JP2000256125A - Composition having discrete cubic structure, and its use as emulsified composition or dermatological composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition capable of holding highly stable discrete cubic structure without significantly depending on the ethylene oxide chain length of the surfactant to be used, and usable in an emulsified composition or dermatological composition. SOLUTION: This composition is obtained by including 10-60 wt.% of at least one kind of a polyoxyethylene alkyl- or alkenyl ether-based surfactant with an ethylene oxide addition number of moles of 8-100 and 10-22C hydrocarbon groups, 20-80 wt.% of water, and 1-50 wt.% of at least one kind of polyhydric alcohol; alternatively, by including 10-70 wt.% of the above-mentioned at least one kind of surfactant, 10-70 wt.% of water, 1-80 wt.% of at least one kind of polyhydric alcohol, and 1-50 wt.% of an oil. The other objective emulsified composition or dermatological composition is obtained by including >=10 wt.% of the above-described composition.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an emulsion composition and a skin composition which can maintain a highly stable discontinuous cubic structure without much depending on the ethylene oxide chain length of a surfactant used. It relates to a composition which can be used as a product. More specifically, a composition having a discontinuous cubic structure, comprising a polyoxyethylene alkyl or alkenyl ether surfactant and water and a polyhydric alcohol or further an oil, and an emulsified composition thereof and skin The present invention relates to the use in a composition for medical use.

[0002]

2. Description of the Related Art It is known that in an aqueous solution containing a polyoxyethylene alkyl ether-based surfactant, a region having a discontinuous cubic structure exists, and a composition in such a region has high stability. (Kunieda et al .; Prog. ColloidPolym. Sci. 110 171-174)
(1998)). In addition, the behavior when oil is added to a polyoxyethylene alkyl ether surfactant / water system has been reported (Kunieda et al .; J. Phys. Chem. B 102) .
(5) 831-838 (1998)).

[0003] However, in the polyoxyethylene alkyl ether surfactant / water system, the region exhibiting a discontinuous cubic structure becomes wider depending on the ethylene oxide chain length of the polyoxyethylene alkyl ether surfactant. As a result, the melting point of the system increases. Therefore, it was necessary to control the melting point in order to use the composition in an emulsion composition or a skin composition.

[0004]

Therefore, in the present invention, the surfactant used has a highly stable discontinuous cubic crystal structure without much dependence on the ethylene oxide chain length,
It was intended to obtain a composition which can be easily used for an emulsion composition and a skin composition.

[0005]

As a result of various studies to solve the above problems, it has been found that a specific polyoxyethylene alkyl or alkenyl ether surfactant and water and a polyhydric alcohol, or even an oil are contained in a specific weight. It has been found that the melting point can be controlled without depending on the ethylene oxide chain length of the polyoxyethylene alkyl or alkenyl ether-based surfactant used, and a discontinuous cubic structure can be maintained, and the present invention is completed. Reached.

That is, in the present invention, one or two or more polyoxyethylene alkyl or alkenyl ether surfactants having a hydrocarbon group of 8 to 100 carbon atoms and 10 to 22 carbon atoms are added with ethylene oxide. ,
One or more of water and a polyhydric alcohol are contained in an amount of 10 to 60% by weight, 20 to 80% by weight, and 1 to 50% by weight, respectively, to obtain a composition having a discontinuous cubic structure. Alternatively, one or more of the surfactants,
One or two or more of water, oil and polyhydric alcohol containing 10 to 70% by weight, 10 to 70% by weight, 1 to 80% by weight and 1 to 50% by weight, respectively, to form a discontinuous cubic crystal. A composition having a structure is obtained.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the polyoxyethylene alkyl or alkenyl ether surfactant used for solubilization or emulsification has an ethylene oxide addition mole number of 8 to 100, and has an alkyl group or alkenyl group. Those having 10 to 22 carbon atoms are used. For example,
Polyoxyethylene (8E.O.) lauryl ether, polyoxyethylene (10E.O.) lauryl ether, polyoxyethylene (21E.O.) lauryl ether, polyoxyethylene
(25E.O.) lauryl ether, polyoxyethylene (8E.O.)
O.) Cetyl ether, polyoxyethylene (10E.O.) cetyl ether, polyoxyethylene (15E.O.) cetyl ether, polyoxyethylene (20E.O.) cetyl ether, polyoxyethylene (25E.O. ) Cetyl ether, polyoxyethylene (30E.O.) Cetyl ether, polyoxyethylene (4
0E.O.) Cetyl ether, polyoxyethylene (10E.O.) stearyl ether, polyoxyethylene (20E.O.) stearyl ether, polyoxyethylene (12E.O.) oleyl ether, polyoxyethylene (15E.O.) O.) oleyl ether, polyoxyethylene (20E.O.) oleyl ether, polyoxyethylene (25E.O.) oleyl ether, polyoxyethylene (30E.O.) oleyl ether, polyoxyethylene (50E.O. ) Oleyl ether, polyoxyethylene (1
0E.O.) Behenyl ether, polyoxyethylene (20E.O.)
Examples include behenyl ether, polyoxyethylene (30E.O.) behenyl ether, and polyoxyethylene (30E.O.) hexyldecyl ether. One or more of these are selected and used.

