JP2000236884A5 - - Google Patents
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- JP2000236884A5 JP2000236884A5 JP1999177846A JP17784699A JP2000236884A5 JP 2000236884 A5 JP2000236884 A5 JP 2000236884A5 JP 1999177846 A JP1999177846 A JP 1999177846A JP 17784699 A JP17784699 A JP 17784699A JP 2000236884 A5 JP2000236884 A5 JP 2000236884A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- peptide according
- interleukin
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- -1 Amino Chemical group 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 102000003810 Interleukin-18 Human genes 0.000 description 2
- 108090000171 Interleukin-18 Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 抗インターロイキン−１８抗体における可変領域のアミノ酸配列を含有し、インターロイキン−１８の生理作用を中和する性質を具備する人為的に創製されたペプチド。
【請求項２】 抗インターロイキン−１８抗体における可変領域のアミノ酸配列が、配列表における配列番号１及び／又は２に示すアミノ酸配列である請求項１に記載のペプチド。
【請求項３】 抗インターロイキン−１８抗体における可変領域のアミノ酸配列が、配列表における配列番号３、４、５、６、７及び／又は８に示すアミノ酸配列を含有する請求項１に記載のペプチド。
【請求項４】 配列表における配列番号９に示すアミノ酸配列を含有する請求項１に記載のペプチド。
【請求項５】 ヒト化された単一クローン抗体としての請求項１乃至４のいずれかに記載のペプチド。
【請求項６】 有効成分として請求項１乃至５のいずれかに記載のペプチドを含んでなる感受性疾患剤。
【請求項７】 抗自己免疫疾患剤、免疫抑制剤又は抗炎症剤としての請求項６に記載の感受性疾患剤。
【請求項８】 請求項１乃至６のいずれかに記載のペプチドを作用させることを特徴とするインターロイキン１８の中和方法。
[Claims]
1. An amino acid sequence of a variable region in an anti-interleukin-18 antibodyColumnAn artificially created peptide comprising the property of neutralizing the physiological action of interleukin-18.
Claims2An anti-interleukin-18 antibodyInVariable areaAmino acid sequence ofBut,SEQ ID NO: 1 in the sequence listing and/ OrAmino acid sequence shown in 2IsClaimIn oneThe peptide according to claim 1.
Claims3] The amino acid sequence of the variable region in the anti-interleukin-18 antibody isSEQ ID NO: 3 in Sequence Listing4, 5, 6, 7, and / orAmino acid sequence shown in 8ColumnClaims containingIn oneThe peptide according to claim 1.
Claims4] Sequence number in sequence listingTo 9The amino acid sequence shownIncludingClaims that haveIn oneThe peptide according to claim 1.
Claims5A humanized monoclonal antibody as claimed in any one of claims 1 to 10.Any of 4The peptide according to any one of the above.
Claims6An active ingredient as claimed in any one of claims 1 to 3.5A susceptible disease agent comprising the peptide according to any one of the above.
Claims7] Anti-autoimmune drug, Immunosuppressant or anti-inflammatoryClaims as6The susceptible disease agent according to the above.
Claims8Claims 1 through6A method for neutralizing interleukin 18, which comprises causing the peptide according to any one of the above to act.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11177846A JP2000236884A (en) | 1998-06-24 | 1999-06-24 | Peptide |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17758098 | 1998-06-24 | ||
| JP28904498 | 1998-10-12 | ||
| JP10-365023 | 1998-12-22 | ||
| JP36502398 | 1998-12-22 | ||
| JP10-177580 | 1998-12-22 | ||
| JP10-289044 | 1998-12-22 | ||
| JP11177846A JP2000236884A (en) | 1998-06-24 | 1999-06-24 | Peptide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000236884A JP2000236884A (en) | 2000-09-05 |
| JP2000236884A5 true JP2000236884A5 (en) | 2006-08-10 |
Family
ID=27474774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11177846A Withdrawn JP2000236884A (en) | 1998-06-24 | 1999-06-24 | Peptide |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2000236884A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2523912A1 (en) | 2003-04-30 | 2004-11-11 | Japan Science And Technology Agency | Human antihuman interleukin-18 antibody, fragment thereof and method of using the same |
| US20050100965A1 (en) * | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3122963B2 (en) * | 1995-02-10 | 2001-01-09 | 株式会社林原生物化学研究所 | Monoclonal antibody |
| JP2952750B2 (en) * | 1995-02-23 | 1999-09-27 | 株式会社林原生物化学研究所 | Monoclonal antibody |
-
1999
- 1999-06-24 JP JP11177846A patent/JP2000236884A/en not_active Withdrawn
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