JP2000271227A - Treating device for atopy - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a treating device without depending on therapeutic agent for a person having allergy at a nose. SOLUTION: A treating device 1 is put into nostrils and held to block the infiltration of allergen through a mucosa. The core of the treating device for atopy has a part entangled with a fibrous material and a water absorbing material. An ion adsorption material for adsorbing the allergen, a porous structured material, and the like, are arranged inside the fibrous material and the water absorbing material. In addition, to prevent the infiltration of the allergen from a nasal mucosa, or the like, a method herein applicable is to coat the fibrous material and the water absorbing material with a substance which has property of an effective molar osmotic pressure, for example, salt, sugar such as glucose and mannitol in the form of being dissolved in a solution, or the substance is attached onto the fibrous material and the water absorbing material part in the production stage.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[Industrial application] An atopic therapy device used for people with nasal allergy, allergic bronchitis, or atopic bronchial asthma, and intended to prevent allergens from entering the nasal mucosa and pharyngeal mucosa. About the vessel.

[0002]

2. Description of the Related Art Drugs are mainly used to treat the above diseases. Others have put on masks and glasses to prevent the symptoms from worsening.

[0003]

The mainstream treatment for allergic diseases caused by house dust and pollen is drug treatment. And, among the therapeutic agents, antihistamines suppress the appearance of symptoms by reducing the sensitivity of histamine. As a side effect, it has a hypnotic effect and should not be used for early pregnancy. In addition, anticholinergic drugs are bronchodilators by blocking the parasympathetic nerve, and are effective for patients who have a severe nasal discharge. As a side effect,
Dryness and tongue thickening seen in atopin appear somewhat. Also, steroids have anti-inflammatory effects and are the most effective drugs for people with the above diseases. As a side effect, it is easy to induce osteoporosis, diabetes and high blood pressure. People with allergic diseases develop allergic symptoms for a certain period of the year or all year, and it is difficult to completely cure them. In addition, when a patient with a nasal allergy is sleeping upward during sleep, the nose is liable to be clogged, and when awake, a water-based nasal worm is likely to appear. In particular, the nasal mucous membrane of the portion called the inferior turbinate swells, and the air permeability deteriorates. And due to those various symptoms, it is necessary to take medicine regularly and sleep seems not to remain. In addition, there are concerns about side effects of the therapeutic agent.

[0004]

[Means for Solving the Problems] In order to solve the above problems, I propose the following idea. It is based on the nasal mucous mucosa of people with nasal allergies, and is effective for allergic bronchitis and atopic bronchial asthma in terms of removing allergens. One way is to absorb allergens, which are water-soluble proteins of pollen and house dust, before entering the body through the mucous membranes of the nose and pharynx. Second, the molar concentration of the extracorporeal secretion outside the mucous membrane is reduced by sneezing or the like, and the allergen easily enters the body due to osmotic pressure. Therefore, the molar concentration of the extracorporeal secretion is set to N
By raising the concentration with aCl, glucose, or the like, the difference in the osmotic pressure between the internal secretion fluid and the external secretion fluid is reversed or the difference is reduced, thereby preventing the entry of the allergen. Thirdly, if you are sleeping upward when you sleep, your nose may become congested.Therefore, measures to secure the total nasal passages, mainly the lower turbinate and the middle turbinate, to a certain size, Make breathing easier. Furthermore,
A small amount or a small amount of a drug used for the treatment of nasal allergic diseases such as an anticholinergic drug, a histamine drug and a steroid drug may be adhered to the fibrous material (4) of the treatment device. Further, a small or a small amount of the therapeutic agent may be contained in the solution component of the third aspect.

