JP2000296175A - Powdery chemical dissolving device for dialysing fluid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a powdery chemical dissolving device for dialysing fluid that can dissolve a powdery chemical for dialysing fluid in a large amount in a short time. SOLUTION: This device includes a dissolving vessel 11 into which a powdery chemical P for a dialyzate and RO water W are introduced to dissolve the chemical in the RO water, a filter 2 provided within the dissolving vessel 11, and a liquid circulation line 3 provided outside the dissolving vessel 11 and having a liquid circulation pump 33 for causing a dissolving solution and/or RO water in the upper portion of the filter 2 to circulate the RO water into a cell 12 defined by the filter 2.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for dissolving a powdered drug for a dialysate for preparing a dialysate from a powdered drug for a dialysate and RO water, a dissolving method using the same, and further comprising the dissolving apparatus. And a dialysate preparation device.

[0002]

2. Description of the Related Art When performing hemodialysis on a patient with reduced renal function, the patient's blood is purified in an artificial kidney. Inside the artificial kidney, a dialysate is perfused and passes through a dialysis membrane. It is common practice to contact the patient's blood and transfer waste products in the blood to the dialysate side. As this dialysate, acetic acid dialysate has been widely used. In recent years, sodium bicarbonate (sodium bicarbonate) which dramatically reduces discomfort during dialysis
Have been replaced by those that use

A dialysis solution containing baking soda is usually one containing an electrolyte component (eg, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate) and a pH adjuster (eg, acetic acid) (hereinafter referred to as agent A), (Hereinafter referred to as “agent B”). These dialysis solutions may contain a sugar such as glucose, or may use a separate C-containing sugar.

Conventionally, the A agent and the B agent have been sold and used in the form of a concentrated solution adjusted to a predetermined concentration. However, since about 5 L of solution B is required per patient per dialysis, a large amount of concentrated solution is used when performing dialysis treatment on a large number of patients. Therefore, in order to reduce the burden on the person who adjusts the dialysate and to save space, B powdered B
Agents are increasingly used. Along with this, a powder A agent and a single agent for powder dialysis have been developed.

[0005] A conventional dissolving device for dissolving a powdered drug is as follows.
For example, it comprises a dissolving tank (a), a liquid circulation line (c), a means (d) for supplying a chemical and / or RO water, and a means (e) for discharging a solution. The liquid circulation line (c) is connected to the dissolution tank (a) at a suction port at the top of the dissolution tank and a discharge port at the bottom, and is connected to the dissolution tank and / or RO water in the dissolution tank by a pump in the line. To dissolve the drug. Usually, a means (d) for supplying RO water and a means (e) for discharging a solution are connected to the liquid circulation line (c), and the solution is discharged from the discharge port via the liquid circulation line. You. Therefore, the discharge port is provided at the bottom of the dissolving tank so that all of the dissolving solution can be discharged.

Conventionally, about 7 kg of powdered B agent per 100 L of RO water is put into a dissolution tank and dissolved to prepare a liquid B agent of about 7%. Liquid A
And RO water were mixed. But,
When dissolving the powdered A agent using a conventional dialysate adjusting device, about 30 kg of the powdered A agent is added to 100 L of RO water in the dissolution tank. The particle size of the powdered A agent is
Since it is larger and coarser than the powdered B agent, if it is put into the dissolving tank in a short time, a large amount of the powdered A agent will accumulate at the discharge port of the liquid circulation line. As a result, a large amount of the powdered A agent enters the liquid circulation line, the pumping ability is reduced, the dissolution time is prolonged, and the powdered A agent having a large particle diameter that has entered the pump causes the inside of the pump. There is a possibility that the parts may be scraped and foreign substances may be mixed in the dialysate.

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a dialysate powder drug dissolving apparatus capable of dissolving a large amount of a dialysate powder drug in a short time in view of the above circumstances. .

[0008]

Means for Solving the Problems The inventors of the present invention have conducted various studies to solve the above-mentioned problems. As a result, a filter is provided in the dissolving tank, and the powder charged in the dissolving tank is circulated on the filter. It has been found that clogging of the liquid circulation line can be prevented by making the solution more and finely pulverized by the dissolving solution and / or RO water to gradually accumulate at the bottom of the dissolving tank, and arrived at the present invention.

That is, the present invention relates to a dialysate powder drug and R
A dissolving tank (a) for introducing O water and dissolving the drug in RO water, a filter (b) provided in the dissolving tank, and a solution and / or RO water on the upper part of the filter are separated by the filter. A powder drug dissolving apparatus for a dialysate, comprising a liquid circulation line (c) provided outside the dissolving tank and having a liquid circulation pump for circulating to the formed compartment.

[0010] The present invention is also a dialysate preparation apparatus provided with a water supply source, a water supply line, the above-mentioned powder drug dissolving device for dialysate, a storage tank and a storage line.

