JP2001029451A - Antibacterial urethral catheter and manufacture of the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To keep the antibacterial performance not only in an intial period but for a long period by forming a coating layer including a compound bondable to antibacterial agent on a surface of an urethral catheter, and then introducing a silver compound to the surface by means of an aqueous solution of a water soluble silver compound. SOLUTION: An antibacterial urethral catheter is manufactured by forming a coating layer including a compound bondable to antibacterial agent, on a surface of an urethral catheter, and then introducing a silver compound on the surface by means of an aqueous solution of a water soluble silver compound. By dividing the manufacturing process into two, that is, a process for introducing the compound bondable to the antibacterival agent to the urethral catheter and a process for introducing the silver compound to the surface by means of the aqueous solution of the water soluble silver compound, in particular, by executing the first process for introducing the compound bondable to the antibacterial agent to the urethral catheter, by the coating, high antibacterial activity can be obtained with high reproducibility, and the unevenness of the appearance and the crocking of the catheter after the antibacterial treatment can be prevented.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an antimicrobial urinary catheter having a long-lasting antimicrobial activity and a method for producing the same. More specifically, for a long period of time after indwelling in the body, a coating layer containing a compound capable of binding to silver ions is formed on the surface of the catheter after molding the antibacterial urinary catheter and the catheter that maintain high antibacterial activity, and the compound contains a silver compound. The present invention relates to a method for producing an antimicrobial urinary catheter in which a silver compound is introduced into the surface of a catheter mainly by binding by an ionic bond.

[0002]

2. Description of the Related Art Urinary catheters, which are one type of medical device to be placed in a living body, have been disinfected, sterilized, and used in some manner prior to use. However, in many cases, the catheter is used for a long period of time, and sterility of the urinary catheter itself is often not maintained during use. Therefore, improvement is desired. The reason that the sterility is not maintained is that bacteria invade from the outside through the lumen of the catheter and cause infections such as urethritis, cystitis and pyelonephritis.

[0003] As a conventional measure for preventing infectious diseases, chemotherapy for prophylactic administration of antibiotics and the like has been performed. However, in this method, since the antibiotic is administered in a large amount, the problem of side effects cannot be avoided depending on the type of the antibiotic. Also, once infected, the bacteria are temporarily eliminated by chemotherapy, but there is a problem in easy chemotherapy since re-infection is likely to occur due to the emergence of resistant bacteria thereafter.

[0004] As the most effective measure, there is a method of imparting antibacterial properties to the entire urinary catheter or the surface thereof.

[0005] Typical antibacterial substances include gold, silver, copper,
There are heavy metals such as zinc and their metal compounds. These are bacteria, even in very small amounts in the form of metal ions.
It has a broad antibacterial spectrum against fungi. Up to now, attempts have been made to manufacture urinary catheters containing these metal compounds in a matrix to impart antibacterial properties.

A method disclosed in Japanese Patent Publication No. 6-34817 is one in which a silver-based antibacterial substance is applied to a urinary catheter. Here, a method of forming a urinary catheter coated with a latex containing silver protein is described.

[0007] In addition to the above-mentioned metal compounds, compounds having antibacterial properties include quaternary ammonium salts, which are one of cationic antibacterial substances. Since these compounds also show strong antibacterial activity against bacteria, attempts have been made to use them in urinary catheters which are contained in a matrix as in metal compounds to impart antibacterial properties.

[0008] Japanese Patent Publication No. 3-64143 discloses a urinary catheter containing a cationic antibacterial substance. In this method, a poorly water-soluble quaternary ammonium salt is contained on the surface of a urinary catheter.

When a compound having a strong antibacterial property against bacteria, such as protein silver or a quaternary ammonium salt, is dispersed in various latexes and processed, a stable dispersion state is maintained in the latex for a long period of time. It is difficult to coagulate latex particles and sedimentation of antibacterial substances (especially metal compounds), which causes unevenness of the coating layer, darkening of the appearance of the catheter, and deterioration of the stability of the catheter.