In the present invention, a polyhydric alcohol having two or more hydroxyl groups in a molecule is contained as an essential component. Such polyhydric alcohols include diethylene glycol, triethylene glycol, polyethylene glycol, 1,2-propanediol, dipropylene glycol,
Diols such as 1,2-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,6-hexanediol, glycerin, diglycerin, glyceryl monopalmityl ether, glyceryl monostearyl ether, glyceryl mono Triols such as oleyl ether and derivatives thereof, monosaccharides such as glucose, disaccharides such as sucrose and maltose,
Examples thereof include sugar alcohols such as sorbitol and maltitol, and one or more kinds are selected from these and used.

In the present invention, a composition having a discontinuous cubic structure is obtained by mixing one or more polyoxyethylene alkyl or alkenyl ethers, one or more polyhydric alcohols and water. In this case, the amounts of the above components are 10 to 60% by weight, 1 to 50% by weight, and 20 to 80% by weight, respectively.

Further, in the present invention, a composition having a discontinuous cubic structure can be obtained by further adding oil. As the oil, those provided for skin external preparations can be preferably used, and liquid oils are particularly preferable for the purpose of improving transparency and the like.

For example, vegetable oils such as avocado oil, almond oil, olive oil, sesame oil, sasanqua oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil and the like. Animal oils such as turtle oil, mink oil, egg yolk oil, liquid waxes such as liquid lanolin and jojoba oil, n-decane, n-dodecane,
Alkanes such as n-tridecane, n-tetradecane, n-pentadecane, n-hexadecane, n-heptadecane and n-octadecane; hydrocarbons such as liquid paraffin, isoparaffin, squalane, and pristane; oleic acid, isopalmitic acid, isostearin Fatty acids such as acids, higher alcohols such as oleyl alcohol, 2-hexyldecanol, isopalmityl alcohol, isostearyl alcohol, and 2-octyldodecanol; isopropyl myristate, isopropyl palmitate, hexyl laurate;
Esters such as oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, and triglyceryl 2-ethylhexanoate are exemplified, and one or more of these are selected and used.

In the composition comprising the above polyoxyethylene alkyl or alkenyl ether surfactant, polyhydric alcohol, water and oil, the amounts of these components are respectively 10 to 70% by weight, 1 to 50% by weight, 10-70
% By weight and 1 to 80% by weight.

In the composition according to the present invention, the mixing ratio of the polyoxyethylene alkyl or alkenyl ether surfactant, the polyhydric alcohol and water, or even the oil is selected, so that the composition greatly depends on the ethylene oxide chain length. Without this, the melting point of the composition can be controlled widely. By incorporating the composition according to the present invention into an emulsified composition or a skin composition, these dosage forms can be controlled into various forms such as jelly, paste, and solid. In order to obtain a solid to semi-solid composition suitable for skin use, it is preferable to control the melting point to about 50 ° C to 80 ° C. The composition having a discontinuous cubic structure according to the present invention is contained in the emulsified composition or the skin composition in an amount of 10% by weight or more, preferably 20% by weight or more.

The composition for skin according to the present invention comprises a gel,
Provided as skin external preparations such as gels and creams, skin cosmetics such as moisturizing gels, cleansing gels, moisturizing gels, moisturizing creams, nutritional creams, packs, and makeup cosmetics such as creams and solids. be able to.

