JP2001089929A - Gelatin fiber, its production, gelatin fiber aggregate and bioabsorbable material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a gelatin fiber, establish a process for the production of the gelatin fiber and obtain a gelatin fiber aggregate and a bioabsorbable material composed of a gelatin fiber aggregate from the gelatin fiber. SOLUTION: It has been found that the use of a specific mixed solution as a solvent for dissolving gelatin gives a fibrous material from the solution and the produced fibrous material has been confirmed as a gelatin fiber unattainable by conventional technique. Further, a stable and transparent gelatin solution having a viscosity suitable for the spinning of gelatin at room temperature can be produced by the use of a specific mixed solution as the solvent for gelatin. The gelatin solvent is a solution containing an amide compound and an alkali metal or alkaline earth metal halide. The gelatin fiber is produced by coagulating a solution containing the solvent and gelatin with a coagulation liquid.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a gelatin fiber having mechanical properties and water resistance which can be used mainly as a bioabsorbable material or a food packaging material, and a method for producing the same. Further, the present invention relates to an aggregate of gelatin fibers produced from such gelatin fibers.

[0002]

2. Description of the Related Art Gelatin is produced by unraveling a triple helical molecule of collagen obtained from bovine bone, cow skin, pig skin and the like, and has been known to be soluble in water. However, an aqueous solution of gelatin obtained by dissolving gelatin in water has low yarn-drawing properties at low concentrations and gels at high concentrations, making it impossible to produce fibers. Therefore, conventionally, gelatin has only been used as a sponge, a film or the like, and a method for producing gelatin fibers is not known. For example, it is used as a sponge-like local hemostatic material (trade name: Sponzel, manufactured by Yamanouchi Pharmaceutical Co., Ltd.) in the medical field, but loses its form immediately upon contact with water and has poor water resistance. Nevertheless, nonetheless, gelatin has long been favorably used as a sponge-like hemostatic material because it has low antigenicity when placed in a living body and has a conventional bioabsorbable material (eg, polyglycolic acid, This is because the bioabsorbability is much faster than that of polylactic acid, collagen, etc.), so that it has high safety and is extremely excellent as a bioabsorbable material.

[Problems to be solved by the invention]

[0003] In recent years, such bioabsorbable materials have a large role to play, and have been used for the purpose of tissue repair or tissue replacement in vivo with the advancement of medical technology, but the bioabsorption is delayed. In such a case, there is a concern that safety problems may remain because the residual foreign substances may cause side effects.

[0004] On the other hand, gelatin is very preferable in terms of safety because it has a quick bioabsorbability.
Therefore, a molded product of gelatin having high strength and high water resistance,
In particular, if the production of fibers becomes possible and the production of such fiber aggregates becomes possible, there is no doubt that the field of application of gelatin as a bioabsorbable material will greatly expand. Examples of bioabsorbable materials include artificial dura, anti-adhesion materials, materials for treating pressure sores, and local hemostatic materials.When worn on living bodies, these materials require structurally high physical properties. After use, it is required to be immediately absorbed by the living body. However, gelatin is known to be extremely weak (low in water resistance) to water, and there is a limit to its use as such a material.

Therefore, the first object of the present invention is to obtain a novel gelatin fiber which has not been produced so far, and a second object is to establish a method for producing such a gelatin fiber. In addition, a third object is to obtain a gelatin fiber aggregate and a bioabsorbable material comprising the gelatin fiber aggregate from such gelatin fibers.

[0006]

Means for Solving the Problems The present inventors have proposed the first method.
In order to solve the second problem, a method for producing gelatin fibers by wet spinning has been devoted to the search for a suitable solvent for preparing a solution containing gelatin. As a result, it was found that if a specific mixed solution was used as a solvent for dissolving gelatin (hereinafter, referred to as a gelatin solvent), a fibrous material could be produced from the gelatin solution, and this fibrous material could not be obtained conventionally. It was confirmed to be gelatin fiber. That is, a means for solving the first problem according to the present invention is a gelatin fiber in which gelatin is formed in a fibrous form.

Furthermore, it has been found that when the above-mentioned gelatin solvent is a specific mixed solution, a stable and transparent gelatin solution having an appropriate viscosity for spinning at room temperature can be obtained. That is, a means for solving the second problem according to the present invention is a solution containing an amide compound, a halogen salt of an alkali metal or an alkaline earth metal, and gelatin.
A method for producing a gelatin fiber obtained by coagulation with a coagulation liquid.

