JP2001057991A - Air permeable pasting agent and its production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a pasting agent that has 'existence of uniform cells on the whole face of the pasting agent', 'sufficient adhesion as a pasting agent', 'plaster quantity that can secure necessary amount of medically effective components' and 'uniformity of applied plaster quantity' together, and to relieve hindrance of skin respiration and such cutaneous lesions as rash caused by stuffiness in conventional pasting agents. SOLUTION: This pasting agent with good air permeability is prepared by applying plaster 1 on a single face of an air permeable support 2 made from woven or nonwoven fabric using a rotary screen printing system so as to have clearances 3 in a pattern formed in netting or meshes with a size of 10 to 60 meshes. This serves relief of hindrance of cutaneous respiration or stuffiness and an air permeable pasting agent without lowering adhesion is obtained even when applied to such portions easily getting stuffy as the sole.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch having excellent air permeability and a method for producing the same. More particularly, the present invention relates to a skin patch such as a rash due to coating on the skin surface when applied, and The present invention relates to a patch which does not cause a decrease in adhesive strength due to unevenness caused by sweating or the like, and an efficient production method thereof.

[0002]

2. Description of the Related Art Although a large number of patches have been provided which exert a medicinal effect when applied to the skin, as described above, there is a general drawback that skin patches such as rash may be caused. One of the causes of skin disorders is obstruction of skin respiration and unevenness.However, evaporative moisture or sweat from the skin that collects between the patch and the skin causes skin irregularity, and the inflammatory substances in the stratum corneum It has been reported to dissolve in the water and cause inflammation.

Another drawback of the conventional patch having low air permeability is that, when the patch is applied to a part which is particularly easily peeled, for example, the sole of a foot, the adhesive strength decreases with time and the adhesive easily falls off. . However, increasing the adhesive strength of the plaster alone did not solve the peeling or turning over, and it was considered necessary to control the unevenness. Moreover, in such a site, the stratum corneum is thick and a transdermal absorption enhancer is often required in order to absorb the drug transdermally, but this transdermal absorption enhancer further reduces the adhesive force. Was a factor.

[0004] As a technique for alleviating the obstruction or irregularity of skin respiration caused by a patch, there is a technique of mechanically punching a hole from a support to a plaster to obtain air permeability.
However, since the strength of the patch after perforation is reduced or the support and the plaster at the portion of the perforated hole are wasted, the ratio of the area occupied by the hole to the entire patch is at most 1 to 5 %, And thus this method did not provide sufficient air permeability.

In some cases, a patch having a conventional plaster layer provided on one side of a gas-permeable support has excellent air permeability, but in practice, the plaster layer itself has almost air permeability. As a result, obstruction and unevenness of skin respiration are not alleviated.

[0006] Alternatively, JP-A-63-203615 and JP-A-1-297695 disclose a technique in which a highly water-absorbing polymer is blended into a plaster to absorb moisture due to skin respiration and perspiration. However, although a certain amount of water absorption can be expected, there is a disadvantage that the superabsorbent polymer that has absorbed water and swelled reduces the adhesive strength of the patch to the skin.

[0007] A patch in which a porous layer is applied to a breathable support is excellent in breathability, and can be expected to have an excellent effect in preventing skin respiration and alleviating unevenness. Conventionally, various patches and methods for producing the same have been reported. For example,
Japanese Patent No. 10854 describes a method in which a crack is generated by shrinkage of the paste in the step of drying the paste, but has problems such as poor drying efficiency and uniform pores cannot be obtained.

Japanese Patent Publication No. Sho 62-14197 discloses a method in which a foaming agent is added to a plaster to provide air permeability at a foaming portion of the plaster. There was a risk of weakness.

Japanese Patent Publication No. 51-33811 describes a method in which air bubbles or liquid bubbles are dispersed in a plaster, and the air bubbles are formed by the air bubbles or the liquid bubbles. There was a problem with stability.

Japanese Patent Application Laid-Open No. 56-2909 discloses a technique in which plasters are applied in a number of rows or in a mesh by a printing method such as a gravure roll method, an offset printing method, and a silk screen printing method. However, in printing coating by a roll method such as a gravure roll method, the paste to be printed is crushed due to pressurization by the roll, and the air-permeable support surface between the pastes is closed by the paste. There was a problem that good air permeability could not be obtained. In addition, the silk screen printing method has a problem in that continuous production cannot be performed and the cost increases.