According to our studies, currently available antimicrobial urinary catheters which are commercially available exhibit weak antibacterial activity or bacteriostatic action immediately after use, but are supposed to be left in the body for a long time.
The catheters extracted with saline for 1 to 2 weeks show no antibacterial activity or even bacteriostatic activity, satisfying the clinical requirements for their strength and persistence. It was not something.

On the other hand, we have been studying the provision of an antibacterial activity to a urinary catheter (Japanese Unexamined Patent Publication No. Hei 11-1999).
9681, JP-A-11-47260). That is, by introducing the antibacterial agent into the catheter after molding, and distributing the antibacterial agent on the catheter surface, a high antibacterial activity can be obtained with a small amount of the antibacterial agent.

However, although the antimicrobial urinary catheter obtained by this method has a high antimicrobial activity at the initial stage, it has low persistence, cannot obtain high antimicrobial activity with good reproducibility, and has a catheter after antimicrobial treatment. However, there is a drawback that appearance unevenness and discoloration often occur, and in particular, the above-mentioned problem is remarkable in a silicone catheter.

[0013]

SUMMARY OF THE INVENTION The present invention provides an antimicrobial urinary catheter which satisfies the characteristics required in clinical use, and a method for stabilizing such an antimicrobial urinary catheter stably and on all substrates. To provide a manufacturing method that can be reproduced well.

[0014]

That is, the present invention is as follows. A method for producing an antimicrobial urinary catheter, comprising: forming a coating layer containing a compound capable of binding to an antimicrobial agent on the surface of a urinary catheter, and introducing the silver compound to the surface with an aqueous solution of a water-soluble silver compound. The method for producing an antimicrobial urinary catheter described above, wherein the silicone composition is contained in a coating layer containing a compound capable of binding to an antimicrobial agent. The method for producing an antimicrobial urinary catheter according to the above or the above, wherein the antimicrobial agent is at least one selected from silver nitrate, silver acetate, and silver perchlorate. The method for producing an antimicrobial urinary catheter according to any one of claims 1 to 3, wherein the compound capable of binding to the antimicrobial agent is at least one selected from amino acids, amino acid oligomers, amino acid polymers and amino acid derivatives. The method for producing an antimicrobial urinary catheter according to any one of the above-mentioned items, wherein the compound capable of binding to the antimicrobial agent is an anionic surfactant. The method for producing an antimicrobial urinary catheter according to any one of claims 1 to 3, wherein the compound capable of binding to the antimicrobial agent is at least one selected from a compound having a carboxyl group and a compound having a sulfonic acid group. An antibacterial urinary catheter obtained by the above-mentioned manufacturing method.

That is, the present invention is carried out in two steps: a step of introducing a compound capable of binding to an antibacterial agent into a urinary catheter, and a step of subsequently introducing a silver compound to the surface with an aqueous solution of a water-soluble silver compound. The first step is a method for producing an antimicrobial urinary catheter, wherein the compound capable of binding to the antimicrobial agent is introduced by a coating solution containing the compound.

As described in the section of the prior art, by introducing an antibacterial agent into a molded catheter, the antibacterial agent is distributed on the catheter surface, thereby obtaining a high antibacterial activity with a small amount of the antibacterial agent. Although the performance of the antimicrobial urinary catheter obtained by this method has high antimicrobial activity in the initial stage, it is low in persistence, and that high antimicrobial activity cannot be reproducibly obtained, There were problems such as uneven appearance and discoloration of the catheter.

However, the step of introducing a compound capable of binding to an antibacterial agent into a urinary catheter and the subsequent step of introducing a silver compound to the surface with an aqueous solution of a water-soluble silver compound are divided into two steps. By performing the step of introducing a compound capable of binding to an antibacterial agent into a urinary catheter by coating, high antibacterial activity can be obtained with good reproducibility, and unevenness and discoloration of the appearance of the catheter after the antibacterial treatment can be avoided.

The surface of the catheter to be coated can be either internal or external, or both internal and external, depending on the intended use.

Further, by selecting a coating liquid composition used for coating the catheter surface, an antibacterial agent can be bonded to the surface of any substrate.