Further, in the above-mentioned method for producing gelatin fibers, a method of adding an aldehyde to a gelatin solution;
Further, a method is preferred in which a gelatin solution is coagulated with a coagulating liquid, and then a polyhydric alcohol or a derivative thereof is added and stretched.

Further, the present inventors have proposed that the above-mentioned gelatin fibers can be processed as various aggregates, and the manufactured gelatin fiber aggregates have a stable physical structure, so that the aggregates can be used for damaged parts of the body. The present inventors have found that the bioabsorbable material can be easily and easily worn, and that the bioabsorbable material can be quickly absorbed after use, thereby achieving the object of the bioabsorbable material. That is, the means for solving the third problem according to the present invention lies in a gelatin fiber aggregate obtained by processing the gelatin fiber and a bioabsorbable material comprising the gelatin fiber aggregate.

[0010]

Embodiments of the present invention will be described below. Gelatin, as mentioned above,
It is produced as a single molecule by unraveling the triple helix of collagen obtained from bovine bone, cow skin, pig skin and the like. The method for producing gelatin includes an acid treatment method for a gelatin raw material and a lime treatment method.
Commercially available gelatin can also be used in the present invention. In addition, since commercially available gelatin undergoes various purification steps before being extracted in the production process,
There are few components other than protein.
In general, the composition is 5% or more, water is 8 to 14%, ash content is 2% or less, and other (lipid, polysaccharide, etc.) is 1% or less. In the present invention, such general gelatin can be used. In addition, gelatin having a wide molecular weight can be used.

The gelatin solvent of the present invention comprises an amide compound,
A solution or an aqueous solution containing a halogen salt of an alkali metal or an alkaline earth metal. The amide compound refers to a polar organic liquid having an amide in a molecule, for example, dimethylacetamide, N-methylpyrrolidone, dimethylsulfamide, and the like.A halogen salt of an alkali metal or an alkaline earth metal includes, for example, chloride Examples thereof include lithium, sodium chloride, and calcium chloride. With respect to the mixing ratio of the amide compound and the halogen salt of an alkali metal or alkaline earth metal (hereinafter referred to as "halogen salt"), if the amount of the halogen salt relative to the amide compound is large, the viscosity of the solution is reduced and sufficient filamentability It is difficult to prepare a solution having the following, and if the amount of the halogen salt is small relative to the amide compound, gelation occurs and the ductility is lowered, so that the ductility cannot be obtained. Therefore, based on 100 parts by weight of the amide compound,
The halogen salt is preferably mixed in an amount of 5 to 15 parts by weight.
The amount of water added to the mixture of the amide compound and the halogen salt is preferably in the range of 20 to 80 parts by weight based on 100 parts by weight of the mixture from the viewpoint of suppressing the dissociation of the halogen salt. Further, the concentration of gelatin dissolved in the gelatin solvent can be prepared in a wide range.However, if the gelatin concentration is too low, the ductility of the gelatin solution is too low, spinning becomes impossible, and if the gelatin concentration is too high, However, it becomes gel like a normal gelatin aqueous solution. Therefore, what is used in the present invention is gelatin solvent 10
It is preferable that gelatin is 5 to 30 parts by weight with respect to 0 parts by weight.
Gelatin is preferably 10 to 20 parts by weight with respect to 00 parts by weight.

The method of dissolving gelatin in the gelatin solvent is not particularly limited. For example, an amide compound and a halogen salt, water and gelatin may be mixed at the same time. Considering the properties that are easy to perform, water and gelatin are heated to a high temperature (for example, 60 ° C.).
Above), and after completely dissolving, a method of adding the previously mixed mixture of the amide compound and the halogen salt is preferable. As a result, it is possible to obtain a yellow-clear, relatively low-viscosity solution at room temperature.

In the case where fibers are actually produced from the gelatin solution, if the viscosity is high and the yarn has ductility, the production of the fibers is easy, so that a crosslinking agent should be added to the gelatin solution. Is preferred. As the crosslinking agent, aldehydes (for example, formaldehyde, acetaldehyde,
Glutaraldehyde) are common and these are added as aqueous solutions. The addition of such a cross-linking agent increases the viscosity of the gelatin solution, so it is preferable to add the cross-linking agent while adjusting the viscosity so that spinning is easy. The amount of the cross-linking agent added is important, which also affects the properties (particularly water resistance) of the obtained gelatin fiber, and is preferably 0.01 to 0.1 part by weight based on 100 parts by weight of the gelatin solution.