Further, the present invention introduces a dialysate powder drug and RO water into the dialysate powder drug dissolving apparatus, and through a liquid circulation line, a solution and / or RO remaining on the filter in the dissolution tank. The water is led to the filter compartment in the dissolving tank, the dissolving solution and / or RO water is transferred to the upper part of the filter through the filter, and the dissolving solution and / or RO water remaining on the filter is removed through the liquid circulation line. To the filter room inside, then
A method for dissolving a powder drug for a dialysate, characterized by dissolving a powder drug for a dialysate by repeating the transfer of the solution and / or RO water to the upper part of the filter through a filter.

In the present invention, the dialysate powder agent is a solid agent containing one or more of sodium hydrogen carbonate, an electrolyte component, a pH adjuster, and glucose.
Alternatively, it may be divided into two or three agents. Examples of the electrolyte component include inorganic salts such as sodium chloride, potassium chloride, calcium chloride, and magnesium chloride, sodium acetate, sodium citrate, and the like.
Mixtures of more than one species are included. Examples of the pH adjuster include acetic acid, lactic acid, citric acid, succinic acid and the like.

[0013] RO water is reverse osmosis.
Means water, and the amount is, for example, 7 to
8 L, 9 to 10 L for about 0.7 kg of Agent B. The dialysate has, for example, the following composition (final concentration). Sodium ion 130-150 mEq / L Potassium ion 1.0-3.0 mEq / L Calcium ion 2.0-4.0 mEq / L Magnesium ion 0-2.0 mEq / L Chloride ion 100-125 mEq / L Acetate ion 0-12 mEq / L Glucose 0-2.0 g / L Bicarbonate ion 20-40 mEq / L For the introduction of the drug and the RO water, either the drug or the RO water is introduced first, and the other is introduced. May be introduced later,
Although the medicine and the RO water may be introduced at the same time, considering the load on the filter 2, it is preferable to introduce the RO water first and then introduce the medicine.

The filter 2 provided in the dissolution tank 1 is preferably made of a synthetic resin such as polyethylene, polypropylene, polyethylene terephthalate, and polyamide. The mesh size of the filter 2 is preferably 5 to 20 mesh (wire diameter φ 0.3 to 1.0 mm, opening 0.9 to 4.0 mm, opening ratio 50 to 75%). With the filter 2 of the present invention, the powder medicine for dialysate supplied from the upper portion of the dissolving tank 11 can be once stopped at the upper portion of the filter 2 and gradually moved to the compartment 12. If the mesh size is less than 5 mesh, the powder medicine for dialysate supplied from the upper part of the dissolving tank 11 passes without stopping, and a large amount of powder accumulates at the bottom part of the dissolving tank 11. On the other hand, if it exceeds 20 mesh, the dissolution tank 11
It becomes difficult for the powder medicine for dialysate supplied from the upper part to pass through the filter 2, and the dissolution time becomes longer.

An example of the apparatus for dissolving a powdered drug for a dialysate according to the present invention will be described with reference to the drawings. 1 to 4 are schematic system diagrams of a dialysate powder drug dissolving apparatus of the present invention, and FIG. 5 is a schematic diagram of a dialysate dialysing apparatus of the present invention. As shown in FIGS. 1 to 4, the apparatus 1 for dissolving a powdered drug for a dialysate is defined by a dissolving tank 11, a filter 2 provided in the dissolving tank 11, a suction port 31 provided above the filter 2, and the filter 2. The liquid circulation line 3 communicates with the discharge port 32 provided in the image chamber 12.

Normally, a means for discharging a solution is connected to the liquid circulation line 3, and the solution is discharged from the discharge port 32 through the liquid circulation line 3.
Is preferably provided at the bottom of the image chamber 12. The discharged solution is transferred to a storage tank through a storage line. In the liquid circulation line 3, the solution and / or RO water in the solution tank 11 is supplied to the suction port 31 on the upper part of the filter 2.
A circulating pump 33 that circulates the solution and / or RO water is provided so that the solution and / or the RO water is discharged from the discharge port 32 at the bottom of the image chamber 12.

As shown in FIG. 1, the dialysate powder drug P charged into the dissolving tank 11 filled with a predetermined amount of RO water W partially dissolves, but most of it is retained at the upper part of the filter 2. , Gradually passes through the filter 2 and moves into the image chamber 12 (FIG. 2). The solution and / or RO water in the dissolving tank 11 sucked from the suction port 31 is discharged from the discharge port 32.
By being more discharged, the powder medicine on the upper portion of the filter 2 that has moved is promoted to dissolve, and the dissolved liquid is returned to the upper portion of the filter 2 through the filter 2. Further, the solution and / or RO water remaining on the upper part of the filter 2 are guided to the compartment 12 in the dissolution tank 11 through the liquid circulation line 3, and then the solution and / or RO water are passed through the filter 2 and to the upper part of the filter 2. While repeating the transfer,
All the powder medicines on the upper part of the filter 2 move into the compartment 12 (FIG. 3), and all the powder medicines are dissolved (FIG. 4).