The coating liquid may be a compound of the same type or a different composition as that of the base material as long as the coating layer hardly peels off, but natural rubber, silicone rubber, synthetic rubber and the like generally used as a catheter base material are used. Coating is easy, safety is high,
A silicone composition such as silicone oil, silicone rubber, silicone adhesive or the like is preferred because of the smoothness of the surface after coating.

The silicon composition is mixed with a compound capable of binding to silver ions, if necessary, in the presence of a suitable solvent, coated in this state, and then polymerized by condensation or addition of an effect agent. It is preferable to adopt a method of crosslinking and curing.

Due to the easiness of handling, among such silicon compositions, one-part RTV (Room Temperature) which cures while reacting with moisture in the air.
reVulcanizing rubber is preferred. Among them, a deacetone-curing type and a dealcohol-curing type, which hardly cause offensive odor and corrosiveness, harden quickly, and have relatively good adhesion to other structures, are preferable.

The base material of the antimicrobial urinary catheter of the present invention may be any material having properties suitable for a urinary catheter. Examples of the base material of a general urinary catheter include natural rubber, synthetic rubber, silicone rubber, and other organic polymers.

Natural rubber is a material which is inexpensive and has excellent mechanical properties. When used for medical equipment, it is important to use a sufficiently purified latex to remove allergic substances contained in raw materials, and to perform sufficient leaching during molding and processing. The safety of various chemicals must be carefully considered.

For example, natural rubber latex as a raw material includes:
The use of a deproteinized natural rubber latex which has been purified to a high purity and from which dissolved proteins have been removed as disclosed in JP-A-6-56902 can prevent allergic reactions due to proteins.

Examples of the synthetic rubber include homopolymers or copolymers of vinyl monomers such as ethylene, styrene, vinyl acetate, vinyl chloride, vinylidene chloride and acrylonitrile, butadiene, isoprene, chloroprene, 1,3-pentadiene, and the like. A homopolymer or copolymer of a diene monomer such as 1,5-hexadiene,
Copolymers of the above vinyl monomers and diene monomers are mentioned.

Examples of the silicone rubber include dimethylpolysiloxane, methylphenylpolysiloxane, methylvinylpolysiloxane, and fluoroalkylmethylpolysiloxane.

Further, as long as the silicon composition is contained as one of the components, it may be a blend with another polymer material. Examples of the base component other than the silicon composition include polyvinyl halide, polyvinylidene halide, polyurethane, polyurethane urea, polyester, polyamide, polypropylene, polyethylene and the like. When a blend-type substrate is used, the content of the silicon composition is preferably 20% to 100%, more preferably 40% to 100%.

Other organic polymers include polyurethane and polyurethane urea.

The compounds capable of binding to silver ions used in the antimicrobial urinary catheter of the present invention are amino acids, amino acid oligomers, amino acid polymers, and amino acid derivatives. You may use simultaneously. Here, the amino acid oligomer means one having 2 to 10 amino acid residues. Also,
The amino acid polymer refers to a polymer having 11 or more amino acid residues, preferably having 11 to 500 amino acid residues, and more preferably having 11 to 200 amino acid residues. Specific examples include sodium poly-L-glutamate and the like. Further, an amino acid derivative is a compound in which a part of an amino acid is bonded to another compound, and examples thereof include sodium stearoyl-L-glutamate.

The compound capable of binding to silver ions used in the antimicrobial urinary catheter of the present invention is an anionic surfactant, such as sulfonic acid surfactants, alkylbenzene sulfonates, alkyl sulfonates, and alkylnaphthalenes. Sulfonates and the like. The alkyl group suitably has 6 to 20 carbon atoms. Of these compounds, only one type may be used, or two or more types may be used simultaneously.

The compound capable of binding to silver ions used for the base material of the antimicrobial urinary catheter of the present invention is a compound having a carboxyl group and a compound having a sulfone group, such as taurine, glutathione, sulfadiazine and a compound having 6 carbon atoms. And -40 saturated or unsaturated monovalent or polyvalent carboxylic acids.