In order to obtain fibers from the gelatin solution, a usual wet spinning method can be employed. Hereinafter, this wet spinning method will be described. First, the gelatin solution obtained as described above is subjected to pressure filtration using a stainless steel filter of about 600 to 2000 mesh. The gelatin solution after filtration is defoamed under reduced pressure or standing,
It is transported by a gear pump from a tank pressurized at 5 to 10 kg / cm ² , and 0.05 to 0.5 m
A plurality of nozzles having a diameter of about mφ are extruded into a coagulation bath containing a coagulation liquid. The coagulation liquid is preferably an organic solvent such as alcohols, ketones and ethers. Examples of alcohols include methanol, ethanol, butanol, and the like.Examples of ketones include acetone, 2-ketopropyl alcohol, cyclohexanone, and the like.Examples of ethers include diethyl ether, tetrahydrofuran, dioxane, and the like. Is exemplified. Further, the temperature of the coagulation liquid varies depending on the viscosity of the gelatin solution, but it is generally preferable to heat the coagulation liquid to about 30 to 50 ° C. The gelatin fiber extruded and coagulated into the coagulation liquid is wound as it is on a bobbin or the like at a speed of about 1 to 10 m / min, and after sufficiently removing the coagulation liquid, it is stretched, or it is stretched with a roller immediately after being taken out. Stretch. At this time, if the solvent remains adhered to the gelatin fibers, the gelatin fibers are likely to adhere to each other after stretching. Therefore, it is preferable to perform stretching after sufficiently removing the coagulating liquid. The stretching magnification is about 2 to 8 times, and it is preferable to stretch as much as possible. In addition, at the time of stretching, the coagulation liquid has high volatility, and ketones and ethers may be rapidly eliminated and may deteriorate the physical properties of the fiber. Glycerin, polyethylene glycol, etc.).
As an addition method, for example, a method of immersing gelatin fibers in a polyhydric alcohol solution is exemplified. When the obtained yarn is sufficiently washed with a coagulating liquid and then dried under tension, colorless and high-quality gelatin fibers having a single yarn diameter of 5 to 100 μm can be obtained. The strength of such a gelatin fiber is about 1 to 3 g / d,
It does not dissolve immediately in water. In order to further improve the water resistance, gelatin fibers may be immersed in an aldehyde or the like and crosslinked again.

The above-mentioned gelatin fibers can be processed in the form of long fibers or short fibers. Therefore, various kinds of gelatin fiber aggregates (for example, cotton-like laminates) can be produced from such gelatin fibers by a general processing method. , A nonwoven fabric, a knitted fabric, a woven fabric, or a fibrous cloth made of the same). For example, when preparing a cotton-like laminate, a gelatin fiber cut to a length of about 10 mm is set on a card machine equipped with a metal needle, opened to be flocculent, and fixed with a needle punch machine. A laminate can be produced. In the case of a nonwoven fabric, short fibers of about 1 to 10 mm are formed, dispersed in alcohol or the like, and then the alcohol is removed and the laminate is compression-fixed to produce a nonwoven fabric. The knitted fabric can be produced by a knitting machine used when processing clothing fibers. Furthermore, for woven fabrics, with a normal weaving machine using warp and weft,
Can be made. Further, the density of the gelatin fiber aggregate can be produced by adjusting the amount of the fiber used depending on the purpose of use. The above-mentioned gelatin fiber aggregate is cut into a required size, and then subjected to a manufacturing process, that is, cutting, sterilization, packaging, etc., to perform various bioabsorbable materials (for example, artificial dura or adhesion prevention). Materials, wound protection materials, etc.) and can be used. In particular, the bioabsorbable material produced from the gelatin fiber aggregate of the present invention has excellent physical properties such as water resistance and strength. It can be securely attached without being destroyed. After being worn, it is bioabsorbed early and disappears from the site within at least two weeks. Hereinafter, an example of use as a bioabsorbable material will be described.

The artificial dura is used in place of the dura to protect the brain after a brain operation. Conventionally, a cadaver dura was used, but the treatment was insufficient. In case,
There have been cases of Kreutzell-Jakob disease, and their use is anxious. The artificial dura with the gelatin fiber aggregate of the present invention is used in place of the dura. Taking into account the properties required for the dura, it is preferable to use a high-density structure such as a knitted or woven fabric and a firm structure. When the artificial dura with the gelatin fiber aggregate of the present invention is used, the shape is very stable two to three days after the protection, and two weeks later, the gelatin fiber is formed together with the growth of the pseudo-dura. Since the artificial dura disappears, it can be said that the artificial dura is a preferable material for the artificial dura.