[0015] In addition to the above-mentioned composition having a discontinuous cubic structure, the emulsified composition and the skin composition according to the present invention may contain lower alcohols, oils and fats as long as the characteristics of the present invention are not impaired. , Amino acids, lactic acid, mucopolysaccharides, etc., humectants, thickeners, anti-inflammatory agents, vitamins, antioxidants, whitening agents, cell activators, antiperspirants, ultraviolet absorbers, antibacterial and antifungal agents ,
Flavors, animal tissue extracts, plant extracts, pigments, pigments, etc.
General additive components can be blended.

[0016]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

Examples 1 to 5 Polyoxyethylene (25E.O.) lauryl ether / water / 1,2-propanediol composition According to the composition shown in Table 1, it has a discontinuous cubic structure. A composition was prepared. The results of measuring the respective melting points are shown in Table 2 together with the melting point of Comparative Example 1 containing no polyhydric alcohol (weight ratio of polyoxyethylene (25EO) lauryl ether: water = 1: 1).

[0018]

[Table 1]

[0019]

[Table 2]

Examples 6 to 10 Polyoxyethylene (25E.O.) lauryl ether / water / 1,3-butanediol-based composition According to the composition shown in Table 3, the composition has a discontinuous cubic structure. A composition was prepared. The results of measuring the respective melting points are shown in Table 4 together with the melting points of Comparative Example 1 containing no polyhydric alcohol (weight ratio of polyoxyethylene (25EO) lauryl ether: water = 1: 1).

[0021]

[Table 3]

[0022]

[Table 4]

Examples 11 to 15 Polyoxyethylene (25E.O.) lauryl ether / water / glycerin composition A composition having a discontinuous cubic structure was prepared according to the composition shown in Table 5. . The results of measuring the respective melting points are shown in Table 6, together with the melting points of Comparative Example 1 containing no polyhydric alcohol (weight ratio of polyoxyethylene (25EO) lauryl ether: water = 1: 1).

[0024]

[Table 5]

[0025]

[Table 6]

[Examples 16 to 18] Polyoxyethylene (25E.O.) lauryl ether / water / sucrose composition A composition having a discontinuous cubic structure was prepared according to the composition shown in Table 7. did. The results of measuring the respective melting points are shown in Table 8 together with the melting point of Comparative Example 1 containing no polyhydric alcohol (weight ratio of polyoxyethylene (25EO) lauryl ether: water = 1: 1).

[0027]

[Table 7]

[0028]

[Table 8]

As apparent from Table 2, Table 4, Table 6, and Table 8, polyoxyethylene (25EO) lauryl ether.
In the water / polyhydric alcohol composition, a decrease in the melting point was observed as the polyhydric alcohol content increased. The decreasing rate of the melting point was remarkably observed in the dihydric alcohol. In addition, there was no significant difference in the reduction rate of the melting point of the trihydric or higher alcohols, and the reduction rate of the melting point was slower than that of the dihydric alcohol.

[Examples 19 to 22] Polyoxyethylene (25E.O.) lauryl ether / water / 1,3-butanediol / n-decane composition According to the composition shown in Table 9, a discontinuous cubic was obtained. A composition having a crystalline structure was prepared.

[0031]

[Table 9]

Examples 23 to 25 Polyoxyethylene (25E.O.) lauryl ether / water / glycerin /
n-Decan-based composition A composition having a discontinuous cubic structure was prepared according to the composition shown in Table 10.

[0033]

[Table 10]

For Examples 19 to 25, see Table 11
The melting points were measured together with Comparative Examples 2 to 5 shown in Table 2 and the results are shown in Table 12.

[0035]

[Table 11]

[0036]

[Table 12]

[Examples 26 to 30] Polyoxyethylene (25EO) lauryl ether / water / 1,3-butanediol / n-hexadecane composition According to the composition shown in Table 13, a discontinuous cubic was obtained. A composition having a crystalline structure was prepared.

[0038]

[Table 13]

Examples 31 to 35 Polyoxyethylene (25E.O.) lauryl ether / water / glycerin /
n-Hexadecane-based composition According to the composition shown in Table 14, a composition having a discontinuous cubic structure was prepared.