The method of introducing a compound capable of binding to silver ions into a substrate is carried out by using a coating solution containing a compound capable of binding to silver ions.

The coating of the above-mentioned compound capable of binding to silver ions onto a substrate is carried out by immersing a urinary catheter in a coating solution containing the above compound and coating it.

The above compound in the coating solution may be completely dissolved in the coating solution or may be in a dispersed state, and the concentration is preferably in the range of 0.0001 to 50% by weight. More preferably, it is 0.001 to 30% by weight. Although the immersion temperature is related to the stability of the compound,
00 ° C is preferable, and more preferably 20 to 80 ° C. The immersion time is from a few seconds to 3 minutes, depending on the temperature.
More preferably, it is 3 seconds to 1 minute.

The composition of the coating solution depends on the catheter substrate to be coated.
The one that is difficult to peel is good. In particular, in the case of a balloon catheter, the material must be resistant to balloon inflation.

In the present invention, the step of introducing the silver compound into the antimicrobial urinary catheter is performed after coating the compound capable of binding to the antimicrobial agent.

The antibacterial substance used in the antibacterial urinary catheter of the present invention is characterized in that it is a silver compound. Since the silver compound has good solubility in a solvent and high reactivity because of its low molecular weight, silver nitrate, silver acetate,
It is preferably one of silver perchlorate.

The processing conditions of the silver compound to be processed into the antibacterial urinary catheter vary depending on the kind and combination, but in the present invention, an aqueous solution of the silver compound of 0.0001 to 5% by weight is used. More preferably 0.001 to
A 0.5% by weight aqueous solution is used. In this case 0.00
When the amount is less than 01% by weight, a sufficient amount of the silver compound does not bind to the catheter, and when the amount is more than 5% by weight, the silver compound may not be sufficiently dissolved. The immersion condition of the urinary catheter in the aqueous silver compound solution is not limited as long as it does not adversely affect the base material, the compound capable of binding to silver ions, and the silver compound, but the immersion time is preferably 0.1 to 48 hours. , More preferably 1 to 24 hours. The immersion temperature of the urinary catheter in the aqueous silver compound solution is 30 to 120 ° C.
And more preferably 40 to 100 ° C. In this case, it is preferable to shake.

In the antimicrobial urinary catheter obtained by the above-described steps, it is not necessary to consider the dispersibility of the base material and the silver compound as the antimicrobial substance, and the antimicrobial imparting step is performed under mild processing conditions. Processing is easy because it can be performed.

The silver compound introduced into the antimicrobial urinary catheter of the present invention has a coating layer containing a compound that can bind to the silver compound before the introduction.
Since silver, which is an antibacterial agent, is localized on the catheter surface, the performance is maintained for a long time after placement.

As described above, the antibacterial urinary catheter of the present invention can introduce a silver compound into the surface of the catheter more efficiently than a conventional antibacterial urinary catheter.

Since the urinary catheter generally has an indwelling period in the body for one to two weeks, the antibacterial activity preferably lasts for one week, more preferably two weeks.
Although it is difficult to evaluate the strength of the antibacterial activity clinically, we have already disclosed in JP-A-11-9 / 1999.
681 and Japanese Patent Application Laid-Open No. 11-47260 disclose the evaluation method. As an antibacterial activity of the antimicrobial urinary catheter, the number of viable bacteria is measured after immersion in a Pseudomonas aeruginosa suspension at 37 ° C for 24 hours. The viable cell count when used as a blank is 10 ⁷ cells /
ml order. 1 × 1 viable bacteria in the initial suspension
Since it is 0 ⁵ cells / ml, if it is 1 × 10 ⁶ cells / ml or less, it has a bacteriostatic action (does not increase the number of bacteria) and 1 × 10 ⁶ cells / ml.
If it is ⁴ / ml or less, it can be determined that it has an antibacterial effect. Since the detection limit of the viable cell count in this method is 10 / ml, the viable cell count having the strongest antibacterial activity is 10 / ml.
It is displayed as “unit / ml” or less.