[0005]

[Action] The method of use is to use this atopic therapy device (1)
Attach so that it can be inserted into two nose cues. In addition, the method differs somewhat depending on the shape of the treatment device. For Type I and IT, bend the middle and insert it into the nose. In addition, U type and UT type are inserted into the nose ku so as to sandwich the nasal septum as it is. T
The mold inserts two into each nostril and fits the near side into the recess near the nostril. Also, fibrous material (4)
Make sure that the part touches the lower turbinate. The main purpose is to wear it before going to bed. Furthermore, it can be used at home or at work. Further, in order to accelerate the effect of the atopic therapy device, if the device is wetted with water immediately before use, NaCl and glucose are easily dissolved, so that the effect is quickly exhibited. In addition, a liquid in a drip-type wetting container (8) is separately treated with an atopic treatment device (1).
There is also a form that is used hanging on the fibrous material (4). When using this treatment device outside, the part that can be used by the user without being ashamed by using a transparent or skin-colored material that does not discomfort with the skin color is used for the part that can be seen from the outside when worn. Is better.

[0006]

Example 1 First, when a person with nasal allergy, allergic bronchitis or atopic bronchial asthma receives an allergen from the mucous membrane or the like, microphages or helper T
Cells, B cells, etc. are involved in complex production of IgE antibodies. Then, the IgE reaches the mucous membrane of the pharynx, the mucous membrane of the nasal cavity and the eyes via the bloodstream, where it is attached to mast cells and IgE receptors on the surface of basophils. When the allergen re-enters the mucous membrane, the IgE antibody attached to the mast cell or basophil captures and reacts with one antigen. A so-called antigen-antibody reaction occurs. next,
This reaction stimulates the release of chemical mediators such as histamine stored in mast cells and basophils. This chemical mediator promotes secretion of nasal crows, eyes and pharyngeal mucosa, promotes permeability of capillaries, sneezes, nasal stuffiness, nasal congestion, itchy eyes,
It will cause various allergic symptoms such as tears. The IgE antibody was produced as an antibody to a nematode parasite in the intestine such as a roundworm. that is,
It became an annoying disease for people living in modern society. And I hope that the devices we propose to solve this problem will be accepted by people in modern society. I'm going to get into the main topic. An allergic reaction is a reaction that occurs when humans enter the body, so if there is something that prevents the allergen from entering the mucous membrane,
It alleviates allergic symptoms. Also important is the relationship between the osmotic pressure inside the mucous membrane and outside the body. In short, the osmotic pressure of the secretion fluid on the mucosal surface outside the body is reduced by the nose and tears rather than the inside of the mucosal cells, thereby promoting the invasion of the allergen into the body. In addition, it seems that allergens may be carried into the body by Langerhans cells. Langerhans cells are clustered in the mucous membrane. It was also confirmed in the United States that mucous cells are the main components of the nasal cavity and pharynx, and that Langerhans cells attach to antigens, pass through the skin, and transport cells that cause allergic reactions. Therefore, as a result of examining the above-mentioned contents, I came up with the idea shown below.

First, the amount of allergens that enter the nasal mucous membrane is reduced. Furthermore, the idea is to increase the concentration of extracorporeal secretion fluid in the mucosal region to be higher than the osmolarity in the body or to reduce the difference, thereby preventing the invasion of allergens into the body as much as possible. In short, when the aqueous solutions having different concentrations are separated by a membrane such as cellophane, the moisture enters the higher concentration. And allergens are water-soluble proteins. Further, even if Na or glucose is dissolved in water, it cannot easily enter the mucous membrane. And it is a therapeutic device for atopy utilizing this fact. Next, the actual treatment device for atopy (1) will be described. The present invention is a therapeutic device for nasal allergy, allergic bronchitis and atopic type bronchial asthma, and has a function of being inserted into a nose ku so as to be sandwiched between nasal septum and held. To explain the shape of the core of the therapeutic device for atopy (1), rough shapes include an I type, a U type, a pair of T types, an IT type, and a UT type. However, any other shape may be used as long as it can be attached to and held on the nose claw. And type I can be held by hanging on the nose by the user bending the middle part and inserting it into two nose cues, such as stainless steel, iron, carbon steel, aluminum or zinc with oxidized surface. It consists of a metal (2) that has an affinity for the skin. There is also an IT type as a bendable type. This shape is a shape in which two perpendicular rod-shaped objects are connected at a certain interval around the center of the I-shape. In addition, U type is U
It has a mold and is made of a polymer (3) having affinity for skin, such as carbons, silicone resin or silicone rubber, and a metal (2) having affinity for skin. In addition, the UT type in which the U type and the T type are combined has a core shape in which two rod-shaped objects are orthogonal to each other with an interval sandwiching the center of the U type. Also, the T type is one product in a pair. In short, since there are two nostrils, they are each installed separately in the nostril. The core material is made of a metal (2) having an affinity for the skin or a polymer (3) having an affinity for the skin. Further, there is a shape in which the I-type, U-type, T-type, IT-type, and UT-type are bent, and the elastic metal is entirely covered with a polymer (3) having affinity for skin. Furthermore, I made of metal (2) having affinity for skin
The shape where the intermediate part of the mold, U type, IT type and UT type is covered with the polymer (3) that has affinity with the skin, and in the case of the T type, the shape where only one side is covered with the polymer (3) that has affinity with the skin And the shape of the core of the therapeutic device for atopy (1).