[0040]

[Table 14]

Examples 36 to 40 Polyoxyethylene (25E.O.) lauryl ether / water / 1,3-butanediol / squalane composition Discontinuous cubic structure according to the composition shown in Table 15 Was prepared.

[0042]

[Table 15]

Examples 41 to 45 Polyoxyethylene (25E.O.) lauryl ether / water / glycerin /
Squalane-Based Composition The composition shown in Table 16 was used to prepare a composition having a discontinuous cubic structure.

[0044]

[Table 16]

The melting points of Examples 26 to 45 and Comparative Examples 6 to 15 shown in Tables 17 and 18 were measured.
The results are shown in FIG.

[0046]

[Table 17]

[0047]

[Table 18]

[0048]

[Table 19]

As is clear from Tables 12 and 19, the melting point increases with an increase in the oil content in Comparative Examples, but the melting point decreases in Examples of the present invention containing polyhydric alcohols. The melting point was found to be controlled in a wide range of about 20 ° C to 70 ° C.

Example 46 Composition having a discontinuous cubic structure Polyoxyethylene (10EO) cetyl ether 25.0% by weight, water 70.0% by weight and 1,2-pentanediol
0% by weight was mixed and dissolved to make it uniform.

Example 47 Composition Having a Discontinuous Cubic Structure 50.0% by weight of polyoxyethylene (40EO) cetyl ether, 40.0% by weight of water and 10.0% by weight of diglycerin It was mixed and dissolved to make it uniform.

Example 48 Composition Having Discontinuous Cubic Structure Polyoxyethylene (25EO) Stearyl Ether
5 wt%, triglyceryl 2-ethylhexanoate 50.0 wt%, glycerin 15.0 wt% and purified water 17.5 wt% were mixed and heated to make uniform.

[Example 49] Composition having discontinuous cubic structure 20.0% by weight of polyoxyethylene (40EO) cetyl ether, 30.0% by weight of liquid paraffin, 1,2-pentanediol 10 0.0% by weight and purified water 40.0% by weight were mixed and heated to be uniform.

Example 50 Emulsion Composition Polyoxyethylene (20EO) Stearyl Ether
0% by weight, 41.5% by weight of water, 1,3-butanediol 2
0.0% by weight and 8.5% by weight of liquid paraffin are mixed,
Dissolve to homogeneity.

Example 51 Emulsion composition polyoxyethylene (50EO) oleyl ether 30.0
% By weight, 30.0% by weight of polyoxyethylene (10E.O.) behenyl ether, 32.5% by weight of water, 2.5% by weight of propylene glycol and 5.0% by weight of glycerin,
Dissolve to give a uniform composition. 85.0% by weight of this composition was dissolved by heating, 15.0% by weight of isopropyl palmitate was added, and the mixture was stirred and emulsified.

Example 52 Emulsion Composition 15.0% by weight of polyoxyethylene (2EO) cetyl ether, 20.0% by weight of polyoxyethylene (30EO) hexyldecyl ether, 25.0% water % By weight, glycerin 3
0.0% by weight, 5.0% by weight of squalane and 5.0% by weight of jojoba oil were mixed and dissolved to make uniform.

Example 53 Humectant (1) Example 1 25.0 (% by weight) (2) Sodium pyrrolidonecarboxylate 1.5 (3) Sodium hyaluronate 0.2 (4) Methyl paraoxybenzoate 0 1.1 (5) Purified water 73.2 Production method: (1) to (5) are mixed, heated to be dissolved and uniform, and then cooled.

Example 54 Skin Roughness Prevention Agent (1) Example 6 30.00 (% by weight) (2) Chamomile extract (50% by volume ethanol) 0.05 (3) Hamamelis extract (50% by volume ethanol) 0.05) (4) Riboflavin 0.20 (5) Methyl paraoxybenzoate 0.10 (6) Purified water 69.60 Production method: (1), (5) and (6) are mixed and heated. After dissolving
Add (2) to (4), mix and cool.

[Example 55] Anti-inflammatory agent (1) Example 11 35.0 (wt%) (2) Allantoin 0.1 (3) Dipotassium glycyrrhizinate 0.2 (4) Methyl paraoxybenzoate 0.1 ( 5) Purified water 64.6 Production method: After mixing (1), (4) and (5), heating and dissolving
Add (2) and (3), mix and cool.