In addition, since the onset rate and onset time of infectious diseases vary greatly depending on the condition of the patient and the surrounding environment, it is difficult to evaluate the persistence of the antibacterial activity clinically.
Therefore, we extracted the antimicrobial urinary catheter with physiological saline, which was an alternative method for clinical use.
That is, the operation of extracting with 2.5 ml of physiological saline per 1 cm ^{2 of} surface area was regarded as the state of indwelling in the body, and the duration of the antibacterial activity was evaluated by changing the extraction time. Further, in order to make the dissolution behavior of the antibacterial agent less affected by the concentration of the antibacterial agent in the extract, the extraction of the physiological saline was performed once for 24 hours.
The extract was changed every hour, and the number of changes was regarded as the number of days of indwelling in the body. If the number of extractions is one, it is left for one day,
Seven times means that the patient was placed in the body for one week.

As a result of our investigation to satisfy the required characteristics of the antimicrobial urinary catheter during clinical use,
In order to have a bacteriostatic effect after a week, the operation of extracting with physiological saline of 2.5 ml per 1 cm ^{2 of} surface area at 37 ° C. for 24 hours is repeated 7 times, washed with water, dried, and then subjected to an EOG sterilized antibacterial urinary catheter. It was immersed in a Pseudomonas aeruginosa (IFO13275) suspension having a viable cell concentration of 1 × 10 ⁵ cells / ml at a rate of 5 ml / cm ² with a Prose solution diluted 50-fold with physiological saline at a rate of 5 ml / cm ² , at 37 ° C. for 24 hours. If the number of viable bacteria in the immersion liquid after shaking culture is 1 × 10 ⁶ / ml or less for any of the 7 extraction procedures using physiological saline, sufficient antibacterial activity is maintained even after indwelling for 1 week. And preferred. Extraction operation 7
If the number of viable bacteria per catheter is more than 1 × 10 ⁶ , the antibacterial activity is not sufficient, or even if it has a high antibacterial activity in the beginning, its persistence is insufficient, and the antibacterial activity after one week indwelling It is not preferable because of low risk of clinical infection. Further, it is more preferable that the concentration is 1 × 10 ⁶ cells / ml or less even at the 14th extraction operation because it has a bacteriostatic action even after incubating for 2 weeks. After repeating the operation for extracting the number of viable bacteria, 1 × 10
^It is particularly preferable that the concentration be kept at ⁴ cells / ml or less, particularly 4 × 10 ² cells / ml or less, since it has strong antibacterial activity and the risk of infection is further reduced.

Here, the water washing after the extraction of the physiological saline is for completely removing the physiological saline in which the antibacterial agent is eluted, and is not particularly limited as long as it is a method meeting this purpose. Immersion for several minutes.

The drying after washing with water is for drying attached water, and is not particularly limited as long as it does not deteriorate the material of the catheter. For example, drying at 70 ° C. for 2 hours can be mentioned. Can be

Further, even if the treatment is carried out in an aseptic condition, it is preferable to subject the catheter after drying to sterilization, since the subsequent culture is affected, and the sterilization treatment should be performed using EOG, gamma ray, high-pressure steam sterilization or the like. But E
OG sterilization is preferred because it can be easily operated.

The preparation of a Pseudomonas aeruginosa suspension is a common-sense technique as long as the person is familiar with the technology, and it is considered that the reproducibility and quantitativeness of the data are established. This will be described below just in case.

All the instruments used for the culturing operation are sterilized by any of autoclave sterilization, dry heat sterilization, and EOG sterilization. In addition, broth and physiological saline are used after sterilization in an autoclave.

A broth solution obtained by dissolving P. aeruginosa chilled and stored in a slant in a prescribed volume of dried broth made by Nissui 5
Inoculate one platinum loop into 0 ml and place in a 37 ° C incubator for 2 minutes.
Incubate for 4 hours. Since about 10 ⁷ viable cells / ml exist in the cell suspension after culturing,
Dilute with saline to the desired concentration.