Further, on both ends of the above-mentioned I-type, U-type, IT-type and UT-type, and one end of the T-type, a fibrous material having affinity with skin such as cotton or pulp material and having good hydrophilicity is provided. There is a portion covered with the material (4). Further, a substance (5) having properties of effective osmotic pressure, such as saccharides such as NaCl, glucose, oligosaccharides and polysaccharides, and mannitol is attached to the fibrous material (4). In addition, any other substance having an effective osmolarity may be used. Also,
The processing step in this case is to immerse the material at the stage of fibers only in an aqueous solution in which the substance (5) having the property of effective osmolarity is dissolved, or to cover the core by entanglement with the fibrous material (4). After the process in the state where it is in, perform the process of soaking in the aqueous solution,
There is a production method of drying in the next step, or spraying the aqueous solution in the form of a mist, followed by drying. Further, powdered substances such as hydroxyapatite, tricalcium phosphate, chitosan and zeolite, which will be described in detail later, are made of the above fibrous material (4).
It is not entangled with fibrous material because of the fineness. However, a method of attaching the solution with the aid of an aqueous solution containing saccharides is also conceivable. However, since these materials are for absorbing allergens, these ion-adsorbing substances (6) and porous structural substances (7) are used. It is preferable that the fiber-like material layer portion in which) is entangled does not particularly adhere much saccharides. However, the substance that adsorbs the allergen is entangled with the inner layer of the fibrous material (4) layer. In addition, the fibrous material (4) layer portion is a layer where the substance (5) having the property of effective osmolarity is not adhered, and the material having the property of effective osmolarity ( It is good to form a fibrous material (4) layer to which 5) is attached. Also, using a gel of water-soluble chitosan, microfibrous cellulose or agar as a different form, entangle the fibrous material (4) and powder of a substance that can absorb allergens such as hydroxyapatite, tricalcium phosphate, and zeolite. Good results can be obtained by using means to make it easier. Further, if the allergen-adsorbing substance is in the form of granules, the substance is easily entangled without such a step.

Next, powder of hydroxyapatite or tricalcium phosphate, granules of a sintered body, or chitosan is entangled with the fibrous material (4) which is slightly different from the previous one. These are ion-adsorbing substances (6) that adsorb proteins and the like mainly by ion adsorption. In addition, a substance that can be adsorbed in another form may be entangled. They are made of artificial porous structural material (7) that cuts small holes by electron beam or plasma, etc. The porous structure material (7), such as activated charcoal which is originally porous or charcoal granulated at 400 ° C. or more, or zeolite, has a hollow structure, and therefore can adsorb various substances such as proteins. In short, one or more of the ion-adsorbing substance (6) or the porous structural substance (7) is entangled with the fibrous material (4). Among them, zeolite can be adsorbed by limiting the size of the substance to be adsorbed. The effective pore size of the zeolite is determined by the size of the specific oxygen ring forming the framework structure, and since the crystals are homogeneous throughout, it can be completely sieved by the difference in molecular diameter. Also, the amount of adsorption increases in proportion to the size of the cavity volume. The oxygen ring of zeolite that I know is 4.5.6.88.10.1
Since there are two allergens, which are water-soluble proteins, we think that they may form clusters as well as single-molecule states, so that there are 4.5, 6, 8, 10, 12, or more oxygen atoms It's a good idea to use a ring of zeolite with several different oxygen rings on purpose. In addition, charcoal fired at 500 ° C. or more has an action of decomposing proteins and the like. This is the so-called catalytic action.