Example 56 Antiphlogistic (1) Example 30 50.00 (% by weight) (2) Azulene 0.10 (3) Hydrocortisone acetate 0.25 (4) Purified water 49.65 Production method: (1) ) And (4) were mixed and heated to dissolve (2),
Add (3), mix and cool.

Example 57 Whitening Agent (1) Example 16 50.0 (% by weight) (2) Ascorbic Acid Phosphate 0.2 Magnesium Salt (3) Methyl Paraoxybenzoate 0.1 (4) Fragrance 0.1 (5) Purified water 49.6 Production method: After mixing (1), (3) and (5), heating and dissolving
Add (2), (4), mix and cool.

Example 58 Antiperspirant (1) Example 44 75.0 (% by weight) (2) Chlorohydroxyaluminum 10.0 (3) Ethanol 5.0 (4) Methyl parahydroxybenzoate 0.1 (5) Fragrance 0.1 (6) Purified water 9.8 Production method: (1), (2) and (6) are mixed, heated and dissolved, and then cooled. Next, (4) and (5) are dissolved in (3) and added and mixed.

Example 59 Anti-itch Agent (1) Example 45 50.0 (% by weight) (2) Diphenhydramine 1.0 (3) 1-Menthol 0.1 (4) dl-Camphor 0.1 ( 5) Methyl paraoxybenzoate 0.1 (6) Purified water 48.7 Production method: (1) is added to (6) and dissolved by heating.
To (5) are added sequentially to mix and homogenize.

Example 60 Sunscreen (1) Example 48 50.00 (% by weight) (2) 2-ethylhexyl paramethoxycinnamate 5.00 (3) Oxybenzone 3.00 (4) 4-tert- Butyl-4'-methoxydibenzoyl 1.00 Methane (5) Tocopherol acetate 0.05 (6) Methyl paraoxybenzoate 0.15 (7) Fragrance 0.10 (8) Purified water 37.70 (9) Titanium oxide 3.00 Production method: (1) is added to (8), heated and dissolved, and then (9)
Add and disperse. (2) to (7) are sequentially added thereto, mixed and homogenized, and then cooled.

Example 61 Packing Agent (1) Example 46 72.8 (% by weight) (2) Squalane 2.0 (3) Ethanol 5.0 (4) Methyl parahydroxybenzoate 0.1 (5) Fragrance 0.1 (6) Zinc oxide 10.0 (7) Kaolin 10.0 Manufacturing method: After heating and dissolving (1), add (2) and mix, then add (6) and (7) And disperse. In addition, (4), (5)
Dissolve and add to (3), mix and stir.

Example 62 Solid foundation (1) Example 49 45.0 (% by weight) (2) Vaseline 2.8 (3) Methyl parahydroxybenzoate 0.1 (4) Fragrance 0.1 (5) Talc 17.8 (6) Kaolin 15.0 (7) Titanium oxide 15.0 (8) Bengala 1.0 (9) Yellow iron oxide 3.0 (10) Black iron oxide 0.2 Production method: (1) Heated and melted, mixed and ground in advance (5) ~
Add (10) and disperse. (2) to (4) are sequentially added thereto, mixed and homogenized, and then cooled.

Example 63 Oil-based cleansing agent (1) Polyoxyethylene (10E.O.) cetyl ether 2.5 (% by weight) (2) Polyoxyethylene (30E.O.) hexyldecyl 12.5 ether (3) Liquid paraffin 55.0 (4) Squalane 10.0 (5) Triglyceryl 2-ethylhexanoate 5.0 (6) Glycerin 5.0 (7) Purified water 10.0 Production method: (1)- (5) is mixed and heated, and (6) is added to (7), and the heated mixture is added, mixed and homogenized.

With respect to the above Examples 53 to 63 of the present invention, the stability and the shape retention at -5 ° C. to 50 ° C. were evaluated. At that time, the following Comparative Examples 16 to 21 were also evaluated at the same time.