It is preferable that the filter 2 is fixed below an intermediate portion in the dissolving tank 11. Filter 2
Is fixed to the dissolving tank 11 by various engaging means. However, in consideration of washing of the dissolving tank 11, it is preferable that the filter 2 such as a screw or a hook can be easily removed.

The dialysis fluid powder / medicine dissolving apparatus 1 of the present invention comprises:
As shown in FIG. 5, by connecting to the water supply source 4 and the storage tank 5, it can be used as a dialysate adjusting device. The dialysate powder drug is introduced from the upper part of the dialysate powder drug dissolution apparatus 1 and R
O water is supplied from a water supply source 4 through a water supply line 41.
The solution dissolved by the liquid circulation line 3 is transferred to the storage tank 5 through the storage line 51. The lysis solution is
By further supplying RO water from the water supply source 4 in the liquid storage tank 5, the RO water can be diluted to a specified concentration. Further, it can be transferred to a dilution tank (not shown) and diluted there. Further, by providing two or more dialysate powder drug dissolving devices 1, two or more dialysate powder drugs can be simultaneously dissolved to prepare a dialysate.

[0020]

The apparatus for dissolving a powdered drug for dialysis fluid according to the present invention comprises:
By providing a filter in the dissolving tank, even if a large amount of powdered drug having a large particle diameter is charged in a short time, the powder charged in the dissolving tank does not immediately accumulate at the bottom of the dissolving tank. This eliminates the risk of powder entering the liquid circulation line from the discharge port, thereby preventing a reduction in the capacity of the circulation pump and prolonging the dissolution time. In addition, since the powder can be prevented from entering the circulation pump, foreign matter does not enter the dialysate.

[Brief description of the drawings]

FIG. 1 is a schematic system diagram showing an example of a powder drug dissolution apparatus for a dialysate according to the present invention.

FIG. 2 is a schematic system diagram showing one example of a powder drug dissolving device for a dialysate according to the present invention.

FIG. 3 is a schematic system diagram showing one example of a powder drug dissolving device for a dialysate of the present invention.

FIG. 4 is a schematic system diagram showing an example of the apparatus for dissolving a powdered drug for a dialysate according to the present invention.

FIG. 5 is a schematic diagram showing an example of a dialysate preparation device using the dialysate powder drug dissolution device of the present invention.

[Explanation of symbols]

 REFERENCE SIGNS LIST 1 powder drug dissolving device for dialysate 11 dissolution tank 12 compartment 2 filter 3 liquid circulation line 31 suction port 32 discharge port 33 circulation pump 4 water supply source 41 water supply line 5 storage tank 51 storage line

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C077 AA05 BB01 DD17 EE03 GG09 KK15 KK30 PP07 PP08 PP12 PP13

Claims (9)

[Claims] 1. A dissolving tank (a) for introducing a dialysate powder drug and RO water and dissolving the drug in the RO water, a filter (b) provided in the dissolving tank, and dissolution of an upper portion of the filter. A powder drug dissolving device for a dialysate, comprising a liquid circulation line (c) provided outside the dissolution tank, the device having a liquid circulation pump for circulating a liquid and / or RO water to an compartment defined by the filter. 2. The dialysis solution for a dialysis solution according to claim 1, wherein the dissolution tank (a) is provided with a means (d) for supplying a powder drug for the dialysis solution and / or RO water and a means (e) for discharging the lysis solution. Powder drug dissolution equipment. 3. The apparatus according to claim 1, wherein the filter (b) is a synthetic resin filter. 4. The filter (b) has an eye size of 5 to 20.
2. The powder drug dissolving apparatus for dialysis fluid according to claim 1, wherein the apparatus is a mesh (wire diameter: 0.3 to 1.0 mm, opening: 0.9 to 4.0 mm, opening ratio: 50 to 75%). 5. The apparatus for dissolving a powder drug for a dialysate according to claim 1, wherein the powder drug for a dialysate is a solid preparation containing an inorganic salt. 6. The apparatus for dissolving a powder drug for a dialysate according to claim 1, wherein the powder drug for a dialysate is a solid preparation containing bicarbonate. 7. A dialysate preparation device provided with a water supply source, a water supply line, the powder drug dissolution apparatus for dialysate according to claim 1, a storage tank and a storage line. 8. The dialysate preparation apparatus according to claim 7, wherein two or more dialysate powder drug dissolution apparatuses according to claim 1 are provided. 9. The dialysate powder drug dissolving apparatus according to claim 1, wherein the dialysate powder drug and RO water are introduced, and the dissolution liquid and / or RO remaining on the upper part of the filter in the dissolution tank are introduced through a liquid circulation line. The RO water is guided to the filter compartment in the dissolving tank, the dissolving solution and / or RO water is transferred to the upper part of the filter through the filter, and the dissolving liquid and / or RO water remaining on the upper part of the filter are dissolved through the liquid circulation line. A dialysate powder, wherein the solution and / or RO water is transferred through a filter to the upper part of the filter by repeating the process, leading to the filter compartment in the tank, and thereby dissolving the dialysate powder drug. Drug dissolution method.