Next, description will be made with reference to the drawings. FIG. 1 shows a type I atopic therapy device (1). Length is about 34mm
To 100 mm. In addition, children and adults use a certain amount of length, and it seems that some people do not want to insert their nose deeply after use. Also, since this shape is used by bending the middle, it is actually 100mm and 50mm
Within. Further, the material of the core in this figure has a twisted shape using two metal wires. This is because the fibrous material (4) is apt to be entangled with the metal wire serving as the core. If the core portion where the fiber is to be entangled is made uneven with a file or the like, the entanglement becomes even easier. There is also a method in which a fibrous material (4) is sandwiched between the two core wires at both ends and the metal core wire is twisted, and then the fibrous material is further entangled to a certain thickness. FIG. 2 shows a form in which a polymer (3) having affinity for the skin is present at the center of the form of FIG. In this case, there are a form in which the polymer cannot be removed and a form in which the polymer can be removed as shown in the figure. The following figure 3
It is sectional drawing of the part covered with the fibrous material (4) of FIGS. The center is the core portion, the metal (2) portion having affinity for the skin, and the outside thereof is a layer of the fibrous material (4) portion. In addition, around the inner layer (9) of the fibrous material (4) layer, an ion-adsorbing substance (6) and a porous structural substance (7) are mainly entangled with the fibrous layer. Also,
Here, ion-adsorbing substance (6) and porous structural substance (7)
Are both intrinsic. On the outer side of the inner layer (9), there is provided an outer layer (10) in which a substance (5) having an effective osmotic pressure such as saccharides, NaCl or mannitol is attached to a fibrous material (4). It has a certain form. However, even if the contained substances are not clearly classified, there is a certain effect. NaC
If l is a substance mainly composed of the substance (5) having an effective osmolarity, the fibrous material (4) has a substance (5) having an effective osmolarity and an ion-adsorbing substance (6). It is not necessary to classify the porous structure material (7) into layers. Next, FIG. 4 shows a U-shaped therapeutic device in which the core material is made of a metal (2) having affinity for skin or a polymer (3) having affinity for skin. This figure will be described with reference to a figure using a polymer. The core material is made of a resilient material, and is deliberately bent more than the state in which the therapeutic device is used, so as to enhance the holding ability of the therapeutic device to the nose. Stainless steel is the best material for the core. As the polymer material, carbon, silicon resin, silicon rubber, silicon rubber containing stainless steel, or the like is preferable. The length A of the treatment device is preferably about 15 mm to 50 mm. It is about half the length of the I-type. Next, FIG. 5 shows a treatment device in which a jacket portion made of a polymer (3) compatible with the skin of the original U-shaped portion is removable. The material of the core is preferably a metal (2) having an affinity for the skin such as stainless steel or a polymer (3) having an affinity for the skin such as silicone resin, but covered with a fibrous material (4). The part other than the part which has the polymer which has affinity with the skin which can be removed easily (3)
Because it is covered with plastic, it does not matter if it is a plastic material that does not dissolve much. Also, the contaminants in the fibrous material (4) are omitted because they are described in the I-type.

