JP2001199880A - Prophylaxis for drink sickness - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a prophylactic for drink sickness that includes a sugar alcohol as an active ingredient. SOLUTION: The drink sickness can be effectively inhibited by taking the sugar alcohol according to this invention before or during drinking.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a sickness preventing agent for preventing sickness due to alcohol.

[0002]

BACKGROUND OF THE INVENTION It is a daily experience that ingesting alcoholic beverages eliminates excessive tension and reduces fatigue.
In addition, there are many advantages of consuming alcoholic beverages, such as smooth and straightforward conversation. However, on the other hand, in the case where alcoholic beverages are excessively consumed, or when the physical condition is poor, even if a small amount of alcoholic beverages are consumed, sickness and hangovers often cause discomfort such as headache and vomiting. Even without such discomfort, excessive intoxication can lead to loss of mental stability, reduced attention and judgment, and annoyance to others, as well as personal safety. Problems are likely to occur even on a computer.

[0003] Therefore, it is the best way to eliminate such adverse effects by ingesting alcoholic beverages so as not to cause excessive drunkenness, sickness and hangover.
It is actually difficult to do this,
Also, alcohol intake that causes sickness and hangover
It depends on the physical condition and mood of the day.

[0004] In order to prevent such sickness and hangover caused by alcohol, it is customary to eat lightly, drink milk, or take a gastric mucosal protective agent to avoid hunger before drinking. Although it is not effective enough, it also contains gastrointestinal drugs and drinks to eliminate discomfort after drinking, and contains aldehyde decomposition accelerators (turmeric and amino acids) for the liver that is burdened by drinking Taking hepatic detoxification nutrients is also practiced, but these are mainly for the purpose of symptomatic treatment of hangovers,
It cannot effectively prevent sickness.

[0005] Conventionally, a hangover preventive / treating agent comprising L-alanine and an artificial sweetener as main components (JP-A-2020723)
No. 2), an alcohol absorption inhibitor containing glycyl / glycine as an active ingredient (JP-A-3-12739).
Agents for lowering alcohol in the body and alcohol metabolites containing catechins as the main component (JP-A-6-263648)
However, there has been a demand for a method for keeping the time of drinking sickness from drinking and awakening from a drunken state, and more effectively preventing sickness.

[0006]

Means for Solving the Problems and Embodiments of the Invention As a result of various studies to meet the above demands, the present inventor has found that a sugar alcohol such as xylitol has a surprisingly excellent sickness prevention effect. discovered. In other words, sickness is an unpleasant symptom that occurs within a few minutes to several hours of drinking,
By taking sugar alcohols such as xylitol before or during drinking, it was found that discomfort symptoms due to sickness were alleviated, and that tipsy mood (in the classification of sickness) was maintained, and the present invention was accomplished.

Hereinafter, the present invention will be described in more detail.
The agent for preventing sickness according to the present invention contains sugar alcohol as an active ingredient.

[0008] Here, sugar alcohols include xylitol, erythritol, sorbitol, mannitol,
Examples include threitol, arabitol, ribitol, galactitol, rhamnitol, trehalose, multinit, and the like. One of these may be used alone, or two or more may be used in combination. Among them, xylitol is preferred in terms of effect.

In addition to the sugar alcohol as an active ingredient, the active ingredient for preventing sickness of the present invention includes other active ingredients such as a gastric mucosa protective agent, an aldehyde decomposition accelerator (turmeric / amino acid), and other various crude drugs ( Oyster leaf extract, oyster extract, etc.) can also be used in combination.

[0010] The agent for preventing sickness of the present invention includes tablets, granules,
Capsules, drinks (liquids) and the like can be prepared into orally administrable dosage forms. In addition to sugar alcohols, known non-toxic components corresponding to these dosage forms, for example, lactose, starch, calcium phosphate, crystalline cellulose, metasilicone It can be prepared using magnesium acid aluminate, carboxymethyl cellulose, glycerin, flavor, sweetener, vitamins and the like.

Here, the agent for preventing sickness of the present invention is used before or during alcohol use.
Is 1 to 20 per kg of adult weight as sugar alcohol
It can be in the range of 00 mg.

Since the sickness-preventing agent of the present invention contains the above-mentioned sugar alcohol as an active ingredient, it is safe to use, has no strong bitterness or off-flavor, is easy to take, and can be formulated into a formulation suitable for carrying and taking. It is easy to do.

