JP2001056325A - Gas chromatograph - Google Patents

Abstract

PROBLEM TO BE SOLVED: To directly compare the outputs of the detectors of a plurality of GCs with each other. SOLUTION: Peak heights Vb, Va at a time when a standard sample is analyzed by one system and other system are inputted from an input part 16. A coefficient calculation part 15 calculates the ratio Va/Vb of both of them to store the same in a coefficient memory 14 as a correction coefficient. At a time of the analysis of an unknown sample, a multiplier 13 multiplies digital data, wherein detection signals are converted, by the correction coefficient to send out the multiplied data to a data processor. By this constitution, the output of detectors are corrected on the basis of the other system.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a gas chromatograph.

[0002]

2. Description of the Related Art FIG. 3 is a block diagram of a general gas chromatograph analysis system. This system is roughly divided into a gas chromatograph apparatus (hereinafter, referred to as "GC") 1 for performing a chromatographic analysis to obtain a detection signal, receiving the detection signal, creating a chromatogram, and further generating the chromatogram. And a data processing device 6 for performing analysis and quantitative analysis.

More specifically, in the GC 1, a sample liquid is heated and vaporized in a sample introduction section 2, and is sent to a column 3 on a carrier gas. The column 3 is controlled at a constant or elevated temperature by a column oven 4, and the sample components are separated in the time direction while passing through the column 3 and reach the outlet. A detector 5 is connected to the outlet of the column 3.
Sequentially detects sample components flowing out of the column 3 and sends out a detection signal to the data processing device 6.

The data processor 6 is a processor dedicated to chromatographic data analysis, or a general-purpose personal computer equipped with a data analysis program. In any case, this data processing device 6
It is configured to include a large-capacity storage device such as a CPU, a ROM, a RAM, a hard disk, and the like. Then, a chromatogram is created, peak analysis of the chromatogram is performed to calculate the content of the sample, and the result is displayed on a screen or printed out.

The interface between the detector 5 and the data processing device 6 may be performed by an analog signal, or may be performed by a digital signal with an A / D converter built in the detector 5. As the detector 5, various types are used depending on the purpose and the type of the target component.
Flame ionization detectors, thermal conductivity detectors, flame photometric detectors and the like. The detector 5 includes an amplifier in order to shape and transmit a minute electric signal as much as possible.
Some have a function such as filtering processing for the purpose of noise reduction and zero point adjustment for the purpose of offset adjustment.

[0006]

As shown in FIG. 4, in a plurality of systems (two units A and B in FIG. 4), even if the same type of detector is used, the electric power of the detecting element is not changed. Characteristics, dimensions, detector gas (make-up gas, etc.)
Of the detector, the purity of the gas, the assembly of the detector, the characteristics of the amplifier, and the like are slightly different, and these differences appear as a machine difference in the output of the detector. For this reason, it is not possible to directly compare the detector outputs between different airframes, or to directly compare chromatograms created based on the detection signals. Therefore, by independently analyzing the standard sample 7 having a known concentration in each of the systems A and B, the correspondence between the output of the detector and the sample concentration (or sample amount) can be determined in the data processing devices 6a and 6b. Prepare a calibration curve as shown below. When an unknown sample is analyzed, the peak area is determined from a chromatogram created based on the output of the detector, and the peak area is calculated based on the calibration curve, and calculated in the respective systems A and B as described above. The sample concentrations are compared with each other.

However, for the purpose of simplifying the quality control of products at a factory, for example, the shapes and the like of chromatograms obtained by different systems are visually compared to determine the identity and similarity. There was a strong desire to make a decision.

The present invention has been made in view of the above points, and a main object of the present invention is to provide a gas chromatograph apparatus capable of directly comparing detector outputs between different instruments. is there.

[0009]

According to the present invention, there is provided a detector for sequentially detecting a sample component flowing out of a column outlet, and a detection signal from the detector is supplied to a data processor. In a gas chromatograph device which sends out and performs various analyses, the detector comprises: a) a conversion means for converting a detection signal into a digital signal; and b) a first detection signal obtained by analyzing a standard sample in the device. A storage unit for storing a correction coefficient based on a difference from a second detection signal obtained by analyzing the same standard sample with another specific same type of device; and c) performing the correction on digital data obtained by the conversion unit. And a multiplying means for multiplying by a coefficient.

[0010] Here, the specific similar device is, for example, a gas chromatograph device of the same model, for which the output of the detector is directly compared with the device. The analysis conditions (for example, column flow rate, etc.) for analyzing the same standard sample with the device and a specific similar device are also prepared.

The correction coefficient is obtained by, for example, obtaining an analysis result of performing a predetermined process on the first and second detection signals in a data processing device connected to the device and a specific similar device, respectively. The analysis results can be given to the detector of the apparatus via input means operated by the operator, and can be obtained by calculation based on both the analysis results. Further, the analysis result obtained based on at least the first detection signal may be received from a data processing device connected to the device through a control signal line.