Japanese Patent Application Laid-Open No. 11-33103 discloses a polyethylene laminated surface of a laminated base material in which low-density polyethylene having a density of 0.93 g / cm ³ or less is laminated on one surface of a gas permeable base material at a thickness of 3 to 10 μm. The coating amount after drying the organic solvent solution of the pressure-sensitive adhesive having a solid content of 10 to 70% by weight is 5 to 100 g /
m ² and heated to 130-200 ° C.
A method for producing a breathable pressure-sensitive adhesive tape characterized by drying and forming a myriad of fine holes in the low-density polyethylene layer is described, but since the pressure-sensitive adhesive layer has no holes, skin such as rash Insufficient air permeability to mitigate the obstacle is not obtained. The publication further contains 10 to 100% by weight of rayon fiber and / or cellulose fiber, and the permeable base material contains 0.5 to 50 parts by weight of water per 100 parts by weight of the permeable base material. After that, an organic solvent solution of the adhesive having a solid content of 10 to 70% by weight was applied using a reverse coater so that the applied amount after drying was 5 to 100 g / m ^2, and heated to 130 to 200 ° C. A method for producing a breathable pressure-sensitive adhesive tape, characterized by drying and forming an infinite number of fine holes in the pressure-sensitive adhesive layer,
It was difficult to obtain uniform pores over the entire surface because the fine pores formed depend on the surface condition of the air-permeable substrate, the drying temperature, and the viscosity of the adhesive. Further, when an infinite number of holes are formed, the ratio of the area occupied by the holes is not always constant, so that there is a disadvantage that physical properties such as adhesive strength vary.

As described above, the conventional air-permeable patch and the method for producing the same do not provide uniform pores over the entire surface of the patch, make it difficult to control the production conditions, and reduce the adhesiveness required for the patch. Chipping, pores disappear in a short time, sufficient air permeability cannot be obtained, required amount of plaster (amount of medicinal ingredient)
However, there are still many problems such as inability to apply, continuous production, and complicated processes.

[0013]

SUMMARY OF THE INVENTION In order to solve the above-mentioned drawbacks of the prior art, the present invention is directed to "existence of uniform pores over the entire surface of the patch", "sufficient adhesiveness as a patch", We provide patches that combine the amount of plaster that can secure the amount of medicinal ingredients and the uniformity of the amount of plaster applied to prevent skin disorders such as obstruction of skin respiration and rash due to irregularities, which were present in conventional patches. Relaxation is an object and object of the present invention.

[0014]

Means for Solving the Problems Accordingly, the present inventors have:
As a result of earnest research on the adhesive technology and the porous technology, on one side of a breathable support such as a woven fabric or a nonwoven fabric, the paste is formed by rotary screen printing so that the mesh size becomes 10 to 60 mesh. In addition, a patch having excellent breathability was obtained by applying a gap having a mesh shape or a pattern composed of meshes, and a breathable patch was obtained in which interference with skin respiration and relief were reduced. .

As a result, the breathable patch of the present invention is
It has also been found that it is possible to stick for a long period of time in places where sweating is likely or where it is likely to be disturbed. This is considered to be a very advantageous property, especially when considering the application of the patch to the sole of the foot (eg treatment of tinea pedis, etc.).

The support used in the present invention is not particularly limited as long as it has air permeability, and a woven fabric, a nonwoven fabric and the like can be used. For example, a woven fabric of fibers such as cotton, woolen, nylon, rayon, polyester, and polypropylene is used as the woven fabric, and the weaving method, density, fiber denier, and the like are not particularly limited. As the nonwoven fabric, a single fiber of rayon, cellulose, nylon, polypropylene, polyester or the like or a mixture thereof is used, and the weaving method, density, fiber denier and the like are not particularly limited.

The pressure-sensitive adhesive serving as the base of the plaster used in the breathable patch of the present invention is appropriately selected from oil-based pressure-sensitive adhesives. Examples of the component of the adhesive include styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, polyacrylate copolymer, natural rubber, various synthetic rubbers, and the like. Tackifier such as terpene resin, aliphatic synthetic resin, rosin resin, rosin ester resin, softener such as liquid paraffin, naphthene oil, polybutene, polyisobutylene, and titanium oxide as needed ,
Examples thereof include fillers such as zinc oxide and those obtained by blending an antioxidant.

