JP2001037870A - Manufacture of dialysate, its manufacturing device and prepared liquid tank - Google Patents

Abstract

PROBLEM TO BE SOLVED: To manufacture dialysate sterilely by a dialysate feeder without requiring pre-treatment such as dissolving or thinning prepared liquid, etc. SOLUTION: This method of manufacturing dialysate 6 comprises a process of previously sterilizing agent A adjusted liquid 2 and/or agent B adjusted liquid 5 for sterile storage in a prepared liquid tank 1, a process of sending the agent A adjusted liquid 2, and/or the agent B adjusted liquid 5 to a dialysing fluid feeder 4, and a process of mixingly agitating the agent A adjusted liquid 2 and/or the agent B adjusted liquid 5 at a dialysate feeder 4.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method and an apparatus for producing a dialysate and an improvement in a preparation tank.

[0002]

2. Description of the Related Art A dialysate is prepared by mixing an approximately six types of agent A including sodium chloride and an agent B including sodium bicarbonate as an aqueous solution. When all the compositions of the A agent and the B agent are mixed, a precipitate is deposited. Therefore, the mixture is usually manufactured by dividing the A agent and the B agent immediately before use. FIG. 6 is a schematic diagram of a conventional representative dialysate manufacturing apparatus 31A installed in a dialysis facility. The dialysis fluid manufacturing apparatus 31A includes storage tanks 33 and 38.
, A dissolving tank 36, a dilution tank 39, and a dialysate supply device 34. Agent A is sold as an A agent adjusting liquid 32 in a container of about 9 liters. A preparation liquid 32
The lid 47 of the storage tank 33 for 100 to 200 liters is opened and transferred. A certain amount of A is stored in the storage tank 33.
The agent adjustment liquid 32 is transferred to the dialysate supply device 34 via the storage pipe 48. The B agent is in the form of a powder, and the B agent and sterile water are placed in a dissolution tank 36 and dissolved to produce an aqueous solution B agent 37, which is transferred to the storage tank 38 via the pipe 48a. Inspection of the concentration of the aqueous solution 37 of the agent B in the storage tank 38 and the like are sent to the dilution tank 39 via the pipe 48b. Sterile water 40 is added to the B agent aqueous solution 37 in the dilution tank 39 via a pipe 48e to adjust and stir the B agent adjusting solution 35, and then sent to the dialysate supply device 34 via a pipe 48c. At the same time, the A agent adjusting liquid 32 in the storage tank 33
8 to the dialysate supply device 34. Pipe 48, 4
Pumps (not shown) for 8a, 48b, 48c and 48e
Is used during liquid transfer. The A agent adjustment liquid 32 and the B agent adjustment liquid 35 are mixed and stirred in the dialysate supply device 34 to produce a dialysate 46. The dialysate 46 is supplied to each dialyzer 7 via a pipe 48d by operating a pump (not shown) mounted on the dialysate supply device 34 or a pump (not shown) mounted on a pipe 48d.

There are two types of liquids A and B in liquids and powders.
Each has the following advantages and disadvantages.Advantages of liquid  ・ The A agent adjustment liquid 32 in the container is stored in the storage tank 33 as it is.
It can be transferred and placed.Disadvantages of liquid  ・ Because of the weight, it takes time and effort to transport and requires labor.・ Various bacteria may occur when the A agent adjusting liquid 32 is put into the storage tank 33.
Easy to mix.Advantages of powder  ・ Easy transportation. -In the case of an automated lysis system, it is difficult for bacteria to enter.Disadvantages of powder  ・ A melting device is required.・ Particles may be fine.
May prevent suction. The inventor has diligently studied to mitigate the disadvantages of liquids and powders
As a result, the following invention was reached.