Comparative Example 16 Moisturizing Gel (1) Dipropylene glycol 7.0 (% by weight) (2) Polyethylene glycol 8.0 (average molecular weight 1,500) (3) Carboxyvinyl polymer 0.4 (4) Methylcellulose 0.2 (5) Polyoxyethylene (15E.O.) Oleyl 1.0 ether (6) Methyl paraoxybenzoate 0.1 (7) Fragrance 0.1 (8) Potassium hydroxide 0.1 (9) Purified water 83.1 Production method: (8) is dissolved in a part of (9) to prepare an aqueous solution.
After (3) and (4) are uniformly dissolved in the remainder of (9), (2) is added and dissolved to form an aqueous phase. On the other hand, (5) is added to (1) and dissolved by heating, and (6) and (7) are added. This is gradually added to the aqueous phase with stirring, and then the aqueous solution of (8) is added for neutralization.

Comparative Example 17 Moisturizing Gel Agent (1) Dipropylene glycol 10.0 (% by weight) (2) Carboxyvinyl polymer 0.5 (3) Potassium hydroxide 0.1 (4) Methyl paraoxybenzoate 0 .1 (5) Purified water 88.8 (6) Sodium pyrrolidonecarboxylate 0.5 Production method: (3) is dissolved in a part of (5) to prepare an aqueous solution.
After dissolving (2) in the rest of (5), dissolve (4) in (1) and add, then add aqueous solution of (3) to thicken, add (6) and mix .

Comparative Example 18 Oil-in-water cream (1) Stearyl alcohol 6.0 (% by weight) (2) Stearic acid 2.0 (3) Hydrogenated lanolin 4.0 (4) Squalane 9.0 (5) ) Octyl dodecanol 10.0 (6) Polyoxyethylene (25E.O.) cetyl ether 3.0 (7) Glyceryl monostearate 2.0 (8) 1,3-butylene glycol 6.0 (9) Glycerin 4.0 (10) Methyl paraoxybenzoate 0.1 (11) Fragrance 0.1 (12) Purified water 53.8 Production method: Mix (1) to (7), heat and dissolve at 70 ° C to oil Phase. On the other hand, (8) to (10) were added to (12) and dissolved,
Heat to The oil phase component is gradually added to the mixture while stirring, and emulsified, and homogenized by a homomixer. After cooling, (11) is added and mixed at 50 ° C.

[Comparative Example 19] Water-in-oil cream (1) Squalane 20.0 (wt%) (2) Cetyl isooctanoate 8.5 (3) Microcrystalline wax 1.0 (4) Organically modified bentonite 3 (5) Polyoxyethylene (20E.O.) glyceryl 0.2 Triisostearate (6) Glycerin 10.0 (7) Methyl parahydroxybenzoate 0.1 (8) Fragrance 0.1 (9) Purified water 58.8 Production method: (1) to (3) are mixed and dissolved by heating, and then (4) and (5) are added to 70 ° C. to uniformly disperse and dissolve to obtain an oily gel. On the other hand, (6) and (7) are dissolved in (9) and heated to 70 ° C. This aqueous phase is gradually added to the oily gel while stirring,
After homogenizing with a homomixer, the mixture is cooled, and (8) is added and mixed at 50 ° C.

Comparative Example 20 Cream Foundation (1) Stearic acid 5.00 (% by weight) (2) Glyceryl monostearate 2.50 (3) Cetostearyl alcohol 1.00 (4) Propylene glycol monolaurate 3.00 (5) Liquid paraffin 7.00 (6) Isopropyl myristate 5.00 (7) Sorbitol 3.00 (8) Triethanolamine 1.20 (9) Methyl paraoxybenzoate 0.15 (10) Purification Water 52.05 (11) Sericite 5.36 (12) Kaolin 4.00 (13) Titanium oxide 9.32 (14) Bengala 0.36 (15) Yellow iron oxide 0.80 (16) Black iron oxide 0 16 (17) Fragrance 0.10 Production method: (7) to (9) were added to (10) and dissolved, and (11) to (16) previously mixed and ground were added and dispersed. Heated to 75 ℃. On the other hand, (1) to (6) were mixed and dissolved by heating to 80 ° C. This oil phase component is added to the aqueous phase while stirring to emulsify, and after cooling, (17) is added and mixed at 50 ° C.