The adhesion preventing material is used for preventing adhesion after surgical operation. Adhesions occur as a result of wounds adhering to each other after surgery, particularly in utero and pelvis surgery in obstetrics and gynecology, tendon or ligament surgery in orthopedic surgery, and digestive organs such as large and small intestine in abdominal surgery. After surgery, adhesions are likely to occur and cause complications. If adhesions occur, reoperation is necessary. Such adhesions occur in 67-93% of all abdominal operations according to British statistics,
Above all, 28.5% of small bowel operations have complications caused by adhesions. Therefore, the cost of reoperation is increasing, and according to US statistics, the cost is 1998
According to a yearly survey, it has reached 1,179 million dollars (approximately 125 billion yen), and there is a large reduction in medical expenses if improved by appropriate measures. Generally, adhesions
It is said to occur when the fibrin deposits after the wound and the fibrin does not dissolve sufficiently. As a measure to prevent adhesions, there is an improvement in surgical techniques, but now that the techniques have improved, there are also limitations, and now methods of isolating wounds with drugs or medical materials are mainly studied. . In the past, many medical materials have been considered as anti-adhesion materials, but currently only two materials in Japan are used in medical institutions, the oxidized cellulose film and the hyaluronic acid film, and insurance is applied to the pelvis. Since it is limited to a part of the operation, the amount used is small. This is because the performance is not sufficiently satisfied, and it is said that the bioabsorbability is particularly slow. The anti-adhesion material comprising the gelatin fiber aggregate according to the present invention is a material that has a high bioabsorbability and can sufficiently compensate for these disadvantages.

Further, the gelatin fiber aggregate according to the present invention can be used as a material for treating pressure sores. Pressure sores, commonly referred to as bedsores, occur when a bedridden patient presses on the same area for a long time, especially near the iliac bone.
In some cases, it is accompanied by a widespread skin defect, and when the pressure sore is severe, a defect called a pocket, which does not appear on the surface of the skin, occurs. Many wound protectors are still used today to treat such pressure sores, but if the wound protector protects this defect, it will not bioabsorb or, if it is slow, will not heal rather than heal. May occur and hinder wound healing. The gelatin fiber aggregate according to the present invention has an advantage that the wound surface can be suitably protected without generating bad granulation because it has good bioabsorbability and is quickly absorbed by the living body.

[0019]

Example 1 An example of a method for producing a gelatin fiber according to the present invention will be described below. First, 170 g of gelatin granules (manufactured by Nitta Gelatin, manufactured by an acid treatment method, and the viscosity of a 4% aqueous solution is 25 mp at 60 ° C.) are mixed with 283 g of distilled water, heated to 80 ° C., and sufficiently dissolved. Dimethylacetamide solution 70 in which 70 g of lithium chloride is dissolved
When 0 g was added and stirring was continued at 80 ° C., a yellow transparent gelatin solution was obtained. When this was returned to 25 ° C., it became a yellow transparent fluid liquid. When a 10 cc aqueous solution containing 0.275 g of glutaraldehyde was added to the gelatin solution with stirring, the viscosity of the gelatin solution was increased to give a syrupy high-viscosity liquid. This gelatin solution was filtered through a 1480 mesh stainless steel filter at a pressure of ² kg / cm ² . Thereafter, the container containing the gelatin solution was connected to a water-flow type decompression hose, and defoamed all day long to completely remove the foam. This gelatin solution is put in a tank, and while being introduced with 8 kg / cm ² of nitrogen and pressurized, transported by a gear pump of 0.05 to 0.5 cc / sec, filtered through a 1480 mesh stainless steel filter through a pipeline. After that, 0.2
The fiber was extruded and solidified from a platinum nozzle with a diameter of 100 mm and into a coagulating liquid, thereby spinning. The coagulation liquid used methanol, and the temperature was 40 ° C. The spun yarn was taken out at a speed of 3 m / min and washed again in methanol for 24 hours. After washing, it was immersed in a 10% by weight solution of polyethylene glycol having a molecular weight of 400, and then stretched 5.2 times with a rotating roller to obtain a gelatin fiber. Gelatin fibers are colorless and of good quality. When measured for physical properties, the diameter of a single yarn of the fiber is 20 μm, the dry strength of the single yarn is 2.5 g / d, the elongation is 58%, and The wet strength was 0.8 g / d and the elongation was 180%.
In addition, the gelatin fiber retained a sufficient shape even when immersed in water, indicating that it had sufficient physical properties as a medical material. In addition, about the measuring method of intensity | strength and elongation, it performed according to JIS measuring method.