[0004]

Means for Solving the Problems [1] The present invention relates to a preparation liquid tank 1 provided with a connector 13 of a pipe 8 (8a) communicating with a dialysate supply device 4 and a connection portion 3 detachably formed on a side wall. I will provide a. [2] The present invention relates to a pipe 8
The adjustment liquid tank 1a provided with the connection member 19 formed so that (8a) is detachable is provided. [3] The present invention provides the adjustment liquid tank 1 (1a) according to [1] or [2], in which the moving member 9 is provided at the bottom. [4] The present invention relates to at least the agent A preparation liquid 2 and / or B
An apparatus 1A for producing a dialysate 6 comprising a preparation liquid tank 1 (1a) containing an agent preparation liquid 5 and a dialysate supply device 4 is provided. [5] The present invention provides a method for producing a dialysate including the following steps. (1) a step of sterilizing the A agent adjustment liquid 2 and / or the B agent adjustment liquid 5 in advance and storing them in the adjustment liquid tank 1 (1a) under aseptic conditions; (2) in the preparation liquid tank 1 (1a) A step of sending the A agent adjustment liquid 2 and / or B agent adjustment liquid 5 that has entered to the dialysate supply device 4; (3) sending the A agent adjustment solution 2 and / or the B agent adjustment solution 5 to the dialysate supply device 4; Mix and stir with dialysate 6
Manufacturing process,

[0005]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS FIG. 1 is a schematic view showing an example of a dialysis fluid producing apparatus 1A according to the present invention, which is installed in a dialysis facility. Further, a flow of sending the manufactured dialysate 6 to each dialyzer 7 is shown. The dialysis fluid manufacturing apparatus 1A includes a dialysis fluid supply device 4 and a conditioned fluid tank 1 containing an A formulation fluid 2 and a B formulation fluid 5. The preparation liquid A 1 and the preparation B liquid 5 are sterilized in advance, and the adjusted liquid tank 1 is prepared in a state where the concentration and the like are adjusted.
It is stored in an aseptic state (a later-described adjustment liquid tank 1a). That is, when the dialysate is adjusted in the adjustment liquid tank 1, contamination of various bacteria is reduced as much as possible. The adjustment liquid tank 1 has a pipe 8 connected to a side wall of a dialysate supply device 4 which will be described later.
The connector 13 attached to the tip of (8a) is connected to the detachable connection part 3, and the A agent adjustment liquid 2 and the B agent adjustment liquid 5 are sent to the dialysate supply device 4. A preparation liquid 2
The B preparation liquid 5 is mixed and stirred in the dialysate supply device 4 to produce a dialysate 6. The dialysate 6 is sent to each dialyzer 7 via a pipe 8b. A moving member 9 is provided at the bottom of the adjustment liquid tank 1 (an adjustment liquid tank 1a to be described later). In the present invention, the moving member 9 may be a wheel or a rail as shown, and in short, any member can be used as long as the adjusting liquid tank 1 (1a) can be easily moved. An air vent (not shown) similar to FIG. 5 described later is mounted on the top surface of the adjustment liquid tank 1. When the A and B agent adjustment liquids in the adjustment liquid tank 1 (1a) are sent to the dialysate supply device 4 via the pipe 8 (8a), air is sent from the air vent into the adjustment liquid tank 1 and the pipe 8 The pump 27 provided in (8a) is operated to feed the liquid. When the dialysate 6 is sent from the dialysate supply device 4 to the dialyser 7 via the pipe 8b, the dialysate is sent by a pump attached to the dialysate supply device 4 or a pump attached to the pipe 8b.

FIG. 2 shows a connecting portion 3 mounted on the adjustment liquid tank 1.
FIG. 3 is an enlarged view of the connector 13 attached to the pipe 8 (8a) communicating with the dialysis fluid supply device 4, and FIG. 3 is a schematic view when the connection portion 3 and the connector 13 are attached. Connection part 3
Is mounted on the side wall (lower outer wall surface) of the adjustment liquid tank 1, and a cap (not shown) is mounted. When using, remove the cap, disinfect the insertion port 15 and the insertion portion of the connector 13 with alcohol, and remove the connector 13 in the direction of the arrow.
Insert In order to separate the connector 3 from the attached connection part 3, the valve 12 of the pipe 8 (8 a) is closed, the ring 14 on the outer periphery of the insertion port 15 of the connection part 3 is pinched by a finger, and the connection part 3 is pushed in the root direction. The connector 13 and the connector 13 are automatically disengaged by the recoil of a spring 26 mounted inside the rear part of the connection portion 3. A stop valve 25 is provided substantially in the middle of the connection portion 3.
Is installed, and even if the A agent adjustment liquid 2 and the B agent adjustment liquid 5 are contained in the adjustment liquid tank 1, the liquid does not leak from the insertion port 15. Therefore, by inserting the connector 13 into the insertion port 15 and connecting the same, the A agent adjustment liquid 2 and the B agent adjustment liquid 5 in the adjustment liquid tank 1 are sent to the dialysate supply device 4 through the pipe 8 (8a). .