Next, FIG. 6 shows a form of a core of a T-type treatment device. In the case of this T-type, if there are not two, it does not play a role.
In short, it is a form that can be worn separately on the two nostrils. The core material is made of a metal (2) having an affinity for the skin or a polymer (3) having an affinity for the skin. The length A of the treatment device is preferably about 15 mm to 50 mm. In FIG. 7, the side opposite to the side of the T-shaped fibrous material (4) is detachable by a screw structure or the like. In either case, a material having affinity for the skin may be used, but a material of the core on the side of the fibrous material (4) may be a plastic material in which components are not so much dissolved. Next, FIG. 8 shows a metal (2) having affinity for skin and a polymer (3) having affinity for skin in the form of an IT-type therapeutic device.
Consists of In the material shown in the figure, a metal (2) having affinity for skin is formed so that a polymer (3) having affinity for skin is formed so as to cover a shape extending one sideways.
It is a T-shaped shape. And, to make it easier to understand, the polymer is drawn as a transparent material.
Next, FIG. 9 shows a form of a UT-type treatment device, which is made of a metal (2) having affinity for skin and a polymer (3) having affinity for skin. In the case of this figure, the side opposite to the fibrous material (4) is drawn as a shape that can be easily removed. However, the shape does not have to be removable.

[0012]

Embodiment 2 In this embodiment, a fibrous material (4) of an I-type, U-type, T-type, IT-type or UT-type therapeutic device has a spring shape, a zigzag shape or a fractal shape. However, depending on the shape, the total nasal passage, mainly the lower and middle nasal turbinates, can be secured to a certain size. However, the therapeutic device for atopy (1) is characterized in that it has the above shape even when covered with the fibrous material (4). Further, in order to realize this shape, it is preferable to use a resilient metal such as stainless steel as the material of the core, and to obtain the above-mentioned shape by stamping near the last stage of the manufacturing process of this therapeutic device. . In short, a fibrous material (4) is entangled with a metal core wire such as stainless steel to form an ion-adsorbing substance (6) or a porous structural substance (7).
However, a manufacturing method in which the above-described shape is formed by a stamping process or the like after performing the manufacturing steps inherent therein is the best.
However, in the case of a corrugated shape or a shape that is not so complicated, a core shape may be formed from the beginning, and then the fibrous material (4) may be entangled. FIG. 10 is a perspective view of a T-shaped spring. FIG. 11 shows a shape close to an I-type fractal. FIG. 12 shows a U-shaped wavy shape. FIG. 13 shows a UT type zigzag shape. Further, the combination of the above shape and the shape of the core may be any shape as long as it has been listed so far. In addition, even if the shape is not described through the first and second embodiments, the first and second embodiments may have another shape as long as it is in accordance with the intent that I have described so far.
In addition, the method of joining the core and the fibrous material (4) in Example 1 and Example 2 does not have to be the method listed up to now, but in consideration of safety, use of a synthetic adhesive was avoided. Better. However, sodium polyacrylate and carboxymethyl CM
C and agar are water-absorbing polymers, and their gels also have viscosity, so the gels may be used as adhesives.
Also, any material that is highly safe for the human body may be used.
However, it is important to use it after judging whether it can be used for allergic people. Further, in both the first and second embodiments, the material covering the core has been described only in the form of the fibrous material (4). However, for example, the sponge-like or sponge-like material does not change the effect. Instead of the material (4), a water-absorbing material (11) such as sponge or sponge may be used. In this case, an ion-adsorbing substance (6) or a porous structural substance (7) is attached to the surface of the core, or a water-absorbing material (1
1) The portion may be divided into several layers, and the ion-adsorbing substance (6) or the porous structural substance (7) may be entangled between the layers. FIG. 14 is a cross-sectional view of the structure described above with reference to FIG. 14. Here, the water-absorbing material (11) is divided into three layers, and the layer in contact with the core has no such material. It is a form in which the above materials are entangled between the following. However, this is only one example, so it may be different. In this figure, there is an ion-adsorbing substance (6) between the upper layers and a porous structural substance (7) between the inner layers.