In this configuration, the correction coefficient is calculated based on the analysis result obtained by analyzing a standard sample with a specific same type of apparatus and the analysis result obtained by analyzing the same standard sample with the same type of apparatus. It is determined to match the analysis result by the device. Therefore, when the same sample is analyzed, the output of the multiplying means coincides with the detection signal of the other specific similar device. Thereby, both can be compared directly.

[0013]

DESCRIPTION OF THE PREFERRED EMBODIMENTS One embodiment of a gas chromatograph according to the present invention will be described below with reference to the drawings. FIG. 1 is a configuration diagram of a detector in a gas chromatograph device according to this embodiment.

As shown in FIG. 1, the output of the detecting element 10 is amplified by an amplifier 11 and converted into digital data at a predetermined sampling rate by an AD converter 12. The multiplier 13 multiplies each digital data by the correction coefficient stored in the coefficient memory 14 and sends it to the data processing device. The input unit 16 includes input keys operated by the operator, and the coefficient calculation unit 15 calculates a correction coefficient based on the data provided from the input unit 16 and stores the correction coefficient in the coefficient memory 14. The detection element 10 differs depending on the type of the detector. For example, the detection element 10 is an element for detecting an ion current in a flame ionization detector, and is a photomultiplier in a flame photometric detector.

Now, as shown in FIG.
The case where the detector output of the system B is corrected based on the system A will be described. First, the standard sample 7 is introduced into each of the systems A and B, and the peak heights of the standard sample on the chromatograms are obtained in the data processing devices 6a and 6b. As will be described later, what is required is the ratio of the peak heights. Therefore, the content of the standard sample 7 may not necessarily be known as long as its components are known. Here, it is assumed that the peak height obtained in the system A is Va, and the peak height obtained in the system B is Vb.

After performing the preliminary analysis as described above, the operator inputs Va and Vb from the input unit 16 of the detector of the chromatographic apparatus 1b of the system B. In response to this input, the coefficient calculator 15 calculates the ratio Va / Vb of the two,
This is stored in the coefficient memory 14 as a correction coefficient k.
For example, if Va = 1 and Vb = 0.8, k = 1.2
It becomes 5. If the correction coefficient has already been stored, it is updated. If the initial value of the correction coefficient k is set to 1 and the correction coefficient can be set to 1 if necessary, the analysis can be performed in the initial state, that is, without such correction. it can.

When an unknown sample is analyzed by the system B, the multiplier 13 multiplies each digital data by the correction coefficient k. Therefore, in the above example, each digital data is multiplied by 1.25. As a result, the difference between the outputs of the detectors of the system A and the system B is eliminated, so that the corresponding peaks on the chromatograms created by the data processing devices 6a and 6b can be directly compared.

FIG. 2 is a diagram showing a configuration of a detector according to another embodiment. As shown in FIG. 2, if the detector 5 is provided with a receiving unit 17 capable of receiving digital data from the data processing device 6, the peak height acquired by the data processing device 6 of the system is transmitted through the receiving unit 17. The peak height obtained by the data processing device 6 of another system can be received through the input unit 16.

It should be noted that the above embodiment is merely an example, and it is apparent that modifications and modifications can be made as appropriate within the spirit of the present invention.

[0020]

As described above, according to the gas chromatograph apparatus according to the present invention, since the difference in output from other devices is corrected in the detector, the results obtained by a plurality of devices can be obtained. Comparison can be made in the state of the chromatogram before performing the quantitative calculation. In addition, there is no need to obtain a calibration curve for each instrument, and the calibration curve obtained by analyzing a standard sample with one system is directly introduced into another system, and quantification is performed using the calibration curve. It is also possible to perform an analysis. For this reason, there is an advantage that even when a plurality of devices are introduced, the labor for creating a calibration curve can be reduced.

[Brief description of the drawings]

FIG. 1 is a configuration diagram of a detector of a gas chromatograph device according to one embodiment of the present invention.

FIG. 2 is a configuration diagram of a detector of a gas chromatograph device according to another embodiment.

FIG. 3 is a configuration diagram of a general gas chromatograph analysis system.

FIG. 4 is a configuration diagram showing an example when a plurality of gas chromatograph analysis systems are used.

[Explanation of symbols]

1, 1a, 1b ... gas chromatograph (GC)
2 ... Sample introduction section 3 ... Column
4: Column oven 5: Detector 6, 6a, 6
b: Data processing device 7: Standard sample 10: Detection element 11: Amplifier 12: AD
Converter 13 Multiplier 14 Coefficient memory 15 Coefficient calculation unit 16 Input unit 17 Receiver

Claims (1)

[Claims] 1. A gas chromatograph apparatus comprising a detector for sequentially detecting a sample component flowing out from a column outlet and transmitting a detection signal from the detector to a data processing device to execute various analyzes, wherein the detector comprises: a) conversion means for converting a detection signal into a digital signal; b) a first detection signal obtained by analyzing a standard sample in the device, and a second detection signal obtained by analyzing the same standard sample in another specific similar device. (2) A gas chromatograph apparatus comprising: a storage unit for storing a correction coefficient based on a difference from a detection signal; and c) a multiplication unit for multiplying the digital data obtained by the conversion unit by the correction coefficient.