[0020]

Example 2 Next, the gelatin fiber obtained in Example 1 was immersed in a methanol solution containing 1% by weight of glutaraldehyde for about 1 hour, and then woven with a weaving machine (gelatin fiber) in the form of a long fiber as it was. Fabric). Processing was easy, and a high density gelatin fiber cloth could be produced. The thickness of the obtained gelatin fiber cloth is 1.5
mm. Such a gelatin fiber cloth was used as an artificial dura. Rabbits were used as animals. That is, the skull of the occiput was excised under anesthesia, and after exposing the brain, a slight abrasion was made on the surface of the brain with sandpaper, and a gelatin fiber cloth was attached to the surface. The gelatin fiber cloth easily adhered to the abraded surface and securely covered the brain surface. After that, the scalp was covered, and one week later, the head was opened and the surface of the brain with gelatin fibers was observed.The surface was covered with a thin gel and new tissue was formed, but the gelatin fiber cloth was sufficiently identified. could not. Therefore, it could be observed that the gelatin fiber cloth reliably protected the injured brain and that the bioabsorption was performed early.

[0021]

Example 3 A gelatin nonwoven fabric was produced using the gelatin fiber of Example 1. Gelatin fiber length 5
mm, and sufficiently dispersed in a methanol solution. Thereafter, methanol was removed to prepare a gelatin fiber laminate. The laminate was compressed at a pressure of about 10 kg / cm ² to produce a gelatin nonwoven fabric having a thickness of about 0.2 mm. This gelatin nonwoven fabric was sterilized with ethylene oxide gas and used as an adhesion preventing material. The animals used were rats. The abdomen of the rat was opened, the cecum was taken out, and rubbed with sandpaper for about 10 seconds to prepare an abrasion wound. Also, 3cm
The peritoneum was peeled and excised in a range of × 3 cm. A 4 cm × 4 cm gelatin nonwoven fabric was attached between the cecum and the peritoneum. Further, in another rat, the same treatment was performed at the site where no treatment was performed, and a rat having an oxidized cellulose membrane (manufactured by Johnson & Johnson, trade name; Interseed) was prepared. A comparison was made with a rat provided with a gelatin nonwoven fabric. The gelatin nonwoven fabric adhered firmly to the affected area and was easy to attach, whereas the oxidized cellulose film was inferior to the gelatin nonwoven fabric in adhesion to the affected area. Regarding the effect of the adhesion, a method was adopted in which the abdomen was opened one week later, the state of the adhesion was visually observed, and the degree of the adhesion was evaluated in three stages. The three stages were those in which no adhesion was observed (A), those in which adhesion occurred in part (B), and those in which adhesion was observed in half or more (C). Ten rats were used for each of the three experiments. As a result, the number of rats was as follows: A: 0, B:
2, C: 8, those using an oxidized cellulose membrane, A:
1, B: 3, C: 6, but when gelatin non-woven fabric was used, A: 3, B: 5, C: 2, and the use of gelatin non-woven fabric caused the least adhesion. Was. In addition, regarding the remaining of the material in the living body, in the observation after one week, when the oxidized cellulose membrane was used, the remaining was confirmed. Was not observed.

[0022]

Example 4 The gelatin fiber obtained in Example 1 was cut to a length of 10 mm, and opened by a carding machine having a large number of needles to produce a cotton-like laminate. This cotton-like laminate was fixed with a needle punch to prepare a 2 mm-thick mat-like gelatin fiber cloth. The gelatin fiber cloth was sterilized, buried on the fascia of a wound applied to a rabbit, and the condition was observed. That is, the back skin of the rabbit was first incised and peeled to expose the fascia, and a 3 cm × 5 cm rectangular part of the fascia was peeled. When a gelatin fiber cloth was mounted on the exfoliated wound, it adhered firmly. For comparison, a calcium alginate fiber cloth (manufactured by Bristol-Myer Squibb, trade name: Sorbusan), which is generally used as a material for treating pressure sores, was used. After wearing, the skin was sutured again, and after 5 days, the incision was made and the affected part was observed. When a gelatin fiber cloth was used, progress of healing was observed in the affected part, and the gelatin fiber cloth could not be confirmed. . On the other hand, when the calcium alginate fiber cloth was used, most of the material remained on the wound surface, and the progress of healing was slow. From the above experiments, when the gelatin fiber cloth is attached to the wound inside the body,
Implantation means that the wound can be reliably protected and absorbed early, and can be buried in a pressure sore, especially a pocket-like wound that spreads inside the skin, to aid wound healing. It became clear that it was suitable as a therapeutic material for pressure sores.