The following are typical examples of medicinal ingredients that can be used in the breathable patch of the present invention. Corticosteroids: for example, hydrocortisone, prednisolone, beclomethasone propionate, flumethasone, etc. Analgesic and anti-inflammatory agents: for example, acetaminophenone, mefenamic acid, flufenac acid, diclofenac sodium,
Salicylic acid, monoglycol salicylate, 1-menthol, camphor, etc. Hypnotic sedatives: for example, phenobarbital, amobarbital, triazolam, etc. Mental stabilizers: for example, fluphenazine, theorytazine, diazepam, chlorpromazine, etc. Antihypertensive agents: for example, clonidine, pindolol , Propranolol, bupranolol, etc. Antihypertensive diuretics: for example, hydrothiazide, bendroflunathiazide, etc. Antibiotics: for example, penicillin, tetracycline, oxytetracycline, fradiomycin hydrochloride, etc. Anesthetics: for example, lidocaine, dibucaine hydrochloride, benzocaine, aminobenzoic acid Antibacterial substances such as ethyl: for example benzalkonium chloride, nitrofurazone, acetosulfamine, clotrimazole, tolnaphte Vitamins: for example, vitamin A, ergocalciferol, riboflavin butyrate, etc. Antiepileptic agents: for example, nitrazepam, meprobamate,
Clonazepam, etc. Coronary vasodilators: nitroglycerin, isosorbide dinitrate, pentaerythritol tetranitrate, etc. Antihistamines: diphenhydramine hydrochloride, chlorpheniramine, diphenylimidazole, etc. Antitussives: salbutamol sulfate, isoproterenol sulfate, tulobuterol hydrochloride , Ephedrine, etc. Sex hormones: for example, progesterone, estradiol, etc. Antiemetic agents: for example, scopolamine, crevopride, 5-fluorouracil, mercaptopurine, etc. These drugs can be used in combination of two or more as necessary.

The breathable patch of the present invention contains glycols such as ethylene glycol and diethylene glycol, olive oil,
Oils and fats such as castor oil and peppermint oil may be blended as an absorption aid.

One of the features of the present invention is that the paste is applied by using a rotary screen printing method, so that the paste and the paste can be applied to the air-permeable support without wasting the support and the paste. It can be applied continuously with a gap in the form of a mesh or a pattern composed of meshes. The size of the mesh of the plaster and the amount of the plaster to be applied are determined by the size of the mesh and the shape of the pattern to be meshed on the rotary cylinder. Therefore, by meshing a mesh and a pattern having a size as required on the rotary cylinder, uniform pores can be ensured on the entire surface of the patch, and a required amount of plaster can be uniformly applied. In addition, since the required amount of the plaster is uniformly applied, the required amount of the medicinal component can be uniformly provided on the entire surface of the patch, and sufficient adhesiveness as the patch can be obtained. At this time, the size of the mesh is 10 to 60
In the case of uniform coating by using a mesh, the amount of plaster applied per square meter can be reduced by a general patch (tape).
The amount of plaster required for the above can be 200 to 20 g. FIG. 1 is a schematic diagram showing a state of a plaster continuously applied with a mesh-like gap on a support.

[0021]

The patch of the present invention has excellent air permeability and remarkably relieves skin respiration and peeling caused by the patch. As a result, long-term use is necessary, especially for chronic diseases,
Continuous (repeated) patching, which was difficult with conventional patches due to the occurrence of skin disorders such as rashes, has been made possible safely. In addition, it has been possible to stably adhere to a place that is easily peeled off in the past, such as the sole of the foot or a finger, for a long time. Further, by employing the rotary screen printing method, the support and the plaster can be used without waste. Hereinafter, the present invention will be described more specifically with reference to examples.

[0022]

EXAMPLES (Example 1) Styrene was used as a raw material for an adhesive.
100 parts by weight of isoprene-styrene block copolymer,
120 parts by weight of an alicyclic saturated hydrocarbon resin and 40 parts by weight of liquid paraffin were charged, and the tank was heated to 160 ° C. and stirred. The raw materials were melted and mixed to obtain an adhesive. 1 adhesive
After cooling to 00 ° C., 20 parts by weight of glycol salicylate and 20 parts by weight of menthol were added and sufficiently stirred to obtain a plaster. Using a rotary screen printing type coating machine equipped with a rotary cylinder having a mesh size of 16 mesh square, the obtained plaster was applied to one side of a breathable nonwoven fabric in a mesh form, and the adhesive was applied. A release paper was stuck on the surface to give a patch. The obtained patch had a plaster weight of 120 g per square meter. In addition, the theoretical contact area of the plaster to the skin was about 50% of that in the case of the whole surface application. FIG. 2 is a schematic diagram showing the arrangement of the plasters applied in a mesh form.

Example 2 A patch of the present invention was obtained in the same manner as in Example 1 except that the size of the stitch of the rotary cylinder was 10 mesh. The obtained patch had a plaster weight per square meter of 200 g.

Example 3 A patch of the present invention was obtained in the same manner as in Example 1 except that the size of the stitch of the rotary cylinder was 60 mesh. The resulting patch had a plaster weight per square meter of 20 g.

Example 4 A patch of the present invention was obtained in the same manner as in Example 1 except that the stitches of the rotary cylinder were circular. FIG. 3 is a schematic view showing the arrangement of the plasters formed in a mesh.

Example 5 A patch of the present invention was obtained in the same manner as in Example 1 except that the stitches of the rotary cylinder were hexagonal. FIG. 4 is a schematic diagram showing the arrangement of the plasters applied in a mesh form.