[0013]

Embodiment 3 In this embodiment, a substance having an effective osmolarity such as a saccharide such as NaCl or glucose or mannitol among the components contained in the therapeutic device for atopy (1) of Embodiments 1 and 2 (5 ) May or may not be previously attached to the fibrous material (4) or the water-absorbing material (11). Instead, a wetting container (8) containing an aqueous solution in which a saccharide such as NaCl or glucose or a substance (5) having an effective osmotic pressure such as mannitol is provided, and the therapeutic device (1) for atopy is provided. Immediately before use, the fibrous material (4) or the water-absorbing material (11) is wetted with an aqueous solution containing a substance (5) having an effective osmolarity,
The effect can be expected to some extent. Also, in order to make it easy to attach to the fibrous material (4) or the water-absorbing material (11), the shape of the drip-type wetting container (8) is good.
In addition, the concentration of the aqueous solution is an effective osmolarity solution higher than the concentration of the body fluid in the inner cell part of the nasal mucosa. Three examples of addition of important components in the aqueous solution component will be given. In the first case, NaCl is mainly added to glucose or water-soluble chitosan to obtain an effective osmolarity solution higher than the body fluid concentration of the inner cell portion of the nasal mucosa. As a second example, Aloe vera extract of NaCl and polysaccharide and microfibrous cellulose are further added to thicken. As a third example, a small or trace amount of a therapeutic drug used for allergic rhinitis, such as an anticholinergic drug, an antihistamine drug or a steroid drug, is further added to the above two examples. Furthermore, as an antioxidant in the aqueous solution containing them,
L-ascobic acid, vitamin E, sesamol and the like may be added. However, it is better to use it in consideration of compatibility with other additives. In addition, in Examples 1, 2, and 3, any substance that is not described in Examples 1 to 2 can be a different substance as long as it is a substance having the property of effective osmolarity and high in safety. . In addition, a substance (5) having the property of effective osmolarity,
The gist of the patent can be attained to some extent without using the atopic therapy device (1) and using only the substance that adsorbs the allergen. FIG. 15 shows an example of the shape of the container of this embodiment, and any other shape may be used as long as it conforms to the gist of the patent. FIG. 16 is an explanatory diagram of a usage pattern in a state where the T-type is mounted on the nose crow.

EFFECTS OF THE INVENTION As a method for treating nasal allergy, allergic bronchitis and atopic bronchial asthma, drugs have been mainly used. There is a certainty that this therapeutic device and the container for wetting with an aqueous solution can reduce the amount and realize a more comfortable home life. I think that it can be used for many people suffering from allergic respiratory diseases.

[Brief description of the drawings]

FIG. 1 is a perspective view of an I type according to a first embodiment.

FIG. 2 is a perspective view of an I-type according to the first embodiment.

FIG. 3 is an enlarged sectional view of an I-shaped fibrous material portion of the first embodiment.

FIG. 4 is a perspective view of a U-shape according to the first embodiment.

FIG. 5 is a perspective view of a U-shape according to the first embodiment.

FIG. 6 is a perspective view of a T-type according to the first embodiment.

FIG. 7 is a perspective view of a T-type according to the first embodiment.

FIG. 8 is a perspective view of an IT type according to the first embodiment.

FIG. 9 is a perspective view of a UT type according to the first embodiment.

FIG. 10 is a perspective view of a T-shaped spring according to the second embodiment.

FIG. 11 is a perspective view of an I-type fractal shape according to the second embodiment.

FIG. 12 is a perspective view of a U-shaped wavy shape according to the second embodiment.

FIG. 13 is a perspective view of a UT zigzag shape according to the second embodiment.

FIG. 14 is an enlarged cross-sectional view of a water-absorbing material part according to the second embodiment.

FIG. 15 is a wetting container containing an aqueous solution of Example 3.

FIG. 16 is an explanatory view of a use form of the therapeutic device for atopy.