After the dialysate 6 is supplied to each of the dialysers 7 and the operation is completed, the adjusting liquid tank 1 is cut off from the pipe 8 (8a). After the separation, cleaning and disinfection are performed to prevent adhesion of various bacteria in the pipe 8 (8a), the dialysate supply device 4, and the pipe 8b. When the dialysate 6 is newly manufactured by the dialysate supply device 4, the conditioned liquid tank 1 that has been emptied is exchanged, and the connection portion 3 of the new conditioned liquid tank 1 and the pipe 8 (8
The connector 13 of a) is attached.

FIG. 4 (a) is a schematic view of a regulating liquid tank 1a according to another embodiment of the present invention, FIG. 4 (b) is a sectional view of the mounting of the charging port 10 and the lid 17, and FIG. FIG. 6 is a cross-sectional view when a connecting member 19 is mounted on the rim. When the solution A and the solution B are put in the preparation liquid tank 1a, the lid 17 is attached to the inlet 10. That is, in the adjustment liquid tank 1a, contamination of various germs is reduced as much as possible when adjusting the dialysate. The connection member 19 includes the lid 16 and a screw 22 a for fixing the lid 16 to the insertion port 10. The lid 16 is provided with a pipe mounting portion 18 for fixing the pipe 8 (8a) and the air vent 2.
4 is provided with a connecting pipe 24a protruding therefrom. The pipe mounting portion 18 includes a screw 22 and a screw receiving portion 2 that is screwed thereto.
3, the middle part of the inner circumference of the screw 22 and the screw receiving part 2
Ring-shaped pressing portion 21 arranged over the inner periphery of the upper part 3
It is composed of The pipe 8 (8a) is fixed to the adjustment liquid tank 1a as follows. The tip is passed through the ring-shaped pressing member 21 via the screw 22 of the pipe mounting portion 18 so that the tip of the pipe 8 (8a) passes through the lid 16 so that a gap is slightly opened from the bottom of the adjustment liquid tank 1a. Adjustment liquid tank 1
a, and is fixed by tightening the screw 22 so that the pressing portion 21 is in close contact with the outer periphery of the pipe 8 (8a). Further, the screw 22a is screwed into a screw receiving portion 23a formed on the outer periphery of the insertion port 10. Connection pipe 2 of the lid 16
Air is fed into the adjustment liquid tank 1a through an air vent 24 connected to the adjustment liquid tank 4a, and a pump 27 is operated to operate the A agent adjustment liquid 2 and the B agent adjustment liquid 5 in the adjustment liquid tank 1a.
And the dialysate supply device 4 is sucked through the pipe 8 (8a).
Send to

The order in which the pipes 8 (8a) are mounted on the pipe mounting portion 18 when the connecting member 19 is mounted on the inlet 10 is not particularly limited. After inserting the pipe 8 (8a) into the pipe mounting portion 18 provided on the lid 16 as described above, the screw 22a mounted on the lid 16 may be screwed into the screw receiving portion 23a. The cover 8 may be screwed into a screw receiving portion 23a via a screw 22a, and then the pipe 8 (8a) may be mounted on a pipe mounting portion 18 provided on the cover 16. Although the lid 16 and the screw 22a are formed separately in the connecting member 19 in FIG. 5, they may be formed integrally.

The A agent adjusting liquid 2 is contained in the adjusting liquid tank 1 (1a).
The method of storing the B agent adjustment liquid 5 and the B agent adjustment liquid 5 is not limited to only the method of sterilizing the A agent adjustment liquid 2 and the B agent adjustment liquid 5 and storing them in the adjustment liquid tank 1 (1a) under aseptic conditions. The A agent adjustment liquid 2 and the B agent adjustment liquid may be put in the tank 1 (1a) and sterilized to adjust the concentration.
It is sufficient that (1a) is sterilized, and the A agent adjustment liquid 2 and the B agent adjustment liquid 5 are sterile and their concentration is adjusted.

The above is a method of adjusting the dialysate by mixing the liquid A and the liquid B adjustment liquids. When the dialysate is prepared from the liquid and the powdered liquid A and the liquid B, for example, Liquid A
Preparation agent 1 (or B agent) as described above, tank 1 (1a)
From the diluting tank 39 to the dialysate supply device 4 and adjust the powder B agent (or agent A) in the same manner as in FIG. ,
Stirring can produce a dialysate.