(Example 6) The patch of the present invention was prepared in the same manner as in Example 1 except that the stitches were pentagonal, and a rotary cylinder processed so that the aggregate pattern formed streaks was used. Obtained. FIG. 5 is a schematic diagram showing the arrangement of the plasters applied in a mesh.

(Comparative Example 1) The plaster obtained in the example was applied to one surface of the same nonwoven fabric as in the example using a doctor knife coater so that the amount of plaster per square meter was 120 g. . A release paper was adhered to the applied adhesive surface to obtain a patch.

Next, the results of tests of the amount of transepidermal water evaporation and the adhesion to skin when the patch of the present invention is used are shown, and the excellent air permeability and adhesiveness of the patch of the present invention are clarified.

(Test Example 1) This test is a measurement of transepidermal water loss. The patches of Example 1 and Comparative Example 1 were stuck on the inner side of the forearm for 30 minutes, and the amount of transdermal water evaporation from the patch surface was measured with a measuring device (tensile tester). As a control, the transepidermal water loss from the unapplied part was measured. FIG. 6 shows the result. As is clear from FIG. 6, Example 1 in which the plaster was applied in a mesh form showed a transepidermal water loss close to that of the control (unapplied portion), as compared with Comparative Example 1 in which the plaster was applied to the entire surface.
It was confirmed that the air permeability was extremely excellent.

(Test Example 2) This test is a measurement of adhesion to skin. The patches of Example 1 and Comparative Example 1 were adhered to the back of a human for 30 minutes, and the resistance when the patches were peeled was measured with a measuring device (tensile testing machine) (n = 5). FIG. 7 shows the result. In Example 1, the adhesive area of Comparative Example 1 was about 50.
Despite being only%, it exhibited comparable skin adhesion to skin.

(Test Example 3) This test is a measurement of the change over time in the adhesive strength to skin. The adhesive patches of Example 1 and Comparative Example 1 were applied to the soles of human feet, and after each time, the adhesive force when peeling the adhesive patches was measured with a measuring device (tensile tester) (n = 5). . FIG. 8 shows the result. The skin adhesive strength of Comparative Example 1 decreased with time, and was peeled off from the application site 24 hours after application. On the other hand, in Example 1, no decrease in the adhesive force over time was observed, and sufficient adhesive force was exhibited even after 24 hours.

[0033]

EFFECT OF THE INVENTION The air-permeable patch of the present invention is characterized in that the plasters applied to the air-permeable support are present in a mesh pattern at intervals.
Extremely breathable. Therefore, obstruction and unevenness of skin respiration are alleviated, skin unevenness is reduced, and skin disorders such as rash are extremely reduced. Therefore, it is a very preferable patch particularly for use in chronic disease patients and the like that need to be repeatedly patched for a long time. Further, the breathable patch of the present invention can be stably stuck for a long time even in a place where it is easily peeled, for example, a sole or a finger. Further, since the air-permeable patch of the present invention is based on the rotary screen printing method, there is no loss of plaster or raw material of the support, and there is no need for a special step for expressing air permeability, so that the production cost is extremely excellent. I have.

[Brief description of the drawings]

FIG. 1 is a schematic view showing a state in which a plaster of a breathable patch of the present invention is applied in a mesh on a support.

FIG. 2 is a schematic diagram showing the arrangement of the plasters applied in a mesh form in Example 1.

FIG. 3 is a schematic diagram showing an arrangement of a plaster applied in a mesh form in Example 4.

FIG. 4 is a schematic view showing an arrangement of a plaster body applied in a mesh form in Example 5.

FIG. 5 is a schematic view showing an arrangement of a plaster applied in a mesh form in Example 6.

FIG. 6 is a graph showing transepidermal water loss in Example 1 and Comparative Example 1.

FIG. 7 is a graph showing the adhesive strength of Example 1 and Comparative Example 1.

FIG. 8 is a graph showing the change over time in the adhesive strength of Example 1 and Comparative Example 1.

[Explanation of symbols]

 1 plaster 2 support 3 gap

Claims (7)

[Claims] 1. A breathable patch, wherein the plaster applied to one surface of the breathable support is present in a mesh form. 2. The breathable patch according to claim 1, wherein the plaster is formed in a pattern consisting of a mesh. 3. The breathable patch according to claim 1, wherein the mesh of the plaster has a circular to polygonal shape. 4. The air-permeable patch according to claim 1, wherein a pattern of the formed mesh is formed in a streak shape. 5. The breathable patch according to claim 1, wherein the mesh size of the plaster is 10 to 60 mesh. 6. The breathable patch according to claim 1, which is used for the sole of the foot or between the toes or toes. 7. A method for producing a breathable patch, comprising applying a plaster on one surface of a breathable support in a mesh or a pattern constituted by a mesh by a rotary screen printing method.