Comparative Example 21 Oily Compact Foundation (1) Solid Paraffin 3.0 (wt%) (2) Microcrystalline Wax 6.0 (3) Beeswax 2.0 (4) Vaseline 12.0 (5) Lanolin acetate 1.0 (6) Squalane 6.0 (7) Isopropyl palmitate 18.0 (8) Tocopherol acetate 0.2 (9) Talc 17.5 (10) Kaolin 15.0 (11) Titanium oxide 15. 0 (12) Bengala 1.0 (13) Yellow iron oxide 3.0 (14) Black iron oxide 0.2 (15) Fragrance 0.1 Production method: Mix (1) to (8) and melt at 85 ° C Then, (9) to (14), which have been mixed and pulverized in advance, are added thereto with stirring, and then ground and dispersed by a colloid mill. Then add (15),
After deaeration, pour into a container at 70 ° C and cool.

The stability and the shape retention were evaluated when the examples and comparative examples were stored at -5 ° C., 25 ° C., and 50 ° C. for one month, respectively. 1 in range
The test was performed twice a day under the condition where the temperature was changed for one week. The stability was evaluated based on whether or not a state change such as syneresis or precipitation and aggregation of the components was observed in each composition. "○: The state change was not observed at all", "△: The state There is a slight change. ",
"X: The state change is remarkably observed". The shape retention was evaluated by observing the change in viscosity or hardness of each composition, and the results were evaluated as follows: "○; no problematic change in viscosity or hardness was observed";"△: change in viscosity or hardness was observed. With a slight effect on shape retention. ",
"X: The change in viscosity or hardness is remarkable, and the effect on shape retention is remarkable". The results are summarized in Table 20.

[0076]

[Table 20]

As is clear from Table 20, all of Examples 53 to 63 of the present invention were stored at −5 ° C. to 50 ° C. and when stored at different temperatures within the above range. , Good stability and shape retention.
On the other hand, in Comparative Examples 16 to 21, particularly, -5
The evaluation of stability and shape retention during storage at ° C. and during storage with the temperature periodically changed was poor.

[0078]

As described above in detail, according to the present invention, the polyoxyethylene alkyl or alkenyl ether surfactant used has a highly stable discontinuous cubic structure independent of the ethylene oxide chain length. Thus, a composition suitable for use in an emulsified composition or a skin composition could be obtained.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/42 A61K 7/42 7/48 7/48 9/10 9/10 A61P 17/00 31/00 617 (72) Inventor Tomoaki Okamoto 112-1 Nogami, Okada-cho, Yokaichi, Shiga Prefecture Inside Noevir Products Research Laboratories (72) Inventor Yuko Hasegawa 112-1, Nogami, Okada-machi, Yokaichi, Shiga Prefecture Noevir Products, Ltd. F-term in the laboratory (reference) 4C076 AA09 BB31 DD09 DD38 EE51 FF43 FF68 4C083 AA122 AB051 AB212 AB232 AB242 AB332 AB432 AB442 AC012 AC022 AC032 AC072 AC111 AC112 AC122 AC181 AC182 AC212 AC342 AC352 AC422 AC472 AC482 AC552 AC612 AD612AD042 AD662 BB04 BB51 CC02 CC05 CC06 CC07 CC12 CC17 DD21 DD30 DD31 DD41 EE01 EE11 EE12 EE13 EE16 EE17

Claims (6)

[Claims] 1. An ethylene oxide addition mole number of 8 to 10.
0, one or more polyoxyethylene alkyl or alkenyl ether surfactants having a hydrocarbon group having 10 to 22 carbon atoms, and one of water and a polyhydric alcohol.
10 or 60% by weight, 20 or more
A composition having a discontinuous cubic structure, comprising 80% by weight and 1 to 50% by weight. 2. An ethylene oxide addition mole number of 8 to 10.
0, one or more of polyoxyethylene alkyl or alkenyl ether surfactants having a hydrocarbon group having 10 to 22 carbon atoms, and one or more of water, oil and polyhydric alcohol. , Respectively 10-70% by weight, 1
A composition having a discontinuous cubic structure comprising 0-70%, 1-80% and 1-50% by weight. 3. The method of claim 1, wherein the discontinuous cubic composition is
An emulsified composition comprising at least one weight percent. 4. The method according to claim 1, wherein the discontinuous cubic composition is
A composition for skin comprising at least% by weight. 5. The discontinuous cubic composition according to claim 2,
An emulsified composition comprising at least one weight percent. 6. The discontinuous cubic composition according to claim 2,
A composition for skin comprising at least% by weight.