifrice comprising: a plurality of storage chambers; and an integrated container having a single outlet for removing two stored dentifrice components. 2. A first dentifrice component containing tricalcium phosphate as a main active ingredient, a second dentifrice component containing a fluorine compound as a main active ingredient, and the two dentifrice components housed separately. A combined dentifrice having a plurality of storage chambers and an integrated container having an outlet for removing two dentifrice components contained therein, wherein a second dentifrice component is contained within said container. A composite dentifrice product characterized in that it has a mechanism in which the dentifrice is encapsulated in the first dentifrice component and removed or the second dentifrice component is removed in lag with the first dentifrice component.