The viable cell count was measured by applying a predetermined amount to a petri dish filled with a normal agar medium (manufactured by Nissui),
It is calculated by counting the number of colonies after culture for a period of time.

Since the antimicrobial urinary catheter of the present invention has sufficiently high antimicrobial activity and its durability for clinical use, it reduces the risk of infection even when the indwelling period is long. The antimicrobial urinary catheter can be manufactured using any of the currently known methods, and as a result of our studies, can be suitably manufactured by the following method.

Hereinafter, the present invention will be described with reference to examples.
The present invention is not particularly limited by the examples.

Example 1 0.5 part of 2-mercaptobenzothiazole zinc salt, 1.5 parts of colloidal sulfur, and 1.0 part of active zinc were added to 100 parts of anionic styrene-butadiene copolymer latex having a solid content of 50%. And 1.0 part of stearic acid were added to prepare a synthetic rubber latex solution. The pH of the synthetic rubber latex solution was 10.5.

Next, the immersion mold for urinary catheter was immersed in the above synthetic rubber latex solution and dried (80 ° C., 10 minutes) to obtain a catheter repeatedly until the thickness became 1.6 mm. 5% silicone adhesive (Shin-Etsu Chemical Co., Ltd.)
KE3479) A solution prepared by dispersing 10% sodium stearate with respect to the adhesive in a THF solution was prepared, and the catheter was removed from the mold for 20 seconds, dried at 50 ° C for 5 hours, and contained sodium stearate. A coating layer was created. It was further immersed in a 0.1% aqueous solution of silver nitrate and shaken at 80 ° C. for 2 hours. The urinary catheter was washed with running water for 2 days and dried at 60 ° C. for 10 hours to obtain an antibacterial urinary catheter.

The above antibacterial catheter was placed in physiological saline 15
It was immersed in 0 ml and infiltrated at 37 ° C. The saline solution of the immersion liquid was changed every day.

The above antibacterial urinary catheter (extracted with physiological saline for 0 days, 3 days, and 7 days and washed with running water for 2 minutes) was cut to a length of 5 cm, and EOG was cut.
Sterilization treatment (50 ° C, 50%, 4 hours, 700mg
/ L). A Pseudomonas aeruginosa suspension having a concentration of about 1 × 10 ⁵ cells / ml was prepared using a broth solution (diluted 50-fold with physiological saline), and the catheter was immersed therein and shaken at 37 ° C. for 24 hours. Cultured. The antibacterial performance was evaluated by counting the number of bacteria in the liquid after the culture by a smear method. The results are shown in Table 1.

Example 2 5% as a coating liquid
Silicone adhesive (KE3479 manufactured by Shin-Etsu Chemical Co., Ltd.) A solution prepared by dispersing 20% sodium laurate with respect to the adhesive in a THF solution was prepared, immersed in a commercially available silicone urinary catheter for 1 minute, and then dried at 50 ° C. for 5 hours. Then, a coating layer containing sodium laurate was prepared. Then, it is immersed in an aqueous solution of silver acetate adjusted to 0.05% to 50%.
Shake at ℃ for 24 hours. Place this urinary catheter in running water 2
It was washed with water for 60 days and dried at 60 ° C. for 10 hours to obtain an antibacterial urinary catheter. The antibacterial evaluation was performed in the same manner as in Example 1. The results are shown in Table 1.

Example 3 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
1.2 parts of stearic acid was added to prepare a natural rubber latex solution. The pH of the natural rubber latex was 10.5.

Next, the immersion mold for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (80 ° C., 10 minutes) to obtain a catheter repeatedly until the thickness became 1.6 mm. The catheter removed from the mold was immersed in a natural rubber latex solution containing 0.1% disodium lauroyl-L-glutamate for 1 minute, dried at 80 ° C. for 10 minutes, and dried.
A coating layer containing disodium L-glutamate was provided. Then, after immersing in an aqueous solution of silver acetate adjusted to 0.05% and shaking at 50 ° C. for 12 hours, the urinary catheter was washed with running water for 2 days and dried at 60 ° C. for 12 hours.
An antimicrobial urinary catheter was obtained. The antibacterial evaluation was performed in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 1 0.3 part of zinc dimethyldithiocarbamate, 1.5 parts of colloidal sulfur, 3.0 parts of active zinc were added to 100 parts of natural rubber latex having a solid content of 60%.
1.2 parts of stearic acid was added to prepare a natural rubber latex solution. The pH of the natural rubber latex was 10.5.