[Explanation of symbols]

 REFERENCE SIGNS LIST 1 therapeutic device for atopy 2 metal having affinity for skin 3 polymer having affinity for skin 4 fibrous material 5 substance having effective osmolarity 6 ion-adsorbing substance 7 porous structure substance 8 aqueous solution for wetting Container 9 Inner layer 10 Outer layer 11 Water-absorbing material A Length of therapeutic device for atopy

Claims (3)

[Claims] An atopic therapy device (1) for nasal allergy, allergic bronchitis and atopic bronchial asthma,
It has a function that it can be inserted into the nasal ku with the septum in between. To explain the shape of the core of the therapeutic device for atopy (1), rough shapes include an I type, a U type, a pair of T types, and a combined type of the I type, the U type, and the T type. Type I is a product that the user can hold by hanging the nose by bending the middle part of the treatment device for atopy and inserting it into the nose claw, such as stainless steel, iron, carbon steel, or aluminum with oxidized surface. It is made of a metal (2) having affinity for human skin, such as zinc. The U-type is a U-shaped material from the product stage, and is a polymer (3) having affinity for skin, such as carbons, silico resin or silicone rubber, or a metal (2) having affinity for skin. Consists of The T-type also comprises a metal (2) having affinity for skin and a polymer (3) having affinity for skin. In addition, IT and U which are the combined type of I and U and T
The T type is also composed of a metal (2) having an affinity for the skin and a polymer (3) having an affinity for the skin. In addition, I-type, U-type, T-type, IT-type, and UT-type metals can be bent or have elasticity covered with a polymer (3) compatible with the skin. The shape of the core of the therapeutic device for atopy (1) covered with the polymer (3) having an affinity for is obtained. In addition, I type and U
On both ends of the mold, IT type and UT type and on one end side of the T type, there is a portion covered with a fibrous material (4) such as cotton or pulp material, which has affinity for the skin and is more hydrophilic. is there. A substance (5) having the property of effective osmotic pressure such as saccharides, salts and mannitol is applied to the fibrous material (4). Further, the fibrous material (4) is entangled with a powder or a sintered body such as hydroxyapatite or tricalcium phosphate, which is an ion-adsorbing substance (6) that adsorbs proteins and the like mainly by the action of ions. You. Or entangle another form of adsorbent. They are made of fibers with good affinity for the skin, such as carbon fibers, and particles of metal oxides, such as carbon particles and alumina.
Artificial porous structure material (7) for making small holes by electron beam or plasma, or porous structure material (7) such as activated carbon that is originally porous, charcoal particles fired at 400 ° C or more, and zeolite Has a hollow structure and adsorbs various substances such as proteins. In short, one or more of the ion-adsorbing substance (6) and the porous structural substance (7) are entangled with the fibrous material (4). Further, these atopic treatment devices (1) may be configured to be removable. In this case, the side that is not covered with the fibrous material and the side that is covered with the fibrous material are detachable by a screw structure or the like. In this case, the material of the core may be a metal (2) having an affinity for the skin or a polymer (3) having an affinity for the skin. Further, a therapeutic device for atopy in which a water-absorbing material (11) such as a sponge or a spongy body may be used instead of the fibrous material (4). 2. A portion covered with a fibrous material (4) in the form of a core of an atopic treatment device (1) has a spring shape, a zigzag shape, a wavy shape, a fractal shape, or the like. The shape of the nasal passages around the lower turbinate mainly keeps a constant space. However, the portion of the core covered with the fibrous material (4) is a fibrous material (4).
The treatment device for atopy according to claim 1, wherein the shape is maintained even when the device is covered with a water-absorbing material (11). 3. A wetting container (8) containing an aqueous solution containing a substance (5) having an effective osmolarity such as a saccharide, a salt or mannitol in a main component is provided. The solution concentration is an effective osmolarity solution that is higher than the body fluid concentration of the inner cell portion of the nasal mucosa. Further, when the wetting container (8) containing the aqueous solution is provided, the fibrous material (4) or the water-absorbing material (11) may be made of a substance (5) having an effective osmotic pressure. 3. The therapeutic device for atopy according to claim 1, wherein said device does not need to be attached.