[0013]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to the following examples.

[Example 1] Male Wistar rats were bred for 1 week and used at a body weight of 110 to 120 g. The animals were fasted overnight before the experiment, and fasted during the experiment.

Rats were treated with alcohol alone (control),
The test was divided into xylitol-administered groups and performed in groups of 5 animals. A control group to which alcohol alone was administered was orally administered with a 38 v / v% ethyl alcohol aqueous solution, and a xylitol administration group was orally administered with a 38 v / v% ethyl alcohol aqueous solution containing 5 w / v% xylitol in a volume of 10 ml / kg. After the administration, observations were made until the symptoms of sickness recovered.

As a result, it took 5 hours for the alcohol alone administration group to recover from the sickness symptoms, and when administered, the symptoms were prone, staggered walking and reduced grip strength, whereas the xylitol administration group showed It was observed that the sickness symptoms recovered within one hour, and that the symptoms when administered were mildly staggered. From these results, it was confirmed that xylitol has a remarkable effect of preventing sickness symptoms during drinking.

Example 2 In accordance with Example 1, the same experiment was conducted using sorbitol, trehalose, erythritol, and multinit as sickness preventive agents. In addition,
The alcohol concentration is 38 v / v% ethyl alcohol, and the sickness prevention agent concentration is 5 w / v%.

As a result, sorbitol, trehalose,
The group to which erythritol and multi-nit samples were administered
In each case, the recovery from the sickness symptom was about 2 to 3 hours, and the recovery was faster than in the alcohol alone administration group. From this,
It was confirmed that sorbitol, trehalose, erythritol, and multinit had an effect of preventing sickness symptoms during drinking, similarly to xylitol.

[Example 3] Twenty adult men who had a drinking habit and had experienced sickness such as hot flush, headache, nausea, etc. were weighed 1 kg per person 30 minutes before drinking.
After taking 80 mg of xylitol granules per person, each person had to drink alcohol according to the amount and type (beer, sake, wine, western liquor, etc.) when they experienced sickness in the past, and the occurrence of sickness symptoms Was examined.

As a result, in all the subjects, the symptoms of the drunkenness while drinking are not drunken, but rather tipsy.
No discomfort such as headache and nausea appeared, and the symptom of sickness was quickly resolved. From this, it became clear that xylitol has a remarkable effect of preventing sickness symptoms during drinking.

Example 4 Another 30 male adults were selected from Example 3 who had a drinking habit and experienced sickness such as hot flush, headache, nausea, etc., and divided them into 2 groups of 15 persons. In the same manner as in Example 3, drinking was performed in accordance with the amount and type (beer, sake, wine, western liquor, etc.) of alcohol that had experienced sickness in the past. One group took 80 mg / kg of each person's body weight per person after 10 minutes and the other group did not. The subsequent situation of occurrence of discomfort was examined.

As a result, in the group who did not take 1
All five had a headache, and six of them had nausea. However, only three people in the group who took the drug had a mild headache, and the remaining twelve had no sickness symptoms such as headache and nausea, and they felt that the sickness symptoms were reduced. This indicates that xylitol has an effect of preventing sickness symptoms even when taken immediately after drinking.

[0023]

According to the agent for preventing sickness of the present invention, sickness due to alcohol can be effectively prevented before or during drinking.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification code FI Theme coat ゛ (Reference) // C07H 3/04 C07H 3/04 (72) Inventor Kaori Arita 1-3-3 Honjo, Sumida-ku, Tokyo 7 Inside Lion Corporation (72) Inventor Keiko Kazuno 1-37 Honjo, Sumida-ku, Tokyo F-Term Inside Lion Corporation 4C057 BB03 4C086 AA01 AA02 EA01 MA01 MA02 MA03 MA04 4C206 AA01 AA02 CA05 MA01 MA02 MA03 MA04 ZC37 ZC39

Claims (2)

[Claims] 1. A sickness-preventing agent comprising a sugar alcohol as an active ingredient. 2. The sugar alcohol is xylitol, erythritol, sorbitol, mannitol, threitol,
The agent for preventing sickness according to claim 1, which is one or more selected from arabitol, ribitol, galactitol, rhamnitol, trehalose, and multinit.