[0023]

According to the present invention, it is possible to produce gelatin fibers having high tension, water resistance and easy handling, and it is possible to obtain gelatin fibers having higher bioabsorbability than conventional therapeutic materials. Also, by adding aldehydes to the gelatin solution, the production of gelatin fibers becomes much easier. Furthermore, in the production of gelatin fibers, after the gelatin solution is coagulated in a coagulating solution, a polyhydric alcohol is added, so that the gelatin fibers can be easily drawn. Gelatin fiber aggregates made from such gelatin fibers can be used for bioabsorbable materials requiring rapid bioabsorption (eg, artificial dura, anti-adhesion material, material for treating pressure sores,
Material for preventing hemostasis).

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[Procedure amendment]

[Submission date] March 13, 2000 (200.3.1)
3)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claims

[Correction method] Change

[Correction contents]

[Claims]

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0005

[Correction method] Change

[Correction contents]

[0005] The present invention has thus far as a first object is to establish a method of manufacturing a novel gelatin fibers not come to be produced, in addition Kakaru gelatin fiber aggregate of gelatin fibers and gelatin fibers A second object is to obtain a bioabsorbable material composed of an aggregate.

[Procedure amendment 3]

[Document name to be amended] Statement

[Correction target item name] 0006

[Correction method] Change

[Correction contents]

[0006]

Means for Solving the Problems The present inventors have proposed the first method.
In order to solve the second problem, a method for producing gelatin fibers by wet spinning has been devoted to the search for a suitable solvent for preparing a solution containing gelatin. As a result, it was found that if a specific mixed solution was used as a solvent for dissolving gelatin (hereinafter, referred to as a gelatin solvent), a fibrous material could be produced from the gelatin solution, and this fibrous material could not be obtained conventionally. It was confirmed to be gelatin fiber .

[Procedure amendment 4]

[Document name to be amended] Statement

[Correction target item name] 0007

[Correction method] Change

[Correction contents]

[0007] That is, the second aspect of the present invention1Solve the problem
Means for determining the amide compound, alkali metal or
Solutions containing alkaline earth metal halides and gelatin
Gelatin fiber obtained by coagulating liquid with coagulating liquidAnd that
ofIn the manufacturing method.

[Procedure amendment 5]

[Document name to be amended] Statement

[Correction target item name] 0009

[Correction method] Change

[Correction contents]

Further, the present inventors have proposed that the above-mentioned gelatin fibers can be processed as various aggregates, and the manufactured gelatin fiber aggregates have a stable physical structure, so that the aggregates can be used for damaged parts of the body. The present inventors have found that the bioabsorbable material can be easily and easily worn, and that the bioabsorbable material can be quickly absorbed after use, thereby achieving the object of the bioabsorbable material. That is, the means for solving the second problem according to the present invention lies in a gelatin fiber aggregate obtained by processing the gelatin fiber and a bioabsorbable material comprising the gelatin fiber aggregate.

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Claims (7)

[Claims] 1. A gelatin fiber, wherein the gelatin is formed in a fibrous form. 2. A solution containing an amide compound, an alkali metal or alkaline earth metal halide, and gelatin.
A gelatin fiber obtained by coagulation with a coagulation liquid. 3. A solution containing an amide compound, an alkali metal or alkaline earth metal halide, and gelatin.
A method for producing a gelatin fiber, comprising obtaining a fibrous material by coagulating with a coagulating liquid. 4. The method for producing a gelatin fiber according to claim 3, wherein an aldehyde is added to the gelatin solution, followed by coagulation. 5. The method for producing a gelatin fiber according to claim 3, wherein the gelatin solution is coagulated with a coagulating liquid, and then a polyhydric alcohol or a derivative thereof is added and drawn. 6. A gelatin fiber aggregate obtained by processing the gelatin fiber according to claim 1 or 2. 7. A bioabsorbable material comprising the gelatin fiber aggregate according to claim 6.