The dialysate supply device 4 is provided with a discharge port 11 so that the dialysate 6 rejected by a concentration test or the like can be discharged. Valves 12 are provided for pipes 8, 8a and 8b.
And a microfiltration filter (not shown), and the valve 12 is provided with the A agent, the B agent adjustment liquids 2 and 5 sent from the adjustment liquid tank 1 (1a) to the dialysate supply apparatus 4, and the dialysate supply apparatus 4 Is used to open and close the flow path when the dialysate 6 is sent to each dialysate 7. Microfiltration filter (not shown)
This is also attached to remove foreign substances and germs from the A agent, the B agent adjusting liquids 2 and 5 and the dialysate 6 flowing through the flow path.

[0013]

The preparation liquid A 2 and the preparation B liquid 5 are sterilized in advance, their concentrations and the like are adjusted and stored aseptically in the preparation liquid tank 1 (1a). ) Is detachable from the pipe 8 (8a) communicating with the dialysate adjusting device 4, so that pretreatment such as dissolution or dilution of the A agent preparation solution 2 and the B agent preparation solution 5 is not required, and the dialysis solution is further reduced. The dialysate 6 can be aseptically produced by the supply device 4.

[Brief description of the drawings]

FIG. 1 is a schematic diagram of an apparatus 1A for producing a dialysate according to the present invention.

FIG. 2 shows a connection portion 3 of the adjustment liquid tank 1 and a pipe 8 (8a).
Enlarged view of connector 13 attached to the tip of

FIG. 3 is a schematic diagram in which a connector 13 is attached to a connection portion 3;

FIG. 4 is a schematic view of a preparation liquid tank 1a (a) and a cross-sectional view in which a lid 17 is attached to an inlet 10 (b).

FIG. 5 is a schematic diagram in which a connecting member 19 is attached to the inlet 10;

FIG. 6 is a schematic diagram of a conventional dialysate manufacturing apparatus 31A.

[Explanation of symbols]

 1A, 31A dialysate manufacturing apparatus 1, 1a adjustment liquid tank 2, 32 agent A adjustment liquid 3 connection part 4, 34 dialysate supply apparatus 5, 35 agent B adjustment liquid 6, 46 dialysate 7 dialyzer 8, 8a, 8b pipe 48, 48a, 48b pipe 48c, 48d, 48e pipe 9 moving member 10 input port 11, 41 discharge port 12, 42 valve 13 connector 14 ring 15 insertion port 16 lid 17, 47 lid 18 pipe mounting portion 19 connection member Reference Signs List 21 pressing member 22, 22a screw 23, 23a screw receiving portion 24 air vent 24a connection pipe 25 stop valve 26 spring 27 pump 33, 38 storage tank 36 dissolution tank 37 B agent aqueous solution 39 dilution tank 40 sterile water

Claims (5)

[Claims] 1. A preparation liquid tank 1 characterized in that a connector 13 of a pipe 8 (8a) communicating with a dialysate supply device 4 and a connection portion 3 formed detachably are mounted on a side wall. 2. A pipe 8 (8) is inserted into an input port 10 provided on the top surface.
An adjustment liquid tank 1a, wherein a connection member 19 formed so as to be detachable from a) is disposed. 3. The adjusting liquid tank 1 according to claim 1, wherein the moving member 9 is provided at a bottom portion.
a). 4. An apparatus 1A for producing a dialysate 6 comprising a preparation liquid tank 1 (1a) containing at least a preparation A preparation liquid 2 and / or a preparation B preparation liquid 5 and a dialysate supply device 4. 5. A method for producing a dialysate, comprising the following steps: (1) a step of sterilizing the A agent adjustment liquid 2 and / or the B agent adjustment liquid 5 in advance and storing them in the adjustment liquid tank 1 (1a) under aseptic conditions; (2) in the preparation liquid tank 1 (1a) A step of sending the A agent adjustment liquid 2 and / or B agent adjustment liquid 5 that has entered to the dialysate supply device 4; (3) sending the A agent adjustment solution 2 and / or the B agent adjustment solution 5 to the dialysate supply device 4; Mix and stir with dialysate 6
Manufacturing process,