Next, the immersion mold for urinary catheter was immersed in the above-mentioned natural rubber latex solution and dried (at 80 ° C. for 10 minutes) repeatedly to a thickness of 1.6 mm. The last is 70 ° C, 12
After drying for an hour, a urinary catheter was prepared. Then 0.05
%, And shaken at 50 ° C. for 12 hours. Wash the urinary catheter for 2 days in running water
After drying at 12 ° C. for 12 hours, an antibacterial urinary catheter was obtained. The antibacterial evaluation was performed in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 2 0.5 part of 2-mercaptobenzothiazole zinc salt, 1.5 parts of colloidal sulfur, 1.0 part of active zinc were added to 100 parts of anionic styrene-butadiene copolymer latex having a solid content of 50%. And 1.0 part of stearic acid were added to prepare a synthetic rubber latex solution. The pH of the synthetic rubber latex solution was 10.5. .

Next, the immersion mold for urinary catheter was repeatedly immersed in the above synthetic rubber latex solution and dried (80 ° C., 10 minutes) to a thickness of 1.6 mm, and finally dried at 70 ° C. for 12 hours. I got 5% of the above catheter
Was immersed in a taurine aqueous solution adjusted to 30 ° C. for 6 hours. Thereafter, the catheter was washed with running water for 2 minutes and further immersed in a 0.1% silver nitrate aqueous solution.
Shake for 2 hours. The urinary catheter was washed again with running water for 2 days and dried at 60 ° C. for 10 hours to obtain an antibacterial urinary catheter. The antibacterial evaluation was performed in the same manner as in Example 1.
The results are shown in Table 1.

Comparative Example 3 A commercially available urinary catheter made of silicon was immersed in an aqueous solution of silver nitrate adjusted to 0.05%.
Shake at 18 ° C. for 18 hours. After that, the catheter was placed in running water 3
After washing with water for 60 days and drying at 60 ° C. for 10 hours, an antibacterial catheter was obtained. The antibacterial evaluation was performed in the same manner as in Example 1.
The results are shown in Table 1.

[0067]

[Table 1]

[0068]

According to the antimicrobial urinary catheter of the present invention, the antimicrobial performance is maintained not only at the initial stage but also for a long period of time because the antimicrobial silver compound is present at a high concentration on the catheter surface.

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Claims (7)

[Claims] An antimicrobial urinary guide comprising: forming a coating layer containing a compound capable of binding to an antimicrobial agent on the surface of a urinary catheter; and introducing the silver compound to the surface with an aqueous solution of a water-soluble silver compound. Method for manufacturing a catheter. 2. The method for producing an antimicrobial urinary catheter according to claim 1, wherein the coating composition containing a compound capable of binding to the antimicrobial agent contains a silicone composition. 3. The antibacterial agent is at least one selected from silver nitrate, silver acetate, and silver perchlorate.
A method for producing the antibacterial urinary catheter according to the above. 4. The compound capable of binding to an antibacterial agent is an amino acid,
4. The method for producing an antimicrobial urinary catheter according to claim 1, wherein the catheter is at least one selected from an amino acid oligomer, an amino acid polymer and an amino acid derivative. 5. The method for producing an antimicrobial urinary catheter according to claim 1, wherein the compound capable of binding to the antimicrobial agent is an anionic surfactant. 6. The method for producing an antimicrobial urinary catheter according to claim 1, wherein the compound capable of binding to the antimicrobial agent is at least one selected from a compound having a carboxyl group and a compound having a sulfonic acid group. 7. An antibacterial urinary catheter obtained by the production method according to claim 1.